CN103599246A

CN103599246A - Drug for treating insomnia and preparation method of drug

Info

Publication number: CN103599246A
Application number: CN201310607482.2A
Authority: CN
Inventors: 高飞
Original assignee: Individual
Current assignee: Individual
Priority date: 2013-11-27
Filing date: 2013-11-27
Publication date: 2014-02-26
Anticipated expiration: 2033-11-27
Also published as: CN103599246B

Abstract

The invention discloses a drug for treating insomnia and a preparation method of the drug. The drug is prepared from the raw materials in a certain weight ratio: angelica sinensis, radix angelicae pubescentis, caulis spatholobi, codonopsis pilosula, cassia twig, astragalus membranaceus, ligusticum wallichii, asarum and prepared rehmannia root. The drug has the functions of enriching blood, regulating qi and the blood, clearing the inner heat, soothing nerves and calming a heart and has quick effect, short treatment course and high curative ratio when being used for treating the insomnia.

Description

Medicine of a kind of Cure for insomnia and preparation method thereof

Technical field

The present invention relates to a kind of medicine that is used for the treatment of insomnia and preparation method thereof, belong to the field of Chinese medicines.

Technical background

Insomnia refers to fall asleep and maybe cannot keep sleep state, causes not having enough sleep.Claim again DIMS, for a variety of causes causes that difficulty falling asleep, Depth of sleep or frequency are too short, early awakening and the length of one's sleep not enough or of poor quality etc., be a kind of commonly encountered diseases.Insomnia the lighter difficulty falling asleep, or sleep but not soundly, sometimes sleeping and sometimes waking, or can not sleep again after waking up heavy be insomnia all night.Insomnia is one of common clinical disease, though do not belong to critical illness, hinders people orthobiosis, work, study and health, and can increase the weight of or bring out the diseases such as cardiopalmus, the thoracic obstruction, dizzy, headache, apoplexy.Obstinate insomnia, brings long-term misery to patient, at present, western medicine insomnia poor effect, and long-term taking Western medicine can produce dependence to medicine, abuses insomnia drug simultaneously and can cause damage to other positions of health, therefore there is very large demand to the Chinese medicine of effective Cure for insomnia in people.

Summary of the invention

The inventor, according to the research of theory of Chinese medical science and clinical test and checking repeatedly, has finally found the medicine of effective Cure for insomnia, thereby has completed the present invention.

Object of the present invention is just to provide a kind of effectively composition of medicine of Cure for insomnia.

Another object of the present invention has just been to provide the preparation method of this composition of medicine.

Medicine of the present invention selects Radix Angelicae Sinensis, Radix Angelicae Pubescentis, Caulis Spatholobi, Radix Codonopsis, Ramulus Cinnamomi, the Radix Astragali, Rhizoma Chuanxiong, Herba Asari, Radix Rehmanniae Preparata, Pericarpium Citri Reticulatae, Flos Carthami, Radix Salviae Miltiorrhizae, the Cortex Eucommiae, Radix Achyranthis Bidentatae, Radix Glycyrrhizae, Herba potentillae fulgentis, Os Draconis medicine to combine, make each efficacy of drugs produce synergism these drug regimens, thus recurrence that can fast treating insomnia.Wherein select Radix Angelicae Sinensis to be because its nature and flavor sweet, acrid, warm enters the heart, liver, spleen channel, have benefiting blood and regulating blood circulation, menstruction regulating and pain relieving, the function of moisturizing laxation, control menoxenia, amenorrhea stomachache ， mass in the abdomen knot is poly-, metrorrhagia, and headache due to deficiency of blood, dizzy, flaccidity syndrome and arthralgia syndrome, dryness of the intestine difficulty just, heavy after bloody dysentery, ulcer sores, incised wound, injury from falling down.Select Radix Angelicae Pubescentis to be because its nature and flavor are arduous, temperature, enters kidney, urinary bladder channel, dispels the wind, and victory is wet, cold expelling, and the function of pain relieving, controls anemofrigid-damp arthralgia, waist urushic acid pain, trick spasm and pain, chronic tracheitis, headache, toothache.Selecting Caulis Spatholobi is because its property bitter but sweet flavor, and temperature, enters the heart, spleen two warps, have invigorate blood circulation, the function of relaxing muscles and tendons, control soreness of waist and knee joint, paralysis and numbness, menoxenia.Select Radix Codonopsis to be because its nature and flavor are sweet, flat, start with, meridian of Foot-TAI YIN edema caused by disorder of QI, have invigorating the spleen and replenishing QI, the function of promoting the production of body fluid, controls weakness of the spleen and stomach, deficiency of both QI and blood, and fatigue and lack of strength, lack of appetite, thirsty, chronic diarrhea, proctoptosis.Selecting Ramulus Cinnamomi is that temperature, enters bladder, the heart, lung meridian, has diaphoresis expelling pathogenic factors from muscles because of its property acrid-sweet flavor, and the function of warming the meridian and promoting blood circulation, controls exterior syndrome due to wind-cold, shoulder back of the body podomere ache, thoracic obstruction phlegm retention, amenorrhea and mass in the abdomen.Select the Radix Astragali to be because its nature and flavor are sweet, tepor, enters lung, spleen channel, raw with the useful consolidating superficial resistance of defending, inducing diuresis to remove edema, and poison holding, the function of granulation promoting, controls spontaneous perspiration, night sweat, arthralgia due to stagnation of blood, edema, carbuncle is not burst or is burst and hold back for a long time; Process by the function that has invigorating middle warmer benefit, control internal injury overstrain, diarrhea due to hypofunction of the spleen, proctoptosis, deficiency of vital energy blood prostration, the disease of metrorrhagia and leukorrhagia and all weakness of QI blood deficiency.Select Rhizoma Chuanxiong to be because its nature and flavor are pungent, temperature, enters liver, gallbladder meridian, has activating QI to alleviate the depression, dispeiling pathogenic wind and removing dampness, the function of promoting blood circulation and stopping pain, control air-cooled headache revolve dizzy, hypochondriac pain abdomen pain, arthralgia due to cold clonic spasm of the muscle, amenorrhea, difficult labour, postpartum stagnation piece pain, ulcer sores.Select Herba Asari to be because its nature and flavor are pungent, temperature, enters lung, kidney channel, dispel the wind, and cold expelling, row water, opens the function of stealing, and controls air-cooled headache, nasal sinusitis, pain relieving, phlegm retention cough with dyspnea, rheumatic arthralgia.Select Radix Rehmanniae Preparata to be because its nature and flavor are sweet, tepor, enters liver, kidney channel, has YIN nourishing, and the function of enriching blood is controlled deficiency of YIN insufficiency of blood, waist knee flaccidity, and chronic cough hectic fever due to YIN-deficiency, seminal emission, metrorrhagia, menoxenia, quenches one's thirst, frequency of micturition, deafness, blurred vision.Select Pericarpium Citri Reticulatae to be because its nature and flavor are bitter, pungent, temperature, returns lung, spleen channel, has regulating qi-flowing for strengthening spleen, and the function of drying dampness to eliminate phlegm, controls fullness in the epigastrium and chest, lack of appetite and vomiting, cough with copious phlegm.Select Flos Carthami to be because its nature and flavor are pungent, temperature, enters the heart, Liver Channel, has promoting blood circulation to restore menstrual flow, and the function of blood stasis removing pain relieving is controlled amenorrhea ， mass in the abdomen, difficult labour, and stillborn fetus, disease that postpartum lochia can't go, blood stasis is had a pain, carbuncle, injury from falling down.Select Radix Salviae Miltiorrhizae to be because its nature and flavor are bitter, tepor, enters the heart, Liver Channel, has blood circulation and promoting silt, calming heart and tranquilizing mind, and evacuation of pus, the function of pain relieving, controls angina pectoris, menoxenia, dysmenorrhea, to close, metrorrhagia leukorrhagia ， mass in the abdomen, gathers, abdominal pain due to blood stasis, arthralgia, palpitation with fear sleeplessness, malignant boil toxic swelling.Select the Cortex Eucommiae to be because its nature and flavor are sweet micro-pungent, temperature, enters liver, kidney channel, has invigorating the liver and kidney, bone and muscle strengthening, and antiabortive function, controls spinal column ache, foot and knee flaccidity, dribbling urination, uncontrolled urination is itched, and vaginal bleeding during pregnancy is wanted to fall, hypertension.Select Radix Achyranthis Bidentatae to be because its nature and flavor sweetness and bitterness acid is flat, enter liver, kidney channel, dissipating blood stasis blood is used in life, and the function of subduing inflammation, controls gonorrhea, hematuria, amenorrhea ， mass in the abdomen, difficult labour, retention of placenta, postnatal blood stasis stomachache, sore throat, carbuncle, traumatic injury, ripe in invigorating the liver and kidney, bone and muscle strengthening, controls waist kneecap pain, spasm of the limbs, flaccidity syndrome and arthralgia syndrome.Select Radix Glycyrrhizae to be because its nature and flavor are sweet, flat, enter spleen, stomach, lung meridian, there are and middle emergency lung moistening, removing toxic substances, the function of coordinating the actions of various ingredients in a prescription; Process use, control taste lack of appetite, stomachache loose stool, overstrain heating, consumptive lung disease cough, cardiopalmus ， Jing Epilepsy; Raw use, controls laryngopharynx swelling and pain, peptic ulcer, and carbuncle subcutaneous ulcer skin infection, separates poison of drug and alimentary toxicosis.Select Herba potentillae fulgentis to be because its nature and flavor are cold, bitter and puckery flavor, has heat clearing and inflammation relieving, and the function of cooling blood for hemostasis, controls dysentery, enteritis, and stomachache, hemoptysis of pulmonary tuberculosis, epistaxis, has blood in stool, metrorrhagia, traumatic hemorrhage, furuncle.Select Os Draconis to be because its property sweet-puckery flavor is flat, be included into the heart, liver, kidney, large intestine channel, have tranquillizing the mind by relieving convulsion, the function of arresting sweating controlling nocturnal emission with astringent drugs, controls frightened Epilepsy demented, and palpitation with a distress feeling is forgetful, insomnia and dreamful sleep, spontaneous sweating.

The drug dose of the present invention's combination is also that inventor draws through groping in a large number to sum up, and the consumption of each component all has good therapeutic effect within the scope of following weight

Radix Angelicae Sinensis 10-20 gram of Radix Angelicae Pubescentis 15-25 gram of Caulis Spatholobi 15-25 gram

Radix Codonopsis 10-20 gram of Ramulus Cinnamomi 5-15 gram of Radix Astragali 10-20 gram

Rhizoma Chuanxiong 5-15 gram of Herba Asari 15-25 gram of Radix Rehmanniae Preparata 15-25 gram

Pericarpium Citri Reticulatae 5-15 gram of Flos Carthami 5-15 gram of Radix Salviae Miltiorrhizae 15-25 gram

Cortex Eucommiae 10-20 gram of Radix Achyranthis Bidentatae 15-25 gram of Radix Glycyrrhizae 3-9 gram

Herba potentillae fulgentis 15-25 cron bone 25-35 gram

Preferable amount is

20 grams of 20 grams of Caulis Spatholobis of 15 grams of Radix Angelicae Pubescentiss of Radix Angelicae Sinensis

15 grams of 10 grams of Radixs Astragali of 15 grams of Ramulus Cinnamomi of Radix Codonopsis

20 grams of 20 grams of Radix Rehmanniae Preparata of 10 grams of Herba Asaris of Rhizoma Chuanxiong

20 grams of 10 grams of Radix Salviae Miltiorrhizaes of 10 grams of Flos Carthamis of Pericarpium Citri Reticulatae

6 grams, 20 grams of Radix Glycyrrhizaes of 15 grams of Radix Achyranthis Bidentataes of the Cortex Eucommiae

30 grams, Herba potentillae fulgentis 20 cron bone

The preparation method of medicine of the present invention is as follows

One, get the raw materials ready

1, Radix Angelicae Sinensis: choose decontamination, clean, moistening, slightly dries in the air when even to inside and outside humidity, and section is dried;

2, Radix Angelicae Pubescentis: choose decontamination, separately size, cleans, and runs through rear section, dry;

3, Caulis Spatholobi: water runs through, section, or steam after soft and take advantage of fervent sheet, dry;

4, Radix Codonopsis: run through reed after cleaning silt, section or cutting, dry;

5, Ramulus Cinnamomi: water slightly soaks, pulls out, and moistening, to thoroughly, is cut into slices, and dries, and sieves anti-dandruff;

6, the Radix Astragali: choose clean impurity, remove residual root head and hollow the greater, be soaked in water, pull out, run through rear timely section, dry;

7, Rhizoma Chuanxiong: choose decontamination, separate large and small, be soaked in water, solarization is dried in the air, and cuts into slices after moistening, dry;

8, Herba Asari: Ex-all impurity, water spray profit, cutting in time, dries;

9, Radix Rehmanniae Preparata: get crude drug, steam to surperficial corvinus, take out, shines when dry to eighty per cant, section, is dried;

10, Pericarpium Citri Reticulatae: get crude drug, remove the peel of impurity and blackening, wash quickly is clean, softens, and shredding, dries or cold drying, sieve dedust bits;

11, Flos Carthami: choose clean impurity, remove stem and leaf, base of a fruit head, dry;

12, Radix Salviae Miltiorrhizae: choose clean impurity, remove rhizome, clean, pull out, run through rear section, dry;

13, the Cortex Eucommiae: remove rough bark, clean, run through, dice or strand, dry;

14, Radix Achyranthis Bidentatae: choose decontamination, clean, soften, go reed, cutting, dries;

15, Radix Glycyrrhizae: choose decontamination, clean, be soaked in water and, pull out thoroughly time to eighty per cant, run through section, dry;

16, Herba potentillae fulgentis: choose decontamination, dry;

17, Os Draconis: outwash earth, smash.

Two, preparation

1, by the Radix Angelicae Sinensis of described weight, Radix Angelicae Pubescentis, Caulis Spatholobi, Radix Codonopsis, Ramulus Cinnamomi, the Radix Astragali, Rhizoma Chuanxiong, Herba Asari, Radix Rehmanniae Preparata, Pericarpium Citri Reticulatae, Flos Carthami, Radix Salviae Miltiorrhizae, the Cortex Eucommiae, Radix Achyranthis Bidentatae, Radix Glycyrrhizae, Herba potentillae fulgentis, Os Draconis medicine, add 10 times of amounts of water, soak after 200 minutes, intense fire decocts boiling 30 minutes, use again slow fire boiling 40 minutes, filter to obtain decoction liquor for the first time.

2, the medicinal residues of filtration are added to 6 times of amounts of water, intense fire boils, then uses slow fire boiling 30 minutes, filters to obtain decoction liquor for the second time.

3, merge secondary decoction liquor, intense fire boils, then with slow fire boiling 10 minutes and get final product, medicinal liquid is divided into 3 doses and takes.

Medicine of the present invention has benefiting blood and regulating blood circulation, resolving heat and reducing pathogenic fire, and the function of calming heart and tranquilizing mind, is used for the treatment of insomnia, short treating period, instant effect, has no side effect.

The specific embodiment

By test example, further set forth below the beneficial effect of medicine of the present invention, these test examples have comprised animal toxicity test report and the clinical observation material of medicine of the present invention.

The animal toxicity test report of [test example 1] medicine of the present invention

Get 30 of rabbit, male and female dual-purpose, body weight 2.0-2.4kg, divides two groups, and 15 every group, wherein one group is overdose test group, and another group is normal amount test group.Super quantity group is 20ml/kg, and normal amount is 10ml/kg, and administering mode is administration by gavage administration, and every day, secondary, serve on 7 days, observes administration reaction every day, and result shows that two groups of rabbit are movable, diet is normal, and medicine is without bad toxic and side effects.

The observations of [test example 2] Drug therapy insomnia of the present invention

1, physical data

Accept insomniac's totally 265 examples for medical treatment.

2, diagnostic criteria

Insomnia:

(1) difficulty falling asleep;

(2) can not sleep soundly, reduce the length of one's sleep;

(3) early awakening, cannot fall asleep again after waking up;

(4) again and again wake from a nightmare with a start, self-induction is all being had nightmares whole night;

(5) slept after energy do not recover;

(6) disease time is changeable, and short person can take a turn for the better a couple of days, and elder is difficult to recover at the lasting a few days;

(7) easily waken up with a start, have to sound sensitive, what have is responsive to light;

(8) people of a lot of insomnias is fond of daydreams;

(9) insomnia can cause neurasthenia and depression for a long time, and the disease of neurastheniac can increase the weight of insomnia.

3, Therapeutic Method

Select above-mentioned medicament, to patient, take, each serving with 1 dose, every day, early, middle and late respectively clothes 1 time, 7 days was a course for the treatment of, took continuously 3 courses for the treatment of.

4, efficacy assessment standard

Effective: insomnia disappears, observe half a year without bounce-back person;

Take a turn for the better: insomnia obviously improves, and body constitution progressively strengthens;

Invalid: insomnia, without change, does not reach improvement standard person.

5, therapeutic outcome (seeing the following form)

Figure 2013106074822100002DEST_PATH_IMAGE001

In above-mentioned treatment, by Drug therapy insomniac's 265 examples of the present invention, effective 255 examples of result, obvious effective rate is 96.23%, 6 examples that take a turn for the better, and improvement rate is 2.26%, invalid 4 examples, total effective rate is 98.49%.

Claims

1. a medicine for Cure for insomnia, is characterized in that: it is to be made by the crude drug in following weight range:

Herba potentillae fulgentis 15-25 cron bone 25-35 gram.

2. medicine according to claim 1, wherein the consumption of each crude drug is:

30 grams, Herba potentillae fulgentis 20 cron bone.

3. according to the preparation method of medicine described in claim 1 or 2, it is characterized in that: it comprises the following steps:

(1) get the raw materials ready

(1) Radix Angelicae Sinensis: choose decontamination, clean, moistening, slightly dries in the air when even to inside and outside humidity, and section is dried;

(2) Radix Angelicae Pubescentis: choose decontamination, separately size, cleans, and runs through rear section, dry;

(3) Caulis Spatholobi: water runs through, section, or steam after soft and take advantage of fervent sheet, dry;

(4) Radix Codonopsis: run through reed after cleaning silt, section or cutting, dry;

(5) Ramulus Cinnamomi: water slightly soaks, pulls out, and moistening, to thoroughly, is cut into slices, and dries, and sieves anti-dandruff;

(6) Radix Astragali: choose clean impurity, remove residual root head and hollow the greater, be soaked in water, pull out, run through rear timely section, dry;

(7) Rhizoma Chuanxiong: choose decontamination, separate large and small, be soaked in water, solarization is dried in the air, and cuts into slices after moistening, dry;

(8) Herba Asari: Ex-all impurity, water spray profit, cutting in time, dries;

(9) Radix Rehmanniae Preparata: get crude drug, steam to surperficial corvinus, take out, shines when dry to eighty per cant, section, is dried;

(10) Pericarpium Citri Reticulatae: get crude drug, remove the peel of impurity and blackening, wash quickly is clean, softens, and shredding, dries or cold drying, sieve dedust bits;

(11) Flos Carthami: choose clean impurity, remove stem and leaf, base of a fruit head, dry;

(12) Radix Salviae Miltiorrhizae: choose clean impurity, remove rhizome, clean, pull out, run through rear section, dry;

(13) Cortex Eucommiae: remove rough bark, clean, run through, dice or strand, dry;

(14) Radix Achyranthis Bidentatae: choose decontamination, clean, soften, go reed, cutting, dries;

(15) Radix Glycyrrhizae: choose decontamination, clean, be soaked in water and, pull out thoroughly time to eighty per cant, run through section, dry;

(16) Herba potentillae fulgentis: choose decontamination, dry;

(17) Os Draconis: outwash earth, smash;

(2) preparation

(1) by the Radix Angelicae Sinensis of described weight, Radix Angelicae Pubescentis, Caulis Spatholobi, Radix Codonopsis, Ramulus Cinnamomi, the Radix Astragali, Rhizoma Chuanxiong, Herba Asari, Radix Rehmanniae Preparata, Pericarpium Citri Reticulatae, Flos Carthami, Radix Salviae Miltiorrhizae, the Cortex Eucommiae, Radix Achyranthis Bidentatae, Radix Glycyrrhizae, Herba potentillae fulgentis, Os Draconis medicine, add 10 times of amounts of water, soak after 200 minutes, intense fire decocts boiling 30 minutes, use again slow fire boiling 40 minutes, filter to obtain decoction liquor for the first time;

(2) medicinal residues of filtration are added to 6 times of amounts of water, intense fire boils, then uses slow fire boiling 30 minutes, filters to obtain decoction liquor for the second time;

(3) merge secondary decoction liquor, intense fire boils, then with slow fire boiling 10 minutes and get final product.