CN103181969A - Chinese medicinal composition for promoting wound healing - Google Patents
Chinese medicinal composition for promoting wound healing Download PDFInfo
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Abstract
The invention belongs to the technical field of medicine and particularly discloses a Chinese medicinal composition for promoting wound healing and a preparation method thereof. The Chinese medicinal composition disclosed by the invention is prepared from rhubarb, phellodendron amurense, frankincense, myrrh, panax pseudoginseng, catecholamine, cortex moutan, aconitum szechenyianum gay, achyranthes bidentata, sesame oil and the like according to a certain proportion. The Chinese medicinal composition has effects of cooling blood and stopping bleeding, relieving swelling and pain, inhibiting bacteria and resisting to bacteria and eliminating putridity and promoting tissue regeneration and can accelerate wound healing. The preparation method of the Chinese medicinal composition, disclosed by the invention, is simple and easy to operate and is easy to popularize.
Description
Technical field
The invention belongs to technical field of Chinese medicines, be specifically related to a kind of Chinese medicine composition that promotes wound healing and preparation method thereof.
Background technology
Traumatic wound is that hospital is anxious, the modal traumatic disease of outpatient service, also is the common disease in the life.Traumatic wound belongs to the contaminative wound more, hinders in the 6 h-8 h of back, and antibacterial exists only in wound surface, still remains static, and whether treatment of wounds in time, appropriately directly has influence on wound healing.How to treat just and can palliate the agonizing sufferings, avoid wound infection, promote wound healing, the normal wound debridement and suturing that adopts applies alcohol gauze, every day or the method for changing dressings every other day in the practice.
The ancient prescription of traditional treatment surgical wound has Shengji Yuhong Gao, incised wound SHENGJISAN, rotten SHENGJISAN, putrefaction-removing granulation-promoting paste etc. to the greatest extent.
Tian Chunling is in " clinical observation of cataplasm of tcm treatment facial area wound " (" Henan College Of Traditional Chinese Medicine journal " the 20th total the 120th phase of volume, the 69th page) a kind of cataplasm of tcm is disclosed in the literary composition, prescription is Cacumen Platycladi 60g, Radix Et Rhizoma Rhei 60g, Cortex Phellodendri 30g, Pollen Typhae 30g, Rhizoma Corydalis 25g, Sanguis Draxonis 10g, Radix Sophorae Flavescentis 20g etc.; All medicated powder is broken into fine powder, the mixing that sieves, it is standby to make powder.Boil heat with water, Mel in the 4:1 ratio during use, the thick pasty state mass of furnishing, external application affected part.The side of changing has obtained excellent curative.In clinical, the thickness of covering of this mass is with 0.6cm-1.2cm, if mass is too thin, moisture runs off easily and influences the persistency of drug effect; Mass is too thick then to cause drug waste, and profile is not attractive in appearance, to causing patient's inconvenient activity.
The inventor provides a kind of Chinese medicine composition of brand-new promotion wound healing through long-term experimentation.
Summary of the invention:
The object of the present invention is to provide a kind of cooling blood for hemostasis, reducing swelling and alleviating pain, removing the necrotic tissue and promoting granulation, bacteriostasis antibiosis, promote the Chinese medicine composition of wound healing.
The present invention is achieved through the following technical solutions:
A kind of Chinese medicine composition that promotes wound healing provided by the invention is characterized in that being made by Radix Et Rhizoma Rhei, Cortex Phellodendri, Olibanum, Myrrha, Radix Notoginseng, catechu, Cortex Moutan, Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani), Radix Achyranthis Bidentatae, Semen Sesami wet goods raw material.
Preferably, a kind of Chinese medicine composition that promotes wound healing provided by the invention is characterized in that being made by the raw material of following weight portion:
Radix Et Rhizoma Rhei 40-120 weight portion Cortex Phellodendri 20-60 weight portion Olibanum 60-100 weight portion
Myrrha 30-60 weight portion Radix Notoginseng 30-60 weight portion catechu 60-100 weight portion
Cortex Moutan 40-80 weight portion Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) 20-50 weight portion Radix Achyranthis Bidentatae 30-80 weight portion
Oleum sesami 700-1200 weight portion
Most preferably, Chinese medicine composition of the present invention is made by the raw material of following weight portion:
Radix Et Rhizoma Rhei 100 weight portion Cortex Phellodendris 30 weight portion Olibanums 80 weight portions
Myrrha 40 weight portion Radix Notoginseng 60 weight portion catechu 80 weight portions
Cortex Moutan 70 weight portion Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) 40 weight portion Radix Achyranthis Bidentataes 40 weight portions
Oleum sesami 800 weight portions
Side of the present invention separates:
Radix Et Rhizoma Rhei: another name, general, yellow good, Radix Et Rhizoma Rhei etc., nature and flavor: hardship, cold.Gui Jing: stomach warp; Large intestine channel; Liver Channel; Spleen channel.Effect: attack stagnant; Clearing away damp-heat; Pathogenic fire purging; Removing heat from blood; Blood stasis dispelling; Detoxifcation.In the present invention mainly as blood-cooling hemostatic.
Cortex Phellodendri: another name, Cortex Phellodendri, Cortex Phellodendri, bark of a cork tree wood, bark of a cork tree skin.Meridian distribution of property and flavor: hardship, cold.Return kidney, bladder, large intestine channel.Function with cure mainly: heat clearing and damp drying, eliminating fire and detoxication is except the hectic fever due to YIN-deficiency clearind deficient heat.In the present invention as the clearing away heat to alleviate pain medicine.
Olibanum: another name, smoked Lu Xiang, horse hair perfume (or spice), nipple perfume (or spice) etc.Nature and flavor: arduous, temperature.Gui Jing: go into the heart, liver, spleen channel.Cure mainly: regulating qi and activating blood, analgesic therapy chases after poison.Control coagulation of QI-blood, trusted subordinate's pain, carbuncle pyogenic infections from tumour or sore, traumatic injury, dysmenorrhea, postnatal blood stasis twinge.Play the activating blood circulation to dissipate blood stasis pain relieving in the present invention.
Myrrha: another name, myrrh, bright Myrrha etc.Nature and flavor: hardship, suffering, flat.Gui Jing: go into liver, spleen, the heart, kidney channel.Control traumatic injury, incised wound, muscles and bones, all pains of trusted subordinate, lump in the abdomen, amenorrhea, ulcer sore pain, anal fistula, diseases of the eye.
Radix Notoginseng: another name, Radix Stephaniae Sinicae (Radix Stephaniae Dielsianae), Herba Wedeliae Wallichii, mountain lacquer, Radix Notoginseng, Radix Notoginseng, Yunnan Radix Notoginseng, Rhizoma Bergeniae scopulosae etc.Nature and flavor: sweet in the mouth; Little hardship; Warm in nature.Gui Jing: return Liver Channel; The stomach warp; Heart channel; Lung meridian; Large intestine channel.Function: hemostasis; Blood looses; Analgesic therapy.Cure mainly: fall and pounce on congestive edema, thoracic obstruction angor, lump in the abdomen; The blood stasis amenorrhea; Dysmenorrhea.Play the effect of activating blood circulation to dissipate blood stasis pain relieving in the present invention together altogether with Olibanum.
Catechu, another name CATECHU, Catechu, gambier.Meridian distribution of property and flavor: bitter, puckery, be slightly cold.Return lung meridian.Function cures mainly: the removing dampness promoting tissue regeneration and ulcer healing.Be used for ulcer being unable to heal, eczema, aphtha is fallen and is pounced on the pain of injury, traumatic hemorrhage.Play anastaltic effect in the present invention.
Cortex Moutan: another name, moutan root bark, Cortex Moutan, DANGEN etc.Meridian distribution of property and flavor is cold in nature, bitter in the mouth; Cool; Be slightly cold.GUIXIN; Liver; Kidney; Lung meridian.Effect cures mainly: clearing away heat and cooling blood; Promoting blood circulation to remove blood stasis.The epidemic febrile disease pathogenic heat attacking blood system in febrile diseases; Send out speckle; Tell nosebleed; The calentura later stage, hot Fu Yin divided heating; Deficiency of YIN osteopyrexia and fever; Amenorrhea due to stagnation of blood; Dysmenorrhea; Carbuncle sore tumefacting virus; Fall and pounce on the pain of injury; The rheumatism pyretic arthralgia.Play clearing away heat and cooling blood in the present invention; The effect of promoting blood circulation to remove blood stasis.
Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani): another name, iron staff mallet, three changes half.Meridian distribution of property and flavor: bitter, hot, temperature.Very toxic.Function cures mainly: anti-inflammatory analgetic, expelling wind and removing dampness.In the present invention as the narcotic analgesic medicine.
Radix Achyranthis Bidentatae: another name, Radix Achyranthis Bidentatae, cattle stem, foot this pedal, car pusher knee joint, Du's Radix Achyranthis Bidentatae, Radix Achyranthis Bidentatae etc.Gui Jing: liver; Kidney channel.Effect: invigorating the liver and kidney; Bone and muscle strengthening; Promoting blood circulation to restore menstrual flow; It is descending to ignite; Inducing diuresis for treating stranguria syndrome.
Oleum sesami: nature and flavor are sweet, cool, have the effect of loosening bowel to relieve constipation, removing toxic substances and promoting granulation.Oleum sesami is also as coordinating the actions of various ingredients in a prescription in the present invention.
Radix Et Rhizoma Rhei, Cortex Phellodendri, Olibanum, Myrrha, Radix Notoginseng, catechu, Cortex Moutan, Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani), Radix Achyranthis Bidentatae, all medicines of Semen Sesami wet goods can cooperatively interact in the Chinese medicine composition of the present invention, collaborative mutually, both can cooling blood for hemostasis, reducing swelling and alleviating pain, again can bacteriostasis antibiosis, removing the necrotic tissue and promoting granulation, finally reach the effect of accelerating wound healing.
Chinese medicine composition of the present invention can adopt the conventional method of pharmaceutical preparation to be prepared into multiple dosage forms such as oil preparation, paste, unguentum.
Be preferably oil preparation.
Another object of the present invention provides a kind of preparation method that promotes the Chinese medicine composition of wound healing, and concrete technical scheme is as follows:
(1) take by weighing Radix Et Rhizoma Rhei, Cortex Phellodendri, Olibanum, Myrrha, Radix Notoginseng, catechu, Cortex Moutan, Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani), Radix Achyranthis Bidentatae in proportion, drying and crushing is crossed 200 mesh sieves.
(2) Radix Et Rhizoma Rhei, Cortex Phellodendri, Cortex Moutan, Radix Achyranthis Bidentatae and Oleum sesami were soaked 12-24 hour with putting to stir in the pot, slow fire is heated to 80 ℃-110 ℃, is incubated 30-60 minute, is cooled to room temperature naturally.
(3) in step 2) in add medicated powder such as Olibanum, Myrrha, Radix Notoginseng, Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani), slow fire is heated to 30 ℃-60 ℃, is incubated 30-60 minute, natural cooling gets Chinese medicine composition oil preparation of the present invention.
Oil preparation of the present invention is easy to use, is external used medicine, and routinely to behind the traumatic wound debridement and suturing, according to wound size clip oilpaper, above oil preparation of the present invention was layered on equably, thickness was advisable with 0.2cm-0.4cm.Change dressings every day 1 time, take out stitches until wound healing.
The present invention is evident in efficacy, has cured example surplus the patient 600, effective percentage 100%.No valuable product among the present invention, used Chinese medicine source is sufficient, and no in great shortage, its preparation technology simply is easy to apply, and has tangible economic and social benefit.
The specific embodiment
Below will further specify the present invention by specific embodiment, but and not limit the present invention in any way.
1. FORMULATION EXAMPLE:
Embodiment 1:
Take by weighing Radix Et Rhizoma Rhei 100g, Cortex Phellodendri 30g, Olibanum 80g, Myrrha 40g, Radix Notoginseng 60g, catechu 80g, Cortex Moutan 70g, Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) 40g, Radix Achyranthis Bidentatae 40g in proportion, drying and crushing is crossed 200 mesh sieves respectively.Medicated powder such as Radix Et Rhizoma Rhei, Cortex Phellodendri, Cortex Moutan, Radix Achyranthis Bidentatae and Oleum sesami were soaked 24 hours with putting to stir in the pot, slow fire is heated to 105 ℃, be incubated 60 minutes, naturally be cooled to room temperature, add medicated powder such as Olibanum, Myrrha, Radix Notoginseng, Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani), slow fire is heated to 55 ℃, is incubated 60 minutes, and natural cooling gets Chinese medicine composition oil preparation of the present invention.
Embodiment 2:
Take by weighing Radix Et Rhizoma Rhei 40g, Cortex Phellodendri 30g, Olibanum 60g, Myrrha 30g, Radix Notoginseng 30g, catechu 60g, Cortex Moutan 40g, Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) 20g, Radix Achyranthis Bidentatae 30g in proportion, drying and crushing is crossed 200 mesh sieves respectively.Medicated powder such as Radix Et Rhizoma Rhei, Cortex Phellodendri, Cortex Moutan, Radix Achyranthis Bidentatae and Oleum sesami were soaked 18 hours with putting to stir in the pot, slow fire is heated to 100 ℃, be incubated 60 minutes, naturally be cooled to room temperature, add medicated powder such as Olibanum, Myrrha, Radix Notoginseng, Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani), slow fire is heated to 55 ℃, is incubated 60 minutes, and natural cooling gets Chinese medicine composition oil preparation of the present invention.
Embodiment 3:
Take by weighing Radix Et Rhizoma Rhei 120g, Cortex Phellodendri 60g, Olibanum 80g, Myrrha 40g, Radix Notoginseng 60g, catechu 60g, Cortex Moutan 70g, Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) 50g, Radix Achyranthis Bidentatae 80g in proportion, drying and crushing is crossed 200 mesh sieves respectively.Medicated powder such as Radix Et Rhizoma Rhei, Cortex Phellodendri, Cortex Moutan, Radix Achyranthis Bidentatae and Oleum sesami were soaked 18 hours with putting to stir in the pot, slow fire is heated to 90 ℃, be incubated 60 minutes, naturally be cooled to room temperature, add medicated powder such as Olibanum, Myrrha, Radix Notoginseng, Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani), slow fire is heated to 60 ℃, is incubated 30 minutes, and natural cooling gets Chinese medicine composition oil preparation of the present invention.
Embodiment 4:
Take by weighing Radix Et Rhizoma Rhei 120g, Cortex Phellodendri 60g, Olibanum 100g, Myrrha 60g, Radix Notoginseng 60g, catechu 100g, Cortex Moutan 80g, Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) 50g, Radix Achyranthis Bidentatae 80g in proportion, drying and crushing is crossed 200 mesh sieves respectively.Medicated powder such as Radix Et Rhizoma Rhei, Cortex Phellodendri, Cortex Moutan, Radix Achyranthis Bidentatae and Oleum sesami were soaked 24 hours with putting to stir in the pot, slow fire is heated to 110 ℃, be incubated 60 minutes, naturally be cooled to room temperature, add medicated powder such as Olibanum, Myrrha, Radix Notoginseng, Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani), slow fire is heated to 60 ℃, is incubated 60 minutes, and natural cooling gets Chinese medicine composition oil preparation of the present invention.
Embodiment 5:
Take by weighing Radix Et Rhizoma Rhei 70g, Cortex Phellodendri 50g, Olibanum 50g, Myrrha 50g, Radix Notoginseng 50g, catechu 50g, Cortex Moutan 70g, Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) 30g, Radix Achyranthis Bidentatae 50g in proportion, drying and crushing is crossed 200 mesh sieves respectively.Medicated powder such as Radix Et Rhizoma Rhei, Cortex Phellodendri, Cortex Moutan, Radix Achyranthis Bidentatae and Oleum sesami were soaked 24 hours with putting to stir in the pot, slow fire is heated to 100 ℃, be incubated 30 minutes, naturally be cooled to room temperature, add medicated powder such as Olibanum, Myrrha, Radix Notoginseng, Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani), slow fire is heated to 55 ℃, is incubated 30 minutes, and natural cooling gets Chinese medicine composition oil preparation of the present invention.
Embodiment 6:
Take by weighing Radix Et Rhizoma Rhei 40g, Cortex Phellodendri 30g, Olibanum 60g, Myrrha 40g, Radix Notoginseng 60g, catechu 60g, Cortex Moutan 40g, Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) 40g, Radix Achyranthis Bidentatae 40g in proportion, drying and crushing is crossed 200 mesh sieves respectively.Medicated powder such as Radix Et Rhizoma Rhei, Cortex Phellodendri, Cortex Moutan, Radix Achyranthis Bidentatae and Oleum sesami were soaked 24 hours with putting to stir in the pot, slow fire is heated to 100 ℃, be incubated 45 minutes, naturally be cooled to room temperature, add medicated powder such as Olibanum, Myrrha, Radix Notoginseng, Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani), slow fire is heated to 55 ℃, is incubated 45 minutes, and natural cooling gets Chinese medicine composition oil preparation of the present invention.
?
2 clinical experiment data
2.1 clinical data:
Choose patient's 150 examples of going to a doctor because of traumatic wound year June in October, 2009-2012, be divided into experimental group and matched group at random.
Experimental group 100 examples, 5 years old-70 years old age, 27 years old mean age.Wound length is less than 5cm person's 64 examples, and wound length is greater than 5cm person's 36 examples, and with interior person's 70 examples, wound depth is in 0.5cm-1.0cm person's 30 examples at 0.5cm for wound depth.
Matched group 50 examples, 10 years old-68 years old age, 27 years old mean age.Wound length is less than 5cm person's 35 examples, and wound length is greater than 5cm person's 15 examples, and with interior person's 36 examples, wound depth is in 0.5cm-1.0cm person's 14 examples at 0.5cm for wound depth.
Above patient all bleeds because wound causes open wound, pain is gone to a doctor, until recovery from illness.Two groups of patients compare from age, wound classification, damage location, sewing needle number, wound degree aspect, through X
2Check, there was no significant difference (P〉0.05).
2.2 Therapeutic Method:
Experimental group: routinely to behind the traumatic wound debridement and suturing, according to wound size clip oilpaper, above the oil preparation that FORMULATION EXAMPLE 1 of the present invention is made was layered on equably, thickness was advisable with 0.2cm-0.4cm.Change dressings every day 1 time, take out stitches until wound healing.
Matched group: operate by the traumatic wound nursing routine, behind the wound debridement and suturing, apply alcohol gauze, every day, change dressings was 1 time.
2.3 experimental result:
2.3.1 two groups of hemostasis, detumescence, analgesic effects relatively see Table 1.
Table 1 liang group therapeutic effect
Group | Number | Bleeding stopping period (h) | The detumescence time (h) | Analgesic time (h) |
Experimental group | 100 | 0.7±0.6* | 31.6±12.5* | 22.5±10.2* |
Matched group | 50 | 2.0±1.8 | 110.2±25.5 | 74.9±19.0 |
Annotate: * represents through X 2 test, p<0.01.
As seen Chinese medicine composition test group of the present invention is compared with matched group on bleeding stopping period, detumescence time still are analgesic time and is all had utmost point significant difference.Show that the present invention has good hemostasis, detumescence, analgesic effect.
2.3.2 two groups of wound infections, wound healing situations relatively see Table 2.
Table 2 liang group wound infection, wound healing situation
Group | Number | Wound infection | The healing of I phase | The healing of II phase |
Experimental group | 100 | 0 | 100 | 0 |
Matched group | 50 | 9 | 32 | 18 |
Annotate: the healing of I phase refers to that tissue repair based on original cell, only contains the small amount of fibers tissue, and local nothing infects, hematoma or necrosis, and the tissue regeneration process is rapid, and the 26S Proteasome Structure and Function reparation is good.II phase healing refers to that tissue defect is big, edge of wound is not put in order, trembles out, can't be neatly involutory, or with the healing of the wound that infects.
Wherein the experimental group wound is taken out stitches as scheduled, and is the shortest 4 days, the longest 7 days, and the matched group wounds unwinding is the shortest 5 days, the longest 40 days.Can see from table 2 that simultaneously Chinese medicine composition test group of the present invention does not have wound infection and takes place, I phase healing rate can reach 100%, and matched group has 9 examples that wound infection takes place, and I phase healing rate only is 64%.Show Chinese medicine composition of the present invention can bacteriostasis antibiosis, removing the necrotic tissue and promoting granulation, accelerating wound healing.
Claims (7)
1. a Chinese medicine composition that promotes wound healing is characterized in that being made by Radix Et Rhizoma Rhei, Cortex Phellodendri, Olibanum, Myrrha, Radix Notoginseng, catechu, Cortex Moutan, Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani), Radix Achyranthis Bidentatae and Oleum sesami.
2. a kind of Chinese medicine composition that promotes wound healing as claimed in claim 1 is characterized in that being made by the raw material of following weight parts:
Radix Et Rhizoma Rhei 40-120 weight portion Cortex Phellodendri 20-60 weight portion Olibanum 60-100 weight portion
Myrrha 30-60 weight portion Radix Notoginseng 30-60 weight portion catechu 60-100 weight portion
Cortex Moutan 40-80 weight portion Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) 20-50 weight portion Radix Achyranthis Bidentatae 30-80 weight portion
Oleum sesami 700-1200 weight portion.
3. a kind of Chinese medicine composition that promotes wound healing as claimed in claim 2 is characterized in that being made by the raw material of following weight parts:
Radix Et Rhizoma Rhei 100 weight portion Cortex Phellodendris 30 weight portion Olibanums 80 weight portions
Myrrha 40 weight portion Radix Notoginseng 60 weight portion catechu 80 weight portions
Cortex Moutan 70 weight portion Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) 40 weight portion Radix Achyranthis Bidentataes 40 weight portions
Oleum sesami 800 weight portions.
4. as the arbitrary described a kind of Chinese medicine composition that promotes wound healing of claim 1-3, it is characterized in that: described Chinese medicine composition is external preparation.
5. a kind of Chinese medicine composition that promotes wound healing as claimed in claim 4, it is characterized in that: described external preparation is
Paste, oil preparation or unguentum.
6. a kind of Chinese medicine composition that promotes wound healing as claimed in claim 5, it is characterized in that: described external preparation is oil preparation.
7. preparation method that promotes the Chinese medicine composition of wound healing is characterized in that comprising following steps:
Step 1) takes by weighing Radix Et Rhizoma Rhei, Cortex Phellodendri, Olibanum, Myrrha, Radix Notoginseng, catechu, Cortex Moutan, Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani), Radix Achyranthis Bidentatae in proportion, and drying and crushing is crossed 200 mesh sieves;
Step 2), Radix Et Rhizoma Rhei, Cortex Phellodendri, Cortex Moutan, Radix Achyranthis Bidentatae and Oleum sesami were soaked 12-24 hour with putting to stir in the pot, slow fire is heated to 80 ℃-110 ℃, is incubated 30-60 minute, is cooled to room temperature naturally;
Step 3) is in step 2) in add medicated powder such as Olibanum, Myrrha, Radix Notoginseng, Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani), slow fire is heated to 30 ℃-60 ℃, is incubated 30-60 minute, natural cooling gets Chinese medicine composition oil preparation of the present invention.
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CN106237272A (en) * | 2016-03-22 | 2016-12-21 | 董永华 | A kind of external application Chinese medicine treating ulcerative carbuncle toxic swelling |
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CN106237272A (en) * | 2016-03-22 | 2016-12-21 | 董永华 | A kind of external application Chinese medicine treating ulcerative carbuncle toxic swelling |
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