CN108837085A - A kind of poison expelling capsule and preparation method thereof - Google Patents
A kind of poison expelling capsule and preparation method thereof Download PDFInfo
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- CN108837085A CN108837085A CN201810520359.XA CN201810520359A CN108837085A CN 108837085 A CN108837085 A CN 108837085A CN 201810520359 A CN201810520359 A CN 201810520359A CN 108837085 A CN108837085 A CN 108837085A
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
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- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
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- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/191—Carboxylic acids, e.g. valproic acid having two or more hydroxy groups, e.g. gluconic acid
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- A61K31/201—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having one or two double bonds, e.g. oleic, linoleic acids
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- A61K31/202—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having three or more double bonds, e.g. linolenic
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Abstract
The invention discloses a kind of poison expelling capsule and preparation method thereof, one, crush fructus lycii, Radix Astragali, ginseng, aloe and ginkgo leaf, soaked in absolute ethyl alcohol is heated at reflux, and is filtered, and ethanol extract I is made；Filter cake is heated at reflux again, and filtering obtains ethanol extract II；Ethanol extract I and II is spin-dried for solvent, obtains Chinese medical extract；Two, carrot, sweet potato and soybean pulverize and sieve, and diet material is made in drying；Three, Chinese medical extract, diet material, organic calcium, magnesium stearate, tea polyphenols, rice flour, maltodextrin and unsaturated fatty acid stir in the pasty state；Four, the mixed material in three is high-pressure homogeneous, dry, crush again, being sieved is made microsphere particle shape medicinal powder, is fitted into capsulae vacuus, obtained poison expelling capsule；Five, capsule polishing, packaging.Poison expelling capsule prepared by the present invention uses Chinese medicine for formula, and qi and activate blood circulation, catharsis and toxin expelling, row mends and takes into account, without side-effects, and produces that preparation process is simple, and it is low to prepare cost of material price, convenient for promoting.
Description
Technical field
The present invention relates to field of medicaments more particularly to a kind of poison expelling capsule and preparation method thereof.
Background technique
Vivotoxin is discharged, is always the health rule that Chinese medicine is advocated." row " of Chinese medicine, " solution ", " tune ", four kinds of " benefit "
Treatment method is the sequence of " toxin expelling gets rid of illness ".Toxin expelling is human circulation metabolism, obtains newborn important link, very heavy
It wants.Chinese medicine thinks that thing extra in body is known as poison, dredging enteron aisle, urethra, blood vessel, tracheae, sweat gland etc., the road Shi Ge toxin expelling pipe
Road is unobstructed, is exactly toxin expelling in order to carry out " internal general cleaning ".
Some common toxin expelling methods:1. cathartic：Cause cylinder electrolyte uneven, is lost endotrophic.There is dependence,
Long enteron aisle loses defecation signal.2. bowel lavage：The ecological balance for destroying normal flora in enteron aisle, there is dependence, cannot be thorough
Solve the problems, such as toxin expelling.3. slim tea：Contain cathartic and gastrointestinal tract stimulation component more, and is possible to cause liver, kidney diaseases.4. lymph
Massage：With limitation, controls in table do not control, be unable to essence toxin expelling.5. jejunitas toxin expelling：It is jejunitas to be not equal to toxin expelling, it can allow instead
Metabolic capabilities slow down, or even the atrophies such as the heart, kidney, gastrointestinal tract occur.6. food toxin expelling：Kelp, honey, mung bean etc. are cold
Cool food effect of ejecting poison is limited, is excessively used and causes enterogastric diseases.And common poison expelling capsule is mostly to add currently on the market
Defecation frequency reaches effect of ejecting poison, and the method for being equivalent to cathartic toxin expelling is commonly used, and cylinder electrolyte can be made uneven,
It is lost endotrophic, long enteron aisle loses defecation signal, negative unhealthy.
Summary of the invention
It is an object of the invention to overcome the deficiencies in the prior art, solve and are commonly used existing for existing poison expelling capsule,
Cylinder electrolyte can be made uneven, be lost endotrophic, the technical issues of long enteron aisle loses defecation signal, negative unhealthy.
The invention discloses following technical schemes；A kind of poison expelling capsule, including following raw material components：Organic calcium, stearic acid
Magnesium, Chinese medical extract, carrot, tea polyphenols, sweet potato, soybean, rice flour, maltodextrin and unsaturated fatty acid；Wherein each raw material
The weight content of component is：
Further, in order to make each raw material component play maximum effect, each raw material in poison expelling capsule prepared by the present invention
The weight content of component is preferably：
Further, in order to which the organic calcium component contained in poison expelling capsule is absorbed and utilized preferably by human body, organic calcium
For one of calcium citrate, calcium lactate or calcium gluconate.
Further, in order to make the important extract contained in poison expelling capsule that there is preferably synergistic effect, be conducive to people
Body toxin expelling, Chinese medical extract are fructus lycii, Radix Astragali, ginseng, aloe and ginkgo leaf in mass ratio 5:3:1:3:After 7 co-grindings, use
Dehydrated alcohol is made after solvent refluxing heating and evaporates the mixture after solvent.
Further, unsaturated fatty acid is one of oleic acid, linoleic acid or linolenic acid.
Wherein, the effect of each raw material component is played in poison expelling capsule prepared by the present invention is as follows：
Organic calcium is a kind of nutritional supplement, and calcium carbonate, calcium chloride, are not easily absorbed by the human body, for atrophic gastritis etc.
The patient of gastric anacidity, organic calcium are also beneficial to absorb.Organic calcium is that organic matter and body have good affinity, organic calcium
It is fast with the protease association reaction speed of body, and organic calcium will not stimulating intestine and stomach, constipation, excessive internal heat, calculus will not be caused.
Calcium citrate under the action of gastric juice (hydrochloric acid), resolves into a calcium ion and two negative one valence lemons into stomach
Lemon acid calcium root.In into enteron aisle in the form of calcium citrate anion, diffusion absorption；Enter in blood after absorption and plays middle transition
Buffer regulation balances the effect of free calcium, when calcium ion lacks in blood, is decomposed by kidney, slowly discharges calcium to blood
Ion；Sufficient negative valency calcium citrate in blood, passes through the internal circulation system deposit shape not soluble in water with double calcium citrates
Formula enriches skeletal calcium library；Citric acid is a kind of strong acid in human body, has strong complexing to calcium, forms calcium citrate and does not dissolve in
Water, it is soluble easily in water to form single calcium citrate, is not easily decomposed, so the citric acid of daily Metabolism Excretion, on the way of excretion
It is constantly excluded in vitro in conjunction with the calcium phase in the calcified material in blood vessel in diameter, to eliminate vascular sclerosis, eliminates urinary system
Calculus, it is suppressed that in vivo calcification, hardening, aging, fibrosis and calculus process.Calcium lactate has and promotes bone and tooth
The effects of calcification forms, maintains the normal excitability of nerve and muscle and reduces capillary permeability.Calcium gluconate can drop
Low capillary vasopermeability increases the compactness of capillary, reduces exudation, there is the effects of anti-inflammatory, detumescence and antiallergy, uses
In calcium deficiency, acute hypocalcemia and low blood calcium twitch etc..
Magnesium stearate, is mainly used as lubricant, antiplastering aid, glidant, the granulation of particularly suitable oils, extract medicament,
Manufactured particle has good mobility and compressibility, and glidant is used as in direct tablet compressing, is alternatively arranged as filter aid, clarification
The suspending agent of agent and drip infusion and liquid preparation, thickener.
Fructus lycii, polysaccharides are a kind of water-soluble polysaccharides, are most important active constituents in fructus lycii, there is promotion to be immunized,
The effects of anti-aging, antitumor, removing free radical, antifatigue, anti-radiation, liver protection, reproductive function protection and improvement；Glycine betaine is
Fructus lycii, leaf, one of main alkaloid in handle, are conducive to lipid-metabolism and anti-fatty liver；Wolfberry pigment is to be present in fructus lycii
All kinds of present-color materials in berry are the important physiologically active ingredients of fructus lycii seed, mainly include carrotene, lutein and other
Coloring matter has the effects that improve immune function of human body, prevention and inhibits tumour and prevention of arterial atherosis, wherein Hu trailing plants
Bu Su is with more important physiological functions such as anti-oxidant and synthesis precursors as vitamin A.
Radix Astragali has enhancing body's immunity, liver protection, diuresis, anti-aging, resisting stress, decompression and wide antibacterial to make
With.
Ginseng, contains a variety of saponins and polysaccharide component, and leachate can be expanded by skin slow-absorbing and without pessimal stimulation
Capillary of skin promotes skin blood circulation, increases skin-nourishing, adjust the water and oil balance of skin, prevents skin dehydration, hard
Change, corrugation, ginseng active substance inhibits the reducing property of melanin, keeps skin pure white smooth, can enhance skin elasticity, make cell
New life is obtained, is the superfine product improved looks.
Aloe, containing a large amount of amino acid, vitamin, polysaccharide compound, there is sterilization to disappear for various enzymes and minerals
Scorching, enhancing immune function, the effect for removing endotoxin and free radical can release constipation, prevention colitis, improve blood circulation,
Acne-removing, skin-nourishing promotes whole body health.The body fluid of Healthy People be it is alkaline, informal dress aloe products can make body fluid maintain alkalinity, keep
Health-physical fitness.It daily intakes enough aloe products and also helps absorption of the body reduction to grease in food, reach and preferably subtract
Weight and toxin expelling purpose.
Ginkgo leaf facilitates defaecation, diuresis, toxin expelling, removing toxic substances.
Carrot is crisp delicious, the full of nutrition homely vegetables of a germplasm, is known as the title of " glabrousleaf asiabell root ", carrot contains plant
Fibres, water imbibition is strong, and volume is easy expansion in enteron aisle, is " the full substance " in enteron aisle, can reinforce the wriggling of enteron aisle, from
And sharp diaphragm width intestines, facilitate catharsis and toxin expelling.
Tea polyphenols have very strong inoxidizability and physiological activity, are the scavengers of human free radical.
Sweet potato, nutritional ingredient necessary to the human bodies such as starch rich in, vitamin, cellulose, magnesium also rich in,
The mineral elements such as phosphorus, calcium and linoleic acid etc., these substances are able to maintain blood vessel elasticity, and to prevention and treatment, habitual constipation is largely effective, has
Help human detoxification.
Soybean, sweet in flavor, warm-natured, gas is flat, nontoxic, enters spleen, large intestine channel.With invigorating the spleen it is wide in, moisturize the water that disappears, it is clearing heat and detoxicating,
The effect of QI invigorating, cures mainly the thin thin, gestosis of infantile malnutrition due to digestive disturbances or intestinalparasites dysentery, abdominal distension, sore and toxic, traumatic hemorrhage etc.；Soybean can also antibacterial disappear
Inflammation is effective to pharyngitis, conjunctivitis, stomatitis, bacillary dysentery, enteritis.
The content of rice flour, iron is high, and good absorbing promotes hematopoiesis function, can enriching the blood and tonifying qi.
Maltodextrin, containing a large amount of polysaccharide, in addition also containing the microelement beneficial to human body such as calcium, iron and mine
Substance, and the metabolism of human normal can be promoted.
Unsaturated fatty acid is a kind of fatty acid for constituting body fat, the indispensable fatty acid of human body, but human body is not
Linoleic acid plus linolenic acid can be synthesized, it is necessary to supplement from diet, in diet when unsaturated fat subacidity, be also easy to produce lower epidemy
Disease：Low-density lipoprotein and low density cholesterol increase in blood, generate atherosclerosis, induce cardiovascular and cerebrovascular diseases；ω -3 is not
Saturated fatty acid is the important nutrition of brain and cranial nerve, and insufficiency of intake will affect memory and thinking ability, to infant
It will affect intellectual development, senile dementia will be generated to the elderly.
Oleic acid can reduce the bad cholesterol in blood total cholesterol, without reducing good cholesterol.
Linoleic acid can reduce blood cholesterol levels, prevention of arterial atherosis
Linolenic acid is a part of its function as growth, cell metabolism and muscular movement energy supply, is more conduct
Structural material and metabolic regulation substance play structure function and adjusting function.
The invention discloses a kind of preparation methods of poison expelling capsule, including following preparation step：
Step 1: the preparation of Chinese medical extract
First by the fructus lycii after drying, Radix Astragali, ginseng, aloe and ginkgo leaf in mass ratio 5:3:1:3:7 are weighed, then
Fructus lycii, Radix Astragali, ginseng, aloe and ginkgo leaf are crushed, and crushed material is added to and is contained with three mouthfuls of dehydrated alcohol
It is impregnated 3 hours in flask, then reheats return stirring and filter mixed liquor while hot after reflux 3~4 hours, retain filtrate,
Ethanol extract I is made；It collects filter cake and puts into it in three-necked flask again, continue to be made with dehydrated alcohol solvent to described
Filter cake is heated at reflux again, after filtering, is retained filtrate, is obtained ethanol extract II；The ethanol extract I and ethyl alcohol are extracted
Liquid II merges, and after being spin-dried for solvent with vacuum rotary evaporator in a heated state, obtains Chinese medical extract, spare；
Step 2: the preparation of diet material
Carrot, sweet potato and soybean are weighed, is put into Material disintegrator and is crushed after being cut into small pieces after cleaning, is sieved, then again
Crushed material is put into heating, drying in baking oven, up to diet material after natural cooling；
Step 3: introducing auxiliary material
Diet material obtained in Chinese medical extract obtained in step 1 and step 2 is mixed, then will be weighed
Organic calcium, magnesium stearate, tea polyphenols, rice flour, maltodextrin and unsaturated fatty acid be also stirred together, stirring in paste
Mixed material is put into sterilization treatment in the UV lamp after shape, it is spare；
Step 4: homogeneous, sieving, charging
By the mixed material after sterilizing in step 3 through it is high-pressure homogeneous, dry, again after pulverization process, 600~800 meshes of mistake
After obtain microsphere particle shape medicinal powder, then medicinal powder is fitted into capsulae vacuus, obtains poison expelling capsule；
Step 5: polishing, packaging
Poison expelling capsule obtained is put into after being polished in pill polishing machine, then dress, outer packing is wrapped inside.
Further, in order to extract the effective component of each raw material component in crushed material preferably, meanwhile, in order to prevent
Crushed material is added in step 1 and is contained with the three-necked flask of dehydrated alcohol and is heated to reflux and stirs by the excessively high change pharmacological property of heating temperature
It mixes, the temperature of heating is controlled at 80~85 DEG C；In order to make in step 1 last Chinese medical extract obtained purer, do not influence
The preparation of later period poison expelling capsule needs to remove the solvent being mixed in extract, and ethanol extract I and ethanol extract II are closed
And it is spin-dried for solvent with vacuum rotary evaporator in the case where 40~45 DEG C of heating water baths, vacuum degree are 0.5 atmospheric pressure, Chinese medicine is made
Extract.
Further, in order to keep diet material obtained fine and smooth uniformly, capsule particle is prepared conducive to the later period, will be claimed in step 2
Carrot, sweet potato and the soybean taken is put into Material disintegrator after being cut into small pieces after cleaning and is crushed, and crosses 100~120 mesh screens, dries
Temperature in case is controlled at 80 DEG C.
Further, in order to make capsule particle obtained convenient for oral, in step 4 in a poison expelling capsule medicinal powder weight
Amount is 0.6 ± 0.05g.
Poison expelling capsule produced by the present invention has the advantages that：Poison expelling capsule mostly uses Chinese medicine for formula, Chinese medicine
Compatibility is particular about " monarch " relationship, and the difference of medicinal flavor, the number of dosage and dosage form will directly affect in Chinese medicine compound prescription
To drug effect and the scope of application, poison expelling capsule produced by the present invention will not make cylinder electrolyte imbalance, endotrophic because of toxin expelling
It is lost, enteron aisle loses defecation signal, negative unhealthy etc..Poison expelling capsule produced by the present invention uses authentic chinese medicinal materials, QI invigorating
Promoting blood circulation, catharsis and toxin expelling, formula essence 5, row mends and takes into account, and accounts for toxin expelling effect without side-effects well, and produce preparation process
Simply, it is low to prepare cost of material price, convenient for promoting.
Specific embodiment
It elaborates below to the embodiment of the present invention, the present embodiment carries out under the premise of the technical scheme of the present invention
Implement, the detailed implementation method and specific operation process are given, but protection scope of the present invention is not limited to following implementation
Example.
Embodiment 1
Embodiment 1 discloses a kind of poison expelling capsule, including following raw material components：Organic calcium, magnesium stearate, traditional Chinese medicine extraction
Object, carrot, tea polyphenols, sweet potato, soybean, rice flour, maltodextrin and unsaturated fatty acid；
Wherein, the weight content of each raw material component is：
Wherein, organic calcium is one of calcium citrate, calcium lactate or calcium gluconate.
Wherein, Chinese medical extract is fructus lycii, Radix Astragali, ginseng, aloe and ginkgo leaf in mass ratio 5:3:1:3:7 co-grindings
Afterwards, made after solvent refluxing heating with dehydrated alcohol and evaporate the mixture after solvent.
Wherein, unsaturated fatty acid is one of oleic acid, linoleic acid or linolenic acid.
Present embodiment discloses a kind of preparation methods of poison expelling capsule, including following preparation step：
Step 1: the preparation of Chinese medical extract
First by the fructus lycii after drying, Radix Astragali, ginseng, aloe and ginkgo leaf in mass ratio 5:3:1:3:7 are weighed, then
Fructus lycii, Radix Astragali, ginseng, aloe and ginkgo leaf are crushed, and crushed material is added to and is contained with three mouthfuls of dehydrated alcohol
It is impregnated 3 hours in flask, then reheats return stirring and filter mixed liquor while hot after reflux 3 hours, retain filtrate, be made
Ethanol extract I；It collects filter cake and puts into it in three-necked flask again, continue to make solvent with dehydrated alcohol to filter cake again
It is heated at reflux, after filtering, retains filtrate, obtain ethanol extract II；Ethanol extract I and ethanol extract II are merged,
After being spin-dried for solvent with vacuum rotary evaporator under heated condition, Chinese medical extract is obtained, it is spare；
Step 2: the preparation of diet material
Carrot, sweet potato and soybean are weighed, is put into Material disintegrator and is crushed after being cut into small pieces after cleaning, is sieved, then again
Crushed material is put into heating, drying in baking oven, up to diet material after natural cooling；
Step 3: introducing auxiliary material
Diet material obtained in Chinese medical extract obtained in step 1 and step 2 is mixed, then will be weighed
Organic calcium, magnesium stearate, tea polyphenols, rice flour, maltodextrin and unsaturated fatty acid be also stirred together, stirring in paste
Mixed material is put into sterilization treatment in the UV lamp after shape, it is spare；
Step 4: homogeneous, sieving, charging
By the mixed material after sterilizing in step 3 through it is high-pressure homogeneous, dry, again after pulverization process, crossing after 600 meshes must
To microsphere particle shape medicinal powder, then medicinal powder is fitted into capsulae vacuus, obtains poison expelling capsule；
Step 5: polishing, packaging
Poison expelling capsule obtained is put into after being polished in pill polishing machine, then dress, outer packing is wrapped inside.
Wherein, crushed material is added in step 1 and is contained with the three-necked flask of dehydrated alcohol and is heated to reflux stirring, heated
Temperature control at 80 DEG C；And ethanol extract I and ethanol extract II are merged, are in 40 DEG C of heating water baths, vacuum degrees
It is spin-dried for solvent with vacuum rotary evaporator under 0.5 atmospheric pressure, Chinese medical extract is made.
Wherein, in step 2 by weighed carrot, sweet potato and soybean, be put into Material disintegrator after being cut into small pieces after cleaning into
Row crushes, and sieves with 100 mesh sieve net, and the temperature in baking oven is controlled at 80 DEG C.
Wherein, the weight of medicinal powder is 0.6 ± 0.05g in a poison expelling capsule in step 4.
Embodiment 2
Embodiment 2 discloses a kind of poison expelling capsule, including following raw material components：Organic calcium, magnesium stearate, traditional Chinese medicine extraction
Object, carrot, tea polyphenols, sweet potato, soybean, rice flour, maltodextrin and unsaturated fatty acid；Wherein, the weight of each raw material component
Content is：
Wherein, organic calcium is one of calcium citrate, calcium lactate or calcium gluconate.
Wherein, Chinese medical extract is fructus lycii, Radix Astragali, ginseng, aloe and ginkgo leaf in mass ratio 5:3:1:3:7 co-grindings
Afterwards, made after solvent refluxing heating with dehydrated alcohol and evaporate the mixture after solvent.
Wherein, unsaturated fatty acid is one of oleic acid, linoleic acid or linolenic acid.
Present embodiment discloses a kind of preparation methods of poison expelling capsule, including following preparation step：
Step 1: the preparation of Chinese medical extract
First by the fructus lycii after drying, Radix Astragali, ginseng, aloe and ginkgo leaf in mass ratio 5:3:1:3:7 are weighed, then
Fructus lycii, Radix Astragali, ginseng, aloe and ginkgo leaf are crushed, and crushed material is added to and is contained with three mouthfuls of dehydrated alcohol
It is impregnated 3 hours in flask, then reheats return stirring and filter mixed liquor while hot after reflux 4 hours, retain filtrate, be made
Ethanol extract I；It collects filter cake and puts into it in three-necked flask again, continue to make solvent with dehydrated alcohol to filter cake again
It is heated at reflux, after filtering, retains filtrate, obtain ethanol extract II；Ethanol extract I and ethanol extract II are merged,
After being spin-dried for solvent with vacuum rotary evaporator under heated condition, Chinese medical extract is obtained, it is spare；
Step 2: the preparation of diet material
Carrot, sweet potato and soybean are weighed, is put into Material disintegrator and is crushed after being cut into small pieces after cleaning, is sieved, then again
Crushed material is put into heating, drying in baking oven, up to diet material after natural cooling；
Step 3: introducing auxiliary material
Diet material obtained in Chinese medical extract obtained in step 1 and step 2 is mixed, then will be weighed
Organic calcium, magnesium stearate, tea polyphenols, rice flour, maltodextrin and unsaturated fatty acid be also stirred together, stirring in paste
Mixed material is put into sterilization treatment in the UV lamp after shape, it is spare；
Step 4: homogeneous, sieving, charging
By the mixed material after sterilizing in step 3 through it is high-pressure homogeneous, dry, again after pulverization process, crossing after 800 meshes must
To microsphere particle shape medicinal powder, then medicinal powder is fitted into capsulae vacuus, obtains poison expelling capsule；
Step 5: polishing, packaging
Poison expelling capsule obtained is put into after being polished in pill polishing machine, then dress, outer packing is wrapped inside.
Wherein, crushed material is added in step 1 and is contained with the three-necked flask of dehydrated alcohol and is heated to reflux stirring, heated
Temperature control at 85 DEG C；And ethanol extract I and ethanol extract II are merged, are in 45 DEG C of heating water baths, vacuum degrees
It is spin-dried for solvent with vacuum rotary evaporator under 0.5 atmospheric pressure, Chinese medical extract is made.
Wherein, in step 2 by weighed carrot, sweet potato and soybean, be put into Material disintegrator after being cut into small pieces after cleaning into
Row crushes, and crosses 120 mesh screens, and the temperature in baking oven is controlled at 80 DEG C.
Wherein, the weight of medicinal powder is 0.6 ± 0.05g in a poison expelling capsule in step 4.
Embodiment 3
Embodiment 3 discloses a kind of poison expelling capsule, including following raw material components：Organic calcium, magnesium stearate, traditional Chinese medicine extraction
Object, carrot, tea polyphenols, sweet potato, soybean, rice flour, maltodextrin and unsaturated fatty acid；Wherein, the weight of each raw material component
Content is：
Wherein, organic calcium is one of calcium citrate, calcium lactate or calcium gluconate.
Wherein, Chinese medical extract is fructus lycii, Radix Astragali, ginseng, aloe and ginkgo leaf in mass ratio 5:3:1:3:7 co-grindings
Afterwards, made after solvent refluxing heating with dehydrated alcohol and evaporate the mixture after solvent.
Wherein, unsaturated fatty acid is one of oleic acid, linoleic acid or linolenic acid.
Present embodiment discloses a kind of preparation methods of poison expelling capsule, including following preparation step：
Step 1: the preparation of Chinese medical extract
First by the fructus lycii after drying, Radix Astragali, ginseng, aloe and ginkgo leaf in mass ratio 5:3:1:3:7 are weighed, then
Fructus lycii, Radix Astragali, ginseng, aloe and ginkgo leaf are crushed, and crushed material is added to and is contained with three mouthfuls of dehydrated alcohol
It is impregnated 3 hours in flask, then reheats return stirring and filter mixed liquor while hot after reflux 3.5 hours, retain filtrate, system
Obtain ethanol extract I；It collects filter cake and puts into it in three-necked flask again, continue to make solvent with dehydrated alcohol to filter cake again
It is secondary to be heated at reflux, after filtering, retains filtrate, obtain ethanol extract II；Ethanol extract I and ethanol extract II are merged,
After being spin-dried for solvent with vacuum rotary evaporator in a heated state, Chinese medical extract is obtained, it is spare；
Step 2: the preparation of diet material
Carrot, sweet potato and soybean are weighed, is put into Material disintegrator and is crushed after being cut into small pieces after cleaning, is sieved, then again
Crushed material is put into heating, drying in baking oven, up to diet material after natural cooling；
Step 3: introducing auxiliary material
Diet material obtained in Chinese medical extract obtained in step 1 and step 2 is mixed, then will be weighed
Organic calcium, magnesium stearate, tea polyphenols, rice flour, maltodextrin and unsaturated fatty acid be also stirred together, stirring in paste
Mixed material is put into sterilization treatment in the UV lamp after shape, it is spare；
Step 4: homogeneous, sieving, charging
By the mixed material after sterilizing in step 3 through it is high-pressure homogeneous, dry, again after pulverization process, crossing after 700 meshes must
To microsphere particle shape medicinal powder, then medicinal powder is fitted into capsulae vacuus, obtains poison expelling capsule；
Step 5: polishing, packaging
Poison expelling capsule obtained is put into after being polished in pill polishing machine, then dress, outer packing is wrapped inside.
Wherein, crushed material is added in step 1 and is contained with the three-necked flask of dehydrated alcohol and is heated to reflux stirring, heated
Temperature control at 83 DEG C；And ethanol extract I and ethanol extract II are merged, are in 43 DEG C of heating water baths, vacuum degrees
It is spin-dried for solvent with vacuum rotary evaporator under 0.5 atmospheric pressure, Chinese medical extract is made.
Wherein, in step 2 by weighed carrot, sweet potato and soybean, be put into Material disintegrator after being cut into small pieces after cleaning into
Row crushes, and crosses 110 mesh screens, and the temperature in baking oven is controlled at 80 DEG C.
Wherein, the weight of medicinal powder is 0.6 ± 0.05g in a poison expelling capsule in step 4.
Embodiment 4
Embodiment 4 discloses a kind of poison expelling capsule, including following raw material components：Organic calcium, magnesium stearate, traditional Chinese medicine extraction
Object, carrot, tea polyphenols, sweet potato, soybean, rice flour, maltodextrin and unsaturated fatty acid；Wherein, the weight of each raw material component
Content is：
Wherein, organic calcium is one of calcium citrate, calcium lactate or calcium gluconate.
Wherein, Chinese medical extract is fructus lycii, Radix Astragali, ginseng, aloe and ginkgo leaf in mass ratio 5:3:1:3:7 co-grindings
Afterwards, made after solvent refluxing heating with dehydrated alcohol and evaporate the mixture after solvent.
Wherein, unsaturated fatty acid is one of oleic acid, linoleic acid or linolenic acid.
Present embodiment discloses a kind of preparation methods of poison expelling capsule, including following preparation step：
Step 1: the preparation of Chinese medical extract
First by the fructus lycii after drying, Radix Astragali, ginseng, aloe and ginkgo leaf in mass ratio 5:3:1:3:7 are weighed, then
Fructus lycii, Radix Astragali, ginseng, aloe and ginkgo leaf are crushed, and crushed material is added to and is contained with three mouthfuls of dehydrated alcohol
It is impregnated 3 hours in flask, then reheats return stirring and filter mixed liquor while hot after reflux 4 hours, retain filtrate, be made
Ethanol extract I；It collects filter cake and puts into it in three-necked flask again, continue to make solvent with dehydrated alcohol to filter cake again
It is heated at reflux, after filtering, retains filtrate, obtain ethanol extract II；Ethanol extract I and ethanol extract II are merged,
After being spin-dried for solvent with vacuum rotary evaporator under heated condition, Chinese medical extract is obtained, it is spare；
Step 2: the preparation of diet material
Carrot, sweet potato and soybean are weighed, is put into Material disintegrator and is crushed after being cut into small pieces after cleaning, is sieved, then again
Crushed material is put into heating, drying in baking oven, up to diet material after natural cooling；
Step 3: introducing auxiliary material
Diet material obtained in Chinese medical extract obtained in step 1 and step 2 is mixed, then will be weighed
Organic calcium, magnesium stearate, tea polyphenols, rice flour, maltodextrin and unsaturated fatty acid be also stirred together, stirring in paste
Mixed material is put into sterilization treatment in the UV lamp after shape, it is spare；
Step 4: homogeneous, sieving, charging
By the mixed material after sterilizing in step 3 through it is high-pressure homogeneous, dry, again after pulverization process, crossing after 600 meshes must
To microsphere particle shape medicinal powder, then medicinal powder is fitted into capsulae vacuus, obtains poison expelling capsule；
Step 5: polishing, packaging
Poison expelling capsule obtained is put into after being polished in pill polishing machine, then dress, outer packing is wrapped inside.
Wherein, crushed material is added in step 1 and is contained with the three-necked flask of dehydrated alcohol and is heated to reflux stirring, heated
Temperature control at 80 DEG C；And ethanol extract I and ethanol extract II are merged, are in 40 DEG C of heating water baths, vacuum degrees
It is spin-dried for solvent with vacuum rotary evaporator under 0.5 atmospheric pressure, Chinese medical extract is made.
Wherein, in step 2 by weighed carrot, sweet potato and soybean, be put into Material disintegrator after being cut into small pieces after cleaning into
Row crushes, and sieves with 100 mesh sieve net, and the temperature in baking oven is controlled at 80 DEG C.
Wherein, the weight of medicinal powder is 0.6 ± 0.05g in a poison expelling capsule in step 4.
One, the clinical test of toxin expelling patient is needed for facial skin.
1, subjects：250 need toxin expelling patient, male 165, female 85.
2, treatment method
Toxin expelling patient is needed to be divided into treatment group's (totally four groups of Examples 1 to 4) and control by 250 using the principle of parallel control
Group (totally one group), every group of 50 patients.
Through statistical analysis, each group Gender, age, the course of disease, the there was no significant difference (P such as grading>0.05), have
There is comparativity.
Treatment group：Poison expelling capsule produced by the present invention is taken orally, each taking 1,2 times a day, once in the morning and once at night.
Control group：Take orally green forest board soft capsule with aloe, application method and the same treatment group of the frequency.
3, judgment criteria：
(1) effective：The symptoms such as cheek is greasy, small pox, pore is coarse, the colour of skin is obscure completely disappear, and facial skin restores bullet
Property water profit；
(2) effectively：The symptoms such as cheek is greasy, small pox, pore is coarse, the colour of skin is obscure disappear substantially, take an evident turn for the better, but still
There is the above remaining trace of each symptom；
(3) invalid：The symptoms such as cheek is greasy, small pox, pore is coarse, the colour of skin is obscure are not improved.
Data after comparative test are recorded, the affected part number of days used that fully recovers is fewer, rehabilitation people in same time
The more more then drug effects of number are better.
4, result on trial：It is shown in Table 1.
Table 1
After the data that are recorded by table 1 are it is found that the poison expelling capsule that the present invention is prepared takes, in three weeks, facial skin
The symptoms such as the greasy of toxin expelling patient, small pox, pore are coarse, the colour of skin is obscure are needed all to disappear, facial skin restores elastic water profit, and
Capsule slow effect in control group, and need oral healing time longer, and after using one month, patient is generally reflected because of row
Bowel frequency number is excessive, so that cylinder electrolyte is uneven, endotrophic is lost, enteron aisle loses the appearance of the ill symptoms such as defecation signal.
Two, typical case：
Certain is congratulated, female, 22 years old, student, Oily, skin pore were coarse, the colour of skin is obscure, since sebum secretion is more prosperous
It contains, face shows glossy gloss, and flesh texture is thick, and pore is big and obvious, take poison expelling capsule produced by the present invention after a week,
Skin greasing state is obviously improved, and is being continued to take later after two weeks, and skin restores water profit gloss, pore convergence, and in the later period
It is not recurred in 1 year of observation.
Poplar, female 25 years old, do in an advertising company and plan, and usually operating pressure is bigger, often have a sleepless night, script face
On only several acnes, but because work it is busy do not manage it and have been found that acne on the face is more and more, also once attempted beauty in the past before
To hold institute and squeeze acne toxin expelling, but can recur again after a period of time, takes poison expelling capsule produced by the present invention after two weeks, small pox disappears,
There are many obvious bright and clean of skin, continuing to take later after two weeks, which does not occur again, and in 1 year of later observations
It does not recur.
What certain, male, 22 years old, senior, because face repeatedly cure in locality by multiple papulo-vesicle 3 years, on March 23rd, 2018
Institute is medical, through looking into：Forehead, cheeks, mouth Zhou Duofa pustular eruption, are dispersed in the scar left after red papules and tumour ulceration therebetween
Trace occasionally has and gently itches, and the tip of the tongue is partially red, yellow tongue fur.Patient's readme over nearly 3 years above-mentioned symptom occur repeatedly, multi-treatment, curative effect is little,
It is very worries, synthesis is diagnosed as：Acne takes poison expelling capsule produced by the present invention after three weeks, and face acnes are clearly better, skin
Restore gloss, continuing to take later after a week, cures completely, and do not recurred in 1 year of later observations.
Zou, male 26 years old, have suffered from as long as acne has 6 years, when incipient, taking notice of, have felt more
With advancing age, can turn better, however it is but more longer more, it has been covered with pimple on the face, the sign not subsided at all is even
Your itch is hard to bear.Over time, little Zou is small pox worry on the face all day long, and has started the road of hardships sought medical advice, and is just started
It only takes medicine, at first effect or good, however once being discontinued and be reoccurred again.He also receives various control later
It treats, as long as someone recommends which kind for the treatment of method or product for resolving poxes good, he attempts one by one, but whelk still exists repeatedly
Long, there is no cure.Take poison expelling capsule produced by the present invention after three weeks, face acnes are clearly better, and skin restores gloss,
Continue to take after two weeks later, cure completely, and do not recurred in 1 year of later observations.
Poison expelling capsule prepared by the present invention, the raw material components contained：Calcium citrate, can eliminate vascular sclerosis, and elimination is secreted
Urinary system calculus, it is suppressed that in vivo calcification, hardening, aging, fibrosis and calculus process；Calcium lactate, have promote bone and
The effects of calcification of tooth forms, maintains the normal excitability of nerve and muscle and reduces capillary permeability；Gluconic acid
Calcium can reduce capillary permeability, increase the compactness of capillary, reduce exudation, there is anti-inflammatory, detumescence and antiallergy etc.
Effect；Fructus lycii has and immune, anti-aging, antitumor, removing free radical, antifatigue, anti-radiation, liver protection, reproductive function is promoted to protect
The effects of shield and improvement；Glycine betaine is conducive to lipid-metabolism and anti-fatty liver；Wolfberry pigment, have improve immune function of human body,
The effects of prevention and inhibition tumour and prevention of arterial atherosis, wherein carrotene is with more anti-oxidant and as vitamin A
Synthesize the important physiological functions such as precursor；Radix Astragali has enhancing body's immunity, liver protection, diuresis, anti-aging, resisting stress, decompression
With wide antibacterial action；Ginseng can expand capillary of skin, promote skin blood circulation, increase skin-nourishing, adjust
The water and oil balance of skin, prevents skin dehydration, hardening, corrugation, and ginseng active substance inhibits the reducing property of melanin, makes skin
It is pure white smooth, skin elasticity can be enhanced, obtain cell newborn, be the superfine product improved looks；Aloe has bactericidal antiphlogistic, increases
Strong immune function, the effect for removing endotoxin and free radical can release constipation, prevention colitis, improve blood circulation, and anti-acne is supported
Face promotes whole body health；Ginkgo leaf facilitates defaecation, diuresis, toxin expelling, removing toxic substances；Carrot can reinforce the wriggling of enteron aisle, thus
Sharp diaphragm width intestines facilitate catharsis and toxin expelling；Tea polyphenols have very strong inoxidizability and physiological activity, are the clear of human free radical
Except agent；Sweet potato is able to maintain blood vessel elasticity, and to prevention and treatment, habitual constipation is largely effective, facilitates human detoxification；Soybean has strong
During spleen is wide, the effect of moisturizing the water that disappears, clearing heat and detoxicating, QI invigorating；Soybean can also antibacterial anti-inflammatory；Rice flour promotes hematopoiesis function, can enrich blood
QI invigorating；Maltodextrin can promote the metabolism of human normal；Oleic acid can reduce harmful gallbladder in blood total cholesterol
Sterol, without reducing good cholesterol；Linoleic acid can reduce blood cholesterol levels, prevention of arterial atherosis；Linolenic acid, as
Structural material and metabolic regulation substance play structure function and adjusting function.
Due to capsule prepared by the present invention mostly use authentic chinese medicinal materials for formula, after being taken it can qi and activate blood circulation, lead to
Just toxin expelling, row mend and take into account, and therefore, poison expelling capsule of the invention is well-established by neighbouring group extensively at present.
Claims (9)
1. a kind of poison expelling capsule, which is characterized in that including following raw material components：Organic calcium, magnesium stearate, Chinese medical extract, Hu
Radish, tea polyphenols, sweet potato, soybean, rice flour, maltodextrin and unsaturated fatty acid；The wherein weight content of the raw material components
For：
2. poison expelling capsule as described in claim 1, which is characterized in that the weight content of the raw material components is：
3. poison expelling capsule as described in claim 1, which is characterized in that the organic calcium is calcium citrate, calcium lactate or grape
One of Calciofon.
4. poison expelling capsule as described in claim 1, which is characterized in that the Chinese medical extract is fructus lycii, Radix Astragali, ginseng, reed
Luxuriant growth and ginkgo leaf in mass ratio 5:3:1:3:After 7 co-grindings, is made after solvent refluxing heating with dehydrated alcohol and evaporate solvent
Mixture afterwards.
5. poison expelling capsule as described in claim 1, which is characterized in that the unsaturated fatty acid is oleic acid, linoleic acid or Asia
One of numb acid.
6. a kind of preparation method of the poison expelling capsule as described in claim 1-5 is any, which is characterized in that walked including following preparation
Suddenly：
Step 1: the preparation of Chinese medical extract
First by the fructus lycii after drying, Radix Astragali, ginseng, aloe and ginkgo leaf in mass ratio 5:3:1:3:7 are weighed, then by Chinese holly
Qi, Radix Astragali, ginseng, aloe and ginkgo leaf are crushed, and crushed material is added to the three-necked flask for being contained with dehydrated alcohol
It is interior to impregnate 3 hours, it then reheats return stirring and filters mixed liquor while hot after reflux 3~4 hours, retain filtrate, be made
Ethanol extract I；It collects filter cake and puts into it in three-necked flask again, continue to be made with dehydrated alcohol solvent to the filter cake
It is heated at reflux again, after filtering, retains filtrate, obtain ethanol extract II；By the ethanol extract I and ethanol extract II
Merge, after being spin-dried for solvent with vacuum rotary evaporator in a heated state, obtains Chinese medical extract, it is spare；
Step 2: the preparation of diet material
Carrot, sweet potato and soybean are weighed, is put into Material disintegrator and is crushed after being cut into small pieces after cleaning, is sieved, then again by powder
Particle is put into heating, drying in baking oven, up to diet material after natural cooling；
Step 3: introducing auxiliary material
Diet material obtained in Chinese medical extract obtained in step 1 and step 2 is mixed, is then had load weighted
Machine calcium, magnesium stearate, tea polyphenols, rice flour, maltodextrin and unsaturated fatty acid are also stirred together, after stirring in the pasty state
Mixed material is put into sterilization treatment in the UV lamp, it is spare；
Step 4: homogeneous, sieving, charging
By the mixed material after sterilizing in step 3 through it is high-pressure homogeneous, dry, again after pulverization process, crossing after 600~800 meshes must
To microsphere particle shape medicinal powder, then medicinal powder is fitted into capsulae vacuus, obtains poison expelling capsule；
Step 5: polishing, packaging
Poison expelling capsule obtained is put into after being polished in pill polishing machine, then dress, outer packing is wrapped inside.
7. the preparation method of poison expelling capsule as claimed in claim 6, which is characterized in that be added to the crushed material in step 1
The three-necked flask for being contained with dehydrated alcohol is heated to reflux stirring, and the temperature of heating is controlled at 80~85 DEG C；And ethyl alcohol is extracted
Liquid I and ethanol extract II merge, and use rotary evaporation in vacuo in the case where 40~45 DEG C of heating water baths, vacuum degree are 0.5 atmospheric pressure
Instrument is spin-dried for solvent, and Chinese medical extract is made.
8. the preparation method of poison expelling capsule as claimed in claim 6, which is characterized in that by weighed carrot, sweet potato in step 2
And soybean, it is put into Material disintegrator and is crushed after being cut into small pieces after cleaning, cross 100~120 mesh screens, the temperature in the baking oven
Control is at 80 DEG C.
9. the preparation method of poison expelling capsule as claimed in claim 6, which is characterized in that in step 4 in a poison expelling capsule
The weight of medicinal powder is 0.6 ± 0.05g.
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| CN108355042A (en) * | 2018-05-28 | 2018-08-03 | 陈雨薇 | A kind of anti-inflammatory analgetic ointment and preparation method thereof |
| CN108355125A (en) * | 2018-05-28 | 2018-08-03 | 陈雨薇 | Anti- chap ointment of one kind and preparation method thereof |
| CN109865003A (en) * | 2019-04-19 | 2019-06-11 | 梁晓喻 | The ointment and preparation method thereof for treating cutaneous pruritus caused by acne and eczema |
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