CN102727705A - Traditional Chinese medicine composition for preventing or treating cervical erosion - Google Patents
Traditional Chinese medicine composition for preventing or treating cervical erosion Download PDFInfo
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- CN102727705A CN102727705A CN2012102517070A CN201210251707A CN102727705A CN 102727705 A CN102727705 A CN 102727705A CN 2012102517070 A CN2012102517070 A CN 2012102517070A CN 201210251707 A CN201210251707 A CN 201210251707A CN 102727705 A CN102727705 A CN 102727705A
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Abstract
The invention discloses a traditional Chinese medicine composition for preventing or treating cervical erosion and relates to the technical field of traditional Chinese medicine. The traditional Chinese medicine composition is prepared by traditional Chinese medicinal materials in parts by weight: 32-40 parts of dandelion, 32-40 parts of golden cypress, 30-35 parts of great burdock achene, 32-40 parts of lithospermum, 35-40 parts of nutgrass galingale rhizome, 35-40 parts of radix sophorae flavescentis, and 5-8 parts of borneol. The traditional Chinese medicine composition has better curative effect and quick effect in the treatment of cervical erosion with small toxic and side effects.
Description
Technical field
The present invention relates to technical field of Chinese medicines, be specifically related to the Chinese medicine composition of a kind of prevention or treatment cervical erosion.
Background technology
Cervical erosion is gynecological clinic commonly encountered diseases, frequently-occurring disease, is the one of the main reasons of bringing out cervical cancer, has a strong impact on women's physical and mental health.Cervical erosion mainly is because childbirth is miscarried, the improper mechanical damage cervix uteri that causes of puerperal infection or operation technique, and the pathogen invasion causes infection and falls ill.Treatment aspect, doctor trained in Western medicine are main with physiotherapy at present, this therapy can not eradicate pathogenic microorganism infection, can't improvement and endocrine regulation and immunopathogenesis state, and the treatment back is prone to recurrence, canceration.Chinese traditional treatment cervical erosion is with a long history, thinks this disease incidence position at born of the same parents' door, so the external treatment that adopts is made the dosage form that is easy to absorb with Chinese medicine and acted on born of the same parents' door place and carry out topical therapeutic more, effect is remarkable.
Summary of the invention
The objective of the invention is to provides a kind of better efficacy, instant effect through prescription again after the Chinese medicine pharmacology is studied, and toxic and side effects is little and can treat the Chinese medicine composition of cervical erosion.
The objective of the invention is to realize like this:
The Chinese medicine composition of a kind of prevention or treatment cervical erosion is prepared from following parts by weight of Chinese traditional medicine material: Herba Taraxaci 32-40 part, Cortex Phellodendri 32-40 part, Fructus Arctii 30-35 part, Radix Arnebiae (Radix Lithospermi) 32-40 part, Rhizoma Cyperi 35-40 part, Radix Sophorae Flavescentis 35-40 part, Borneolum Syntheticum 5-8 part.
In a preferred embodiment; The Chinese medicine composition of a kind of prevention of the present invention or treatment cervical erosion is prepared from following parts by weight of Chinese traditional medicine material: 36 parts of Herba Taraxacis, 36 parts of Cortex Phellodendris, 32 parts of Fructus Arctiis, 36 parts of Radix Arnebiae (Radix Lithospermi)s, 38 parts of Rhizoma Cyperis, 38 parts of Radix Sophorae Flavescentiss, 6 parts of Borneolum Syntheticums.
Further preferably, the Chinese medicine composition of described a kind of prevention or treatment cervical erosion is an external preparation.
Again further preferably, the Chinese medicine composition of described a kind of prevention or treatment cervical erosion is suppository, gel, ointment or liniment.
According to the record of Chinese medicine historical data, above-mentioned ten flavor Chinese medicines have following pharmacologically active:
Herba Taraxaci: have heat-clearing and toxic substances removing, dispersing swelling and dissipating binds, the effect of inducing diuresis for treating stranguria syndrome.Be used for furuncle swelling toxin, acute mastitis, scrofula, conjunctival congestion, pharyngalgia, lung abscess, acute appendicitis, jaundice due to damp-heat, the puckery pain of pyretic stranguria.Select the herb of dry Herba Taraxaci for use.
Cortex Phellodendri: heat clearing and damp drying, eliminating fire and detoxication removes the hectic fever due to YIN-deficiency clearind deficient heat.Be used for damp-heat dysentery, jaundice, leukorrhagia, pyretic stranguria, beriberi, flaccidity is warded off, hectic fever due to YIN-deficiency consumptive fever, night sweat, seminal emission, sore swollen toxin, eczema pruritus.Select the dry bark of rutaceae wampee or Cortex Phellodendri for use.
Fructus Arctii: have the effect of dispelling wind and heat pathogens, lung qi dispersing rash, sore-throat relieving eliminating stagnation, removing toxic substances and promoting subsidence of swelling, cure mainly that cough due to pathogenic wind-heat, laryngopharynx swelling and pain, macule do not pass through, rubella pruritus, sore swollen toxin.Be selected from the dry mature fruit of feverfew Fructus Arctii Arctium lappa L..
Radix Arnebiae (Radix Lithospermi): removing heat from blood, invigorate blood circulation the detoxifcation rash.Be used for that heat in blood poison is contained, purple black, the measles without adequate eruption of macule, skin infection, eczema, burn due to hot liquid or fire.Clearing away heat and cooling blood is used for measles, calentura skin eruption, eczema, hematuria, stranguria with blood, dysentery, skin infection, erysipelas, burn, constipation with heat retention.Select the root of comfrey Radix Arnebiae (Radix Lithospermi), the false Radix Arnebiae (Radix Lithospermi) in Xinjiang-Tibet or Yunnan Radix Arnebiae (Radix Lithospermi) for use.
Rhizoma Cyperi: formal name used at school Rhizoma Cyperi, the resolving depression of regulating the flow of vital energy, menstruction regulating and pain relieving.Be used for stagnation of QI due to depression of the liver, breast, the side of body, abdominal distention, dyspepsia, menoxenia, amenorrhea dysmenorrhea, colic of cold type stomachache, distending pain of the breast.
Radix Sophorae Flavescentis: heat clearing and damp drying, parasite killing, diuresis.Be used for hematodiarrhoea, have blood in stool, jaundice urine retention, leucorrhea with red and white discharge, swelling of the vulva pudendal pruritus, eczema, eczema, skin pruritus, scabies leprosy; External treatment trichomonal vaginitis.Select the root of the perennial semishrub plant's Radix Sophorae Flavescentis of falling leaves for use.
Borneolum Syntheticum: logical all keys, the stagnated fire of loosing goes nebula to make eye bright, reducing swelling and alleviating pain.Control the apoplexy locked mouth, the calentura coma, infantile convulsion expectorant fan, deafness with qi stagnation, sore throat, aphtha, otitis media, carbuncle, hemorrhoid, order is the nebula film also, enterobiasis.Select for use the resin and the volatile oil processed goods of Dipterocarpaceae plant Borneolum Syntheticum to extract the crystallization that obtains.
Above-mentioned each Chinese crude drug is prepared into the method for preparing of compound suppository of the present invention, comprises the steps:
1) get the raw materials ready: take by weighing the above-mentioned Chinese crude drug except that Borneolum Syntheticum that cleans up, subsequent use; Get the Borneolum Syntheticum of recipe quantity, be dissolved in by 1:450 (w/v) in 95% the ethanol water;
2) decoct: decocte with water, first fries in shallow oil every jar, and to add water be 8 times of medical material total amount, kept 3 hours behind the ebuillition of heated, extracting solution filters through 200 order filters and gets into settling tank; Second fries in shallow oil the water heating extraction that adds 4 times of medical material amounts, protects and boils 3 hours, and extracting solution filters through 200 order filters and gets into settling tank;
3) deposition: the extracting solution deposition is 24～36 hours in the settling tank, extracts supernatant and is filtered in the triple effect evaporator through 200 order filters, and the Borneolum Syntheticum alcoholic solution with step 1) also adds in the triple effect evaporator again;
4) concentrate: when solution is concentrated into relative density and is 1.00～1.10 (40 ℃ of mensuration) in triple effect evaporator; Rare clear paste is filtered in the suction vacuum decompressioning and concentrating tank through 200 order filters; Concentrate and be mixed to and go out cream when relative density is 1.30～1.32 (90 ℃ of mensuration); To storing in the cream bucket, subsequent use;
5) drying: vacuum :-0.1MPa wherein, temperature: 78～82 ℃, 20～24 hours drying times;
6) beat powder: smashing fineness 80 mesh sieves obtain the clear paste powder;
7) preparation suppository: take by weighing gelatin, put an amount of purified water of adding in the vessel, place about 1h, make its swelling deliquescing, add then in the rearmounted water-bath of glycerol and heat, make the gelatin dissolving, the continuation heating is also stirred; Add in the glycerin gelatine solution that has made behind qinghuo reagent powder, the Tween 80 mixing, after stirring, pour into while hot in the bolt mould of the lubricant that has coated, cooling, the part of overflowing on the die orifice of pruning, the demoulding, packing promptly gets.
The present invention finds that through the experimental study that influences to the cervical erosion rat model model group vaginal mucosa epithelitis sexual cell all occurs and invades profit, thickens.The rats in test groups inflammatory cell is invaded profit and is obviously alleviated, and the rotten to the corn area of uterine mucosa obviously reduces than XIAOMI SHUAN.This explains that Chinese medicine suppository of the present invention is remarkable to the therapeutical effect of cervical erosion rat model, is superior to prior art.In addition, show that through antiinflammatory and bacteriostatic test research Chinese medicine suppository of the present invention has the effect of antiinflammatory and vitro inhibition escherichia coli and Candida albicans, and effect all is superior to XIAOMI SHUAN.
The specific embodiment
Below be specific embodiment of the present invention, technical scheme of the present invention is further described, but protection scope of the present invention is not limited to these embodiment.Every do not deviate from the change of the present invention design or be equal to substitute include within protection scope of the present invention.
The preparation of the Chinese medicine suppository of embodiment 1 treatment cervical erosion
Crude drug prescription: 36 parts of Herba Taraxacis, 36 parts of Cortex Phellodendris, 32 parts of Fructus Arctiis, 36 parts of Radix Arnebiae (Radix Lithospermi)s, 38 parts of Rhizoma Cyperis, 38 parts of Radix Sophorae Flavescentiss, 6 parts of Borneolum Syntheticums.
Method for preparing:
1) get the raw materials ready: take by weighing the above-mentioned Chinese crude drug except that Borneolum Syntheticum that cleans up, subsequent use; Get the Borneolum Syntheticum of recipe quantity, be dissolved in by 1:450 (w/v) in 95% the ethanol water;
2) decoct: decocte with water, first fries in shallow oil every jar, and to add water be 8 times of medical material total amount, kept 3 hours behind the ebuillition of heated, extracting solution filters through 200 order filters and gets into settling tank; Second fries in shallow oil the water heating extraction that adds 4 times of medical material amounts, protects and boils 3 hours, and extracting solution filters through 200 order filters and gets into settling tank;
3) deposition: the extracting solution deposition is 24～36 hours in the settling tank, extracts supernatant and is filtered in the triple effect evaporator through 200 order filters, and the Borneolum Syntheticum alcoholic solution with step 1) also adds in the triple effect evaporator again;
4) concentrate: when solution is concentrated into relative density and is 1.05 (40 ℃ of mensuration) in triple effect evaporator; Rare clear paste is filtered in the suction vacuum decompressioning and concentrating tank through 200 order filters; Concentrate and be mixed to when relative density is 1.30～1.32 (90 ℃ of mensuration) and go out cream, to storing in the cream bucket, subsequent use;
5) drying: vacuum :-0.1MPa wherein, temperature: 78～82 ℃, 20～24 hours drying times;
6) beat powder: smashing fineness 80 mesh sieves obtain the clear paste powder;
7) preparation suppository: take by weighing the 200g gelatin, put an amount of purified water of adding in the vessel, place about 1h, make its swelling deliquescing, add then in the rearmounted water-bath of 700ml glycerol and heat, make the gelatin dissolving, the continuation heating is also stirred; Add in the glycerin gelatine solution that has made after getting 5g clear paste powder, 2ml Tween 80 mixing, after stirring, pour into while hot in the bolt mould of the lubricant that has coated, cooling, the part of overflowing on the die orifice of pruning, the demoulding, packing promptly gets.
The preparation of the Chinese medicine suppository of embodiment 2 treatment cervical erosion
Crude drug prescription: 40 parts of Herba Taraxacis, 32 parts of Cortex Phellodendris, 35 parts of Fructus Arctiis, 40 parts of Radix Arnebiae (Radix Lithospermi)s, 35 parts of Rhizoma Cyperis, 35 parts of Radix Sophorae Flavescentiss, 8 parts of Borneolum Syntheticums.
Method for preparing:
1) get the raw materials ready: take by weighing the above-mentioned Chinese crude drug except that Borneolum Syntheticum that cleans up, subsequent use; Get the Borneolum Syntheticum of recipe quantity, be dissolved in by 1:450 (w/v) in 95% the ethanol water;
2) decoct: decocte with water, first fries in shallow oil every jar, and to add water be 8 times of medical material total amount, kept 3 hours behind the ebuillition of heated, extracting solution filters through 200 order filters and gets into settling tank; Second fries in shallow oil the water heating extraction that adds 4 times of medical material amounts, protects and boils 3 hours, and extracting solution filters through 200 order filters and gets into settling tank;
3) deposition: the extracting solution deposition is 24～36 hours in the settling tank, extracts supernatant and is filtered in the triple effect evaporator through 200 order filters, and the Borneolum Syntheticum alcoholic solution with step 1) also adds in the triple effect evaporator again;
4) concentrate: when solution is concentrated into relative density and is 1.10 (40 ℃ of mensuration) in triple effect evaporator; Rare clear paste is filtered in the suction vacuum decompressioning and concentrating tank through 200 order filters; Concentrate and be mixed to when relative density is 1.30～1.32 (90 ℃ of mensuration) and go out cream, to storing in the cream bucket, subsequent use;
5) drying: vacuum :-0.1MPa wherein, temperature: 78～82 ℃, 20～24 hours drying times;
6) beat powder: smashing fineness 80 mesh sieves obtain the clear paste powder;
7) preparation suppository: take by weighing the 200g gelatin, put an amount of purified water of adding in the vessel, place about 1h, make its swelling deliquescing, add then in the rearmounted water-bath of 700ml glycerol and heat, make the gelatin dissolving, the continuation heating is also stirred; Add in the glycerin gelatine solution that has made after getting 5g clear paste powder, 2ml Tween 80 mixing, after stirring, pour into while hot in the bolt mould of the lubricant that has coated, cooling, the part of overflowing on the die orifice of pruning, the demoulding, packing promptly gets.
The preparation of the Chinese medicine suppository of embodiment 3 treatment cervical erosion
Crude drug prescription: 32 parts of Herba Taraxacis, 40 parts of Cortex Phellodendris, 30 parts of Fructus Arctiis, 32 parts of Radix Arnebiae (Radix Lithospermi)s, 40 parts of Rhizoma Cyperis, 40 parts of Radix Sophorae Flavescentiss, 6 parts of Borneolum Syntheticums.
Method for preparing:
1) get the raw materials ready: take by weighing the above-mentioned Chinese crude drug except that Borneolum Syntheticum that cleans up, subsequent use; Get the Borneolum Syntheticum of recipe quantity, be dissolved in by 1:450 (w/v) in 95% the ethanol water;
2) decoct: decocte with water, first fries in shallow oil every jar, and to add water be 8 times of medical material total amount, kept 3 hours behind the ebuillition of heated, extracting solution filters through 200 order filters and gets into settling tank; Second fries in shallow oil the water heating extraction that adds 4 times of medical material amounts, protects and boils 3 hours, and extracting solution filters through 200 order filters and gets into settling tank;
3) deposition: the extracting solution deposition is 24～36 hours in the settling tank, extracts supernatant and is filtered in the triple effect evaporator through 200 order filters, and the Borneolum Syntheticum alcoholic solution with step 1) also adds in the triple effect evaporator again;
4) concentrate: when solution is concentrated into relative density and is 1.0 (40 ℃ of mensuration) in triple effect evaporator; Rare clear paste is filtered in the suction vacuum decompressioning and concentrating tank through 200 order filters; Concentrate and be mixed to when relative density is 1.30～1.32 (90 ℃ of mensuration) and go out cream, to storing in the cream bucket, subsequent use;
5) drying: vacuum :-0.1MPa wherein, temperature: 78～82 ℃, 20～24 hours drying times;
6) beat powder: smashing fineness 80 mesh sieves obtain the clear paste powder;
7) preparation suppository: take by weighing the 200g gelatin, put an amount of purified water of adding in the vessel, place about 1h, make its swelling deliquescing, add then in the rearmounted water-bath of 700ml glycerol and heat, make the gelatin dissolving, the continuation heating is also stirred; Add in the glycerin gelatine solution that has made after getting 5g clear paste powder, 2ml Tween 80 mixing, after stirring, pour into while hot in the bolt mould of the lubricant that has coated, cooling, the part of overflowing on the die orifice of pruning, the demoulding, packing promptly gets.
Embodiment 4 Chinese medicine suppository of the present invention are to the influence of cervical erosion rat model
The preparation of blank bolt: take by weighing the 200g gelatin, put an amount of purified water of adding in the vessel, place about 1h, make its swelling deliquescing, add then in the rearmounted water-bath of 700ml glycerol and heat, make the gelatin dissolving, the continuation heating is also stirred; Add in the glycerin gelatine solution that has made after getting 2ml Tween 80 mixing, after stirring, pour into while hot in the bolt mould of the lubricant that has coated, cooling, the part of overflowing on the die orifice of pruning, the demoulding promptly gets.
48 of Healthy female rats are divided into blank group, model control group at random, positive controls, test group.Get phenol 30mL, arabic gum 40g, distilled water 50mL is made into the phenol rubber cement, advances people rat vagina with taper venotomy pin and injects phenol rubber cement 0.2mL, 1 time/3 days, totally 4 times.After the modeling success, the beginning drug treatment.Each is organized rat and is tried thing by the mode of table 1.
Table 1 grouping and administering mode
| The animal group | Sample size (only) | Receive the reagent thing |
| The blank group | 12 | Blank bolt |
| Model control group | 12 | Blank bolt |
| Positive controls | 12 | 0.3g XIAOMI SHUAN/kg |
| Test group | 12 | 0.3g middle stype (embodiment 1 preparation)/kg |
Each organizes administration 1 time/day, and successive administration 7 days was put to death animal, and got its vagina, uterus perusal and carry out histopathologic examination on the 8th day.
Dissect rat and get the uterine cancer cell perusal, model control group rat vagina, cervical tissue hyperemia, edema.The treatment group all has improvement to a certain degree.Pathologic finding, vagina and the uterine cancer cell of blank group rat are not seen obvious pathological changes, model group vaginal mucosa epithelitis sexual cell all occurs and invades profit, thickens.The rats in test groups inflammatory cell is invaded profit and is obviously alleviated, and the rotten to the corn area of uterine mucosa obviously reduces than XIAOMI SHUAN.This explains that Chinese medicine suppository of the present invention is remarkable to the therapeutical effect of cervical erosion rat model, is superior to prior art.Concrete outcome is seen table 2.
Table 2 Chinese medicine suppository of the present invention is to the pathological examination of uterine erosion rat model
In addition, show that through antiinflammatory and bacteriostatic test research Chinese medicine suppository of the present invention has the effect of antiinflammatory and vitro inhibition escherichia coli and Candida albicans, and effect all is superior to XIAOMI SHUAN.
Claims (4)
1. a Chinese medicine composition that prevents or treat cervical erosion is characterized in that being prepared from following parts by weight of Chinese traditional medicine material: Herba Taraxaci 32-40 part, Cortex Phellodendri 32-40 part, Fructus Arctii 30-35 part, Radix Arnebiae (Radix Lithospermi) 32-40 part, Rhizoma Cyperi 35-40 part, Radix Sophorae Flavescentis 35-40 part, Borneolum Syntheticum 5-8 part.
2. the Chinese medicine composition of a kind of prevention as claimed in claim 1 or treatment cervical erosion is characterized in that: be prepared from following parts by weight of Chinese traditional medicine material: 36 parts of Herba Taraxacis, 36 parts of Cortex Phellodendris, 32 parts of Fructus Arctiis, 36 parts of Radix Arnebiae (Radix Lithospermi)s, 38 parts of Rhizoma Cyperis, 38 parts of Radix Sophorae Flavescentiss, 6 parts of Borneolum Syntheticums.
3. according to claim 1 or claim 2 a kind of prevention or the Chinese medicine composition of treatment cervical erosion, it is characterized in that: said Chinese medicine composition is an external preparation.
4. according to claim 1 or claim 2 a kind of prevention or the Chinese medicine composition of treatment cervical erosion, it is characterized in that: said Chinese medicine composition is suppository, gel, ointment, liniment.
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Cited By (3)
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| CN103989792A (en) * | 2014-06-17 | 2014-08-20 | 镇江市京口朝阳中医院有限公司 | Traditional Chinese medicinal composition for treating cervical erosion, as well as preparation method and treatment device thereof |
| CN105147937A (en) * | 2015-10-15 | 2015-12-16 | 青岛云天生物技术有限公司 | Traditional Chinese medicine composition for treating ectopic cervical columnar epithelium and application thereof |
| CN105582420A (en) * | 2016-03-11 | 2016-05-18 | 济南正骐生物科技有限公司 | Suppository for treating cervical erosion |
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| CN1562142A (en) * | 2004-04-20 | 2005-01-12 | 潘星火 | Chinese medicinal gels for treating vaginitis, cervicitis and cervical erosion and its preparing method |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103989792A (en) * | 2014-06-17 | 2014-08-20 | 镇江市京口朝阳中医院有限公司 | Traditional Chinese medicinal composition for treating cervical erosion, as well as preparation method and treatment device thereof |
| CN105147937A (en) * | 2015-10-15 | 2015-12-16 | 青岛云天生物技术有限公司 | Traditional Chinese medicine composition for treating ectopic cervical columnar epithelium and application thereof |
| CN105582420A (en) * | 2016-03-11 | 2016-05-18 | 济南正骐生物科技有限公司 | Suppository for treating cervical erosion |
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Owner name: QIDONG SANJIANG CONSTRUCTION MACHINERY CO., LTD. Free format text: FORMER OWNER: CUI HEFANG Effective date: 20140728 |
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Free format text: CORRECT: ADDRESS; FROM: 266200 QINGDAO, SHANDONG PROVINCE TO: 226200 NANTONG, JIANGSU PROVINCE |
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Effective date of registration: 20140728 Address after: 226200 Nanhai Road, Binhai Industrial Park, Nantong, Jiangsu, Qidong Patentee after: Qidong Sanjiang Construction Machinery Co., Ltd. Address before: 266200 Jimo, Shandong, the Yellow River Road No. two, No. 182, No. Patentee before: Cui Hefang |