CN103386010A

CN103386010A - Medicine used for treating sore and ulcer disease and preparation method thereof

Info

Publication number: CN103386010A
Application number: CN2013103096143A
Authority: CN
Inventors: 肖振锋
Original assignee: Individual
Current assignee: Individual
Priority date: 2013-07-23
Filing date: 2013-07-23
Publication date: 2013-11-13
Anticipated expiration: 2033-07-23
Also published as: CN103386010B

Abstract

The invention discloses a medicine used for treating a sore and ulcer disease and a preparation method thereof. The medicine is prepared mainly from Chinese angelica, pericarpium citri reticulatae, Chinese violet, honeysuckle flower, winter jasmine, and fritillaria cirrhosa according to a certain weight ratio. The medicine has functions of clearing away heat and draining dampness, clearing away toxic materials, removing swelling, promoting blood circulation and relieving pain. The medicine has rapid effectiveness, good curative effects and high cure rate when being used for treating the sore and ulcer disease.

Description

A kind of medicine for the treatment of skin infection and preparation method thereof

Technical field

The present invention relates to a kind of medicine for the treatment of skin infection and preparation method thereof, belong to the field of Chinese medicines.

Background technology

Skin infection is the common frequently-occurring disease of surgical clinical, and skin infection comprises all abscesss and ulcer, as carbuncle, and furuncle, furuncle and phyma, the tuberculosis of bone and joint, multiple abscess, scrofula is gone through etc.Be apt to occur in summer and autumn, the four seasons all can fall ill.The characteristics such as this type of disease is the clinical commonly encountered diseases frequently-occurring disease of surgery of Chinese medicine, has morbidity rapidly, and the part state of an illness is heavier, can cause furunche complicated with septicemia at face, easily causes the serious consequence of muscle and tendon injury damage bone at hands, foot.Wound has just formed skin infection after occurring infecting.At present, due to western medicine skin infection poor effect, and easily recurrence, and more side effect is arranged, therefore, there is very large demand in people to the Chinese medicine of effective treatment skin infection.

Summary of the invention

The inventor, according to the research of theory of Chinese medical science and clinical repeatedly test and checking, has finally found the medicine of effective treatment skin infection, thereby has completed the present invention.

Purpose of the present invention just is to provide a kind of composition of medicine that can effectively treat skin infection.

Another object of the present invention just has been to provide the preparation method of this composition of medicine.

Medicine of the present invention selects Radix Angelicae Sinensis, Pericarpium Citri Reticulatae, Herba Violae, Flos Lonicerae, Flos Jasmini Nudiflori, Bulbus Fritillariae Cirrhosae, Radix Saposhnikoviae, the Radix Angelicae Dahuricae, Olibanum, Myrrha, Squama Manis, Spina Gleditsiae medicine to make up, make each efficacy of drugs produce synergism these drug regimens, thereby can effectively treat the recurrence of skin infection.Wherein select Radix Angelicae Sinensis to be because its nature and flavor sweet, acrid, warm enters the heart, liver, spleen channel, benefiting blood and regulating blood circulation is arranged, menstruction regulating and pain relieving, the function of moisturizing laxation, control menoxenia, amenorrhea stomachache ， mass in the abdomen knot is poly-, metrorrhagia, and headache due to deficiency of blood, dizzy, flaccidity syndrome and arthralgia syndrome, dryness of the intestine difficulty are just, and be heavy after bloody dysentery, ulcer sores, incised wound, injury from falling down.Select Pericarpium Citri Reticulatae to be because its nature and flavor are bitter, hot, temperature, return lung, spleen channel, and regulating qi-flowing for strengthening spleen is arranged, and the function of drying dampness to eliminate phlegm, control fullness in the epigastrium and chest, lack of appetite and vomiting, cough with copious phlegm.Select Herba Violae to be because its nature and flavor are bitter, cold, enter the heart, Liver Channel, clearing away heat-damp and promoting diuresis is arranged, the function of removing toxic substances and promoting subsidence of swelling, control furuncle, carbuncle, scrofula, jaundice, dysentery, diarrhoea, conjunctival congestion, sore throat, venom.Select Flos Lonicerae to be because its nature and flavor are sweet, cold, enter lung, stomach warp, heat clearing away is arranged, the function of detoxifcation, control the epidemic febrile disease heating, toxic-heat and blood stasis, carbuncle and ulcer, toxic swelling, scrofula, anal fistula.Select Flos Jasmini Nudiflori to be because its nature and flavor are pained, flat, heat clearing away is arranged, the function of drawing out pus by applying a plaster to the affected part, cure mainly toxic swelling, malignant boil.Select Bulbus Fritillariae Cirrhosae to be because its property bitter but sweet flavor is cool, enter lung meridian, the lung moistening eliminating stagnation is arranged, the function that antitussive reduces phlegm, control cough due to consumptive disease, the spitting of blood of spitting, ambition pent-up, consumptive lung disease, lung abscess, goiter, scrofula, sore throat, acute mastitis.Selecting Radix Saposhnikoviae is that temperature, enter bladder, lung, spleen channel, delivers because of its property acrid-sweet flavor, dispels the wind, and victory is wet, and the function of pain relieving, control affection of exogenous wind-cold, and headache is dizzy, stiffness of the nape, and anemofrigid-damp arthralgia, joint is ached, and the extremity contraction is anxious, tetanus.Select the Radix Angelicae Dahuricae to be because its nature and flavor are hot, temperature, enter lung, spleen, stomach warp, dispel the wind, and dampness, detumescence, the function of pain relieving, control headache, supraorbital bone pain, toothache, nasal sinusitis, cold-damp stomachache, hemorrhoidal hamorrhage anal fistula, leucorrhea with red and white discharge, ulcer sores, skin pruritus due to dryness, scabies.Select Olibanum to be because its nature and flavor are arduous, temperature, enter the heart, liver, spleen channel, and regulating qi and activating blood is arranged, and analgesic therapy chases after malicious function, controls coagulation of QI-blood, trusted subordinate's pain, carbuncle pyogenic infections from tumour or sore, traumatic injury, dysmenorrhea, postnatal blood stasis twinge.Select Myrrha to be because its nature and flavor are bitter, flat, enter Liver Channel, loose blood blood stasis removing is arranged, the function of subduing swelling and relieving pain, control and fall damage, incised wound, muscles and bones, all Tong ， of trusted subordinate mass in the abdomen, amenorrhea, ulcer sore pain, anal fistula, diseases of the eye.Select Squama Manis to be because its nature and flavor are salty, cool, enter liver, stomach warp, the routed carbuncle of detumescence is arranged, search wind active, the function of the stimulating milk secretion of stimulating the menstrual flow, control the carbuncle skin ulcer swollen, anemofrigid-damp arthralgia, amenorrhea, galactostasis, external hemostasis.Select Spina Gleditsiae to be because its nature and flavor are hot, temperature, search wind, draw out pus by applying a plaster to the affected part, and detumescence, the function of evacuation of pus, control carbuncle, sore, leprosy, tinea skin ulcer, placenta retention.

The drug dose of the present invention's combination is also that the inventor draws through groping in a large number to sum up, and the consumption of each component all has good therapeutic effect in the following weight scope

Radix Angelicae Sinensis 10-20 gram Pericarpium Citri Reticulatae 10-20 gram Herba Violae 10-20 grams

Flos Lonicerae 10-20 gram Flos Jasmini Nudiflori 10-20 gram Bulbus Fritillariae Cirrhosae 8-12 grams

Radix Saposhnikoviae 8-12 gram Radix Angelicae Dahuricae 8-12 gram Olibanum 8-12 grams

Myrrha 8-12 gram Squama Manis 8-12 gram Spina Gleditsiae 8-12 grams

Preferable amount is

Radix Angelicae Sinensis 15 gram Pericarpium Citri Reticulatae 15 gram Herba Violae 15 grams

Flos Lonicerae 15 gram Flos Jasmini Nudiflori 15 gram Bulbus Fritillariae Cirrhosae 10 grams

The Radix Saposhnikoviae 10 gram Radix Angelicae Dahuricae 10 gram Olibanum 10 grams

Myrrha 10 gram Squama Manis 10 gram Spina Gleditsiae 10 grams

The preparation method of medicine of the present invention is as follows

One, get the raw materials ready

1, Radix Angelicae Sinensis: choose decontamination, clean, moistening, slightly dry in the air when suitable to inside and outside humidity, and section is dried;

2, Pericarpium Citri Reticulatae: get crude drug, remove the peel of impurity and blackening, wash quickly is clean, moistens softly, and shredding, dry or cold drying, sieve dedust bits;

3, Herba Violae: choose clean impurity, water washes away earth, and cutting is dried;

4, Flos Lonicerae: sieve removes silt, chooses clean impurity, dries;

5, Flos Jasmini Nudiflori: choose clean impurity, sieve removes silt, dries in the shade;

6, Bulbus Fritillariae Cirrhosae: choose decontamination, be soaked in water, pull out, moistening, peel off the heart, dries;

7, Radix Saposhnikoviae: remove residual stem, be soaked in water, pull out, run through section, dry;

8, the Radix Angelicae Dahuricae: choose clean impurity, wash, soak, pull out and run through, slightly shine to crust during without soapy feeling, then after moistening, chip drying;

9, Olibanum: choose the sub-impurity of shakeout;

10, Myrrha: choose decontamination, break into fragment;

11, Squama Manis: get the Squama Manis sheet of choosing clean, separately size, separately put sand in pot and fry to easily, adds the Squama Manis sheet, fries to heaving while being golden yellow, takes out, and sieve shakeout, cool;

12, Spina Gleditsiae: choose decontamination, be soaked in water, run through rear section, dry.

Two, preparation

1, the Radix Angelicae Sinensis of described weight, Pericarpium Citri Reticulatae, Herba Violae, Flos Lonicerae, Flos Jasmini Nudiflori, Bulbus Fritillariae Cirrhosae, Radix Saposhnikoviae, the Radix Angelicae Dahuricae, Olibanum, Myrrha, Squama Manis, Spina Gleditsiae medicine are decocted with water, add for the first time 5 times of amounts of water, soak after 60 minutes, intense fire decocts boiling 25 minutes, use again slow fire boiling 25 minutes, and filtered to obtain decoction liquor for the first time.

The medicinal residues that 2, will filter add 3 times of amounts of water, first boil with high heat, then use slow fire boiling 15 minutes, filter to obtain decoction liquor for the second time.

3,, with twice decoction liquor mixing and stirring, be divided into 3 doses and take.

Medicine of the present invention has clearing away heat-damp and promoting diuresis, and removing toxic substances and promoting subsidence of swelling is invigorated blood circulation, the effect of analgesic therapy, and treatment skin infection instant effect, short treating period, do not recur.

Below further set forth the beneficial effect of medicine of the present invention by test example, these tests comprise animal toxicity test report and the clinical observation material of medicine of the present invention.

The animal toxicity test report of [test example 1] medicine of the present invention

Get 40 of rabbit, the male and female dual-purpose, body weight 2.0-2.5kg, divide two groups, and 20 every group, wherein one group is the overdose test group, and another group is the normal amount test group.The super quantity group is 20ml/kg, and normal amount is 10ml/kg, and administering mode is the administration by gavage administration, every day 2 times, serve on 7 days, observe the administration reaction every day, result shows that two groups of rabbit are movable, diet is normal, medicine is without bad toxic and side effects.

The clinical observation material of [test example 2] medicine of the present invention

1, physical data

Accept out-patient's 260 examples for medical treatment.

2, diagnostic criteria

All skin infection illness all form because of the poly-blood clotting of gas, and originally local skin plays red lump or a scleroma, and the root foot is very shallow, and the scope limitation, have red and swollen heat pain, sometimes heating, xerostomia, constipation etc. can be arranged.Can be divided into stone furuncle, hidradenitis suppurativa, summer boil, furunculosis, folliculitis abscedens et suffodiens etc.

3, Therapeutic Method

Select above-mentioned medicament, to the patient, take, each serving with 1 dose, every day early, middle and late respectively the clothes 1 time, 5 days is a course for the treatment of, takes continuously 4 courses for the treatment of.

4, efficacy assessment standard

Produce effects: transference cure, the skin infection recovery from illness, it is normal that body constitution is recovered, and observes half a year without the recidivist;

Take a turn for the better: symptom is clearly better, and symptom fades away;

Invalid: as not reach improvement standard person.

5, therapeutic outcome (seeing the following form)

In above-mentioned treatment, with Drug therapy skin infection patient of the present invention 260 examples, produce effects 245 examples as a result, obvious effective rate is 94.23%, 10 examples that take a turn for the better, improvement rate is 3.85%, invalid 5 examples, total effective rate is 98.08%.

Claims

1. medicine for the treatment of skin infection, it is characterized in that: it is to be made by the crude drug in following weight range:

Myrrha 8-12 gram Squama Manis 8-12 gram Spina Gleditsiae 8-12 grams.

2. medicine according to claim 1, wherein the consumption of each crude drug is:

Myrrha 10 gram Squama Manis 10 gram Spina Gleditsiae 10 grams.

3. the preparation method of described medicine according to claim 1 and 2, it comprises the following steps:

(1) get the raw materials ready

(1) Radix Angelicae Sinensis: choose decontamination, clean, moistening, slightly dry in the air when suitable to inside and outside humidity, and section is dried;

(2) Pericarpium Citri Reticulatae: get crude drug, remove the peel of impurity and blackening, wash quickly is clean, moistens softly, and shredding, dry or cold drying, sieve dedust bits;

(3) Herba Violae: choose clean impurity, water washes away earth, and cutting is dried;

(4) Flos Lonicerae: sieve removes silt, chooses clean impurity, dries;

(5) Flos Jasmini Nudiflori: choose clean impurity, sieve removes silt, dries in the shade;

(6) Bulbus Fritillariae Cirrhosae: choose decontamination, be soaked in water, pull out, moistening, peel off the heart, dries;

(7) Radix Saposhnikoviae: remove residual stem, be soaked in water, pull out, run through section, dry;

(8) Radix Angelicae Dahuricae: choose clean impurity, wash, soak, pull out and run through, slightly shine to crust during without soapy feeling, then after moistening, chip drying;

(9) Olibanum: choose the sub-impurity of shakeout;

(10) Myrrha: choose decontamination, break into fragment;

(11) Squama Manis: get the Squama Manis sheet of choosing clean, separately size, separately put sand in pot and fry to easily, adds the Squama Manis sheet, fries to heaving while being golden yellow, takes out, and sieve shakeout, cool;

(12) Spina Gleditsiae: choose decontamination, be soaked in water, run through rear section, dry;

(2) preparation

(1) Radix Angelicae Sinensis of described weight, Pericarpium Citri Reticulatae, Herba Violae, Flos Lonicerae, Flos Jasmini Nudiflori, Bulbus Fritillariae Cirrhosae, Radix Saposhnikoviae, the Radix Angelicae Dahuricae, Olibanum, Myrrha, Squama Manis, Spina Gleditsiae medicine are decocted with water, add for the first time 5 times of amounts of water, soak after 60 minutes, intense fire decocts boiling 25 minutes, use again slow fire boiling 25 minutes, and filtered to obtain decoction liquor for the first time;

The medicinal residues that (2) will filter add 3 times of amounts of water, first boil with high heat, then use slow fire boiling 15 minutes, filter to obtain decoction liquor for the second time;

(3), with twice decoction liquor mixing and stirring, be divided into 3 doses and take.