CN108379350A - A kind of eczema ointment and preparation method thereof - Google Patents
A kind of eczema ointment and preparation method thereof Download PDFInfo
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- CN108379350A CN108379350A CN201810520335.4A CN201810520335A CN108379350A CN 108379350 A CN108379350 A CN 108379350A CN 201810520335 A CN201810520335 A CN 201810520335A CN 108379350 A CN108379350 A CN 108379350A
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- eczema
- ointment
- eczema ointment
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Abstract
The invention discloses a kind of eczema ointments and preparation method thereof, including following preparation process：1) cicada slough, Radix Astragali, Radix Angelicae Sinensis, frankincense, myrrh, waist Huang and Golden Larch Bark are crushed, impregnates, is heated at reflux；Filtering obtains Chinese medical extract I after evaporating solvent；2) wormwood and mother chrysanthemum decoct, and water extract II is obtained after concentration；3) Chinese medical extract I, water extract II, lotus nut starch and honey are mixed, confection III is made；4) glycerin monostearate and Aloe Vera Gel are mixed and carries out ultrasound, heating, obtain solution IV；5) his Mack department and dispersant are merged with mixed liquor, eczema ointment coarse fodder is obtained after evaporating solvent；6) by coarse fodder it is high-pressure homogeneous after to get to eczema ointment.Eczema ointment produced by the present invention has removing dampness to stop itchin, immunological regulation, anti-inflammatory and antipruritic, clearing heart fire, mental-tranquilization, regulating the qi flowing in the channels of invigorating blood circulation relieves pain, dispersing swelling and dissipating binds myogenic, for festering caused by itch, warts, can removing necrosis, promoting granulation the effects that, and the root that can cure the disease is without any side effects.
Description
Technical field
The present invention relates to field of medicaments more particularly to a kind of eczema ointment and preparation method thereof.
Background technology
Eczema is a kind of scytitis reaction of the acute pruritus caused by a variety of internal and external factors.Eczematosis is because of complexity, often
For internal and external reasons interaction result.Internal cause for example chronic digestive system disease, stress, insomnia, over fatigue, emotional change,
Endocrine disorder, infection, dysbolism etc., external cause such as living environment, climate change, food etc. can influence the hair of eczema
It is raw.Environmental stimuli such as daylight, cold, drying, sweltering heat, hot water is scalded and various animal skins, plant, cosmetics, soap, people
Making fiber etc. can induce, and be a kind of delayed allergy caused by the inside and outside factor of complexity.
It is divided into acute, subacute, chronic three phases by skin lesion performance.Acute eczema：Skin lesion is just big for most intensive grain grains
Small papule, papulo-vesicle or phlysis, substrate flush, gradually fusion is in blocks, due to scratching, papule, papulo-vesicle or blister top
It is become apparent from apparent dotted exudation and small rotten to the corn face, blur margin, such as secondary infection, inflammation after scratching, warts, purulence can be formed
Scab, epifolliculitis, furuncle etc..Feel violent itch；After being apt to occur in head, ear, distal limbs, scrotum, crissum etc., multipair title publication.
Subacute eczema：After acute eczema inflammation mitigates, skin lesion is based on small papule, incrustation and the scales of skin that peel off, rarely seen a small amount of papulo-vesicle and gruel
It is rotten, still there is violent itch.Chronic eczema：Often switch to chronic eczema because acute, subacute eczema recurrent exerbation is not cured；Also it can open
Begin be chronic eczema, show as illing skin and thicken, infiltrate, brownish red or pigmentation, rough surface, cover the scales of skin that peel off or because
It scratches and forms a scab, feel acute pruritus, be common in shank, hand, foot, fossa cubitalis, popliteal nest, vulva, anus etc..The course of disease is indefinite, easily
Recurrence, does not recover for a long time.
The range involved according to skin lesion, eczema can be divided into limitation eczema and universal eczema two major classes.Limitation eczema：
Occur over just privileged site, you can named with position, as hand eczema, pudendum eczema, eczema of scrotum, ear eczema, breast are wet
Rash, perianal eczema, legs eczema etc..Universal eczema：Skin lesion is more, general to send out or distribute in the multiple positions of whole body, as coin is wet
Rash, autosensitization dermatitis, weary lipid eczema.
Eczematosis is because of complexity, still easy recurrent exerbation after treatment improves, hardly possible radical cure.Because respectively there is feature at clinical form and position,
Therefore medication varies with each individual.Currently, there is following three kinds of therapies：One, general control principle：Find possible inducement, such as building ring
Border, living habit, diet, hobby, thought mood etc., and whether there is or not chronic lesions and internal organs disease.Two, interior to use therapy：
It selects antihistamine antipruritic, coordinates or be used alternatingly for two kinds when necessary, universal eczema is orally available or injects glucocorticoid, but
It should not be used for a long time.Three, Topical therapy：Appropriate dosage forms and drug are selected according to skin lesion situation, acute eczema local physiological brine,
3% boric acid or 1：2000~1：The flushing of 10000 liquor potassic permanganates, soak, calamine lotion convergence, protection；It is subacute, chronic
Eczema is using suitable glucocorticoid creme, burnt oil-like formulations or immunomodulator, secondary infection person's added with antibiotic preparation.
There is following drawback according to three of the above therapy：The first prevention be only capable of by adjusting daily life work and rest,
Eating habit etc. prevents the patient for not yet suffering from eczema；Although wet to treating with the antihistamine of therapy kind in second
Rash has certain effect, but prodigious side effect can be also generated to human body, lethargic sleep and it is drowsiness be common sympton, further include headache,
Dry, eye-blurred, vomiting, constipation, diarrhea, dysuria and stimulation, some may may also suffer palpitaition, arrhythmia cordis,
Blood pressure increases, allergic reaction, dizzy, amentia, depression, and sleep disorder trembles, and twitches, hematologic disease and hepatosis,
Children's last very long is overexcited, and the negative effect that this drug generates children and over-65s adult is more
Strongly, if patient when taking the drug with other drugs or mixed food when, Different Effects may be will produce；And it is oral or
Inject glucocorticoid, be utilized glucocorticoid be in body it is particularly important it is a kind of adjust molecule, its hair to body
It educates, grow, being metabolized and immune function etc. plays important regulative, being the most important adjusting hormone of Systemic stress response, but
It is oral or injects improper, glucocorticoid can brings following common side effect and harm to human body：Central obesity, blood glucose
It increases, gastric ulcer, hypertension, osteoporosis, excited, insomnia, rattiness symptom occurs in spirit, inhibits immune, skin occurs
There is glaucoma, cataract etc. in acne, crinosity, blue spot, eyes；The third, is although calamine lotion does not have apparent side effect,
But when being fully recovered soon using calamine lotion number excessive (normal condition lower day 3-4 times) or fash daily, skin can be felt
It is very tight；Hair position is unusable, and hair is avoided to lump；If largely exudation, rotten to the corn, incrustation position should not also make at skin
With；Therefore can be relatively more using the limitation of calamine lotion convergence, protection, and effect is not too much apparent；The third is mainly used
The Topical therapy of glucocorticoid creme, burnt oil-like formulations or immunomodulator is smeared in eczema affected part, existing for existing market
Tacrolimus paste, pimecrolimus ointment are long with healing time, adverse reaction is more, easy anaphylaxis skin is unusable, cure
It the limitations such as can also recur afterwards.
Invention content
It is an object of the invention to overcome the deficiencies of the prior art and provide a kind of eczema ointment and preparation method thereof, with
It solves drug side-effect great Yi existing in the prior art and causes that human body other complication, healing time are long, adverse reaction is more, easy
Anaphylaxis skin is unusable, cure after the technical problems such as can also recur.
The invention discloses following technical schemes；A kind of eczema ointment, including following raw material components：Wormwood, mother chrysanthemum, cicada
Slough off, tacrolimus, Radix Astragali, lotus seeds, Radix Angelicae Sinensis, honey, frankincense, myrrh, waist Huang, Golden Larch Bark, dispersant, glycerin monostearate and
Aloe Vera Gel；Wherein, the weight content of each raw material component is：
Further, in order to make the drug effect of each raw material component play optimum efficiency, the weight content of each raw material component is：
Further, to make dispersant have excellent physiological inertia, it is not involved in human metabolism, and there is excellent life
Object compatibility does not form human skin any stimulation, and dispersant selects polyvinylpyrrolidone, in order to make eczema medicine obtained
Cream can lotion fine and smooth lubricious, glycerin monostearate and Aloe Vera Gel are according to mass ratio 2:1 carries out mixture.
Wherein, drug effect of each raw material component played in ointment of the present invention is as follows：
Wormwood has the function of restraining and sterilizing bacteria, has very strong inhibiting effect to a variety of pathogenic dermatophytes, can treat
Multiple dermatosis, folium artemisiae argyi decoction external application can control wet sore mange, removing dampness to stop itchin, the substances such as volatile oil contained in folium artemisiae argyi, can be very
Good prevention and improvement eczema symptom.
Mother chrysanthemum, contains volatile oil, containing alantol, chrysanthanone, α-firpene, camphor, borneol, lauro lene etc. in oil, still lactone containing chrysanthemum,
The diseases such as scabies, dark sore are had very strong curative effect by chrysanthemum element A, acaciin, linarin, chrysanthemum glucoside, cyanidenon, energy wind-dispelling removing toxic substances.
Cicada slough can control measles without adequate eruption, rubella itch.
Tacrolimus, treatment chronic eczema have Immunosuppressant therapy, anti-inflammatory and itching-relieving action.Tacrolimus is immune
Conditioning agent, structure system macrolides have the characteristics that relative molecular mass is small, percutaneous permeability is good, are suitable for external application.It is made
It with mechanism is combined with the cytoplasmic protein of T lymphocytes, inhibits the phosphate esterase active of calcineurin, and then inhibit
The expression and release of cytokine profiles and inflammatory mediator, generate powerful anti-inflammatory effect；It can promote the conjunction of skin collagen simultaneously
At the recovery with skin barrier function.The anti-inflammatory effect of the medicine both alternative steroids preparation, in turn avoids long-term external application hormone
Adverse reaction caused by preparation.Tacrolimus paste is macrolides external application immunomodulator, treatment atopic dermatitis safety
Effectively.
Radix Astragali is common help class Chinese medicine, the work(with tonifying Qi and lifting yang, strengthening exterior and reducing sweat, torr sore myogenic, diuresis detumescence
Effect.Contain sucrose, glucuronic acid, a variety of amino acid, folic acid and various trace elements in Radix Astragali, has stimulating central nervous system, carries
The phagocytic function of high leukocytic and reticuloendothelial system, be improved body immunity, expansion blood vessel, improve skin blood cycle,
A variety of effects such as diuresis are given birth to Radix Astragali and are focused on outside up to skin, and hidroschesis consolidates table, torr sore myogenic.According to clinical verification, to some skin diseases
It is effective in cure.
Lotus seeds have the effect of clearing heart fire, mental-tranquilization, especially have fine curative effect to damp and hot caused eczema.
Radix Angelicae Sinensis, containing volatile oil, esters, Yan acid, retinoid etc., angelica extract can reduce vasopermeability, inhibit to cause
The release of scorching substance, to play anti-inflammatory effect.Radix Angelicae Sinensis decoction has inhibiting effect to various bacteria, and can promote immunity of organism
Function.
Honey contains 0.1%~0.4% ablastins, can inhibit the growth of bacterium, be applied on human skin, can
With antibacterial, wound infection is prevented, moreover it is possible to promote skin growth, help wound healing.
Frankincense, also name horse hair is fragrant, nipple is fragrant, bathes perfume (or spice) etc., the arduous temperature of nature and flavor enters the heart, liver, the spleen channel, and function promoting blood circulation regulating the qi flowing in the channels stops
Bitterly, dispersing swelling and dissipating binds myogenic, frankincense grind to the powder external application, do not close up long after can treating blister ulcer ulceration, can removing necrosis, promoting granulation.The present invention's
Frankincense is added in eczema ointment can effectively treat because of the infection that eczema scratches rear apparent dotted exudation and small rotten to the corn face is caused, scorching
Disease is apparent, therefore warts, purulence scab, epifolliculitis, the furuncle etc. formed.
Myrrh has the effect of scattered stasis pain, detumescence and promoting granulation；It can enhance promoting blood circulation ability with frankincense, be usually used in promoting blood circulation and stopping pain,
Ulcer sores are treated, it can swelling and pain relieving；The Radix Angelicae Sinensis being equipped with again in we can treat acute skin infection, such as carbuncle furuncle, erysipelas；It is right
Eczema curative effect that the present invention is directed to it is further preferred that.
Waist is yellow, also known as " realgar ", " orpiment ", " bright hero ", " red orpiment ", the desinsection that can detoxify, eliminating dampness, antipruritic, corruption of dispelling, and cures mainly slow
The skin diseases such as property eczema, herpes zoster, fungal infection.
Golden Larch Bark is the bark or root skin of pinaceae plant golden larch, and Golden Larch Bark has desinsection antipruritic, control tinea itch, eczema,
The effect of leprosy dysentery head, neurodermatitis.
Polyvinylpyrrolidone has excellent physiological inertia, is not involved in human metabolism, and have excellent biofacies
Capacitive does not form any stimulation to skin, mucous membrane, eye etc., and polyvinylpyrrolidone is added in this side can prevent the heavy of particle
Drop and cohesion, make each raw material component preferably be fused into emulsifiable paste shape.
Glycerin monostearate is a kind of surfactant of nonionic.It is existing hydrophilic and has lipophilic group, has
The multiple functions such as wetting, emulsification, blistering, are used as emulsifier in medical paste, and lotion can be made fine and smooth, lubricious.
Aloe Vera Gel is product made of extraction in a kind of natural herbs " aloe ", and purity is very high, nontoxic secondary to make
With it festers to incised wound, scratch, scald, wound, operative scar etc. has apparent booster action, also has good anti-inflammatory
Disinfecting and beauty effect, safe and reliable, Aloe Vera Gel is added in the ointment component of the present invention can promote to scald skin histology
Restore, avoids scar.
The invention discloses a kind of preparation methods of eczema ointment, including following preparation process：
1) yellow cicada slough, Radix Astragali, Radix Angelicae Sinensis, frankincense, myrrh, waist and Golden Larch Bark are weighed and carries out co-grinding, will be mixed after crushing
It closes object to pour into the alcohol solution dipping 24 hours for being 75~80% with mass concentration in beaker, mixture is then transferred to three again
It is heated at reflux in mouth flask；Filtering retains filtrate, and Chinese medical extract I is obtained after evaporating solvent；
2) it weighs the wormwood after drying and mother chrysanthemum is put into pot and is decocted with clear water, after small fire boiling decocts 2~3 hours, fishing
Wormwood and mother chrysanthemum, aqueous is taken to obtain water extract II after concentration；
3) Chinese medical extract I and water extract II are put into beaker and are merged, and the lotus seeds pulverized and honey are fallen
Enter in beaker and is mixed；Obtain confection III；
4) it glycerin monostearate and Aloe Vera Gel is poured into another is contained in the beaker of absolute ethyl alcohol and mix, and will mix
It closes solution and is put into progress ultrasound, heating in Ultrasound Instrument；After being sufficiently mixed, solution IV is obtained；
5) his load weighted Mack department and dispersant are added in confection III, while again fall solution IV obtained
Enter in confection III, be mixed, eczema ointment coarse fodder is obtained after evaporating solvent；
6) eczema ointment coarse fodder is injected in high pressure homogenizer carry out it is high-pressure homogeneous, to get to eczema medicine after aluminium suitcase dress
Cream.
Further, in order to keep cicada slough, Radix Astragali, Radix Angelicae Sinensis, frankincense, myrrh, waist yellow and the active ingredient of Golden Larch Bark is more preferable
Extraction, while in order to avoid because temperature is excessively high and heating time long influence drug effect, the temperature control being heated at reflux in step 1)
System is at 85~90 DEG C, and the time control of reflux was at 2~3 hours.
Further, in order to keep ointment lotion made from the later stage uniform, consistency is suitable, the water extraction in step 2) after concentration
II fixing fabric structure of object is in 10~15mm.
Further, in order to keep ointment lotion made from the later stage uniform, being not in particle precipitation influences to use, step 3)
In the lotus seeds pulverized cross 120 mesh screens.
Further, in order to make IV uniform and smooth of solution obtained, ultrasonic time control is at 15~30 points in step 4)
The temperature of clock, heating is controlled at 40 DEG C.
Further, purer in order to make to be made ointment quality, remaining solvent in it is removed completely, it will in step 5)
Solution IV obtained pours into confection III, is put into after mixing in vacuum drying chamber and carries out evaporation of the solvent, vacuum degree control
System is controlled in 0.3~0.5 atmospheric pressure, temperature at 50~55 DEG C.
Eczema ointment has the advantages that made from preparation method of the present invention：Removing dampness to stop itchin, immunological regulation, it is anti-inflammatory and
Antipruritic, clearing heart fire, mental-tranquilization, promoting blood circulation regulating the qi flowing in the channels analgesic, dispersing swelling and dissipating binds myogenic can for festering caused by itch, warts
Removing necrosis, promoting granulation.Again because eczema is a kind of allergic disease (allergic reaction), after body's immunity is by destroying, body
The allergin in blood cannot be removed, it is anti-that these allergins adhere to the metamorphosis caused on dermovascular basilar memebrane
It answers.Eczema ointment produced by the present invention mainly uses traditional Chinese medicine ingredients as raw material, and middle the effective elements of the medicine is all that some are organic
The macromolecular of object, it contains many active groups, can adhere to the allergin in blood, forms the compound of bigger, this
Compound is excreted by the diuresis of Chinese medicine from kidney, so the phenomenon that treatment of eczema is not in repeatedly, and its
Chinese medicine in middle each raw material component is plant mostly, seldom can suffer from the patient of eczema for a long time there is a phenomenon where damage liver kidney,
Smearing the eczema ointment of the present invention can cure the disease root, and will not bring any side effect.
Specific implementation mode
It elaborates below to the embodiment of the present invention, the present embodiment is carried out lower based on the technical solution of the present invention
Implement, gives detailed embodiment and specific operating process, but protection scope of the present invention is not limited to following implementation
Example.
Embodiment 1
Present embodiment discloses a kind of eczema ointments, including following raw material components for embodiment 1：Wormwood, mother chrysanthemum, cicada slough, he
Ke Mosi, Radix Astragali, lotus seeds, Radix Angelicae Sinensis, honey, frankincense, myrrh, waist Huang, Golden Larch Bark, dispersant, glycerin monostearate and aloe
Glue；
Wherein, the weight content of each raw material component is：
Wherein, dispersant is polyvinylpyrrolidone, and glycerin monostearate and Aloe Vera Gel are according to mass ratio 2:1 carries out
Mixture.
Present embodiment discloses a kind of preparation methods of eczema ointment, including following preparation process：
1) yellow cicada slough, Radix Astragali, Radix Angelicae Sinensis, frankincense, myrrh, waist and Golden Larch Bark are weighed and carries out co-grinding, will be mixed after crushing
It closes object to pour into the alcohol solution dipping 24 hours for being 75% with mass concentration in beaker, mixture is then transferred to three mouthfuls of burnings again
It is heated at reflux in bottle；Filtering retains filtrate, and Chinese medical extract I is obtained after evaporating solvent；
2) it weighs the wormwood after drying and mother chrysanthemum is put into pot and is decocted with clear water, after small fire boiling decocts 2 hours, fish for Chinese mugwort
Grass and mother chrysanthemum, aqueous obtain water extract II after concentration；
3) Chinese medical extract I and water extract II are put into beaker and are merged, and the lotus seeds pulverized and honey are fallen
Enter in beaker and is mixed；Obtain confection III；
4) it glycerin monostearate and Aloe Vera Gel is poured into another is contained in the beaker of absolute ethyl alcohol and mix, and will mix
It closes solution and is put into progress ultrasound, heating in Ultrasound Instrument；After being sufficiently mixed, solution IV is obtained；
5) his load weighted Mack department and dispersant are added in confection III, while again fall solution IV obtained
Enter in confection III, be mixed, eczema ointment coarse fodder is obtained after evaporating solvent；
6) eczema ointment coarse fodder is injected in high pressure homogenizer carry out it is high-pressure homogeneous, to get to eczema medicine after aluminium suitcase dress
Cream.
Wherein, at 85 DEG C, the time of reflux is 2 hours for the temperature control being heated at reflux in step 1).
Wherein, II fixing fabric structure of water extract in step 2) after concentration is in 10mm.
Wherein, the lotus seeds pulverized in step 3) cross 120 mesh screens.
Wherein, at 15 minutes, the temperature of heating was controlled at 40 DEG C time control ultrasonic in step 4).
Wherein, solution IV obtained is poured into confection III in step 5), vacuum drying chamber is put into after mixing
Middle carry out evaporation of the solvent, vacuum degree control are controlled in 0.3 atmospheric pressure, temperature at 50 DEG C.
Embodiment 2
Present embodiment discloses a kind of eczema ointments, including following raw material components for embodiment 2：Wormwood, mother chrysanthemum, cicada slough, he
Ke Mosi, Radix Astragali, lotus seeds, Radix Angelicae Sinensis, honey, frankincense, myrrh, waist Huang, Golden Larch Bark, dispersant, glycerin monostearate and aloe
Glue；Wherein, the weight content of each raw material component is：
Wherein, dispersant is polyvinylpyrrolidone, and glycerin monostearate and Aloe Vera Gel are according to mass ratio 2:1 carries out
Mixture.
Present embodiment discloses a kind of preparation methods of eczema ointment, including following preparation process：
1) yellow cicada slough, Radix Astragali, Radix Angelicae Sinensis, frankincense, myrrh, waist and Golden Larch Bark are weighed and carries out co-grinding, will be mixed after crushing
It closes object to pour into the alcohol solution dipping 24 hours for being 80% with mass concentration in beaker, mixture is then transferred to three mouthfuls of burnings again
It is heated at reflux in bottle；Filtering retains filtrate, and Chinese medical extract I is obtained after evaporating solvent；
2) it weighs the wormwood after drying and mother chrysanthemum is put into pot and is decocted with clear water, after small fire boiling decocts 3 hours, fish for Chinese mugwort
Grass and mother chrysanthemum, aqueous obtain water extract II after concentration；
3) Chinese medical extract I and water extract II are put into beaker and are merged, and the lotus seeds pulverized and honey are fallen
Enter in beaker and is mixed；Obtain confection III；
4) it glycerin monostearate and Aloe Vera Gel is poured into another is contained in the beaker of absolute ethyl alcohol and mix, and will mix
It closes solution and is put into progress ultrasound, heating in Ultrasound Instrument；After being sufficiently mixed, solution IV is obtained；
5) his load weighted Mack department and dispersant are added in confection III, while again fall solution IV obtained
Enter in confection III, be mixed, eczema ointment coarse fodder is obtained after evaporating solvent；
6) eczema ointment coarse fodder is injected in high pressure homogenizer carry out it is high-pressure homogeneous, to get to eczema medicine after aluminium suitcase dress
Cream.
Wherein, at 90 DEG C, the time of reflux is 3 hours for the temperature control being heated at reflux in step 1).
Wherein, II fixing fabric structure of water extract in step 2) after concentration is in 15mm.
Wherein, the lotus seeds pulverized in step 3) cross 120 mesh screens.
Wherein, at 30 minutes, the temperature of heating was controlled at 40 DEG C time control ultrasonic in step 4).
Wherein, solution IV obtained is poured into confection III in step 5), vacuum drying chamber is put into after mixing
Middle carry out evaporation of the solvent, vacuum degree control are controlled in 0.5 atmospheric pressure, temperature at 55 DEG C.
Embodiment 3
Present embodiment discloses a kind of eczema ointments, including following raw material components for embodiment 3：Wormwood, mother chrysanthemum, cicada slough, he
Ke Mosi, Radix Astragali, lotus seeds, Radix Angelicae Sinensis, honey, frankincense, myrrh, waist Huang, Golden Larch Bark, dispersant, glycerin monostearate and aloe
Glue；Wherein, the weight content of each raw material component is：
Wherein, dispersant is polyvinylpyrrolidone, and glycerin monostearate and Aloe Vera Gel are according to mass ratio 2:1 carries out
Mixture.
Present embodiment discloses a kind of preparation methods of eczema ointment, including following preparation process：
1) yellow cicada slough, Radix Astragali, Radix Angelicae Sinensis, frankincense, myrrh, waist and Golden Larch Bark are weighed and carries out co-grinding, will be mixed after crushing
It closes object to pour into the alcohol solution dipping 24 hours for being 78% with mass concentration in beaker, mixture is then transferred to three mouthfuls of burnings again
It is heated at reflux in bottle；Filtering retains filtrate, and Chinese medical extract I is obtained after evaporating solvent；
2) it weighs the wormwood after drying and mother chrysanthemum is put into pot and is decocted with clear water, after small fire boiling decocts 3 hours, fish for Chinese mugwort
Grass and mother chrysanthemum, aqueous obtain water extract II after concentration；
3) Chinese medical extract I and water extract II are put into beaker and are merged, and the lotus seeds pulverized and honey are fallen
Enter in beaker and is mixed；Obtain confection III；
4) it glycerin monostearate and Aloe Vera Gel is poured into another is contained in the beaker of absolute ethyl alcohol and mix, and will mix
It closes solution and is put into progress ultrasound, heating in Ultrasound Instrument；After being sufficiently mixed, solution IV is obtained；
5) his load weighted Mack department and dispersant are added in confection III, while again fall solution IV obtained
Enter in confection III, be mixed, eczema ointment coarse fodder is obtained after evaporating solvent；
6) eczema ointment coarse fodder is injected in high pressure homogenizer carry out it is high-pressure homogeneous, to get to eczema medicine after aluminium suitcase dress
Cream.
Wherein, at 88 DEG C, the time of reflux is 3 hours for the temperature control being heated at reflux in step 1).
Wherein, II fixing fabric structure of water extract in step 2) after concentration is in 13mm.
Wherein, the lotus seeds pulverized in step 3) cross 120 mesh screens.
Wherein, at 25 minutes, the temperature of heating was controlled at 40 DEG C time control ultrasonic in step 4).
Wherein, solution IV obtained is poured into confection III in step 5), vacuum drying chamber is put into after mixing
Middle carry out evaporation of the solvent, vacuum degree control are controlled in 0.4 atmospheric pressure, temperature at 53 DEG C.
Embodiment 4
Present embodiment discloses a kind of eczema ointments, including following raw material components for embodiment 4：Wormwood, mother chrysanthemum, cicada slough, he
Ke Mosi, Radix Astragali, lotus seeds, Radix Angelicae Sinensis, honey, frankincense, myrrh, waist Huang, Golden Larch Bark, dispersant, glycerin monostearate and aloe
Glue；Wherein, the weight content of each raw material component is：
Wherein, dispersant is polyvinylpyrrolidone, and glycerin monostearate and Aloe Vera Gel are according to mass ratio 2:1 carries out
Mixture.
Present embodiment discloses a kind of preparation methods of eczema ointment, including following preparation process：
1) yellow cicada slough, Radix Astragali, Radix Angelicae Sinensis, frankincense, myrrh, waist and Golden Larch Bark are weighed and carries out co-grinding, will be mixed after crushing
It closes object to pour into the alcohol solution dipping 24 hours for being 76% with mass concentration in beaker, mixture is then transferred to three mouthfuls of burnings again
It is heated at reflux in bottle；Filtering retains filtrate, and Chinese medical extract I is obtained after evaporating solvent；
2) it weighs the wormwood after drying and mother chrysanthemum is put into pot and is decocted with clear water, after small fire boiling decocts 2 hours, fish for Chinese mugwort
Grass and mother chrysanthemum, aqueous obtain water extract II after concentration；
3) Chinese medical extract I and water extract II are put into beaker and are merged, and the lotus seeds pulverized and honey are fallen
Enter in beaker and is mixed；Obtain confection III；
4) it glycerin monostearate and Aloe Vera Gel is poured into another is contained in the beaker of absolute ethyl alcohol and mix, and will mix
It closes solution and is put into progress ultrasound, heating in Ultrasound Instrument；After being sufficiently mixed, solution IV is obtained；
5) his load weighted Mack department and dispersant are added in confection III, while again fall solution IV obtained
Enter in confection III, be mixed, eczema ointment coarse fodder is obtained after evaporating solvent；
6) eczema ointment coarse fodder is injected in high pressure homogenizer carry out it is high-pressure homogeneous, to get to eczema medicine after aluminium suitcase dress
Cream.
Wherein, at 86 DEG C, the time of reflux is 2 hours for the temperature control being heated at reflux in step 1).
Wherein, II fixing fabric structure of water extract in step 2) after concentration is in 12mm.
Wherein, the lotus seeds pulverized in step 3) cross 120 mesh screens.
Wherein, at 20 minutes, the temperature of heating was controlled at 40 DEG C time control ultrasonic in step 4).
Wherein, solution IV obtained is poured into confection III in step 5), vacuum drying chamber is put into after mixing
Middle carry out evaporation of the solvent, vacuum degree control are controlled in 0.3 atmospheric pressure, temperature at 52 DEG C.
One, for the clinical test of eczema patients.
1, subjects：250 eczema patients, man 165, female 85.
2, therapy
250 eczema patients are divided by treatment group's (totally four groups of Examples 1 to 4) and control group using the principle of parallel control
(totally one group), every group of 50 patients.
Through statistical analysis, each group Gender, age, the course of disease, the there was no significant difference (P such as grading>0.05), have
There is comparativity.
Treatment group：After being dried within 5 minutes with warm water's immersion affected part, eczema ointment produced by the present invention is smeared in affected part, often
Day 2 times, once in the morning and once at night.
Control group：The wet clear white skin care moisturizing rash cream in shop of painting ring, application method and the same treatment group of the frequency.
3, criterion：
(1) effective：Symptom disappears at eczema, and skin heals completely, no scar；
(2) effectively：Cardinal symptom disappears, and eczema affected part skin heals substantially, there is slight trace；
(3) invalid：Eczema symptom is not improved.
Data after contrast test are recorded, the affected part number of days used that fully recovers is fewer, rehabilitation people in same time
Number more at most drug effect is better.
4, result on trial：It is shown in Table 1.
Table 1
The data that are recorded by table 1 are it is found that behind the eczema ointment coating affected part that the present invention is prepared, in three weeks, patient
Illness all disappear, skin heals completely at eczema, and the ointment slowly effect in control group, and need application healing time compared with
It is long, and found in later stage long-term observation, the same affected part of some patients is also reoccurred the illness of the eczema.
Two, typical case：
Huang, man, 57 years old, first visit on March 20 in 2012, both hands eczema recurrent exerbation more than 6 years, patient's both hands kermesinus
Papule, itch flowing water, the apparent scratch in surface, skin lesion concomitant fertilizer in part is thick, and symptom slightly subtracts after hormone, the treatment of calcium agent antiallergic,
But it recurs quickly.Once it was diagnosed as " chronic eczema " in local hospital, through with the various therapies of traditional Chinese and western medicine Orally taken and externally, failing to control
More, frequent recurrent exerbation, it is touching not to be cured.Tongue nature is light, moss thin yellow, soft and thready pulse number.Card belongs to retention of damp-heat in the interior, and weight in wet base is in heat.Read preceding doctor
Zhu Fangduozhi is with eliminating dampness and heat, the agent of strengthening spleen and nourishing blood wind-dispelling.Patient with weak shortness of breath, may often consume with the medicine impairment of the spleen of the clear profit of informal dress
Gas is related.Control suitable QI invigorating wind-dispelling, clearing damp heat-clearing.It smears eczema ointment prepared by the present invention to fully recover after three weeks, and in later observations
One month in occur without any erythema and pruritis.
The Qin, female, 35 years old, government functionary need to often go out, and belong to easy allergic skin, especially in spring and summer season, neck and
Often there is the erythema of most intensive grain grain sizes in the back of the hand, and substrate flush, gradually fusion is in blocks, and itch is hard to bear, the water in erythema
After blister point is scratched, pus outflow causes eczema area to infect bigger, anti-inflammatory ointment can be also smeared when occurring eczema symptom before,
Scratchiness can be mitigated and further deteriorated, but can not be eradicated, after smearing eczema ointment prepared by the present invention, recovery from illness in two weeks,
Continue to smear one week, symptom is eradicated completely, and is observed in 1 year later, is not recurred again.
Lee, man, 45 years old, is engaged in agriculture, and because managing labor service for a long time and not maintained, brothers are easy under hygrothermal environment
Eczema, medical history 2 years are recurred, symptom is the back of the hand portion and instep rough surface, covers the scales of skin that peel off, feels acute pruritus, smears the present invention
After the eczema ointment of preparation, recovery from illness in two weeks, and observed in 1 year later, it does not recur again.
Guo, man, 29 years old, calf eczema recurrent exerbation more than 2 years, in the damp and hot weather of spring and summer, patient's calf affected part was risen
Kermesinus papule, pachyderma, itch smear eczema ointment prepared by the present invention and are completely recovered after three weeks, and in later observations
One month in occur without any erythema and pruritis.
The eczema ointment of the present invention is well-established by neighbouring group at present, after smearing can removing dampness to stop itchin, it is immunological regulation, anti-
It is scorching and antipruritic, clearing heart fire, mental-tranquilization, promoting blood circulation regulating the qi flowing in the channels analgesic, dispersing swelling and dissipating binds myogenic, for bursting caused by itch, warts
It is rotten, it can removing necrosis, promoting granulation.Eczema ointment produced by the present invention mainly uses traditional Chinese medicine ingredients as raw material, and middle the effective elements of the medicine is all
It is the macromolecular of some organic matters, it contains many active groups, can adhere to the allergin in blood, forms answering for bigger
Object is closed, this compound is excreted by the diuresis of Chinese medicine from kidney, so the treatment of eczema is not in repeatedly
Phenomenon, and the Chinese medicine wherein in each raw material component is plant mostly, seldom can for a long time be suffered from wet there is a phenomenon where damaging liver kidney
The patient of rash, smearing the eczema ointment of the present invention can cure the disease root, and will not bring any side effect.
Claims (9)
1. a kind of eczema ointment, which is characterized in that including following raw material components：Wormwood, mother chrysanthemum, cicada slough, tacrolimus, Radix Astragali,
Lotus seeds, Radix Angelicae Sinensis, honey, frankincense, myrrh, waist Huang, Golden Larch Bark, dispersant, glycerin monostearate and Aloe Vera Gel；Wherein, described
The weight content of each raw material component is：
2. eczema ointment as described in claim 1, which is characterized in that the weight content of each raw material component is：
3. eczema ointment as described in claim 1, which is characterized in that the dispersant is polyvinylpyrrolidone, the list
Tristerin and Aloe Vera Gel are according to mass ratio 2:1 carries out mixture.
4. a kind of preparation method of the eczema ointment as described in claim 1-3 is any, which is characterized in that walked including following preparation
Suddenly：
1) yellow cicada slough, Radix Astragali, Radix Angelicae Sinensis, frankincense, myrrh, waist and Golden Larch Bark are weighed and carries out co-grinding, by mixture after crushing
The alcohol solution dipping 24 hours for being 75~80% with mass concentration in beaker is poured into, mixture is then transferred to three mouthfuls of burnings again
It is heated at reflux in bottle；Filtering retains filtrate, and Chinese medical extract I is obtained after evaporating solvent；
2) it weighs the wormwood after drying and mother chrysanthemum is put into pot and is decocted with clear water, after small fire boiling decocts 2~3 hours, fish for Chinese mugwort
Grass and mother chrysanthemum, aqueous obtain water extract II after concentration；
3) Chinese medical extract I and water extract II are put into beaker and are merged, and the lotus seeds pulverized and honey are poured into burning
It is mixed in cup；Obtain confection III；
4) it glycerin monostearate and Aloe Vera Gel is poured into another is contained in the beaker of absolute ethyl alcohol and mix, and will be described mixed
It closes solution and is put into progress ultrasound, heating in Ultrasound Instrument；After being sufficiently mixed, solution IV is obtained；
5) his load weighted Mack department and dispersant are added in the confection III, while again fall solution IV obtained
Enter in the confection III, be mixed, eczema ointment coarse fodder is obtained after evaporating solvent；
6) the eczema ointment coarse fodder is injected in high pressure homogenizer carry out it is high-pressure homogeneous, to get to eczema medicine after aluminium suitcase dress
Cream.
5. the preparation method of eczema ointment as claimed in claim 4, which is characterized in that the temperature control being heated at reflux in step 1)
At 85~90 DEG C, the time of reflux is 2~3 hours.
6. the preparation method of eczema ointment as claimed in claim 4, which is characterized in that the water extract II in step 2) after concentration
Fixing fabric structure is in 10~15mm.
7. the preparation method of eczema ointment as claimed in claim 4, which is characterized in that the lotus seeds mistake pulverized in step 3)
120 mesh screens.
8. the preparation method of eczema ointment as claimed in claim 4, which is characterized in that ultrasonic time control is 15 in step 4)
~30 minutes, the temperature of heating was controlled at 40 DEG C.
9. the preparation method of eczema ointment as claimed in claim 4, which is characterized in that pour into solution IV obtained in step 5)
It is put into confection III, after mixing in vacuum drying chamber and carries out evaporation of the solvent, vacuum degree control is big at 0.3~0.5
Air pressure, temperature are controlled at 50~55 DEG C.
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|---|---|---|---|---|
| CN108355042A (en) * | 2018-05-28 | 2018-08-03 | 陈雨薇 | A kind of anti-inflammatory analgetic ointment and preparation method thereof |
| CN108355125A (en) * | 2018-05-28 | 2018-08-03 | 陈雨薇 | Anti- chap ointment of one kind and preparation method thereof |
| CN113476295A (en) * | 2021-02-01 | 2021-10-08 | 广西励领农业科技有限公司 | Intelligent infrared ultrasonic moxibustion instrument device and physiotherapy method |
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Cited By (3)
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| CN108355042A (en) * | 2018-05-28 | 2018-08-03 | 陈雨薇 | A kind of anti-inflammatory analgetic ointment and preparation method thereof |
| CN108355125A (en) * | 2018-05-28 | 2018-08-03 | 陈雨薇 | Anti- chap ointment of one kind and preparation method thereof |
| CN113476295A (en) * | 2021-02-01 | 2021-10-08 | 广西励领农业科技有限公司 | Intelligent infrared ultrasonic moxibustion instrument device and physiotherapy method |
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Application publication date: 20180810 |