CN105232650A - Unguent for treating scalds and preparation and application methods thereof - Google Patents
Unguent for treating scalds and preparation and application methods thereof Download PDFInfo
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Abstract
The invention relates to an unguent for treating scalds and preparation and application methods thereof. The unguent comprises the following raw materials in parts by weight: 32-48 parts of glutton fat, 32-48 parts of giant salamander meat, 12-18 parts of sesame oil, 1.6-2.4 parts of rhizoma polygoni cuspidati, 1.6-2.4 parts of radix scutellariae and 0.8-1.2 parts of borneol. The preparation method of the unguent for treating scalds comprises pre-treating raw materials, grinding, fermenting and stirring into a plaster. The application method comprises the step of directly applying the unguent at a scalded wound surface, or after applying the unguent to gauze or making the unguent into ointment gauze, applying to the scalded wound surface. The unguent for treating scalds and the preparation and application methods thereof has the beneficial effects that according to related theories of traditional Chinese medicine that lung governs skin and hair and gallbladder governs balance, the herbs are used together and reasonably compatible to achieve definite curative effects; when applied to a scald, the unguent can relieve pain and prevent infection, also inhibit the scald surface of a patient from necrocytosis and accelerate cell division, is high in efficiency and avoids scars after curing.
Description
Technical field
The invention belongs to a kind of pharmaceutical preparation for the treatment of scald, burn, electric injury and malicious abscess, be specifically related to a kind of ointment and preparation and application thereof for the treatment of scald.
Background technology
Burn and scald often occurs in daily life, to the patient be in a bad way, if treatment or malpractice not in time, is just easy to cause the infection of wound, suppurates, festers, leave permanent cicatrix, What is more entail dangers to life.At present in treatment burn and scald, the Chinese patent medicine ubiquity prescription applied clinically is complicated, and cost is high; In treatment burn and scald, there is common issue is weak curative effect, and the course for the treatment of is long, and anti-infection effect is poor, and Transdermal absorption is slow, easily cross infection occurs, severe one threat to life in therapeutic process, and the lighter makes skin graft or leaves over cicatrix, has increased the weight of economy and the mental burden of patient.
Summary of the invention
In order to solve the problems referred to above that prior art exists, the invention provides a kind of ointment and preparation and application thereof for the treatment of scald.
The technical solution adopted in the present invention is:
Treat an ointment for scald, comprise the raw material of following weight: glutton fat 32-48 weight portion, Andrias davidianus Blanchard 32-48 weight portion, Oleum sesami 12-18 weight portion, Rhizoma Polygoni Cuspidati 1.6-2.4 weight portion, Radix Scutellariae 1.6-2.4 weight portion, Borneolum Syntheticum 0.8-1.2 weight portion.
Further: a kind of ointment for the treatment of scald: the weight portion of the raw material comprised and each raw material is: the raw material comprising following weight: glutton fat 40 weight portion, Andrias davidianus Blanchard 40 weight portion, Oleum sesami 15 weight portion, Rhizoma Polygoni Cuspidati 2 weight portion, Radix Scutellariae 2 weight portion, Borneolum Syntheticum 1 weight portion.
A kind of preparation method for the treatment of ointment for scald: its preparation process is as follows:
1) take Borneolum Syntheticum, Andrias davidianus Blanchard, Rhizoma Polygoni Cuspidati, Radix Scutellariae respectively by above-mentioned weight ratio, pulverize as powder respectively, for subsequent use;
2) by step 1) in the Andrias davidianus Blanchard powder of gained and Oleum sesami mixed culture fermentation obtain fermented product, by the fermented product of gained and glutton fat and step 1) in the Giant Knotweed Rhizome of gained, Baical Skullcap Root, borneol powder carry out the pasty masses that stirs to obtain, a period of time is preserved in the sealing of gained pasty masses, the ointment of scalding must be treated.
Andrias davidianus Blanchard further: step 1) is adopted and obtains with the following method: dissect after being cleaned by freezing Andrias davidianus Blanchard, after the internal organs that pick a bone, natural air drying to moisture is that 7-8% is for subsequent use.
Rhizoma Polygoni Cuspidati further: step 1), Radix Scutellariae carry out following pretreatment, take described Rhizoma Polygoni Cuspidati, Radix Scutellariae respectively, and after cleaning, natural air drying to moisture is for subsequent use after 7-8%.
Glutton fat further: step 2) is adopted and is obtained with the following method: in the hibernation season of badger, slaughtered, get its fat composition and enter pot, add the water being equivalent to its fat composition quality 1/9-1/10, evaporate completely with the moisture of coddle to mixture, separate out fat, then gained fat filtered and obtains glutton fat, finally gained glutton fat being saved backup under the low temperature of 0 DEG C.
Slaughter in the hibernation season of badger, now the fat of badger is the thickest, easily obtains.Described slow fire slow fire is that firepower is little and slow, and temperature rises slowly, and water evaporates is slower.The clarification filtration of glutton fat is natural sedimentation one week, gets upper strata fat eliminating and filters impurity.
The preparation method of fermented product further: step 2) is: after Oleum sesami is clarified 60 days naturally, get upper strata edible vegetable oil, adds in described edible vegetable oil by described Andrias davidianus Blanchard powder, normal temperature fermentation 10 weeks, stirs once, to obtain final product every 48 hours.
Being fermented in Oleum sesami by Andrias davidianus Blanchard powder is dissolve each other to allow respective composition discharge completely, so that absorption of human body, the cell of damage is brought back to life, and accelerates the division of active somatic cell.
Adopt ball milling to carry out described pulverization process further: step 1), after pulverization process, the powder diameter of described Borneolum Syntheticum, Andrias davidianus Blanchard, Rhizoma Polygoni Cuspidati, Radix Scutellariae is more than 140 orders.
Ball milling is the percussion of abrasive body (as steel ball, cobblestone etc.) that utilizes and abrasive body and the abrasive action of ball milling inwall and being mixed by crushing material, can be used for dry grinding or wet grinding; Operating condition is good, pulverizes and carries out in airtight machine, does not have dirt ash to fly upward; Can intermittently operated, also can continued operation.
Further: step 2), the sealing holding time of gained pasty masses is 9-12 week.
Preferably: ointment for described ointment is applied directly to scald wound place, or is applied on gauze or spreads on scald wound place after making ointment gauze by the using method of above-mentioned ointment.
For the ease of understanding the present invention, below the raw material in the present invention and drug effect are further elaborated.
Glutton fat: by the fat extracted oils and fats of badger is that treatment is scalded, the active drug of burn.
Andrias davidianus Blanchard (Classification system: Andriasdavidianus), in Andrias davidianus Blanchard fat, unsaturated fatty acid (UFA) is up to 71.13%, wherein monounsaturated fatty acid (MUFA) is 42.18%, polyunsaturated fatty acid (PUFA) is 28.15%, ω-6 type PUFA with health role is 13.10%, ω-3 type PUFA is 15.15%, to bleach the factor (CHF) containing a large amount of active collagen (COLLAGEN) and epidermis activity in Andrias davidianus Blanchard skin, human body skin can be made to keep elasticity, lubrication is fine and smooth, healthy delicate, be called as the holy product of skin care whitening, there is extremely strong beauty functions, salamander corium farinosum can treat burn, scald, especially to the treatment preventing from scar of the burn and scald of face.
Rhizoma Polygoni Cuspidati: be dry rhizome and the root of polygonaceae plant Rhizoma Polygoni Cuspidati PolygonumcuspidatumSieb.etZucc., there is dampness removing jaundice eliminating, heat-clearing and toxic substances removing, eliminating stasis to stop pain, effect of relieving cough and resolving phlegm.For jaundice due to damp-heat, stranguria with turbid discharge, leukorrhagia, rheumatic arthralgia, carbuncle sore tumefacting virus, burn due to hot liquid or fire, amenorrhea, lump in the abdomen, instep plays damage, cough due to lung-heat.
Radix Scutellariae (Classification system: ScutellariabaicalensisGeorgi), another name Radix Scutellariae, tsuchikane tea root, the root of Radix Scutellariae is used as medicine, bitter in the mouth, cold in nature, has heat clearing and damp drying, eliminating fire and detoxication, hemostasis, the effect such as antiabortive.Cure mainly the diseases such as epidemic febrile disease, upper respiratory tract infection, cough due to lung-heat, damp and hot jaundice, pneumonia, dysentery, hemoptysis, conjunctival congestion, frequent fetal movement, hypertension, carbuncle furuncle, " medicinal herbs among the people of science " are recorded: washout wound, has antisepsis.
Oleum sesami: containing unsaturated fatty acid and the aminoacid of needed by human, occupy first of each vegetable oil.Also contain abundant vitamin and the trace element such as ferrum, zinc, copper of needed by human, its cholesterol level is well below Animal fat, containing vitamin E abundant especially with than more rich linoleic acid, linoleic acid has reduction blood fat, vessel softening, reduces blood pressure, promotes microcirculatory effect.
Borneolum Syntheticum: have another name called sheet brain, Fructus Citri tangerinae sheet, Blumeae preparatum Tabellae, Borneolum Syntheticum, MEIHUA BINGPIAN, Dipterocarpus pilosus, Flos Mume brain, Borneolum Syntheticum brain, Mei Bing etc., that also useful Oleum Terebinthinae obtains through a series of chemical method technique by Compositae Herba Blumeae Balsamiferae stem and leaf or canella Borneolum Syntheticum Camphor tree branch and leaf through steam distillation and recrystallization and obtaining.It can be used for excess syndrome of stroke coma, for conjunctival congestion and swelling pain, sore throat aphtha, to swell and ache for skin infection, does not hold back after bursting.
Using method of the present invention: be directly coated on injury after cleaning, or ointment is applied to (or making ointment gauze) on gauze and spreads on wound surface.To change dressings every day depending on wound surface situation or the next day change dressings 1 time.Can add medicine to after general sterilization to FFI wound surface, just can add medicine to after having the wound surface of infection need remove secretions.To the average curative day 2-3 days of Superficial bums, the average curative day of deepⅱdegreeburn is about 7-10 days, and after curing, skin smooth as before, and pore demutation, preventing from scar, has significant curative effect.
Beneficial effect of the present invention is: relevant theoretical according to the traditional Chinese medical science, lung governing skin and hair, gallbladder sovereignty weighing apparatus, and said medicine share, compatibility is reasonable, determined curative effect, for scalding place, the anti-infection of pain relieving, and patient can be suppressed to burn face necrocytosis, accelerate the division of cell, instant effect, without cicatrix after curing.
Detailed description of the invention
Below in conjunction with specific embodiment the present invention made and further explain explanation; it is to be noted: the present invention is not limited to following preferred forms; anyone can draw other various forms of products under enlightenment of the present invention; no matter but any change is done in its shape or structure; every have identical with the application or akin technical scheme, all drops within protection scope of the present invention.
Embodiment one:
A kind of ointment for the treatment of scald: the weight portion of the raw material comprised and each raw material is glutton fat: 32 weight portions, Andrias davidianus Blanchard 32 weight portion, Oleum sesami 12 weight portion, Rhizoma Polygoni Cuspidati 1.6 weight portion, Radix Scutellariae 1.6 weight portion, Borneolum Syntheticum 0.8 weight portion.
Its making step is: 1) in the hibernation season of badger, slaughtered, get its fat composition and enter pot, add the water being equivalent to its quality 1/9, evaporate completely with the moisture of coddle to mixture, separate out fat, then namely gained fat clarification filtration is obtained glutton fat, gained glutton fat is saved backup under the low temperature of 0 DEG C.
Semen Sesami Nigrum is squeezed into oil latter 60 days of maturation is intrinsic pressure, and then natural sedimentation 55 days, gets its upper strata edible vegetable oil, saves backup under the low temperature of-4 DEG C.
Dissect after being cleaned by freezing Andrias davidianus Blanchard, after the internal organs that pick a bone, natural air drying to moisture is 10%;
After Rhizoma Polygoni Cuspidati, Radix Scutellariae being cleaned, natural air drying to moisture is for subsequent use after 10%;
2) by the Andrias davidianus Blanchard after Borneolum Syntheticum and process, Rhizoma Polygoni Cuspidati, Radix Scutellariae by weight ratio take, and ball milling is that 140 order powder are for subsequent use;
3) by step 2) in the Andrias davidianus Blanchard powder of gained add in proportion in Oleum sesami, natural fermentation 10 weeks, stirred every 42 hours and once obtain fermented product, by the fermented product of gained and glutton fat and step 2) in the Giant Knotweed Rhizome of gained, Baical Skullcap Root, borneol powder to stir in proportion to obtain pasty masses, namely gained pasty masses sealing preservation is obtained the ointment that treatment is scalded for 10 weeks.
Embodiment two:
A kind of ointment for the treatment of scald: the weight portion of the raw material comprised and each raw material is: glutton fat 40 weight portion, Andrias davidianus Blanchard 40 weight portion, Oleum sesami 15 weight portion, Rhizoma Polygoni Cuspidati 2 weight portion, Radix Scutellariae 2 weight portion, Borneolum Syntheticum 1 weight portion.
Its making step is: 1) in the hibernation season of badger, slaughtered, get its fat composition and enter pot, add the water being equivalent to its quality 1/10, evaporate completely with the moisture of coddle to mixture, separate out fat, then namely gained fat clarification filtration is obtained glutton fat, gained glutton fat is saved backup under the low temperature of 0 DEG C.
Semen Sesami Nigrum is squeezed into oil latter 60 days of maturation is intrinsic pressure, and then natural sedimentation 60 days, gets its upper strata edible vegetable oil, saves backup under the low temperature of 0 DEG C.
Dissect after being cleaned by freezing Andrias davidianus Blanchard, after the internal organs that pick a bone, natural air drying to moisture is 8%;
After Rhizoma Polygoni Cuspidati, Radix Scutellariae being cleaned, natural air drying to moisture is for subsequent use after 8%;
2) by the Andrias davidianus Blanchard after Borneolum Syntheticum and process, Rhizoma Polygoni Cuspidati, Radix Scutellariae by weight ratio take, and ball milling is that 200 order powder are for subsequent use;
3) by step 2) in the Andrias davidianus Blanchard powder of gained add in proportion in Oleum sesami, natural fermentation 10 weeks, stirred every 48 hours and once obtain fermented product, by the fermented product of gained and glutton fat and step 2) in the Giant Knotweed Rhizome of gained, Baical Skullcap Root, borneol powder to stir in proportion to obtain pasty masses, namely gained pasty masses sealing preservation is obtained the ointment that treatment is scalded for 10 weeks.
Embodiment three:
A kind of ointment for the treatment of scald: the weight portion of the raw material comprised and each raw material is: glutton fat 48 weight portion, Andrias davidianus Blanchard 48 weight portion, Oleum sesami 18 weight portion, Rhizoma Polygoni Cuspidati 2.4 weight portion, Radix Scutellariae 2.4 weight portion, Borneolum Syntheticum 1.2 weight portion.
Its making step is: 1) in the hibernation season of badger, slaughtered, get its fat composition and enter pot, add the water being equivalent to its quality 1/8, evaporate completely with the moisture of coddle to mixture, separate out fat, then namely gained fat clarification filtration is obtained glutton fat, gained glutton fat is saved backup under the low temperature of 2 DEG C.
Semen Sesami Nigrum is squeezed into oil latter 60 days of maturation is intrinsic pressure, and then natural sedimentation 65 days, gets its upper strata edible vegetable oil, saves backup under the low temperature of-4 DEG C.
Dissect after being cleaned by freezing Andrias davidianus Blanchard, after the internal organs that pick a bone, natural air drying to moisture is 6%;
After Rhizoma Polygoni Cuspidati, Radix Scutellariae being cleaned, natural air drying to moisture is for subsequent use after 6%;
2) by the Andrias davidianus Blanchard after Borneolum Syntheticum and process, Rhizoma Polygoni Cuspidati, Radix Scutellariae by weight ratio take, and ball milling is that 250 order powder are for subsequent use;
3) by step 2) in the Andrias davidianus Blanchard powder of gained add in proportion in Oleum sesami, natural fermentation 10 weeks, stirred every 48 hours and once obtain fermented product, by the fermented product of gained and glutton fat and step 2) in the Giant Knotweed Rhizome of gained, Baical Skullcap Root, borneol powder to stir in proportion to obtain pasty masses, namely gained pasty masses sealing preservation is obtained the ointment that treatment is scalded for 10 weeks.
Use the method for medicine for external use of the present invention: burn and scald is not got blister, and directly ointment is applied to affected part.If get blister, can medicine be coated in around blister, not puncture blister, blister applies on a small quantity.The heavier exfoliation of the condition of the injury, dip in drug application in hindering face with sterile tissue gauze, face to be hindered drying changes direct coating into.Scald for I degree, medication 1 to 2 time every day, can fully recover for about 3 days, II degree is scalded, and medication 3 to 4 times every day, can fully recover for 3-5 days, III degree is scalded, from scald in 3 days, medication 3 to 4 times every day, in 3-7 days, every day medicine 2 to 3 times, after 7 days, every day, medicine 1 to 2 time, can fully recover for usual 7-10 days.Occur after coating that use is avoided in the anaphylaxis such as pruritus, erythra.The present invention both can cure burn and scald, also all can cure knife injury, gunshot wound, electric injury and malicious abscess etc.
Clinical efficacy example:
Mr. Jiao, the safe and comfortable people in Shaanxi Province, caught fire on November 15th, 2010 burn at home accidentally, and burn surface area reaches 65%, has no improvement in Xi'an hospitalize a couple of days, use the present invention treats, only be clearly better by 3 days burn site, be used in conjunction this medicine and be almost recovered for 9 days, pore demutation, without cicatrix, curative effect is remarkable.
Mrs Liang, goes out to get into an accident, and glass disintegrating slag large area scratches skin, and after hemostasis cleaning wound, treat recovery from illness in 5 days with this medicine, skin recovers as before.
Mr. Wang, company of Shaanxi Province electrician, arm is accidentally by electric injury at work, voluntarily after cleaning wrapping, gets blister, the long 12cm of wound, wide 4cm, use Scald Ointment to stick, worsen two days later, and red and swollen stream is dense, a burst of twinge, treats with this medicine, takes a turn for the better after 2 days on the 3rd day, decrustation recovery from illness after 6 days.
Clinical practice is added up:
Scald can be divided into I degree to scald (erythematous, erythrosis), II degree scald (vesiculovirus, affected part produces blister), III degree scald (gangrenosum acne, skin is cut).For proving drug effect, inventor selects 60 routine case observations selectively, number 45 example is scalded below II degree, III degree scalds number 15 example, and the burned patient 60 selecting medical history, the state of an illness, age, sex and former Therapeutic Method suitable example is for matched group, these patients from in-patient department and special outpatient clinic as selection case subjects, be the object of observation with the burned patient made a definite diagnosis, wherein man, each 30 examples of women, the age is less than 70 years old, and the course of disease is not limit.Test group: using or commonly using without the initial stage on the basis of method process, discontinue medication, use medicine for external use of the present invention.Matched group: Therapeutic Method process routinely, medication.Medication two group usage, consumption match, no more than three months of observation period.
Observed result is as follows:
After using this medicine to treat, scald healing number 45 people, cure rate 100%, effective percentage 100% below II degree, all without cicatrix, III degree scalds healing number 15 people, and cure rate 100%, effective percentage 100%, all without cicatrix.
| Group | Case load | Treatment of scald effect below II degree | III degree treatment of scald effect |
| Experimental group | 60 people | Symptom is eliminated, wound healing | Pain disappears, and epidermis heals |
| Matched group | 60 people | Symptomatolytic 3/5 | Symptomatolytic 1/3 |
Claims (10)
1. treat the ointment of scald for one kind, it is characterized in that, comprise the raw material of following weight: glutton fat 32-48 weight portion, Andrias davidianus Blanchard 32-48 weight portion, Oleum sesami 12-18 weight portion, Rhizoma Polygoni Cuspidati 1.6-2.4 weight portion, Radix Scutellariae 1.6-2.4 weight portion, Borneolum Syntheticum 0.8-1.2 weight portion.
2. ointment according to claim 1, is characterized in that, comprises the raw material of following weight: glutton fat 40 weight portion, Andrias davidianus Blanchard 40 weight portion, Oleum sesami 15 weight portion, Rhizoma Polygoni Cuspidati 2 weight portion, Radix Scutellariae 2 weight portion, Borneolum Syntheticum 1 weight portion.
3. a preparation method for ointment as claimed in claim 1 or 2, is characterized in that, comprise the following steps:
1) take Borneolum Syntheticum, Andrias davidianus Blanchard, Rhizoma Polygoni Cuspidati, Radix Scutellariae respectively by above-mentioned weight ratio, pulverize as powder respectively, for subsequent use;
2) by step 1) in the Andrias davidianus Blanchard powder of gained and Oleum sesami mixed culture fermentation obtain fermented product, by the fermented product of gained and glutton fat and step 1) in the Giant Knotweed Rhizome of gained, Baical Skullcap Root, borneol powder carry out the pasty masses that stirs to obtain, a period of time is preserved in the sealing of gained pasty masses, the ointment of scalding must be treated.
4. preparation method according to claim 3, is characterized in that, step 1) described in Andrias davidianus Blanchard adopt and obtain with the following method: dissect after being cleaned by freezing Andrias davidianus Blanchard, after the internal organs that pick a bone, natural air drying to moisture is that 7-8% is for subsequent use.
5. preparation method according to claim 3, is characterized in that, step 1) described in Rhizoma Polygoni Cuspidati, Radix Scutellariae carry out following pretreatment, take described Rhizoma Polygoni Cuspidati, Radix Scutellariae respectively, after cleaning, natural air drying to moisture is for subsequent use after 7-8%.
6. preparation method according to claim 3, it is characterized in that, step 2) described in glutton fat adopt and obtain with the following method: in the hibernation season of badger, slaughtered, get its fat composition and enter pot, add the water being equivalent to its fat composition quality 1/9-1/10, evaporate completely with the moisture of coddle to mixture, separate out fat, then gained fat filtered and obtains glutton fat, finally gained glutton fat being saved backup under the low temperature of 0 DEG C.
7. preparation method according to claim 3, is characterized in that, step 2) described in the preparation method of fermented product be: after Oleum sesami is clarified 60 days naturally, get upper strata edible vegetable oil, described Andrias davidianus Blanchard powder is added in described edible vegetable oil, normal temperature fermentation 10 weeks, stirred once every 48 hours, to obtain final product.
8. preparation method according to claim 3, is characterized in that, step 1) in adopt ball milling carry out described pulverization process, after pulverization process, the powder diameter of described Borneolum Syntheticum, Andrias davidianus Blanchard, Rhizoma Polygoni Cuspidati, Radix Scutellariae is more than 140 orders.
9. preparation method according to claim 3, is characterized in that, step 2) in sealing holding time of gained pasty masses be 9-12 week.
10. a using method for ointment described in claim 1 or 2, is characterized in that, described ointment is applied directly to scald wound place, or is applied on gauze by ointment or spreads on scald wound place after making ointment gauze.
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| CN110680878A (en) * | 2018-07-13 | 2020-01-14 | 莆田市肤宝生物科技有限公司 | Preparation method of ointment for treating burns and scalds |
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| CN101002834A (en) * | 2006-01-19 | 2007-07-25 | 上海玉森新药开发有限公司 | Traditional Chinese medicine composition for treating burns and scald |
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| CN101002834A (en) * | 2006-01-19 | 2007-07-25 | 上海玉森新药开发有限公司 | Traditional Chinese medicine composition for treating burns and scald |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN110680878A (en) * | 2018-07-13 | 2020-01-14 | 莆田市肤宝生物科技有限公司 | Preparation method of ointment for treating burns and scalds |
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