CN104474414B - A kind of medicine for treating gynaecological imflammation and preparation method thereof - Google Patents

A kind of medicine for treating gynaecological imflammation and preparation method thereof Download PDF

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CN104474414B
CN104474414B CN201410794228.2A CN201410794228A CN104474414B CN 104474414 B CN104474414 B CN 104474414B CN 201410794228 A CN201410794228 A CN 201410794228A CN 104474414 B CN104474414 B CN 104474414B
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gynaecological imflammation
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刘书华
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GUIZHOU MIAODONG BAICAO PHARMACEUTICAL DEVELOPMENT Co Ltd
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232—Angelica
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/58—Meliaceae (Chinaberry or Mahogany family), e.g. Azadirachta (neem)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/61—Myrtaceae (Myrtle family), e.g. teatree or eucalyptus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/75—Rutaceae (Rue family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/75—Rutaceae (Rue family)
    • A61K36/756—Phellodendron, e.g. corktree
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/86—Violaceae (Violet family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/904—Stemonaceae (Stemona family), e.g. croomia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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    • A61K2236/30—Extraction of the material
    • A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization

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Abstract

The invention discloses a kind of medicine for being used to treat gynaecological imflammation and preparation method thereof, the bulk pharmaceutical chemicals matched by following weight are made：0.5 2kg of frutus cnidii, 0.5 2kg of the tuber of stemona, 0.5 2kg of kuh-seng, 0.5 2kg of dittany bark, 0.5 2kg of Cortex Phellodendri, 0.5 2kg of Angelica sinensis, 0.5 2kg of azedarach, 0.005 0.1kg of alumen, 5 50ml of eucalyptus oil, 0.5 2kg of Chinese violet.By each bulk pharmaceutical chemicals by aforementioned weight proportioning materials, through over cleaning, drying, crushing, decoction, concentration and etc. to obtain the final product.Medicine of the present invention is used for the treatment of clinically gynaecological imflammation, has the characteristics that good effect, Small side effects.Clinical 156 uses, total effective rate 98.7%, and medication is convenient and efficient.

Description

A kind of medicine for treating gynaecological imflammation and preparation method thereof
Technical field
The invention belongs to the field of Chinese medicines, and in particular to a kind of medicine for treating gynaecological imflammation, also relates to the medicine Preparation method.
Background technology
Gynaecological imflammation is the common disease of women, is primarily referred to as female sex organ such as vulva, vagina etc. and is subject to various causes It is inflamed after germ infection.Inflammation often shows as vulva and pruritus of vagina, and locally generation is rotten to the corn for some, with cusalgia, odynuria, urine Frequently, vaginal fluid increase, redness etc., bring psychology, the pain of body and the inconvenience of life to patient.As treated not in time also Influence whether female reproduction.
Cause gynaecological imflammation the cause of disease include physiological disease because and the pathology cause of disease, physics can be used by treating the method for gynaecological imflammation Therapy and medicinal treatment.Being presently used for the medicine of gynaecological imflammation has very much, uses antibiosis extract for treating mostly, is frequently accompanied by easily Recurrence, the problems such as side effect is big.
In the bulk pharmaceutical chemicals that the present invention uses, frutus cnidii（Fructus Cnidii）For samphire cnidium monnieri（Cnidium monnieri（L.）Cuss）Dry mature fruit.Control eczema of vulva, married woman's pruritus vulvae, trichomonas vaginitis, eczema mange outside； Morbid leucorrhoea duye；Arthritis with fixed pain caused by dampness pain in the back；Impotence due to deficiency of the kidney；Uterus cold infertile.
The tuber of stemona（Stemona japonica）It is the plant of Stemonaceae.Root tuber can be used as medicine, toxic.Moistening lung to lower qi cough-relieving, Desinsection.Cough for new chronic cough, pulmonary tuberculosis cough, pertussis；It is used for head louse outside, body louse, enterobiasis, private parts, which is disturbed, itches.
Kuh-seng（Sophora flavescens）For pulse family kuh-seng category.Heat-clearing and damp-drying drug, desinsection, diuresis.For hot dysentery, just Blood, jaundice renal shutdown, leukorrhea with reddish discharge, swelling of vulva pruritus vulvae, eczema, wet sore, pruitus, mange leprosy；Control trichomonas vaginitis outside.
Dittany bark is cloud section herbaceos perennial dittany（Dictamnus albus L. ssp. dasycarpus (Turcz.) Wint）Skin.Wind-dispelling, eliminating dampness, heat-clearing, removing toxic substances.Cure mainly wind-heat sore, mange, itchy skin eruption, arthralgia pain due to rheumatism, Huang Subcutaneous ulcer.
Cortex Phellodendri（Cortex Phellodendri Chinensis）For rutaceae wampee or the dry tree of cork tree Skin.Cure mainly damp-heat dysentery, diarrhea, jaundice；Under nocturnal emission, stranguria with turbid discharge, band；Hectic fever due to yin labor heat, night sweat；And aphthae；Red eye, swell pain； Skin sore；Skin eczema.
Angelica sinensis（Angelica sinensis）For umbelliferae angelica（Angelica sinensis (Oliv.) Diels）Dry root.Cure mainly all cards of the deficiency of blood；Irregular menstruation；Amenorrhea；Dysmenorrhoea；Abdominal mass knot gathers；Uterine bleeding；Asthenia cold abdominalgia；Impotence numbness；Flesh Skin is numb；Intestines are dry and shit is difficult；Weight after dysentery characterized by blood in the stool；Ulcer sores；Injury from falling down.
Azedarach（Cortex meliae）For the skin of Meliaceae plant China tree, heat-clearing, eliminating dampness, desinsection.
Chinese violet（Viola philippica Car）For the whole herb with root of Violaceae Chinese violet or viola japonica.Cure mainly Traumatic injury, carbuncle swells, venomous snake bite etc. are controlled in jaundice, dysentery, mastitis, red eye, swell pain, pharyngitis external application.
Alumen also known as alum is forged, there is dissolving phlegm, eliminating dampness, antidiarrheal, stops blooding, removing toxic substances, the effect of desinsection.
Eucalyptus oil for myrtle blue gum (Eucalyptus globulus Labill), canella camphor tree (Cinnamomum camphora （L.） Sieb) or above-mentioned two section belong to the volatilization that other plant is obtained through vapor distillation together Oil.Wind-expelling pain-stopping.For pruitus.
The content of the invention
It is an object of the invention to provide a kind of good effect, the medicine of the treatment gynaecological imflammation of Small side effects.
Preparation method another object of the present invention is to the medicine for providing the treatment gynaecological imflammation.
The medicine of the present invention is prepared by the bulk pharmaceutical chemicals of following weight proportion：
0. 5-2kg of frutus cnidii, 0. 5-2kg of the tuber of stemona, 0. 5-2kg of kuh-seng, 0. 5-2kg of dittany bark, 0. 5-2kg of Cortex Phellodendri, 0. 5-2kg of Angelica sinensis, azedarach 0. 5-2kg, alumen 0.005-0.1kg, eucalyptus oil 5-50ml, 0. 5-2kg of Chinese violet.
Lotion can be made in the medicine of the present invention.
A kind of preparation method of medicine for treating gynaecological imflammation of the present invention, comprises the following steps：
（1）Bulk pharmaceutical chemicals are screened, by frutus cnidii, the tuber of stemona, kuh-seng, dittany bark, Cortex Phellodendri, Angelica sinensis, azedarach, Chinese violet is by weight Amount proportioning sampling, cleaning, drying, crush, be spare；
（2）By 0.005-0.1kg sections of moxibustions of alumen, wear into fine powder, with 60% alcohol steep 24 it is small when, filtering, filtrate is with more than Spare crushed material is uniformly mixed；
（3）Eucalyptus oil 5-50ml is added to be uniformly mixed;
（4）Add it is mixed above after 5.5-6.5 times of bulk pharmaceutical chemicals water decoct 1.5-2 it is small when, filtering, obtain filtrate；Add When the water decoction 1-1.5 of 5.5-6.5 times of the dregs of a decoction after filtering is small, filtering, obtains filtrate；
（5）Merge filtrate twice, be concentrated into 1.2 relative density, it is 60% to add 95% ethanol to adjust alcohol content, and it is small to stand 24 When, recycle ethanol, collect liquid to obtain the final product.
Compared with prior art, the present invention there is obvious beneficial effect, as can be known from the above technical solutions：The present invention selects Frutus cnidii, the tuber of stemona, kuh-seng, dittany bark, Cortex Phellodendri, Angelica sinensis, azedarach, Chinese violet, alumen, eucalyptus oil are raw material, pass through each medicine Synergistic effect treat gynaecological imflammation, can effectively antibacterial, antipruritic, desinsection, and can also rise with refrigerant effect, long-time service To gynaecology's effect of maintaining.Its expense is low, good effect, Small side effects, and medication is convenient and efficient.Clinical 156 uses, total effective rate 98.7%, obvious effective rate 89.1%.
Embodiment
Carry out the beneficial effect of the present invention is further explained the medicine below by way of test example.
Test example：The clinical observation of medicine of the present invention
Clinical data：
All cases 156, women, max age 67 years old are 19 years old minimum.
Diagnostic criteria：
《Disease of tcm Standardization of diagnosis and curative effect》
Treatment method：
Every time with liquid and warm water in proportion 1:1 hip bath 10 minutes, or directly dip in active compound with special cotton swab and be sent into a little Lesions position is put down gently, once a day, 3-5 days one course for the treatment of.
Criterion of therapeutical effect：
It is effective：Symptom disappears
Effectively：Symptom is relieved
It is invalid：Symptom is without improvement or aggravates.
Treatment results：
156 patients are through drug therapy of the present invention, effective 139, effective 15, invalid 2, total effective rate 98.7%.
Embodiment 1
A kind of medicine for treating gynaecological imflammation, comprises the following steps：
（1）Weigh frutus cnidii 0.5kg, tuber of stemona 2kg, kuh-seng 2kg, dittany bark 0.5kg, Cortex Phellodendri 0.5kg, Angelica sinensis 2kg, China tree Skin 2kg, 0. 5kg of Chinese violet cleaning, drying, crush；
（2）By 0.005kg sections of moxibustions of alumen, wear into fine powder, with 60% alcohol steep 24 it is small when, filtering, filtrate is spare with the above Crushed material is uniformly mixed；
（3）Add eucalyptus oil 50ml;
（4）Add it is mixed above after the water of 6 times of bulk pharmaceutical chemicals decoct twice, decoct for the first time 1.5 it is small when, second decocts 1 it is small when, decoct respectively filter twice；
（5）Merge filtrate twice, be concentrated into 1.2 relative density, it is 60% to add 95% ethanol to adjust alcohol content, and it is small to stand 24 When, recycle ethanol, collect liquid to obtain the final product.
Embodiment 2
A kind of medicine for treating gynaecological imflammation, comprises the following steps：
（1）Frutus cnidii 2kg, 0. 5kg of the tuber of stemona, kuh-seng 0. 5kg, dittany bark 2kg, Cortex Phellodendri 2kg, Angelica sinensis 0.5kg are weighed, it is bitter Chinaberry skin 0.5kg, Chinese violet 2kg, cleaning, drying, crush；
（2）By 0.1kg sections of moxibustions of alumen, wear into fine powder, with 60% alcohol steep 24 it is small when, filtering, filtrate and the spare powder of the above Mince uniformly mixed；
（3）Add eucalyptus oil 5ml;
（4）Add it is mixed above after the water of 5.5 times of bulk pharmaceutical chemicals decoct twice, decoct for the first time 2 it is small when, second decocts 1.5 it is small when, decoct respectively filter twice；
（5）Merge filtrate twice, be concentrated into 1.2 relative density, it is 60% to add 95% ethanol to adjust alcohol content, and it is small to stand 24 When, recycle ethanol, collect liquid to obtain the final product.
Embodiment 3
A kind of medicine for treating gynaecological imflammation, comprises the following steps：
（1）Weigh frutus cnidii 1.5kg, tuber of stemona 1.5kg, kuh-seng 1.5kg, dittany bark 1.5kg, Cortex Phellodendri 1.5kg, Angelica sinensis 1.5kg, azedarach 1.5kg, Chinese violet 1.5kg, cleaning, drying, crush；
（2）By 0.05kg sections of moxibustions of alumen, wear into fine powder, with 60% alcohol steep 24 it is small when, filtering, filtrate is spare with the above Crushed material is uniformly mixed；
（3）Add eucalyptus oil 27.5ml;
（4）Add it is mixed above after the water of 6.5 times of bulk pharmaceutical chemicals decoct twice, decoct for the first time 1.75 it is small when, second Decoct 1.25 it is small when, decoct respectively filter twice；
（5）Merge filtrate twice, be concentrated into 1.2 relative density, it is 60% to add 95% ethanol to adjust alcohol content, and it is small to stand 24 When, recycle ethanol, collect liquid to obtain the final product.

Claims (2)

1. a kind of lotion for treating gynaecological imflammation, the bulk pharmaceutical chemicals matched by following weight are made：0. 5-2kg of frutus cnidii, the tuber of stemona 0. 5-2kg, 0. 5-2kg of kuh-seng, 0. 5-2kg of dittany bark, 0. 5-2kg of Cortex Phellodendri, 0. 5-2kg of Angelica sinensis, azedarach 0. 5-2kg are withered Alum 0.005-0.1kg, eucalyptus oil 5-50ml, 0. 5-2kg of Chinese violet.
2. the preparation method of the lotion for the treatment of gynaecological imflammation as claimed in claim 1, comprises the following steps：
（1）Bulk pharmaceutical chemicals are screened, frutus cnidii, the tuber of stemona, kuh-seng, dittany bark, Cortex Phellodendri, Angelica sinensis, azedarach, Chinese violet are matched somebody with somebody by weight Than sampling, cleaning, drying, crush, be spare；
（2）Alumen 0.005-0.1kg is forged into moxibustion, wears into fine powder, with 60% alcohol steep 24 it is small when, filtering, filtrate is spare with the above Crushed material is uniformly mixed；
（3）Eucalyptus oil 5-50ml is added to be uniformly mixed；
（4）Add it is mixed above after 5.5-6.5 times of bulk pharmaceutical chemicals water decoct 1.5-2 it is small when, filtering, obtain filtrate；Add filtering When the water decoction 1-1.5 of 5.5-6.5 times of the dregs of a decoction afterwards is small, filtering, obtains filtrate；
（5）Merge filtrate twice, be concentrated into 1.2 relative density, it is 60% to add 95% ethanol to adjust alcohol content, when standing 24 is small, Recycle ethanol, collect liquid to obtain the final product.
CN201410794228.2A 2014-12-21 2014-12-21 A kind of medicine for treating gynaecological imflammation and preparation method thereof Active CN104474414B (en)

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CN105169152A (en) * 2015-08-14 2015-12-23 北京新世纪达康生物科技开发有限责任公司 Skin itch relieving washing lotion and preparation method therefor
CN105056050A (en) * 2015-08-28 2015-11-18 吉林大学 Plant extract compound suppository for treating gynecological diseases and preparation method thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020044926A1 (en) * 1999-12-10 2002-04-18 Gregor Reid Oral administration of lactobacillus for the treatment and prevention of urogenital infection
CN102000291A (en) * 2010-11-02 2011-04-06 李永胜 Liquid, powder, capsules and paste for preventing and treating gynecology

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020044926A1 (en) * 1999-12-10 2002-04-18 Gregor Reid Oral administration of lactobacillus for the treatment and prevention of urogenital infection
CN102000291A (en) * 2010-11-02 2011-04-06 李永胜 Liquid, powder, capsules and paste for preventing and treating gynecology

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