CN106620367A - Traditional Chinese medicine sustained-release capsule for treating cystolith and preparation method thereof - Google Patents
Traditional Chinese medicine sustained-release capsule for treating cystolith and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine sustained-release capsule for treating cystolith and a preparation method thereof and belongs to the technical field of medicines. The traditional Chinese medicine sustained-release capsule comprises the following traditional Chinese medicine raw material effective components: endothelium corneum gigeriae galli, unprocessed radix astragali, unprocessed white peony root, rhizoma anemarrhenae saltpeter, mirabilite, herba desmodii styracifolii, stigma maydis, folium pyrrosiae, abrus herb, poria, plantain herb, lygodium japonicum herb, rhizoma imperatae, herba incarvller, small centipeda herb, rhizoma corydalis, talcum powder, microcrystalline methylcellulose, ethyecellulose, glyceride and polyethylene glycol. The preparation method of the traditional Chinese medicine sustained-release capsule comprises the following steps: preparing raw materials, extracting traditional Chinese medicine raw material effective components, preparing a traditional Chinese medicine raw material effective component containing pill core, preparing a traditional Chinese medicine raw material effective component sustained-release micro pill, and filling a capsule. A method of eliminating lithiasis, balancing blood pH and improving lithiasis physique is used for starting the treatment of cystolith. The selected traditional Chinese medicine materials are reasonable in compatibility; the traditional Chinese medicine sustained-release capsule is prepared by using modern advanced sustained-release medicine preparation technique; the traditional Chinese medicine sustained-release capsule is high in action speed and high in stability, and is extremely suitable for patients with cystolith.
Description
Technical field
The invention belongs to pharmaceutical technology field, is concretely a kind of traditional Chinese medicine slow-releasing capsule for treating vesical calculus and preparation
Method.
Background technology
Calculus is made up of inorganic salts or organic matter.Normally there is a core in calculus, by the epithelial cell, bacterial mass that come off
Block, parasitic ovum or polypide, excrement block or foreign matter composition, inorganic salts or organic matter are deposited layer by layer again on core.Due to device of being involved
The difference of official, the composition, shape, quality contained by lithogenous mechanism, the impact to body etc. are differed.Calculus is as U.S.
Beautiful stone, circle, it is oval, as beautiful Yuhuatai colorful pebble, also something like seabed coral, star such as in the sky, noble deer horn.
Also many bizarre-shaped calculus, big picture duck's egg is little such as the grain of rice, or even as silt, it is dazzling.These
The beautiful artificial stone of appearance, giving people impression that body brings can just less " beautiful ".Lithiasis is a kind of common frequently-occurring disease,
It includes cholecystolithiasis, stones in intrahepatic bile duct, choledocholithiasis, lithangiuria, and lithangiuria includes double kidney stone, ureter, bladders
Calculus, urethral calculus, other position calculus.In addition to foregoing, still there are indivedual rare calculus.
Medical research finds that lithiasis is to cause metabolism sanitary fill because blood of human body acid-base value is unbalance,
That is Iithiasic old complaint is in blood.Traditional treatment, including the treatment of operation, external stone crushing, laser lithotripsy etc., be all
Calculus is only removed, blood pH is not balanced, shortterm effect can only be played, it is impossible to thoroughly cure lithiasis.Radical cure lithiasis must
Must work along both lines：First, calculus is eliminated；2nd, blood pH is balanced.
Mostly patient thinks that calculus is because improper diet formation at ordinary times, in fact according to the research of expert, calculus
Arch-criminal be that patient itself has defined in vivo " calculus physique ", and diet merely causes calculus
One side factor and with so wanting thoroughly to treat calculus, physique that is main or improving patient.
The content of the invention
In order to thoroughly treat calculus, the invention provides a kind of traditional Chinese medicine slow-releasing capsule for treating vesical calculus and preparation side
Method, the spansule is using clearing heat and detoxicating, fossil exclusion, the treatment method for improving patient's physique.
The present invention seeks to realized by technical scheme below：
A kind of traditional Chinese medicine slow-releasing capsule for treating vesical calculus, the Chinese medicine material medicine of the traditional Chinese medicine slow-releasing capsule includes：Chicken
Interior golden 50 ~ 55 parts, raw 20 ~ 25 parts of the Radix Astragali, raw 20 ~ 25 parts of Hangzhoupro Chinese herbaceous peony, 25 ~ 30 parts of the wind-weed, 1 ~ 3 part of nitre, 1 ~ 3 part of mirabilite, wide gold
40 ~ 45 parts of money grass, 40 ~ 45 parts of corn stigma, 30 ~ 35 parts of pyrrosia lingua, 35 ~ 40 parts of Canton love-pea vine, 45 ~ 50 parts of Poria cocos, Asiatic plantain 35 ~ 40
Part, 35 ~ 40 parts of Herba lygodii, 20 ~ 25 parts of cogongrass rhizome, 25 ~ 30 parts of calculus grass, 35 ~ 40 parts of Centipeda minima, 30 ~ 35 parts of corydalis tuber,
15 ~ 20 parts of talcum powder, 25 ~ 30 parts of crystallite methylcellulose, 20 ~ 25 parts of ethyl cellulose, 3 ~ 5 parts of glyceride, polyethylene glycol 2 ~ 4
Part.
Further the object of the invention can be being realized by technical scheme below：
A kind of traditional Chinese medicine slow-releasing capsule for treating vesical calculus, the Chinese medicine material medicine of the traditional Chinese medicine slow-releasing capsule includes：Chicken
Interior golden 50 parts, raw 20 parts of the Radix Astragali, raw 20 parts of Hangzhoupro Chinese herbaceous peony, 25 parts of the wind-weed, 1 part of nitre, 1 part of mirabilite, 40 parts of Desmodium styracifolium, corn stigma 40
Part, 30 parts of pyrrosia lingua, 35 parts of Canton love-pea vine, 45 parts of Poria cocos, 35 parts of Asiatic plantain, 35 parts of Herba lygodii, 20 parts of cogongrass rhizome, calculus grass 25
Part, 35 parts of Centipeda minima, 30 parts of corydalis tuber, 15 parts of talcum powder, 25 parts of crystallite methylcellulose, 20 parts of ethyl cellulose, glyceride 3
Part, 2 parts of polyethylene glycol.
A kind of traditional Chinese medicine slow-releasing capsule for treating vesical calculus, the Chinese medicine material cartridge bag of the traditional Chinese medicine slow-releasing capsule
Include：55 parts of the membrane of a chicken's gizzard, raw 25 parts of the Radix Astragali, raw 25 parts of Hangzhoupro Chinese herbaceous peony, 30 parts of the wind-weed, 3 parts of nitre, 3 parts of mirabilite, 45 parts of Desmodium styracifolium, jade
45 parts of rice palpus, 35 parts of pyrrosia lingua, 40 parts of Canton love-pea vine, 50 parts of Poria cocos, 40 parts of Asiatic plantain, 40 parts of Herba lygodii, 25 parts of cogongrass rhizome, calculus
It is 30 parts of grass, 40 parts of Centipeda minima, 35 parts of corydalis tuber, 20 parts of talcum powder, 30 parts of crystallite methylcellulose, 25 parts of ethyl cellulose, sweet
5 parts of grease, 4 parts of polyethylene glycol.
A kind of traditional Chinese medicine slow-releasing capsule for treating vesical calculus, the Chinese medicine material cartridge bag of the traditional Chinese medicine slow-releasing capsule
Include：52 parts of the membrane of a chicken's gizzard, raw 23 parts of the Radix Astragali, raw 21 parts of Hangzhoupro Chinese herbaceous peony, 26 parts of the wind-weed, 1.2 parts of nitre, 2 parts of mirabilite, 44 parts of Desmodium styracifolium,
43 parts of corn stigma, 32 parts of pyrrosia lingua, 37 parts of Canton love-pea vine, 46 parts of Poria cocos, 38 parts of Asiatic plantain, 37 parts of Herba lygodii, 24 parts of cogongrass rhizome, knot
Stone grass 29 parts, 36 parts of Centipeda minima, 33 parts of corydalis tuber, 18 parts of talcum powder, 27 parts of crystallite methylcellulose, 22 parts of ethyl cellulose,
4 parts of glyceride, 3 parts of polyethylene glycol.
Present invention also offers a kind of preparation method of the traditional Chinese medicine slow-releasing capsule for treating vesical calculus, comprises the steps：
1）Get the raw materials ready, get the raw materials ready according to the component and weight fraction of a kind of traditional Chinese medicine slow-releasing capsule for treating vesical calculus, the membrane of a chicken's gizzard is crushed
400 mesh sieves are crossed, nitre, mirabilite crushed respectively 100 mesh sieves, and microcrystalline cellulose, talcum powder crushed respectively 80 mesh sieves；
2）The extraction of Chinese medicine material pharmaceutically active ingredient, by water of the parts by weight for 10 times of Chinese medicine material medicine Chinese medicine extracting tank is added
In, open stirring, by Chinese medicine material medicine give birth to the Radix Astragali, raw Hangzhoupro Chinese herbaceous peony, the wind-weed, Desmodium styracifolium, corn stigma, pyrrosia lingua, Canton love-pea vine, Poria cocos,
Asiatic plantain, Herba lygodii, cogongrass rhizome, calculus grass, Centipeda minima, corydalis tuber are added in Chinese medicine extracting tank, by Chinese medicine extracting tank
Temperature of charge be heated to 95 ~ 100 DEG C, constant temperature 30min, 80 mesh are filtered, and take filtrate, filter residue, are Chinese medicine material by parts by weight
The water that 10 times of medicine is added in Chinese medicine extracting tank, opens stirring, and filter residue is added in Chinese medicine extracting tank, by the thing in Chinese medicine extracting tank
Material temperature degree is heated to 95 ~ 100 DEG C, and constant temperature 30min, 80 mesh are filtered, and take filtrate；Merge 2 gained filtrates, be concentrated in vacuo to original
/ 8th of filtrate volume obtain Chinese medical extract；
3）The preparation of Chinese medicine material pharmaceutically active ingredient pellet core, the membrane of a chicken's gizzard, nitre, mirabilite, Chinese medical extract, crystallite is fine
Dimension element, talcum powder are well mixed to obtain mixture a, add the alcohol that mass concentration is 95 ~ 100% to stir in mixture a
Mixture b, alcohol consumption is 1/3rd of mixture a gross weight numbers, and mixture b is granulated by centrifugal granulator, from
Scheming rotating speed is 200r/min, baking temperature is 40 ~ 45 DEG C；
4）The preparation of Chinese medicine material pharmaceutically active ingredient sustained release pellet, it is using stable fluid bed bottom spray art for coating, ethyl is fine
Dimension element, glyceride, polyethylene glycol mass concentration dissolve for 70% ~ 80% alcohol, obtain Coating Solution, and the consumption of alcohol is ethyl
Cellulose, glyceride, 10 times of polyethylene glycol weight, Coating Solution is sprayed onto into step 3）In gained pellet core, sustained release is made
Micropill；
5）Dress capsule, by step 4）Gained sustained release pellet fills capsule by tire bagger, and specification is per 0.5 ~ 1.0g of weight.
Further, preparation method of the invention can be being realized by technical scheme below：
Vacuum concentration process condition is in the extraction step of the Chinese medicine material pharmaceutically active ingredient：Pressure be -0.07 ~ -
0.08Mpa, temperature are 45 ~ 50 DEG C.
The step 4）The coating process parameters of sustained release pellet are：EAT is 50 ~ 55 DEG C, and temperature of charge is 35 ~ 40
DEG C, feed flow rotating speed is 60rpm, and blower fan frequency is 25Hz, and atomizing pressure is 0.12Mpa.
The present invention is screened through a large amount of screening tests to Chinese medicine bulk drug, using clearing heat and detoxicating, fossil exclusion, is improved
The treatment method of patient's physique.Selected all Chinese medicine material medicines have following effect：
The membrane of a chicken's gizzard：It is cold in nature, sweet, returns spleen, stomach, small intestine, bladder warp；Appropriate digested bad, sallow complexion, Na Gu, children are not thought
The condition subjects such as infantile malnutrition due to digestive disturbances or intestinalparasites, body are become thin, the big abdominal distension of abdomen, weakness of the spleen and the stomach, dyspepsia turgor, intestinal tuberculosis, bone tuberculosis eat.
The membrane of a chicken's gizzard itself after medication secretory volume of gastric juice can increase and stomach fortune containing only micro pepsin and amylase
It is dynamic to strengthen, it is believed that possibly the membrane of a chicken's gizzard digest and assimilate after caused by neuromuscular by the excited coat of the stomach of humoral factor.Also have and think
It is that gastric hormone promotes stomachial secretion function.As a result the food digesting action for pointing out the membrane of a chicken's gizzard be not local action of the medicine in stomach or
What direct stimulating intestine and stomach motion caused, it may be possible to which medicine is played to help indirectly and disappeared after digesting into blood stimulation stomach glandular secretion increase
Change is acted on.
The raw Radix Astragali：It is sweet, tepor, with invigorating qi for strengthening superficies, torr sore myogenic, effect of Li Shui, cure mainly deficient qi and blood, spontaneous perspiration,
The diseases such as rush down prolapse of the anus for a long time, the prolapse of uterus, ephritis edema, albuminuria, diabetes, chronic ulcer.
Raw Hangzhoupro Chinese herbaceous peony：The i.e. raw root of herbaceous peony, its cold nature, bitter, acid.Function is smooth liver and relieve pain, nourishing blood for regulating menstruation, astringing YIN to stop sweating.It is main
It is used for dizziness of having a headache, hypochondriac pain, stomachache, four limbs contraction pain, blood deficiency chlorosis, irregular menstruation, spontaneous perspiration, night sweat.
The wind-weed：It is cold in nature, it is bitter, sweet；Return lung, stomach, kidney channel.Effect：Clearing heat-fire, fluid dryness.For fever caused by exogenous pathogenic factors,
Hyperpyrexia polydipsia, lung-heat type cough, osteopyrexia and fever, Heat Diabetes, dry constipation of intestines.
Nitre：Cold in nature, bitter, nontoxic, water white transparency prism crystal or powder.Main component potassium nitrate.
Mirabilite：Cold in nature, taste is salty, hardship；Return stomach；Lung channel；The spleen channel；Kidney channel；Small intestinl channel；Tri-jiao channel；Large intestine channel.Function and master
Control：Purgating heat and bowels, moistening for dryness and softening hard mass, detumescence of relieving inflammation or internal heat.For real heat constipation, dry feces, stagnate stomachache, and acute appendicitis swells and ache；Breast is controlled outward
Carbuncle, hemorrhoid gall.
Desmodium styracifolium：Desmodium styracifolium has functions that invigorating gallbladder and removing gall-stone and diuresis and stone expeling mouth.Clearing heat and removing internal wetness, inducing diuresis for treating strangurtia.
Corn stigma：It is sweet, light, it is mild-natured, return bladder, liver, gallbladder channel.Diuresis, expels the heat-evil, flat liver, cholagogic.Control nephritic dropsy, pin
Gas, icterohepatitis, hypertension, cholecystitis, gall stone, diabetes, hematemesis and epistaxis, nasosinusitis, acute mastitis.In Chinese medicine, corn stigma is again
Claim " dragon ", there is extensive prevention and health care purposes.There is cool blood, purge heat, internal damp and hot gas can be removed.It can also profit
Water, detumescence.Corn stigma, Gan Ping, energy inducing diuresis for removing edema expels the heat-evil, flat liver cholagogic, moreover it is possible to antiallergy, treatment ephritis, oedema, hepatitis, height
Blood pressure, cholecystitis, gall stone, diabetes, nasosinusitis, mastitis etc..Corn stigma has diuresis to people, can increase chloride
Discharge rate, its diuresis are the outer property of kidney, so have certain curative effect to the oedema that a variety of causes causes, although it can be with
For treating chronic nephritis or nephrotic syndrome, but it is not too strong to act on.Corn stigma has dilating effect to peripheral vessel, so having
Weaker hypotensive effect.Corn stigma can promote bile excretion, so the chronic gall-bladder without complication can be used for as cholagogic
Scorching or bile discharges the cholangitis of obstacle.Coordinate with the oriental wormwood of removing jaundice, jaundice caused by hepatitis can also be treated
Pyrrosia lingua, sweet, hardship, cold nature；Enter lung, bladder warp.The effect such as have promoting diuresis for stranguria, clearing lung-heat to expel the heat-evil.Energy clearing away damp-heat, diuresis are led to
Beautiful jade, to control knife wound, scald, de- power deficient.
Canton love-pea vine：Complete stool is dried for legume abrus cantoniensis Hance.Cool in nature, sweet, slight bitter is nontoxic；The thoughts of returning home, lung, liver,
Stomach.There is removing dampness through diuresis and removing jaundice, it is clearing heat and detoxicating, the effect of dispersing the depressed liver-qi and alleviating pain.It is usually used in damp and hot yellow subcutaneous ulcer, side of body rib is not relaxed, epigastric distending pain, acute mastitis
Swell and ache.Canton love-pea vine can also save to carry out Baoshang and make dietotherapy in Fascinating face rainy season.
Poria cocos：It is sweet, light, mild-natured, enter the heart, lung, the spleen channel；With eliminating dampness and diuresis, strengthening the spleen and stomach, effect of antitoxic heart-soothing and sedative.
Poria cocos mild in medicine property and, dampness removing and do not hinder healthy tendency, difficult urination, oedema turgor, phlegm and retained fluid can be controlled and coughed inverse, inverse, vomiting during early pregnancy of vomitting, had loose bowels, lose
The disease such as essence, stranguria with turbid discharge, palpitation with fear, forgetful.Contained pachymic acid has the effect of strengthen immunity, antitumor and calm, hypoglycemic etc..
Can be relaxed gastrointestinal smooth muscle, gastric acid secretion inhibiting, the effects such as prevent necrosis of liver cells, antibacterial.
Asiatic plantain：It is sweet, light, cold nature；Return lung Jing；Liver Channel；Kidney channel；Bladder warp.Main difficult urination；Stranguria with turbid discharge under band；Water
Swelling is expired；Summer-heat and damp rush down dysentery；Hot eyes is hidden from view；The hot cough and asthma of phlegm.With antidiarrheal, diuresis, eliminating the phlegm, antibechic, the effect of relievining asthma etc..
Herba lygodii：It is cold in nature, it is sweet, salty, return bladder warp, small intestinl channel；It is clearing heat and detoxicating, promoting diuresis for stranguria.Urinary tract infections is controlled, is urinated
Road calculus, gonorrhoea, leukorrhea, hepatitis, nephritic dropsy, abscess of throat, mumps, enteritis, dysentery, skin eczema, herpes zoster.
Cogongrass rhizome：It is sweet, it is cold in nature；The thoughts of returning home, lung, stomach, bladder warp；Property delay into blood, drop and have liter.Cooling blood and hemostasis, heat-clearing solution
Poison.For spitting blood, hematuria, heat gonorrhea, oedema, jaundice, difficult urination, pyreticosis polydipsia, stomach energy is vomitted the sound of vomiting, cough.
Calculus grass：Promoting qi circulation and relieving pain, food digesting stomach fortifying, only dysentery, invigorating spleen to remove dampness, dissipate the stasis of blood.
Centipeda minima：Pig dung grass is an alias of Centipeda minima, with wind-dispelling, cold dispelling, wins wet, goes screen, leads to nasal obstruction
Effect.
Corydalis tuber：Warm in nature, taste is pungent, it is nontoxic；Return liver, stomach, the heart, lung, the spleen channel.There are promoting blood circulation, promoting the circulation of qi, effect of pain relieving.For
Chest side of body, epigastric pain, chest impediment and cardialgia, Amenorrhea dysmenorrhoea, postpartum stasis, tumbling and swelling.
The selected Chinese medicine material medicine the membrane of a chicken's gizzard, Desmodium styracifolium, corn stigma are monarch drug in a prescription, and clearing heat and detoxicating, fossil exclusion, profit are played altogether
Urine, the effect of improve patient's physique, while effectively clearing heat and detoxicating, fossil exclusion, improve patient's physique, to effect a radical cure bladder
Calculus.Give birth to the Radix Astragali, give birth to Hangzhoupro Chinese herbaceous peony, nitre, mirabilite, the wind-weed, pyrrosia lingua, Canton love-pea vine for ministerial drug, gain monarch drug in a prescription drug effect.Wherein raw Hangzhoupro Chinese herbaceous peony,
The wind-weed, Canton love-pea vine, pyrrosia lingua can gain monarch drug in a prescription it is clearing heat and detoxicating the effect of, make the spansule effectively clearing heat and detoxicating, so as to remaining
The more preferable fossil exclusion of medicine；The effect of raw Hangzhoupro Chinese herbaceous peony, Canton love-pea vine also have dispersing the depressed liver-qi and alleviating pain, can mitigate the pain in affected part.Nitre, Piao
Nitre has gain monarch drug in a prescription fossil exclusion, improves effect of physique.Canton love-pea vine, the raw Radix Astragali, pyrrosia lingua have gain monarch drug in a prescription torr sore myogenic,
Effect of Li Shui, can preferably mitigate patient suffering, improve the compliance of patient.Poria cocos, Asiatic plantain, Herba lygodii, cogongrass
Root, calculus grass are altogether adjutant, with coordinating that monarch-minister drug is clearing heat and detoxicating, fossil exclusion, diuresis, the effect of improve patient's physique.Its
Middle Asiatic plantain, Herba lygodii are clearing heat and detoxicating, diuresis and stone expeling, and Poria cocos, cogongrass rhizome, calculus grass have strengthen immunity, promoting blood circulation and removing blood stasis
The effect for promoting other drugs to absorb., altogether to make medicine, the through diseased region of all medicines is led in guide, and is had for Centipeda minima, corydalis tuber
The effect of coordinating the drug actions of a prescription.Above all medicines share, with good clearing heat and detoxicating, fossil exclusion, the drug effect for improving patient's physique, and
And all medicine phases are mutually nursed one's health, and body is had no adverse effects, using safety.The present invention spansule be pure Chinese medicinal preparation, selected medicine
Material compatibility is suitable, and is made using modern advanced medical pharmaceutical technology, and work fast, good stability is especially suitable for bladder
The patient of calculus uses.
The stable preparation process of pastille micropill is high, and broken ball and dust are few, high income containing pill.The system of thing sustained release pellet
, as slow-release material solvent, overcome using simple organic solvent coating electrostatic problem for using 70% ~ 80% alcohol；And be sustained
Micropill technique can simultaneously be operated with pastille micropill technique in same equipment, hence it is evident that improve production efficiency.In whole technique not
Using virose organic reagent, environmental protection, good stability.
Beneficial effects of the present invention
The present invention overcomes the defect of traditional treatment calculus, from calculus, balance blood pH is eliminated, improves calculus physique method
Undertaking therapy vesical calculus.Using clearing heat and detoxicating, fossil exclusion, the treatment method for improving patient's physique.And all medicine phases intermodulation
Reason, has no adverse effects, using safety to body.Poria cocos, cogongrass rhizome, calculus grass have strengthen immunity, promoting blood circulation in selected all medicines
Stagnation resolvation promotes effect that other drugs absorb.Can preferably promote other drugs to play curative effect, immunity of organisms be improved, so as to promote
Enter patient and preferably recover physique.The effect of raw Hangzhoupro Chinese herbaceous peony, Canton love-pea vine also have dispersing the depressed liver-qi and alleviating pain, the pain that can mitigate affected part improves trouble
The compliance of person.The spansule of the present invention is pure Chinese medicinal preparation, and selected medicinal material compatibility is suitable, and using modern advanced medicine
Pharmaceutical technology is made, work fast, good stability, and the patient for being especially suitable for vesical calculus uses.
The preparation of sustained release pellet, as slow-release material solvent, is overcome using simple organic molten using 70% ~ 80% alcohol
Agent coating electrostatic problem；And sustained release pellet technique can simultaneously be operated with pastille micropill technique in same equipment, hence it is evident that improve
Production efficiency.Virose organic reagent, environmental protection, good stability are provided without in whole technique.
Not only the effective ratio of medicine is high for the traditional Chinese medicine slow-releasing capsule, facilitates medication, and realizes persistently, slowly releasing in vivo
Medicine is put, blood concentration is steady, fluctuates little, also have certain protection to the internal organs of patient.Not only increase patient compliance, moreover it is possible to
The survival rate of medication patient is improved, auxiliary material and packing cost is reduced, is conducive to big production.
Specific embodiment
According to following embodiments, the present invention may be better understood.However, as it will be easily appreciated by one skilled in the art that real
Apply the specific material proportion described by example, process conditions and its result be merely to illustrate the present invention and should not also without limitation on
The present invention described in detail in claims.
Embodiment 1
A kind of traditional Chinese medicine slow-releasing capsule for treating vesical calculus, the Chinese medicine material medicine of the traditional Chinese medicine slow-releasing capsule includes：Chicken
Interior golden 50 parts, raw 20 parts of the Radix Astragali, raw 20 parts of Hangzhoupro Chinese herbaceous peony, 25 parts of the wind-weed, 1 part of nitre, 1 part of mirabilite, 40 parts of Desmodium styracifolium, corn stigma 40
Part, 30 parts of pyrrosia lingua, 35 parts of Canton love-pea vine, 45 parts of Poria cocos, 35 parts of Asiatic plantain, 35 parts of Herba lygodii, 20 parts of cogongrass rhizome, calculus grass 25
Part, 35 parts of Centipeda minima, 30 parts of corydalis tuber, 15 parts of talcum powder, 25 parts of crystallite methylcellulose, 20 parts of ethyl cellulose, glyceride 3
Part, 2 parts of polyethylene glycol.
A kind of preparation method of the traditional Chinese medicine slow-releasing capsule for treating vesical calculus, comprises the steps：
1）Get the raw materials ready, get the raw materials ready according to the component and weight fraction of a kind of traditional Chinese medicine slow-releasing capsule for treating vesical calculus, the membrane of a chicken's gizzard is crushed
400 mesh sieves are crossed, nitre, mirabilite crushed respectively 100 mesh sieves, and microcrystalline cellulose, talcum powder crushed respectively 80 mesh sieves；
2）The extraction of Chinese medicine material pharmaceutically active ingredient, by water of the parts by weight for 10 times of Chinese medicine material medicine Chinese medicine extracting tank is added
In, open stirring, by Chinese medicine material medicine give birth to the Radix Astragali, raw Hangzhoupro Chinese herbaceous peony, the wind-weed, Desmodium styracifolium, corn stigma, pyrrosia lingua, Canton love-pea vine, Poria cocos,
Asiatic plantain, Herba lygodii, cogongrass rhizome, calculus grass, Centipeda minima, corydalis tuber are added in Chinese medicine extracting tank, by Chinese medicine extracting tank
Temperature of charge be heated to 95 ~ 100 DEG C, constant temperature 30min, 80 mesh are filtered, and take filtrate, filter residue, are Chinese medicine material by parts by weight
The water that 10 times of medicine is added in Chinese medicine extracting tank, opens stirring, and filter residue is added in Chinese medicine extracting tank, by the thing in Chinese medicine extracting tank
Material temperature degree is heated to 95 ~ 100 DEG C, and constant temperature 30min, 80 mesh are filtered, and take filtrate；Merge 2 gained filtrates, be concentrated in vacuo to original
/ 8th of filtrate volume obtain Chinese medical extract；Vacuum concentration process condition is：Pressure is -0.07 ~ -0.08Mpa, temperature is
45~50℃；
3）The preparation of Chinese medicine material pharmaceutically active ingredient pellet core, the membrane of a chicken's gizzard, nitre, mirabilite, Chinese medical extract, crystallite is fine
Dimension element, talcum powder are well mixed to obtain mixture a, add the alcohol that mass concentration is 95 ~ 100% to stir in mixture a
Mixture b, alcohol consumption is 1/3rd of mixture a gross weight numbers, and mixture b is granulated by centrifugal granulator, from
Scheming rotating speed is 200r/min, baking temperature is 40 ~ 45 DEG C；
4）The preparation of Chinese medicine material pharmaceutically active ingredient sustained release pellet, it is using stable fluid bed bottom spray art for coating, ethyl is fine
Dimension element, glyceride, polyethylene glycol mass concentration dissolve for 70% ~ 80% alcohol, obtain Coating Solution, and the consumption of alcohol is ethyl
Cellulose, glyceride, 10 times of polyethylene glycol weight, Coating Solution is sprayed onto into step 3）In gained pellet core, sustained release is made
Micropill；Technological parameter is：EAT be 50 ~ 55 DEG C, temperature of charge be 35 ~ 40 DEG C, feed flow rotating speed be 60rpm, blower fan frequency
For 25Hz, atomizing pressure is 0.12Mpa；
5）Dress capsule, by step 4）Gained sustained release pellet fills capsule by tire bagger, and specification is per weight 0.5g.
Usage and dosage：Orally, one time a day, 3 ~ 5 or follows the doctor's advice every time.
Embodiment 2
A kind of traditional Chinese medicine slow-releasing capsule for treating vesical calculus, the Chinese medicine material medicine of the traditional Chinese medicine slow-releasing capsule includes：Chicken
Interior golden 55 parts, raw 25 parts of the Radix Astragali, raw 25 parts of Hangzhoupro Chinese herbaceous peony, 30 parts of the wind-weed, 3 parts of nitre, 3 parts of mirabilite, 45 parts of Desmodium styracifolium, corn stigma 45
Part, 35 parts of pyrrosia lingua, 40 parts of Canton love-pea vine, 50 parts of Poria cocos, 40 parts of Asiatic plantain, 40 parts of Herba lygodii, 25 parts of cogongrass rhizome, calculus grass 30
Part, 40 parts of Centipeda minima, 35 parts of corydalis tuber, 20 parts of talcum powder, 30 parts of crystallite methylcellulose, 25 parts of ethyl cellulose, glyceride 5
Part, 4 parts of polyethylene glycol.
A kind of preparation method of the traditional Chinese medicine slow-releasing capsule for treating vesical calculus, comprises the steps：
1）Get the raw materials ready, get the raw materials ready according to the component and weight fraction of a kind of traditional Chinese medicine slow-releasing capsule for treating vesical calculus, the membrane of a chicken's gizzard is crushed
400 mesh sieves are crossed, nitre, mirabilite crushed respectively 100 mesh sieves, and microcrystalline cellulose, starch, polysorbate, low substituted hydroxy-propyl are fine
Dimension element, sodium carboxymethyl starch, magnesium stearate crushed respectively 80 mesh sieves；
2）The extraction of Chinese medicine material pharmaceutically active ingredient, by water of the parts by weight for 10 times of Chinese medicine material medicine Chinese medicine extracting tank is added
In, open stirring, by Chinese medicine material medicine give birth to the Radix Astragali, raw Hangzhoupro Chinese herbaceous peony, the wind-weed, Desmodium styracifolium, corn stigma, pyrrosia lingua, Canton love-pea vine, Poria cocos,
Asiatic plantain, Herba lygodii, cogongrass rhizome, calculus grass, Centipeda minima, corydalis tuber are added in Chinese medicine extracting tank, by Chinese medicine extracting tank
Temperature of charge be heated to 95 ~ 100 DEG C, constant temperature 30min, 80 mesh are filtered, and take filtrate, filter residue, are Chinese medicine material by parts by weight
The water that 10 times of medicine is added in Chinese medicine extracting tank, opens stirring, and filter residue is added in Chinese medicine extracting tank, by the thing in Chinese medicine extracting tank
Material temperature degree is heated to 95 ~ 100 DEG C, and constant temperature 30min, 80 mesh are filtered, and take filtrate；Merge 2 gained filtrates, be concentrated in vacuo to original
/ 8th of filtrate volume obtain Chinese medical extract；Vacuum concentration process condition is：Pressure is -0.07 ~ -0.08Mpa, temperature is
45~50℃；
3）The preparation of Chinese medicine material pharmaceutically active ingredient pellet core, the membrane of a chicken's gizzard, nitre, mirabilite, Chinese medical extract, crystallite is fine
Dimension element, talcum powder are well mixed to obtain mixture a, add the alcohol that mass concentration is 95 ~ 100% to stir in mixture a
Mixture b, alcohol consumption is 1/3rd of mixture a gross weight numbers, and mixture b is granulated by centrifugal granulator, from
Scheming rotating speed is 200r/min, baking temperature is 40 ~ 45 DEG C；
4）The preparation of Chinese medicine material pharmaceutically active ingredient sustained release pellet, it is using stable fluid bed bottom spray art for coating, ethyl is fine
Dimension element, glyceride, polyethylene glycol mass concentration dissolve for 70% ~ 80% alcohol, obtain Coating Solution, and the consumption of alcohol is ethyl
Cellulose, glyceride, 10 times of polyethylene glycol weight, Coating Solution is sprayed onto into step 3）In gained pellet core, sustained release is made
Micropill；Technological parameter is：EAT be 50 ~ 55 DEG C, temperature of charge be 35 ~ 40 DEG C, feed flow rotating speed be 60rpm, blower fan frequency
For 25Hz, atomizing pressure is 0.12Mpa；
5）Dress capsule, by step 4）Gained sustained release pellet fills capsule by tire bagger, and specification is per weight 0.8g.
Usage and dosage：Orally, one time a day, 2 ~ 4 or follows the doctor's advice every time.
Embodiment 3
A kind of traditional Chinese medicine slow-releasing capsule for treating vesical calculus, it is characterised in that the Chinese medicine of the traditional Chinese medicine slow-releasing capsule is former
Material medicine includes：52 parts of the membrane of a chicken's gizzard, raw 23 parts of the Radix Astragali, raw 21 parts of Hangzhoupro Chinese herbaceous peony, 26 parts of the wind-weed, 1.2 parts of nitre, 2 parts of mirabilite, Desmodium styracifolium
44 parts, 43 parts of corn stigma, 32 parts of pyrrosia lingua, 37 parts of Canton love-pea vine, 46 parts of Poria cocos, 38 parts of Asiatic plantain, 37 parts of Herba lygodii, cogongrass rhizome 24
Part, 29 parts of calculus grass, 36 parts of Centipeda minima, 33 parts of corydalis tuber, 18 parts of talcum powder, 27 parts of crystallite methylcellulose, ethyl cellulose
22 parts, 4 parts of glyceride, 3 parts of polyethylene glycol.
A kind of preparation method of the traditional Chinese medicine slow-releasing capsule for treating vesical calculus, comprises the steps：
1）Get the raw materials ready, get the raw materials ready according to the component and weight fraction of a kind of traditional Chinese medicine slow-releasing capsule for treating vesical calculus, the membrane of a chicken's gizzard is crushed
400 mesh sieves are crossed, nitre, mirabilite crushed respectively 100 mesh sieves, and microcrystalline cellulose, starch, polysorbate, low substituted hydroxy-propyl are fine
Dimension element, sodium carboxymethyl starch, magnesium stearate crushed respectively 80 mesh sieves；
2）The extraction of Chinese medicine material pharmaceutically active ingredient, by water of the parts by weight for 10 times of Chinese medicine material medicine Chinese medicine extracting tank is added
In, open stirring, by Chinese medicine material medicine give birth to the Radix Astragali, raw Hangzhoupro Chinese herbaceous peony, the wind-weed, Desmodium styracifolium, corn stigma, pyrrosia lingua, Canton love-pea vine, Poria cocos,
Asiatic plantain, Herba lygodii, cogongrass rhizome, calculus grass, Centipeda minima, corydalis tuber are added in Chinese medicine extracting tank, by Chinese medicine extracting tank
Temperature of charge be heated to 95 ~ 100 DEG C, constant temperature 30min, 80 mesh are filtered, and take filtrate, filter residue, are Chinese medicine material by parts by weight
The water that 10 times of medicine is added in Chinese medicine extracting tank, opens stirring, and filter residue is added in Chinese medicine extracting tank, by the thing in Chinese medicine extracting tank
Material temperature degree is heated to 95 ~ 100 DEG C, and constant temperature 30min, 80 mesh are filtered, and take filtrate；Merge 2 gained filtrates, be concentrated in vacuo to original
/ 8th of filtrate volume obtain Chinese medical extract；Vacuum concentration process condition is：Pressure is -0.07 ~ -0.08Mpa, temperature is
45~50℃；
3）The preparation of Chinese medicine material pharmaceutically active ingredient pellet core, the membrane of a chicken's gizzard, nitre, mirabilite, Chinese medical extract, crystallite is fine
Dimension element, talcum powder are well mixed to obtain mixture a, add the alcohol that mass concentration is 95 ~ 100% to stir in mixture a
Mixture b, alcohol consumption is 1/3rd of mixture a gross weight numbers, and mixture b is granulated by centrifugal granulator, from
Scheming rotating speed is 200r/min, baking temperature is 40 ~ 45 DEG C；
4）The preparation of Chinese medicine material pharmaceutically active ingredient sustained release pellet, it is using stable fluid bed bottom spray art for coating, ethyl is fine
Dimension element, glyceride, polyethylene glycol mass concentration dissolve for 70% ~ 80% alcohol, obtain Coating Solution, and the consumption of alcohol is ethyl
Cellulose, glyceride, 10 times of polyethylene glycol weight, Coating Solution is sprayed onto into step 3）In gained pellet core, sustained release is made
Micropill；Technological parameter is：EAT be 50 ~ 55 DEG C, temperature of charge be 35 ~ 40 DEG C, feed flow rotating speed be 60rpm, blower fan frequency
For 25Hz, atomizing pressure is 0.12Mpa；
5）Dress capsule, by step 4）Gained sustained release pellet fills capsule by tire bagger, and specification is per weight 1.0g.
Usage and dosage：Orally, one time a day, 1 ~ 3 or follows the doctor's advice every time.
Embodiment 4
Content uniformity
According to《Chinese Pharmacopoeia》2015 editions（Four）0923 tablet friability inspection technique is checked.Content uniformity under 0103 capsule item
Inspection technique is checked.
Inspection technique：Unless otherwise specified, test sample 10 is taken, the accurately weighed weight of difference pours out content（Must not lose
Softgel shell）, the little grooming of softgel shell only again distinguish accurately weighed softgel shell weight, obtain the tolerant loading amount of every intragranular and average loading amount.Often
Grain loading amount must not be more than 2 compared with average loading amount beyond content uniformity limit, and must not have 11 times of overrun.
Inspection result：Traditional Chinese medicine slow-releasing capsule prepared by embodiment 1 ~ 3 meets regulation.
Embodiment 5
Disintegration time limited
According to《Chinese Pharmacopoeia》2015 editions（Four）Inspection technique inspection under 0921 disintegration time limited inspection technique tablet item.
Apparatus：Using lift disintegration tester.
Inspection technique：Hanging basket is hung on support by the stainless steel shaft of upper end, in immersion 1000ml beakers, and regulation is hung
Screen cloth fills the water that temperature is 37 ± 1 DEG C in beaker bottom 25mm, beaker when basket position makes it drop to low spot, adjusts water level
At the 15mm of underwater, hanging basket top can not be immersed in solution screen cloth when highly making hanging basket rise lofty perch.
Test sample 6 is taken, during the glass tube of above-mentioned hanging basket is put respectively, is started disintegration tester and is checked that each all should be 30
All disintegrations in minute.Can not completely be disintegrated if any 1, should separately take 6 retrials, regulation all should be met.
Inspection result：The gained Chinese medicine composition of embodiment 1 ~ 3 meets regulation.
Embodiment 6
Acute oral toxicity test：
The drug release capsules of the treatment vesical calculus are pressed《Chinese medicine, natural drug studies on acute toxicity guideline》（【Z】
GPT2-1）" acute oral toxicity once limit the quantity test method(s) " experiment, chooses healthy adult rat, body weight 180-220g, 18,
Male and female half and half, with sex mouse mesosome heavy phase difference the 10% of average weight is must not exceed.Experiment starts fasting in front 16h, then right
Adult rat is arbitrarily equally divided into 3 groups and is administered with oral administration by gavage, gives the medicine of embodiment 1 to 3 respectively, gavage metering with
5000mg/Kg batheroom scales, then proceed to fasting 3 days, and test mice overall health of patients, diet, drinking-water, body weight increase are normal, not
Obvious intoxicating phenomenon and the phenomena of mortality such as appearance is trembled, twitches, salivating, suffering from diarrhoea, drowsiness, stupor, place's post mortem is without substantially different
Often, judge the medicine to the nontoxic level in the true border of adult mice acute oral toxicity.
Embodiment 7
The Toxicity Analysis of the present invention
Vesical calculus model mouse 40 is taken, male rat is, 4 groups are equally divided into, first group is control group, daily normal diet
Feed（10g/ is only）, a kind of traditional Chinese medicine slow-releasing capsule mixing feeding for treating vesical calculus of the preparation of embodiment 1 of second group of addition 30%
Material is fed（10g/ is only）, a kind of traditional Chinese medicine slow-releasing capsule mixing for treating vesical calculus of the preparation of embodiment 2 of the 3rd group of addition 30%
Forage feed（10g/ is only）, a kind of traditional Chinese medicine slow-releasing capsule for treating vesical calculus prepared by the embodiment 3 of the 4th group of addition 30% mixes
Close forage feed（10g/ is only）.Above each group rat puts into the normal diet of abundance daytime and raises.Feeding process observes rat
Form and the state of mind.Administration is put to death for 4 weeks, is taken vesical calculus and is weighed, with the weight of calculus（mg）As evaluation index.
The weight result of calculus see the table below.
Conclusion：Traditional Chinese medicine slow-releasing capsule for treating effect prepared by the edible embodiments of the invention 1 ~ 3 of vesical calculus model mouse is bright
It is aobvious.
The form and state of mind comparative result of feeding process rat see the table below.
| Group | Form and the state of mind |
| First group | Compare normal rat anorexia, hair color flavescence, hair is uneven, lose weight, activity is reduced. |
| Second group | Comparing first group of rat urine volume increases, and spiritual diet activity and hair color are obviously improved. |
| 3rd group | Comparing first group of rat urine volume increases, and spiritual diet activity and hair color are obviously improved. |
| 4th group | Comparing first group of rat urine volume increases, and spiritual diet activity and hair color are obviously improved. |
Conclusion：Traditional Chinese medicine slow-releasing capsule for treating effect prepared by the edible embodiments of the invention 1 ~ 3 of vesical calculus model mouse is bright
It is aobvious.
Claims (7)
1. a kind of traditional Chinese medicine slow-releasing capsule for treating vesical calculus, it is characterised in that the Chinese medicine of the traditional Chinese medicine slow-releasing capsule
Bulk drug includes：50 ~ 55 parts of the membrane of a chicken's gizzard, raw 20 ~ 25 parts of the Radix Astragali, raw 20 ~ 25 parts of Hangzhoupro Chinese herbaceous peony, 25 ~ 30 parts of the wind-weed, 1 ~ 3 part of nitre, Piao
1 ~ 3 part of nitre, 40 ~ 45 parts of Desmodium styracifolium, 40 ~ 45 parts of corn stigma, 30 ~ 35 parts of pyrrosia lingua, 35 ~ 40 parts of Canton love-pea vine, 45 ~ 50 parts of Poria cocos,
35 ~ 40 parts of Asiatic plantain, 35 ~ 40 parts of Herba lygodii, 20 ~ 25 parts of cogongrass rhizome, 25 ~ 30 parts of calculus grass, 35 ~ 40 parts of Centipeda minima, prolong
30 ~ 35 parts of Hu rope, 15 ~ 20 parts of talcum powder, 25 ~ 30 parts of crystallite methylcellulose, 20 ~ 25 parts of ethyl cellulose, 3 ~ 5 parts of glyceride,
2 ~ 4 parts of polyethylene glycol.
2. a kind of traditional Chinese medicine slow-releasing capsule for treating vesical calculus according to claim 1, it is characterised in that the traditional Chinese medicine slow-releasing
The Chinese medicine material medicine of capsule includes：50 parts of the membrane of a chicken's gizzard, raw 20 parts of the Radix Astragali, raw 20 parts of Hangzhoupro Chinese herbaceous peony, 25 parts of the wind-weed, nitre 1
Part, 1 part of mirabilite, 40 parts of Desmodium styracifolium, 40 parts of corn stigma, 30 parts of pyrrosia lingua, 35 parts of Canton love-pea vine, 45 parts of Poria cocos, 35 parts of Asiatic plantain, sea
35 parts of Jinsha grass, 20 parts of cogongrass rhizome, 25 parts of calculus grass, 35 parts of Centipeda minima, 30 parts of corydalis tuber, 15 parts of talcum powder, crystallite first are fine
25 parts of dimension element, 20 parts of ethyl cellulose, 3 parts of glyceride, 2 parts of polyethylene glycol.
3. a kind of traditional Chinese medicine slow-releasing capsule for treating vesical calculus according to claim 1, it is characterised in that the traditional Chinese medicine slow-releasing
The Chinese medicine material medicine of capsule includes：55 parts of the membrane of a chicken's gizzard, raw 25 parts of the Radix Astragali, raw 25 parts of Hangzhoupro Chinese herbaceous peony, 30 parts of the wind-weed, nitre 3
Part, 3 parts of mirabilite, 45 parts of Desmodium styracifolium, 45 parts of corn stigma, 35 parts of pyrrosia lingua, 40 parts of Canton love-pea vine, 50 parts of Poria cocos, 40 parts of Asiatic plantain, sea
40 parts of Jinsha grass, 25 parts of cogongrass rhizome, 30 parts of calculus grass, 40 parts of Centipeda minima, 35 parts of corydalis tuber, 20 parts of talcum powder, crystallite first are fine
30 parts of dimension element, 25 parts of ethyl cellulose, 5 parts of glyceride, 4 parts of polyethylene glycol.
4. a kind of traditional Chinese medicine slow-releasing capsule for treating vesical calculus according to claim 1, it is characterised in that the traditional Chinese medicine slow-releasing
The Chinese medicine material medicine of capsule includes：52 parts of the membrane of a chicken's gizzard, raw 23 parts of the Radix Astragali, raw 21 parts of Hangzhoupro Chinese herbaceous peony, 26 parts of the wind-weed, nitre
1.2 parts, 2 parts of mirabilite, 44 parts of Desmodium styracifolium, 43 parts of corn stigma, 32 parts of pyrrosia lingua, 37 parts of Canton love-pea vine, 46 parts of Poria cocos, Asiatic plantain 38
Part, 29 parts of 37 parts of Herba lygodii, 24 parts of cogongrass rhizome, calculus grass, 36 parts of Centipeda minima, 33 parts of corydalis tuber, 18 parts of talcum powder, crystallite
27 parts of methylcellulose, 22 parts of ethyl cellulose, 4 parts of glyceride, 3 parts of polyethylene glycol.
5. the preparation method of a kind of traditional Chinese medicine slow-releasing capsule for treating vesical calculus according to any one of claim 1 ~ 4, its
It is characterised by, comprises the steps：
1）Get the raw materials ready, get the raw materials ready according to the component and weight fraction of a kind of traditional Chinese medicine slow-releasing capsule for treating vesical calculus, the membrane of a chicken's gizzard is crushed
400 mesh sieves are crossed, nitre, mirabilite crushed respectively 100 mesh sieves, and microcrystalline cellulose, talcum powder crushed respectively 80 mesh sieves；
2）The extraction of Chinese medicine material pharmaceutically active ingredient, by water of the parts by weight for 10 times of Chinese medicine material medicine Chinese medicine extracting tank is added
In, open stirring, by Chinese medicine material medicine give birth to the Radix Astragali, raw Hangzhoupro Chinese herbaceous peony, the wind-weed, Desmodium styracifolium, corn stigma, pyrrosia lingua, Canton love-pea vine, Poria cocos,
Asiatic plantain, Herba lygodii, cogongrass rhizome, calculus grass, Centipeda minima, corydalis tuber are added in Chinese medicine extracting tank, by Chinese medicine extracting tank
Temperature of charge be heated to 95 ~ 100 DEG C, constant temperature 30min, 80 mesh are filtered, and take filtrate, filter residue, are Chinese medicine material by parts by weight
The water that 10 times of medicine is added in Chinese medicine extracting tank, opens stirring, and filter residue is added in Chinese medicine extracting tank, by the thing in Chinese medicine extracting tank
Material temperature degree is heated to 95 ~ 100 DEG C, and constant temperature 30min, 80 mesh are filtered, and take filtrate；Merge 2 gained filtrates, be concentrated in vacuo to original
/ 8th of filtrate volume obtain Chinese medical extract；
3）The preparation of Chinese medicine material pharmaceutically active ingredient pellet core, the membrane of a chicken's gizzard, nitre, mirabilite, Chinese medical extract, crystallite is fine
Dimension element, talcum powder are well mixed to obtain mixture a, add the alcohol that mass concentration is 95 ~ 100% to stir in mixture a
Mixture b, alcohol consumption is 1/3rd of mixture a gross weight numbers, and mixture b is granulated by centrifugal granulator, from
Scheming rotating speed is 200r/min, baking temperature is 40 ~ 45 DEG C；
4）The preparation of Chinese medicine material pharmaceutically active ingredient sustained release pellet, it is using stable fluid bed bottom spray art for coating, ethyl is fine
Dimension element, glyceride, polyethylene glycol mass concentration dissolve for 70% ~ 80% alcohol, obtain Coating Solution, and the consumption of alcohol is ethyl
Cellulose, glyceride, 10 times of polyethylene glycol weight, Coating Solution is sprayed onto into step 3）In gained pellet core, sustained release is made
Micropill；
5）Dress capsule, by step 4）Gained sustained release pellet fills capsule by tire bagger, and specification is per 0.5 ~ 1.0g of weight.
6. the preparation method of a kind of traditional Chinese medicine slow-releasing capsule for treating vesical calculus according to claim 5, it is characterised in that
Vacuum concentration process condition is in the extraction step of the Chinese medicine material pharmaceutically active ingredient：Pressure is -0.07 ~ -0.08Mpa, temperature
Spend for 45 ~ 50 DEG C.
7. the preparation method of a kind of traditional Chinese medicine slow-releasing capsule for treating vesical calculus according to claim 5, it is characterised in that
The step 4）The coating process parameters of sustained release pellet are：EAT is 50 ~ 55 DEG C, and temperature of charge is 35 ~ 40 DEG C, and feed flow turns
Speed is 60rpm, and blower fan frequency is 25Hz, and atomizing pressure is 0.12Mpa.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN112402475A (en) * | 2019-08-20 | 2021-02-26 | 李连福 | Traditional Chinese medicine composition for reducing uric acid and blood pressure |
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| CN101700384A (en) * | 2009-11-13 | 2010-05-05 | 黄远吉 | Traditional Chinese medicine composition for treating renal calculus and vesical calculus |
| CN103735900A (en) * | 2013-12-30 | 2014-04-23 | 广西梧州制药（集团）股份有限公司 | Calculus-suppressing and pain-alleviating Chinese medicinal composition and preparation method thereof |
| CN103816411A (en) * | 2013-12-05 | 2014-05-28 | 孔祥侠 | Medicine for treating gallstones and preparation method thereof |
| CN104398998A (en) * | 2014-12-10 | 2015-03-11 | 李穆 | Traditional Chinese medicine composition for treating urinary calculi |
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2017
- 2017-03-21 CN CN201710168082.4A patent/CN106620367A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101700384A (en) * | 2009-11-13 | 2010-05-05 | 黄远吉 | Traditional Chinese medicine composition for treating renal calculus and vesical calculus |
| CN103816411A (en) * | 2013-12-05 | 2014-05-28 | 孔祥侠 | Medicine for treating gallstones and preparation method thereof |
| CN103735900A (en) * | 2013-12-30 | 2014-04-23 | 广西梧州制药（集团）股份有限公司 | Calculus-suppressing and pain-alleviating Chinese medicinal composition and preparation method thereof |
| CN104398998A (en) * | 2014-12-10 | 2015-03-11 | 李穆 | Traditional Chinese medicine composition for treating urinary calculi |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN112402475A (en) * | 2019-08-20 | 2021-02-26 | 李连福 | Traditional Chinese medicine composition for reducing uric acid and blood pressure |
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