CN108355125A - Anti- chap ointment of one kind and preparation method thereof - Google Patents
Anti- chap ointment of one kind and preparation method thereof Download PDFInfo
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- CN108355125A CN108355125A CN201810520232.8A CN201810520232A CN108355125A CN 108355125 A CN108355125 A CN 108355125A CN 201810520232 A CN201810520232 A CN 201810520232A CN 108355125 A CN108355125 A CN 108355125A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/738—Rosa (rose)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/82—Theaceae (Tea family), e.g. camellia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/886—Aloeaceae (Aloe family), e.g. aloe vera
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/898—Orchidaceae (Orchid family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9068—Zingiber, e.g. garden ginger
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
Abstract
The invention discloses a kind of anti-chap ointment and preparation method thereof：1) by ginseng, Radix Angelicae Sinensis, ginger and bletilla striata co-grinding, alcohol solution dipping is heated at reflux；Filtering retains filtrate, obtains Chinese medical extract I；2) it weighs fresh phoenix tree leaf to decoct, obtains Chinese parasol tree leaf extract II；3) Chinese medical extract I, Chinese parasol tree leaf extract II, Aloe Vera Gel and titanium dioxide are put into beaker, are stirred evenly, obtain sticky mixture III；4) essential oil and tea oil are mixed, obtain mixed liquor IV；5) mixed liquor IV, dispersant and vaseline are poured into sticky mixture III, is stirred evenly, obtain ointment crude product；6) ointment crude product is high-pressure homogeneous, anti-chap ointment is made.The anti-Chap cream being prepared by the present invention can prevent to chap and cure fatiscent symptom of having chapped, and this side is without side-effects, it remains able to smear in the case where chap has breach bleeding and use, it can play the role of anti-inflammatory analgetic healing of wound, and this side is quick, healing time is short.
Description
Technical field
The present invention relates to field of medicaments, more particularly to a kind of anti-chap ointment and preparation method thereof.
Background technology
Chap is mainly in brothers, generally in autumn and winter.Fash is distributed in finger and bends side, palm, heel, isogonism on the outside of vola pedis
The position that matter layer is thickened or often rubbed against, clinical manifestation are the depth developed along dermatoglyph, crack different in size, and skin lesion can be from nothing
It is any to feel slight shouting pain or moderate tenderness or even cusalgia and with bleeding.
Chap is fallen ill interior because cuticula is thicker, special thick at positions such as palm plantars, is easily cracked, is slapped plantar without hair follicle and skin
Adipose gland, when temperature is low smaller with humidity in winter, the skin for lacking sebum protection is just easy to happen cracking；In addition the elderly, fish
Situations such as squama disease and seborrheic keratosis, easily causes dry skin, and cuticula more thickens, and is more easy to send out under the influence of some extraneous factors
Disease.It is outer to be often exposed to outside because of brothers, often in contact with various external substances, cause the drying, friction, wound of brothers, in this way
So that hand-foot skin surface layer is susceptible to acid, alkali, organic solvent fat melting effect and the intrusion such as fungi, bacterium and causes to infect,
In life, labour, if paying no heed to and maintaining, the drawing of activities so that brothers' Yi Fasheng chapped skins.If this disease
It protects proper, can fully recover in winter；Once cracking is formed, cure relatively difficult.
Currently there are anti-Chap cream, be only capable of playing the effect for preventing rhagadia manus et pedis, for the hand chapped
Skin of foot is generally difficult to cure, if in the case that skin has chapped and had breach bleeding, anti-Chap cream cannot be applied to
It, otherwise can tingle on wound.Meanwhile in order to which the moisture of possessing for keeping brothers lasting prevents drying, most of anti-chap
It is bigger to split cream oiliness, after smearing, it appears very greasy.
Invention content
It is an object of the invention to overcome the deficiencies of the prior art and provide a kind of anti-chap ointment and preparation method thereof,
It is only capable of playing prevention effect to solve existing anti-Chap cream, the skin chapped can not be cured, cannot directly be applied to
It chaps and has on the wound of breach bleeding and excessively greasy etc. technical problems of lotion are improved, the present invention has can be pre-
Anti- chap, and fatiscent symptom of having chapped can be cured, and this side is without side-effects, still in the case where chap has breach bleeding
Use can be smeared, anti-inflammatory analgetic healing of wound can be played the role of, and this side is quick, it is short the time required to curing.
The invention discloses following technical schemes；A kind of anti-chap ointment, including following raw material components：Ginseng, Radix Angelicae Sinensis, life
Ginger, the bletilla striata, Aloe Vera Gel, phoenix tree leaf, titanium dioxide, essential oil, dispersant, tea oil and vaseline；Wherein, the weight group of each raw material component
Part it is：
Wherein, each raw material component plays following effect in invention formula：
Ginseng is known as King of Herbs, and many-sided effect has obtained more and more confirmations, for skin,
Ginseng can be promoted blood circulation, prevent skin ageing and wrinkle from generating, increase the nutrition supply of skin because being rich in panaxoside,
Immune function can also be improved simultaneously, prevents destructive stimulus of the skin by external environment, human metabolism, deep layer can be accelerated to grow
Moisten skin, prevents dry and aging, and effectively treatment itch and decortication, keep face skin moist, make skin pure white tender.
Ginseng is added in this side, can promote blood circulation, increases the nutrition supply of skin, promotes the reparation of skin at chap.
Radix Angelicae Sinensis, containing inorganic in 17 kinds of amino acid and 23 necessary to abundant vitamin A, E, B12, volatile oil and human body
Element.The extracting solution of Radix Angelicae Sinensis can inhibit the activity of TYR enzyme, and TYR enzyme can make skin generate freckle, blackspot, age spot
Melanin, scar after breach or wound healing can be prevented by the lotion of chapped skin healing angelica extract being added.
Ginger has the ingredients such as gingerol, lauro lene in contained volatile oil, can stimulate skin, keeps telangiectasis congested,
It promotes blood circulation, to early stage, the skin of chap has good therapeutic effect.
The bletilla striata is the stem tuber of the orchid family herbaceos perennial bletilla striata, is ancient simply astringing to arrest bleeding Chinese medicine, to later stage chap
It splits or skin that breach is bled has effects that astringing to arrest bleeding.
Aloe Vera Gel, aloe water moisten exquisitely carved pulp and are rich in the abundant moisturizing moisturizing factor, and external application can allow skin water tender ten
Foot, and the effect of aloe and effect compares and releives, it is suitble to sensitivity skin；And Aloe Vera Gel be one kind with " freeze-stable method " skill
Art product made of extraction from the natural herbs " aloe ", purity is very high, has no toxic side effect, it to incised wound, scratch,
The wound operative scar etc. that festers has an apparent booster action, also has a good anti-inflammation and sterilization beauty functions, it is safe to use can
It leans on.Aloe Vera Gel is added in we may make lotion to be applicable in any kind of skin, and sensitive skin has been avoided to smear because inadaptable
And there is red and swollen uncomfortable symptom, and Aloe Vera Gel moistening effect is good, and dry skin can be made to restore water profit, to cure at chap
Skin.
Phoenix tree leaf, usually because the dry and cold appearance of weather is red and swollen, phoenix tree leaf is added in this side to be played the skin at chap
The effect of removing toxicity for detumescence.
Titanium dioxide, using nanometer titanium dioxide in the present invention, with uvioresistant, antibacterial, self-cleaning, anti-aging
The effect of.
Essential oil has effects that conditioning skin Secretion, can adjust hormone and purify skin, mildly repair skin,
And essential oil has effects that anti-inflammation and sterilization.
Dispersant, be it is a kind of in the molecule while there is the interfacial agents of two kinds of opposite natures of lipophile and hydrophily,
In this side be added dispersant can make well each raw material component mix it is finer and smoother, avoid the occurrence of mixing it is excessively sticky,
Lotion smears irregular phenomenon.
Tea oil, containing vitamin E and antioxidant content, therefore it can protect skin, can especially prevent skin injury and decline
Always, make skin that there is gloss.
Vaseline, smearing can keep skin wet on the skin, and the skin histology of wound location is made to keep optimum state,
The bacterium in air and skin contact are blocked, to reduce the possibility of infection, accelerates the reparation of skin itself
Ability.
Further, the optimal parts by weight of raw material components are：
Further, in order to preferably make essential oil play conditioning skin Secretion the effect of, the function of skin is repaired, essence
Oil selects Rosa Damascana with tea tree ethereal oil according to mass ratio 2:1 progress mixture is made, wherein Rosa Damascana, be referred to as " essential oil it
Afterwards ", improve dry skin, restore skin elasticity, skin is allowed to restore pale, full of elasticity；Tea tree ethereal oil originates in Australia, is tea
The extract of tree has bactericidal antiphlogistic, convergence pore and other effects, can treat suppurative wound and burn, tan severely, be added in this side
Tea tree ethereal oil can effectively treat the skin of chap opening bleeding.
Further, dispersant has makes the finer and smoother of each raw material component mixing well, avoids the occurrence of mixing excessively
Sticky, lotion smears irregular phenomenon, but in order to not have irritation after so that the lotion after being formed is smeared, to the harmless of human body
Property, dispersant selects polyvinylpyrrolidone, polyvinylpyrrolidone to have excellent physiological inertia, is not involved in human body new old generation
It thanks, and there is excellent biocompatibility, any stimulation is not formed to skin, mucous membrane, eye etc..
A method of preparing anti-chap ointment in the present invention, including following preparation process：
1) ginseng, Radix Angelicae Sinensis, ginger and the bletilla striata are weighed and carries out co-grinding, is poured the mixture into after crushing and uses matter in beaker
Measure a concentration of 75~80% alcohol solution dipping 24 hours, then mixture is transferred in three-necked flask again carry out reflux plus
Heat；Filtering retains filtrate, and Chinese medical extract I is obtained after evaporating solvent；
2) it weighs fresh phoenix tree leaf and is put into pot after being cleaned and decocted with water, after small fire boiling decocts 2~3 hours,
Phoenix tree leaf is fished for, Chinese parasol tree leaf extract II will be obtained after boiling liquid concentration；
3) Chinese medical extract I and Chinese parasol tree leaf extract II are put into beaker and are merged, and be added and weigh into beaker
Aloe Vera Gel and titanium dioxide, stir evenly under 35 DEG C of heating water baths, obtain sticky mixture III, keep the temperature, it is spare；
4) essential oil and tea oil are mixed, are put into incubator after miscible and carry out Heat preservation, obtains mixed liquor
Ⅳ；
5) mixed liquor IV after heat preservation is poured into spare sticky mixture III, and is added into sticky mixture III
Dispersant and vaseline after stirring evenly, obtain ointment crude product；
6) the ointment crude product is injected in high pressure homogenizer carry out it is high-pressure homogeneous, to get to anti-chap after aluminium suitcase dress
Ointment.
Further, in order to make the lotion uniform and smooth being prepared, by ginseng, Radix Angelicae Sinensis, ginger and the bletilla striata in step 1)
It is put into pulverizer and crushes, and mixture is ground into 80~120 mesh powder particles.
Further, in order to make the Chinese medical extract being prepared I not contain solvent, ingredient is purer, in step 1)
The temperature being heated at reflux is controlled at 85~90 DEG C；Evaporation solvent carries out the filtrate to vacuumize heating using Rotary Evaporators
Mode is handled.
Further, in order to make essential oil the effect of, performs to ultimate attainment, and essential oil and other raw material components can be made more preferable
Fusion, the temperature in step 4) in incubator controls at 50~55 DEG C.
Anti- chap ointment of one kind disclosed by the invention and preparation method thereof, has the advantages that：The anti-chap ointment
It can promote blood circulation, increase the nutrition supply of skin, promote the reparation of skin at chap；After can preventing breach or wound healing
Scar；To early stage, the skin of chap has good therapeutic effect, and the skin bled to later stage chap or breach has convergence
The effect of hemostasis；It is applicable in any kind of skin, sensitive skin is avoided to smear the symptom for occurring red and swollen discomfort because inadaptable,
And Aloe Vera Gel moistening effect is good, dry skin can be made to restore water profit, to cure the skin at chap；The effect of removing toxicity for detumescence
Fruit；Skin injury and aging can be prevented, makes skin that there is gloss；Anti- Chap cream made from preparation method according to the invention, respectively
Raw material components mixing it is finer and smoother, avoid the occurrence of mixing it is excessively sticky, lotion smears irregular phenomenon；Make the skin of wound location
Skin tissue keeps optimum state, blocks the bacterium in air and skin contact, to reduce the possibility of infection, adds
The speed repair ability of skin itself.
Specific implementation mode
It elaborates below to the embodiment of the present invention, the present embodiment is carried out lower based on the technical solution of the present invention
Implement, gives detailed embodiment and specific operating process, but protection scope of the present invention is not limited to following implementation
Example.
Embodiment 1
Embodiment 1 discloses a kind of anti-chap ointment, including following raw material components：Ginseng, Radix Angelicae Sinensis, ginger, the bletilla striata, aloe
Glue, phoenix tree leaf, titanium dioxide, essential oil, dispersant, tea oil and vaseline；Wherein, the composition by weight of each raw material component is：
Wherein, essential oil selects Rosa Damascana with tea tree ethereal oil according to mass ratio 2:1 progress mixture is made.
Wherein, dispersant selects polyvinylpyrrolidone.
A method of preparing anti-chap ointment in the present invention, including following preparation process：
1) ginseng, Radix Angelicae Sinensis, ginger and the bletilla striata are weighed and carries out co-grinding, mixture is ground into 120 mesh powder particles,
The alcohol solution dipping 24 hours for being 80% with mass concentration in beaker is poured the mixture into after crushing, then again turns mixture
It moves on in three-necked flask and is heated at reflux, the temperature being heated at reflux is controlled at 90 DEG C；Filtering retains filtrate, after evaporating solvent
Obtain Chinese medical extract I, evaporation solvent is handled in such a way that Rotary Evaporators carry out filtrate vacuumizing heating；
2) it weighs fresh phoenix tree leaf and is put into pot after being cleaned and decocted with tap water, after small fire boiling decocts 3 hours,
Phoenix tree leaf is fished for, Chinese parasol tree leaf extract II is obtained after concentration；
3) Chinese medical extract I and Chinese parasol tree leaf extract II are put into beaker and are merged, and be added and claim into the beaker
Measured Aloe Vera Gel and titanium dioxide stir evenly under 35 DEG C of heating water baths, obtain sticky mixture III, keep the temperature, spare；
4) essential oil and tea oil are mixed, are put into incubator after miscible and carry out Heat preservation, in incubator
Temperature is controlled at 55 DEG C, obtains mixed liquor IV；
5) mixed liquor IV after heat preservation is poured into spare sticky mixture III, and is added into sticky mixture III
Dispersant and vaseline after stirring evenly, obtain ointment crude product；
6) the ointment crude product is injected in high pressure homogenizer carry out it is high-pressure homogeneous, to get to anti-chap after aluminium suitcase dress
Ointment.
Embodiment 2
Embodiment 2 discloses a kind of anti-chap ointment, including following raw material components：Ginseng, Radix Angelicae Sinensis, ginger, the bletilla striata, aloe
Glue, phoenix tree leaf, titanium dioxide, essential oil, dispersant, tea oil and vaseline；Wherein, the composition by weight of each raw material component is：
Wherein, essential oil selects Rosa Damascana with tea tree ethereal oil according to mass ratio 2:1 progress mixture is made.
Wherein, dispersant selects polyvinylpyrrolidone.
A method of preparing anti-chap ointment in the present invention, including following preparation process：
1) ginseng, Radix Angelicae Sinensis, ginger and the bletilla striata are weighed and carries out co-grinding, mixture is ground into 80 mesh powder particles,
The alcohol solution dipping 24 hours for being 75% with mass concentration in beaker is poured the mixture into after crushing, then again turns mixture
It moves on in three-necked flask and is heated at reflux, the temperature being heated at reflux is controlled at 85 DEG C；Filtering retains filtrate, after evaporating solvent
Obtain Chinese medical extract I, evaporation solvent is handled in such a way that Rotary Evaporators carry out filtrate vacuumizing heating；
2) it weighs fresh phoenix tree leaf and is put into pot after being cleaned and decocted with clear water, after small fire boiling decocts 2 hours, fishing
Phoenix tree leaf is taken, Chinese parasol tree leaf extract II is obtained after concentration；
3) Chinese medical extract I and Chinese parasol tree leaf extract II are put into beaker and are merged, and be added and claim into the beaker
Measured Aloe Vera Gel and titanium dioxide stir evenly under 35 DEG C of heating water baths, obtain sticky mixture III, keep the temperature, spare；
4) essential oil and tea oil are mixed, are put into incubator after miscible and carry out Heat preservation, in incubator
Temperature is controlled at 50 DEG C, obtains mixed liquor IV；
5) mixed liquor IV after heat preservation is poured into spare sticky mixture III, and is added into sticky mixture III
Dispersant and vaseline after stirring evenly, obtain ointment crude product；
6) the ointment crude product is injected in high pressure homogenizer carry out it is high-pressure homogeneous, to get to anti-chap after aluminium suitcase dress
Ointment.
Embodiment 3
Embodiment 3 discloses a kind of anti-chap ointment, including following raw material components：Ginseng, Radix Angelicae Sinensis, ginger, the bletilla striata, aloe
Glue, phoenix tree leaf, titanium dioxide, essential oil, dispersant, tea oil and vaseline；Wherein, the composition by weight of each raw material component is：
Wherein, essential oil selects Rosa Damascana with tea tree ethereal oil according to mass ratio 2:1 progress mixture is made.
Wherein, dispersant selects polyvinylpyrrolidone.
A method of preparing anti-chap ointment in the present invention, including following preparation process：
1) ginseng, Radix Angelicae Sinensis, ginger and the bletilla striata are weighed and carries out co-grinding, mixture is ground into 120 mesh powder particles,
The alcohol solution dipping 24 hours for being 75~80% with mass concentration in beaker is poured the mixture into after crushing, it then again will mixing
Object is transferred in three-necked flask and is heated at reflux, and the temperature being heated at reflux is controlled at 90 DEG C；Filtering, retains filtrate, and evaporation is molten
Obtain Chinese medical extract I after agent, evaporation solvent is handled in such a way that Rotary Evaporators carry out filtrate vacuumizing heating；
2) it weighs fresh phoenix tree leaf and is put into pot after being cleaned and decocted, after small fire boiling decocts 3 hours, fish for Chinese parasol tree
Leaf obtains Chinese parasol tree leaf extract II after concentration；
3) Chinese medical extract I and Chinese parasol tree leaf extract II are put into beaker and are merged, and be added and claim into the beaker
Measured Aloe Vera Gel and titanium dioxide stir evenly under 35 DEG C of heating water baths, obtain sticky mixture III, keep the temperature, spare；
4) essential oil and tea oil are mixed, are put into incubator after miscible and carry out Heat preservation, in incubator
Temperature is controlled at 55 DEG C, obtains mixed liquor IV；
5) mixed liquor IV after heat preservation is poured into spare sticky mixture III, and is added into sticky mixture III
Dispersant and vaseline after stirring evenly, obtain ointment crude product；
6) the ointment crude product is injected in high pressure homogenizer carry out it is high-pressure homogeneous, to get to anti-chap after aluminium suitcase dress
Ointment.
Embodiment 4
Embodiment 4 discloses a kind of anti-chap ointment, including following raw material components：Ginseng, Radix Angelicae Sinensis, ginger, the bletilla striata, aloe
Glue, phoenix tree leaf, titanium dioxide, essential oil, dispersant, tea oil and vaseline；Wherein, the composition by weight of each raw material component is：
Wherein, essential oil selects Rosa Damascana with tea tree ethereal oil according to mass ratio 2:1 progress mixture is made.
Wherein, dispersant selects polyvinylpyrrolidone.
A method of preparing anti-chap ointment in the present invention, including following preparation process：
1) ginseng, Radix Angelicae Sinensis, ginger and the bletilla striata are weighed and carries out co-grinding, mixture is ground into 100 mesh powder particles,
The alcohol solution dipping 24 hours for being 75~80% with mass concentration in beaker is poured the mixture into after crushing, it then again will mixing
Object is transferred in three-necked flask and is heated at reflux, and the temperature being heated at reflux is controlled at 87 DEG C；Filtering, retains filtrate, and evaporation is molten
Obtain Chinese medical extract I after agent, evaporation solvent is handled in such a way that Rotary Evaporators carry out filtrate vacuumizing heating；
2) it weighs fresh phoenix tree leaf and is put into pot after being cleaned and decocted, after small fire boiling decocts 2.5 hours, fish for Chinese parasol tree
Paulownia leaf obtains Chinese parasol tree leaf extract II after concentration；
3) Chinese medical extract I and Chinese parasol tree leaf extract II are put into beaker and are merged, and be added and claim into the beaker
Measured Aloe Vera Gel and titanium dioxide stir evenly under 35 DEG C of heating water baths, obtain sticky mixture III, keep the temperature, spare；
4) essential oil and tea oil are mixed, are put into incubator after miscible and carry out Heat preservation, in incubator
Temperature is controlled at 53 DEG C, obtains mixed liquor IV；
5) mixed liquor IV after heat preservation is poured into spare sticky mixture III, and is added into sticky mixture III
Dispersant and vaseline after stirring evenly, obtain ointment crude product；
6) the ointment crude product is injected in high pressure homogenizer carry out it is high-pressure homogeneous, to get to anti-chap after aluminium suitcase dress
Ointment.
One, for the clinical test of rhagadia manus et pedis patient.
1, subjects：250 rhagadia manus et pedis patients, man 165, female 85.
2, therapy
250 rhagadia manus et pedis patients are divided by treatment group's (totally four groups of Examples 1 to 4) and right using the principle of parallel control
According to group (totally one group), every group of 50 patients.
Through statistical analysis, each group Gender, age, the course of disease, the there was no significant difference (P such as grading>0.05), have
There is comparativity.
Treatment group：After being dried within 5 minutes with warm water's immersion affected part, anti-chap ointment produced by the present invention is smeared in affected part,
2 times a day, once in the morning and once at night.
Control group：Painting peace pacifies be chapped from the cold cream, application method and the same treatment group of the frequency.
3, criterion：
(1) effective：Symptom disappears at rhagadia manus et pedis, and skin heals completely, no scar；
(2) effectively：Cardinal symptom disappears, and heals substantially at skin chap, there is slight trace；
(3) invalid：Rhagadia manus et pedis symptom is not improved.
Data after contrast test are recorded, the affected part number of days used that fully recovers is fewer, rehabilitation people in same time
Number more at most drug effect is better.
4, result on trial：It is shown in Table 1.
Table 1
The data recorded by table 1 in two weeks, are suffered from it is found that behind the anti-chap ointment coating affected part that the present invention is prepared
The illness of person all disappears, and skin heals completely at chap, and the ointment slowly effect in control group, and needs application healing time
It is longer, and found in later stage long-term observation, the same affected part of some patients is also reoccurred the illness of the rhagadia manus et pedis.
Two, typical case：
Zhang, women, 35 years old, Anhui Province Fuyang City people, government functionary need to often go out, and belong to drying type skin, exist throughout the year
Autumn and winter moistens brothers' skin with rhagadia manus et pedis, because can usually smear some face cream, and not especially severe, smears this hair
After bright anti-chap ointment, heal completely at 5 days i.e. chap, skin restores elasticity, without any trace.
45 years old, nurse's work is done in urban district by Mrs Li, people from Nanling County, because managing labor service for a long time and not maintained, hand
Foot chap it is more serious, in winter, especially hand when be often accompanied by the phenomenon that breach is bled, smear the present invention anti-chap ointment after, 2
It or so heals at cracking of bleeding, after two weeks, heals completely at hand chap substantially, no sharp trace.
Guo, man, mould factory service worker, 29 years old, stature was sturdy, because often with the raw and cold coarse object such as mold steel
Come into contacts with, hand be chapped from the cold it is coarse, but it is not opening bleed, smear the present invention anti-chap ointment after, be cured completely at chap in 5 days
It closes, skin restores as before, without any trace.
Mr. Wang, 13 years old, student often helped household to manage household affairs, in addition itself belonging to drying type skin because of family financial situation difficulty
Skin is not nursed again usually, and hand, which is chapped from the cold, bleeds seriously, smears anti-chap ointment of the invention after two weeks, basic at chap
Restore as before, skin trace unobvious.
The anti-chap ointment of the present invention is well-established by neighbouring group at present, can promote blood circulation after smearing, increases
The nutrition supply of skin promotes the reparation of skin at chap；It can prevent scar after breach or wound healing；It chaps to early stage
Skin have good therapeutic effect, have effects that astringing to arrest bleeding to later stage chap or the skin bled of breach；It is applicable in any
The skin of type avoids sensitive skin from smearing the symptom for occurring red and swollen discomfort because inadaptable, and Aloe Vera Gel moistening effect is good,
Dry skin can be made to restore water profit, to cure the skin at chap；The effect of removing toxicity for detumescence；It can prevent skin injury and decline
Always, make skin that there is gloss；Anti- Chap cream made from preparation method according to the invention, the more refinement of each raw material component mixing
It is greasy, avoid the occurrence of mixing it is excessively sticky, lotion smears irregular phenomenon；The skin histology of wound location is set to keep optimum state,
The bacterium in air and skin contact are blocked, to reduce the possibility of infection, accelerates the reparation of skin itself
Ability.Especially in dry autumn and winter, which can both use usually as hand lotion, can also prevent brothers
Chap, pernio.
Claims (8)
1. a kind of anti-chap ointment, which is characterized in that including following raw material components：Ginseng, Radix Angelicae Sinensis, ginger, the bletilla striata, Aloe Vera Gel,
Phoenix tree leaf, titanium dioxide, essential oil, dispersant, tea oil and vaseline；Wherein, the composition by weight of each raw material component is：
2. anti-chap ointment as described in claim 1, which is characterized in that the parts by weight of the raw material components are：
3. anti-chap ointment as described in claim 1, which is characterized in that the essential oil be Rosa Damascana with tea tree ethereal oil according to
Mass ratio 2:1 progress mixture is made.
4. anti-chap ointment as described in claim 1, which is characterized in that the dispersant is polyvinylpyrrolidone.
5. a kind of preparation method of chap ointment anti-as described in claim 1-4 is any, which is characterized in that walked including following preparation
Suddenly：
1) ginseng, Radix Angelicae Sinensis, ginger and the bletilla striata are weighed and carries out co-grinding, is poured the mixture into after crushing dense with quality in beaker
Mixture, is then transferred in three-necked flask and is heated at reflux by the alcohol solution dipping that degree is 75~80% 24 hours again；
Filtering retains filtrate, and Chinese medical extract I is obtained after evaporating solvent；
2) it weighs fresh phoenix tree leaf and is put into pot after being cleaned and decocted with water, after small fire boiling decocts 2~3 hours, fished for
Phoenix tree leaf will obtain Chinese parasol tree leaf extract II after boiling liquid concentration；
3) Chinese medical extract I and Chinese parasol tree leaf extract II are put into beaker and are merged, and be added and weigh into the beaker
Aloe Vera Gel and titanium dioxide, stir evenly under 35 DEG C of heating water baths, obtain sticky mixture III, keep the temperature, it is spare；
4) essential oil and tea oil are mixed, are put into incubator after miscible and carry out Heat preservation, obtain mixed liquor IV；
5) mixed liquor IV after heat preservation is poured into spare sticky mixture III, and is added into the sticky mixture III
Dispersant and vaseline after stirring evenly, obtain ointment crude product；
6) the ointment crude product is injected in high pressure homogenizer carry out it is high-pressure homogeneous, to get to anti-chap ointment after aluminium suitcase dress.
6. the preparation method of anti-chap ointment as claimed in claim 5, which is characterized in that by ginseng, Radix Angelicae Sinensis, ginger in step 1)
It is put into pulverizer and crushes with the bletilla striata, and mixture is ground into 80~120 mesh powder particles.
7. the preparation method of anti-chap ointment as claimed in claim 5, which is characterized in that the temperature control being heated at reflux in step 1)
System is at 85~90 DEG C；Evaporation solvent is handled in such a way that Rotary Evaporators carry out the filtrate vacuumizing heating.
8. the preparation method of anti-chap ointment as claimed in claim 5, which is characterized in that the temperature in incubator described in step 4)
Degree control is at 50~55 DEG C.
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