Be used for pharmaceutical composition of gastroptosis and preparation method thereof
1, technical field
The invention belongs to medical technical field, be specifically related to a kind of pharmaceutical composition that is used for gastroptosis and preparation method thereof.
2, background technology
Gastroptosis is that body of stomach drops to the following position of the physiology minimum rate of accumulation, is a kind of functional syndrome.How forfeit one's integrity because of chronic dietary, or overstrain, gas descends in causing, due to the abnormal ascending-descending of QI.The patient feels abdominal distention (food postemphasis, flat crouching alleviates), feels sick, belch, stomachache (aperiodicity and rhythmicity, pain character and degree alter a great deal), and idol has constipation, diarrhoea, or replaces property diarrhoea and constipation.Be common in that the bodily form is become thin, stature is slender, old people, grand multipara, have bad physiques, and moved the people of abdominal operation,, the dirty sagging phenomenon of stomach takes place more easily because these people's abdominal muscles tension force is relatively poor.
At present, the treatment gastroptosis does not have specific drug.The doctor is after getting rid of Differential Diagnosiss such as dirty disease of stomach such as gastric ulcer, gastritis, tumor, to " medicine " under " disease "; Promptly handle at symptom; As with in the medicine and gastric acid, remove the glutted or belch of upper abdomen, symptom such as feel sick, and use the digestant facilitating digestion.Available in case of necessity stomacher auxiliary treatment, the massage that also available temperature is processed strengthens the tension force of stomach, alleviates the sagging symptom that causes.
The traditional Chinese medical science is thought that gastroptosis is deficiency of spleen-QI and stomach-QI, sinking of QI of middle-JIAO, elevate a turnable ladder is unable and is caused.The normal methods such as spleen invigorating, QI invigorating, ascending that adopt are treated, and reach the purpose for the treatment of both the principal and secondary aspects of a disease.Therefore, exploitation Chinese patent medicine evident in efficacy has become scientific research personnel's target.
Radix Bupleuri is the dry root of umbelliferae bupleurum Bupleurum chinense DC. or Radix Bupeuri Scorzonerfolii. Bupleurumscorzonerifolium Willd..Bitter in the mouth, cold nature.Return liver, gallbladder meridian.Reconciling superficies and interior is arranged, soothing the liver, the effect of yang invigorating.Be used for cold, fever, alternate attack of chill and fever, distending pain in the chest and hypochondrium, menoxenia, uterine prolapse, proctoptosis.
The Rhizoma Pinelliae is the dry tuber of aroid Rhizoma Pinelliae Pinellia ternata (Thunb.) Breit..Acrid in the mouth, warm in nature.Return spleen, stomach, lung, warp.Drying dampness to eliminate phlegm is arranged, stopping nausea and vomiting by lowering the adverse flow of QI, the effect of dissolving lump and resolving mass.Be used for the abundant expectoration cough with asthma, the phlegm retention vertigo and palpitation, dizziness due to wind-phlegm, the syncope due to accumulation of phlegm headache, vomiting regurgitation, breast gastral cavity painful abdominal mass is vexed; Give birth to external treatment carbuncle sucutaneous nodule.Rhizoma Pinelliae is the processed product of the Rhizoma Pinelliae, and its concocting method is soaked with cold water and floated a few days for getting the clean Rhizoma Pinelliae, avoid Exposure to Sunlight, bubble is after 10 days, when playing foam, per 100 jin of Rhizoma Pinelliaes add 2 jin of Alumens, steep and change water again after 1 day, after extremely mouth is tasted spicy sense is arranged slightly, it is well-done altogether to add Alumen and water, take out, dry in the air to sixty percent and do, cut into slices behind the moistening, dry, get final product.
Caulis Perillae is the dry stem of labiate Folium Perillae Perilla frutescens (L.) Britt..Acrid in the mouth, warm in nature.Return lung, spleen channel.Regulating the flow of QI to ease the stomach is arranged, pain relieving, antiabortive effect.It is vexed to be used for the chest and diaphragm painful abdominal mass, gastralgia, belch vomiting, frequent fetal movement.
Herba Hedyotidis Diffusae is the herb of Maguireothamnus speciosus Herba Hedyotidis Diffusae Hedyotis diffusa Willd..Cool in nature, sweet in the mouth, light.Heat-clearing and toxic substances removing is arranged, the effect of diuresis of blood circulation promoting.Be used for tonsillitis, pharyngolaryngitis, urinary tract infection, pelvic inflammatory disease, appendicitis, hepatitis, bacillary dysentery, venom, tumor.Modern pharmacological research confirms that Herba Hedyotidis Diffusae has the effect of anti-inflammation, antitumor, antiviral, raise immunity.
At present, utilize Radix Bupleuri, Rhizoma Pinelliae and Caulis Perillae, or Radix Bupleuri, Rhizoma Pinelliae, Caulis Perillae and Herba Hedyotidis Diffusae interaction, composition of prescription is used to prepare the medicine for the treatment of gastroptosis, does not appear in the newspapers as yet.
3, summary of the invention
The object of the present invention is to provide a kind of preparation treatment gastroptosis that is used for, disease sees that gastral cavilty distending pain, belch noisy prescription science, preparation are simple, the pharmaceutical composition of determined curative effect.
Another object of the present invention is to provide this preparation of drug combination method.
The spleen is the source of growth and development, and stomach is a reservoir of food and drink, and the two is with placed in the middle burnt, and the master digests and assimilates altogether.Temper should rise, and gastric qi should be fallen, rising-falling tone and then in burnt balance.Owing to deficiency of QI in middle-JIAO, unable support stomach internal organs causes the generation of the stagnation of QI, phlegm retention, blood stasis to gastroptosis on the other hand owing to deficiency of QI in middle-JIAO on the one hand, the pathological change of the domination of pathogen in various degree occurs.Go back in addition because of clear QI failing to ascend, turbid YIN failing to descend, constipation, FU QI being obstructed, hot and suffocating criminal's stomach, thus there is gastric abscess to expand, diseases such as belch.
Pharmaceutical composition of the present invention is according to the theoretical composition of prescription of Chinese medicine and pharmacy: the Radix Bupleuri bitter in the mouth, cold nature is returned liver, gallbladder meridian, can gently rise clearly diffusing, again can catharsis, have the dispersing the stagnated live-QI to relieve the stagnation of QI heat clearing away, the stagnate function of gas of regulating gastointestinal is monarch drug; The Rhizoma Pinelliae suffering, temperature is gone into the taste warp, and merit is apt to dissolving lump and resolving mass, stopping nausea and vomiting by lowering the adverse flow of QI, drying dampness to eliminate phlegm is used for disorder of stomach-QI, and breast gastral cavity painful abdominal mass is vexed, and vomiting and nausea etc. have and close stomach stopping nausea and vomiting by lowering the adverse flow of QI function preferably, are ministerial drug, during the assistance monarch drug is regulated the flow of vital energy and closed; Caulis Perillae regulating QI to remove the stagnation stomach function regulating is controlled the gastral cavilty distension; That the three share is soothing the liver, eliminating stagnation, pleasant, stomach function regulating, stopping nausea and vomiting by lowering the adverse flow of QI, can be used for gastroptosis and follows disease.
To be the inventor through a large amount of experiments grope to sum up the consumption of making the crude drug of the contained composition and effectiveness of pharmaceutical composition of the present invention draws, and it consists of: 5~15 parts of Radix Bupleuri, 6~18 parts of Rhizoma Pinelliae, 5~15 parts of Caulis Perillaes.
The composition of making the crude drug of the contained composition and effectiveness of pharmaceutical composition of the present invention is preferably:
7~12 parts of Radix Bupleuri, 10~15 parts of Rhizoma Pinelliae, 7~12 parts of Caulis Perillaes.
Make the contained composition and effectiveness of pharmaceutical composition of the present invention crude drug composition more preferably:
9 parts of Radix Bupleuri, 12 parts of Rhizoma Pinelliae, 9 parts of Caulis Perillaes.
In order to make the crude drug of making the contained composition and effectiveness of pharmaceutical composition of the present invention better bring into play drug effect, the invention provides following preparation technology, but be not limited only to following method:
Take by weighing Radix Bupleuri, Rhizoma Pinelliae and Caulis Perillae, decoct with water, amount of water is 4~10 times of amounts of medical material, decocting time is 1~3 hour, and merge extractive liquid, filters, it is 1.10~1.20 that the filtrate heating is concentrated into relative density, and adding ethanol is 50%~80% to containing the alcohol amount, and cold preservation is left standstill, filter, decompression filtrate recycling ethanol is not distinguished the flavor of to there being alcohol, and continues to be concentrated into thick paste, drying, pulverize, add adjuvant and make preparation.
Above-mentioned preparation method can be preferably following steps:
Take by weighing Radix Bupleuri, Rhizoma Pinelliae and Caulis Perillae, decoct with water secondary, add 10 times of amounts of water for the first time, decocted 3 hours, and added 8 times of amounts of water for the second time, decocted 2 hours, merge extractive liquid, filters, and it is 1.15~1.18 that the filtrate heating is concentrated into relative density, adding ethanol is 60% to containing the alcohol amount, and cold preservation was left standstill 24 hours, filtered, decompression filtrate recycling ethanol is not distinguished the flavor of to there being alcohol, and continues to be concentrated into thick paste, drying, pulverize, add adjuvant and make preparation.
The crude drug of making the contained composition and effectiveness of pharmaceutical composition of the present invention also can contain Herba Hedyotidis Diffusae, strengthens the curative effect of inflammation, ulcer etc. in the treatment gastropathy, the consisting of of each crude drug:
5~15 parts of Radix Bupleuri, 6~18 parts of Rhizoma Pinelliae, 5~15 parts of Caulis Perillaes, 10~30 parts of Herba Hedyotidis Diffusaes.
The composition of making the crude drug of the contained composition and effectiveness of pharmaceutical composition of the present invention is preferably:
7~12 parts of Radix Bupleuri, 10~15 parts of Rhizoma Pinelliae, 7~12 parts of Caulis Perillaes, 15~25 parts of Herba Hedyotidis Diffusaes.
Make the contained composition and effectiveness of pharmaceutical composition of the present invention crude drug composition more preferably:
9 parts of Radix Bupleuri, 12 parts of Rhizoma Pinelliae, 9 parts of Caulis Perillaes, 20 parts of Herba Hedyotidis Diffusaes.
The invention described above preparation of drug combination method can be:
Take by weighing Radix Bupleuri, Rhizoma Pinelliae, Caulis Perillae and Herba Hedyotidis Diffusae, decoct with water together, amount of water is 4~10 times of amounts of medical material, decocting time is 1~3 hour, and merge extractive liquid, filters, it is 1.10~1.20 that the filtrate heating is concentrated into relative density, and adding ethanol is 50%~80% to containing the alcohol amount, and cold preservation is left standstill, filter, decompression filtrate recycling ethanol is not distinguished the flavor of to there being alcohol, and continues to be concentrated into thick paste, drying, pulverize, add adjuvant and make preparation.
Above-mentioned preparation method can be preferably following steps:
Take by weighing Radix Bupleuri, Rhizoma Pinelliae, Caulis Perillae and Herba Hedyotidis Diffusae, decoct with water secondary together, add 10 times of amounts of water for the first time, decocted 3 hours, and added 8 times of amounts of water for the second time, decocted 2 hours, merge extractive liquid, filters, and it is 1.15~1.18 that the filtrate heating is concentrated into relative density, adding ethanol is 60% to containing the alcohol amount, and cold preservation was left standstill 24 hours, filtered, decompression filtrate recycling ethanol is not distinguished the flavor of to there being alcohol, and continues to be concentrated into thick paste, drying, pulverize, add adjuvant and make preparation.
The crude drug of making the contained composition and effectiveness of pharmaceutical composition of the present invention is by weight as proportioning, when producing, can or reduce according to the corresponding proportion increase, as large-scale production can kilogram be unit, or be unit with the ton, small-scale production also can restrain and be unit, and weight can increase or reduce.The weight proportion of pharmaceutical composition crude drug of the present invention obtains through science screening, and for especial patient, the ratio of can corresponding adjustment forming increases or reduce being no more than 100%.
Pharmaceutical composition of the present invention has the effect of stopping nausea and vomiting by lowering the adverse flow of QI, intestinal stasis relieving heat clearing away, is used for gastroptosis, and disease is seen gastral cavilty distending pain, the noisy person of belch.
Pharmaceutical composition of the present invention can be mixed and made into clinically any or pharmaceutically acceptable dosage form, preferred oral preparation with one or more pharmaceutically acceptable carriers.Be used for when oral, can be made into conventional solid preparation, as tablet, capsule, pill, granule etc.; Also can be made into oral liquid, as oral solution, oral suspensions, syrup etc.Tablet means disk shape or the special-shaped flaky solid preparation that medicine and the auxiliary materials and mixing compacting that suits form, based on oral ordinary tablet, other has buccal tablet, Sublingual tablet, mouth paster, chewable tablet, dispersible tablet, fuse, effervescent tablet, slow releasing tablet, controlled release tablet and enteric coatel tablets etc.Capsule means medicine or is added with the adjuvant filling in Capsules or be sealed in solid preparation in the soft capsule material, according to its dissolving and release characteristics, can be divided into hard capsule (being commonly referred to as capsule), soft capsule (soft gelatin capsule), slow releasing capsule, controlled release capsule and enteric coated capsule etc.Pill means medicine and suitable adjuvant uniform mixing, and the spherical or near-spherical solid preparation so that proper method is made comprises drop pill, sugar pill, piller etc.Granule means that medicine and suitable adjuvant make the dried particles shape preparation with certain particle size, can be divided into soluble particles (being commonly referred to as granule), mix suspension grain, effervescent granule, enteric coated particles, slow-releasing granules and controlled release granule etc.Oral solution means that medicine dissolution makes for oral supernatant liquid preparation in suitable solvent.Oral suspensions means the slightly solubility solid drugs, is dispersed in the liquid medium, makes for oral suspension body preparation, also comprises dry suspension or dense suspension.Syrup means the dense aqueous sucrose solution that contains medicine.
When pharmaceutical composition of the present invention is made oral formulations, can add suitable filler, binding agent, disintegrating agent, lubricant etc.Filler commonly used comprises starch, Icing Sugar, calcium phosphate, calcium sulfate two water things, dextrin, microcrystalline Cellulose, lactose, pregelatinized Starch, mannitol etc.; Typical binders comprises sodium carboxymethyl cellulose, PVP-K30, hydroxypropyl cellulose, starch slurry, methylcellulose, ethyl cellulose, hypromellose, gelling starch etc.; Disintegrating agent commonly used comprises dried starch, polyvinylpolypyrrolidone, cross-linking sodium carboxymethyl cellulose, carboxymethyl starch sodium, low-substituted hydroxypropyl cellulose etc.; Conventional lubricants comprises magnesium stearate, Pulvis Talci, sodium lauryl sulphate, micropowder silica gel etc.
The advantage of pharmaceutical composition of the present invention is:
(1) provide a kind of preparation treatment gastroptosis that is used for, disease is seen gastral cavilty distending pain, the noisy pharmaceutical composition of belch, has increased the clinical application kind, has satisfied clinical needs.
(2) the pharmacology clinical experiment shows, pharmaceutical composition of the present invention can promote the mice gastric emptying, and it is remarkable that clinical experiment tables of data Mingzhi treats the gastroptosis effect, and curative effect that medicine of the present invention reaches is that those of ordinary skills are beyond thought.
(3) pharmaceutical preparation of the present invention is simple, and mass discrepancy is little between the different batches medicine, and drug quality is uniform and stable.
Below example is further set forth the pharmaceutical composition of being made by Radix Bupleuri, Rhizoma Pinelliae and Caulis Perillae (hereinafter to be referred as medicine 1) by experiment, or the beneficial effect of the pharmaceutical composition (hereinafter to be referred as medicine 2) made of Radix Bupleuri, Rhizoma Pinelliae, Caulis Perillae and Herba Hedyotidis Diffusae.
Experimental example 1 pharmaceutical composition of the present invention is to the influence of mice gastric emptying
Animal subject: Kunming mouse, male and female half and half, body weight 18~25g, 70.
Test sample and reagent: the basic, normal, high dosage group of medicine 1 granule, preparation method and prescription are seen embodiment 6;
The basic, normal, high dosage group of medicine 2 granules, preparation method and prescription are seen embodiment 5;
Negative control: dextrin.
Experimental technique: Kunming mouse is divided into 7 groups at random: medicine 1 low dose group (1.8g crude drug/kg), middle dosage group (3.5g crude drug/kg) and dosage group (7.0g crude drug/kg), medicine 2 low dose group (1.5g crude drug/kg), middle dosage group (3.0g crude drug/kg) and high dose group (6.0g crude drug/kg) and blank dextrin (3.1g/kg) matched group.Every group of 10 mices, male and female half and half.
The experiment mice non-fasting is freely drunk water.Medicine 1 granule, medicine 2 granules all are made into 2.6%, 5.2% and 10.4% barium meal with barium sulfate glue; Be made into negative control with dextrin and barium sulfate glue.Each group is all by 0.3ml/kg body weight gastric infusion.Put to death animal behind the administration 1h,, observe the gastric emptying situation with TOSHIBA KXO-30R type-ray machine film making (film making Index A EC is-2).The degree of gastric emptying can be from the X-mating plate size of stomach push away, promptly gastric surface is long-pending more little, gastric barium sulfate is residual few more, gastric emptying is complete more; Gastric surface is long-pending big more, and gastric barium sulfate is residual many more, and gastric emptying is incomplete more.
Statistical method:,, carried out the sxemiquantitative comparison with negative control so the result has been adopted double blinding range estimation method relatively because of the final result of experiment is graphic materials (a molybdenum target X-mating plate).
Experimental result and conclusion:
Compare with negative control group, medicine 1 granule low dose group there is no tangible gastric emptying, and the gastric emptying of middle and high dosage group of medicine 1 granule and the basic, normal, high dosage group of medicine 2 granules is (the long-pending difference in size of gastric surface is obvious) obviously.Show that medicine 1 granule and medicine 2 granules all have than remarkable influence the mice gastric emptying.
The clinical efficacy data of experimental example 2 pharmaceutical compositions of the present invention
Physical data: 156 routine patients, male's 80 examples wherein, women's 76 examples; The oldest 70 years old, minimum 21 years old, average 45 years old; The course of disease the shortest June, the longest 20 years, average 10 years.Be divided into two groups at random, two groups of patients' sex, age, the course of disease are learned by statistics and are handled no significant difference (p>0.05), have comparability.All cases are all made a definite diagnosis through the barivm meal fluoroscopy (screem) of X line.Clinical manifestation mainly contains chronic abdominal pain, abdominal distention, and the food back is obvious, belch pantothenic acid, constipation etc.
Therapeutic Method: oral medicament composition granule agent of the present invention, take medicine 1 for first group, take the dosage that is equivalent to crude drug 30g at every turn, one day 1 dose; Take medicine 2 for second group, take the dosage that is equivalent to crude drug 25g at every turn, one day 2 doses.Take medicine equal 30 days be 1 course of treatment, took for 1 course of treatment after, observe the curative effect after 3 courses of treatment is taken in drug withdrawal 5 days altogether.
Criterion of therapeutical effect: recovery from illness: clinical symptom disappearance, X line barivm meal fluoroscopy (screem) stomach location restore is normal; Produce effects: clinical symptoms obviously alleviates, and X line barivm meal fluoroscopy (screem) stomach rises more than the 6cm on the position; Effectively: clinical symptom relief, it is invalid to rise 3cm~6cm on the X line barivm meal fluoroscopy (screem) stomach position: clinical symptoms remains unchanged, X line barivm meal fluoroscopy (screem) stomach position no change.
Therapeutic outcome: after 3 course of therapy, recovery from illness 14 examples in first group of 78 example, produce effects 31 examples, effective 23 examples, invalid 10 examples, total effective rate 87.2%.In second group of 78 example, 15 examples of fully recovering.Produce effects 35 examples.Effective 22 examples, invalid 6 examples, total effective rate 92.3%.
Conclusion: above clinical experiment result shows that medicine 1 and medicine 2 treatment gastroptosis all have good curative effect.
4, the specific embodiment
The specific embodiment of form is described in further detail foregoing of the present invention by the following examples.But this should be interpreted as that the scope of the above-mentioned theme of the present invention only limits to following embodiment.All technology that realizes based on foregoing of the present invention all belong to scope of the present invention.
Embodiment 1: the preparation of pharmaceutical composition tablet of the present invention
Radix Bupleuri 8g Rhizoma Pinelliae 13g Caulis Perillae 9g Herba Hedyotidis Diffusae 16g
Take by weighing Radix Bupleuri, Rhizoma Pinelliae, Caulis Perillae and Herba Hedyotidis Diffusae, decoct with water secondary, add 10 times of amounts of water for the first time, decocted 3 hours, for the second time add 8 times of amounts of water, decocted merge extractive liquid, 2 hours, filter, it is 1.15~1.18 that the filtrate heating is concentrated into relative density, and adding ethanol is 60% to containing the alcohol amount, cold preservation was left standstill 24 hours, filtered, and decompression filtrate recycling ethanol is to there not being the alcohol flavor, and continuing to be concentrated into thick paste, drying is pulverized, add binding agent, disintegrating agent and lubricant and make granule, drying, compacting is in flakes.
Embodiment 2: the preparation of pharmaceutical composition tablet of the present invention
Radix Bupleuri 12g Rhizoma Pinelliae 15g Caulis Perillae 12g Herba Hedyotidis Diffusae 25g
Take by weighing Radix Bupleuri, Rhizoma Pinelliae, Caulis Perillae and Herba Hedyotidis Diffusae, decoct with water secondary, add 10 times of amounts of water for the first time, decocted 3 hours, for the second time add 8 times of amounts of water, decocted merge extractive liquid, 2 hours, filter, it is 1.15~1.18 that the filtrate heating is concentrated into relative density, and adding ethanol is 60% to containing the alcohol amount, cold preservation was left standstill 24 hours, filtered, and decompression filtrate recycling ethanol is to there not being the alcohol flavor, and continuing to be concentrated into thick paste, drying is pulverized, add binding agent, disintegrating agent and lubricant and make granule, drying, compacting is in flakes.
Embodiment 3: the preparation of medicament composition capsule agent of the present invention
Radix Bupleuri 7g Rhizoma Pinelliae 10g Caulis Perillae 7g Herba Hedyotidis Diffusae 15g
Take by weighing Radix Bupleuri, Rhizoma Pinelliae, Caulis Perillae and Herba Hedyotidis Diffusae, decoct with water secondary, add 10 times of amounts of water for the first time, decocted 3 hours, and added 8 times of amounts of water for the second time, decocted 2 hours, merge extractive liquid, filters, and it is 1.15~1.18 that the filtrate heating is concentrated into relative density, adding ethanol is 60% to containing the alcohol amount, and cold preservation was left standstill 24 hours, filtered, decompression filtrate recycling ethanol is not distinguished the flavor of to there being alcohol, and continues to be concentrated into thick paste, drying, pulverize, add binding agent and make granule, the hard capsule of packing into.
Embodiment 4: the preparation of medicament composition capsule agent of the present invention
Radix Bupleuri 10g Rhizoma Pinelliae 14g Caulis Perillae 8g Herba Hedyotidis Diffusae 18g
Take by weighing Radix Bupleuri, Rhizoma Pinelliae, Caulis Perillae and Herba Hedyotidis Diffusae, decoct with water secondary, add 10 times of amounts of water for the first time, decocted 3 hours, and added 8 times of amounts of water for the second time, decocted 2 hours, merge extractive liquid, filters, and it is 1.15~1.18 that the filtrate heating is concentrated into relative density, adding ethanol is 60% to containing the alcohol amount, and cold preservation was left standstill 24 hours, filtered, decompression filtrate recycling ethanol is not distinguished the flavor of to there being alcohol, and continues to be concentrated into thick paste, drying, pulverize, add binding agent and make granule, the hard capsule of packing into.
Embodiment 5: the preparation of medicament composition granule agent of the present invention
Radix Bupleuri 9g Rhizoma Pinelliae 12g Caulis Perillae 9g Herba Hedyotidis Diffusae 20g
Take by weighing Radix Bupleuri, Rhizoma Pinelliae, Caulis Perillae and Herba Hedyotidis Diffusae, decoct with water secondary, add 10 times of amounts of water for the first time, decocted 3 hours, and added 8 times of amounts of water for the second time, decocted 2 hours, merge extractive liquid, filters, and it is 1.15~1.18 that the filtrate heating is concentrated into relative density, adding ethanol is 60% to containing the alcohol amount, and cold preservation was left standstill 24 hours, filtered, decompression filtrate recycling ethanol is not distinguished the flavor of to there being alcohol, and continues to be concentrated into thick paste, drying, pulverize, adding Icing Sugar, binding agent are made granule.
Embodiment 6: the preparation of medicament composition granule agent of the present invention
Radix Bupleuri 9g Rhizoma Pinelliae 12g Caulis Perillae 9g
Take by weighing Radix Bupleuri, Rhizoma Pinelliae and Caulis Perillae, decoct with water secondary, add 10 times of amounts of water for the first time, decocted 3 hours, and added 8 times of amounts of water for the second time, decocted 2 hours, merge extractive liquid, filters, and it is 1.15~1.18 that the filtrate heating is concentrated into relative density, adding ethanol is 60% to containing the alcohol amount, and cold preservation was left standstill 24 hours, filtered, decompression filtrate recycling ethanol is not distinguished the flavor of to there being alcohol, and continues to be concentrated into thick paste, drying, pulverize, adding Icing Sugar, binding agent are made granule.
Embodiment 7: the preparation of medicinal composition soft capsule of the present invention
Radix Bupleuri 12g Rhizoma Pinelliae 15g Caulis Perillae 12g
Take by weighing Radix Bupleuri, Rhizoma Pinelliae and Caulis Perillae, decoct with water secondary, add 10 times of amounts of water for the first time, decocted 3 hours, and added 8 times of amounts of water for the second time, decocted 2 hours, merge extractive liquid,, filter, it is 1.15~1.18 that the filtrate heating is concentrated into relative density, and adding ethanol is 60% to containing the alcohol amount, cold preservation was left standstill 24 hours, filter, decompression filtrate recycling ethanol is not distinguished the flavor of to there being alcohol, and continues to be concentrated into thick paste, dry, pulverize, medicated powder, with soybean oil and soybean phospholipid, Cera Flava heating and melting, mixing, put coldly, add medicated powder, be pressed into soft capsule.
Embodiment 8: the preparation of medicinal composition soft capsule of the present invention
Radix Bupleuri 7g Rhizoma Pinelliae 10g Caulis Perillae 7g
Take by weighing Radix Bupleuri, Rhizoma Pinelliae and Caulis Perillae, decoct with water secondary, add 10 times of amounts of water for the first time, decocted 3 hours, and added 8 times of amounts of water for the second time, decocted 2 hours, merge extractive liquid,, filter, it is 1.15~1.18 that the filtrate heating is concentrated into relative density, and adding ethanol is 60% to containing the alcohol amount, cold preservation was left standstill 24 hours, filter, decompression filtrate recycling ethanol is not distinguished the flavor of to there being alcohol, and continues to be concentrated into thick paste, dry, pulverize, medicated powder, with soybean oil and soybean phospholipid, Cera Flava heating and melting, mixing, put coldly, add medicated powder, be pressed into soft capsule.
Embodiment 9: the preparation of medicament composition dropping pills of the present invention
Radix Bupleuri 11g Rhizoma Pinelliae 8g Caulis Perillae 10g
Take by weighing Radix Bupleuri, Rhizoma Pinelliae and Caulis Perillae decoct with water secondary, add 10 times of amounts of water for the first time, decocted 3 hours, and added 8 times of amounts of water for the second time, decocted 2 hours, merge extractive liquid,, filter, it is 1.15~1.18 that the filtrate heating is concentrated into relative density, and adding ethanol is 60% to containing the alcohol amount, cold preservation was left standstill 24 hours, filter, decompression filtrate recycling ethanol is not distinguished the flavor of to there being alcohol, and continues to be concentrated into thick paste, dry, pulverize, get medicated powder, polyethylene glycol 6000 heating and melting in water-bath, treat to add medicated powder after whole fusions, stirring and dissolving, 60 mesh sieves are filtered, and keep 60 ℃ to splash in the liquid paraffin that is chilled to below 10 ℃ and make ball.
Embodiment 10: the preparation of medicament composition dropping pills of the present invention
Radix Bupleuri 8g Rhizoma Pinelliae 12g Caulis Perillae 11g
Take by weighing Radix Bupleuri, Rhizoma Pinelliae and Caulis Perillae decoct with water secondary, add 10 times of amounts of water for the first time, decocted 3 hours, and added 8 times of amounts of water for the second time, decocted 2 hours, merge extractive liquid,, filter, it is 1.15~1.18 that the filtrate heating is concentrated into relative density, and adding ethanol is 60% to containing the alcohol amount, cold preservation was left standstill 24 hours, filter, decompression filtrate recycling ethanol is not distinguished the flavor of to there being alcohol, and continues to be concentrated into thick paste, dry, pulverize, get medicated powder, polyethylene glycol 6000 heating and melting in water-bath, treat to add medicated powder after whole fusions, stirring and dissolving, 60 mesh sieves are filtered, and keep 60 ℃ to splash in the liquid paraffin that is chilled to below 10 ℃ and make ball.