CN108524887A - A kind of onychomycosis ointment and preparation method thereof - Google Patents

A kind of onychomycosis ointment and preparation method thereof Download PDF

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CN108524887A
CN108524887A CN201810520358.5A CN201810520358A CN108524887A CN 108524887 A CN108524887 A CN 108524887A CN 201810520358 A CN201810520358 A CN 201810520358A CN 108524887 A CN108524887 A CN 108524887A
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onychomycosis
ointment
preparation
onychomycosis ointment
acetum
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陈雨薇
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Abstract

The invention discloses a kind of onychomycosis ointment and preparation method thereof, including following preparation process：One, frutus cnidii, chaulmoogra and borneol are crushed, Chinese medicine extract I is extracted with ethanol solution；Two, aqueous extract II is made in folium artemisiae argyi and lopseed decocting and concentrating；Three, garlic and ginger are crushed into obtained concoction III of squeezing the juice；Four, Chinese medicine extract I, aqueous extract II and concoction III are mixed and is concentrated, salicylic acid and acetum is added, Traditional Chinese drug mixture IV is made；Five, honey and Traditional Chinese drug mixture IV are mixed to prepare lotion V；Six, the viscous fluid obtained after mixing vaseline and Aloe Vera Gel instills in lotion V, obtains onychomycosis ointment；Seven, ointment is high-pressure homogeneous to get finished product onychomycosis ointment.The ointment that the present invention is prepared is not required to operation and pulls out first, and need to only smear ointment can kill fungi in onychomycosis, grow new first again, and for entire healing process without any feeling of pain, healing time is short, without any side effects, no recurrence, and treatment is to patient without limitation.

Description

A kind of onychomycosis ointment and preparation method thereof
Technical field
The present invention relates to field of medicaments more particularly to a kind of onychomycosis ointment and preparation method thereof.
Background technology
Onychomycosis is commonly called as " onychomycosis ", refers to that dermatophytes invades disease caused under deck or first.Onychomycosis is often by red hair The various fungies such as tinea bacterium, alpha fungus, acrothesium floccosum cause.Minority is by other filamentous fungis, yeast-like fungus and yeast Bacterium causes, and can also be caused once in a while by pityrosporion ovale, sickle-like bacteria and ashen aspergillus etc., be more common in underfed first greatly.Clinical manifestation It is following three kinds：One, first mo(u)ld bottom half onychomycosis mostly first has slight paronychia, gradually became later often since deck both sides or end It is chronic or gradually subside.Paronychia can cause first face to have concave point or rill, continue constant or gradually involve nail root.Once deck is felt Dye, you can form crackle, become fragile or thicken, be in brown or black.This type is common.Because of keratin and detrital deposit under first, first is caused It fluffs and first is muddy plump.Two, the white first of fungoid (shallow white onychomycosis) is the one or more small muddinesses of deck surface Area, shape is irregular, can gradually involve complete deck, and first face is caused to soften, sink.Without any symptom, no paronychia is often wrinkled in nail matrix See there is furfur at folds in a garment skin.Three, the microbial onychomycosis of Candida albicans is more common in housewife, cook and often in contact with water People.It is merge paronychia more, both sides nail fold is arised from, can there is red swelling of the skin, empyema, tenderness.Neighbouring first becomes dark-coloured, raised, And the nail matrix separation under it, entire deck is involved thereafter.
And many inconvenience can be brought after suffering from onychomycosis, such as：One, it influences beautiful：It as the saying goes：" hand is the second of people Open face ", the beauty of hand directly affects the makings of a people, and the aesthetic feeling of hand, significant portion suffer from onychomycosis really in nail, hand Hinder beauty, patient and people shake hands and feel unworthy, feel awkward.Two, work is limited：The impaired consequence of nail is not only limited in It is ornamental itself, and the work that will involve or even jeopardize patient is more especially shown one's face in public and occupation that hygienic requirements is very tight, such as The work such as doctors and nurses, the catering trade, silk weaving work, public relations.Three, daily life is influenced：What the mankind were engaged in try to make a match, book It the work such as writes, cook, typewriting, weaving, playing, all be unableing to do without the assistance of nail.Once suffering from onychomycosis, this kind of work will be by dry It disturbs, nail growth has protective effect in the end of hand, once illness, hand will be easy to injured due to collision.Four, the abnormal heart is generated Manage obstacle：Onychomycosis when especially long-term treatment is invalid, usually has the poverty-stricken sense that can not be broken away from and the sense that gets a smack in the eye, especially When work, marriage, social activity fail because being influenced by onychomycosis, to the strike bigger on patients ' psychological, often therefore produce Raw inferiority complex.Five, complication is more：Onychomycosis can cause pain and discomfort, easily cause paronychia, onychia, finger pyoderma etc. simultaneously Disease is sent out, the constitutional symptom serious disease of the deep tissues such as erysipelas or cellulitis and organ infection can occur when serious, very To life threatening, feminine half, which suffers from onychomycosis, can infect private parts, and it is difficult to form colpomycosis and candida albicans vaginitis etc. With the gynaecological disease of healing.Six, become the human body infection sources：Onychomycosis readily becomes the mycotic infection sources, and patient can be with It scratches other positions of fungal infection to body, generates new tinea disease, family and friends can be also transmitted to when serious.Kith and kin are normal It is infected because changing shoes, trick contact and shared daily necessities, once it is infected, it is easy for forming tinea of feet and hands, tinea pedis and manus, erysipelas etc. Severe skin disease.
Currently, onychomycosis is most obstinate refractory one kind in dermatophytosis, first is pulled out in orally available, external used medicine, or operation. One, first is pulled out in operation：Suitable for the nail of single-shot, under local anaesthesia, first will be suffered from and pulled out, this method surface of a wound is big, bleeding, easily causes to infect. It can generally feel, compared with pain, to be easy to re-infect recurrence, clinical less use after operation.Heart disease, hypertension, diabetes Equal patients, unsuitable operative treatment.Two, endo-medicine：Suitable for multiple finger (toe) first, such as daily oral terbinafine 250mg, even It takes 6~12 weeks；Itraconazole 400mg/ days even served 7 days, rest 21 days as one therapeutic course, continue 3~6 courses for the treatment of；1~2 time weekly Fluconazole 150mg is taken, more than continuous April, 80% or more onychomycosis and onychomycosis can be cured.But because this kind of medicine must reach Competence exertion antibacterial action at the parasitic deck of fungi, dosage is big, and administration time is long, answers periodic monitoring adverse drug anti- It answers.Three, Topical therapy：According to medicament difference, main local application and package, which are cut, the methods of to be controlled.(1) use nail file (amateur Personage never uses blade, in order to avoid other diseases are infected in bleeding) by irregular bad first wear down, the mill first period is once to be preferred for 2 days； (2) 30% glacial acetic acid apply outside or the sick first of 10% glacial acetic acid bubble continues 3~6 months or more one time a day.If first by sick first before coating Skiving, curative effect is more preferably.Pay attention to being protected the skin in first week before applying first with mild ointment；(3) Terbinafine tincture, Amorolfine are selected The antimycotic externally applied drug partial smearings such as first liniment, Ciclopirox Olamine ketone first paint.
From the therapy of three of the above can be seen that operation pull out first treatment it is larger to patient's limitation, cut operation and cause The surface of a wound it is big, bleeding easily causes to infect, and postoperative pain sense is stronger, and be easy re-infect recurrence；Endo-medicine is because of dosage Larger, the duration is longer, and side effect is larger, and adverse reaction is more；Then healing time is longer for Topical therapy, if smearing ointment choosing With improper, or even without too many effect, some are curable, also can often recur.
Invention content
It is an object of the invention to overcome the deficiencies of the prior art and provide a kind of onychomycosis ointment and preparation method thereof, It is big etc. to solve the surface of a wound present in existing therapy big, bleeding, easy infection, healing time length, effect unobvious, side effect Technical problem is improved, the present invention have the characteristics that application method it is simple, it is without side-effects, quick, without recurrence.
The invention discloses following technical schemes；A kind of onychomycosis ointment, including following raw material components：Garlic, ginger, snake Machine tool, borneol, folium artemisiae argyi, chaulmoogra, lopseed, honey, salicylic acid, acetum, Aloe Vera Gel and vaseline；Wherein, each raw material The weight content of component is：
Wherein, the effect and effect of each raw material component in the formula are as follows：
Garlic, garlic are natural antibacterial plants, and the sulfide contained has stronger inhibitory or killing effect to fungi, to a variety of Coccus, bacillus, fungi and virus have killing effect, are presently found strongest one kind of natural plants antibacterial action, and grey Nail is that a certain amount of garlic is added in this side by the fungus-caused first infection such as dermatophytes, saccharomycete and non-dermatophytes, can Kill fungi.
Ginger, alias have race, Bailayun, another name for ginger, hook finger, because ground is pungent, cool kid, fresh ginger, fried ginger with honey, the rhizome of ginger (rhizoma zingiberis), cork (ginger peel), leaf (ginger leaves) can be used as medicine, because ginger has the function of significantly inhibiting dermatophyte, in this side Ginger, which is added, can more effectively kill the fungi that dermatophytes, saccharomycete and non-dermatophytes etc. cause onychomycosis.
Frutus cnidii, the Osthole contained in extract have significant antifungic action.
Borneol, mainly plays detumescence convergence wound in this side, refers to (toe) first week caused by onychomycosis for treating Side red swelling of the skin.
Folium artemisiae argyi, in addition to containing main component volatile oil, also contain tannin, flavones, alcohol, polysaccharide, trace element and other have Machine ingredient etc., these elements can demand effectively in peace-maker body, there are the works such as antibacterial, antiviral, antiallergy, enhancing immune function With onychomycosis mainly declines due to body immunity, caused by first portion is fungi-infected, folium artemisiae argyi is added in power, can have Play the role of inhibition and killing to fungi, meanwhile, the effect of multiple formulations causes patient to refer to (toe) first in ointment in order to prevent The allergy of surrounding skin, folium artemisiae argyi can play neutralization and antianaphylactic effect.
Chaulmoogra, main component are that chaulmoogric acid, hydnocarpic acid, the glycerine of dehydrogenation chaulmoogric acid are cruel, strong wind In vitro antibacterial is made for sub- olefin(e) acid, and a small amount of olein and tripalmitin etc., chaulmoogra oil and its fatty acid sodium salt With 100 times stronger than phenol or more, oily inhibiting effect is not strong, and the effect of fatty acid sodium salt is stronger, and the infusion of chaulmoogra is trying There is inhibiting effect to Microsporon audouini in pipe；Contained brown eleostearic acid has calm, spasmolysis；It is added in we big The effect of its contained chemical composition is with stronger antibiotic and sterilizing is mainly utilized in wind.
Lopseed, water decoction external application play the role of anti-inflammatory, sterilization.
Honey, sweet in flavor and neutral in nature, energy tonifying spleen moistening lung, flavoring of detoxifying are chiefly used in the drug that tonifying spleen processed moistens the lung and relieve the cough, in we The bias of drug will can be mitigated after honey and IV stirring and emulsifying of Traditional Chinese drug mixture, and synergistic effect is played with drug, heightened the effect of a treatment, To reach therapeutic purposes.
Salicylic acid and acetum have the function of killing fungi.
Aloe Vera Gel is product made of one kind is extracted with " freeze-stable method " technology from natural herbs " aloe ", Its purity is very high, has no toxic side effect, and has good anti-inflammation and sterilization, prevents inflammation allergy, bacterial growth, promotes cell newly old It is the effect of pain caused by metabolism and mitigation onychomycosis and itch, safe and reliable.
Vaseline is applied to first and covers bacterium and the contact of finger (toe) first that can be blocked in air, to reduce The possibility of persistent infection, and so that ointment is preferably infiltrated and refer to (toe) first, accelerate the repair ability of finger (toe) first itself.
Further, in order to make, each raw material component plays maximum effect in formula and effect, the above each raw material component are excellent The weight content of choosing is：
Further, to make acetum play the role of preferably killing fungi in the party, volume fraction should be 30%~45% acetum.
The invention discloses a kind of methods preparing onychomycosis ointment as above, including following preparation process：
Step 1: be positioned in beaker after weighing frutus cnidii, chaulmoogra and borneol co-grinding, with mass concentration be 60~ Soak, is then transferred in three-necked flask and is heated at reflux by 75% alcohol solution dipping 24 hours again；Filtering retains Filtrate obtains Chinese medicine extract I；
Step 2: weighing the folium artemisiae argyi after drying and lopseed is put into pot and is decocted with clear water, it is small that small fire boiling decocts 2~3 Shi Hou fishes for folium artemisiae argyi and lopseed, aqueous；Aqueous solution is simmered with small fire again, aqueous extract II is obtained after concentration；
It squeezes the juice Step 3: being put into crush in juice extractor after garlic and ginger are cleaned, after filtering, takes filtrate；It obtains Concoction III；
Step 4: the Chinese medicine extract I, aqueous extract II and concoction III are mixed, mixed liquor is obtained；Then will Mixed liquor is put into drying box and is concentrated, and concentrate is made, and salicylic acid and acetum is then added into concentrate again, stirs After mixing uniformly, Traditional Chinese drug mixture IV is obtained, it is spare；
Step 5: load weighted honey and Traditional Chinese drug mixture IV are mixed, ultrasonic, ultrasound is put into Ultrasound Instrument After obtain lotion V；
It heats while stirring Step 6: lotion V is poured into beaker；After then again mixing vaseline and Aloe Vera Gel To viscous fluid instill lotion V in, stir evenly, obtain onychomycosis ointment；
It carries out high-pressure homogeneous in high pressure homogenizer Step 7: the onychomycosis ointment is injected, is packed i.e. with aluminium skin Obtain finished product onychomycosis ointment.
Further, it in order to make the active ingredient of frutus cnidii, chaulmoogra and borneol be fully extracted use, is soaked in step 1 At 75~85 DEG C, the time of reflux is 2~3 hours for the temperature control that bubble object is heated at reflux in three-necked flask.
Further, in order to make in formula the extract containing folium artemisiae argyi and lopseed as possible, while moisture is reduced to the greatest extent Content, II volume of aqueous extract after concentrating in step 2 are 5~10ml, and density is 1.5~1.7g/ml.
Further, emulsifiable paste shape is made for the ease of the later stage, the moisture in formula components should lack as possible, in step 4 in Water content should be controlled in 5~10%wt in medicine mixture IV.
Further, in order to preferably mitigate drug after preferably promoting honey and IV stirring and emulsifying of Traditional Chinese drug mixture Bias, and play the role of cooperateing with drug and heighten the effect of a treatment, the supersonic frequency of Ultrasound Instrument is 10~15 kHz in step 5, is surpassed The sound time is 3~5 minutes.
Further, it suitably promotes temperature and mixing speed is more conducive to the mixing of lotion V, vaseline and Aloe Vera Gel, still The excessively high Cucumber ingredient that can cause in prescription of temperature is denaturalized, and therefore, the temperature heated in step 6 is controlled at 40~50 DEG C, The rate control of stirring is in 70~80r/min, and the rate control that viscous fluid is added dropwise is in 2~3d/s.
Further, onychomycosis ointment prepared according to the methods of the invention can cure institute's expense completely, by every medicine The weight of cream limits, and can reduce unnecessary drug waste, and therefore, the net weight of finished product onychomycosis ointment is 60 in step 7 ±1g。
In summary, the onychomycosis ointment being prepared by preparation method of the present invention has the advantages that：It is not required to hand Art pulls out first, without any wound, will not cause infection, and need to only smear ointment can kill fungi in onychomycosis, grows again new First, entire healing process is without any feeling of pain, it is only necessary to and external application, healing time is short, without any side effects and adverse reaction, and It smears without recurrence after ointment of the present invention is cured, treatment is to patient without limitation.
Specific implementation mode
It elaborates below to the embodiment of the present invention, the present embodiment is carried out lower based on the technical solution of the present invention Implement, gives detailed embodiment and specific operating process, but protection scope of the present invention is not limited to following implementation Example.
Embodiment 1
Embodiment 1 discloses a kind of onychomycosis ointment, including following raw material components：Garlic, ginger, frutus cnidii, borneol, Chinese mugwort Leaf, chaulmoogra, lopseed, honey, salicylic acid, acetum, Aloe Vera Gel and vaseline；
Wherein, the weight content of each raw material component is preferably：
Wherein, acetum is the acetum that volume fraction is 30%.
Present embodiment discloses a kind of methods preparing the above onychomycosis ointment, including following preparation process：
It is 60% with mass concentration Step 1: being positioned in beaker after weighing frutus cnidii, chaulmoogra and borneol co-grinding Alcohol solution dipping 24 hours, then soak is transferred in three-necked flask again and is heated at reflux, soak is at three mouthfuls At 75 DEG C, the time of reflux is 2 hours for the temperature control being heated at reflux in flask；Filtering retains filtrate, obtains Chinese medicine and carry Take liquid I；
Step 2: weighing the folium artemisiae argyi after drying and lopseed is put into pot and is decocted with clear water, small fire boiling decocts 2 hours Afterwards, folium artemisiae argyi and lopseed, aqueous are fished for；Aqueous solution is simmered with small fire again, aqueous extract II is obtained after concentration, after concentration II volume of aqueous extract be 5ml, density 1.5g/ml；
It squeezes the juice Step 3: being put into crush in juice extractor after garlic and ginger are cleaned, after filtering, takes filtrate；It obtains Concoction III；
Step 4: the Chinese medicine extract I, aqueous extract II and concoction III are mixed, mixed liquor is obtained；Then will The mixed liquor, which is put into drying box, to be concentrated, and concentrate is made, and salicylic acid then is added into concentrate again and acetic acid is molten Liquid after stirring evenly, obtains Traditional Chinese drug mixture IV, spare, and water content is 5%wt in Traditional Chinese drug mixture IV；
Step 5: load weighted honey and Traditional Chinese drug mixture IV are mixed, ultrasonic, ultrasound is put into Ultrasound Instrument After obtain lotion V, the supersonic frequency of Ultrasound Instrument is 10 kHz, and ultrasonic time is 3 minutes；
It heats while stirring Step 6: the lotion V is poured into beaker；Then vaseline and Aloe Vera Gel are mixed again The viscous fluid obtained afterwards instills in the lotion V, stirs evenly, and obtains onychomycosis ointment, the temperature of heating is 40 DEG C, is stirred The rate mixed is 70r/min, and the rate that the viscous fluid is added dropwise is 2d/s；
It carries out high-pressure homogeneous in high pressure homogenizer Step 7: the onychomycosis ointment is injected, is packed i.e. with aluminium skin Finished product onychomycosis ointment is obtained, the net weight of finished product onychomycosis ointment is 60 ± 1g.
Embodiment 2
Embodiment 2 discloses a kind of onychomycosis ointment, including following raw material components：Garlic, ginger, frutus cnidii, borneol, Chinese mugwort Leaf, chaulmoogra, lopseed, honey, salicylic acid, acetum, Aloe Vera Gel and vaseline；Wherein, the weight of each raw material component contains Amount is：
Wherein, acetum is the acetum that volume fraction is 35%.
Present embodiment discloses a kind of methods preparing the above onychomycosis ointment, including following preparation process：
It is 65% with mass concentration Step 1: being positioned in beaker after weighing frutus cnidii, chaulmoogra and borneol co-grinding Alcohol solution dipping 24 hours, then soak is transferred in three-necked flask again and is heated at reflux, soak is at three mouthfuls At 80 DEG C, the time of reflux is 2.5 hours for the temperature control being heated at reflux in flask；Filtering retains filtrate, obtains Chinese medicine Extracting solution I；
Step 2: weighing the folium artemisiae argyi after drying and lopseed is put into pot and is decocted with clear water, small fire boiling decocts 2 hours Afterwards, folium artemisiae argyi and lopseed, aqueous are fished for；Aqueous solution is simmered with small fire again, aqueous extract II is obtained after concentration, after concentration II volume of aqueous extract be 6ml, density 1.5g/ml；
It squeezes the juice Step 3: being put into crush in juice extractor after garlic and ginger are cleaned, after filtering, takes filtrate；It obtains Concoction III；
Step 4: the Chinese medicine extract I, aqueous extract II and concoction III are mixed, mixed liquor is obtained；Then will The mixed liquor, which is put into drying box, to be concentrated, and concentrate is made, and salicylic acid then is added into concentrate again and acetic acid is molten Liquid after stirring evenly, obtains Traditional Chinese drug mixture IV, spare, and water content is 6%wt in Traditional Chinese drug mixture IV；
Step 5: load weighted honey and Traditional Chinese drug mixture IV are mixed, ultrasonic, ultrasound is put into Ultrasound Instrument After obtain lotion V, the supersonic frequency of Ultrasound Instrument is 12 kHz, and ultrasonic time is 4 minutes；
It heats while stirring Step 6: the lotion V is poured into beaker；Then vaseline and Aloe Vera Gel are mixed again The viscous fluid obtained afterwards instills in the lotion V, stirs evenly, and obtains onychomycosis ointment, the temperature of heating is 45 DEG C, is stirred The rate mixed is 75r/min, and the rate that the viscous fluid is added dropwise is 2d/s；
It carries out high-pressure homogeneous in high pressure homogenizer Step 7: the onychomycosis ointment is injected, is packed i.e. with aluminium skin Finished product onychomycosis ointment is obtained, the net weight of finished product onychomycosis ointment is 60 ± 1g.
Embodiment 3
Embodiment 3 discloses a kind of onychomycosis ointment, including following raw material components：Garlic, ginger, frutus cnidii, borneol, Chinese mugwort Leaf, chaulmoogra, lopseed, honey, salicylic acid, acetum, Aloe Vera Gel and vaseline；Wherein, the weight of each raw material component contains Amount is：
Wherein, acetum is the acetum that volume fraction is 45%.
Present embodiment discloses a kind of methods preparing the above onychomycosis ointment, including following preparation process：
It is 75% with mass concentration Step 1: being positioned in beaker after weighing frutus cnidii, chaulmoogra and borneol co-grinding Alcohol solution dipping 24 hours, then soak is transferred in three-necked flask again and is heated at reflux, soak is at three mouthfuls At 85 DEG C, the time of reflux is 3 hours for the temperature control being heated at reflux in flask；Filtering retains filtrate, obtains Chinese medicine and carry Take liquid I；
Step 2: weighing the folium artemisiae argyi after drying and lopseed is put into pot and is decocted with clear water, small fire boiling decocts 3 hours Afterwards, folium artemisiae argyi and lopseed, aqueous are fished for；Aqueous solution is simmered with small fire again, aqueous extract II is obtained after concentration, after concentration II volume of aqueous extract be 10ml, density 1.7g/ml；
It squeezes the juice Step 3: being put into crush in juice extractor after garlic and ginger are cleaned, after filtering, takes filtrate；It obtains Concoction III；
Step 4: the Chinese medicine extract I, aqueous extract II and concoction III are mixed, mixed liquor is obtained；Then will The mixed liquor, which is put into drying box, to be concentrated, and concentrate is made, and salicylic acid then is added into concentrate again and acetic acid is molten Liquid after stirring evenly, obtains Traditional Chinese drug mixture IV, spare, and water content is 10%wt in Traditional Chinese drug mixture IV；
Step 5: load weighted honey and Traditional Chinese drug mixture IV are mixed, ultrasonic, ultrasound is put into Ultrasound Instrument After obtain lotion V, the supersonic frequency of Ultrasound Instrument is 15 kHz, and ultrasonic time is 5 minutes；
It heats while stirring Step 6: the lotion V is poured into beaker；Then vaseline and Aloe Vera Gel are mixed again The viscous fluid obtained afterwards instills in the lotion V, stirs evenly, and obtains onychomycosis ointment, the temperature of heating is 50 DEG C, is stirred The rate mixed is 80r/min, and the rate that the viscous fluid is added dropwise is 3d/s；
It carries out high-pressure homogeneous in high pressure homogenizer Step 7: the onychomycosis ointment is injected, is packed i.e. with aluminium skin Finished product onychomycosis ointment is obtained, the net weight of finished product onychomycosis ointment is 60 ± 1g.
Embodiment 4
Embodiment 4 discloses a kind of onychomycosis ointment, including following raw material components：Garlic, ginger, frutus cnidii, borneol, Chinese mugwort Leaf, chaulmoogra, lopseed, honey, salicylic acid, acetum, Aloe Vera Gel and vaseline；Wherein, the weight of each raw material component contains Amount is：
Wherein, acetum is the acetum that volume fraction is 40%.
Present embodiment discloses a kind of methods preparing the above onychomycosis ointment, including following preparation process：
It is 70% with mass concentration Step 1: being positioned in beaker after weighing frutus cnidii, chaulmoogra and borneol co-grinding Alcohol solution dipping 24 hours, then soak is transferred in three-necked flask again and is heated at reflux, soak is at three mouthfuls At 75 DEG C, the time of reflux is 2 hours for the temperature control being heated at reflux in flask；Filtering retains filtrate, obtains Chinese medicine and carry Take liquid I；
Step 2: weighing the folium artemisiae argyi after drying and lopseed is put into pot and is decocted with clear water, small fire boiling decocts 2 hours Afterwards, folium artemisiae argyi and lopseed, aqueous are fished for；Aqueous solution is simmered with small fire again, aqueous extract II is obtained after concentration, after concentration II volume of aqueous extract be 5ml, density 1.5g/ml；
It squeezes the juice Step 3: being put into crush in juice extractor after garlic and ginger are cleaned, after filtering, takes filtrate；It obtains Concoction III；
Step 4: the Chinese medicine extract I, aqueous extract II and concoction III are mixed, mixed liquor is obtained；Then will The mixed liquor, which is put into drying box, to be concentrated, and concentrate is made, and salicylic acid then is added into concentrate again and acetic acid is molten Liquid after stirring evenly, obtains Traditional Chinese drug mixture IV, spare, and water content is 5%wt in Traditional Chinese drug mixture IV；
Step 5: load weighted honey and Traditional Chinese drug mixture IV are mixed, ultrasonic, ultrasound is put into Ultrasound Instrument After obtain lotion V, the supersonic frequency of Ultrasound Instrument is 13 kHz, and ultrasonic time is 3 minutes；
It heats while stirring Step 6: the lotion V is poured into beaker；Then vaseline and Aloe Vera Gel are mixed again The viscous fluid obtained afterwards instills in the lotion V, stirs evenly, and obtains onychomycosis ointment, the temperature of heating is 40 DEG C, is stirred The rate mixed is 70r/min, and the rate that the viscous fluid is added dropwise is 2d/s；
It carries out high-pressure homogeneous in high pressure homogenizer Step 7: the onychomycosis ointment is injected, is packed i.e. with aluminium skin Finished product onychomycosis ointment is obtained, the net weight of finished product onychomycosis ointment is 60 ± 1g.
One, for the clinical test of onychomycosis patient.
1, subjects：250 onychomycosis patients, man 165, female 85.
2, therapy
250 onychomycosis patients are divided by treatment group's (totally four groups of Examples 1 to 4) and control using the principle of parallel control Group (totally one group), every group of 50 patients.
Through statistical analysis, each group Gender, age, the course of disease, the there was no significant difference (P such as grading>0.05), have There is comparativity.
Treatment group：After being dried within 5 minutes with warm water's immersion affected part, onychomycosis ointment produced by the present invention is smeared in affected part, 2 times a day, once in the morning and once at night.
Control group：It applies with amendment board onychomycosis antibacterial liquid, application method and the same treatment group of the frequency.
3, criterion：
(1) effective：Onychomycosis symptom disappears, and refers to (toe) first and heals completely, refers to (toe) first gloss；
(2) effectively：Cardinal symptom disappears, and refers to (toe) methyl this healing, there is slight trace；
(3) invalid：Onychomycosis symptom is not improved.
Data after contrast test are recorded, the affected part number of days used that fully recovers is fewer, rehabilitation people in same time Number more at most drug effect is better.
4, result on trial：It is shown in Table 1.
Table 1
The data recorded by table 1 are it is found that the onychomycosis ointment that the present invention is prepared applies after referring to (toe) first affected part, one In a month, the illness of patient all disappears, and refers to (toe) first and heals completely, refers to (toe) first gloss, and the ointment in control group Slowly effect, and need application healing time longer, and found in later stage long-term observation, finger (toe) first of some patients is also multiple The illness of onychomycosis is sent out.
Two, typical case：
Chen, man, 32 years old, juvenile crab was checked in crab cultivation family because that need to wear field under rubber overshoes for a long time, and foot is often airtight, hand The frequent soaking water in portion also will not greatly notice that cleaning and ventilative nursing, hand and foot refer to (toe) first and infect onychomycosis after finishing the work, Have 5 years illness histories, after smearing onychomycosis ointment produced by the present invention, one month or so refer to (toe) first be almost recovered, after by The new first grown for one month has no relapse indications rich in gloss in next year interior observation.
Lee, man, 42 years old, is engaged in agriculture, and foot is easy to perspire, and goes to work in the fields because often wearing air-locked shoes, and one busy one All day, foot do not pay attention to cleaning and ventilative, have ten years with onychomycosis, smear onychomycosis ointment produced by the present invention, and 10 It or so, onychomycosis take a favorable turn sign, refer to (toe) first within one month or so and are almost recovered, after the new first that was grown by one month it is rich Gloss has no relapse indications in next year interior observation.
Guo, man, 29 years old, cook, because long campaigns kitchen case works, hand was often soaked in water, and fungal infection causes Fingernail infections onychomycosis is had a surplus for 4 years, and after smearing the onychomycosis ointment for preparing of the present invention, two weeks or so, onychomycosis took a favorable turn mark As, refer to (toe) first within one month or so and be almost recovered, after the new first that was grown by one month rich in gloss, see in next year It examines, has no relapse indications.
Mr. Wang, 26 years old, female, common office worker, toe smeared onychomycosis ointment prepared by this product with onychomycosis 1 year, After two weeks, onychomycosis is almost recovered, and when one month, onychomycosis substantially completely restores gloss.
The onychomycosis ointment of the present invention is well-established by neighbouring group at present, is especially controlled long not with onychomycosis for many years More patient, is not required to operation and pulls out first, without any wound, will not cause infection, and only need to smear ointment can kill in onychomycosis Fungi grows new first again, and entire healing process is without any feeling of pain, it is only necessary to which external application, healing time is short, no any secondary work With and adverse reaction, and smear after ointment of the present invention is cured without recurrence, treat to patient without limitation.

Claims (10)

1. a kind of onychomycosis ointment, which is characterized in that including following raw material components：Garlic, ginger, frutus cnidii, borneol, folium artemisiae argyi, Chaulmoogra, lopseed, honey, salicylic acid, acetum, Aloe Vera Gel and vaseline；Wherein, the weight of each raw material component contains Amount is：
2. onychomycosis ointment as described in claim 1, which is characterized in that the weight content of each raw material component is：
3. onychomycosis ointment as described in claim 1, which is characterized in that the acetum be volume fraction be 30%~ 45% acetum.
4. a kind of preparation method of the onychomycosis ointment as described in claim 1-3 is any, which is characterized in that walked including following preparation Suddenly：
It is 60~75% with mass concentration Step 1: being positioned in beaker after weighing frutus cnidii, chaulmoogra and borneol co-grinding Alcohol solution dipping 24 hours, then soak is transferred in three-necked flask again and is heated at reflux；Filtering retains filter Liquid obtains Chinese medicine extract I；
Step 2: weigh the folium artemisiae argyi after drying and lopseed is put into pot and is decocted with clear water, after small fire boiling decocts 2~3 hours, Fish for folium artemisiae argyi and lopseed, aqueous；Aqueous solution is simmered with small fire again, aqueous extract II is obtained after concentration；
It squeezes the juice Step 3: being put into crush in juice extractor after garlic and ginger are cleaned, after filtering, takes filtrate；Obtain concoction Ⅲ；
Step 4: the Chinese medicine extract I, aqueous extract II and concoction III are mixed, mixed liquor is obtained；It then will be described Mixed liquor is put into drying box and is concentrated, and concentrate is made, and salicylic acid and acetum is then added into concentrate again, stirs After mixing uniformly, Traditional Chinese drug mixture IV is obtained, it is spare；
Step 5: load weighted honey and Traditional Chinese drug mixture IV are mixed, it is put into ultrasound in Ultrasound Instrument, after ultrasound To lotion V；
It heats while stirring Step 6: the lotion V is poured into beaker；After then again mixing vaseline and Aloe Vera Gel To viscous fluid instill in the lotion V, stir evenly, obtain onychomycosis ointment；
Step 7: the onychomycosis ointment is injected in high pressure homogenizer carry out it is high-pressure homogeneous, with aluminium skin pack up at Product onychomycosis ointment.
5. the preparation method of onychomycosis ointment as claimed in claim 4, which is characterized in that soak is in three-necked flask in step 1 At 75~85 DEG C, the time of reflux is 2~3 hours for the middle temperature control being heated at reflux.
6. the preparation method of onychomycosis ointment as claimed in claim 4, which is characterized in that the aqueous extract after being concentrated in step 2 II volume is 5~10ml, and density is 1.5~1.7g/ml.
7. the preparation method of onychomycosis ointment as claimed in claim 4, which is characterized in that Traditional Chinese drug mixture IV described in step 4 Middle water content is 5~10%wt.
8. the preparation method of onychomycosis ointment as claimed in claim 4, which is characterized in that the supersonic frequency of Ultrasound Instrument in step 5 For 10~15 kHz, ultrasonic time is 3~5 minutes.
9. the preparation method of onychomycosis ointment as claimed in claim 4, which is characterized in that the temperature heated in step 6 be 40~ 50 DEG C, the rate of stirring is 70~80r/min, and the rate that the viscous fluid is added dropwise is 2~3d/s.
10. the preparation method of onychomycosis ointment as claimed in claim 4, which is characterized in that finished product onychomycosis described in step 7 The net weight of ointment is 60 ± 1g.
CN201810520358.5A 2018-05-28 2018-05-28 A kind of onychomycosis ointment and preparation method thereof Withdrawn CN108524887A (en)

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108355125A (en) * 2018-05-28 2018-08-03 陈雨薇 Anti- chap ointment of one kind and preparation method thereof
CN108355042A (en) * 2018-05-28 2018-08-03 陈雨薇 A kind of anti-inflammatory analgetic ointment and preparation method thereof
CN112717076A (en) * 2021-03-17 2021-04-30 湖南翰坤实业有限公司 Ointment for treating onychomycosis and preparation method thereof

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103394001A (en) * 2013-07-03 2013-11-20 袁娟 Specific medicine for curing beriberi and preparation method thereof
CN104173873A (en) * 2014-09-04 2014-12-03 胡健 External ointment for treating onychomycosis
CN105056052A (en) * 2015-09-08 2015-11-18 李治国 Externally applied traditional Chinese medicine composition for treating tinea pedis
CN105963599A (en) * 2016-06-01 2016-09-28 范影 Externally-applied ointment for treating onychomycosis of feet
CN105998971A (en) * 2016-06-01 2016-10-12 范影 Preparation method for traditional Chinese medicine lotion used for treating onychomycosis
CN106902225A (en) * 2015-12-18 2017-06-30 李中利 A kind of Chinese medicine preparation for treating onychomycosis
CN107158293A (en) * 2017-05-05 2017-09-15 王维维 Treat Chinese medicine composition of onychomycosis and preparation method thereof
CN107582937A (en) * 2017-10-20 2018-01-16 王兴波 A kind of beriberi liquor for effectively improving therapeutic effect and preparation method thereof

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103394001A (en) * 2013-07-03 2013-11-20 袁娟 Specific medicine for curing beriberi and preparation method thereof
CN104173873A (en) * 2014-09-04 2014-12-03 胡健 External ointment for treating onychomycosis
CN105056052A (en) * 2015-09-08 2015-11-18 李治国 Externally applied traditional Chinese medicine composition for treating tinea pedis
CN106902225A (en) * 2015-12-18 2017-06-30 李中利 A kind of Chinese medicine preparation for treating onychomycosis
CN105963599A (en) * 2016-06-01 2016-09-28 范影 Externally-applied ointment for treating onychomycosis of feet
CN105998971A (en) * 2016-06-01 2016-10-12 范影 Preparation method for traditional Chinese medicine lotion used for treating onychomycosis
CN107158293A (en) * 2017-05-05 2017-09-15 王维维 Treat Chinese medicine composition of onychomycosis and preparation method thereof
CN107582937A (en) * 2017-10-20 2018-01-16 王兴波 A kind of beriberi liquor for effectively improving therapeutic effect and preparation method thereof

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
国家中医药管理局专业技术资格考试专家委员会: "《全国中医药专业技术资格考试大纲与细则》", 30 November 2016, 中国中医药出版社 *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108355125A (en) * 2018-05-28 2018-08-03 陈雨薇 Anti- chap ointment of one kind and preparation method thereof
CN108355042A (en) * 2018-05-28 2018-08-03 陈雨薇 A kind of anti-inflammatory analgetic ointment and preparation method thereof
CN112717076A (en) * 2021-03-17 2021-04-30 湖南翰坤实业有限公司 Ointment for treating onychomycosis and preparation method thereof

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