CN103181969B - A kind of Chinese medicine composition promoting wound healing - Google Patents
A kind of Chinese medicine composition promoting wound healing Download PDFInfo
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- CN103181969B CN103181969B CN201210538504.XA CN201210538504A CN103181969B CN 103181969 B CN103181969 B CN 103181969B CN 201210538504 A CN201210538504 A CN 201210538504A CN 103181969 B CN103181969 B CN 103181969B
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Abstract
The invention belongs to pharmaceutical technology field, specifically disclose a kind of Chinese medicine composition promoting wound healing and preparation method thereof. The Chinese medicine composition of the present invention is prepared from according to certain ratio by Radix Et Rhizoma Rhei, Cortex Phellodendri, Olibanum, Myrrha, Radix Notoginseng, catechu, Cortex Moutan, Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani), Radix Achyranthis Bidentatae and Semen Sesami wet goods. The present invention has the effect of cooling blood for hemostasis, reducing swelling and alleviating pain, bacteriostasis antibiosis, removing the necrotic tissue and promoting granulation, can accelerating wound healing.
Description
Technical field
The invention belongs to technical field of Chinese medicines, be specifically related to a kind of Chinese medicine composition promoting wound healing and preparation method thereof.
Background technology
Traumatic wound is hospital's urgency, the modal traumatic disease of outpatient service, is also the common disease in life. Traumatic wound belongs to contaminative wound more, and after wound within 6h-8h, antibacterial exists only in wound surface, still remains static, and whether appropriate treatment of wounds is timely, directly influences wound healing. How to treat and just can palliate the agonizing sufferings, avoid wound infection, promote wound healing, frequently with wound debridement and suturing in practice, apply alcohol gauze, every day or the method changed dressings every other day.
The ancient prescription of traditional treatment surgical wound has Shengji Yuhong Gao, incised wound SHENGJISAN, rotten SHENGJISAN, putrefaction-removing granulation-promoting paste etc. to the greatest extent.
Tian Chunling is in " clinical observation of cataplasm of tcm treatment facial area wound " (" Henan College Of Traditional Chinese Medicine journal " the 20th volume total 120th phase, 69th page) a kind of cataplasm of tcm disclosed in a literary composition, prescription is Cacumen Platycladi 60g, Radix Et Rhizoma Rhei 60g, Cortex Phellodendri 30g, Pollen Typhae 30g, Rhizoma Corydalis 25g, Sanguis Draxonis 10g, Radix Sophorae Flavescentis 20g etc.; All medicated powder is broken into fine powder, mixing of sieving, make powder standby. Heat, furnishing thickness pasty state mass, external application affected part is boiled with water, Mel in 4:1 ratio during use. The side of changing achieves good therapeutic effect. In clinic, the thickness of covering of this mass is with 0.6cm-1.2cm, if mass is too thin, moisture easily runs off and affects the persistency of drug effect; Mass is too thick, causes drug waste, and profile is unsightly, to causing patient activity's inconvenience.
The present inventor provides a kind of brand-new Chinese medicine composition promoting wound healing through long-term experimentation.
Summary of the invention:
It is an object of the invention to provide a kind of cooling blood for hemostasis, reducing swelling and alleviating pain, removing the necrotic tissue and promoting granulation, bacteriostasis antibiosis, promote the Chinese medicine composition of wound healing.
The present invention is achieved through the following technical solutions:
A kind of Chinese medicine composition promoting wound healing provided by the invention, it is characterised in that be made up of Radix Et Rhizoma Rhei, Cortex Phellodendri, Olibanum, Myrrha, Radix Notoginseng, catechu, Cortex Moutan, Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani), Radix Achyranthis Bidentatae, Semen Sesami wet goods raw material.
Preferably, a kind of Chinese medicine composition promoting wound healing provided by the invention, it is characterised in that be made up of the raw material of following weight portion:
Radix Et Rhizoma Rhei 40-120 weight portion Cortex Phellodendri 20-60 weight portion Olibanum 60-100 weight portion
Myrrha 30-60 weight portion Radix Notoginseng 30-60 weight portion catechu 60-100 weight portion
Cortex Moutan 40-80 weight portion Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) 20-50 weight portion Radix Achyranthis Bidentatae 30-80 weight portion
Oleum sesami 700-1200 weight portion
Most preferably, the Chinese medicine composition of the present invention is made up of the raw material of following weight portion:
Radix Et Rhizoma Rhei 100 weight portion Cortex Phellodendri 30 weight portion Olibanum 80 weight portion
Myrrha 40 weight portion Radix Notoginseng 60 weight portion catechu 80 weight portion
Cortex Moutan 70 weight portion Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) 40 weight portion Radix Achyranthis Bidentatae 40 weight portion
Oleum sesami 800 weight portion
Side of the present invention solves:
Radix Et Rhizoma Rhei: another name, general, Huang Liang, Radix Et Rhizoma Rhei etc., nature and flavor: bitter, cold.Gui Jing: stomach warp; Large intestine channel; Liver Channel; Spleen channel. Effect: attack stagnant; Clearing away damp-heat; Pathogenic fire purging; Removing heat from blood; Blood stasis dispelling; Removing toxic substances. It is mainly used as blood-cooling hemostatic in the present invention.
Cortex Phellodendri: another name, Cortex Phellodendri, Cortex Phellodendri, bark of a cork tree wood, bark of a cork tree skin. Meridian distribution of property and flavor: bitter, cold. Return kidney, bladder, large intestine channel. Function with cure mainly: heat clearing and damp drying, eliminating fire and detoxication, except hectic fever due to YIN-deficiency clearind deficient heat. It is used as clearing away heat to alleviate pain medicine in the present invention.
Olibanum: another name, smoked Lu Xiang, horse hair is fragrant, nipple is fragrant. Nature and flavor: arduous, temperature. Gui Jing: enter the heart, liver, spleen channel. Cure mainly: regulating qi and activating blood, analgesic therapy, chase after poison. Control coagulation of QI-blood, trusted subordinate's pain, ulcerative carbuncle toxic swelling, traumatic injury, dysmenorrhea, postnatal blood stasis twinge. Play the effect of activating blood circulation to dissipate blood stasis pain relieving in the present invention.
Myrrha: another name, myrrh, bright Myrrha etc. Nature and flavor: bitter, pungent, flat. Gui Jing: enter liver, spleen, the heart, kidney channel. Control traumatic injury, incised wound, muscles and bones, all pains of trusted subordinate, lump in the abdomen, amenorrhea, ulcer sore pain, anal fistula, diseases of the eye.
Radix Notoginseng: another name, Radix Stephaniae Sinicae (Radix Stephaniae Dielsianae), Herba Wedeliae Wallichii, mountain paint, Radix Notoginseng, Radix Notoginseng, Yunnan Radix Notoginseng, Rhizoma Bergeniae scopulosae etc. Nature and flavor: sweet in the mouth; Micro-hardship; Warm in nature. Gui Jing: return Liver Channel; Stomach warp; Heart channel; Lung meridian; Large intestine channel. Function: hemostasis; Dissipate blood; Analgesic therapy. Cure mainly: fall and flutter congestive edema, thoracic obstruction angor, lump in the abdomen; Blood stasis amenorrhea; Dysmenorrhea. The effect of activating blood circulation to dissipate blood stasis pain relieving is played in the present invention together altogether with Olibanum.
Catechu, calls CATECHU, Catechu, gambier. Meridian distribution of property and flavor: bitter, puckery, is slightly cold. Return lung meridian. Function cures mainly: removing dampness promoting tissue regeneration and ulcer healing. For ulcer being unable to heal, eczema, aphtha, fall and flutter the pain of injury, traumatic hemorrhage. Play anastaltic effect in the present invention.
Cortex Moutan: another name, moutan root bark, Cortex Moutan, DANGEN etc. Meridian distribution of property and flavor is cold in nature, bitter in the mouth; Cool; It is slightly cold. GUIXIN; Liver; Kidney; Lung meridian. Effect: clearing away heat and cooling blood; Promoting blood circulation to remove blood stasis. The epidemic febrile disease pathogenic heat attacking blood system in febrile diseases; Send out speckle; Tell nosebleed; Calentura later stage hot Fu Yin distribution heat; Deficiency of YIN osteopyrexia and fever; Amenorrhea due to stagnation of blood; Dysmenorrhea; Carbuncle sore tumefacting virus; Fall and flutter the pain of injury; Beriberoid pyretic arthralgia. Play clearing away heat and cooling blood in the present invention; The effect of promoting blood circulation to remove blood stasis.
Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani): another name, iron staff mallet, three and half. Meridian distribution of property and flavor: bitter, pungent, temperature. Very toxic. Function cures mainly: anti-inflammatory analgetic, expelling wind and removing dampness. It is used as narcotic analgesic medicine in the present invention.
Radix Achyranthis Bidentatae: another name, Radix Achyranthis Bidentatae, cattle stem, foot this pedal, car pusher knee joint, Du Radix Achyranthis Bidentatae, Radix Achyranthis Bidentatae etc. Gui Jing: liver; Kidney channel. Effect: invigorating the liver and kidney; Bone and muscle strengthening; Promoting blood circulation to restore menstrual flow; Ignite descending; Inducing diuresis for treating stranguria syndrome.
Oleum sesami: nature and flavor are sweet, cool, has effect of loosening bowel to relieve constipation, removing toxic substances and promoting granulation. Oleum sesami also serves as coordinating the actions of various ingredients in a prescription in the present invention.
In Chinese medicine composition of the present invention, Radix Et Rhizoma Rhei, Cortex Phellodendri, Olibanum, Myrrha, Radix Notoginseng, catechu, Cortex Moutan, Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani), Radix Achyranthis Bidentatae, all medicines of Semen Sesami wet goods can cooperate, mutually collaborative, both can cooling blood for hemostasis, reducing swelling and alleviating pain, again can bacteriostasis antibiosis, removing the necrotic tissue and promoting granulation, be finally reached the effect of accelerating wound healing.
Chinese medicine composition of the present invention can adopt the conventional method of pharmaceutical preparation to prepare into the multiple dosage forms such as oil preparation, paste, unguentum.
It is preferably oil preparation.
The preparation method that another object of the present invention is to provide a kind of Chinese medicine composition promoting wound healing, concrete technical scheme is as follows:
(1) weighing Radix Et Rhizoma Rhei, Cortex Phellodendri, Olibanum, Myrrha, Radix Notoginseng, catechu, Cortex Moutan, Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani), Radix Achyranthis Bidentatae in proportion, drying and crushing crosses 200 mesh sieves.
(2) Radix Et Rhizoma Rhei, Cortex Phellodendri, Cortex Moutan, Radix Achyranthis Bidentatae and Oleum sesami being soaked 12-24 hour with putting stirring in pot, slow fire heats to 80 DEG C-110 DEG C, is incubated 30-60 minute, is naturally cooling to room temperature.
(3) in step 2) in add the medicated powder such as Olibanum, Myrrha, Radix Notoginseng, Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani), slow fire heats to 30 DEG C-60 DEG C, is incubated 30-60 minute, and natural cooling obtains Chinese medicine composition oil preparation of the present invention.
Oil preparation of the present invention is easy to use, and for external used medicine, routinely to, after traumatic wound debridement and suturing, according to wound size clip oilpaper, being layered on equably above by oil preparation of the present invention, thickness is advisable with 0.2cm-0.4cm. Change dressings every day 1 time, until wound healing is taken out stitches.
The present invention is evident in efficacy, has cured patient more than 600 example, effective percentage 100%. Without valuable product in the present invention, Chinese medicine used source abundance, without in great shortage, the simple application easy to spread of its preparation technology, there is obvious economic and social benefit.
Detailed description of the invention
Hereinafter will further illustrate the present invention by specific embodiment, but and not limit the present invention in any way.
1. example of formulations:
Embodiment 1:
Weigh Radix Et Rhizoma Rhei 100g, Cortex Phellodendri 30g, Olibanum 80g, Myrrha 40g, Radix Notoginseng 60g, catechu 80g, Cortex Moutan 70g, Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) 40g, Radix Achyranthis Bidentatae 40g in proportion, be separately dried and pulverized 200 mesh sieves. The medicated powder such as Radix Et Rhizoma Rhei, Cortex Phellodendri, Cortex Moutan, Radix Achyranthis Bidentatae and Oleum sesami are soaked 24 hours with putting stirring in pot, slow fire heats to 105 DEG C, it is incubated 60 minutes, it is naturally cooling to room temperature, add the medicated powder such as Olibanum, Myrrha, Radix Notoginseng, Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani), slow fire heats to 55 DEG C, is incubated 60 minutes, and natural cooling obtains Chinese medicine composition oil preparation of the present invention.
Embodiment 2:
Weigh Radix Et Rhizoma Rhei 40g, Cortex Phellodendri 30g, Olibanum 60g, Myrrha 30g, Radix Notoginseng 30g, catechu 60g, Cortex Moutan 40g, Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) 20g, Radix Achyranthis Bidentatae 30g in proportion, be separately dried and pulverized 200 mesh sieves. The medicated powder such as Radix Et Rhizoma Rhei, Cortex Phellodendri, Cortex Moutan, Radix Achyranthis Bidentatae and Oleum sesami are soaked 18 hours with putting stirring in pot, slow fire heats to 100 DEG C, it is incubated 60 minutes, it is naturally cooling to room temperature, add the medicated powder such as Olibanum, Myrrha, Radix Notoginseng, Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani), slow fire heats to 55 DEG C, is incubated 60 minutes, and natural cooling obtains Chinese medicine composition oil preparation of the present invention.
Embodiment 3:
Weigh Radix Et Rhizoma Rhei 120g, Cortex Phellodendri 60g, Olibanum 80g, Myrrha 40g, Radix Notoginseng 60g, catechu 60g, Cortex Moutan 70g, Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) 50g, Radix Achyranthis Bidentatae 80g in proportion, be separately dried and pulverized 200 mesh sieves. The medicated powder such as Radix Et Rhizoma Rhei, Cortex Phellodendri, Cortex Moutan, Radix Achyranthis Bidentatae and Oleum sesami are soaked 18 hours with putting stirring in pot, slow fire heats to 90 DEG C, it is incubated 60 minutes, it is naturally cooling to room temperature, add the medicated powder such as Olibanum, Myrrha, Radix Notoginseng, Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani), slow fire heats to 60 DEG C, is incubated 30 minutes, and natural cooling obtains Chinese medicine composition oil preparation of the present invention.
Embodiment 4:
Weigh Radix Et Rhizoma Rhei 120g, Cortex Phellodendri 60g, Olibanum 100g, Myrrha 60g, Radix Notoginseng 60g, catechu 100g, Cortex Moutan 80g, Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) 50g, Radix Achyranthis Bidentatae 80g in proportion, be separately dried and pulverized 200 mesh sieves. The medicated powder such as Radix Et Rhizoma Rhei, Cortex Phellodendri, Cortex Moutan, Radix Achyranthis Bidentatae and Oleum sesami are soaked 24 hours with putting stirring in pot, slow fire heats to 110 DEG C, it is incubated 60 minutes, it is naturally cooling to room temperature, add the medicated powder such as Olibanum, Myrrha, Radix Notoginseng, Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani), slow fire heats to 60 DEG C, is incubated 60 minutes, and natural cooling obtains Chinese medicine composition oil preparation of the present invention.
Embodiment 5:
Weigh Radix Et Rhizoma Rhei 70g, Cortex Phellodendri 50g, Olibanum 50g, Myrrha 50g, Radix Notoginseng 50g, catechu 50g, Cortex Moutan 70g, Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) 30g, Radix Achyranthis Bidentatae 50g in proportion, be separately dried and pulverized 200 mesh sieves.The medicated powder such as Radix Et Rhizoma Rhei, Cortex Phellodendri, Cortex Moutan, Radix Achyranthis Bidentatae and Oleum sesami are soaked 24 hours with putting stirring in pot, slow fire heats to 100 DEG C, it is incubated 30 minutes, it is naturally cooling to room temperature, add the medicated powder such as Olibanum, Myrrha, Radix Notoginseng, Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani), slow fire heats to 55 DEG C, is incubated 30 minutes, and natural cooling obtains Chinese medicine composition oil preparation of the present invention.
Embodiment 6:
Weigh Radix Et Rhizoma Rhei 40g, Cortex Phellodendri 30g, Olibanum 60g, Myrrha 40g, Radix Notoginseng 60g, catechu 60g, Cortex Moutan 40g, Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) 40g, Radix Achyranthis Bidentatae 40g in proportion, be separately dried and pulverized 200 mesh sieves. The medicated powder such as Radix Et Rhizoma Rhei, Cortex Phellodendri, Cortex Moutan, Radix Achyranthis Bidentatae and Oleum sesami are soaked 24 hours with putting stirring in pot, slow fire heats to 100 DEG C, it is incubated 45 minutes, it is naturally cooling to room temperature, add the medicated powder such as Olibanum, Myrrha, Radix Notoginseng, Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani), slow fire heats to 55 DEG C, is incubated 45 minutes, and natural cooling obtains Chinese medicine composition oil preparation of the present invention.
2 clinical laboratory data
2.1 clinical datas:
Choose patient 150 example medical because of traumatic wound in June ,-2012 in October, 2009, be randomly divided into experimental group and matched group.
Experimental group 100 example, 5 years old-70 years old age, 27 years old mean age. Wound length is less than 5cm person 64 example, and wound length is more than 5cm person 36 example, and wound depth is person 70 example within 0.5cm, and wound depth is in 0.5cm-1.0cm person 30 example.
Matched group 50 example, 10 years old-68 years old age, 27 years old mean age. Wound length is less than 5cm person 35 example, and wound length is more than 5cm person 15 example, and wound depth is person 36 example within 0.5cm, and wound depth is in 0.5cm-1.0cm person 14 example.
Above patient all bleeds because wound causes open wound, pain is gone to a doctor, until recovery from illness. Two groups of patients compare from age, wound classification, damage location, sewing needle number, wound degree aspect, through X2Inspection, there was no significant difference (P > 0.05).
2.2 Therapeutic Method:
Experimental group: routinely to, after traumatic wound debridement and suturing, according to wound size clip oilpaper, being layered on equably above by the oil preparation that invention formulation embodiment 1 prepares, thickness is advisable with 0.2cm-0.4cm. Change dressings every day 1 time, until wound healing is taken out stitches.
Matched group: be operated by traumatic wound nursing routine, after wound debridement and suturing, applies alcohol gauze, every day change dressings 1 time.
2.3 experimental results:
2.3.1 two groups of hemostasis, detumescence, analgesic effects compare in Table 1.
1 liang of table group therapeutic effect
Group | Number | Bleeding stopping period (h) | Swelling time (h) | Analgesic time (h) |
Experimental group | 100 | 0.7��0.6* | 31.6��12.5* | 22.5��10.2* |
Matched group | 50 | 2.0��1.8 | 110.2��25.5 | 74.9��19.0 |
Note: * represents through X 2 test, p < 0.01.
Visible Chinese medicine composition test group of the present invention all has pole significant difference on bleeding stopping period, swelling time or analgesic time compared with matched group. Show that the present invention has good hemostasis, detumescence, analgesic effect.
2.3.2 two groups of wound infections, wound healing situations compare in Table 2.
2 liang of table group wound infection, wound healing situation
Group | Number | Wound infection | The healing of I phase | The healing of II phase |
Experimental group | 100 | 0 | 100 | 0 |
Matched group | 50 | 9 | 32 | 18 |
Note: the healing of I phase refers to that tissue repair is based on original cell, contains only a small amount of fibrous tissue, and local is without infection, hematoma or necrosis, and tissue regeneration processes is rapid, and 26S Proteasome Structure and Function reparation is good. The healing of II phase refers to that tissue defect is big, edge of wound is not whole, trembles out, cannot be neatly involutory, or the healing with the wound infected.
Wherein experimental group wound is taken out stitches as scheduled, the shortest 4 days, the longest 7 days, and matched group wounds unwinding is the shortest 5 days, the longest 40 days.Simultaneously from table 2 it can be seen that, Chinese medicine composition test group of the present invention occurs without wound infection, and I phase healing rate can reach 100%, and matched group has 9 example generation wound infections, and I phase healing rate is only 64%. Show Chinese medicine composition of the present invention can bacteriostasis antibiosis, removing the necrotic tissue and promoting granulation, accelerating wound healing.
Claims (5)
1. the Chinese medicine composition promoting wound healing, it is characterised in that the external preparation that it is made up of the raw material of following weight parts:
2. the Chinese medicine composition promoting wound healing as claimed in claim 1, it is characterised in that the external preparation that it is made up of the raw material of following weight parts:
3. the Chinese medicine composition entering wound healing as described in as arbitrary in claim 1 or 2, it is characterised in that described external preparation is paste, oil preparation or unguentum.
4. the Chinese medicine composition promoting wound healing as claimed in claim 3, it is characterised in that described external preparation is oil preparation.
5. the Chinese medicine composition promoting wound healing as claimed in claim 4, it is characterised in that its preparation method comprises the steps of
Step 1), weigh Radix Et Rhizoma Rhei, Cortex Phellodendri, Olibanum, Myrrha, Radix Notoginseng, catechu, Cortex Moutan, Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani), Radix Achyranthis Bidentatae in proportion, drying and crushing crosses 200 mesh sieves;
Step 2), Radix Et Rhizoma Rhei, Cortex Phellodendri, Cortex Moutan, Radix Achyranthis Bidentatae and Oleum sesami are soaked 12-24 hour with putting stirring in pot, slow fire heats to 80 DEG C-110 DEG C, is incubated 30-60 minute, is naturally cooling to room temperature;
Step 3), in step 2) in add the medicated powder such as Olibanum, Myrrha, Radix Notoginseng, Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani), slow fire heats to 30 DEG C-60 DEG C, is incubated 30-60 minute, and natural cooling obtains oil preparation.
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CN106237272A (en) * | 2016-03-22 | 2016-12-21 | 董永华 | A kind of external application Chinese medicine treating ulcerative carbuncle toxic swelling |
Citations (4)
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CN1089143A (en) * | 1993-01-04 | 1994-07-13 | 王富珍 | The Chinese medicine magic adhesive plaster for trauma |
CN1282605A (en) * | 1999-08-03 | 2001-02-07 | 宋国才 | Prescription and preparing process of Chinese medicine for treating burn and scald |
CN1785291A (en) * | 2004-12-10 | 2006-06-14 | 崔庆智 | Medicine for treating burn and scald and its prepartion method |
RO126090A2 (en) * | 2009-09-17 | 2011-03-30 | Liviu Andronovici | Emollient, astringent and wound healing ointment based on plant extracts |
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2012
- 2012-12-13 CN CN201210538504.XA patent/CN103181969B/en not_active Expired - Fee Related
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
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CN1089143A (en) * | 1993-01-04 | 1994-07-13 | 王富珍 | The Chinese medicine magic adhesive plaster for trauma |
CN1282605A (en) * | 1999-08-03 | 2001-02-07 | 宋国才 | Prescription and preparing process of Chinese medicine for treating burn and scald |
CN1785291A (en) * | 2004-12-10 | 2006-06-14 | 崔庆智 | Medicine for treating burn and scald and its prepartion method |
RO126090A2 (en) * | 2009-09-17 | 2011-03-30 | Liviu Andronovici | Emollient, astringent and wound healing ointment based on plant extracts |
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