CN112138069A - Mild nano-silver antibacterial liquid - Google Patents
Mild nano-silver antibacterial liquid Download PDFInfo
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- CN112138069A CN112138069A CN202011231485.7A CN202011231485A CN112138069A CN 112138069 A CN112138069 A CN 112138069A CN 202011231485 A CN202011231485 A CN 202011231485A CN 112138069 A CN112138069 A CN 112138069A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/35—Caprifoliaceae (Honeysuckle family)
- A61K36/355—Lonicera (honeysuckle)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/38—Silver; Compounds thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/489—Sophora, e.g. necklacepod or mamani
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/51—Gentianaceae (Gentian family)
- A61K36/515—Gentiana
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/536—Prunella or Brunella (selfheal)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/86—Violaceae (Violet family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Abstract
The invention discloses a mild nano-silver antibacterial liquid, which belongs to the technical field of medical sanitation prevention and comprises the following raw materials in percentage by mass: 0.02-0.2% of a freshener, 3-8% of glycerin, 5-8% of a traditional Chinese medicine extract, 50-100 ppm of a nano silver solution and the balance of purified water. The invention uses the formula of the nano-silver antibacterial agent and the Chinese herbal medicine, overcomes the defects of irritation to mucosa and short antibacterial time caused by the traditional and existing formula technologies; meanwhile, the nano antibacterial agent in the prior art is replaced, so that the dosage is small, the antibacterial efficiency is high, and the antibacterial technical effect is sustained; the nano silver and the Chinese herbal medicine are environment-friendly, and cannot cause environmental burden; the formula is simple, the raw materials are easy to obtain, the processing procedure is simple, the operation difficulty is low, and the manufacturing cost of the antibacterial agent is reduced.
Description
Technical Field
The invention relates to a bacteriostatic solution, in particular to a mild nano-silver bacteriostatic solution, belonging to the technical field of medical sanitation prevention.
Background
The existing antibacterial agents have various types and wide application, wherein aldehyde and acid antibacterial agents have wide antibacterial spectrum, but strong corrosivity and large irritation to skin and mucosa, and chlorine-containing disinfectants have high disinfection speed and can generate a good disinfection effect at low concentration, but are easy to react with substances such as acid, alkali and the like to influence the disinfection effect, and have large irritation to the skin and the mucosa.
In the prior art, chlorine-containing disinfectants are adopted for disinfecting or cleaning human mucosa, and have the defects of high irritation, easy damage to mucosa, poor antibacterial effect and the like.
The above antibacterial agents have a common problem that the time for maintaining the antibacterial effect is short and it is difficult to form a sustained antibacterial effect, and therefore, we have further studied the antibacterial agents to develop a novel human mucosal antibacterial agent having both a good antibacterial effect and a sustained antibacterial effect.
Disclosure of Invention
The invention mainly aims to solve the defects of the prior art and provide mild nano-silver antibacterial liquid.
The purpose of the invention can be achieved by adopting the following technical scheme:
the mild nano-silver antibacterial liquid comprises the following raw materials in percentage by mass: 0.02-0.2% of a freshener, 3-8% of glycerol, 5-8% of a traditional Chinese medicine extract, 50-100 ppm of a nano silver solution and the balance of purified water;
the preparation process of the mild nano-silver antibacterial liquid is as follows:
step 1: weighing glycerol, algefacient and Chinese medicinal extract according to weight parts, and dissolving in purified water to obtain Chinese medicinal solution;
step 2: weighing the nano-silver solution according to the weight part, mixing the nano-silver solution with the traditional Chinese medicine solution obtained in the step (2), uniformly stirring, homogenizing, sieving with a 400-800-mesh sieve, sterilizing at the temperature of 75-80 ℃ for 2-3 h, and filling to obtain the finished product of the antibacterial liquid.
Preferably, the raw materials comprise the following components in percentage by mass: 0.02-0.15% of a freshener, 3-6% of glycerin, 5-6% of a traditional Chinese medicine extract, 50-100 ppm of a nano silver solution and the balance of purified water.
Preferably, the raw materials comprise the following components in percentage by mass: 0.09% of freshener, 5% of glycerin, 5% of traditional Chinese medicine extract, 50ppm of nano-silver solution and the balance of purified water.
Preferably, the cooling agents are menthol, menthyl lactate, menthyl amide and menthyl acetate.
Preferably, the Chinese herbal medicine extract is a mixture of two or more of honeysuckle extract, selfheal extract, gentian extract, Chinese violet extract or subprostrate sophora extract.
Preferably, the preparation process of the traditional Chinese medicine extract is as follows:
(1) clarifying the Chinese medicinal extractive solution, adding 0.5% chitosan, stirring for 1 hr, standing for 24 hr, and collecting supernatant;
(2) and (3) decoloring and concentrating the supernatant obtained in the step (1), and controlling the water content to be 40-45% to obtain the traditional Chinese medicine extract.
Preferably, the decoloring in (2) is performed by: adding 3% of activated carbon into the supernatant, stirring for 1-2 h, and filtering.
The invention has the beneficial technical effects that: according to the mild nano-silver antibacterial liquid, the formula of the nano-silver antibacterial agent matched with the Chinese herbal medicines is adopted, so that the defects of irritation to mucosa and short antibacterial time caused by the traditional and existing formula technologies are overcome; meanwhile, the nano antibacterial agent in the prior art is replaced, so that the dosage is small, the antibacterial efficiency is high, and the antibacterial technical effect is sustained; the nano silver and the Chinese herbal medicine are environment-friendly, and cannot cause environmental burden; the formula is simple, the raw materials are easy to obtain, the processing procedure is simple, the operation difficulty is low, and the manufacturing cost of the antibacterial agent is reduced.
Detailed Description
In order to make the technical solutions of the present invention more clear and definite for those skilled in the art, the present invention is further described in detail with reference to the following examples, but the embodiments of the present invention are not limited thereto.
The mild nano-silver antibacterial solution provided by the embodiment comprises the following raw materials in percentage by mass: 0.02-0.2% of a freshener, 3-8% of glycerol, 5-8% of a traditional Chinese medicine extract, 50-100 ppm of a nano silver solution and the balance of purified water;
the preparation process of the mild nano-silver antibacterial liquid is as follows:
step 1: weighing glycerol, algefacient and Chinese medicinal extract according to weight parts, and dissolving in purified water to obtain Chinese medicinal solution;
step 2: weighing the nano-silver solution according to the weight part, mixing the nano-silver solution with the traditional Chinese medicine solution obtained in the step (2), uniformly stirring, homogenizing, sieving with a 400-800-mesh sieve, sterilizing at the temperature of 75-80 ℃ for 2-3 h, and filling to obtain the finished product of the antibacterial liquid.
The raw materials comprise the following components in percentage by mass: 0.02-0.15% of a freshener, 3-6% of glycerin, 5-6% of a traditional Chinese medicine extract, 50-100 ppm of a nano silver solution and the balance of purified water. The raw materials comprise the following components in percentage by mass: 0.09% of freshener, 5% of glycerin, 5% of traditional Chinese medicine extract, 50ppm of nano-silver solution and the balance of purified water.
The algefacient is menthol, menthyl lactate, menthyl amide and menthyl acetate. The Chinese herbal medicine extract is two or more of flos Lonicerae extract, Prunellae Spica extract, radix Gentianae extract, herba Violae extract or radix Sophorae Tonkinensis extract.
The preparation process of the traditional Chinese medicine extract comprises the following steps:
(1) clarifying the Chinese medicinal extractive solution, adding 0.5% chitosan, stirring for 1 hr, standing for 24 hr, and collecting supernatant;
(2) and (3) decoloring and concentrating the supernatant obtained in the step (1), and controlling the water content to be 40-45% to obtain the traditional Chinese medicine extract.
The decolorization process in (2) is as follows: adding 3% of activated carbon into the supernatant, stirring for 1-2 h, and filtering.
Example 1:
the mild nano-silver antibacterial solution comprises the following raw materials in percentage by mass: 0.02% of freshener, 3% of glycerin, 5% of traditional Chinese medicine extract, 50ppm of nano-silver solution and the balance of purified water;
the preparation process of the mild nano-silver antibacterial liquid is as follows:
step 1: weighing glycerol, algefacient and Chinese medicinal extract according to weight parts, and dissolving in purified water to obtain Chinese medicinal solution;
step 2: weighing the nano-silver solution according to the weight parts, mixing the nano-silver solution with the traditional Chinese medicine solution obtained in the step (2), stirring uniformly, homogenizing, sieving with a 400-mesh sieve, sterilizing at 75 ℃ for 2 hours, and filling to obtain the finished product of the antibacterial liquid.
Example 2:
the mild nano-silver antibacterial solution comprises the following raw materials in percentage by mass: 0.06% of freshener, 4% of glycerin, 6% of traditional Chinese medicine extract, 60ppm of nano-silver solution and the balance of purified water;
the preparation process of the mild nano-silver antibacterial liquid is as follows:
step 1: weighing glycerol, algefacient and Chinese medicinal extract according to weight parts, and dissolving in purified water to obtain Chinese medicinal solution;
step 2: weighing the nano-silver solution according to the weight parts, mixing the nano-silver solution with the traditional Chinese medicine solution obtained in the step (2), stirring uniformly, homogenizing, sieving with a 400-mesh sieve, sterilizing at 75 ℃ for 2 hours, and filling to obtain the finished product of the antibacterial liquid.
Example 3:
the mild nano-silver antibacterial solution comprises the following raw materials in percentage by mass: 0.01% of freshener, 5% of glycerin, 7% of traditional Chinese medicine extract, 80ppm of nano-silver solution and the balance of purified water;
the preparation process of the mild nano-silver antibacterial liquid is as follows:
step 1: weighing glycerol, algefacient and Chinese medicinal extract according to weight parts, and dissolving in purified water to obtain Chinese medicinal solution;
step 2: weighing the nano-silver solution according to the weight parts, mixing the nano-silver solution with the traditional Chinese medicine solution obtained in the step (2), stirring uniformly, homogenizing, sieving with a 400-mesh sieve, sterilizing at 75 ℃ for 2 hours, and filling to obtain the finished product of the antibacterial liquid.
Example 4:
the mild nano-silver antibacterial solution comprises the following raw materials in percentage by mass: 0.09% of freshener, 5% of glycerin, 5% of traditional Chinese medicine extract, 50ppm of nano-silver solution and the balance of purified water;
the preparation process of the mild nano-silver antibacterial liquid is as follows:
step 1: weighing glycerol, algefacient and Chinese medicinal extract according to weight parts, and dissolving in purified water to obtain Chinese medicinal solution;
step 2: weighing the nano-silver solution according to the weight parts, mixing the nano-silver solution with the traditional Chinese medicine solution obtained in the step (2), stirring uniformly, homogenizing, sieving with a 400-mesh sieve, sterilizing at 75 ℃ for 2 hours, and filling to obtain the finished product of the antibacterial liquid.
Example 5:
the mild nano-silver antibacterial solution comprises the following raw materials in percentage by mass: 0.2% of freshener, 8% of glycerin, 8% of traditional Chinese medicine extract, 100ppm of nano-silver solution and the balance of purified water;
the preparation process of the mild nano-silver antibacterial liquid is as follows:
step 1: weighing glycerol, algefacient and Chinese medicinal extract according to weight parts, and dissolving in purified water to obtain Chinese medicinal solution;
step 2: weighing the nano-silver solution according to the weight parts, mixing the nano-silver solution with the traditional Chinese medicine solution obtained in the step (2), stirring uniformly, homogenizing, sieving with a 400-mesh sieve, sterilizing at 75 ℃ for 2 hours, and filling to obtain the finished product of the antibacterial liquid.
In summary, in this embodiment, according to the mild nano-silver antibacterial solution of this embodiment and the mild nano-silver antibacterial solution provided in this embodiment, as can be seen from embodiments 1 to 5, the mild nano-silver antibacterial solution prepared in embodiment 4 has an effect of caring mucosa, and can repair wound, effectively relieve itching, and remove odor. Adopts the mixed solution of nano-silver and Chinese herbal medicines to generate a synergistic antibacterial effect, and a small amount of freshener is added to relieve irritation; the used Chinese herbal medicines are all broad-spectrum antibacterial Chinese herbal medicines and are suitable for the special environment of human skin mucosa; the nano silver can be dissolved out again after killing bacteria, the sterilization effect is always existed, and experiments show that the nano silver can still play a sterilization role after being used for 6 hours.
The above description is only for the purpose of illustrating the present invention and is not intended to limit the scope of the present invention, and any person skilled in the art can substitute or change the technical solution of the present invention and its conception within the scope of the present invention.
Claims (7)
1. The mild nano-silver antibacterial liquid is characterized by comprising the following raw materials in percentage by mass: 0.02-0.2% of a freshener, 3-8% of glycerol, 5-8% of a traditional Chinese medicine extract, 50-100 ppm of a nano silver solution and the balance of purified water;
the preparation process of the mild nano-silver antibacterial liquid is as follows:
step 1: weighing glycerol, algefacient and Chinese medicinal extract according to weight parts, and dissolving in purified water to obtain Chinese medicinal solution;
step 2: weighing the nano-silver solution according to the weight part, mixing the nano-silver solution with the traditional Chinese medicine solution obtained in the step (2), uniformly stirring, homogenizing, sieving with a 400-800-mesh sieve, sterilizing at the temperature of 75-80 ℃ for 2-3 h, and filling to obtain the finished product of the antibacterial liquid.
2. The mild nano-silver antibacterial liquid according to claim 1, characterized in that the mild nano-silver antibacterial liquid comprises the following raw materials by mass percent: 0.02-0.15% of a freshener, 3-6% of glycerin, 5-6% of a traditional Chinese medicine extract, 50-100 ppm of a nano silver solution and the balance of purified water.
3. The mild nano-silver antibacterial liquid according to claim 1, characterized in that the mild nano-silver antibacterial liquid comprises the following raw materials by mass percent: 0.09% of freshener, 5% of glycerin, 5% of traditional Chinese medicine extract, 50ppm of nano-silver solution and the balance of purified water.
4. The mild nano-silver bacteriostatic liquid according to claim 1, wherein the cooling agents are menthol, menthyl lactate, menthyl carboxamide and menthyl acetate.
5. The mild nano-silver antibacterial solution according to claim 1, wherein the Chinese herbal medicine extract is a mixture of two or more of honeysuckle extract, selfheal extract, gentian extract, Chinese violet extract or subprostrate sophora extract.
6. The mild nano-silver bacteriostatic solution according to claim 1, wherein the preparation process of the traditional Chinese medicine extract is as follows:
(1) clarifying the Chinese medicinal extractive solution, adding 0.5% chitosan, stirring for 1 hr, standing for 24 hr, and collecting supernatant;
(2) and (3) decoloring and concentrating the supernatant obtained in the step (1), and controlling the water content to be 40-45% to obtain the traditional Chinese medicine extract.
7. The mild nanosilver bacteriostatic agent of claim 6, wherein the decoloring in (2) is as follows: adding 3% of activated carbon into the supernatant, stirring for 1-2 h, and filtering.
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| CN202011231485.7A CN112138069A (en) | 2020-11-06 | 2020-11-06 | Mild nano-silver antibacterial liquid |
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| CN202011231485.7A CN112138069A (en) | 2020-11-06 | 2020-11-06 | Mild nano-silver antibacterial liquid |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN112168863A (en) * | 2020-10-26 | 2021-01-05 | 辽宁昱众合医药科技有限公司 | Skin bacteriostatic composition and preparation method and application thereof |
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| CN112168863A (en) * | 2020-10-26 | 2021-01-05 | 辽宁昱众合医药科技有限公司 | Skin bacteriostatic composition and preparation method and application thereof |
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Application publication date: 20201229 |
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