TW200942270A - Chinese medicine composition for treatment of wounds or bedsore, and method for producing preparation thereof - Google Patents

Abstract

This invention provides a Chinese medicine composition and a topical paste-like preparation for use in the treatment of bedsore or intractable wounds due to trauma or diseases. Namely, the present invention provides a topical Chinese medicine composition for use in the treatment of traumatic wounds or bedsores, comprising Chinese medicines such as dried ginger, Aconiti Lateralis Preparata Radix(Fu zi or baked Fu Zi), cinnamomum(Cassia cinnamon) etc. as active ingredients. The preferred formulation thereof; in addition to the above ingredients, further contains Bunge pricklyash Peel, or together with Fructus Evodiae, or additionally together with Paeoniae radix and Cortex Magnoliae Offininalis, or further together with Olibanum, Myrrha, or furthermore together with Catechu. Another preferred formulation for the topical Chinese medicine compostion further contains lyophilized mycelia extract of Flammulina velutipes in addition to the aforesaid ingredients. The topical Chinese medicine compostion according to the present invention is an ointment preparation prepared by pulverizing the Chinese medicines in the above formulation and mixing the pulverized medicines with fat (for example, lard) with stirring to form a paste.

Description

200942270 * VI. Description of the invention: [Technical field to which the invention pertains] The present invention relates to a composition of a traditional Chinese medicine. The present invention is further directed to a cream formulation for treating acne and other wounds that are difficult to heal due to trauma or disease. [Prior Art] Acne is a common symptom in clinical medicine, and it occurs in patients who have mobility problems and are sick in bed for many years. The cause of acne is due to the long-term phase pressure of the local skin and the soft tissue of the lower jaw, which results in necrosis of the tissue. The causes of acne are described below: Local factors: 1. Vertical pressure of the epidermis: When the external pressure is greater than the microvascular blood pressure in the local subcutaneous tissue, the local blood circulation is hindered, leaving the cells in an oxygen-deficient state. If the hypoxic state persists for too long, the cells will die and cause skin, or subcutaneous tissue and muscle ulceration. The most oppressed areas are often the most prominent parts of the body's bones, such as sacral bones, body bones, ischial ridges, heels, athlete's foot, shoulder blades and hand wealth. 2. Shear stress of the epidermis: When the patient is lying or sitting, the skin of the sacrum is tightened to produce a horizontal shear force, which exerts pressure on the blood vessels of the ancient skin, resulting in hypoxia and necrosis of the skin. , ', ' 3. Local trauma and infection: In the case of inadvertent abrasion or contusion, the infection will be reduced. If the bed is in bed for a long time, hemorrhoids will occur due to pressure and shear stress. . 4. Local temperature: Due to the decrease of the temperature of the local tissue, the cell metabolic rate drops 320866 4 200942270 and the financial tolerance to hypoxia is reduced. • 5. Local humidity • When the skin is excessively infiltrated, the tissue will be soft and fragile. Poor local ventilation and frequent diapers due to incontinence will make the part often warm. Systemic factors: 1. Age: The skin loses its elasticity and blood circulation deteriorates due to aging, thus reducing the tolerance of the group to hypoxia. 2. s Poor nutrition. Due to long-term malnutrition, tissue repair stagnation, tolerance to hypoxia, and resistance to infection. 3. Anemia. When anemia occurs, the ability of the blood to deliver oxygen is reduced, and when the blood circulation is hindered, it is likely to cause hypoxia in the tissue. 4. Psychological factors: The long-term illness in bed causes the will to survive, and the immunity is reduced. From the point of view of traditional Chinese medicine, the pathogenesis of the disease can be explained by the Yellow Emperor's "Lingshu. 瘫疽篇" (Non-Patent Document 1): 〇 "The cold sorcerer is crying in the meridian, the blood is crying, If you don't get it, then you can't revert it, so it's swollen. The cold gas is turned into heat, the hot is the carrion, the meat rot is the pus, the pus does not diarrhea, the ribs are broken, the gluten is broken, the bone is injured, the bone is damaged, the bones are empty, the blood is empty, and the bones are empty. The muscles are not honorable, the meridians are lost, and they are smoked in the five internal organs. At present, most of the drugs commonly used to treat wounds are iodine preparations, dressings, traumas, burns or ointments, and the effects of these ointments and external preparations are mostly sterilized. However, as mentioned above, the cause of acne and the cause of simple trauma are greatly different between 320866 and 200942270 k. - For the treatment of wounds that are difficult to heal, such as acne, the drug that can simultaneously have the following functions: clearance of bacterial infection, regeneration of necrotic tissue, and improvement of wound healing caused by other diseases has not yet been developed. Effective method of distribution. For the treatment of acne and traumatic Chinese medicine, the following documents are available: (1) Surgical treatment of the whole life collection (Non-Patent Document 2), (2) Surgical authenticity (Non-Patent Document 3), 〇 (3) Medical Archives Patent Document 4). In the literature above, (1) the literature mentions the treatment of ulceration, pubic lice, and frostbite by Yanghe Jiegel. (2) The literature mentions that the pus can be formed in the sores of the sputum, the back of the hair (back mass), various ulcers, rods and the like by the myogenic jade red cream, and can be treated at the time of pus. (3) The literature refers to methods for treating sputum based on sputum. After examining the Chinese medicine formula mentioned in the literature, it is not biased by theory, but U is the actual curative effect, and most patients have treated the wound with iodine and other external disinfectant and other drugs, and increased medical treatment. The difficulty. [Non-Patent Document 1]: "Lingshu.." in the Yellow Emperor's Internal Classics [Non-Patent Document 2]: Surgical Treatment of the Whole Set [Non-Patent Document 3]: Surgical Orthodox [Non-Patent Document 4]: Medical Zong Jinjian [Invention content] As mentioned above, from the perspective of syndrome differentiation and treatment, hemorrhoids can be regarded as a cold syndrome, deficiency syndrome, labor syndrome, phlegm syndrome, blood stasis, and therefore the rule of law is that the cold is warm and the virtual is supplemented by 6 320866 200942270 The laborer Wen Zhizhi, the ruler who took Yangming alone, and then the method of activating blood and removing blood stasis, the Qing Dynasty Qiantang Wu Shiji wrote "The Key to the Law": "The law of internal treatment is the law of external treatment." Consistent. The present inventors have devoted themselves to the development of an effective ointment for treating sores in accordance with the above principles. The invention relates to a composition for treating trauma, acne, and a medicinal ointment for treating trauma and acne, which are characterized by the following items [1:] to ^ and [33]. ❹ [1] A traditional Chinese medicine composition for treating trauma or acne, which comprises: a dry amount, an aconite (or an aconite), and cinnamon as an active ingredient. In the present invention, salt aconite, processing aconite, etc. may be used instead of the aconite which has been attenuated by the attachment. 3 [2] The composition of a traditional Chinese medicine for treating trauma or acne according to [1], wherein, as an active ingredient Dry 4, time (or _ child) and _ mix weight ratio 4 : 2 . 1 〇❹ [3] such as [1] rainbow 2] of the trauma or booty each effective into a flour. (10) A traditional Chinese medicine ointment with 1 bruise or acne, which is characterized by containing [[5] a treatment; a finished product and an appropriate amount of a fat agent. Dried vines, aconites (or =, with the wide range of meat ^ [6] such as [5] treatment of the outsole and pepper as an active ingredient. The active ingredients of the cognac, attached or use of traditional Chinese medicine composition, of which the ratio is 4 : 1 : 1 , 5 inch ) , mixed with cinnamon and scallions * 1 〇 320866 7 200942270 Traditional Chinese medicine composition , [7] such as [5] or [6] for the treatment of trauma or acne with active ingredients Powdery. Treatment = Chinese medicine (4), which is to be levied as: Containing any of the Chinese herbal medicines of [5] to [7" and suitable [9] A treatment for trauma or hemorrhoids, surnamed outside. It is characterized by containing a quantity, an aconite (or an aconite), a cinnamon, a pepper and an anthraquinone as an active ingredient. [10] The composition of traditional Chinese medicine for treating trauma or acne according to (8), wherein the weight ratio of cognac, aconite (or _), cinnamon, and Wu Laixiao as an active ingredient is 4:1 : 1 : 1 : i. [11] A composition for treating trauma or acne according to [9] or [1G], wherein each active ingredient is in the form of a powder. [12] A traditional Chinese medicine for treating trauma or acne (4), which comprises the composition of a traditional Chinese medicine according to any one of [9] to [1.1] and an appropriate amount of a fainting agent. [13] A traditional Chinese medicine composition for treating trauma or acne, which is characterized in that it contains Q, dried dong, aconite (or medicinal aconite), cinnamon, peony, peony and peony as active ingredients. [14] The composition of traditional Chinese medicine for treating trauma or acne according to [13], wherein the weight ratio of dried ginger, aconite (or artillery aconite), cinnamon, peony, sage and peony as an active ingredient is 4:1: 1 : 1 : 1 : Hey. [15] The composition of a traditional Chinese medicine for treating trauma or acne according to [13] or [14], wherein each active ingredient is in the form of a powder. [16] A traditional Chinese medicine ointment for treating trauma or acne, which comprises the composition of the Chinese medicine according to any one of [13] to [15] and an appropriate amount of the oil agent. 8 320866 200942270 • [ 17 ] A traditional Chinese medicine composition for the treatment of trauma or hemorrhoids, characterized by: - with ginger, aconite (or medicinal aconite), cinnamon, peony, peony, peony and magnolia as active ingredients. [18] The composition of traditional Chinese medicine for treating trauma or hemorrhoids according to [17], wherein the weight ratio of dried ginger, aconite (or medicinal aconite), cinnamon, peony, peony, peony and magnolia as an active ingredient is 4 : 1 : 1 : 1 : 1 : 1 : 1. [19] The composition of a traditional Chinese medicine for treating trauma or acne according to [17] or [18], wherein each active ingredient is in the form of a powder. 〇 [20] A traditional Chinese medicine ointment for treating trauma or acne, characterized in that it comprises a composition of a traditional Chinese medicine according to any one of [17] to [19] and a lubricating agent for winding. [21] A traditional Chinese medicine composition for treating trauma or acne, which is characterized by containing ginger, aconite (or aconite), cinnamon, peony, peony, peony, magnolia, frankincense and myrrh as active ingredients. [22] The composition of a traditional Chinese medicine for treating trauma or acne according to [21], wherein, as an active ingredient, dried ginger, aconite (or aconite), cinnamon, amaranth, scorpion, scorpion, peony, magnolia, frankincense and The weight ratio of myrrh is 4:1 : 1:1 : 1 : 1 : 1 ; 1 〇 [23] such as [21] or [22] for the treatment of trauma or acne with traditional Chinese medicine composition, wherein each active ingredient It is powdery. [24]---------------------------------- , its special: for: There are dried ginger aconite (or gun aconite), cinnamon, pepper, the more koji, frankincense, myrrh and catechu as an active ingredient. I and Le 320866 9 200942270 • [26] [25] for the treatment of trauma or acne with Chinese medicine composition, which, for the sake of the coincidence *, aconite (or gun time), Lai, _, Wu Hao, The weight ratio of peony, magnolia, frankincense, myrrh and catechu is 4: !: 1 : 1 : 1 : 1 : 1 : 1 small [27] such as [25] or [26] for the treatment of trauma or hemorrhoids The composition of the traditional Chinese medicine, wherein 'the active ingredients are in the form of powder. [28] A traditional Chinese medicine ointment for trauma or hemorrhoids, characterized by containing a composition of Chinese medicine [27] and an appropriate amount of oil agent. 〇[29] such as [1] to [3], [5] to [7], [9: U [11], [13 to (10), to (10), [25] to [27] A composition for treating trauma or sore, which additionally contains a strain of Mycelium of Mycelium as an active ingredient. [30] Such as [29] for the treatment of trauma or hemorrhoids with traditional Chinese medicine composition, of which, the content of the extract of A. sinensis mycelium, relative to other active ingredients of dried ginger, aconite (or artemisia), cinnamon, The total content of the pepper, the medicinal herbs, the medicinal herbs, the thick sage, the frankincense, the myrrh, and the catechu is 1 part by weight, preferably 0 〇1 to 0.27 parts by weight, preferably 0. 02 parts by weight. ♦ [31] For example, [29] or [3G] is a traditional Chinese medicine composition for treating trauma or acne, wherein the active ingredient is powder. [32] The invention relates to a medicine for treating trauma or acne, which is characterized in that the composition of the traditional Chinese medicine of any one of (4) to [31] and an appropriate amount of the oil agent are contained. [33] A composition or ointment for treating trauma or acne according to any one of (4), [8], [12], (10), (10), (10), _, wherein the oil agent is lard. 320866 10 200942270 This month's treatment of trauma, acne with traditional Chinese medicine composition, and the treatment of traumatic acne with ointment, its main effects include: increase the patient's immunity '" is also "righteous"; not only effective Controlling the infection can also go to the saprophytic muscles, which means that the cockroaches are "to make the new and new, and compatible with the wound and quickly absorb the exudate" and keep it moist. The present invention provides a topical Chinese medicine ointment suitable for treating a wound healing condition. The external Chinese medicine ointment of the present invention is most effective in treating acne. Ben, Mingzhong Chinese medicine ointment contains dried ginger, aconite (or medicinal aconite), cinnamon, peony pepper Wu Chuchu, medicine, magnolia, frankincense, myrrh and catechu and other Chinese herbal medicines. The effect is better when it is added to the A. faecalis mycelium extract. Dried ginger is a dried product of the root of ginger ginger. It has the effects of warming and dispelling cold, stopping bleeding, and returning to the yang, and has pharmacological effects of analgesia, anti-hypoxia and anti-inflammatory. The aconite is the lateral root (sub-root) of the Aconitum Uconii (10) 0 (3). It has the effect of returning to the sun, reversing the cold and dehumidifying, and has the pharmacological effect of enhancing the immune function of anti-myocardial ischemia and hypoxia, anti-thrombosis and anti-inflammatory to increase the lymphocyte transformation rate. The aconite attached to the aconite is attenuated. Cinnamon is a tree of the genus Cinnamomum (10) (10) (2) a presi, and is a dry processing processor. It has the effect of supplementing the fire and helping the yang, dispelling cold and relieving pain, and warming the blood circulation. The anti-cancer, anti-inflammatory, anti-bacterial and anti-aging pharmacological effects. Cinnamon can also be used for cassia twigs. [Embodiment] 11 320866 200942270 The following is a preferred formulation selected from the above traditional Chinese medicines, wherein the numerical value indicates parts by weight ° Formula 1 is: dried ginger 4, aconite (or artillery aconite) 2, cinnamon b Formulation 1, for: dried ginger 4, aconite (or gun aconite) 2, mycorrhizal mycelium extract 0. 27.虫可ο 卜 Formula 2 is: dried ginger 4, aconite (or gun aconite), cinnamon, chopped pepper, formula 2':: 砮望 / 金金菌菌菌提取物^ or gun aconite) 3 is ·········1, Wu茱萸1. Aconite (or gun aconite) 丨, cinnamon, 蜀 pepper Formula 3': 参曾 / 1, Wu 茱萸 金 金 金 诘 诘 ( ( 或 或 或 或 或 或 或 或 或 或 或 或 或 或 或 或 * * * * * * * * * * * * * * * * * * * * * Recipe 4 is ······················· Aconite (or Aconite M, Cinnamon Bud: Formula 4' is ···················································· Mycelium extract 0.27.. 1. Wusong 1μ aconite (or gun aconite M, cinnamon 1, _, spoon Le Houpu 1. Formula 5 is: λ λ i, Wu 茱萸 b 4 (or gun aconite) Cinnamon 1, _ Formulation β is: Mycelium of Mycorrhiza sinensis mycelium extract. 27. Bu Wuzhen 1, 4 plant aconite (or gun aconite) Bu Cinnamon Bucchi formula 6, for Magnolia, such as ^ B, aconite ( Or gun aconite) Bu Cinnamon 1, Bell Pepper 320866 12 200942270 1 Xing Yi, the medicinal medicine Bu Houpu Bu milk fragrant sputum, myrrh] « Mycelium extract 0. 27. ι needle #菌,本(四)中药(四)' scale The above-mentioned Chinese medicinal materials are mixed and ground into powder after the above-mentioned mixing, and then added with an auxiliary agent and stirred. ° The above Chinese medicinal materials can be fresh or dry. However, it is preferable to use a dry type. The degree of quality sound is not particularly limited, but when it is excessively dried, it will affect the minerals or animal and plant fats. Also = oil: in addition to the soil, Vaseline, such as the petroleum resources from the number of carbon atoms more than 15 stone publication animal oils, such as _ ^ 糸歹 ° butter, Shao oil, cod liver oil, The deep sea oyster sauce, etc. '5' can be exemplified as egg 0; for animal fat, for example, botanical oil deer such as butter, lard, and sheep oil, in terms of vegetable oil, it can be mentioned as: Oil; semi-drying oil such as sesame oil; 撖·Kinghua oil, in terms of vegetable fat, can be listed as a non-drying oil. In the present invention, such coconut oil, woody soil, etc. Mineral oils and fats are Vaseline horse light- Preferably, the oil is preferred. The animal and vegetable fats and oils are used for the use of butter, pig, and the external plaster of the traditional Chinese medicine according to the present invention, and may be used as a fat or emulsion material. The experiment of human has confirmed that the effect of shell lard is the best. 320866 13 200942270 _ The above auxiliary agent (such as lard) is mixed with the above-mentioned ground powdered Chinese medicine preparation and stirred to prepare an ointment and the like. Viscosity, can be mixed with Z appropriate viscosity modifier In addition, in order to make the user easy to accept, a suitable deodorant or fragrance may be incorporated. The above-mentioned mycelium extract of Flammulina velutipes may be added simultaneously with the adjuvant after the above-mentioned Chinese medicine is ground into a powder. The mixture of the above-mentioned cream preparations is added, and the above-mentioned mycelium extract of Flammulina velutipes is added and stirred and mixed. : ' ◎ The scope of the plaster of the present invention covers: skin (skin), vein (neural) , blood vessels, meridians>, meat (subcutaneous fat), tendons (muscles), bones (bone marrow), etc. The paste preparation of the present invention has the following advantages: • Effect on deep ulceration: > The most difficult place for acne treatment It is the removal of necrotic tissue (this is the so-called "shadow" of traditional Chinese medicine), and the plaster of the present invention has the effect of relieving cold and condensing, so it can kill the muscle and terminate the ulceration. This is the key to whether it has curative effect. . Promoting the regeneration of granulation tissue (graniQati〇n tissue): The plaster of the present invention has the effect of promoting the formation of new muscles. • Inhibition of exudate: A large amount of exudfe (exudafe), which is a yellow sore (transfective purulent acne), whose pathogens are mostly Staphylococcus aureus. The active ingredient contained in the plaster of the invention has the function of enhancing the phagocytosis of the swallowing cells and improving the immune function of the body, and has an inhibitory effect on various pathogens. 1 • Maintaining a wet state: The plaster of the present invention has an inhibitory effect on the infiltrates of the above exudate, and at the same time, the tissue excreted by the exudate is kept moist to facilitate recovery of the wound. The plaster of the present invention is applicable at each stage of the above-mentioned acne. Next, a method of producing the above-mentioned extract of Mycorrhiza mycelium mycelium will be described. First, the solid medium made of bagasse is mixed with water, preferably pure water, and then sterilized and cooled. Then, the golden needle garlic is inoculated (the inoculum. In addition to the rice bran in the bagasse medium, phosphorus may be added as needed. Minerals such as iron; the skin of peanuts, sugar rice, etc. The S-slag after the juice is extracted from the nutrient-glycoside and protein of g-filament, which can be directly used as a solid medium, but when the above-mentioned rice bran is added For 80 parts by weight of the crucible, usually 1 to 20 parts by weight of rice sugar is added. The Flammulina velutipes can be used by a well-known person. Then, after the inoculation of the golden needle is difficult, the riding base is moved to the warm production. The temperature, the degree of illumination and the illuminance are also adjusted in the culture room, so that the bacteria _= If the Flammulina velutipes breeding period is proliferating, inoculation of Flammulina velutipes. The temperature and the degree of fishing should be determined under the conditions of temperature 14 to the order and the degree of seating exceeding the prevailing conditions. Under the conditions of 75 to (4), it is best to culture in a culture room under the condition of 80 to 95% of the upper culture. The culture is usually between 2 and 6 months, preferably between 2 and 3 months. Continued time between the door, expectation 320866 15 200942270 bacteria Body proliferation. Due to the action of Flammulina velutipes, the medium is decomposed into water and carbon dioxide, and the internal moisture of the medium is the most. If the temperature is set to 7 ^ ^ :, the result will be the medium. Shrinking, but not able to make a fortune

The Q entity is about to produce the substrate in the previous period, and it is better to pass the 12m _ part of the unwinding surface. Also, the _ ship base medium ^ is 30 weight (four) produced before and after the period, but it can also be carried out in the child 俨: in the fruiting body. In the period of "the period of considerable growth, the solid medium is added to the medium of 3 〇 to 5π ° γ · τ γ, and more than one kind selected from water and fiber" = glucosidase, hemicellulase, Several enzymes, ',, '', protease, and grape enzymes. The enzyme added by chymase, amylase and pectinase should be cellulase. Unconstrained = two: = 2: 2 subclass The pure water 'in the & is added to become the age of the skin. 41 to 1Qkg' is preferably 3 to ring, and then, the mixture containing the residue containing slag. If it is extracted from the mycelium of A. niger, it is preferable to be two; = 320866 16 200942270 - The mixture is circulated using gears such as a gearbox, and comminuted and collapsed in a solid medium to allow approximately 70% by weight of the bagasse fibers to pass through a 12 mesh screen. When the amount of the 12 l Qesh mesh sieve is less than 70% by weight, the extraction of the active ingredient in the solid medium is insufficient, and the portion of the cellulose which is not sufficiently softened is increased, and the obtained solid residue cannot be fully and effectively utilized as feed, foodstuff or Fertilizer. Containing bagasse The pulverization or mashing of the mixture can be carried out at a temperature at which the mixture is maintained at 30 to 50 ° C, or at a temperature at which the temperature starts to rise slowly, preferably while the temperature is rising. The water temperature is maintained at 30 ° C or higher, preferably 3.5 ° C or higher. At this time, when the room temperature air is sprayed with the mixture containing the New Zealand, the air bubbles are broken by being rapidly twisted, and the bagasse fibers are impacted. Effectively promote the 'extraction of the active ingredient: take. Then, if the treated bagasse-containing mixture is further heated to 0 to 95 ° C, it is preferably heated to a temperature of 75 to 90 tl · to maintain the temperature for tens of minutes The enzyme in the mixture is inactivated and the mixture is sterilized to obtain the mycelium extract of Flammulina velutipes. If the enzyme in the mixture is heated to inactivate and sterilize, the mycelium of Flammulina velutipes is prevented. Deterioration of the extract. The mycelium extract of Flammulina velutipes can also be used as a filter cloth of 50 to 120 halls h, preferably 6 to 1 〇〇mesh, as needed. Silk body extraction Contains a new anti-tumor component; pr〇flamin). 320866 17 200942270 This extract can be used after concentration, or can be freeze-dried into a powder for use, or further diluted with, for example, purified water, alcohol, etc. It is added to pharmaceuticals (for example, atopic dermatitis therapeutic agents, antifungal agents, vesicle therapeutic agents, immunostimulating agents, AIDS therapeutic agents, carcinostatic agents, etc.) and cosmetics (skin moisturizing cosmetics, etc.). The composition for treating trauma, acne, and the intermediate medicine for treating trauma and acne according to the present invention will be more specifically described by way of production examples and examples. 〇Production Example 1: After the following Chinese medicinal materials are formulated according to the following formula, Mixing, pulverizing, and evenly stirring: 150 g of dried ginger, aconite (or medicinal aconite) 37. 5 g, cinnamon 37. 5 g, 蜀 pepper 37. 5 g, 茱萸 茱萸 37. 5 g, peony 37. 5 g, magnolia 37 · 5 g, frankincense 37克。 (5. 5g, 487. 5g). The grinding system was carried out using a gas flow type ultrafine pulverization Q machine (Taiwan Patent No. 121630) manufactured by Xinzhen Enterprise Co., Ltd., and was ground to a degree that it could pass through a mesh of 120 mesh (fine pulverization). After pulverization, it was mixed with 2400 g of lard and stirred into a paste to prepare an ointment preparation (Chinese Herbal Ointment 1: 2887. 5g). Production Example 2: According to the same prescription as in the above Production Example 1, the prepared Chinese herbal medicine (total 487.5 g) was mixed and pulverized into powder, and the freeze-dried Flammulina velutipes mycelium extract powder was added. g, and evenly stirred, and then mixed with 24 〇〇g lard to form a paste, and the ointment preparation (Chinese medicine ointment 2: 2897. 5g) 〇320866 18 200942270 贞 贞 贞 培养 培养 培养 培养Υ. Μ)<Preparation method: • After a suitable amount of pure water is composed of 90 parts by weight of bagasse and 1 part by weight of rice bran, the inoculum is inoculated with Flammulina velutipes (foot reJ elbipe). Adjust the temperature and humidity in the culture chamber to make the mycelium multiply. After the mycelium propagated in the medium, the cellulose of the bagasse substrate was unwound, and the portion passing through the mesh of 12 mesh was 24% by weight or less. To the 1.0 kg medium which was unwound, 3.5 kg of pure water was added, and 2 〇g of cellulase was added while maintaining the temperature at 40 ° C to obtain a mixture containing the medium. Then, the mixture containing the medium is circulated and crushed in the gear portion for about 200 minutes in a cycle of the gear pump 2 with the shifting device, so that the solid medium has about 8Q% by weight of the bagasse fibers passing through the 12 mesh. Mesh screen. The pulverization and mashing of the mixture containing the medium is carried out under the condition that the temperature of the mixture 4 is gradually increased. 0 The mixture containing the medium was then heated and incubated for 30 minutes. The enzyme is deactivated by the heating of the machine and sterilized into a current == cultivating mixture, and the mixture is pulverized by 6 〇 ^ _ into the mycelium mycelium extract, after being contracted, to the golden needle garlic The mycelium extract is cold-dried dry powder 6', 'Mingzhi I ^ «r-ι ' (F. V· M) and used by you f : (= using gold needle __ body culture extract (therapeutic agent) As a result of reviewing the silk effect, it was found that the new muscle was produced compared to the mycelium extracting name 320866 19 200942270, and the mycelium-containing mycelium culture extract (FVM) of the present invention was used. The acne treatment agent will promote the formation of new muscles. Under the effect of the anti-tumor effect, immune activation and anti-fatigue effect of the gold needle 4 reading 囷 silk body culture extract (FVM), It can improve the body's resistance. Especially the low concentration of Flammulina velutipes mycelium extract can eliminate fatigue by stimulating the sympathetic nerve. ◎ (2) Acne preparation containing Flammulina mycelium mycelium culture extract (F·VM) (Example: Manufacturing Example 2 Chinese Medicine Ointment 2) has Flammulina velutipes The silk culture extract (F·V. M) itself has anti-tumor effect, immune activation and fatigue elimination. Furthermore, the Flammulina mycelium culture extract (F. vj|) has moisturizing effect on the skin. The action 'promotes the new muscle formation of the skin through the use of the acne treatment agent' to form a new muscle in advance due to the moisturizing effect. The present invention contains the Flammulina mycelium mycelium culture extract (F. vm) 2 Acne therapeutic agent (ie, traditional Chinese medicine ointment or traditional Chinese medicine ointment 2) (none), in promoting the therapeutic effect on wounded skin, relative to (b) untreated (when the wounded skin is not treated), in the wound The tensile strength after healing exhibits a high value and promotes healing. The Chinese medicine ointment 2 of the present invention is compared with the "b-FGF" (acne treatment agent) which is a commercially available acne therapeutic agent. , research and pharmaceutical (stock) manufacturing; commonly known as "trafermin"), showing a strong and effective healing effect, excellent healing effect on skin wounds (test case H). Diabetic mice (db/db mice) formed a wound on the back 20 320866 200942270 - After applying the traditional Chinese medicine ointment 2 on the wounded area, the area of the wound was determined, and the result was that the Chinese medicine ointment 2 promoted healing. Moreover, the area under the curve of the area of the wound site opposite to the time (A[JC: the under curve of the anus) also showed a significant low value' judgment with the use of =a (Test Example 12). The plaster is used according to the following instructions. First, the therapeutic mouth is cleaned with a sterile physiological saline solution. The Jiang Ting medicine is applied to the non-woven fabric and covered with gauze, and then the shouting = stick will paste the cream and the deeper. (According to the sore mouth * on the treatment mouth. Apply the amount to the sore mouth and apply gauze. Daily, small, deep, and several times. Care must be taken when changing the dressing. Do not make the wound (when the condition of the wound is changed, keep it moist, avoid iodine disinfection.) New film rupture, the same preservation method: must be placed in a cool place,; when the sun is straight, please put it in the refrigerator, save it effectively, sputum irradiation, long-term storage [Example] ^ limited to one year. 0 Experimental example, 1; Medical record 1: Chen Wei, 52 years old, for cerebral hemorrhage on September 28, found that there is hemorrhoids in the recommendation department, the injury tube 'long-term bed rest 1 2〇〇7 ulcer invasion to the dermis, is the ugly degree of hemorrhoids (area) about 10cmx5cm The wound of the hemorrhoids of the manufacturing case 1 was healed on the 1st day. If it is replaced on the first day, it will be as shown in the next year, October 2: Figure (A) to (8). Medical record 2, Zhao X, 66 years old, There are hemorrhoids in the brain, and the wound is about 3cmx2. The 'long-term bed' recommendation to the subcutaneous fat layer is a m degree 褥320S66 21 200942270 ' Sore, the disease has been cured for 1 month, the wound healing is poor, September 29, 2007, used to manufacture In the case of the hemorrhoids cream of Example 1, the wound healed well on October 10 of the same year. 2 Figures (A) to (D). Experimental Example 3: Medical record 3, Zheng X, 34 years old, patient with hypertension, lower extremity venous thrombosis, May 5, 2007, came to the hospital for treatment, left heel due to trauma Causes cellulitis, the disease has been 1 month, the wound to the subcutaneous fat layer, the wound is about 10cmx4cm ° @ Use the hemorrhoids ointment made in Manufacturing Example 1, change the dressing once a day, the wound has healed on July 20 of the same year. 3 (A) and (B). Experimental Example 4: Medical record 4, Wang X, 21 years old, in the beginning of March 2007, the right calf was injured due to a car accident, and the wound healing was poor after the healing, which caused cellulitis. The wound is about 6cmx4cm, and the wound is to the muscle layer, which is a grade IV hemorrhoid. The same year, from the 12th of the same year, the hemorrhoids cream of the manufacturing example 1 was used, and the wound was healed once a day until the wound on June 29 of the same year. As shown in Fig. 4 Experimental Example 5: Medical record 5, Peng X, 54 years old, for cerebral hemorrhage and diabetes, long-term bed rest, hip sore, wound to muscle layer, wound about 10cmx5cm, is a grade IV hemorrhoid. Hemorrhoids on the back, wound to the skin Fat, wound about 5cmx3cm, belongs to] hemorrhoids, the course of disease has been 2 months. 20 Since June 2007, the hemorrhoids cream of the manufacturing example 1 was used, and each time the sputum was replaced, the wound was healed on July 17, the same year, as shown in Fig. 5 (A) and (B) 22 320866 200942270 - Example 6 : Medical record 6, X, 76 years old, inconvenient to move, long-term wheelchair, trampoline, back hemorrhoids, red skin and skin, wound to the epidermis, is a degree of hemorrhoids, the disease has been 1 month, October 2007 The hemorrhoid ointment of the manufacturing example 1 was used from the 1st, and was changed once a day until the wound was healed on October 7 of the same year. As shown in Figure 6 (A) to (E). Experimental example 7 Bu 病 Medical record 7, Liu X, 64 years old, for breast cancer and rectal cancer patients, small intestine artificial anal stoma, multiple wound healing in the abdomen, suppuration. The wound to the dermis, mostly 1 to 2 cm x 1 to 2 cm, is a acne acne, and the course of disease has been several months. Since September 2007, the hemorrhoids cream of the manufacturing example 1 was used for treatment. On October 5 of the same year, the suppuration was stopped and the wound was healed. As shown in Figure 7 (A) to (F). Experimental Example 8: q Medical record 8, X, 79 years old, is a diabetic patient, the left thumb is black and necrotic, the second toe joint is red and swollen, and the course of disease has been several months. In July 2007, the hemorrhoids ointment of the manufacturing example 1 was used, and the daily replacement was performed 1 to 2 times, and on August 3 of the same year, the purulent redness was improved. As shown in Figure 8. Experimental Example 9: Medical record 9, Wei X, 76 years old, for patients with cerebral hemorrhage, long-term hop bed, hemorrhoids in the ischial bone, wound to the dermis, wound about 2cmx2cm, the course of disease has been 1 month, from August 10, 2007 The hemorrhoids of the manufacturing example 1 were used for treatment, and the wounds healed on September 21 of the same year. 23 320866 200942270 'Experimental case ίο: • Medical record 10, Zheng X, 77 years old, is a tuberculosis patient, prolonged bed rest, hemorrhoids on the left shoulder, redness and swelling of the skin. The wound to the epidermis, the wound is about 2cmx2cm, it is a degree of acne, and the course of disease has been 2 months. The hemorrhoids cream of the manufacturing example 1 was used from July 13, 2007 to the wound healing in the early August of the same year. Experimental Example 11: Treatment experiment of the cream of the skin of the rat 2 in the rat skin: 1. Summary of the 12-week-old Crl: CD (SD) rat skin wound model The obtained traditional Chinese medicine ointment (also referred to as "Chinese medicine ointment 2") is treated to promote healing. The results are shown in Table 1 and Figure 9 below. (A) Untreated group, (B) Chinese medicine of the present invention The average value of the tension strength after wound healing of the ointment 2 treatment group and (c) "b-FGF" (acne treatment agent, scientific research pharmaceutical (share); commonly known as "trafermin") treatment group is (曱) ) 143 ± 8g, (B) 289 ± 31g, (C) 2 〇 5 ± 1 such as. Compared with (a) untreated group, (b) the Chinese medicine ointment 2 in the present invention and (4) the "b-FGF" treatment group had an increase rate of tensile strength after wound healing of 102.1% and 43.4%, respectively.

The treatment group of the Chinese medicine ointment 2 of the present invention and the treatment group of "Bu FGF" (a acne treatment agent, a scientific research pharmaceutical (share), commonly known as "trafermin") treatment group: the tensile strength after wound healing, compared with the untreated group, Significant ancient values are presented, suggesting a promoting healing effect. It is also known that the "b_FGF group" of the present invention is more effective in promoting the treatment of skin wounds (see Table 1, Figure 9). From the above results, the present invention obtained in Production Example 2 The Chinese medicine ointment (Ointment 2) disposal group presents the promotion of Bu Qing beyond the commercially available acne treatment agent

The soy cream can be used to embody the excellent effect of skin ointment 2 of the present invention on skin creation. J The following is described in detail in conjunction with the experimental procedure. 2·&lt;Experimental Summary&gt; Inventive Herbal Ointment (i) (i-a) Test substance: The original product obtained in Production Example 2 (Wool soft I* 2). (Qiao) Comparative control substance: "FiMast (registered trademark) plus 叩 」" (abbreviated as "b-FGF"; acne treatment agent, research and pharmaceutical (stock) manufacturing; commonly known as "trafermin"). (ii) Experimental system: rat (SPF), Crl: CDCSD). (ill) Experiment: For the promotion of the Chinese medicine ointment (Chinese medicine ointment 2) of the present invention by the production example 2, the experiment was carried out using the money skin cut model. (iv) Experimental period = February 26, 2008 to June 2008 (v) Experimental implementation day: Animals (rats) were obtained and grouped, after the cuts were made (the next day of March 2008) The drug was administered on March 17, 20, 2008, and it was not until March 20, 2008. Tension measurement was conducted on March 21, 2008. (VI) The first day of the animal (rat) obtained (the day of acquisition) was in the range of 325 g to 403 g. There was no abnormality in the general state and weight change of the animals obtained during quarantine and domestication. 320866 25 200942270 ' (vii) Humidity: Raised at a humidity of 40. 0 to 70. 0% (although it is outside the range in a very short time, it does not affect the experimental results). 3. Preface The experiment was carried out using the skin cut model of a 12-week-old Crl:CD (SD) rat to promote the healing effect of the traditional Chinese medicine ointment obtained in Example 2. 4. <Subject substance, etc.> 4. (a) Test substance and comparative control substance Test substance: The traditional Chinese medicine ointment (Chinese medicine ointment ❸ 2) of the present invention was obtained. Comparative control substance: "Fiblast (registered trademark) Spray 250" (abbreviated as "b-FGF"; 褥 治疗 therapeutic agent' research and pharmaceutical (stock) manufacturing; commonly known as "trafermin"; batch number: G71183). 5. <Publication of the specimen> 5. 1 (a) Modulation method (Comparative substance for comparison) ❹ Test substance: It is used directly in the experiment. The comparative control substance was dissolved in the total amount of the solution (2.5 mL/branch) attached to the bottle (250 #g) to a concentration of 〇, 01 w/v/%. 6. <Testing System> (6-1) Experimental animals and animal species used in pharmacological experiments in the feeding condition experiment, the system maintains a clear male Crl: CD (SD) (SPF; CHARLES RIVER LABORATORIES JAPAN) On March 5, 2008, 42 experimental animals were obtained. 26 320866 200942270 ' The weight range for the day is 325 to 403g. These first set 5 days of inspection 'the epidemic period has another 7 days of domestication. During this period, the body weight was measured three times a day (the electronic balance used: PM2000, PG2002-S; manufactured by Mettler Toledo International Inc.) and the general state of 1 曰1 times. Observed, no abnormalities were observed in the experiment. The animal system maintains a set temperature: 23t: (measured value: 20.5 to 24.7° 〇, set humidity 55% (measured value: 29.4% to 74.9%), 12 hours for light and dark, and 12 times for air exchange/hour ( Breeding fresh air through the filter) Raise in the breeding room. Replace the tray and water bottle twice a week. The feed system will be solid feed (CRF-1; batch number: 0711〇5, Sakamoto Oriental yeast) Industrial (stock) manufacturing) Put it into the feed box to make it free to eat. The beverage water system puts the tap water into the water bottle for free ingestion. (6-2) Grouping method and individual identification method grouping is carried out on the day of administration. After dividing the layers by computer, they were randomly divided into 3 groups by random sampling method, and each group was 1 ,, and the dispersion and average body weight of each group of animals were almost the same. The remaining animals after grouping were killed under anesthesia. 6-3) The route of administration and administration is transdermally administered according to the clinical application route. The administration method is based on the general method used in the experimental equipment, and the test substance (the second one) is a syringe made of polypropylene material. According to the pre-measured specific gravity Apply 20 〇mg (〇.2mL) to the wound site. Use a micropipette to compare the control substance (Group 3) 〇.2mL to the wound site. 27 320866 200942270 Only the number of times of the drug is 1 day for 4 consecutive days. In the morning, the implementation of the 'wound production day and the removal of the Michel suture clips were carried out immediately after the end of the work. (6-4) The composition of the group, the dosage and the use of the animals were only the first group (not implemented) There are 1 处置 ) : : : : : : : : 第 第 第 第 第 第 第 第 第 第 第 第 第 第 第 第 第 第 第 第 第 第 第 第 第 第 第 第 第 第 第 第 第 第 第 第 第 第 第 第 第 第-FGF disposer has 1 ) only): Coated 〇.-. ν 7. <Experimental method> (7-1) Skin cuts are made in a pentabarbital steel (pent〇barbHai Sodium) Salt . "Nembutal" (registered trademark) injection; 4 〇 mg / 〇 8mL / kg, i, P) after anesthesia 'to the back of the animal's hair _ knife back skin with alcohol cotton to eliminate money' material hand red Hat on the city 3 4cm wound (the day is the day of the cut injury). At the center of the cut site and from the central crotch to the head side and tail The lcm position of the side (3 places in total) was sutured with a stapler (Michel staples: large 3·〇xl4mm, manufactured by Natsume Sangyo Co., Ltd.) (7-2) Evaluation of wound healing effect before the fourth day of the cut production Remove the Michel clip under the anesthesia of acetaminophen. Measure on the 5th day of the cut (electronic balance used: PG-2002-G; METTLER TOLEDO), and anesthetize with ether. The skin around the wound is peeled off. A rectangular skin piece (about 2 cm x 3 Cin) centered on the sword wound is prepared, and the skin piece is fixed at a position of 0.5 cm from the side end. The tensile tester for the wound healing test (TK-251) 28 320866 200942270 'Uni com(stock)) Determines the tensile strength after wound healing (required for cut splitting. Load). Further, from the second day to the fifth day of the cut, the general state was observed once a day in the morning. 8. &lt;Comprehensive statistical method and result&gt; The mean value of the tensile strength and body weight after wound healing in each group was determined. The increase rate of the average tensile strength after healing of each group to the untreated group was also determined. Statistical analysis was performed on the comparison of the two groups between the tensile strength after wound healing. That is, the test of equal dispersion is performed by the jr test, and the Aspin-Welch 1: test is performed for the dispersion of inequality. In addition, the comparison between groups (Group 1 vs. Groups 2 to 3) is as follows. The significance level is considered to be less than 5%, and each is expressed as less than 5% (p < 0.05) and less than ι % (ρ < 〇. 〇丨). (comparison between groups) Q Compare the first group to the second to third groups. 9. &lt;Experimental results> A review of the healing effect of the skin cut model made by rats, and the results are not to the tensile strength after untreated wounds in Tables 1 and 9 143 ± 8g. When the skin cut model was treated with the traditional Chinese medicine ointment (Chinese medicine ointment 2) obtained in Production Example 2, the tensile strength after wound healing was 289 ± 31 g, which can be judged that after wound healing, compared with the untreated group The tensile strength is significantly increased. Furthermore, the rate of increase in the strength of the wounds after healing of the wounds of the untreated group was 202.1866 200942270. • The tensile strength after wound healing of the b-FGF group was 2〇5±l9g, and it was concluded that the tensile strength after wound healing was significantly increased compared with the untreated group. Further, the rate of increase in the tensile strength after wound healing in the untreated group was 43.4% &1〇. &lt;Conclusion;&gt; The skin cut model of a 12-week-old Crl:CD (SD) rat was used as the present In the invention, the ointment 2 was subjected to an experiment for promoting healing, and the result was (A) untreated group, (b) the Chinese medicine ointment 2 treatment group of the present invention, and (c) after the wound healing of the "b-FGF" treatment group. The average value and standard error of the tensile strength are (曱) 143±8g, (B) 289±31, and (C) 205±19. With respect to (a) untreated group, (b) the increase rate of the tensile strength after wound healing of the Chinese medicine ointment treatment group obtained in Production Example 2 and the (c) b-FGF treatment group was (B) 1〇2 1% and (C) 43.4%. (b) The traditional Chinese medicine ointment treatment group obtained in Production Example 2 and (c) b_F (JF ◎ treatment group, the tensile strength after wound healing, compared with the (曱) untreated group, showed a significant high value, indicating that there is promotion The effect of healing. Moreover, compared with the (c) b-FGF treatment group, (b) the Chinese medicine ointment treatment group obtained in the production example 2 has an effect of promoting wound healing on the skin. Compared with the b_FGF which is a commercially available acne therapeutic agent, the traditional Chinese medicine ointment of the present invention which was transmitted by the reversed Example 2 exhibited a stronger promoting healing effect, and showed the utility of the traditional Chinese medicine ointment obtained by the production example 2. 320866 30 200942270

I -_ II Table __I ο ac.sponoA.ss-slM^yq'alsuf-cWIXaJOaaanB^^laoaiasl^KiJOO.g.sspomasMnqwJolip^uTr .7032 Music [_|^韧鹚#[#_^^1 V葙(2 and birthday Φ) 蘅碟-403⁄4醵.3⁄4 Weight (g) [Body weight(g)] Final 曰Final day *n -H 9 m •HS 422 ± 4 First 曰Initial day 429 ± 4 430 ± 4 430 ί 4 Think R Ξ ^ % Jg- S 1| 々&gt;1 D Male 1 increase rate (%) lncmuscrrale(4/i) 1 102.1@ 43.4@ um War A ·τι!«ΐ— Actunl value (g) Do -H jj im i 3i *· 205 ± 19 * fil frmVI «Vkvtlmt trt* dose [Dose] _ medicament Drug /-N _ .3⁄4 彰 IW 象# Control slave Cojatroi — 0 1 1 Im i ;5 is 3 mm WGF 02 Φ f\K * lkWI ΩΙ· fiiattSfi^Bnflir fllffikr*.铤^毋灭(10.1-|'Mang 8) degree 3⁄4 broken pull (5 fast-δ3?® 趄 靱 獬逑 « « « « « « « « « « « « * * * * * * * * * * * * * * * * * * * * * * Xlii^—dlolsy per•dno&amp;falmoauqlapu/nhood i {δβικί ρ^βνβ,ϋπτι# 31 320866 200942270 'Experimental Example 12: 'The Chinese herbal medicine ointment 2 for treating mice with hereditary diabetes (db/db Healing effect test of skin wound model of mouse) 1. &lt;Experimental summary> (1-1) Test substance: The traditional Chinese medicine ointment (Chinese medicine ointment 2) obtained in Production Example 2 (b) Mouse (SPF), BKS.Cg-+Leprdb/+Leprdb/Jc: 1. U-3) Experimental purpose: To make a skin wound with hereditary diabetic mice (db/db mice) ^ The experiment of the traditional Chinese medicine ointment of the present invention obtained in Example 2 has a promoting effect on wound healing. (1-4) Experimental period: starting from February 26, 2008 to July 7, 2008. (1-5) Experiment date: First, experimental animals (mice with hereditary diabetes; db/db mice) were obtained, and a wound model was prepared after grouping (April 9, 2008), and then the drug was administered. The contribution of the substance began on April 9th, 2008 and ended on April 29, 2Q08. (1) The weight of the first day of the day of the animal (the day of the acquisition) was 42.0 g to 45.4 g. There was no abnormality in the general state and body weight of the animals obtained during quarantine and domestication. (1-7) 3-methyl-1-butanol (batch number: WKG6715). 2. <Summary> A wound portion was prepared on the back of a 12-week-old mouse (db/db mouse) having hereditary diabetes, and the traditional Chinese medicine ointment (Chinese medicine ointment 2) obtained in Production Example 2 was coated 1 per sputum. Secondly, the area of the wound site was measured once every 2 days, and the effect of promoting the healing of the Chinese medicine ointment 2 was adjusted to 32 320866 200942270. • As a result, it was found that the soft medicine f 2 of the present invention exhibited a significant high value on the third day of administration, and a significant low value on the nth, thirteenth, fifteenth, and seventeenth and the ninth, and thus it was confirmed that there was promotion. The role of healing. Moreover, the area of the wound site to the area under the curve of the elapsed time (weight) also showed a significant low value, and it was judged to have the effect of promoting healing. + "b-FGF" (a manufacturing agent for the treatment of acne, a research and pharmaceutical company); it is called "traferminj", and it is administered on the 9th, u, 13, 15, 17th, 19th and the At 21 days, it showed a significant low value, and Xiamen also showed a significant low value, which was judged to have a promoting healing effect. From the above, it can be seen that the traditional Chinese medicine ointment 2 has the effect of promoting wound healing in the wound of Beishi mice. <Preamble> ^ In the rat back cut test shown in Example 11 (the therapeutic experiment of the Chinese medicine ointment 2 on the rat skin cut model in the present invention), the Chinese medicine Q ointment 2 of the present invention has a wound on the wound Promote the role of healing. 'Moreover, in order to investigate whether there is a wound healing effect, use 12 weeks of "diabetic mouse Wb / db mice" (four) · two, the use of the traditional Chinese medicine on the wound formed on the back The ointment 2 was sealed with a waterproof breathable dressing (Tegaderm), and the area of the wound site was measured twice a day and every 2 days to investigate whether the traditional Chinese medicine ointment 2 has an effect of promoting healing. ' (Note 1) "Chinese medicine ointment 2 is applied in a closed manner with a waterproof and breathable dressing". As described below, the wound site is covered by a method of applying a ventilating sealant to the back of the mouse at 320866 33 200942270. "Tegaderm" (which prevents water or pathogens from entering the wound site and has a passability of water vapor and oxygen, can maintain skin respiration and can be applied for a long time by a film made of polyurethane; manufactured by 3M Company), and then will be filled The syringe of Chinese medicine paste 2 (in the case of b-FGF administration, the injection needle) presses the membrane and penetrates it, which is called administering the traditional Chinese medicine ointment 2 at the wound site (when b-FGF is administered) , for b-FGF). 4. <Subject substance, etc.> 4. 1 Test substance, comparative control substance and medium ^ Ο-a) Test substance: The traditional Chinese medicine ointment (Chinese medicine ointment 2) obtained from "Production Example 2". (b) Comparative control substance: "Fiblast (registered trademark) Spray 25" (refractory dermatological therapeutic drug, scientific research pharmaceutical (stock) manufacturing; batch number: G71183). (1-c) Physiological saline solution of medium (batch number: K7E83; manufactured by Otsuka Pharmaceutical Factory Co., Ltd.). q 4. 2 reagent: 3-mercapto-1-butanol (batch number: WKG6715; Wako Pure Chemical Industries Co., Ltd.), 2, 2, 2-tribromoethanol (batch number: Df> H794Q; Wako Pure Chemical Industries (share)), water for injection (batch number: 7C75N; Otsuka Pharmaceutical Factory (share)). 5. <Administration of the sample> 5.1 Modulation method 5. 1.1 Comparison of the preparation solution for the control substance. Comparison of the control substance: Dissolve by adding the entire amount of the attached solution (2.5 mL/piece) to make the concentration become 〇· Olw/v/% as the preparation stock solution 5. 1.2 Test substance and comparative control substance 32〇866 34 200942270 Test substance. Directly use traditional Chinese medicine ointment 2 as the test substance. For comparison, a control substance was added: 5 times the physiological saline solution was added to the prepared stock solution to dilute the concentration to 0. 〇〇 2w/v/%. 5. 1. 3 Anesthesia (Avertin: Avertin) Add 2,2,2-tribromoethanol to 3-methyl-1-butanol 2, and maintain the temperature in a warm bath at 37 °C. Dissolve it in minutes. Completely dissolved

After Q, 0.5 ml of this solution was added to 4 mL of water for injection and mixed up and down. 6. <Experimental Department> 6. 1 Experimental animals and feeding conditions The animal species used in the general pharmacodynamic experiment were used in the experiment, and the system was well-established with male BKS. Cg_+Leprdb/+Leprdb/Jcl (SiyP, Japanese Celia (Clea_japan) (share) β 隹 取得 隹 隹 3 3 3 3 该 该 该 该 该 该 该 该 该 该 该 该 该 该 该 该 该 该 该 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 These animals are set up for a five-day quarantine period and an eight-day acclimation period. Three times of measurement in this period (electronic balance used: PG2002-s, PB3〇〇2; METTLER, 托#) (Mettier Toledo International Inc.) and 1曰1 Observed in the general state, no abnormalities were used in the experiment. The animals were maintained at the set temperature: 23. (: (measured value: 22. 9 $ 23.7., ^ meaning), set humidity 55% (measured value: 51.3 to 57. 5%), light and dark each +, gas exchange times: 12 times / hour (filtered The fresh air of the net is sterilized by the net, and the room is raised in the room. The plastic tray and the water bottle are replaced twice a week, and the feed box is replaced more than once a week. 320866 35 200942270 The solid feed (CRF-l; lot number: 071105, 〇8〇1{) 7 曰 东方 东方 东方 东方 东方 东方 东方 东方 东方 东方 东方 东方 东方 东方 东方 东方 东方 东方 东方 东方 东方 东方 东方 东方 东方 东方 东方 东方 东方 东方 东方 东方 东方 东方 东方 东方 东方 东方 东方 东方 东方 东方Ingestion. 6. 2 grouping method and individual identification method grouping is carried out on the day of drug administration; after dividing the body weight by computer, it can be arbitrarily divided into 3 groups on the day of administration by random sampling method, each group is only 1,, ❹ ❹ The average body weight and dispersion of the animals in the group were almost the same (in addition, the animals that were divided into two groups were lethal). 6. 3 The dosage of the injection needle = the use of the third group of Buddy to cast the prepared coffee, the ointment 2 of the I:?), and as the second group of the ointment 4 (after use) Lost two: = fruit two 216 injection needle of polypropylene women's system - and other injection needles: hoarding; Terumo (stock) manufacturing). After the needle (or left shot) is filled with each dose of the drug c specimen φ Ml into the covered wound site, the puncture injection

Made by the company), Μ Name: TegadH Pharmacy Qianbu iQML (Q.imL) Pharmacy. The number is guaranteed once a day for 21 consecutive days. The traces were carried out between 2 pm and the wounds were made 曰^ 6.4 group, _ 1 body (10) bundles were implemented immediately. The first electricity, the dose, and the use of the animal are only counted, and (there are 10 helmets in the second group (the Chinese (four) cloth (disposal).) The disposer has 10 ' and 10 (the Shi B'F disposer has 10): coated i〇〇#L. 320866 36 200942270 — 7. <Experimental method> '7 · 1 Skin wound preparation Three days before the resection, the hair of the back of the experimental animal was shaved with a whisker and the hair was removed with a hair removal cream. After grouping, under the anesthesia of "Avertin" [杈 and liquid, body weight (g) x 〇. 02+0· 〇 5mL; administration route: intra-abdominal], will be centered on the back midline The skin is removed by eye ophthalmology to remove the skin of I.—to make a skin wound (the first wound of the wound). ^ 然 然 然 然 然 然 然 然 然 然 然 然 然 然 然 然 然 然 然 然 然 然 然 然 然 然 然 然 然 然 然 然 然 然 然 然 然 然 然 然 然 然 然 然 然 然 然 然 然 然 然 然 然 然 然 然Tracing the contour of the wound site once a day on days 1, 3, 5, 7, 9, 11, 13, 15, 17, 19, and 21, and using the area as a product (Super PLANIX β ; TAMAYA Measurement system (unit)) measurement. Animals judged to have "healed" in the skin wound site are no longer traced, and Q is made to have the area of the wound site set to zero. The area on the first day (day) of the administration was set to 1%, and the area ratio of each administration 求出 was determined, and the area under the curve (AUC) of the wound site area versus elapsed time was obtained from the number of administration days according to the following formula. AUC=(a+k)+2(b+c+d+e+f+g+h+i+j) a: area ratio on the first day of administration, b: area ratio on the third day of administration, c: Area ratio on the 5th day of administration, d: Area ratio on the 7th day of administration, 320866 37 200942270 e · Area ratio on the 9th day of administration, • f: Area ratio on the 11th day of administration, g: Day 13 on administration Area ratio, h: area ratio on the 15th day of administration, i: area ratio on the 17th day of administration, j: area ratio on the 19th day of administration, k: area ratio on the 21st day of administration. 7. 3 General state D Contains the general state of death, observed 1 time before daily dosing. 7.4 Body weight determination Body weight is determined on days 1, 7, 14 and 21 of the wound production (measured prior to administration on the dosing date) (electronic balance used: PG2002-S; METTLER TOLEDO) Manufacturing). 7. 5Photographing p Take the photo of the whole case on the 1st, 7th, 14th and 21st day of the trauma production (take the shot before the administration). 8. Statistical Methods Body weight, area of the wound site from day 1 to day 21, and area of the wound site to the area under the curve of the elapsed time (AUC). Average of each group: h standard error. The determination of sexual differences between the untreated control group and each drug-administered group is considered to be less than 5%, and each is expressed as less than 5% (p<0.05) and less than 1% ( ρ&lt;0. 01). The verification method is based on the Bartlett test, 38 320866 200942270 &quot; etc., using the Dunnett test for dispersion, and the non-parametric test for non-parametric test. In the test, use SAS Pre-Clinical Packing Version 5. S (SAS Institute Japan). 9. Experimental results 9. 1 General status There is no abnormality in the general state of any group during the administration period. 9. 2 Weight The results are presented in Figure 1 and Table 2. ^ In the untreated group, the average body weight on the first day (the day) was 45.4 ± 〇. 5g, but gradually decreased during the administration period. 'On the 21st day of administration, it became 38.5 ± 1. 5g 〇 Manufactured In the administration group of the traditional Chinese medicine ointment obtained in Example 2, the average body weight on the first day (the day) was 45·4±0.4 g, but gradually decreased during the administration period, and became 35.1:1 on the 21st day of administration. : 0. 8g. Although the value was lower than that of the untreated group 'on the measurement day after the 14th day of administration, no significant difference was observed in the measurement day of any of 0 days. &quot; In the b-FGF treatment group, the average body weight on the first day of administration was 45. 3±0. 4g 'but gradually decreased after administration of the drug'. On the 21st day of administration, it became 38. 3 soil〇·9g . Almost the same body weight change was observed compared to the untreated group, and no significant difference was observed. 9. 3 The area of the wound site of the skin and the area under the curve of the time of the wound site (AUC) are shown in Figures 11, 12 and 3. In the untreated group, the average area of the first day of the wound production (the day of the wounding) was 320.563, 2009, and the average area was 255.3 ± 6. 7 mm 2 . The area was changed to a fixed value on the 15th day of the wound production, and the wound area was gradually reduced from the 15th day of the wound production, but the wound area ratio of the wound preparation was still 62. 4± 5.8%. Moreover, there is no sign of recovery in the full case. The average of this c is 1885. 1±44. lmm2.至1. lmm2。 The average area of the wound on the first day of the wound production was 258.0 ± 9. lmm2. The area ratio was on the 7th day of the wound production (from the first day to the 7th day), and the area of the wound was increased as compared with the production, and after the 14th day of the wound production, there was inflammation around the wound site. However, the wound area was reduced by the number of days, but the wound area ratio of the 21st day of wound production was 43.7 ± 5.5%. Further, in the treatment group of the ointment 2 of the present invention, the "skin wound has healed" is not seen in the whole example. The average of this is 1472. 9+55. 1mm2 ° 0 Compared with the untreated group, the area ratio of the drug ointment 2 of the present invention shows a significant high value on the third day of administration, and in the nth, &amp; 15, 17 days and 19th day showed a significant low value. And the service is low.至4. 4mra2。 The average area of the wound on the first day of the wound production (the day of the wound) was 244.7±6. 4mra2. The wound area became smaller as the number of days after the wound was made, and the wound area ratio on the 21st day of wound production was only 1. 2 ± 〇K. Also, 6 of the 1 cases have recovered. The average is 1135. 5±33. 3mm2. Compared with the untreated group, the area of the b_FGF treatment group, the area of 320866 40 200942270 - showed a significant low value on the 9th, 11th, 13th, 15th, 17th and 19th days of administration. And AUC also showed a significant low value. 10. &lt;Conclusion&gt; A wound portion was formed on the back of a 12-week-old mouse (db/db mouse) having hereditary diabetes, and the traditional Chinese medicine ointment (Chinese medicine ointment 2) obtained in Production Example 2 was subjected to one day. One coat was applied, and the area of the wound site was measured once every two days to investigate the effect of the Chinese herbal ointment 2 on promoting healing. From the results, it was found that the traditional Chinese medicine ointment (Chinese medicine 0 ointment 2) obtained in Production Example 2 exhibited a remarkable high value on the third day of administration, and was remarkable on the 11th, 13th, 15th, 17th, and 19th days. The low value of sex is thus determined to promote healing. Moreover, the area under the curve of the wound site (AUC) also showed a significant low value, which was judged to have a promoting healing effect. However, the traditional Chinese medicine ointment (Chinese medicine ointment 2) obtained in Production Example 2 used this time, after the 14th day of administration, has a lower body weight than the untreated group, and there is an indication of inflammation around the wound portion of the back skin. Therefore, after the 17th day of administration, the reduction in the area of the wound site was stagnant. Although the reason for this is not clear, the sample (agent) is an ointment, so in the closed-type administration method, it is not easily absorbed by the skin, and the sample remains in the polyurethane film "Tegaderm". situation. Therefore, judging the daily continuous administration of the drug will increase the burden on the animal and withstand the stress, which in turn will affect the weight loss and the reduction of the wound site area. However, in the rat skin cut test shown in Experimental Example 11, the "b-FGF" which is a commercially available acne therapeutic agent has a stronger effect of promoting healing, and shows that the present invention obtained by Production Example 2 is shown in 41 320866 200942270' The utility of traditional Chinese medicine ointment. • Moreover, even in the efficacy of skin wounds in mice with hereditary diabetes (db/db mice), it has been shown to promote healing. As described above, the traditional Chinese medicine ointment (Traditional Chinese Medicine Ointment 2) of the present invention obtained in Production Example 2 was administered by the daily sealing, and was not easily absorbed by the skin, but had an effect of promoting healing of the skin wound of db/db mice. 0 0 42 320866 200942270' [Table 2] &quot;--gg^^J^BSq^ ~ u } t_g14 aojm qp/qpplsvlM'BAlsI^^O ^ospwuoosTJl esaumuJeslai^tuwM. #礆wlfn^剌从φ[·ιί _刼&gt;(1 ,f'qp/qp)1七堞竣黎杯, ¥葙2 and #濂午) 头盔愈4.2崦00 s (»4 5 41 -Η -« -Η fn ^ ^ η

I s §§§§ 〇 〇 O 67 •M Province 41 « 3 ▼-['—

m βο ^ irv o o *-: J =τ 2ε =rm 屮-5

1N - L m

Alkali B Zhu Zhang ios^Q 趄 鞑碡 鞑碡 (dnoJ3 10.14-&gt;§3)璁馁*矣锑要:00艺W瞵+ι(ω)^Barren carbon¥砟baew ^paes J εα« ^ §5ΑΜ»« «οζ ri-w ^ ^ I gq g^qjws^p IP·808 43 320866 200942270' [Table 3] §Λ si ts f 3^$ s-«rl i 3 Ϊ9·ί 5 3 + 6 = 5 3 iF-o: sec ^ s ir? Λ- 5W i 5 ^ 2t sz-f 屮* SNt-ϊ Is S27 « 9 5 屮--t5? ο ο 蜣The Φ婶銮^f_f_^w2 ,【 , qp/qp)^七墚呦 invites more «-te'f-iiz such as 镰-fr-ws^4co^ zswitb^4 giau , l§

刍鲑3⁄4 ^ J ^Ms J s eoMS^O 8Έ^1 e^Je^a M^KSW

^oiQ -4 t fggs i S5 i g? o? ^f^vr^ri^oi^iri^etriwi ψ\

«3S =F1 ,£'5 •+lm -Hm «6Ί5 •Hti «m ^ β·ιβ •Mn2 ·«i *s2 Ξ] 4i -if -« *»«·« -H&gt;if ·«·♦ &lt; Ή -tf •n •Oa g ?|S|iSiiS3| ΛΦΙΓ· Xuan a frpi a frpil X*MI 1.11 3--3⁄43⁄4 3*pt &gt;vf»s.言1 (X)斋矣.il( w赛" 钽荦s*f««?-tt! S18-li^ee{ &B6 (s day s&gt;#«w趄费串gs ss ^so^. (3⁄43⁄4. 寒^墙碟翊(&amp ; 23^Sweep 1103)逋&:*Food Gallium:^ ΛΙ0·0Μ**)Μ·¥ 铤&quot; f ^δ§?1§ (赛vsi录电&gt;5?啻瓒璩*没有Grandfather umbrella fsMV隼W瞵'+lw%fel·嫦迤 tons d»0&amp; ^§8 *€8§ ^1V9S« .^5.£ 1 &s» lfw« §slx • ^us^s^ §s&lt; ΰ3^ _ yg^lrps gmfMoy gnpA qaig 44 320866 Ο Ο 200942270 [Industry use] - Generally, in the treatment of hemorrhoids, injury, if (four) carrion, _ remove the necrosis affecting the injury Group iron, called injury. Debridement (for the surgeon to use II to remove or use a specific secret (four) preparation to soften the necrotic tissue) 'When the wound necrotic tissue is cleaned, it is normal to grow new tissue. However, the patient For the injury π disposal The pain and the fineness (4) force, often read the sputum, sometimes in the d repulsion and the healing of the wound. The plaster of the present invention from the initial stage of application to the restoration, the antibiotics such as pathogenic bacteria and the like may cause side effects of the drug #j, However, only the plaster of the invention is applied (the gauze is replaced several times, the polyester is only ^^, and the pair is too double, which can effectively remove necrosis, weave, and promote the formation of new muscles. The ointment also has the function of inhibiting the exudate, keeping the wound in a wet and moist state to facilitate the recovery of the wound. Therefore, it does not bring pain and mental load to the patient's body, and avoids surgery and the like. Economic pressure, and can shorten the time of recovery. Therefore, for the patient itself and his family, the herbal ointment of the present invention is excellent in terms of restorativeness, mentality, physicality, economy, and time. Ten kinds of Chinese herbal medicines such as dried ginger, aconite (or medicinal aconite), cinnamon, medlar, Wusong, peony, magnolia, frankincense, myrrh, catechu, and the extract of mycoplasma mycelium are effective. Points, but the formula can be adjusted according to the actual symptoms. 320866 200942270 ' According to the inventor's theory of traditional Chinese medicine, the above ten kinds of Chinese herbal medicines are obtained. Among them, dried ginger, aconite (or artemisia) and cinnamon are indispensable components. The present invention has been accomplished by focusing on the results of repeated studies and achieving the therapeutic Chinese medicine composition for trauma, hemorrhoids, and the traditional Chinese medicine ointment for trauma and hemorrhoids. The combination of the preparation of the present invention includes the following: The preferred formula may be "dry ginger, aconite (or artemisia), cinnamon, and pepper combination", and "dry ginger, aconite (or artemisia), cinnamon, and pepper. , ^ Combination of Mycorrhizal Mycelium Extracts. A better formula can be a combination of "Ginger, Aconite (or Aconite), Cinnamon, Amaranth, and Evodia, as well as dried ginger, aconite (or aconite), cinnamon, pepper, Wujing 11, and Flammulina mycelium extract. Combination." A better formula can be "dry ginger, aconite (or artemisia), cinnamon, peony, sorghum, peony, and dried ginger, aconite (or artemisia), cinnamon, peony, peony, peony, Acerola A combination of mycelium extracts." Another better formula can be "dry ginger, aconite (or cannon), cinnamon, peony, sorghum, peony, magnolia combination, as well as dried ginger, aconite (or artemisia), cinnamon, peony, peony, peony, thick Combination of Park and Flammulina mycelium extracts. A better formula can be "Dried Ginger, Aconite (or Aconite), Cinnamon, Amaranth, Wushuang Shuang, Peony, Magnolia, Frankincense, Myrrh, and Dried Ginger, Aconite (or Aconite), Cinnamon, Pepper, Combination of Wusong, Peony, Magnolia, Frankincense, Myrrh, and Flammulina Mycelium Extract. 46 320866 200942270 - The best formula can be "dry #, aconite (or _ child), cinnamon, 蜀 * pepper, 茱萸 茱萸, peony, magnolia, frankincense, myrrh, catechu, and dried ginger, aconite (or gun aconite), cinnamon, pepper, Wusong, and medicine, Magnolia, frankincense, myrrh, catechu, Flammulina velutipes mycelium extract combination. [Simplified description of the drawings] Fig. 1(A) shows the first photograph of the process of the sore wound to the soreness of the recommended part of the experimental example. ^ 帛1 ® (8) is the first picture of the illusion (the second picture of the illusion is shown in the process of the acne wound to the sore after the reading of the experimental part). Figure 1 (C) shows the experimental example In the process of treating the wound to the acne, the continuation of the third picture (the third picture of the illusion. The first │ (D) shows the acne wound of the recommended part of the experimental 丨 continuation of the third Figure (4th photo of 〇. Fig. 2(A) shows the first picture of the acne wound of the recommended part of the experimental example 2 until the sore. 0 Fig. 2 (B) shows the experiment The second photo of Figure 1 (A) is continued during the healing of the wound in the recommended part of Example 2. Figure 2 (C) shows the acne wound to the sore shown in the experimental example 2 The third picture of Fig. 1(B) is continued during the sore process. Fig. 2(D) shows the acne wound of the recommended part of the experimental example 2 until the recovery (Fig. 1) The fourth photo. The m (A) shows the third photo of the process from the wound of the bee-like tissue inflammation to the healing of the left heel in Experimental Example 3. Figure 3 (B) Presenting the left heel of the experimental example 3, the bee writing group 320866 47 200942270 'The second photo of the 3rd figure (A) is continued during the process of healing the wound of the inflammatory inflammation. Fig. 4 shows the experimental example 4 shows the photo of the wound of the cellulitis of the right lower leg until it is cured. Fig. 5(A) shows the photograph of the hemorrhoid wound of the buttocks shown in the experimental example 5 in the state of healing. Fig. 5 (B) shows the experiment Photograph of the hemorrhoid wound on the back shown in Example 5 in the state of healing. ® Figure 6 (A) shows the first photograph of the back of the hemorrhoid wound as shown in Experimental Example 6 until the recovery. Figure 6 (B) The second photograph of Fig. 6 (A) is shown in the process of presenting the acne wound on the back of the experiment example 6 to the recovery. Fig. 6 (C) shows the acne wound of the back shown in the experimental example 6 until it is cured. In the process, the third photograph of Fig. 6(B) is continued. Fig. 6(D) shows the fourth step of Fig. 6(C) in the process of showing the hemorrhoid wound on the back of the experiment example 6 to the healing Q. Photograph. Fig. 6(E) shows the process of the hemorrhoid wound on the back shown in Experimental Example 6 until it is cured. The fifth photograph of Fig. 6(D) is continued. Fig. 7(A) shows the first photograph of the acne wound of the abdomen shown in Experimental Example 7 until it is cured. Fig. 7(B) shows The second photograph of Fig. 7(A) is continued during the process of the hemorrhoid wound of the abdomen as shown in the experimental example 7. Fig. 7(C) shows the process of the hemorrhoid wound of the abdomen shown in the experimental example 7 until healed. The third photo of Figure 7 (B) is continued. 48 320866 200942270 Figure 7 (D) shows the fourth part of Figure 7 (C) in the process of the hemorrhoid wound of the abdomen shown in Experimental Example 7 Fig. 7(E) shows the fifth photograph of Fig. 7(D) in the course of the hemorrhoid wound of the abdomen shown in Experimental Example 7 until healed. Fig. 7(F) is a sixth photograph showing the continuation of Fig. 7(E) in the course of the hemorrhoid wound of the abdomen shown in Experimental Example 7 until healed. Fig. 8 is a photograph showing the improvement of the wound at the second toe joint of the left thumb as shown in Experimental Example 8. Fig. 9 is a graph showing the tensile strength after wound healing in the treatment of a mouse skin cut model by the Chinese medicine ointment (Chinese medicine of bedsore-2) of the present invention obtained in Production Example 2, as shown in Experimental Example 11. Strength (gile strength (g)) ° In addition, in Figure 9, the unstressed group (control group; control group) showed the strength of the wound after healing, and the wound healing after treatment with "b-FGF" Tensile strength. The figure is a graph showing the relationship between days of administration and body weight (g) in db/db mice in Experimental Example 12. In Fig. 10, "〇 and solid line" indicate a control group, "• and dashed line" indicate the case where the Chinese medicine ointment 2 of the present invention is administered, and "△ and solid line" indicate the case of administration of "b-FGF". Figure 11 is a graph showing the relationship between days of administration and change of wound lesion area (%) in db/db mice in Experimental Example 12 of the present invention. 0 49 320866 200942270 ' In Fig. 11, the relationship between the number of days of administration of the untreated group (control group; control 'group) and the rate of change of wound area in the db/db mice, and the pair of drugs "b-FGF" administered to the group db/ The relationship between the number of days of administration of db mice and the rate of change of wound area. In Fig. 11, "〇 and solid lines" indicate a control group, "• and broken lines" indicate the case where the Chinese medicine ointment 2 of the present invention is administered, and "△ and solid lines" indicate the case where "b-FGF" is administered. Fig. 12 is a view showing the experimental example 12, the medicinal ointment of the present invention (Chinese medicine of bedsore-2) obtained in Production Example 2 was administered to db/db mice and expressed in AUC (mm2). Healing effect. The control group and the investment situation of "b-FGF" were also included. [Main component symbol description] None 50 320866

Claims (1)

200942270 ' VII. Patent application scope: .1· - A traditional Chinese medicine composition for treating trauma or acne, which is characterized by containing dry ginger ^ aconite (or artillery aconite) and cinnamon as an active ingredient. 2. The weight ratio of dried ginger, aconite (or medicinal aconite) to cinnamon, which is the active ingredient of the traditional Chinese medicine composition for treating trauma or acne according to item 1 of the patent application, is 4:2:1. 3.=:=^: = 2, _ or acne. Ο 4. A treatment for traumatic sputum is a powdery component. Patent application: Chinese medicine ointment, which is characterized by: a traditional Chinese medicine composition containing ❼ dried ginger and aconite, characterized by: containing #6 such as application ^), cinnamon and peony as the active ingredient of the fifth item of treatment for trauma or In the extravagant Chinese medicine group, the mixture ratio of cinnamon to chopped pepper is 4:1·· 1:1. 8. (4) The fifth or sixth item of the treatment of trauma or pneumococcal ammunition, the active ingredients are powdered. The traditional Chinese medicine ointment is characterized in that it comprises a Chinese medicine composition such as a quantity of oil = a mixture of 5 to 7 of the divine brothers, and a traditional Chinese medicine composition for the treatment of trauma or hemorrhoids, which is characterized in that it contains eight aconites (or cannons). Aconite), cinnamon, devout and sage are the active ingredients. 320866 51 9. 200942270 ' 10. For the treatment of trauma or acne with Chinese medicine composition according to item 9 of the patent application, among them, dried ginger, aconite (or artemisia), cinnamon, pepper and Wusong are used as active ingredients. The mixing weight ratio is 4 : 1 : 1 : 1 : 1. 11. The pharmaceutical composition for treating trauma or acne according to claim 9 or 10, wherein each active ingredient is in the form of a powder. 12. A medicinal ointment for treating trauma or acne, which comprises the composition of a medicinal composition according to any one of claims 9 to 3, and an appropriate amount of a fascia. 0 13. A traditional Chinese medicine composition for treating trauma or acne, which is characterized by containing dried ginger, aconite (or medicinal aconite), cinnamon, peony, peony and peony as active ingredients. 14. The pharmaceutical composition for treating trauma or acne according to claim 13 of the patent application, wherein the weight ratio of dried ginger, aconite (or medicinal aconite), cinnamon, peony, sage and peony as an active ingredient is 4: 1 ·· 1 : 1:1:1. Q 15. A pharmaceutical composition for treating trauma or acne according to claim 13 or 14, wherein each active ingredient is in the form of a powder. A medicinal ointment for treating trauma or acne, which comprises a medicinal composition according to any one of claims 13 to 15 and an appropriate amount of emollient. 17. A traditional Chinese medicine composition for treating trauma or acne, which comprises: dried ginger, aconite (or medicinal aconite), + cinnamon, peony pepper, peony root, peony and magnolia as active ingredients. 18. For the treatment of trauma or acne, the Chinese medicine group 52 320866 200942270 ', the active ingredient of dried ginger, aconite (or artemisia), cinnamon, peony, peony, peony and thick The weight ratio of Park's mixture is 4:1:1:1:1:1:1. 19. For the treatment of trauma or acne, according to Article 17 or Item 18 of the patent application, wherein the active ingredients are Powdery. 20. A medicinal ointment for treating trauma or acne, which comprises a medicinal composition according to any one of claims 17 to 19, and an appropriate amount of emollient. &amp; 21. A traditional Chinese medicine composition for treating trauma or acne, which comprises: dried ginger, aconite (or medicinal aconite), cinnamon, peony, sorghum, peony, magnolia, frankincense, and myrrh as an active ingredient. 22. The composition of a traditional Chinese medicine for treating trauma or acne according to the scope of claim 21, wherein, as an active ingredient, dried ginger, aconite (or aconite), cinnamon, peony, peony, peony, magnolia, frankincense and no The mixture weight ratio of the medicine is 4 : 1 : 1 : 1 : 1 : i: 1 : 1 : 1. Q 23. A pharmaceutical composition for treating trauma or acne according to claim 21 or 22, wherein each active ingredient is in the form of a powder. 24. A medicinal ointment for treating trauma or acne, which comprises a medicinal composition according to any one of claims 21 to 23 and an appropriate amount of emollient. 25. A traditional Chinese medicine composition for treating trauma or acne, which is characterized by containing dried ginger, aconite (or medicinal aconite), cinnamon, peony, peony, peony, magnolia, frankincense, myrrh and catechu as active ingredients. . 26. For the treatment of trauma or acne in the 25th paragraph of the patent application section 53 320866 200942270 The compound 'in which' as the active ingredient of dried ginger, aconite (or artemisia), cinnamon, peony, peony, peony, magnolia The mixture ratio of frankincense, myrrh and catechu is 4 : 1 : 1 : 1 : 1 : 1 : 1 : 1 : 1 : 1. 27. In the treatment of trauma or acne according to claim 25 or 26 of the patent application: Composition 'wherein, each active ingredient is in powder form. 28. A traditional Chinese medicine ointment for treating trauma or acne, characterized by: 申 Apply for the 27th Chinese medicine composition of the patent dry circumference and the appropriate amount of grease. 29. If the patent application scopes 1 to 3, 5 to 7, 9 to 11, 1 to 15, 17 to 19, 21 to 23, 25 to 27 / oral trauma Or a traditional Chinese medicine composition for treatment, in which an extract of yam-shrimp-filament extract is additionally contained as an active ingredient. 3〇. For example, the content of the traditional Chinese medicine composition for the treatment of traumatic diarrhea in the patent scope f29 is 'the content of the towel' Jinta® g filament extract, compared to other dried ginger and aconite U cannon as an active ingredient&gt; , _, _, = 茱m magnolia, (four), myrrh and total content of catechu] by weight, 〇.〇1 to 0.27 parts by weight. For example, the therapeutic composition of the external Chinese medicine is in the 29th or the third aspect of the patent application, wherein the filament is powdery. Bu wound or sore used 32.: A kind of traditional Chinese medicine ointment for treating trauma or hemorrhoids. Applying for a patent, the 29th item of the item - the towel of the item contains a proper amount of oil agent. Music, 'and products 320^55 54