CN105232650B - A kind of ointment that treating scald and its preparation and application - Google Patents
A kind of ointment that treating scald and its preparation and application Download PDFInfo
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- CN105232650B CN105232650B CN201510718021.1A CN201510718021A CN105232650B CN 105232650 B CN105232650 B CN 105232650B CN 201510718021 A CN201510718021 A CN 201510718021A CN 105232650 B CN105232650 B CN 105232650B
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Abstract
The present invention relates to a kind of ointment for treating scald and its preparation and application, the ointment includes the raw material of following weight: glutton fat 32-48 parts by weight, giant salamander 32-48 parts by weight, sesame oil 12-18 parts by weight, polygonum cuspidate 1.6-2.4 parts by weight, radix scutellariae 1.6-2.4 parts by weight, borneol 0.8-1.2 parts by weight.The preparation method for the treatment of ointment for scald of the present invention includes the pretreatment of raw material, and grinding, fermentation stir into cream.Application method are as follows: the ointment is applied directly at scald wound, or is spread at scald wound after being applied on gauze or being made ointment gauze for ointment.The invention has the benefit that related theoretical according to Chinese medicine, lung governing skin and hair, gallbladder sovereignty weighing apparatus are shared said medicine, compatibility is reasonable, it is curative for effect, for relieving pain anti-infection at scald, and it can inhibit the bright face meronecrosis of patient, accelerate the division of cell, it is quick, without scar after healing.
Description
Technical field
The invention belongs to a kind of pharmaceutical preparations for treating scald, burn, electric injury and malicious running sore, and in particular to Yi Zhongzhi
Treat the ointment and its preparation and application of scald.
Background technique
Burn and scald often occurs in daily life, to the patient being in a bad way, if be not treated in time or malpractice,
The infection of wound is just easily caused, suppurates, fester, leaves permanent scar, What is more can threat to life.It is treating at present
In terms of burn and scald, the generally existing prescription of the Chinese patent drug clinically applied is complicated, at high cost；Exist in terms for the treatment of burn and scald common
Problem is weak curative effect, and the course for the treatment of is long, and anti-infection effect is poor, and Transdermal absorption is slow, and cross-infection easily occurs in therapeutic process, and severe one jeopardizes
Life, less serious case make skin graft or leave scar, have aggravated the economy and mental burden of patient.
Summary of the invention
In order to solve the above problems existing in the present technology, the present invention provides a kind of ointment for treating scald and its preparations
And application method.
The technical scheme adopted by the invention is as follows:
A kind of ointment for treating scald, the raw material including following weight: glutton fat 32-48 parts by weight, giant salamander 32-48
Parts by weight, sesame oil 12-18 parts by weight, polygonum cuspidate 1.6-2.4 parts by weight, radix scutellariae 1.6-2.4 parts by weight, borneol 0.8-1.2 weight
Part.
Further: a kind of ointment for treating scald: including raw material and each raw material parts by weight are as follows: including following weight
The raw material of part proportion: 40 parts by weight of glutton fat, 40 parts by weight of giant salamander, 15 parts by weight of sesame oil, 2 parts by weight of polygonum cuspidate, 2 weight of radix scutellariae
Part, 1 parts by weight of borneol.
A kind of preparation method for treating ointment for scald: its preparation process is as follows:
1) borneol, giant salamander, polygonum cuspidate, radix scutellariae are weighed respectively by above-mentioned weight ratio, crushing respectively is powder, spare；
2) giant salamander powder obtained in step 1) and sesame oil mixed fermentation are obtained into fermentation material, by resulting fermentation material and badger
Giant Knotweed Rhizome, Baical Skullcap Root obtained in rouge and step 1), borneol powder are stirred uniform pasty masses, by gained paste
Substance is sealed a period of time to get the ointment for the treatment of scald.
Further: giant salamander described in step 1) is made with the following method: dissecting, picks a bone after the giant salamander of freezing is cleaned
Removing natural air drying to moisture after internal organ is that 7-8% is spare.
Further: polygonum cuspidate described in step 1), radix scutellariae are pre-processed as follows, are weighed the polygonum cuspidate, radix scutellariae respectively, are washed
Natural air drying to moisture is spare after being 7-8% after net.
Further: glutton fat described in step 2) is made with the following method: taking its slaughter in the hibernation season of badger
Its fat composition enters pot, and the water for being equivalent to its fat composition quality 1/9-1/10 is added, is steamed completely with the moisture that mild fire is stewed to mixture
Fat is precipitated in hair, then filters gained fat up to glutton fat, finally saves backup gained glutton fat in a low temperature of 0 DEG C.
In the hibernation season slaughter of badger, the fat of badger is most thick at this time, is easy to obtain.The mild fire mild fire is that firepower is small and slow,
Temperature rises slowly, and moisture evaporation is slower.The clarification filtration of glutton fat is natural sedimentation one week, and upper layer fat eliminating is taken to filter impurity.
Further: fermentation material described in step 2) the preparation method comprises the following steps: sesame oil is clarified 60 days naturally after, take upper layer
Edible vegetable oil the giant salamander powder is added in the edible vegetable oil, normal temperature fermentation 10 weeks, stirred every 48 hours once to get.
Giant salamander powder is fermented in sesame oil be in order to allow respective ingredient to discharge completely and dissolve each other, so as to absorption of human body,
The cell of damage is brought back to life, the division of active somatic cell is accelerated.
Further: the pulverization process, the borneol, giant salamander, tiger after pulverization process being carried out using ball milling in step 1)
Cane, radix scutellariae powder diameter be 140 mesh or more.
Ball milling is the percussion and abrasive body and ball milling inner wall using the abrasive body (such as steel ball, cobblestone) to fall
Abrasive action and by crushing material and mix, can be used for dry grinding or wet-milling；Operating condition is good, and crushing carries out in closed machine,
There is no dust to fly upward；Can intermittently operated, can also operate continuously.
Further: the time that is sealed of gained pasty masses is 9-12 weeks in step 2).
Preferably: the application method of above-mentioned ointment is the ointment to be applied directly at scald wound, or ointment is applied
It is spread at scald wound on gauze or after ointment gauze is made.
To facilitate the understanding of the present invention, below in the present invention raw material and drug effect be further elaborated.
Glutton fat: being the active drug for the treatment of scald, burn by the fat extracted grease of badger.
Giant salamander (Classification system: Andrias davidianus), giant salamander fat in unsaturated fatty acid (UFA) up to
71.13%, wherein monounsaturated fatty acids (MUFA) is 42.18%, and polyunsaturated fatty acid (PUFA) is 28.15%, is had
ω -6 type the PUFA of health-care effect is 13.10%, and ω -3 type PUFA is 15.15%, contains a large amount of active collagens in giant salamander skin
Albumen (COLLAGEN) and epidermis activity bleach the factor (CHF), and human skin can be made to keep, and elasticity, lubrication are fine and smooth, health is white
Tender, referred to as beauty treatment whitening sage product have extremely strong beauty functions, and salamander skin powder can treat burn, scald, especially to face
Burn and scald treatment preventing from scar.
Polygonum cuspidate: for the dry rhizome and root of polygonaceae plant polygonum cuspidate Polygonum cuspidatum Sieb.et Zucc.,
It is clearing heat and detoxicating with removing dampness through diuresis and removing jaundice, removing blood stasis and acesodyne, relieving cough and reducing sputum effect.For jaundice with damp-heat pathogen, stranguria with turbid discharge, leukorrhagia, rheumatism numbness
Bitterly, carbuncle sore tumefacting virus, scald, menostasis, abdominal mass, instep beat damage, cough with lung heat.
Radix scutellariae (Classification system: Scutellaria baicalensis Georgi), alias Radix Scutellariae, tsuchikane tea root are yellow
The root of a kind of reed mentioned in ancient books is used as medicine, bitter, cold in nature, there is heat-clearing and damp-drying drug, purging fire for removing toxin, hemostasis, miscarriage prevention and other effects.Cure mainly warm heat disease, the upper respiratory tract
The diseases such as infection, cough with lung heat, neonatal jaundice caused by dampness-heat, pneumonia, dysentery, hemoptysis, hot eyes, threatened abortion, hypertension, carbuncle swells furuncle sore, " science
Civil medicinal herbs " record: washout wound has antisepsis.
Sesame oil: it containing unsaturated fatty acid and amino acid needed by human, occupies first of each vegetable oil.It is also rich in
The microelements such as vitamin and iron needed by human, zinc, copper, cholesterol level is well below animal tallow, containing especially rich
Rich vitamin E and than more rich linoleic acid, linoleic acid have and reduce blood lipid, softening blood vessel, reduce blood pressure, promote microcirculation
Effect.
Borneol: also known as piece brain, orange slices, L-Borneol, kapur, MEIHUA BINGPIAN, Dipterocarpus pilosus, plum blossom brain, borneol brain, Mei Bing
Deng, it is through steam distillation and to be recrystallized and obtained by composite family Blumea balsamifera cauline leaf or lauraceae plant borneol camphor tree branches and leaves, also useful turpentine
Oil is obtained through a series of chemical method techniques.It can be used for closing card coma, for red eye, swell pain, and sore throat aphtha swells for sore
Bitterly, it is not held back after bursting.
Application method of the invention: being directly coated on injury after cleaning, or ointment is applied on gauze (or ointment yarn is made
Cloth) spread on the surface of a wound.Depending on the daily dressing of surface of a wound situation or the next day dressing 1 time.To the uninfected surface of a wound through generally sterilize after on
Medicine can just add medicine to after having the surface of a wound of infection that need to remove secretion.It is averaged curative day 2-3 days to Superficial bums, deep II degree of burning
Hurt average curative day about 7-10 days, skin smooth is as before after healing, pore demutation, preventing from scar, has significant healing effect
Fruit.
The invention has the benefit that related theoretical according to Chinese medicine, lung governing skin and hair, gallbladder sovereignty weighing apparatus share said medicine,
Compatibility is reasonable, curative for effect, for relieving pain anti-infection at scald, and can inhibit the bright face meronecrosis of patient, accelerates point of cell
It splits, it is quick, without scar after healing.
Specific embodiment
Further explanation explanation is made to the present invention combined with specific embodiments below, it is pointed out that: the present invention is not
Following preferred forms are confined to, anyone can obtain other various forms of products under the inspiration of the present invention, but not
It is all that there is technical solution identical or similar to the present application by making any variation in its shape or structure, all fall within this
Within the protection scope of invention.
Embodiment one:
A kind of ointment for treating scald: including raw material and each raw material parts by weight be glutton fat: 32 parts by weight, 32 weight of giant salamander
Measure part, 12 parts by weight of sesame oil, 1.6 parts by weight of polygonum cuspidate, 1.6 parts by weight of radix scutellariae, 0.8 parts by weight of borneol.
Its making step are as follows: 1) in the hibernation season of badger, by its slaughter, its fat composition is taken to enter pot, addition is equivalent to its quality
1/9 water is stewed to the moisture evaporating completely of mixture with mild fire, fat is precipitated, then by gained fat clarification filtration up to badger
Rouge saves backup gained glutton fat in a low temperature of 0 DEG C.
By Semen sesami nigrum, 60 days internal pressures are squeezed into oil after maturation, and then natural sedimentation 55 days, take its upper layer edible vegetable oil, at -4 DEG C
It is saved backup under low temperature.
It is dissected after the giant salamander of freezing is cleaned, natural air drying to moisture is 10% after the internal organ that pick a bone；
Natural air drying to moisture is spare after being 10% after polygonum cuspidate, radix scutellariae are cleaned；
2) by borneol and treated that giant salamander, polygonum cuspidate, radix scutellariae ratio by weight weigh, and ball milling is that 140 mesh powder are standby
With；
3) giant salamander powder obtained in step 2) is proportionally added into sesame oil, spontaneous fermentation 10 weeks, every 42 hours
Primary fermentation material is stirred, by Giant Knotweed Rhizome, Baical Skullcap Root, borneol powder obtained in resulting fermentation material and glutton fat and step 2)
End stirs evenly to obtain pasty masses in proportion, and gained pasty masses are sealed 10 weeks ointment up to treatment scald.
Embodiment two:
A kind of ointment for treating scald: including raw material and each raw material parts by weight are as follows: 40 parts by weight of glutton fat, 40 weight of giant salamander
Measure part, 15 parts by weight of sesame oil, 2 parts by weight of polygonum cuspidate, 2 parts by weight of radix scutellariae, 1 parts by weight of borneol.
Its making step are as follows: 1) in the hibernation season of badger, by its slaughter, its fat composition is taken to enter pot, addition is equivalent to its quality
1/10 water is stewed to the moisture evaporating completely of mixture with mild fire, fat is precipitated, then by gained fat clarification filtration up to badger
Rouge saves backup gained glutton fat in a low temperature of 0 DEG C.
By Semen sesami nigrum, 60 days internal pressures are squeezed into oil after maturation, and then natural sedimentation 60 days, take its upper layer edible vegetable oil, at 0 DEG C
It is saved backup under low temperature.
It is dissected after the giant salamander of freezing is cleaned, natural air drying to moisture is 8% after the internal organ that pick a bone；
Natural air drying to moisture is spare after being 8% after polygonum cuspidate, radix scutellariae are cleaned；
2) by borneol and treated that giant salamander, polygonum cuspidate, radix scutellariae ratio by weight weigh, and ball milling is that 200 mesh powder are standby
With；
3) giant salamander powder obtained in step 2) is proportionally added into sesame oil, spontaneous fermentation 10 weeks, every 48 hours
Primary fermentation material is stirred, by Giant Knotweed Rhizome, Baical Skullcap Root, borneol powder obtained in resulting fermentation material and glutton fat and step 2)
End stirs evenly to obtain pasty masses in proportion, and gained pasty masses are sealed 10 weeks ointment up to treatment scald.
Embodiment three:
A kind of ointment for treating scald: including raw material and each raw material parts by weight are as follows: 48 parts by weight of glutton fat, 48 weight of giant salamander
Measure part, 18 parts by weight of sesame oil, 2.4 parts by weight of polygonum cuspidate, 2.4 parts by weight of radix scutellariae, 1.2 parts by weight of borneol.
Its making step are as follows: 1) in the hibernation season of badger, by its slaughter, its fat composition is taken to enter pot, addition is equivalent to its quality
1/8 water is stewed to the moisture evaporating completely of mixture with mild fire, fat is precipitated, then by gained fat clarification filtration up to badger
Rouge saves backup gained glutton fat in a low temperature of 2 DEG C.
By Semen sesami nigrum, 60 days internal pressures are squeezed into oil after maturation, and then natural sedimentation 65 days, take its upper layer edible vegetable oil, at -4 DEG C
It is saved backup under low temperature.
It is dissected after the giant salamander of freezing is cleaned, natural air drying to moisture is 6% after the internal organ that pick a bone；
Natural air drying to moisture is spare after being 6% after polygonum cuspidate, radix scutellariae are cleaned；
2) by borneol and treated that giant salamander, polygonum cuspidate, radix scutellariae ratio by weight weigh, and ball milling is that 250 mesh powder are standby
With；
3) giant salamander powder obtained in step 2) is proportionally added into sesame oil, spontaneous fermentation 10 weeks, every 48 hours
Primary fermentation material is stirred, by Giant Knotweed Rhizome, Baical Skullcap Root, borneol powder obtained in resulting fermentation material and glutton fat and step 2)
End stirs evenly to obtain pasty masses in proportion, and gained pasty masses are sealed 10 weeks ointment up to treatment scald.
Use the method for externally applied drug of the present invention: burn and scald is not got blister, and ointment is directly applied to affected part.It, can if getting blister
Medicine is coated in around bubble, bubble is not punctured, is coated on a small quantity on bubble.The heavier excoriation of the condition of the injury, with sterile tissue gauze
Drug application is dipped in hurting face, face to be hurt is dry to be changed to direct coating.I degree is scalded, daily medication 1 to 2 time can fully recover from an illness for 3 days or so
More, II degree is scalded, and daily medication 3 to 4 times can fully recover for 3-5 days, III degree scald, from scald in 3 days, daily medication 3
To 4 times, in 3-7 days, daily medicine 2 to 3 times, after 7 days, daily medicine 1 to 2 time can fully recover for usual 7-10 days.Occurs scabies after coating
Itch, use is avoided in the allergic reactions such as fash.The present invention can both cure burn and scald, also equal to knife wound, bullet wound, electric injury and malicious running sore etc.
It can cure.
Clinical efficacy example:
Mr. Jiao, Shaanxi Province Ankang people, burn of catching fire accidentally at home on November 15th, 2010, burn surface area reach
65%, it does not improve in Xi'an hospitalize a couple of days, is treated using the present invention, be only clearly better, be used in conjunction with 3 days burn sites
This medicine is almost recovered for 9 days, pore demutation, no scar, and curative effect is significant.
Mrs Liang, outgoing to have a car accident, glass disintegrating slag large area scratches skin, after wound is cleared up in hemostasis, with this medicine treatment 5
Its recovery from illness, skin restore as before.
Mr. Wang, company, Shaanxi Province electrician, arm plays water voluntarily after cleaning wrapping by electric injury accidentally at work
Bubble, wound long 12cm, wide 4cm are sticked using ointment for treating scald, are deteriorated two days later, and redness flows dense, a burst of shouting pain, and the 3rd day with this medicine
Treatment, improves after 2 days, and decrustation is fully recovered after 6 days.
Clinical application statistics:
Scald can be divided into I degree scald (erythematous, erythrosis), II degree scald (vesiculovirus, affected part generates bubble), III
Degree scald (gangrenosum acne, skin, which is cut, to be fallen).To prove drug effect, inventor selectively selects 60 case observations, scalds below II degree
It hurts sb.'s feelings number 45, III degree scalds number 15, and medical history, the state of an illness, age, gender and comparable burn of former treatment method is selected to scald
Hurt patient 60 as control group, these patients are scalded from inpatient department and special outpatient clinic alternatively case subjects with the burning made a definite diagnosis
Hurt patient as observation object, wherein male, women each 30, the age is 70 years old hereinafter, the course of disease is unlimited.Test group: in use or not
It on the basis of often being handled with method with initial stage, discontinues medication, uses externally applied drug of the present invention.Control group: routinely treatment method processing,
Medication.Medication two group usages, dosages match, and the observation period is not more than three months.
It is as follows to observe result:
After the treatment of this medicine, 45 people of healing number, cure rate 100%, effective percentage 100%, equal nothing are scalded below II degree
Scar, III degree scald 15 people of healing number, cure rate 100%, effective percentage 100%, without scar.
| Group | Case load | Treatment of scald effect below II degree | III degree treatment of scald effect |
| Experimental group | 60 people | Symptom eliminates, wound healing | Pain disappears, epidermis healing |
| Control group | 60 people | Symptomatolytic 3/5 | Symptomatolytic 1/3 |
Claims (10)
1. a kind of ointment for treating scald, which is characterized in that bulk pharmaceutical chemicals are made of the raw material of following weight: glutton fat 32-
48 parts by weight, giant salamander 32-48 parts by weight, sesame oil 12-18 parts by weight, polygonum cuspidate 1.6-2.4 parts by weight, radix scutellariae 1.6-2.4 weight
Part, borneol 0.8-1.2 parts by weight.
2. ointment according to claim 1, which is characterized in that bulk pharmaceutical chemicals are made of the raw material of following weight: badger
40 parts by weight of rouge, 40 parts by weight of giant salamander, 15 parts by weight of sesame oil, 2 parts by weight of polygonum cuspidate, 2 parts by weight of radix scutellariae, 1 parts by weight of borneol.
3. a kind of preparation method of ointment as claimed in claim 1 or 2, which comprises the following steps:
1) borneol, giant salamander, polygonum cuspidate, radix scutellariae are weighed respectively by above-mentioned weight ratio, crushing respectively is powder, spare；
2) giant salamander powder obtained in step 1) and sesame oil mixed fermentation are obtained into fermentation material, by resulting fermentation material and glutton fat and
Giant Knotweed Rhizome, Baical Skullcap Root obtained in step 1), borneol powder are stirred uniform pasty masses, by gained pasty masses
A period of time is sealed to get the ointment for the treatment of scald.
4. preparation method according to claim 3, which is characterized in that giant salamander described in step 1) is made with the following method
: it is dissected after the giant salamander of freezing is cleaned, natural air drying to moisture is that 7-8% is spare after the internal organ that pick a bone.
5. preparation method according to claim 3, which is characterized in that polygonum cuspidate described in step 1), radix scutellariae carry out following pre-
Processing, weighs the polygonum cuspidate, radix scutellariae respectively, and natural air drying to moisture is spare after being 7-8% after cleaning.
6. preparation method according to claim 3, which is characterized in that glutton fat described in step 2) is made with the following method
: in the hibernation season of badger, by its slaughter, its fat composition is taken to enter pot, the water for being equivalent to its fat composition quality 1/9-1/10 is added, used
Mild fire is stewed to the moisture evaporating completely of mixture, and fat is precipitated, and then filters gained fat up to glutton fat, finally by gained badger
Rouge saves backup in a low temperature of 0 DEG C.
7. preparation method according to claim 3, which is characterized in that fermentation material described in step 2) the preparation method comprises the following steps:
After sesame oil is clarified 60 days naturally, upper layer edible vegetable oil is taken, the giant salamander powder is added in the edible vegetable oil, normal temperature fermentation 10 weeks,
Every 48 hours stirring once to get.
8. preparation method according to claim 3, which is characterized in that carried out at the crushing in step 1) using ball milling
Reason, the borneol after pulverization process, giant salamander, polygonum cuspidate, radix scutellariae powder diameter be 140 mesh or more.
9. preparation method according to claim 3, which is characterized in that when being sealed of pasty masses of gained in step 2)
Between be 9-12 weeks.
10. a kind of purposes of ointment as claimed in claim 1 or 2 in the drug of preparation treatment scald.
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| CN101002834A (en) * | 2006-01-19 | 2007-07-25 | 上海玉森新药开发有限公司 | Traditional Chinese medicine composition for treating burns and scald |
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| Title |
|---|
| 大鲵不同部位制备物治疗烫伤与冻伤作用研究;万军梅等;《医药导报》;20130531;第32卷(第5期);第603-604页 |
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Granted publication date: 20190412 Termination date: 20211029 |