CN102671180B - Medicine for treating rheumatic lumbago and preparation method thereof - Google Patents
Medicine for treating rheumatic lumbago and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a medicine for treating rheumatic lumbago and a preparation method thereof. The medicine is mainly prepared with ephedra, glycyrrhiza, doubleteeth pubescent angelica root, cinnamon, garden balsam stem and clematis root according to a certain weight ratio. The medicine has the functions of promoting blood circulation, relieving the rigidity of muscles, removing obstruction in meridians and collaterals and expelling wind-damp; when the medicine is used for treating rheumatic lumbago, the effect is rapid, and the cure rate is high.
Description
Technical field
The present invention relates to a kind of medicine for the treatment of lumbago due to pathogenic wind-dampness and preparation method thereof, belong to the field of Chinese medicines.
Background technology
Lumbago due to pathogenic wind-dampness disease is the common disease of contemporary people.Be due to waist, to suffer the invasion and attack of wind-cold damp pathogen, cause the resistance of blood vessels numbness, move not smooth, thereby cause the clinical symptoms such as waist swelling and pain, apathy.Western medical treatment is main mainly with antibiotics, but side effect can not be effected a radical cure more greatly.The traditional Chinese medical science is main mainly with massage, but massage also can only respite symptom, can not cure.So far, there is no the active drug for the treatment of lumbago due to pathogenic wind-dampness.
Summary of the invention
The inventor, according to the research of theory of Chinese medical science and clinical test and checking repeatedly, has finally found the Chinese medicine of effective treatment lumbago due to pathogenic wind-dampness, thereby has completed the present invention.
Object of the present invention is just to provide a kind of Chinese medicine composition that can effectively treat lumbago due to pathogenic wind-dampness.
Another object of the present invention has just been to provide the preparation method of this composition of medicine.
Medicine of the present invention selects Herba Ephedrae, Radix Glycyrrhizae, Radix Angelicae Pubescentis, Radix Saposhnikoviae, Cortex Cinnamomi, Fructus Trichosanthis, Radix Puerariae, Radix Paeoniae Alba, Radix Rehmanniae, Rhizoma Zingiberis Recens, Herba speranskiae tuberculatae, Radix Clematidis, the Cortex Eucommiae, Radix Aconiti Lateralis Preparata, the Rhizoma Atractylodis Macrocephalae, Radix Achyranthis Bidentatae, Herba Taxilli, Radix Polygalae Chinese medicine to combine, make each efficacy of drugs produce synergism these drug regimens, thus can fast treating lumbago due to pathogenic wind-dampness disease palindromia.Wherein select Herba Ephedrae to be because its nature and flavor are arduous, temperature, enters lung, urinary bladder channel, has diaphoresis, relievings asthma, the function of diuretic, the cold table that cures the wound is real, and fever with chills is lossless, headache is had a stuffy nose, arthralgia, cough and asthma, edema due to wind pathogen edema; dysuria, ailment said due to cold or exposure insensitive impediment, munbness, rubella pruritus.Select Radix Glycyrrhizae to be because its nature and flavor are sweet flat, enter spleen, stomach, lung meridian, have and middle emergency, lung moistening, removing toxic substances, the function of coordinating the actions of various ingredients in a prescription, process with controlling weakness of the spleen and stomach lack of appetite, stomachache loose stool, overstrain heating, consumptive lung disease cough, cardiopalmus, frightened carbuncle, raw with controlling laryngopharynx swelling and pain, peptic ulcer, ulcer sores, separates poison of drug and alimentary toxicosis.Select Radix Angelicae Pubescentis to be because its nature and flavor are arduous, temperature, enters kidney, urinary bladder channel, dispels the wind, and victory is wet, cold expelling, and the function of pain relieving, controls anemofrigid-damp arthralgia, waist urushic acid pain, trick spasm and pain, chronic tracheitis, headache, toothache.Selecting Radix Saposhnikoviae is that temperature, enters bladder, lung, spleen channel, delivers because of its property acrid-sweet flavor, dispels the wind, and victory is wet, and the function of pain relieving, controls affection of exogenous wind-cold, and headache is dizzy, stiffness of the nape, and anemofrigid-damp arthralgia, joint is ached, and extremity contraction is anxious, tetanus.Selecting Cortex Cinnamomi is because of its property acrid-sweet flavor, heat.Enter kidney, spleen, urinary bladder channel.Complement sun, warming the spleen and stomach, removing accumulated cold, promoting blood circulation.Control decline of the fire from the gate of life, cold extremities faint pulse, YANG-depletion collapse, stomachache is had loose bowels, colic of cold type renal mass, chills and pain of the waist and kness, amenorrhea and mass in the abdomen, carbuncle of yin nature, multiple abscess, and empty sun is more floating, heat in the upper and cold in the lower.Select Fructus Trichosanthis to be because its nature and flavor sweetness and bitterness is cold, have lung moistening, reduce phlegm, the function of eliminating stagnation, laxation, control phlegm-heat cough, the thoracic obstruction, blocked-up chest, consumptive lung disease hemoptysis, quenches one's thirst, jaundice.Select Radix Puerariae to be because its nature and flavor are sweet pungent, flat.Enter spleen, stomach warp.Yang invigorating expelling pathogenic factors from muscles, rash antidiarrheal, relieving restlessness is quenched the thirst.Cure the wound cold, warm headache stiffness of the nape, dysphoria with smothery sensation is quenched one's thirst, has loose bowels, dysentery, skin eruption is not saturating, hypertension, angina pectoris, deafness.Select Radix Paeoniae Alba to be because its nature and flavor picric acid is cool, enter liver, spleen channel, have nourishing blood to suppress the hyperactive liver, slow middle pain relieving, yin fluid astringing is received the function of antiperspirant, controls the breast abdomen pain over the hypochondriac region, dysentery stomachache, spontaneous sweating, fever due to yin deficiency, menoxenia, metrorrhagia, leukorrhagia.Select Radix Rehmanniae to be because its nature and flavor sweetness and bitterness is cool, enter the heart, liver, kidney channel, have YIN nourishing, the function nourishing blood, controls fever due to yin deficiency, quenches one's thirst, spit blood, and epistaxis, metrorrhagia, menoxenia, frequent fetal movement, the moon is hindered constipation.Select Rhizoma Zingiberis Recens to be because its nature and flavor are pungent, temperature, enters lung, stomach, spleen channel, deliver, and cold expelling, preventing or arresting vomiting, opens the function of expectorant, the wind and cold that cures cold, vomiting, phlegm retention, breathes with cough, and distension is had loose bowels, and separates the Rhizoma Pinelliae, Rhizoma Arisaematis and fish Eriocheir sinensis, birds and beasts meat poisoning.Selecting Herba speranskiae tuberculatae is that temperature, has wind-damp dispelling because of its nature and flavor sweetness and bitterness, invigorate blood circulation, and relaxing muscles and tendons, the function of pain relieving, dispelling the wind and dampness pathogens pain, sprain and contusion wound, innominate toxic swelling, eczema scrotum.Select Radix Clematidis to be because its nature and flavor are pungent salty, temperature, poisonous, enter urinary bladder channel, there is wind-damp dispelling, the meridian dredging, expectorant saliva, the function of the loose hypochondriac lump, controls gout, insensitive impediment, chills and pain of the waist and kness, beriberi, malaria ， lumps in the chest and abdomen, tetanus, tonsillitis, all a fishbone or other bone caught in the throat pharynxs.Select the Cortex Eucommiae to be because its nature and flavor are sweet micro-pungent, temperature, enters liver, kidney channel, has invigorating the liver and kidney, bone and muscle strengthening, and antiabortive function, controls spinal column ache, foot and knee flaccidity, dribbling urination, uncontrolled urination is itched, and vaginal bleeding during pregnancy is wanted to fall, hypertension.Selecting Radix Aconiti Lateralis Preparata is because of its property acrid-sweet flavor, and heat is poisonous, enter the heart, spleen, kidney channel, have recuperating depleted YANG to mend fire, the function of dispelling cold and removing dampness, control excessive YIN keeping YANG externally, loss of YANG due to profuse perspiration, vomiting and diarrhea is fainted contrary, trusted subordinate's cold type of pain, the splenic diarrhea cold-dysentery, beriberi edema, children's's intermittent infantile convulsion, the contracture of anemofrigid-damp arthralgia ， Wei lame, the disease of the leakage of carbuncle of yin nature skin ulcer and all chronic diseaseses.Selecting the Rhizoma Atractylodis Macrocephalae is because its property bitter but sweet flavor, and temperature, enters spleen, stomach warp, has spleen reinforcing, stomach reinforcing, dampness, and in function, control deficient QI of the spleen and stomach, anorexia, asthenia weak breath, deficiency-distension, has loose bowels, phlegm retention, edema, jaundice, arthralgia chiefly caused by damp pathogen, dysuria, dizziness, spontaneous perspiration, nausea is uneasy.Select Radix Achyranthis Bidentatae to be because its nature and flavor sweetness and bitterness acid is flat, enter liver, kidney channel, dissipating blood stasis blood is used in life, and the function of subduing inflammation, controls gonorrhea, hematuria, amenorrhea ， mass in the abdomen, difficult labour, retention of placenta, postnatal blood stasis stomachache, sore throat, carbuncle, traumatic injury, ripe in invigorating the liver and kidney, bone and muscle strengthening, controls waist kneecap pain, spasm of the limbs, flaccidity syndrome and arthralgia syndrome.Select Herba Taxilli to be because its property bitter but sweet flavor is flat, enter liver, kidney channel, have invigorating the liver and kidney, bone and muscle strengthening, except rheumatism, the meridian dredging, beneficial blood, antiabortive function, controls soreness of waist and knee joint, a little less than muscles and bones flaccidity, hemiplegia, beriberi, anemofrigid-damp arthralgia, vaginal bleeding during pregnancy metrorrhagia, lack of lactation after delivery.Selecting Radix Polygalae is that temperature, enters the heart, kidney channel, has the Fructus Alpiniae Oxyphyllae of calming the nerves, and eliminates the phlegm because of its nature and flavor toil, and the function of resolving depression, controls palpitation with fear, forgetful, nocturnal emission, and insomnia, cough ant phlegm, carbuncle skin ulcer is swollen.
The consumption of material medicine of the present invention is also that inventor draws through groping in a large number to sum up, and the consumption of each component all has good therapeutic effect within the scope of following weight:
6-10 grams of 6-10 grams of Radix Angelicae Pubescentiss of 8-12 grams of Radix Glycyrrhizaes of Herba Ephedrae
16-30 grams of 10-20 grams of Radix Puerariaes of 6-15 grams of Cortex Cinnamomis of Radix Saposhnikoviae
8-25 grams, 5-20 grams of Rhizoma Zingiberis Recenss of 5-25 grams of Radix Rehmanniaes of Radix Paeoniae Alba
8-22 grams of 8-15 grams of Cortexs Eucommiae of 15-30 grams of Radix Clematidis of Herba speranskiae tuberculatae
10-20 grams of 2-8 grams of Radix Achyranthis Bidentataes of 18-30 grams of Rhizoma Atractylodis Macrocephalaes of Radix Aconiti Lateralis Preparata
20-28 grams of 12-22 grams of Fructus Trichosanthiss of 25-40 grams of Radix Polygalaes of Herba Taxilli
Preferable amount is
8 grams of 8 grams of Radix Angelicae Pubescentiss of 9 grams of Radix Glycyrrhizaes of Herba Ephedrae
20 grams of 15 grams of Radix Puerariaes of 12 grams of Cortex Cinnamomis of Radix Saposhnikoviae
20 grams, 15 grams of Rhizoma Zingiberis Recenss of 20 grams of Radix Rehmanniaes of Radix Paeoniae Alba
20 grams of 12 grams of Cortexs Eucommiae of 25 grams of Radix Clematidis of Herba speranskiae tuberculatae
15 grams of 6 grams of Radix Achyranthis Bidentataes of 25 grams of Rhizoma Atractylodis Macrocephalaes of Radix Aconiti Lateralis Preparata
22 grams of 18 grams of Fructus Trichosanthiss of 30 grams of Radix Polygalaes of Herba Taxilli
The preparation method of medicine of the present invention is as follows
One, get the raw materials ready
1, Herba Ephedrae: choose decontamination, remove most woody stems and undesirable root, wash, cutting after micro-profit, is drying to obtain;
2, Radix Glycyrrhizae: choose decontamination, clean, be soaked in water and, pull out thoroughly time to eighty per cant, run through section, airing;
3, Radix Angelicae Pubescentis: choose decontamination, separately size, cleans, and runs through rear section, dry;
4, Radix Saposhnikoviae: remove residual stem, be soaked in water, pull out, run through section, dry;
5, Cortex Cinnamomi: choose clean impurity, scrape off rough bark, the used time smashes; Or scrape off rough bark, and by warm water, infiltrating a moment, section, dries;
6, Fructus Trichosanthis: remove handle, clean, put in steamer and steam to slightly soft, flatten, be cut into piece;
7, Radix Puerariae: choose decontamination, clean, be soaked in water, pull out, run through, section, dries in time;
8, Radix Paeoniae Alba: choose decontamination, size separately, is soaked in water to eighty per cant saturating, pulls out, and solarization is dried in the air, and profit is even to inside and outside humidity, and section is dry;
9, Radix Rehmanniae: water slightly steeps, cleans sediment contamination, pulls stewing profit out, and section is dried or dried;
10, Rhizoma Zingiberis Recens: choose decontamination, clean earth, used time section;
11, Herba speranskiae tuberculatae: choose decontamination, dry;
12, Radix Clematidis: choose clean impurity, remove residual stem, be soaked in water, pull out and run through, cutting, dries;
13, the Cortex Eucommiae: remove rough bark, clean, run through, dice or strand, dry;
14, gun additioner: get Radix Aconiti Lateralis Preparata and clean, clear water soaks a night, except peeling umbilicus, section, add again blister to mouth and taste slightly spicy sense for degree, take out, with ginger decoction, soak 1-3 days, then cook, roast to seventy percent dry again, pour urgent the stir-fry to cigarette of useing force in pot into and rise, micro-drum splits for degree, and taking-up cools;
15, the Rhizoma Atractylodis Macrocephalae: choose clean impurity, be soaked in water, pull out after bubble, run through, section, dries;
16, Radix Achyranthis Bidentatae: choose decontamination, clean, soften, go reed, cutting, dries;
17, Herba Taxilli: wash, run through, cutting, dries;
18, Radix Polygalae: choose decontamination, cutting, sieve dedust bits.
Two, preparation
1, the Herba Ephedrae of described weight, Radix Glycyrrhizae, Radix Angelicae Pubescentis, Radix Saposhnikoviae, Cortex Cinnamomi, Chinese juniper beach wormwood, Radix Puerariae, Radix Paeoniae Alba, Radix Rehmanniae, Rhizoma Zingiberis Recens, Herba speranskiae tuberculatae, Radix Clematidis, the Cortex Eucommiae, gun additioner, the Rhizoma Atractylodis Macrocephalae, Radix Achyranthis Bidentatae, Herba Taxilli, Radix Polygalae medicine are decocted with water, add for the first time 4 times of amounts of water, soak after 60 minutes, intense fire decocts boiling 10 minutes, with slow fire boiling, within 15 minutes, obtain decoction liquor for the first time again, decoction liquor is poured in container for the first time.
2, the medicinal residues after filtering are for the first time added to 2 times of amounts of water, first boil with high heat, then use slow fire boiling 20 minutes, decoction liquor is poured in container for the second time.
3, by twice decoction liquor mixing and stirring, then use slow fire boiling 20 minutes, be divided into 2 doses and take.
Medicine of the present invention has the invasion and attack of removing cold and wind damp, and the function that dredging blood vessel is not smooth, is used for the treatment of lumbago due to pathogenic wind-dampness, short treating period, instant effect, non-relapse after healing, has no side effect.
The specific embodiment
By test example, further set forth below the beneficial effect of medicine of the present invention, these test examples have comprised animal toxicity test report and the clinical observation material of medicine of the present invention.
The animal toxicity test report of [test example 1] medicine of the present invention:
Get 30 of rabbit, male and female dual-purpose, body weight 2.0-2.4kg, divides two groups, and 15 every group, wherein one group is overdose test group, and another group is normal amount test group.Super quantity group is 20ml/kg, and normal amount is 10ml/kg, and administering mode is administration by gavage administration, every day three times, serve on 7 days, observes administration reaction every day, and result shows that two groups of rabbit are movable, diet is normal, and medicine is without bad toxic and side effects.
The clinical observation material of [test example 2] Drug therapy lumbago due to pathogenic wind-dampness of the present invention
1, physical data
Accept out-patient's totally 178 examples for medical treatment, its mild or moderate class patient 120 examples, severe class patient 58 examples.
2, diagnostic criteria
Light-duty rheumatoid lumbago: waist swelling and pain, apathy.
Heavy rheumatoid lumbago: the waist active receiving restriction of bending forward and backward, flank pain, for a long time sitting; Fatiguability is weak, and whole body is listless and aching heavy, and affected part is afraid of cold.
3, Therapeutic Method
Select above-mentioned medicament, to patient, take, acute patient is each serving with 1 dose, and every day early, respectively take 1 evening, within 10 days, is a course for the treatment of, takes continuously 2 courses for the treatment of.Chronic patients is each serving with 1 dose, and every day, early, middle and late respectively clothes 1 time, 10 days was a course for the treatment of, took continuously 4 courses for the treatment of.
4, efficacy assessment standard
Effective: clinical symptom disappearance after treatment, it is normal that body constitution is recovered, and observes half a year without recidivist;
Take a turn for the better: clinical symptoms is obviously improved, and body constitution is progressively recovered;
Invalid: clinical partial symptoms disappears or without change, do not reach improvement standard person.
5, therapeutic outcome (seeing the following form)
In above-mentioned treatment, by Drug therapy lumbago due to pathogenic wind-dampness patient of the present invention 178 examples, acute patient's 120 examples wherein, effective 110 examples of result, obvious effective rate is 91.67%, 10 examples that take a turn for the better, improvement rate is 8.33%, total effective rate is 100%.Chronic patients 58 examples, effective 42 examples of result, obvious effective rate is 72.41%, 10 examples that take a turn for the better, improvement rate is 17.24%, invalid 6 examples, total effective rate is 89.66%.
Claims (3)
1. a medicine for the treatment of lumbago due to pathogenic wind-dampness, is characterized in that: it is to be made by the crude drug in following weight range:
6-10 grams of 6-10 grams of Radix Angelicae Pubescentiss of 8-12 grams of Radix Glycyrrhizaes of Herba Ephedrae
16-30 grams of 10-20 grams of Radix Puerariaes of 6-15 grams of Cortex Cinnamomis of Radix Saposhnikoviae
8-25 grams, 5-20 grams of Rhizoma Zingiberis Recenss of 5-25 grams of Radix Rehmanniaes of Radix Paeoniae Alba
8-22 grams of 8-15 grams of Cortexs Eucommiae of 15-30 grams of Radix Clematidis of Herba speranskiae tuberculatae
10-20 grams of 2-8 grams of Radix Achyranthis Bidentataes of 18-30 grams of Rhizoma Atractylodis Macrocephalaes of Radix Aconiti Lateralis Preparata
20-28 grams of 12-22 grams of Fructus Trichosanthiss of 25-40 grams of Radix Polygalaes of Herba Taxilli.
2. medicine according to claim 1, wherein the consumption of each crude drug is:
8 grams of 8 grams of Radix Angelicae Pubescentiss of 9 grams of Radix Glycyrrhizaes of Herba Ephedrae
20 grams of 15 grams of Radix Puerariaes of 12 grams of Cortex Cinnamomis of Radix Saposhnikoviae
20 grams, 15 grams of Rhizoma Zingiberis Recenss of 20 grams of Radix Rehmanniaes of Radix Paeoniae Alba
20 grams of 12 grams of Cortexs Eucommiae of 25 grams of Radix Clematidis of Herba speranskiae tuberculatae
15 grams of 6 grams of Radix Achyranthis Bidentataes of 25 grams of Rhizoma Atractylodis Macrocephalaes of Radix Aconiti Lateralis Preparata
22 grams of 18 grams of Fructus Trichosanthiss of 30 grams of Radix Polygalaes of Herba Taxilli.
3. the preparation method of medicine according to claim 1, is characterized in that: it comprises the following steps:
(1) get the raw materials ready
(1) Herba Ephedrae: choose decontamination, remove most woody stems and undesirable root, wash, cutting after micro-profit, is drying to obtain;
(2) Radix Glycyrrhizae: choose decontamination, clean, be soaked in water and, pull out thoroughly time to eighty per cant, run through section, airing;
(3) Radix Angelicae Pubescentis: choose decontamination, separately size, cleans, and runs through rear section, dry;
(4) Radix Saposhnikoviae: remove residual stem, be soaked in water, pull out, run through section, dry;
(5) Cortex Cinnamomi: choose clean impurity, scrape off rough bark, the used time smashes; Or scrape off rough bark, and by warm water, infiltrating a moment, section, dries;
(6) Fructus Trichosanthis: remove handle, clean, put in steamer and steam to slightly soft, flatten, be cut into piece;
(7) Radix Puerariae: choose decontamination, clean, be soaked in water, pull out, run through, section, dries in time;
(8) Radix Paeoniae Alba: choose decontamination, size separately, is soaked in water to eighty per cant saturating, pulls out, and solarization is dried in the air, and profit is even to inside and outside humidity, and section is dry;
(9) Radix Rehmanniae: water slightly steeps, cleans sediment contamination, pulls stewing profit out, and section is dried or dried;
(10) Rhizoma Zingiberis Recens: choose decontamination, clean earth, used time section;
(11) Herba speranskiae tuberculatae: choose decontamination, dry;
(12) Radix Clematidis: choose clean impurity, remove residual stem, be soaked in water, pull out and run through, cutting, dries;
(13) Cortex Eucommiae: remove rough bark, clean, run through, dice or strand, dry;
(14) gun additioner: get Radix Aconiti Lateralis Preparata and clean, clear water soaks a night, except peeling umbilicus, section, add again blister to mouth and taste slightly spicy sense for degree, take out, with ginger decoction, soak 1-3 days, then cook, roast to seventy percent dry again, pour urgent the stir-fry to cigarette of useing force in pot into and rise, micro-drum splits for degree, and taking-up cools;
(15) Rhizoma Atractylodis Macrocephalae: choose clean impurity, be soaked in water, pull out after bubble, run through, section, dries;
(16) Radix Achyranthis Bidentatae: choose decontamination, clean, soften, go reed, cutting, dries;
(17) Herba Taxilli: wash, run through, cutting, dries;
(18) Radix Polygalae: choose decontamination, cutting, sieve dedust bits;
(2) preparation
(1) Herba Ephedrae of described weight, Radix Glycyrrhizae, Radix Angelicae Pubescentis, Radix Saposhnikoviae, Cortex Cinnamomi, Chinese juniper beach wormwood, Radix Puerariae, Radix Paeoniae Alba, Radix Rehmanniae, Rhizoma Zingiberis Recens, Herba speranskiae tuberculatae, Radix Clematidis, the Cortex Eucommiae, gun additioner, the Rhizoma Atractylodis Macrocephalae, Radix Achyranthis Bidentatae, Herba Taxilli, Radix Polygalae medicine are decocted with water, add for the first time 4 times of amounts of water, soak after 60 minutes, intense fire decocts boiling 10 minutes, with slow fire boiling, within 15 minutes, obtain decoction liquor for the first time again, decoction liquor is poured in container for the first time;
(2) medicinal residues after filtering are for the first time added to 2 times of amounts of water, first boil with high heat, then use slow fire boiling 20 minutes, decoction liquor is poured in container for the second time;
(3) by twice decoction liquor mixing and stirring, then with slow fire boiling 20 minutes and get final product.
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