CN109316516A - A kind of plaster and preparation method thereof for treating rheumatism, rheumatoid arthritis, scapulohumeral periarthritis, osteoproliferation, cervical spondylosis - Google Patents
A kind of plaster and preparation method thereof for treating rheumatism, rheumatoid arthritis, scapulohumeral periarthritis, osteoproliferation, cervical spondylosis Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/83—Thymelaeaceae (Mezereum family), e.g. leatherwood or false ohelo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/36—Skin; Hair; Nails; Sebaceous glands; Cerumen; Epidermis; Epithelial cells; Keratinocytes; Langerhans cells; Ectodermal cells
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/58—Reptiles
- A61K35/583—Snakes; Lizards, e.g. chameleons
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/286—Carthamus (distaff thistle)
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
- A61K36/716—Clematis (leather flower)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/46—Ingredients of undetermined constitution or reaction products thereof, e.g. skin, bone, milk, cotton fibre, eggshell, oxgall or plant extracts
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7084—Transdermal patches having a drug layer or reservoir, and one or more separate drug-free skin-adhesive layers, e.g. between drug reservoir and skin, or surrounding the drug reservoir; Liquid-filled reservoir patches
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/15—Preparation or pretreatment of starting material involving mechanical treatment, e.g. chopping up, cutting or grinding
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
Abstract
The present invention discloses a kind of plaster and preparation method thereof for treating rheumatism, rheumatoid arthritis, scapulohumeral periarthritis, osteoproliferation, cervical spondylosis.Using girald daphne bark, safflower, Radix Notoginseng, the root of Chinese clematis, agkistrodon, semen brassicae, pangolin and Chloranthus glaber root as bulk pharmaceutical chemicals in the black powder layer of paste of plaster of the present invention, the effect of playing clearing damp, anti-inflammatory, analgesia, acupuncture-stimulating blood stasis dispersing altogether has significant therapeutic effect to the bones class disease such as rheumatism, rheumatoid arthritis, scapulohumeral periarthritis, osteoproliferation, cervical spondylosis；Addition is used in compounding using sesame oil, pepper volatile oil, Rhizoma Zingiberis volatile oil and tangerine peel volatile oil in plaster substrate, it is synergistic in combination with the effect of borneol and Moschus, improve Transdermal absorption effect of plaster, making plaster, drug effect is rapid-action in use, obvious effect.Preparation method of the present invention, it is creative to extract girald daphne bark, safflower and Radix Notoginseng using ethyl alcohol, then the root of Chinese clematis is extracted with alcohol extract, further promotes the action speed and therapeutic effect of plaster.
Description
Technical field
The present invention relates to traditional Chinese medicine plaster technical fields, and in particular to a kind of to treat rheumatism, rheumatoid arthritis, shoulder
Inflammation, osteoproliferation, plaster of cervical spondylosis and preparation method thereof.
Background technique
Plaster is the external therapy of China's medicine, with Chinese medical discrimination theory compounding pharmaceutical ingredient, then in conjunction with plaster base
Matter is made thick and has the coating substance of certain viscosity in patch, and when use sticks on affected part or human meridian point
Place, drug ingedient reach subcutaneous tissue by Cutaneous permeation, in the relative advantage for locally generating drug concentration, to play stronger
Pharmacological action.Meanwhile after drug penetrates skin and mucous membrane, enter body circulation by blood vessel or lymphatic vessel, can produce systemic medicine
Object effect achievees the purpose that treat disease.
The osteopathy such as rheumatism, rheumatoid arthritis, scapulohumeral periarthritis, osteoproliferation, cervical spondylosis, usually with arthralgia, it is aching and tired,
Numbness, limitation of activity, stiffness and deforming are main clinical manifestation, serious to be unable to leave the bed, is in great pain, can't take care of oneself.It is right
It is varied in the therapeutic modality of these diseases, there are manipulation, doctor trained in Western medicine injection treatment etc., but it is unpunctual to massage, and often goes out
The complication such as existing cauda equina injury；Doctor trained in Western medicine injection treatment is generally only temporary remission, palliative.Therefore gradually
Occur in such a way that black plaster progress osteopathy prepared by Chinese medical discrimination theory is treated.However the black cream of traditional treatment osteopathy
Often there is the defects of onset time is long, plaster easy flowing pollution clothing in medicine.
Summary of the invention
In order to overcome the drawbacks of the prior art, an object of the present invention be to provide it is a kind of treat rheumatism, rheumatoid close
The plaster of inflammation, scapulohumeral periarthritis, osteoproliferation, cervical spondylosis is saved, the Transdermal absorption performance having had, rapid-action, therapeutic effect is significant, and
It is not easy flowing pollution clothing.
Meanwhile the present invention also resides in and provides a kind of preparation method of plaster.
In order to achieve the goal above, the technical scheme adopted by the invention is that:
A kind of plaster for treating rheumatism, rheumatoid arthritis, scapulohumeral periarthritis, osteoproliferation, cervical spondylosis, so that the used time is close to skin
Side be inside, from inside to outside successively include alginate layer, black powder layer of paste and patch layer；Wherein alginate
Layer include include the annular gel ring at black powder layer of paste edge, and the gel arranged in a crossed manner in length and breadth being arranged in annular gel ring
Drug release through-hole is laid on item, gel strips and gel ring；
Black powder layer of paste is prepared by following raw material in parts by weight: 15 ~ 20 parts of girald daphne bark, 8 ~ 10 parts of Radix Notoginseng, agkistrodon 3 ~ 4
Part, 4 ~ 5 parts of semen brassicae, 2 ~ 3 parts of the root of Chinese clematis, 8 ~ 10 parts of pangolin, 10 ~ 12 parts of safflower, 4 ~ 5 parts of Chloranthus glaber root, plaster substrate 150
~ 200 parts；
Wherein plaster substrate is prepared by following raw material in parts by weight: 45 ~ 50 parts of rosin, 40 ~ 45 parts of vaseline, beeswax 10
~ 12 parts, 4 ~ 5 parts of sesame oil, 2 ~ 3 parts of house oil, 3 ~ 4 parts of moxa, 1 ~ 2 part of borneol, 1 ~ 1.5 part of Moschus, pepper volatile oil 0.5 ~ 0.8
Part, 1 ~ 2 part of Rhizoma Zingiberis volatile oil, 1 ~ 2 part of tangerine peel volatile oil.
Optionally, aluminite powder is contained in the alginate layer.It can produce infrared therapeutic effect.
The preparation method of the plaster of above-mentioned treatment rheumatism, rheumatoid arthritis, scapulohumeral periarthritis, osteoproliferation, cervical spondylosis, packet
Include following operating procedure:
1) drug ingedient is handled: after taking girald daphne bark, safflower and Radix Notoginseng to crush in parts by weight using ethyl alcohol as extraction solvent into
Row extraction, filters to obtain the first filtrate and first dregs of a decoction after the completion of extraction；Then take the root of Chinese clematis crush after be added in the first filtrate into
Row extraction, filters to obtain the second filtrate and second dregs of a decoction after the completion of extraction；Second filtrate is carried out to be concentrated to give medicinal extract；Take agkistrodon,
Semen brassicae, pangolin and Chloranthus glaber root crush, and obtain mixed powder；First dregs of a decoction, second dregs of a decoction, mixed powder are added in medicinal extract
It is mixed evenly, obtains medicinal mixture；
2) it prepares plaster substrate: rosin being taken to be brewed into dark brown；It takes vaseline to be brewed into liquid, liquid vaseline is added and is boiled
In the rosin of completion, then sequentially adds beeswax, sesame oil, house oil, moxa, borneol, Moschus, pepper volatile oil, rhizoma zingiberis and wave
Hair oil, tangerine peel volatile oil, are mixed evenly, obtain plaster substrate；
3) it prepares black ointment: the medicinal mixture of step 1) preparation being added in the plaster substrate of step 2 preparation, is brewed into black
Color is to get black ointment；
4) black ointment prepared by step 3) is spread out in formation black powder layer of paste in patch, takes alginate as desired in black powder
Alginate layer is formed in layer of paste.
Optionally, the dosage of ethyl alcohol is girald daphne bark, 3 ~ 4 times of safflower and Radix Notoginseng total weight in step 1).
Optionally, girald daphne bark in step 1), safflower and Radix Notoginseng extraction method particularly includes: extract 3 at a temperature of 50 ~ 60 DEG C
~ 4 hours；It is extracted in the first filtrate of root of Chinese clematis addition in step 1) method particularly includes: it is small that 1 ~ 2 is extracted at a temperature of 40 ~ 50 DEG C
When.
Optionally, girald daphne bark, safflower, Radix Notoginseng, the root of Chinese clematis, agkistrodon, semen brassicae, pangolin and Chloranthus glaber root in step 1)
It is crushed to 100 ~ 200 mesh.
It optionally, is to be concentrated under reduced pressure into relative density to be by the specific method that the second filtrate is concentrated to give filtrate in step 1)
1.05 ~ 1.10 obtain medicinal extract.
Pepper volatile oil, Rhizoma Zingiberis volatile oil, tangerine peel volatile oil are commercial product；Alginate is conventionally
Manufactured alginate hydrogel is prepared when needing in alginate layer containing aluminite powder in alginate hydrogel
Aluminite powder is added in the process.
Plaster of the present invention, in one side black powder layer of paste with girald daphne bark, safflower, Radix Notoginseng, the root of Chinese clematis, agkistrodon, semen brassicae, wear
Naze and Chloranthus glaber root are bulk pharmaceutical chemicals, according to monarch reasonable compatibility, using girald daphne bark and safflower as monarch drug in a prescription, Radix Notoginseng and pangolin
For ministerial drug, agkistrodon, semen brassicae, the root of Chinese clematis and Chloranthus glaber root are adjuvant, and synergistic effect is played clearing damp altogether, anti-inflammatory, analgesia, led to
The effect of network stagnation resolvation, has the bones class disease such as rheumatism, rheumatoid arthritis, scapulohumeral periarthritis, osteoproliferation, cervical spondylosis significant
Therapeutic effect；On the other hand, addition is volatilized using sesame oil, pepper volatile oil, Rhizoma Zingiberis volatile oil and tangerine peel in plaster substrate
Oil is used in compounding, synergistic in combination with the effect of borneol and Moschus, improves Transdermal absorption effect of plaster, plaster is made to exist
Drug onset of action is fast in use process, obvious effect.
Meanwhile plaster setting alginate hydrogel layer of the present invention avoids the excessive pollution clothes of plaster, and also overcomes
Patient is easy to produce the defect of skin tight feeling behind the deposited affected part of traditional plaster.
Preparation method of the present invention, it is creative to extract girald daphne bark, safflower and Radix Notoginseng using ethyl alcohol, then use ethyl alcohol
Leaching liquor extracts the root of Chinese clematis, further promotes the action speed and therapeutic effect of plaster.
Specific embodiment
The technical scheme of the invention is described in detail through specific implementation examples.
Alginate layer is the alginate layer containing aluminite powder in following embodiments, and the quality of aluminite powder contains
Amount is 1%.
Embodiment 1
A kind of plaster for treating rheumatism, rheumatoid arthritis, scapulohumeral periarthritis, osteoproliferation, cervical spondylosis, so that the used time is close to skin
Side be inside, from inside to outside successively include alginate layer, black powder layer of paste and patch layer；Wherein alginate
Layer include include the annular gel ring at black powder layer of paste edge, and the gel arranged in a crossed manner in length and breadth being arranged in annular gel ring
Drug release through-hole is laid on item, gel strips and gel ring；
Black powder layer of paste is prepared by following raw material in parts by weight: 18 parts of girald daphne bark, 9 parts of Radix Notoginseng, 3.5 parts of agkistrodon, sinapsis alba
Sub 3.5 parts, 2.5 parts of the root of Chinese clematis, 9 parts of pangolin, 11 parts of safflower, 4.5 parts of Chloranthus glaber root, 180 parts of plaster substrate；
Wherein plaster substrate is prepared by following raw material in parts by weight: 48 parts of rosin, 42 parts of vaseline, 11 parts of beeswax, sesame
4.5 parts of sesame oil, 2.5 parts of house oil, 3.5 parts of moxa, 1.5 parts of borneol, 1.2 parts of Moschus, 0.7 part of pepper volatile oil, Rhizoma Zingiberis volatile oil
1.5 parts, 1.5 parts of tangerine peel volatile oil.
The present embodiment treats the preparation side of the plaster of rheumatism, rheumatoid arthritis, scapulohumeral periarthritis, osteoproliferation, cervical spondylosis
Method, including following operating procedure:
1) drug ingedient is handled: taking girald daphne bark, safflower and Radix Notoginseng to be crushed to 100 ~ 200 mesh in parts by weight, using ethyl alcohol conduct
Extraction solvent is extracted, and ethanol consumption is 3.5 times of girald daphne bark, safflower and Radix Notoginseng gross mass, extracts 3.5 at a temperature of 55 DEG C
Hour, the first filtrate and first dregs of a decoction are filtered to obtain after the completion of extraction；Then it takes the root of Chinese clematis to be crushed to 100 ~ 200 mesh, is added first
It is extracted in filtrate, is extracted 1.5 hours at a temperature of 45 DEG C, the second filtrate and second dregs of a decoction are filtered to obtain after the completion of extraction；It will
Second filtrate be concentrated under reduced pressure into relative density be 1.08 medicinal extract；Take agkistrodon, semen brassicae, pangolin and Chloranthus glaber root powder
100 ~ 200 mesh are broken to, mixed powder is obtained；First dregs of a decoction, second dregs of a decoction, mixed powder are added in medicinal extract and are mixed evenly,
Obtain medicinal mixture；
2) it prepares plaster substrate: rosin being taken to be brewed into dark brown；It takes vaseline to be brewed into liquid, liquid vaseline is added and is boiled
In the rosin of completion, then sequentially adds beeswax, sesame oil, house oil, moxa, borneol, Moschus, pepper volatile oil, rhizoma zingiberis and wave
Hair oil, tangerine peel volatile oil, are mixed evenly, obtain plaster substrate；
3) it prepares black ointment: the medicinal mixture of step 1) preparation being added in the plaster substrate of step 2 preparation, is brewed into black
Color is to get black ointment；
4) black ointment prepared by step 3) is spread out in formation black powder layer of paste in patch, takes alginate as desired in black powder
Alginate layer is formed in layer of paste.
Embodiment 2
A kind of plaster for treating rheumatism, rheumatoid arthritis, scapulohumeral periarthritis, osteoproliferation, cervical spondylosis, so that the used time is close to skin
Side be inside, from inside to outside successively include alginate layer, black powder layer of paste and patch layer；Wherein alginate
Layer include include the annular gel ring at black powder layer of paste edge, and the gel arranged in a crossed manner in length and breadth being arranged in annular gel ring
Drug release through-hole is laid on item, gel strips and gel ring；
Black powder layer of paste is prepared by following raw material in parts by weight: 15 parts of girald daphne bark, 8 parts of Radix Notoginseng, 3 parts of agkistrodon, semen brassicae 4
Part, 2 parts of the root of Chinese clematis, 8 parts of pangolin, 10 parts of safflower, 4 parts of Chloranthus glaber root, 150 parts of plaster substrate；
Wherein plaster substrate is prepared by following raw material in parts by weight: 45 parts of rosin, 40 parts of vaseline, 10 parts of beeswax, sesame
4 parts of sesame oil, 2 parts of house oil, 3 parts of moxa, 1 part of borneol, 1 part of Moschus, 0.5 part of pepper volatile oil, 1 part of Rhizoma Zingiberis volatile oil, tangerine peel are waved
1 part of hair oil.
The present embodiment treats the preparation side of the plaster of rheumatism, rheumatoid arthritis, scapulohumeral periarthritis, osteoproliferation, cervical spondylosis
Method, including following operating procedure:
1) drug ingedient is handled: taking girald daphne bark, safflower and Radix Notoginseng to be crushed to 100 ~ 200 mesh in parts by weight, using ethyl alcohol conduct
Extraction solvent is extracted, and ethanol consumption is 3 times of girald daphne bark, safflower and Radix Notoginseng gross mass, and it is small to extract 4 at 50 °C
When, the first filtrate and first dregs of a decoction are filtered to obtain after the completion of extraction；Then it takes the root of Chinese clematis to be crushed to 100 ~ 200 mesh, the first filter is added
It is extracted in liquid, is extracted 2 hours at a temperature of 40 DEG C, the second filtrate and second dregs of a decoction are filtered to obtain after the completion of extraction；By second
Filtrate be concentrated under reduced pressure into relative density be 1.05 medicinal extract；Agkistrodon, semen brassicae, pangolin and Chloranthus glaber root is taken to be crushed to
100 ~ 200 mesh, obtain mixed powder；First dregs of a decoction, second dregs of a decoction, mixed powder are added in medicinal extract and are mixed evenly, medicine is obtained
Object mixture；
2) it prepares plaster substrate: rosin being taken to be brewed into dark brown；It takes vaseline to be brewed into liquid, liquid vaseline is added and is boiled
In the rosin of completion, then sequentially adds beeswax, sesame oil, house oil, moxa, borneol, Moschus, pepper volatile oil, rhizoma zingiberis and wave
Hair oil, tangerine peel volatile oil, are mixed evenly, obtain plaster substrate；
3) it prepares black ointment: the medicinal mixture of step 1) preparation being added in the plaster substrate of step 2 preparation, is brewed into black
Color is to get black ointment；
4) black ointment prepared by step 3) is spread out in formation black powder layer of paste in patch, takes alginate as desired in black powder
Alginate layer is formed in layer of paste.
Embodiment 3
A kind of plaster for treating rheumatism, rheumatoid arthritis, scapulohumeral periarthritis, osteoproliferation, cervical spondylosis, so that the used time is close to skin
Side be inside, from inside to outside successively include alginate layer, black powder layer of paste and patch layer；Wherein alginate
Layer include include the annular gel ring at black powder layer of paste edge, and the gel arranged in a crossed manner in length and breadth being arranged in annular gel ring
Drug release through-hole is laid on item, gel strips and gel ring；
Black powder layer of paste is prepared by following raw material in parts by weight: 20 parts of girald daphne bark, 10 parts of Radix Notoginseng, 4 parts of agkistrodon, semen brassicae
5 parts, 3 parts of the root of Chinese clematis, 10 parts of pangolin, 12 parts of safflower, 5 parts of Chloranthus glaber root, 200 parts of plaster substrate；
Wherein plaster substrate is prepared by following raw material in parts by weight: 50 parts of rosin, 45 parts of vaseline, 12 parts of beeswax, sesame
5 parts of sesame oil, 3 parts of house oil, 4 parts of moxa, 2 parts of borneol, 1.5 parts of Moschus, 0.8 part of pepper volatile oil, 2 parts of Rhizoma Zingiberis volatile oil, tangerine peel
2 parts of volatile oil.
The present embodiment treats the preparation side of the plaster of rheumatism, rheumatoid arthritis, scapulohumeral periarthritis, osteoproliferation, cervical spondylosis
Method, including following operating procedure:
1) drug ingedient is handled: taking girald daphne bark, safflower and Radix Notoginseng to be crushed to 100 ~ 200 mesh in parts by weight, using ethyl alcohol conduct
Extraction solvent is extracted, and ethanol consumption is 4 times of girald daphne bark, safflower and Radix Notoginseng gross mass, and it is small that 3 are extracted at a temperature of 60 DEG C
When, the first filtrate and first dregs of a decoction are filtered to obtain after the completion of extraction；Then it takes the root of Chinese clematis to be crushed to 100 ~ 200 mesh, the first filter is added
It is extracted in liquid, is extracted 1 hour at 50 °C, the second filtrate and second dregs of a decoction are filtered to obtain after the completion of extraction；By second
Filtrate be concentrated under reduced pressure into relative density be 1.10 medicinal extract；Agkistrodon, semen brassicae, pangolin and Chloranthus glaber root is taken to be crushed to
100 ~ 200 mesh, obtain mixed powder；First dregs of a decoction, second dregs of a decoction, mixed powder are added in medicinal extract and are mixed evenly, medicine is obtained
Object mixture；
2) it prepares plaster substrate: rosin being taken to be brewed into dark brown；It takes vaseline to be brewed into liquid, liquid vaseline is added and is boiled
In the rosin of completion, then sequentially adds beeswax, sesame oil, house oil, moxa, borneol, Moschus, pepper volatile oil, rhizoma zingiberis and wave
Hair oil, tangerine peel volatile oil, are mixed evenly, obtain plaster substrate；
3) it prepares black ointment: the medicinal mixture of step 1) preparation being added in the plaster substrate of step 2 preparation, is brewed into black
Color is to get black ointment；
4) black ointment prepared by step 3) is spread out in formation black powder layer of paste in patch, takes alginate as desired in black powder
Alginate layer is formed in layer of paste.
Comparative example 1
This comparative example adjusts pepper volatile oil difference from example 1 is that save Rhizoma Zingiberis volatile oil and tangerine peel volatile oil
Dosage be 3.7 parts, other are the same as embodiment 1.
Comparative example 2
This comparative example adjusts tangerine peel volatile oil difference from example 1 is that save pepper volatile oil and Rhizoma Zingiberis volatile oil
Dosage be 3.7 parts, other are the same as embodiment 1.
Comparative example 3
This comparative example adjusts Rhizoma Zingiberis volatile oil difference from example 1 is that save pepper volatile oil and tangerine peel volatile oil
Dosage be 3.7 parts, other are the same as embodiment 1.
Comparative example 4
This comparative example difference from example 1 is that, the processing mode of the root of Chinese clematis is different in drug ingedient treatment process,
This comparative example, which is saved, extracts the root of Chinese clematis with the first filtrate, by the root of Chinese clematis directly with agkistrodon, semen brassicae, pangolin and Chloranthus glaber
Root is pulverized and mixed to obtain mixed powder, other are the same as embodiment 1.
Comparative example 5
This comparative example difference from example 1 is that, the processing mode of the root of Chinese clematis is different in drug ingedient treatment process,
Ethyl alcohol is added after crushing the root of Chinese clematis with girald daphne bark, Radix Notoginseng and safflower in this comparative example to extract, other are the same as embodiment 1.
Comparative example 6
This comparative example difference from example 1 is that, the processing side of semen brassicae and Radix Notoginseng in drug ingedient treatment process
Formula is different, crushes to be added in ethyl alcohol by girald daphne bark, semen brassicae and safflower in this comparative example and extract, by Radix Notoginseng and agkistrodon,
Pangolin and Chloranthus glaber root are pulverized and mixed to obtain mixed powder, other are the same as embodiment 1.
1 skin permeation test in vitro of test example
Test method: being using Franz diffusion cell, mainly to have with Chinese medicine in black plaster through medium with piggy skin of abdomen
Imitating ingredients Biogenic alkali, flavone compound, glycosides compound is index, black plaster prepared by measurement embodiment 1, comparative example 1 ~ 6
Drug Percutaneous Absorption performance, alkaloid, flavone compound, glycosides compound content examined using high performance liquid chromatography
Survey, the alkaloid that detects, flavone compound, glycosides compound content size be 1 > comparative example of embodiment, 6 > comparative example
5 > comparative example, 4 > comparative example, 2 > comparative example, 3 > comparative example 1, the result surface embodiment 1 preparation black plaster in effective component
Transdermal absorption performance it is best, illustrate pepper volatile oil, Rhizoma Zingiberis volatile oil and the compound synergy of tangerine peel volatile oil, improve black cream
The Transdermal absorption performance of medicine, the processing mode of each bulk pharmaceutical chemicals limited in preparation method of the present invention, the especially root of Chinese clematis, the founder (of a school of learning)
Numb, safflower and Radix Notoginseng processing mode, further improves the Transdermal absorption performance of black plaster.
The test of 2 arthritis model of test example
1, rat model constructs: healthy rat 80, male, 180 ± 20g of weight, draws its right hind after rat routine disinfection
Directly, with syringe intracutaneous injection in the middle part of toes, every rat injects the full Freund's adjuvant of 0.1ml, first downward to inject half, then adjusts
Rotating the needle head is injected finish upwards；Wherein toes intracutaneous injection 0.1ml is raw behind the right side under the anesthesia of 10% urethane for 10 rats
Salt water is managed, as blank test group；Remaining 70 rat full Freund of toes intracutaneous injection behind the right side under the anesthesia of 10% urethane
Adjuvant 0.1ml, stochastic averagina are divided into A, B, C, D, E, F, G, and totally 7 groups；
2, administration mode: black plaster administration mode: corresponding black plaster is sticked on into right side ankle-joint, replacement in every two days is primary black
Plaster sticks 6 days, and wherein A group sticks the black plaster of the preparation of embodiment 1, B group sticks the black plaster of the preparation of comparative example 1, C group patch
Apply the black plaster of the preparation of comparative example 2, D group sticks the black plaster of the preparation of comparative example 3, E group sticks the black plaster of the preparation of comparative example 4, F
Group sticks the black plaster of the preparation of comparative example 5, G group sticks black plaster prepared by comparative example 6；
3: test result detection: detecting erythrocyte sedimentation rate (ESR), rheumatoid factor (RF) and the C reactive protein of different groups of rats respectively
(CRP), -1 β of serum IL, TNF-α, as a result shown in following Tables 1 and 2:
Table 1
Table 2
The data as shown in above-mentioned Tables 1 and 2 it is found that the black plaster for preparing of embodiment 1 and comparative example 1 ~ 6 to arthritic treatment
Efficacy performance is that embodiment 1 is better than better than comparative example 2 better than comparative example 3 better than comparative example 5 better than comparative example 4 better than comparative example 6
Comparative example 1, it can be seen that make pepper volatile oil, Rhizoma Zingiberis volatile oil and tangerine peel volatile oil compounding in black plaster base in the present invention
With, and in preparation method creative selection girald daphne bark, Radix Notoginseng, safflower and the root of Chinese clematis processing mode, improve controlling for black plaster
Treat effect.
The clinical drug effect statistical test of test example 3:
1, the male with cervical spondylosis to 50 ages at 40 ~ 50 years old is sticked using black plaster prepared by the present embodiment 1
Treatment, sticks 15 days, replaces a plaster daily, and tracking statistics therapeutic effect has 45 patients to indicate treatment as the result is shown
Significant effect, symptom are obviously improved, and activity freely, has 3 patients to indicate that symptom has improvement without obvious pain, activity, but living
It is dynamic still to keenly feel with certain, there are 2 patients to indicate that therapeutic effects are not significant, symptom is not improved.
2, the women with scapulohumeral periarthritis to 50 ages at 40 ~ 50 years old is carried out using black plaster prepared by the present embodiment 1
Application treatment sticks 15 days, replaces a plaster daily, and tracking statistics therapeutic effect has 46 patients to indicate as the result is shown
Therapeutic effect is significant, and symptom is obviously improved, and activity freely, has 2 patients to indicate that symptom has improvement without obvious pain, activity, but
It is activity still with certain pain, there are 2 patients to indicate that therapeutic effect is not significant, symptom is not improved.
3, the gerontal patient for 50 ages at 65 ~ 70 years old, these gerontal patients cause knee living due to osteoporosis
The not flexible black plaster progress application treatment for having obvious pain, preparing using the present embodiment 1 is moved, sticks 15 days, replaces one daily
Secondary plaster, tracking statistics therapeutic effect have 46 patients to indicate that symptom has improvement as the result is shown, and knee activity has change flexibly,
The movable pain of knee mitigates；There are 4 patients to indicate that therapeutic effect is unobvious, symptom is not improved.
Finally, it should be noted that the above embodiments are merely illustrative of the technical solutions of the present invention, rather than its limitations；Although
Present invention has been described in detail with reference to the aforementioned embodiments, those skilled in the art should understand that: it still may be used
To modify the technical solutions described in the foregoing embodiments or equivalent replacement of some of the technical features；
And these are modified or replaceed, technical solution of various embodiments of the present invention that it does not separate the essence of the corresponding technical solution spirit and
Range.
Claims (7)
1. a kind of plaster for treating rheumatism, rheumatoid arthritis, scapulohumeral periarthritis, osteoproliferation, cervical spondylosis, which is characterized in that with
When use close to the side of skin be inside, from inside to outside successively include alginate layer, black powder layer of paste and patch layer；Its
Middle alginate layer include include the annular gel ring at black powder layer of paste edge, and be arranged in annular gel ring in length and breadth
Drug release through-hole is laid on gel strips arranged in a crossed manner, gel strips and gel ring；
Black powder layer of paste is prepared by following raw material in parts by weight: 15 ~ 20 parts of girald daphne bark, 8 ~ 10 parts of Radix Notoginseng, agkistrodon 3 ~ 4
Part, 4 ~ 5 parts of semen brassicae, 2 ~ 3 parts of the root of Chinese clematis, 8 ~ 10 parts of pangolin, 10 ~ 12 parts of safflower, 4 ~ 5 parts of Chloranthus glaber root, plaster substrate 150
~ 200 parts；
Wherein plaster substrate is prepared by following raw material in parts by weight: 45 ~ 50 parts of rosin, 40 ~ 45 parts of vaseline, beeswax 10
~ 12 parts, 4 ~ 5 parts of sesame oil, 2 ~ 3 parts of house oil, 3 ~ 4 parts of moxa, 1 ~ 2 part of borneol, 1 ~ 1.5 part of Moschus, pepper volatile oil 0.5 ~ 0.8
Part, 1 ~ 2 part of Rhizoma Zingiberis volatile oil, 1 ~ 2 part of tangerine peel volatile oil.
2. the plaster for the treatment of rheumatism, rheumatoid arthritis, scapulohumeral periarthritis, osteoproliferation, cervical spondylosis as described in claim 1,
It is characterized in that, containing aluminite powder in the alginate layer.
3. treating the plaster of rheumatism, rheumatoid arthritis, scapulohumeral periarthritis, osteoproliferation, cervical spondylosis as described in claim 1
Preparation method, which is characterized in that including following operating procedure:
1) drug ingedient is handled: after taking girald daphne bark, safflower and Radix Notoginseng to crush in parts by weight using ethyl alcohol as extraction solvent into
Row extraction, filters to obtain the first filtrate and first dregs of a decoction after the completion of extraction；Then take the root of Chinese clematis crush after be added in the first filtrate into
Row extraction, filters to obtain the second filtrate and second dregs of a decoction after the completion of extraction；Second filtrate is carried out to be concentrated to give medicinal extract；Take agkistrodon,
Semen brassicae, pangolin and Chloranthus glaber root crush, and obtain mixed powder；First dregs of a decoction, second dregs of a decoction, mixed powder are added in medicinal extract
It is mixed evenly, obtains medicinal mixture；
2) it prepares plaster substrate: rosin being taken to be brewed into dark brown；It takes vaseline to be brewed into liquid, liquid vaseline is added and is boiled
In the rosin of completion, then sequentially adds beeswax, sesame oil, house oil, moxa, borneol, Moschus, pepper volatile oil, rhizoma zingiberis and wave
Hair oil, tangerine peel volatile oil, are mixed evenly, obtain plaster substrate；
3) it prepares black ointment: the medicinal mixture of step 1) preparation being added in the plaster substrate of step 2 preparation, is brewed into black
Color is to get black ointment；
4) black ointment prepared by step 3) is spread out in formation black powder layer of paste in patch, takes alginate as desired in black powder
Alginate layer is formed in layer of paste.
4. treating the plaster of rheumatism, rheumatoid arthritis, scapulohumeral periarthritis, osteoproliferation, cervical spondylosis as claimed in claim 3
Preparation method, which is characterized in that the dosage of ethyl alcohol is 3 ~ 4 times of girald daphne bark, safflower and Radix Notoginseng total weight in step 1).
5. treating the plaster of rheumatism, rheumatoid arthritis, scapulohumeral periarthritis, osteoproliferation, cervical spondylosis as claimed in claim 3
Preparation method, which is characterized in that girald daphne bark, safflower and Radix Notoginseng extract in step 1) method particularly includes: at a temperature of 50 ~ 60 DEG C
Extraction 3 ~ 4 hours；It is extracted in the first filtrate of root of Chinese clematis addition in step 1) method particularly includes: extract 1 at a temperature of 40 ~ 50 DEG C
~ 2 hours.
6. treating the plaster of rheumatism, rheumatoid arthritis, scapulohumeral periarthritis, osteoproliferation, cervical spondylosis as claimed in claim 3
Preparation method, which is characterized in that girald daphne bark, safflower, Radix Notoginseng, the root of Chinese clematis, agkistrodon, semen brassicae, pangolin and grass in step 1)
Coral root is crushed to 100 ~ 200 mesh.
7. treating the plaster of rheumatism, rheumatoid arthritis, scapulohumeral periarthritis, osteoproliferation, cervical spondylosis as claimed in claim 3
Preparation method, which is characterized in that the second filtrate is concentrated to give to the specific method of filtrate relatively close to be concentrated under reduced pressure into step 1)
Degree obtains medicinal extract for 1.05 ~ 1.10.
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| CN201811429589.1A CN109316516A (en) | 2018-11-28 | 2018-11-28 | A kind of plaster and preparation method thereof for treating rheumatism, rheumatoid arthritis, scapulohumeral periarthritis, osteoproliferation, cervical spondylosis |
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|---|---|---|---|
| CN201811429589.1A CN109316516A (en) | 2018-11-28 | 2018-11-28 | A kind of plaster and preparation method thereof for treating rheumatism, rheumatoid arthritis, scapulohumeral periarthritis, osteoproliferation, cervical spondylosis |
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|---|---|
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109771524A (en) * | 2019-03-15 | 2019-05-21 | 湖州德本生物科技有限公司 | A kind of joint discutient and analgesic plaster drug paste and preparation method thereof and application method |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1376475A (en) * | 2001-03-23 | 2002-10-30 | 郭振阳 | Medicine for threating rheumatism, rheumatoid disease, lumbar intervertebral disk protrusion, hyperosteogeny and ischias and its preparing process |
| CN106729586A (en) * | 2017-03-02 | 2017-05-31 | 河南省百草瑭蜡泥制品有限公司 | A kind of this energy of functional grass moxibustion ointment and its application method |
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2018
- 2018-11-28 CN CN201811429589.1A patent/CN109316516A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1376475A (en) * | 2001-03-23 | 2002-10-30 | 郭振阳 | Medicine for threating rheumatism, rheumatoid disease, lumbar intervertebral disk protrusion, hyperosteogeny and ischias and its preparing process |
| CN106729586A (en) * | 2017-03-02 | 2017-05-31 | 河南省百草瑭蜡泥制品有限公司 | A kind of this energy of functional grass moxibustion ointment and its application method |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109771524A (en) * | 2019-03-15 | 2019-05-21 | 湖州德本生物科技有限公司 | A kind of joint discutient and analgesic plaster drug paste and preparation method thereof and application method |
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