CN103599246B

CN103599246B - Medicine of a kind of Cure for insomnia and preparation method thereof

Info

Publication number: CN103599246B
Application number: CN201310607482.2A
Authority: CN
Inventors: 高飞
Original assignee: Individual
Current assignee: Individual
Priority date: 2013-11-27
Filing date: 2013-11-27
Publication date: 2015-07-29
Anticipated expiration: 2033-11-27
Also published as: CN103599246A

Abstract

The invention discloses medicine of a kind of Cure for insomnia and preparation method thereof, it is mainly prepared from according to a certain weight ratio by Radix Angelicae Sinensis, Radix Angelicae Pubescentis, Caulis Spatholobi, Radix Codonopsis, Ramulus Cinnamomi, the Radix Astragali, Rhizoma Chuanxiong, Herba Asari, Radix Rehmanniae Preparata, medicine of the present invention has benefiting blood and regulating blood circulation, resolving heat and reducing pathogenic fire, the function of calming heart and tranquilizing mind, be used for the treatment of insomnia instant effect, short treating period, cure rate is high.

Description

Medicine of a kind of Cure for insomnia and preparation method thereof

Technical field

The present invention relates to a kind of medicine being used for the treatment of insomnia and preparation method thereof, belong to the field of Chinese medicines.

Technical background

Insomnia refers to fall asleep and maybe cannot keep sleep state, causes not having enough sleep.Also known as DIMS, for a variety of causes cause that difficulty falling asleep, Depth of sleep or frequency are too short, early awakening and the length of one's sleep not enough or of poor quality etc., be a kind of commonly encountered diseases.Insomnia the lighter difficulty falling asleep, or sleep but not soundly, sometimes sleeping and sometimes waking, or can not sleep again after waking up heavy then be insomnia all night.Insomnia is one of common clinical disease, though do not belong to critical illness, hinders people orthobiosis, work, study and health, and can increase the weight of or bring out the diseases such as cardiopalmus, the thoracic obstruction, dizzy, headache, apoplexy.Obstinate insomnia, brings long-term misery to patient, at present, western medicine insomnia poor effect, and long-term taking Western medicine can produce dependence to medicine, abuses insomnia drug simultaneously and can cause damage to other positions of health, therefore, there is very large demand to the Chinese medicine of effective Cure for insomnia in people.

Summary of the invention

The present inventor, according to the research of theory of Chinese medical science and clinical test repeatedly and checking, finally have found the medicine of effective Cure for insomnia, thus completes the present invention.

Object of the present invention be just to provide a kind of can the composition of medicine of effective Cure for insomnia.

Another object of the present invention just there is provided the preparation method of this composition of medicine.

Medicine of the present invention selects Radix Angelicae Sinensis, Radix Angelicae Pubescentis, Caulis Spatholobi, Radix Codonopsis, Ramulus Cinnamomi, the Radix Astragali, Rhizoma Chuanxiong, Herba Asari, Radix Rehmanniae Preparata, Pericarpium Citri Reticulatae, Flos Carthami, Radix Salviae Miltiorrhizae, the Cortex Eucommiae, Radix Achyranthis Bidentatae, Radix Glycyrrhizae, Herba potentillae fulgentis, Os Draconis medicine to combine, these drug regimens are made each efficacy of drugs produce synergism, thus can fast treating insomnia recurrence.Wherein select Radix Angelicae Sinensis to be because its nature and flavor sweet, acrid, warm, enter the heart, liver, spleen channel, have benefiting blood and regulating blood circulation, menstruction regulating and pain relieving, moisturize the function of laxation, control menoxenia, amenorrhea stomachache ， mass in the abdomen knot is poly-, metrorrhagia, and headache due to deficiency of blood is dizzy, flaccidity syndrome and arthralgia syndrome, dryness of the intestine difficulty is just, heavy after bloody dysentery, ulcer sores, incised wound, injury from falling down.Select Radix Angelicae Pubescentis to be that temperature, enters kidney, urinary bladder channel, dispel the wind because its nature and flavor are worked hard, victory is wet, cold expelling, and the function of pain relieving, controls anemofrigid-damp arthralgia, waist urushic acid pain, trick spasm and pain, chronic tracheitis, headache, toothache.Select Caulis Spatholobi to be because its property bitter but sweet flavor, temperature, enters the heart, spleen two warp, have invigorate blood circulation, the function of relaxing muscles and tendons, control soreness of waist and knee joint, paralysis and numbness, menoxenia.Select Radix Codonopsis to be because its nature and flavor are sweet, flat, start with, meridian of Foot-TAI YIN edema caused by disorder of QI, have invigorating the spleen and replenishing QI, the function of promoting the production of body fluid, controls weakness of the spleen and stomach, deficiency of both QI and blood, fatigue and lack of strength, and lack of appetite is thirsty, chronic diarrhea, proctoptosis.Select Ramulus Cinnamomi to be because its property acrid-sweet flavor, temperature, enter bladder, the heart, lung meridian, have diaphoresis expelling pathogenic factors from muscles, the function of warming the meridian and promoting blood circulation, controls exterior syndrome due to wind-cold, shoulder back of the body podomere ache, thoracic obstruction phlegm retention, amenorrhea and mass in the abdomen.Select the Radix Astragali to be that tepor, enters lung, spleen channel because its nature and flavor are sweet, life defends consolidating superficial resistance with useful, inducing diuresis to remove edema, poison holding, and the function of granulation promoting, controls spontaneous perspiration, night sweat, arthralgia due to stagnation of blood, edema, and carbuncle is not burst or burst and holds back for a long time; Processing the function with there being invigorating middle warmer benefit, controlling internal injury overstrain, diarrhea due to hypofunction of the spleen, proctoptosis, deficiency of vital energy blood prostration, the disease of metrorrhagia and leukorrhagia and all weakness of QI blood deficiency.Select Rhizoma Chuanxiong to be that temperature, enters liver, gallbladder meridian, have activating QI to alleviate the depression, dispeiling pathogenic wind and removing dampness, the function of promoting blood circulation and stopping pain, control air-cooled headache and revolve dizzy because its nature and flavor are pungent, hypochondriac pain abdomen aches, arthralgia due to cold clonic spasm of the muscle, amenorrhea, difficult labour, postpartum stagnation block pain, ulcer sores.Select Herba Asari to be that temperature, enters lung, kidney channel, dispel the wind, cold expelling, row water because its nature and flavor are pungent, open the function of stealing, control air-cooled headache, nasal sinusitis, pain relieving, phlegm retention cough with dyspnea, rheumatic arthralgia.Select Radix Rehmanniae Preparata to be that tepor, enters liver, kidney channel, have YIN nourishing, and the function of enriching blood controls deficiency of YIN insufficiency of blood, waist knee flaccidity, chronic cough hectic fever due to YIN-deficiency because its nature and flavor are sweet, seminal emission, metrorrhagia, menoxenia, quenches one's thirst, frequency of micturition, deaf, blurred vision.Pericarpium Citri Reticulatae is selected to be that temperature, return lung, spleen channel, have regulating qi-flowing for strengthening spleen, the function of drying dampness to eliminate phlegm, controls fullness in the epigastrium and chest, lack of appetite and vomiting, cough with copious phlegm because its nature and flavor are bitter, pungent.Select Flos Carthami to be that temperature, enters the heart, Liver Channel, have promoting blood circulation to restore menstrual flow, the function of blood stasis removing pain relieving, control amenorrhea ， mass in the abdomen because its nature and flavor are pungent, difficult labour, stillborn fetus, disease that postpartum lochia can't go, blood stasis is had a pain, carbuncle, injury from falling down.Radix Salviae Miltiorrhizae is selected to be that tepor, enters the heart, Liver Channel, have blood circulation and promoting silt, calming heart and tranquilizing mind, evacuation of pus, and the function of pain relieving, controls angina pectoris, menoxenia, dysmenorrhea, and to close, metrorrhagia leukorrhagia ， mass in the abdomen, gathers, abdominal pain due to blood stasis, arthralgia because its nature and flavor are bitter, palpitation with fear sleeplessness, malignant boil toxic swelling.Select the Cortex Eucommiae be because its nature and flavor sweet micro-pungent, temperature, enter liver, kidney channel, have invigorating the liver and kidney, bone and muscle strengthening, antiabortive function, control spinal column ache, foot and knee flaccidity, dribbling urination, uncontrolled urination is itched, vaginal bleeding during pregnancy for falling, hypertension.Select Radix Achyranthis Bidentatae to be because its nature and flavor sweetness and bitterness acid, flat, enter liver, kidney channel, dissipating blood stasis blood is used in life, and the function of subduing inflammation, controls gonorrhea, hematuria, amenorrhea ， mass in the abdomen, difficult labour, retention of placenta, postnatal blood stasis is suffered from abdominal pain, sore throat, carbuncle, traumatic injury, ripe invigorating the liver and kidney, bone and muscle strengthening, controls waist kneecap pain, spasm of the limbs, flaccidity syndrome and arthralgia syndrome.Radix Glycyrrhizae is selected to be because its nature and flavor are sweet, flat, enter spleen, stomach, lung meridian, have and middle emergency, lung moistening, removing toxic substances, the function of coordinating the actions of various ingredients in a prescription; Process use, control taste lack of appetite, stomachache loose stool, overstrain generates heat, and consumptive lung disease is coughed, cardiopalmus ， Jing Epilepsy; Raw use, controls laryngopharynx swelling and pain, peptic ulcer, carbuncle subcutaneous ulcer skin infection, separates poison of drug and alimentary toxicosis.Select Herba potentillae fulgentis to be that bitter and puckery flavor, has heat clearing and inflammation relieving, and the function of cooling blood for hemostasis, controls dysentery, enteritis because its nature and flavor are trembled with fear, stomachache, hemoptysis of pulmonary tuberculosis, epistaxis, has blood in stool, metrorrhagia, traumatic hemorrhage, furuncle.Select Os Draconis to be because its property sweet-puckery flavor, flat, be included into the heart, liver, kidney, large intestine channel, have tranquillizing the mind by relieving convulsion, the function of arresting sweating controlling nocturnal emission with astringent drugs, control frightened Epilepsy demented, palpitation with a distress feeling is forgetful, insomnia and dreamful sleep, spontaneous sweating.

The drug dose of the present invention's combination is also that inventor draws through groping in a large number to sum up, and the consumption of each component all has good therapeutic effect within the scope of following weight

Radix Angelicae Sinensis 10-20 gram of Radix Angelicae Pubescentis 15-25 gram of Caulis Spatholobi 15-25 gram

Radix Codonopsis 10-20 gram of Ramulus Cinnamomi 5-15 gram of Radix Astragali 10-20 gram

Rhizoma Chuanxiong 5-15 gram of Herba Asari 15-25 gram of Radix Rehmanniae Preparata 15-25 gram

Pericarpium Citri Reticulatae 5-15 gram of Flos Carthami 5-15 gram of Radix Salviae Miltiorrhizae 15-25 gram

Cortex Eucommiae 10-20 gram of Radix Achyranthis Bidentatae 15-25 gram of Radix Glycyrrhizae 3-9 gram

Herba potentillae fulgentis 15-25 cron bone 25-35 gram

Preferable amount is

Radix Angelicae Sinensis 15 grams of Radix Angelicae Pubescentiss 20 grams of Caulis Spatholobis 20 grams

Radix Codonopsis 15 grams of Ramulus Cinnamomi 10 grams of Radixs Astragali 15 grams

Rhizoma Chuanxiong 10 grams of Herba Asaris 20 grams of Radix Rehmanniae Preparata 20 grams

Pericarpium Citri Reticulatae 10 grams of Flos Carthamis 10 grams of Radix Salviae Miltiorrhizaes 20 grams

6 grams, the Cortex Eucommiae 15 grams of Radix Achyranthis Bidentataes 20 grams of Radix Glycyrrhizaes

30 grams, Herba potentillae fulgentis 20 cron bone

The preparation method of medicine of the present invention is as follows

One, get the raw materials ready

1, Radix Angelicae Sinensis: pick decontamination, clean, moistening, when slightly drying in the air even to inside and outside humidity, section is dried;

2, Radix Angelicae Pubescentis: pick decontamination, separately size, clean, run through rear section, dry;

3, Caulis Spatholobi: run through with water, section, or steam soft after take advantage of fervent sheet, dry;

4, Radix Codonopsis: run through reed after cleaning silt, section or cutting, dry;

5, Ramulus Cinnamomi: slightly soak with water, pulls out, and moistening, to thoroughly, is cut into slices, dried, sieve anti-dandruff;

6, the Radix Astragali: pick clean impurity, the root head that removing is residual and hollow the greater, be soaked in water, pull out, run through rear timely section, dry;

7, Rhizoma Chuanxiong: pick decontamination, separately large and small, be soaked in water, solarization is dried in the air, and cuts into slices after moistening, dry;

8, Herba Asari: Ex-all impurity, by water spray profit, timely cutting, dries;

9, Radix Rehmanniae Preparata: get crude drug, steams to surperficial corvinus, takes out, when shining dry to eighty per cant, and section, dry;

10, Pericarpium Citri Reticulatae: get crude drug, the peel of removing impurity and blackening, wash quickly is clean, softens, shredding, dries or cold drying, sieve dedust bits;

11, Flos Carthami: pick clean impurity, removing stem and leaf, base of a fruit head, dry;

12, Radix Salviae Miltiorrhizae: pick clean impurity, removing rhizome, cleans, pulls out, run through rear section, dry;

13, the Cortex Eucommiae: removing rough bark, clean, run through, dice or strand, dry;

14, Radix Achyranthis Bidentatae: pick decontamination, cleans, softens, go reed, cutting, dry;

15, Radix Glycyrrhizae: pick decontamination, cleans, and when being soaked in water saturating to eighty per cant, pulling out, runs through section, dry;

16, Herba potentillae fulgentis: pick decontamination, dries;

17, Os Draconis: outwash earth, smash.

Two, prepare

1, by the Radix Angelicae Sinensis of described weight, Radix Angelicae Pubescentis, Caulis Spatholobi, Radix Codonopsis, Ramulus Cinnamomi, the Radix Astragali, Rhizoma Chuanxiong, Herba Asari, Radix Rehmanniae Preparata, Pericarpium Citri Reticulatae, Flos Carthami, Radix Salviae Miltiorrhizae, the Cortex Eucommiae, Radix Achyranthis Bidentatae, Radix Glycyrrhizae, Herba potentillae fulgentis, Os Draconis medicine, add water 10 times amount, soak after 200 minutes, intense fire decocts boiling 30 minutes, use slow fire boiling again 40 minutes, filter first time decoction liquor.

2, add water the medicinal residues of filtration 6 times amount, and intense fire boils, then uses slow fire boiling 30 minutes, filters to obtain second time decoction liquor.

3, merge secondary decoction liquor, intense fire boils, then with slow fire boiling 10 minutes and get final product, is divided into by medicinal liquid 3 doses to take.

Medicine of the present invention has benefiting blood and regulating blood circulation, resolving heat and reducing pathogenic fire, and the function of calming heart and tranquilizing mind, is used for the treatment of insomnia, short treating period, instant effect, has no side effect.

Detailed description of the invention

Set forth the beneficial effect of medicine of the present invention further below by way of test example, these test examples include animal toxicity test report and the clinical observation material of medicine of the present invention.

The animal toxicity test report of [test example 1] medicine of the present invention

Get rabbit 30, male and female dual-purpose, body weight 2.0-2.4kg, divide two groups, often organize 15, wherein one group is overdose test group, and another group is normal amount test group.Super quantity group is 20ml/kg, and normal amount is 10ml/kg, and administering mode is administration by gavage administration, and every day, secondary, serve on 7 days, observes administration reaction every day, and result shows that two groups of rabbit are movable, diet is normal, and medicine is without bad toxic and side effects.

The observations of [test example 2] Drug therapy insomnia of the present invention

1, physical data

Accept insomniac's totally 265 examples for medical treatment.

2, diagnostic criteria

Insomnia:

(1) difficulty falling asleep;

(2) can not sleep soundly, the length of one's sleep reduces;

(3) early awakening, wake up after cannot fall asleep again;

(4) again and again wake from a nightmare with a start, self-induction is all being had nightmares whole night;

(5) energy afterwards of sleeping does not recover;

(6) disease time is changeable, and short person's a couple of days can take a turn for the better, and elder's last for days is difficult to recover;

(7) easily waken up with a start, have to sound sensitive, what have is responsive to light;

(8) people of a lot of insomnia is fond of daydreams;

(9) insomnia can cause neurasthenia and depression for a long time, and the disease of neurastheniac can increase the weight of insomnia.

3, Therapeutic Method

Select above-mentioned medicament, take to patient, each serving with 1 dose, every day is early, middle and late respectively takes 1 time, within 7 days, is a course for the treatment of, takes 3 courses for the treatment of continuously.

4, efficacy assessment standard

Effective: insomnia disappears, observe half a year without bounce-back person;

Take a turn for the better: insomnia obviously improves, and body constitution progressively strengthens;

Invalid: insomnia, without change, does not reach improvement standard person.

5, therapeutic outcome (seeing the following form)

In above-mentioned treatment, by Drug therapy insomniac 265 example of the present invention, effective 255 examples of result, obvious effective rate is 96.23%, and take a turn for the better 6 examples, and improvement rate is 2.26%, and invalid 4 examples, total effective rate is 98.49%.

Claims

1. a medicine for Cure for insomnia, is characterized in that: it is made up of the crude drug in following weight range:

Herba potentillae fulgentis 15-25 cron bone 25-35 gram.

2. medicine according to claim 1, wherein the consumption of each crude drug is:

30 grams, Herba potentillae fulgentis 20 cron bone.

3. the preparation method of medicine according to claim 1 or 2, is characterized in that: it comprises the following steps:

(1) get the raw materials ready

(1) Radix Angelicae Sinensis: pick decontamination, clean, moistening, when slightly drying in the air even to inside and outside humidity, section is dried;

(2) Radix Angelicae Pubescentis: pick decontamination, separately size, clean, run through rear section, dry;

(3) Caulis Spatholobi: run through with water, section, or steam soft after take advantage of fervent sheet, dry;

(4) Radix Codonopsis: run through reed after cleaning silt, section or cutting, dry;

(5) Ramulus Cinnamomi: slightly soak with water, pulls out, and moistening, to thoroughly, is cut into slices, dried, sieve anti-dandruff;

(6) Radix Astragali: pick clean impurity, the root head that removing is residual and hollow the greater, be soaked in water, pull out, run through rear timely section, dry;

(7) Rhizoma Chuanxiong: pick decontamination, separately large and small, be soaked in water, solarization is dried in the air, and cuts into slices after moistening, dry;

(8) Herba Asari: Ex-all impurity, by water spray profit, timely cutting, dries;

(9) Radix Rehmanniae Preparata: get crude drug, steams to surperficial corvinus, takes out, when shining dry to eighty per cant, and section, dry;

(10) Pericarpium Citri Reticulatae: get crude drug, the peel of removing impurity and blackening, wash quickly is clean, softens, shredding, dries or cold drying, sieve dedust bits;

(11) Flos Carthami: pick clean impurity, removing stem and leaf, base of a fruit head, dry;

(12) Radix Salviae Miltiorrhizae: pick clean impurity, removing rhizome, cleans, pulls out, run through rear section, dry;

(13) Cortex Eucommiae: removing rough bark, clean, run through, dice or strand, dry;

(14) Radix Achyranthis Bidentatae: pick decontamination, cleans, softens, go reed, cutting, dry;

(15) Radix Glycyrrhizae: pick decontamination, cleans, and when being soaked in water saturating to eighty per cant, pulling out, runs through section, dry;

(16) Herba potentillae fulgentis: pick decontamination, dries;

(17) Os Draconis: outwash earth, smash;

(2) prepare

(1) by the Radix Angelicae Sinensis of described weight, Radix Angelicae Pubescentis, Caulis Spatholobi, Radix Codonopsis, Ramulus Cinnamomi, the Radix Astragali, Rhizoma Chuanxiong, Herba Asari, Radix Rehmanniae Preparata, Pericarpium Citri Reticulatae, Flos Carthami, Radix Salviae Miltiorrhizae, the Cortex Eucommiae, Radix Achyranthis Bidentatae, Radix Glycyrrhizae, Herba potentillae fulgentis, Os Draconis medicine, add water 10 times amount, soak after 200 minutes, intense fire decocts boiling 30 minutes, use slow fire boiling again 40 minutes, filter first time decoction liquor;

(2) add water the medicinal residues of filtration 6 times amount, and intense fire boils, then uses slow fire boiling 30 minutes, filters to obtain second time decoction liquor;

(3) merge secondary decoction liquor, intense fire boils, then with slow fire boiling 10 minutes and get final product.