CN108371674A - It is a kind of to be used to treat ointment of verruca vulgaris and preparation method thereof - Google Patents
It is a kind of to be used to treat ointment of verruca vulgaris and preparation method thereof Download PDFInfo
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- CN108371674A CN108371674A CN201810520219.2A CN201810520219A CN108371674A CN 108371674 A CN108371674 A CN 108371674A CN 201810520219 A CN201810520219 A CN 201810520219A CN 108371674 A CN108371674 A CN 108371674A
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- 239000003814 drug Substances 0.000 claims abstract description 23
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 21
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Classifications
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/04—Sulfur, selenium or tellurium; Compounds thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/22—Boron compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
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- A61K35/63—Arthropods
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
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- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/12—Keratolytics, e.g. wart or anti-corn preparations
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Abstract
The invention discloses a kind of ointment and preparation method thereof for treating verruca vulgaris, which is characterized in that including following preparation process：1) cicada slough and Radix Glycyrrhizae are weighed, extracting solution A is prepared with absolute ethyl alcohol；2) it weighs peppermint young leaves and anhydrous ethanol solvent is added, obtain extracting solution B；3) Herba Schizonepetae volatile oil is prepared with schizonepeta；4) sesame flower extracting solution is made with fresh sesame flower；5) Chinese parasol tree leaf extract is made with fresh phoenix tree leaf；6) after extracting solution A, extracting solution B, sesame flower extracting solution and Chinese parasol tree leaf extract being sloughed solvent, itself and Herba Schizonepetae volatile oil are stirred, obtain medicament crude product D；7) by glycerin monostearate and sulphur emulsifiable paste together with medicament crude product D heating stirring, form white paste；8) white paste is carried out high-pressure homogeneous to get to target ointment.Verruca vulgaris ointment prepared by the present invention has the healing period short, can effect a radical cure, not recur, and without side-effects, preparation method is simple, and cost of material is low, is suitable for promoting and produce in batches.
Description
Technical field
The present invention relates to field of medicaments, and in particular to a kind of for treating ointment of verruca vulgaris and preparation method thereof.
Background technology
Verruca vulgaris is one kind in wart disease, claims " wart mesh ", " verruca vulgaris " " withered muscle arrow " in China's medicine, is commonly called as " thorn
Wart ", " wart " etc..It is apt to occur in teenager, is more common in dorsal digital, foot edge etc..The damage of skin and mucous membrane is to cause to infect
The main reason for initial stage show as firmly solid small papule, in sallow or yellowish-brown etc., rough surface angling.This disease is by mankind's breast
Head tumor virus (HPV) is caused, and by direct or indirect contagion, wound is a critically important factor to HPV infection.Institute
Not to be that self-blood is ill caused by long wart is virus infection.But the generation of this disease is related with immune status, exempts from
Epidemic disease defect state person, as the incidence of kidney transplant, malignant lymphoma, chronic lymphatic leukemia and lupus erythematosus patient's wart increases
It is high.Lesion initial stage can increase to several or dozens of and differ from the beginning of mostly 1 later.It can increase in spot with disease progression skin lesion
Sheet.
The treatment of verruca vulgaris is divided into drug therapy and physiotherapy two major classes.Physiotherapy mainly has：Liquid nitrogen frozen, laser
Burn, excision etc. of performing the operation can also cause body secondary injury because recurrence rate is very high, therefore it is not recommended that using.Currently on the market
The Chinese medicine of the treatment verruca vulgaris of sale, after use, verruca vulgaris can also recur, and can not be effected a radical cure, and topical application of drug period when use
Can just it be made to fall off up to 2~3 months.However the use of Western medicine, and certain side effect can be generated to human body.Currently on the market
The production preparation process of the Chinese and Western medicine of existing treatment verruca vulgaris is more complicated, and cost of material is higher.By preparation side of the invention
The verruca vulgaris ointment healing period made from method is as short as 1~2 week, can effect a radical cure, will not recur again after application, and to human body without any pair
Effect, the preparation method of the ointment is relatively easy in terms of process for producing, and cost of material price is relatively low, be suitable for promote and
Batch production.
Invention content
It is an object of the invention to solve currently there are treatment verruca vulgaris Chinese and Western medicine, production preparation process is multiple
It is miscellaneous, cost of material price height is prepared, and after patient's application, the healing period is long, is not easy to effect a radical cure, and some pairs can be generated to human body and made
The technical issues of using.In order to solve the above technical problems, the following technical solutions are proposed by the present invention：
The present invention provides a kind of ointment for treating verruca vulgaris, including the following raw material component：Cicada slough, Radix Glycyrrhizae, peppermint,
Schizonepeta, sesame flower, phoenix tree leaf, glycerin monostearate and sulphur emulsifiable paste.
Wherein, cicada slough is sweet in flavor, salty, cool in nature, dispelling wind-heat, promoting eruption relieving sore-throat, removing nebula for improving eyesight, expelling wind and relieving convulsion.
Radix Glycyrrhizae is mild-natured, sweet, is the Chinese medicine of tonifying Qi benefit spleen simply, and Radix Glycyrrhizae also has the function of clearing heat and detoxicating, diuresis promoting,
Radix Glycyrrhizae energy emergency, moreover it is possible to play the role of the reconciliation to all medicines.
Peppermint acrid flavour, it is cool in nature, there is wind-dispelling heat-dissipating, refresh oneself, throat, promoting eruption, effect of Xie Yu.
Schizonepeta taste is flat, and warm-natured, nontoxic, faint scent is dense, can town phlegm, wind-dispelling, cool blood.
Sesame flower flat property and sweet taste has the effect of hair tonic, detumescence, can hair growth, pernio, constipation etc., in civil folk prescription
Common sesame flower treatment verruca vulgaris, flat wart etc., verruca vulgaris, the illness of flat wart make moderate progress after applying for a long time, but effect a radical cure
It is ineffective.
Phoenix tree leaf bitter, it is cold in nature, there is the effect of dispelling wind and eliminating dampness, removing toxicity for detumescence, blood pressure lowering.It is usually used in controlling for ulcerative carbuncle pyogenic infections
It treats.
Glycerin monostearate is the emulsifier and additive of food, is used as emulsifier in cosmetics and medical paste, can
Keep lotion fine and smooth, it is lubricious.
Sulphur emulsifiable paste is one Chinese medicinal formulae, and main component has sublimed sulfur, borax, emulsifiable paste matrix etc., is usually used in scabies, head
In the treating for skin disease such as tinea, psoriasis, acne and seborrhea.
Further, raw material components preferably play medicinal efficacy, the weight of each raw material component in the ointment to make the present invention
Measuring number is：
Further, raw material components play maximum medicinal efficacy, the weight of each raw material component in the ointment to make the present invention
Measuring number is preferably：
The present invention provides a kind of preparation methods for treating verruca vulgaris ointment, including following preparation process：
1) cicada slough and Radix Glycyrrhizae after drying are weighed, and the two is ground crushing, three mouthfuls are poured the mixture into after crushing
In flask, absolute ethyl alcohol is used in combination to be heated at reflux mixture；Then phegma is filtered while hot, retains filtrate, system
Obtain extracting solution A；
2) weigh peppermint young leaves and cleaned drying after be put into beaker and into the beaker be added absolute ethyl alcohol it is molten
Agent, 50~60 DEG C of heating water baths are after 24 hours, after taking out peppermint blade, retain extracting solution, obtain extracting solution B；
3) it weighs after schizonepeta crushes and is put into the three-necked flask for being contained with deionized water, stirring distillation centrifuges distillate
Processing, stands after centrifugation, takes upper layer fluid to get Herba Schizonepetae volatile oil, spare；
4) the fresh sesame flower weighed is ground crushing with mortar, and solidliquid mixture after grinding is taken out with funnel
Filter retains filtrate；Then filtrate is poured into separatory funnel, makees extracting solution with ethyl acetate；Organic layer is extracted, sesame flower is obtained
Extracting solution；
5) the fresh phoenix tree leaf weighed is ground crushing with mortar, and solidliquid mixture after grinding is filtered, protected
Reserved filtrate；Then filtrate is poured into separatory funnel, makees extracting solution with ethyl acetate；Organic layer is extracted, phoenix tree leaf extraction is obtained
Liquid；
6) the extracting solution A obtained, extracting solution B, sesame flower extracting solution and Chinese parasol tree leaf extract are merged, is steamed with rotation
After hair instrument progress vacuum is spin-dried for solvent, mixed extract C is obtained；And the mixed extract C is stirred with the Herba Schizonepetae volatile oil
After mixing mixing, medicament crude product D is obtained；
7) by glycerin monostearate and sulphur emulsifiable paste according to mass ratio 5:1 carries out proportioning mixing, while by medicament obtained
Crude product D is stirred together, and carries out Heat preservation, forms white paste；
8) it will be carried out in the white paste injection high pressure homogenizer high-pressure homogeneous to get to target ointment.
Further, in order to keep absolute ethyl alcohol extraction cicada slough and Radix Glycyrrhizae beneficiating ingredient more thorough, nothing is used in step 1)
The temperature that water-ethanol is heated at reflux mixture is controlled at 80~85 DEG C, and the temperature being filtered while hot to phegma is not low
In 50 DEG C.
Further, the excessive volatilization of the Herba Schizonepetae volatile oil that extracts in order to prevent influences drug effect, schizonepeta described in step 3)
Volatile oil needs to be positioned over shady and cool closed place's storage.
Further, the dissolvent residual for each extracting solution being mixed in mixed extract C in order to prevent influences ointment drug effect, needs
The dissolvent residual being wherein mixed with all is removed, extracts the extracting solution A obtained, extracting solution B, sesame flower in step 6)
Liquid and Chinese parasol tree leaf extract are merged with beaker, and 3A type molecular sieves are added into the beaker and are stirred, and stirring 24 is small
Shi Hou, then carry out vacuum with Rotary Evaporators and be spin-dried for solvent.
Further, in order to make the grinding of fresh sesame flower more thoroughly, increase utilization rate, to having weighed in step 4)
During fresh sesame flower is ground with mortar, 5~8g quartz sands can be added in the mortar as grinding agent.
In summary, the beneficial effects of the present invention are the ointment for the treatment of verruca vulgaris prepared by the invention, which has, cures week
Phase is as short as 1~2 week, can be effected a radical cure after application, will not recur again, and without any side effects to human body, in terms of process for producing
The preparation method of the ointment is relatively easy, and cost of material price is relatively low, is suitable for promoting and produce in batches.
Specific implementation mode
It elaborates below to the embodiment of the present invention, the present embodiment is carried out lower based on the technical solution of the present invention
Implement, gives detailed embodiment and specific operating process, but protection scope of the present invention is not limited to following implementation
Example.
Embodiment 1
Embodiment 1 discloses a kind of ointment for treating verruca vulgaris, which is characterized in that as follows including raw material components：Cicada
Slough off, Radix Glycyrrhizae, peppermint, schizonepeta, sesame flower, phoenix tree leaf, glycerin monostearate and sulphur emulsifiable paste.Wherein, the parts by weight of raw material components
Number is：
A method of it is prepared with the above raw material components ratio for treating verruca vulgaris ointment, including following preparation process：
1) cicada slough and Radix Glycyrrhizae after drying are weighed, and the two is ground crushing, three mouthfuls are poured the mixture into after crushing
In flask, absolute ethyl alcohol is used in combination to be heated at reflux mixture；Then phegma is filtered while hot, retains filtrate, system
Obtain extracting solution A；
2) weigh peppermint young leaves and cleaned drying after be put into beaker and into the beaker be added absolute ethyl alcohol it is molten
Agent, 50~60 DEG C of heating water baths are after 24 hours, after taking out peppermint blade, retain extracting solution, obtain extracting solution B；
3) it weighs after schizonepeta crushes and is put into the three-necked flask for being contained with deionized water, stirring distillation centrifuges distillate
Processing, stands after centrifugation, takes upper layer fluid to get Herba Schizonepetae volatile oil, spare；
4) the fresh sesame flower weighed is ground crushing with mortar, and solidliquid mixture after grinding is taken out with funnel
Filter retains filtrate；Then filtrate is poured into separatory funnel, makees extracting solution with ethyl acetate；Organic layer is extracted, sesame flower is obtained
Extracting solution；
5) the fresh phoenix tree leaf weighed is ground crushing with mortar, and solidliquid mixture after grinding is filtered, protected
Reserved filtrate；Then filtrate is poured into separatory funnel, makees extracting solution with ethyl acetate；Organic layer is extracted, phoenix tree leaf extraction is obtained
Liquid；
6) the extracting solution A obtained, extracting solution B, sesame flower extracting solution and Chinese parasol tree leaf extract are merged, is steamed with rotation
After hair instrument progress vacuum is spin-dried for solvent, mixed extract C is obtained；And the mixed extract C is stirred with the Herba Schizonepetae volatile oil
After mixing mixing, medicament crude product D is obtained；
7) by glycerin monostearate and sulphur emulsifiable paste according to mass ratio 5:1 carries out proportioning mixing, while by medicament obtained
Crude product D is stirred together, and carries out Heat preservation, forms white paste；
8) it will be carried out in the white paste injection high pressure homogenizer high-pressure homogeneous to get to target ointment.
Wherein, the temperature being heated at reflux to mixture with absolute ethyl alcohol in step 1) is controlled at 80~85 DEG C, while hot
50 DEG C are not less than to the temperature that phegma is filtered.
Wherein, Herba Schizonepetae volatile oil described in step 3) needs to be positioned over shady and cool closed place's storage.
Wherein, the extracting solution A obtained, extracting solution B, sesame flower extracting solution and Chinese parasol tree leaf extract are used in step 6)
Beaker merges, and 3A type molecular sieves are added into the beaker and are stirred, and after stirring 24 hours, then uses Rotary Evaporators
It carries out vacuum and is spin-dried for solvent.
It wherein, can in the mortar during being ground with mortar to the fresh sesame flower weighed in step 4)
5~8g quartz sands are added as grinding agent.
Embodiment 2
Embodiment 2 discloses a kind of ointment for treating verruca vulgaris, which is characterized in that as follows including raw material components：Cicada
Slough off, Radix Glycyrrhizae, peppermint, schizonepeta, sesame flower, phoenix tree leaf, glycerin monostearate and sulphur emulsifiable paste.Wherein, the parts by weight of raw material components
Number is：
A method of it is prepared with the above raw material components ratio for treating verruca vulgaris ointment, including following preparation process：
1) cicada slough and Radix Glycyrrhizae after drying are weighed, and the two is ground crushing, three mouthfuls are poured the mixture into after crushing
In flask, absolute ethyl alcohol is used in combination to be heated at reflux mixture；Then phegma is filtered while hot, retains filtrate, system
Obtain extracting solution A；
2) weigh peppermint young leaves and cleaned drying after be put into beaker and into the beaker be added absolute ethyl alcohol it is molten
Agent, 50~60 DEG C of heating water baths are after 24 hours, after taking out peppermint blade, retain extracting solution, obtain extracting solution B；
3) it weighs after schizonepeta crushes and is put into the three-necked flask for being contained with deionized water, stirring distillation centrifuges distillate
Processing, stands after centrifugation, takes upper layer fluid to get Herba Schizonepetae volatile oil, spare；
4) the fresh sesame flower weighed is ground crushing with mortar, and solidliquid mixture after grinding is taken out with funnel
Filter retains filtrate；Then filtrate is poured into separatory funnel, makees extracting solution with ethyl acetate；Organic layer is extracted, sesame flower is obtained
Extracting solution；
5) the fresh phoenix tree leaf weighed is ground crushing with mortar, and solidliquid mixture after grinding is filtered, protected
Reserved filtrate；Then filtrate is poured into separatory funnel, makees extracting solution with ethyl acetate；Organic layer is extracted, phoenix tree leaf extraction is obtained
Liquid；
6) the extracting solution A obtained, extracting solution B, sesame flower extracting solution and Chinese parasol tree leaf extract are merged, is steamed with rotation
After hair instrument progress vacuum is spin-dried for solvent, mixed extract C is obtained；And the mixed extract C is stirred with the Herba Schizonepetae volatile oil
After mixing mixing, medicament crude product D is obtained；
7) by glycerin monostearate and sulphur emulsifiable paste according to mass ratio 5:1 carries out proportioning mixing, while by medicament obtained
Crude product D is stirred together, and carries out Heat preservation, forms white paste；
8) it will be carried out in the white paste injection high pressure homogenizer high-pressure homogeneous to get to target ointment.
Wherein, the temperature being heated at reflux to mixture with absolute ethyl alcohol in step 1) is controlled at 80~85 DEG C, while hot
50 DEG C are not less than to the temperature that phegma is filtered.
Wherein, Herba Schizonepetae volatile oil described in step 3) needs to be positioned over shady and cool closed place's storage.
Wherein, the extracting solution A obtained, extracting solution B, sesame flower extracting solution and Chinese parasol tree leaf extract are used in step 6)
Beaker merges, and 3A type molecular sieves are added into the beaker and are stirred, and after stirring 24 hours, then uses Rotary Evaporators
It carries out vacuum and is spin-dried for solvent.
It wherein, can in the mortar during being ground with mortar to the fresh sesame flower weighed in step 4)
5~8g quartz sands are added as grinding agent.
Embodiment 3
Embodiment 3 discloses a kind of ointment for treating verruca vulgaris, which is characterized in that as follows including raw material components：Cicada
Slough off, Radix Glycyrrhizae, peppermint, schizonepeta, sesame flower, phoenix tree leaf, glycerin monostearate and sulphur emulsifiable paste.Wherein, the parts by weight of raw material components
Number is：
A method of it is prepared with the above raw material components ratio for treating verruca vulgaris ointment, including following preparation process：
1) cicada slough and Radix Glycyrrhizae after drying are weighed, and the two is ground crushing, three mouthfuls are poured the mixture into after crushing
In flask, absolute ethyl alcohol is used in combination to be heated at reflux mixture；Then phegma is filtered while hot, retains filtrate, system
Obtain extracting solution A；
2) weigh peppermint young leaves and cleaned drying after be put into beaker and into the beaker be added absolute ethyl alcohol it is molten
Agent, 50~60 DEG C of heating water baths are after 24 hours, after taking out peppermint blade, retain extracting solution, obtain extracting solution B；
3) it weighs after schizonepeta crushes and is put into the three-necked flask for being contained with deionized water, stirring distillation centrifuges distillate
Processing, stands after centrifugation, takes upper layer fluid to get Herba Schizonepetae volatile oil, spare；
4) the fresh sesame flower weighed is ground crushing with mortar, and solidliquid mixture after grinding is taken out with funnel
Filter retains filtrate；Then filtrate is poured into separatory funnel, makees extracting solution with ethyl acetate；Organic layer is extracted, sesame flower is obtained
Extracting solution；
5) the fresh phoenix tree leaf weighed is ground crushing with mortar, and solidliquid mixture after grinding is filtered, protected
Reserved filtrate；Then filtrate is poured into separatory funnel, makees extracting solution with ethyl acetate；Organic layer is extracted, phoenix tree leaf extraction is obtained
Liquid；
6) the extracting solution A obtained, extracting solution B, sesame flower extracting solution and Chinese parasol tree leaf extract are merged, is steamed with rotation
After hair instrument progress vacuum is spin-dried for solvent, mixed extract C is obtained；And the mixed extract C is stirred with the Herba Schizonepetae volatile oil
After mixing mixing, medicament crude product D is obtained；
7) by glycerin monostearate and sulphur emulsifiable paste according to mass ratio 5:1 carries out proportioning mixing, while by medicament obtained
Crude product D is stirred together, and carries out Heat preservation, forms white paste；
8) it will be carried out in the white paste injection high pressure homogenizer high-pressure homogeneous to get to target ointment.
Wherein, the temperature being heated at reflux to mixture with absolute ethyl alcohol in step 1) is controlled at 80~85 DEG C, while hot
50 DEG C are not less than to the temperature that phegma is filtered.
Wherein, Herba Schizonepetae volatile oil described in step 3) needs to be positioned over shady and cool closed place's storage.
Wherein, the extracting solution A obtained, extracting solution B, sesame flower extracting solution and Chinese parasol tree leaf extract are used in step 6)
Beaker merges, and 3A type molecular sieves are added into the beaker and are stirred, and after stirring 24 hours, then uses Rotary Evaporators
It carries out vacuum and is spin-dried for solvent.
It wherein, can in the mortar during being ground with mortar to the fresh sesame flower weighed in step 4)
5~8g quartz sands are added as grinding agent.
Embodiment 4
Embodiment 4 discloses a kind of ointment for treating verruca vulgaris, which is characterized in that as follows including raw material components：Cicada
Slough off, Radix Glycyrrhizae, peppermint, schizonepeta, sesame flower, phoenix tree leaf, glycerin monostearate and sulphur emulsifiable paste.Wherein, the parts by weight of raw material components
Number is：
A method of it is prepared with the above raw material components ratio for treating verruca vulgaris ointment, including following preparation process：
1) cicada slough and Radix Glycyrrhizae after drying are weighed, and the two is ground crushing, three mouthfuls are poured the mixture into after crushing
In flask, absolute ethyl alcohol is used in combination to be heated at reflux mixture；Then phegma is filtered while hot, retains filtrate, system
Obtain extracting solution A；
2) weigh peppermint young leaves and cleaned drying after be put into beaker and into the beaker be added absolute ethyl alcohol it is molten
Agent, 50~60 DEG C of heating water baths are after 24 hours, after taking out peppermint blade, retain extracting solution, obtain extracting solution B；
3) it weighs after schizonepeta crushes and is put into the three-necked flask for being contained with deionized water, stirring distillation centrifuges distillate
Processing, stands after centrifugation, takes upper layer fluid to get Herba Schizonepetae volatile oil, spare；
4) the fresh sesame flower weighed is ground crushing with mortar, and solidliquid mixture after grinding is taken out with funnel
Filter retains filtrate；Then filtrate is poured into separatory funnel, makees extracting solution with ethyl acetate；Organic layer is extracted, sesame flower is obtained
Extracting solution；
5) the fresh phoenix tree leaf weighed is ground crushing with mortar, and solidliquid mixture after grinding is filtered, protected
Reserved filtrate；Then filtrate is poured into separatory funnel, makees extracting solution with ethyl acetate；Organic layer is extracted, phoenix tree leaf extraction is obtained
Liquid；
6) the extracting solution A obtained, extracting solution B, sesame flower extracting solution and Chinese parasol tree leaf extract are merged, is steamed with rotation
After hair instrument progress vacuum is spin-dried for solvent, mixed extract C is obtained；And the mixed extract C is stirred with the Herba Schizonepetae volatile oil
After mixing mixing, medicament crude product D is obtained；
7) by glycerin monostearate and sulphur emulsifiable paste according to mass ratio 5:1 carries out proportioning mixing, while by medicament obtained
Crude product D is stirred together, and carries out Heat preservation, forms white paste；
8) it will be carried out in the white paste injection high pressure homogenizer high-pressure homogeneous to get to target ointment.
Wherein, the temperature being heated at reflux to mixture with absolute ethyl alcohol in step 1) is controlled at 80~85 DEG C, while hot
50 DEG C are not less than to the temperature that phegma is filtered.
Wherein, Herba Schizonepetae volatile oil described in step 3) needs to be positioned over shady and cool closed place's storage.
Wherein, the extracting solution A obtained, extracting solution B, sesame flower extracting solution and Chinese parasol tree leaf extract are used in step 6)
Beaker merges, and 3A type molecular sieves are added into the beaker and are stirred, and after stirring 24 hours, then uses Rotary Evaporators
It carries out vacuum and is spin-dried for solvent.
It wherein, can in the mortar during being ground with mortar to the fresh sesame flower weighed in step 4)
5~8g quartz sands are added as grinding agent.
One, for the clinical test of verruca vulgaris patient.
1, subjects：250 verruca vulgaris patients, man 165, female 85.
2, therapy
250 verruca vulgaris patients are divided by treatment group's (totally four groups of Examples 1 to 4) and control using the principle of parallel control
Group (totally one group), every group of 50 patients.
Through statistical analysis, each group Gender, age, the course of disease, the there was no significant difference (P such as grading>0.05), have
There is comparativity.
Treatment group：Behind normal saline flushing cleaning affected part, verruca vulgaris ointment produced by the present invention is smeared in affected part, daily
2 times.
Control group：Painting goes to wart spirit cream, application method and the same treatment group of the frequency with rehabilitation source verruca vulgaris plantar wart.
3, criterion：
(1) effective：Verruca vulgaris affected part symptom disappears, and the surface of a wound heals completely, no pain；
(2) effectively：Cardinal symptom disappears, and the surface of a wound heals substantially, there is slight trace；
(3) invalid：Verruca vulgaris affected part symptom is not improved.
Data after contrast test are recorded, the affected part number of days used that fully recovers is fewer, rehabilitation people in same time
Number more at most drug effect is better.
4, result on trial：It is shown in Table 1.
Table 1
The data recorded by table 1 in two weeks, are suffered from it is found that behind the verruca vulgaris ointment coating affected part that the present invention is prepared
The illness of person all disappears, and the surface of a wound heals completely, and the ointment slowly effect in control group, and needs application healing time longer,
And found in later stage long-term observation, the same affected part of some patients is also reoccurred the illness of the verruca vulgaris.
Model case：
1. Lv XX, man, 32 years old, no other illnesss was done manual work in other places for a long time in one's early years, and life is irregular.It now has returned to old
Family carries out simple crops cultivation.Verruca vulgaris is mainly grown at the back of the hand and middle finger of the right hand, and there are about 6 to granulate, medical history two
Year, after two weeks, verruca vulgaris affected part symptom disappears the verruca vulgaris ointment for preparing of the coating present invention, and the surface of a wound heals completely, third week mistake
Afterwards, the back of the hand is not seen abnormal completely, and observation in latter year, affected part is not recurred.
2. woods XX, man, 32 years old, real estate project manager needed to investigate building site for a long time, measure.Verruca vulgaris is main
It grows on right crus of diaphragm toe, there are about 3 to granulate, medical history 1 year, and verruca vulgaris ointment prepared by the coating present invention is after 8 days, main disease
Shape disappears, and the surface of a wound heals substantially, there is a slight trace, and after second week, the sole surface of a wound heals completely, observation, affected part in latter year
Do not recur.
3. Lee XX, female, 28 years old, no other illnesss, civil servant, rule of life.Verruca vulgaris is mainly grown on right eye skin, there are about
2 granulate, medical history half a year, and after a week, verruca vulgaris falls off verruca vulgaris ointment prepared by the coating present invention, and the surface of a wound heals substantially,
There is a slight trace, after second week, the surface of a wound heals completely, and observation in latter year, affected part is not recurred.
4. king XX, female, 40 years old, peasant woman followed husband to be in and manages aquaculture.Verruca vulgaris is mainly grown in the right crus of diaphragm sole heart
On, situation is more serious, has become lamellar growth, and medical history 3 years applies the verruca vulgaris ointment of the invention prepared after two weeks, sheet of wound
Face is healed substantially, there is slight trace, and after third week, the surface of a wound heals completely, and observation in latter year, affected part is not recurred.
Therefore, by the analysis of table 1 and model case it is found that the ointment for the treatment of verruca vulgaris prepared by the present invention, which has, cures week
Phase is as short as 1~2 week, can be effected a radical cure after application, will not recur again, and without any side effects to human body, in terms of process for producing
The preparation method of the ointment is relatively easy, and cost of material price is relatively low, is suitable for promoting and produce in batches.
Claims (8)
1. a kind of ointment for treating verruca vulgaris, which is characterized in that as follows including raw material components：Cicada slough, Radix Glycyrrhizae, peppermint, chaste tree
Mustard, sesame flower, phoenix tree leaf, glycerin monostearate and sulphur emulsifiable paste.
2. the ointment as described in claim 1 for treating verruca vulgaris, which is characterized in that the parts by weight of the raw material components
For：
3. the ointment as claimed in claim 2 for treating verruca vulgaris, which is characterized in that the parts by weight of the raw material components
For：
4. a kind of preparation method as described in any one of claims 1-3 for treating verruca vulgaris ointment, which is characterized in that including
Following preparation process：
1) cicada slough and Radix Glycyrrhizae after drying are weighed, and the two is ground crushing, three-necked flask is poured the mixture into after crushing
In, it is used in combination absolute ethyl alcohol to be heated at reflux mixture；Then phegma is filtered while hot, retains filtrate, be made and carry
Take liquid A；
2) it weighs peppermint young leaves and is put into beaker and is added into the beaker anhydrous ethanol solvent after being cleaned drying, 50
~60 DEG C of heating water baths are after 24 hours, after taking out peppermint blade, retain extracting solution, obtain extracting solution B；
3) it weighs after schizonepeta crushes and is put into the three-necked flask for being contained with deionized water, stirring distillation, to distillate centrifugal treating,
It is stood after centrifugation, takes upper layer fluid to get Herba Schizonepetae volatile oil, it is spare；
4) the fresh sesame flower weighed is ground crushing with mortar, and solidliquid mixture after grinding is filtered with funnel,
Retain filtrate；Then filtrate is poured into separatory funnel, makees extracting solution with ethyl acetate；Organic layer is extracted, sesame flower is obtained and carries
Take liquid；
5) the fresh phoenix tree leaf weighed is ground crushing with mortar, and solidliquid mixture after grinding is filtered, retain filter
Liquid；Then filtrate is poured into separatory funnel, makees extracting solution with ethyl acetate；Organic layer is extracted, Chinese parasol tree leaf extract is obtained；
6) the extracting solution A obtained, extracting solution B, sesame flower extracting solution and Chinese parasol tree leaf extract are merged, uses Rotary Evaporators
After progress vacuum is spin-dried for solvent, mixed extract C is obtained；And the mixed extract C and the Herba Schizonepetae volatile oil are stirred mixed
After conjunction, medicament crude product D is obtained；
7) by glycerin monostearate and sulphur emulsifiable paste according to mass ratio 5:1 carries out proportioning mixing, while medicament obtained slightly being produced
Object D is stirred together, and carries out Heat preservation, forms white paste；
8) it will be carried out in the white paste injection high pressure homogenizer high-pressure homogeneous to get to target ointment.
5. the preparation method as claimed in claim 4 for treating verruca vulgaris ointment, which is characterized in that with anhydrous in step 1)
The temperature that ethyl alcohol is heated at reflux mixture is controlled at 80~85 DEG C, is not less than while hot to the temperature that phegma is filtered
50℃。
6. the preparation method as claimed in claim 4 for treating verruca vulgaris ointment, which is characterized in that chaste tree described in step 3)
Mustard volatile oil needs to be positioned over shady and cool closed place's storage.
7. the preparation method as claimed in claim 4 for treating verruca vulgaris ointment, which is characterized in that will be made in step 6)
The extracting solution A, extracting solution B, sesame flower extracting solution and Chinese parasol tree leaf extract merged with beaker, and into the beaker
3A type molecular sieves are added to be stirred, after stirring 24 hours, then carries out vacuum with Rotary Evaporators and is spin-dried for solvent.
8. the preparation method as claimed in claim 4 for treating verruca vulgaris ointment, which is characterized in that weighing in step 4)
During good fresh sesame flower is ground with mortar, 5~8g quartz sands can be added in the mortar as grinding agent.
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Cited By (2)
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| CN108355042A (en) * | 2018-05-28 | 2018-08-03 | 陈雨薇 | A kind of anti-inflammatory analgetic ointment and preparation method thereof |
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| CN105998405A (en) * | 2016-06-24 | 2016-10-12 | 安徽高山药业有限公司 | Pine needle compound ointment for treating seborrheic dermatitis and preparation method |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108355125A (en) * | 2018-05-28 | 2018-08-03 | 陈雨薇 | Anti- chap ointment of one kind and preparation method thereof |
| CN108355042A (en) * | 2018-05-28 | 2018-08-03 | 陈雨薇 | A kind of anti-inflammatory analgetic ointment and preparation method thereof |
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