CN102772729B - Medicament for treating nasitis and preparation method thereof - Google Patents
Medicament for treating nasitis and preparation method thereof Download PDFInfo
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- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a medicament for treating nasitis and a preparation method thereof. The medicament is prepared from astragalus mongholicus, sharpleaf galangal fruit, schisandra chinensis, hemlock parsley, cochinchnese asparagus root, Chinese angelica, white peony root and the like in a certain weight proportion. The medicament has the functions of diminishing inflammation, promoting the restoration of consciousness, warming the medium and strengthening body resistance, and eliminating pathogen, and has the advantages of quick response, good curative effect and no relapse in treating nasitis.
Description
Technical field
The present invention relates to a kind of medicine for the treatment of rhinitis and preparation method thereof, belong to the field of Chinese medicines.
Background technology
Rhinitis is a kind of multiple commonly encountered diseases, all, because of viral infection, courses of infection or harmful gas stimulation etc., causes nasal mucosa or submucous tissue impaired, caused acute or chronic inflammatory disease.Rhinitis causes producing too much mucus, conventionally causes the symptoms such as watery nasal discharge, nasal obstruction.Rhinitis does not singly just affect nose, also can affect throat and eyes simultaneously.The multiplex antiinflammatory antibiotics of doctor trained in Western medicine symptomatic treatment, can not effect a radical cure, and side effect is larger, and therefore, people exist great demand to the Chinese medicine of effective treatment rhinitis.
Summary of the invention
The inventor, according to the research of theory of Chinese medical science and clinical test and checking repeatedly, has finally found the medicine of effective treatment rhinitis, thereby has completed the present invention.
Object of the present invention is just to provide a kind of composition of medicine that can treat rhinitis.
Another object of the present invention has just been to provide the preparation method of this composition of medicine.
Medicine of the present invention selects the Radix Astragali, Fructus Alpiniae Oxyphyllae, Fructus Schisandrae Chinensis, Folium Nelumbinis, Herba Asari, Semen Armeniacae Amarum, Fructus Xanthii, Radix Glycyrrhizae, the Rhizoma Atractylodis Macrocephalae, Gypsum Fibrosum, Rhizoma Chuanxiong, Radix Asparagi, Folium Mori, Radix Saposhnikoviae, Radix Platycodonis, Radix Angelicae Sinensis and the Radix Paeoniae Alba to combine, make each efficacy of drugs produce synergism these drug regimens, thus the effectively recurrence of fast treating rhinitis.Wherein select the Radix Astragali to be because its nature and flavor are sweet, tepor, enters lung, spleen channel, the useful consolidating superficial resistance of defending, and inducing diuresis to remove edema, poison holding, the function of granulation promoting, controls spontaneous perspiration, night sweat, arthralgia due to stagnation of blood, edema, carbuncle is not burst or is burst and hold back for a long time; Control internal injury overstrain, diarrhea due to hypofunction of the spleen, proctoptosis, deficiency of vital energy blood prostration, the disease of metrorrhagia and leukorrhagia and all weakness of QI blood deficiency.Select Fructus Alpiniae Oxyphyllae to be because its nature and flavor are pungent, temperature, enters spleen, kidney channel, has warming the spleen, warming the kidney, solid and gas, the function of arresting seminal emission, controls cold air stomachache, invasion by pathogenic cold is vomited and diarrhoea, many salivas, seminal emission, dribbling urination, night many urine.Select Fructus Schisandrae Chinensis to be because its nature and flavor are sour, temperature, enters lung, kidney channel, astringes the lung, and nourishing kidney, promotes the production of body fluid, and receives antiperspirant, and the function of arresting seminal emission, controls the deficiency of the lung and breath with cough, and xerostomia is done thirsty, spontaneous perspiration, night sweat, impairment caused by overstrain weakness and emaciation, emission, chronic diarrhea chronic dysentery.Select Folium Nelumbinis to be because its nature and flavor are pained, flat, enter the heart, liver, spleen channel, there is clearing away summer-heat and eliminating dampness, sending up the lucid YANG, the function of hemostasis, controls diarrhea due to summer heat and dampness, dizzy, aqueous vapor edema, thunder-headache, spits blood, epistaxis, metrorrhagia, has blood in stool, puerperal blood faints.Select Herba Asari to be because its nature and flavor are pungent, temperature, enters lung, kidney channel, dispel the wind, and cold expelling, row water, opens the function of stealing, and controls air-cooled headache, nasal sinusitis, pain relieving, phlegm retention cough with dyspnea, rheumatic arthralgia.Select Semen Armeniacae Amarum to be because its nature and flavor are bitter, temperature, poisonous, enter lung, large intestine channel, there is expelling phlegm for arresting cough, to relieving asthma, the function of intestine moistening, controls exogenous cough, dyspnea with fullness of the chest, sore throat, dryness of the intestine constipation.Select Fructus Xanthii to be because its nature and flavor are sweet, temperature, poisonous, enter lung, Liver Channel, there is loose wind, pain relieving, damp eliminating, the function of parasite killing, controls headche due to wind-cold, nasal sinusitis, toothache, anemofrigid-damp arthralgia, four foot spasm and pain, mange, pruritus.Select Radix Glycyrrhizae to be because its nature and flavor are sweet flat, enter spleen, stomach, lung meridian, have and middle emergency, lung moistening, removing toxic substances, the function of coordinating the actions of various ingredients in a prescription, process with controlling weakness of the spleen and stomach lack of appetite, stomachache loose stool, overstrain heating, consumptive lung disease cough, cardiopalmus, frightened carbuncle, raw with controlling laryngopharynx swelling and pain, peptic ulcer, ulcer sores, separates poison of drug and alimentary toxicosis.Selecting the Rhizoma Atractylodis Macrocephalae is because its property bitter but sweet flavor, and temperature, enters spleen, stomach warp, has spleen reinforcing, stomach reinforcing, dampness, and in function, control deficient QI of the spleen and stomach, anorexia, asthenia weak breath, deficiency-distension, has loose bowels, phlegm retention, edema, jaundice, arthralgia chiefly caused by damp pathogen, dysuria, dizziness, spontaneous perspiration, nausea is uneasy.Select Gypsum Fibrosum to be because its property acrid-sweet flavor is cold, enter lung, stomach warp, raw with there being expelling pathogenic factors from muscles for clearing heat, the function that relieving restlessness is quenched the thirst, controls calentura high fever and does not move back, vexed coma, delirium is gone mad, thirsty and dry pharynx, lung-heat dyspnea with rapid respiration, heatstroke spontaneous perspiration, stomach-fire headache, toothache, hyperactivity of toxic heat, send out speckle dermexanthesis, aphtha of the mouth and tongue, forges deposited promoting tissue regeneration and ulcer healing, external treatment ulcer sores, bursts and does not regain, the burning hot wound of soup.Select Rhizoma Chuanxiong to be because its nature and flavor are pungent, temperature, enters liver, gallbladder meridian, has activating QI to alleviate the depression, dispeiling pathogenic wind and removing dampness, the function of promoting blood circulation and stopping pain, control air-cooled headache revolve dizzy, hypochondriac pain abdomen pain, arthralgia due to cold clonic spasm of the muscle, amenorrhea, difficult labour, postpartum stagnation piece pain, ulcer sores.Select Radix Asparagi to be because its nature and flavor sweetness and bitterness is cold, enter lung, kidney channel, have YIN nourishing, moisturize, lung heat clearing, the function of pathogenic fire reducing, controls fever due to yin deficiency, and cough is spitted blood, consumptive lung disease, lung abscess, laryngopharynx swelling and pain, quenches one's thirst, constipation.Select Folium Mori to be because its property bitter but sweet flavor is cold, enter lung, Liver Channel, have expelling wind and clearing away heat, the function of cooling blood for improving eyesight, dispelling the wind and dampness pathogens heating, headache, conjunctival congestion, thirsty, cough due to lung-heat, migratory arthralgia, urticaria, lower limb elephatiasis.Selecting Radix Saposhnikoviae is that temperature, enters bladder, lung, spleen channel, delivers because of its property acrid-sweet flavor, dispels the wind, and victory is wet, and the function of pain relieving, controls affection of exogenous wind-cold, and headache is dizzy, stiffness of the nape, and anemofrigid-damp arthralgia, joint is ached, and extremity contraction is anxious, tetanus.Select Radix Platycodonis to be because its nature and flavor toil is flat, enter lung, stomach warp, have out lung qi dispersing gas, the function of the evacuation of pus of eliminating the phlegm, controls exogenous cough, laryngopharynx swelling and pain, lung abscess vomiting pus, fullness in the chest and hypochondriac pain, dysentery stomachache.Select Radix Angelicae Sinensis to be because its nature and flavor sweet, acrid, warm enters the heart, liver, spleen channel, have benefiting blood and regulating blood circulation, menstruction regulating and pain relieving, the function of moisturizing laxation, control menoxenia, amenorrhea stomachache ， mass in the abdomen knot is poly-, metrorrhagia, and headache due to deficiency of blood, dizzy, flaccidity syndrome and arthralgia syndrome, dryness of the intestine dyschezia, heavy after bloody dysentery, ulcer sores, injury from falling down.Select the Radix Paeoniae Alba to be because its nature and flavor picric acid is cool, enter liver, spleen channel, have nourishing blood to suppress the hyperactive liver, slow middle pain relieving, yin fluid astringing is received the function of antiperspirant, controls the breast abdomen pain over the hypochondriac region, dysentery stomachache, spontaneous sweating, fever due to yin deficiency, menoxenia, metrorrhagia, leukorrhagia.
The specific embodiment
The drug dose of the present invention's combination is also that inventor draws through groping in a large number to sum up, and the consumption of each component all has good therapeutic effect within the scope of following weight
Radix Astragali 10-23 gram of Fructus Alpiniae Oxyphyllae 8-20 gram of Fructus Schisandrae Chinensis 8-20 gram
Folium Nelumbinis 5-20 gram of Herba Asari 2-8 gram of Semen Armeniacae Amarum 2-12 gram
Fructus Xanthii 5-20 gram of Radix Glycyrrhizae 2-5 gram of Rhizoma Atractylodis Macrocephalae 20-36 gram
Gypsum Fibrosum 10-25 gram of Rhizoma Chuanxiong 12-23 gram of Radix Asparagi 5-15 gram
Folium Mori 5-15 gram of Radix Saposhnikoviae 2-10 gram of Radix Platycodonis 10-30 gram
Radix Angelicae Sinensis 10-25 gram of Radix Paeoniae Alba 8-20 gram
Wherein, be preferably
15 grams of 15 grams of Fructus Schisandrae Chinensis of 15 grams of Fructus Alpiniae Oxyphyllae of the Radix Astragali
6 grams, 5 grams of Semen Armeniacae Amarums of 12 grams of Herba Asaris of Folium Nelumbinis
30 grams of 3 grams of Rhizoma Atractylodis Macrocephalaes of 15 grams of Radix Glycyrrhizaes of Fructus Xanthii
9 grams of 15 grams of Radix Asparagi of 20 grams of Rhizoma Chuanxiongs of Gypsum Fibrosum
20 grams of 6 grams of Radix Platycodoniss of 9 grams of Radix Saposhnikoviaes of Folium Mori
10 grams of 15 grams of Radix Paeoniae Albas of Radix Angelicae Sinensis
The preparation method of medicine of the present invention is as follows
One, get the raw materials ready
1, the Radix Astragali: choose clean impurity, remove residual root head and hollow the greater, be soaked in water, pull out, run through rear timely section, dry;
2, Fructus Alpiniae Oxyphyllae: get Fructus Alpiniae Oxyphyllae and put in pot, fry to shell burned blackly, take out coldly, remove shell, get core and smash use to pieces;
3, Fructus Schisandrae Chinensis: sieve dedust bits, remove impurity, to put in food steamer and steam thoroughly, taking-up is dried;
4, Folium Nelumbinis: clean with water, cut off the base of a fruit and edge, shredding, dries;
5, Herba Asari: Ex-all impurity, water spray profit, cutting in time, dries;
6, Semen Armeniacae Amarum: choose clean impurity, put in boiling water and slightly boil, the Pi Wei that waits purses up and pulls out, soaks in cold water, sloughs kind of a skin, dries, winnows with a dustpan clean;
7, Fructus Xanthii: choose most impurity, deburring, sieve dedust bits, micro-stir-fry is to yellow, and taking-up cools;
8, Radix Glycyrrhizae: choose decontamination, clean, be soaked in water and, pull out thoroughly time to eighty per cant, run through section, airing;
9, the Rhizoma Atractylodis Macrocephalae: choose clean impurity, be soaked in water, pull out after bubble, run through, section, dries;
10, Gypsum Fibrosum: remove assorted stone, clean earth, be broken into fritter;
11, Rhizoma Chuanxiong: choose decontamination, separate large and small, be soaked in water, solarization is dried in the air, and cuts into slices after moistening, dry;
12, Radix Asparagi: choose decontamination, water is cleaned, and moistening is even to inside and outside humidity, cutting, dry;
13, Folium Mori: choose decontamination, rub with the hands brokenly, winnow with a dustpan destemming, sieve removes spare;
14, Radix Saposhnikoviae: remove residual stem, be soaked in water, pull out, run through section, dry;
15, Radix Platycodonis: choose clean impurity, except removing LU, clean and pull out, run through rear section, dry;
16, Radix Angelicae Sinensis: choose decontamination, clean, moistening, slightly dries in the air when suitable to inside and outside humidity, and section is dried;
17, the Radix Paeoniae Alba: choose decontamination, size separately, is soaked in water to eighty per cant saturating, pulls out, and solarization is dried in the air, and profit is even to inside and outside humidity, and section is dry.
Two, preparation
1, the Radix Astragali of described weight, Fructus Alpiniae Oxyphyllae, Fructus Schisandrae Chinensis, Folium Nelumbinis, Herba Asari, Semen Armeniacae Amarum, Fructus Xanthii, Radix Glycyrrhizae, the Rhizoma Atractylodis Macrocephalae, Gypsum Fibrosum, Rhizoma Chuanxiong, Radix Asparagi, Folium Mori, Radix Saposhnikoviae, Radix Platycodonis, Radix Angelicae Sinensis, Radix Paeoniae Alba crude drug are put into the container of boiling medicine and added 6 times of amounts of water, little fire decocted after 40 minutes, decoct with high heat boiling, use again slow fire boiling 20 minutes, obtain decoction liquor for the first time.
2, will filter for the first time rear medicinal residues and add 2 times of amounts of water, and decoct boiling, then within 15 minutes, obtain decoction liquor for the second time with slow fire boiling.
3, twice decoction liquor mixed, after be divided into 2 doses.
Medicine of the present invention has antiinflammatory, sensible, warming middle-JIAO righting, eliminating evil function.Treatment rhinitis instant effect, good effect, do not recur.
By test example, further set forth below the beneficial effect of medicine of the present invention, these tests comprise animal toxicity test and the clinical observation test of medicine of the present invention.
The animal toxicity test report of [test example 1] medicine of the present invention:
Get 30 of rabbit, male and female dual-purpose, body weight 2.0-2.5kg, divides two groups, and 15 every group, wherein one group is overdose test group, and another group is normal amount test group.Super quantity group is 25ml/kg, and normal amount is 10ml/kg, and administering mode is administration by gavage administration, every day twice, serve on 7 days, observes administration reaction every day, and result shows that two groups of rabbit are movable, diet is normal, and medicine is without bad toxic and side effects.
The clinical observation material of [test example 2] medicine of the present invention:
1, physical data:
Accept out-patient's 150 examples for medical treatment.
2, diagnostic criteria:
Nose stream clear water sample tears, have the symptoms such as nasal obstruction, rhinocnesmus.Can be with eye symptoms such as ophthalmic pruritus, conjunctival congestions.The common nasal mucosa of sign is pale, edema, nasal cavity watery secretion.
3, Therapeutic Method
Select above-mentioned medicament, every dose minute 2 times clothes, 15 days are a course for the treatment of, take continuously two courses for the treatment of.
4, efficacy assessment standard
Effective: clinical symptom disappearance after treatment, it is normal that body constitution is recovered, and observes half a year without recidivist;
Take a turn for the better: clinical symptoms is obviously improved, and symptom is progressively recovered;
Invalid: clinical partial symptoms disappears slowly or without change, do not reach improvement standard person.
5, therapeutic outcome
In above-mentioned treatment, by Drug therapy Allergic Rhinitis 150 examples of the present invention, effective 145 examples of result, obvious effective rate is 96.67%, 3 examples that take a turn for the better, and improvement rate is 2%, invalid 2 examples, total effective rate is 98.67%.
Claims (3)
1. a medicine for the treatment of rhinitis, is characterized in that: it is to be made by the crude drug within the scope of following weight:
Radix Astragali 10-23 gram of Fructus Alpiniae Oxyphyllae 8-20 gram of Fructus Schisandrae Chinensis 8-20 gram
Folium Nelumbinis 5-20 gram of Herba Asari 2-8 gram of Semen Armeniacae Amarum 2-12 gram
Fructus Xanthii 5-20 gram of Radix Glycyrrhizae 2-5 gram of Rhizoma Atractylodis Macrocephalae 20-36 gram
Gypsum Fibrosum 10-25 gram of Rhizoma Chuanxiong 12-23 gram of Radix Asparagi 5-15 gram
Folium Mori 5-15 gram of Radix Saposhnikoviae 2-10 gram of Radix Platycodonis 10-30 gram
Radix Angelicae Sinensis 10-25 gram of Radix Paeoniae Alba 8-20 gram.
2. medicine according to claim 1, wherein the consumption of each crude drug is:
15 grams of 15 grams of Fructus Schisandrae Chinensis of 15 grams of Fructus Alpiniae Oxyphyllae of the Radix Astragali
6 grams, 5 grams of Semen Armeniacae Amarums of 12 grams of Herba Asaris of Folium Nelumbinis
30 grams of 3 grams of Rhizoma Atractylodis Macrocephalaes of 15 grams of Radix Glycyrrhizaes of Fructus Xanthii
9 grams of 15 grams of Radix Asparagi of 20 grams of Rhizoma Chuanxiongs of Gypsum Fibrosum
20 grams of 6 grams of Radix Platycodoniss of 9 grams of Radix Saposhnikoviaes of Folium Mori
10 grams of 15 grams of Radix Paeoniae Albas of Radix Angelicae Sinensis.
3. according to the preparation method of medicine described in claim 1 or 2, it is characterized in that: it comprises the following steps:
(1) get the raw materials ready
(1) Radix Astragali: choose clean impurity, remove residual root head and hollow the greater, be soaked in water, pull out, run through rear timely section, dry;
(2) Fructus Alpiniae Oxyphyllae: get Fructus Alpiniae Oxyphyllae and put in pot, fry to shell burned blackly, take out coldly, remove shell, get core and smash use to pieces;
(3) Fructus Schisandrae Chinensis: sieve dedust bits, remove impurity, to put in food steamer and steam thoroughly, taking-up is dried;
(4) Folium Nelumbinis: clean with water, cut off the base of a fruit and edge, shredding, dries;
(5) Herba Asari: Ex-all impurity, water spray profit, cutting in time, dries;
(6) Semen Armeniacae Amarum: choose clean impurity, put in boiling water and slightly boil, the Pi Wei that waits purses up and pulls out, soaks in cold water, sloughs kind of a skin, dries, winnows with a dustpan clean;
(7) Fructus Xanthii: choose most impurity, deburring, sieve dedust bits, micro-stir-fry is to yellow, and taking-up cools;
(8) Radix Glycyrrhizae: choose decontamination, clean, be soaked in water and, pull out thoroughly time to eighty per cant, run through section, airing;
(9) Rhizoma Atractylodis Macrocephalae: choose clean impurity, be soaked in water, pull out after bubble, run through, section, dries;
(10) Gypsum Fibrosum: remove assorted stone, clean earth, be broken into fritter;
(11) Rhizoma Chuanxiong: choose decontamination, separate large and small, be soaked in water, solarization is dried in the air, and cuts into slices after moistening, dry;
(12) Radix Asparagi: choose decontamination, water is cleaned, and moistening is even to inside and outside humidity, cutting, dry;
(13) Folium Mori: choose decontamination, rub with the hands brokenly, winnow with a dustpan destemming, sieve removes spare;
(14) Radix Saposhnikoviae: remove residual stem, be soaked in water, pull out, run through section, dry;
(15) Radix Platycodonis: choose clean impurity, except removing LU, clean and pull out, run through rear section, dry;
(16) Radix Angelicae Sinensis: choose decontamination, clean, moistening, slightly dries in the air when suitable to inside and outside humidity, and section is dried;
(17) Radix Paeoniae Alba: choose decontamination, size separately, is soaked in water to eighty per cant saturating, pulls out, and solarization is dried in the air, and profit is even to inside and outside humidity, and section is dry;
(2) preparation
(1) Radix Astragali of described weight, Fructus Alpiniae Oxyphyllae, Fructus Schisandrae Chinensis, Folium Nelumbinis, Herba Asari, Semen Armeniacae Amarum, Fructus Xanthii, Radix Glycyrrhizae, the Rhizoma Atractylodis Macrocephalae, Gypsum Fibrosum, Rhizoma Chuanxiong, Radix Asparagi, Folium Mori, Radix Saposhnikoviae, Radix Platycodonis, Radix Angelicae Sinensis, Radix Paeoniae Alba crude drug are put into the container of boiling medicine and added 6 times of amounts of water, little fire decocted after 40 minutes, decoct with high heat boiling, use again slow fire boiling 20 minutes, obtain decoction liquor for the first time;
(2) will filter for the first time rear medicinal residues and add 2 times of amounts of water, and decoct boiling, then within 15 minutes, obtain decoction liquor for the second time with slow fire boiling;
(3) twice decoction liquor mixed, after be divided into 2 doses.
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| CN201210297174.XA CN102772729B (en) | 2012-08-21 | 2012-08-21 | Medicament for treating nasitis and preparation method thereof |
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| CN201210297174.XA CN102772729B (en) | 2012-08-21 | 2012-08-21 | Medicament for treating nasitis and preparation method thereof |
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101537089A (en) * | 2008-03-21 | 2009-09-23 | 北京中泰天和科技有限公司 | Pharmaceutical composition for curing allergic rhinitis and preparation method thereof |
| CN102579871A (en) * | 2012-02-20 | 2012-07-18 | 徐健 | Traditional Chinese medical composition for treatment of chronic rhinitis and preparation method thereof |
-
2012
- 2012-08-21 CN CN201210297174.XA patent/CN102772729B/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101537089A (en) * | 2008-03-21 | 2009-09-23 | 北京中泰天和科技有限公司 | Pharmaceutical composition for curing allergic rhinitis and preparation method thereof |
| CN102579871A (en) * | 2012-02-20 | 2012-07-18 | 徐健 | Traditional Chinese medical composition for treatment of chronic rhinitis and preparation method thereof |
Non-Patent Citations (4)
| Title |
|---|
| 中医对过敏性鼻炎研究进展;胡长庚等;<<辽宁中医药大学学报>>;20120630;第14卷(第6期);238-240 * |
| 张光新等.桂枝汤加减治疗过敏性鼻炎验案3则.<<江苏中医药>>.2011,第43卷(第6期),54-55. |
| 桂枝汤加减治疗过敏性鼻炎验案3则;张光新等;<<江苏中医药>>;20110630;第43卷(第6期);54-55 * |
| 胡长庚等.中医对过敏性鼻炎研究进展.<<辽宁中医药大学学报>>.2012,第14卷(第6期),238-240. |
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