CN108524646B - Composition with bowel relaxing function and preparation method and application thereof - Google Patents
Composition with bowel relaxing function and preparation method and application thereof Download PDFInfo
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- CN108524646B CN108524646B CN201810723303.4A CN201810723303A CN108524646B CN 108524646 B CN108524646 B CN 108524646B CN 201810723303 A CN201810723303 A CN 201810723303A CN 108524646 B CN108524646 B CN 108524646B
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/752—Citrus, e.g. lime, orange or lemon
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/10—Laxatives
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Abstract
The invention belongs to the field of food, and discloses a composition with a function of relaxing bowel, which is prepared from the following raw materials in parts by weight: 1-20 parts of cistanche, 1-15 parts of poria cocos, 1-10 parts of fructus cannabis, 1-10 parts of bunge cherry seed, 1-10 parts of peach kernel, 1-10 parts of momordica grosvenori and 1-5 parts of dried orange peel. The composition has reasonable and unique formula, has the functions of tonifying spleen and kidney, promoting the production of body fluid and moistening dryness, ensures that the body fluid of middle-aged and old people is recovered, the intestinal tract is moistened, the lung qi and the stomach qi are communicated and descend, the body fluid and the qi of viscera are both adjusted, and the excrement is smooth, can be used for preparing health-care food with the function of improving the habitual constipation of the middle-aged and old people caused by the deficiency of the body fluid, the intestinal dryness and the deficiency of the spleen and the kidney, and has the advantages of safety, no side effect and.
Description
Technical Field
The invention belongs to the field of food, and relates to a health-care food composition with a function of relaxing bowel, and a preparation method and application thereof.
Background
In the modern society, the work and life pressure is high due to intense competition, the defecation habits are changed due to environmental and psychological factors (mental stress) and irregular diet, constipation crowds are increased rapidly due to great changes of diet structures (mainly meat and excessively fine food intake) after the living standard is improved, the constipation incidence rate is in a remarkable rising trend, and the life quality of people is seriously influenced.
Constipation is a common clinical digestive tract disease, and refers to a disease with constipation, prolonged defecation time, or difficulty and difficulty in defecation. The incidence rate of constipation is positively correlated with the age, and data reports that the incidence rate of constipation in China is 10% -15%, wherein the incidence rate is 3% for young people, 8% for middle-aged people and 20% for old people. The middle-aged and the elderly people are aged, the food intake and physical activity are obviously reduced, the gastrointestinal tract secretes digestive juice, the tension and the peristalsis of intestinal tubes are weakened, abdominal cavity and pelvic floor muscles are weak, internal and external sphincter of anus are weakened, the reflection of stomach and colon is weakened, the rectal sensitivity is reduced, so that food is retained in the intestines for a long time, and the excessive absorption of water causes constipation; the elderly are also fond of eating low-residue and fine food due to tooth loss, or they are convenient and trouble-saving, and have the disadvantages of simple diet and lack of coarse fiber, which causes the volume of feces to be reduced, the viscosity to be increased, the movement in the intestine to be slowed, and excessive water absorption to cause constipation. The middle-aged and the elderly suffer from common constipation which is easy to neglect due to the retrogressive change of physiological functions, so severe consequences such as angina, myocardial infarction, stroke and the like are often induced, and adverse effects are brought to families and society.
Modern medicine treats constipation, western medicine catharsis, enema and other methods are usually adopted in western medicine, and the treatment is temporary and permanent; the traditional Chinese medicine regulates the balance of yin, yang and viscera of the organism by treatment based on syndrome differentiation, fundamentally removes the pathogenic factors and fundamentally improves the physique of patients. The traditional Chinese medicine for treating constipation mainly comprises anthraquinone-containing irritant cathartics such as rheum officinale, senna leaves, aloe and semen cassiae, the medicines generally have quick response but large side effects, and can easily cause degeneration of intestinal muscle nerve plexus after long-term use to cause secondary constipation, damage qi and blood and body fluid, further cause more loss of original insufficient qi and blood and body fluid of middle-aged and elderly people, and easily cause dehydration and shock and even endanger life.
At present, traditional Chinese medicine health food with oriental medicine culture connotation and traditional diet characteristics is generally accepted and welcomed by people, and the health care function is to adjust the physiological function of the traditional Chinese medicine health food on the premise of maintaining and improving the body health. Therefore, the health-care food composition has the effects of tonifying spleen and kidney, promoting the production of body fluid and moistening dryness, and is of great significance for treating habitual constipation of middle-aged and elderly people.
Disclosure of Invention
In view of the above, the present invention aims to provide a health food composition capable of significantly improving habitual constipation of middle-aged and elderly people due to fluid deficiency and intestinal dryness and spleen and kidney deficiency, and a preparation method thereof.
The purpose of the invention is realized by the following technical scheme:
a composition with a function of relaxing bowel comprises the following components in parts by weight:
1-20 parts of cistanche; 1-15 parts of poria cocos; 1-10 parts of fructus cannabis; 1-10 parts of bunge cherry seeds; 1-10 parts of peach kernels; 1-10 parts of momordica grosvenori; 1-5 parts of dried orange peel.
Preferably, the composition with the function of relaxing bowel comprises the following components in parts by weight:
3-18 parts of cistanche; 2-12 parts of poria cocos; 1.5-8 parts of fructus cannabis; 1.5-8 parts of bunge cherry seeds; 1.5-8 parts of peach kernels; 1.5-8 parts of momordica grosvenori; 1.5-4 parts of dried orange peel.
Further preferably, the composition with the function of relaxing bowel comprises the following components in parts by weight:
5-18 parts of cistanche; 3-12 parts of poria cocos; 2-8 parts of fructus cannabis; 2-8 parts of bunge cherry seeds; 2-8 parts of peach kernels; 2-8 parts of momordica grosvenori; and 2-4 parts of dried orange peel.
Most preferably, the composition of the invention comprises the following components in parts by weight: 8-18 parts of cistanche; 8-12 parts of poria cocos; 3-8 parts of fructus cannabis; 3-8 parts of bunge cherry seeds; 3-8 parts of peach kernels; 3-8 parts of momordica grosvenori; 2.5-4 parts of dried orange peel.
Specifically, the composition comprises the following components in parts by weight: 18 parts of cistanche; 12 parts of poria cocos; 8 parts of fructus cannabis; 8 parts of bunge cherry seeds; 8 parts of peach kernel; 8 parts of momordica grosvenori; 4 parts of dried orange peel or 15 parts of cistanche deserticola; 10 parts of poria cocos; 6 parts of fructus cannabis; 6 parts of bunge cherry seeds; 6 parts of peach kernel; 6 parts of momordica grosvenori; 3 parts of dried orange peel or 10 parts of cistanche deserticola; 8 parts of poria cocos; 5 parts of fructus cannabis; 5 parts of bunge cherry seeds; 5 parts of peach kernel; 5 parts of momordica grosvenori; and 3 parts of dried orange peel.
The invention also provides a preparation method of the composition with the function of relaxing bowel, which comprises the following steps: weighing the components according to the formula ratio, and mixing to obtain the composition. The invention has no special requirement on the mixing mode of the raw materials, and the mixing method known in the field can be adopted, and the mixing mode is preferably as follows: mixing the above materials, grinding into powder or mixing the above materials, and steaming. Specifically, the mixed grinding mode is as follows: the components are mixed and then crushed into coarse powder, and then the coarse powder is crushed into superfine powder by a superfine crusher; wherein the particle size of the coarse powder is 40-60 meshes; the particle size of the superfine powder is more than 200 meshes.
The composition provided by the invention has the functions of tonifying spleen and kidney, promoting the production of body fluid and moistening dryness, so that the body fluid of the middle-aged and the elderly people is recovered, the intestinal tract is moistened, lung qi and stomach qi descend downwards, the body fluid and qi of viscera are regulated, and the stool is smooth. Clinical researches show that the components of the traditional Chinese medicine composition are reasonable in compatibility, can better treat the habitual constipation symptom of heat accumulation of the middle-aged and the elderly, and has an obvious constipation relieving effect. Therefore, another object of the present invention is to provide the use of the composition of the present invention in the preparation of health food with the function of relaxing bowel, especially in the preparation of health food with the function of improving constipation of the middle-aged and the elderly people.
The invention also aims to provide a health food prepared by taking the composition as an active ingredient or a main active ingredient and food acceptable additives.
The health food is biscuit, instant powder or tablet candy.
The additive is selected from maltodextrin, low-gluten flour, granulated sugar, butter, egg liquid, milk powder, sodium bicarbonate, salt, xylitol, milk powder, microcrystalline cellulose, xanthan gum, strawberry fruit powder, stevioside and magnesium stearate.
The raw materials of the biscuit comprise the composition with the function of relaxing bowel, maltodextrin, low-gluten flour, fine granulated sugar, butter, egg liquid, milk powder, baking soda and salt; wherein the dosages of the maltodextrin, the low-gluten flour, the granulated sugar, the butter, the egg liquid, the milk powder, the baking soda and the salt are respectively 20-25%, 15-20%, 20-25%, 12-18%, 1-2% and 1-1.5% of the weight of the composition with the function of relaxing bowel.
The biscuit is prepared according to the following steps:
(1) and raw material pretreatment: respectively taking herba cistanches, Poria, fructus Cannabis, semen Pruni, semen Persicae, fructus Siraitiae Grosvenorii, and pericarpium Citri Tangerinae, removing impurities, cleaning, and oven drying at 50-80 deg.C; mixing the dried raw materials according to the proportion, and firstly crushing the mixture into coarse powder; pulverizing into superfine powder by superfine pulverizer; wherein the granularity of the coarse powder is 40-60 meshes; the granularity of the superfine powder is more than 200 meshes;
(2) and blending: firstly, whipping butter, adding granulated sugar, continuously adding egg liquid, whipping, adding the superfine powder, maltodextrin, low-gluten flour, milk powder, baking soda and salt which are fully and uniformly mixed according to the proportion;
(3) kneading dough and molding: mixing the above materials, kneading into dough, standing for half an hour, uniformly partitioning, and tabletting;
(4) and baking: baking the formed biscuit at the temperature of 160-200 ℃ for 10-20min to obtain the biscuit.
The raw materials of the instant powder comprise the composition with the function of relaxing bowel, brown rice, maltodextrin, xylitol, milk powder, microcrystalline cellulose and xanthan gum; wherein the dosage of the brown rice, the maltodextrin, the xylitol, the milk powder, the microcrystalline cellulose and the xanthan gum is respectively 25-30%, 12-20%, 4-8% and 1-2% of the weight of the composition with the function of relaxing bowel.
The instant brewing powder is prepared according to the following steps:
(1) and raw material pretreatment: respectively taking herba cistanches, Poria, fructus Cannabis, semen Pruni, semen Persicae, fructus Siraitiae Grosvenorii, and pericarpium Citri Tangerinae, removing impurities, cleaning, and oven drying at 50-80 deg.C; removing impurities from brown rice, cleaning, air drying, parching, and aging to obtain parched brown rice;
(2) mixing and crushing: mixing the pretreated cistanche, poria cocos, fructus cannabis, bunge cherry seed, peach kernel, momordica grosvenori and dried orange peel with the fried brown rice according to the proportion, and firstly crushing the mixture into coarse powder; mixing with maltodextrin, xylitol, milk powder, microcrystalline cellulose and xanthan gum, and micronizing to obtain micropowder; wherein the granularity of the coarse powder is 40-60 meshes; the granularity of the superfine powder is more than 200 meshes.
The raw materials of the tablet candy comprise the composition with the function of relaxing bowel, maltodextrin, strawberry fruit powder, microcrystalline cellulose, stevioside and magnesium stearate; the composition comprises maltodextrin, strawberry fruit powder, microcrystalline cellulose, stevioside and magnesium stearate, wherein the dosage of the maltodextrin, the strawberry fruit powder, the microcrystalline cellulose, the stevioside and the magnesium stearate is 16-22%, 22-32%, 28-35%, 1-2% and 3.5-5% of the weight of the composition with the function of relaxing bowel.
The tablet candy is prepared according to the following steps:
(1) and raw material pretreatment: respectively taking herba cistanches, Poria, fructus Cannabis, semen Pruni, semen Persicae, fructus Siraitiae Grosvenorii, and pericarpium Citri Tangerinae, removing impurities, cleaning, and oven drying at 50-80 deg.C; mixing the dried raw materials according to the proportion, and firstly crushing the mixture into coarse powder; pulverizing into superfine powder by superfine pulverizer; wherein the granularity of the coarse powder is 40-60 meshes; the granularity of the superfine powder is more than 200 meshes;
(2) granulating and tabletting: weighing the superfine powder, maltodextrin, strawberry fruit powder, microcrystalline cellulose and stevioside according to the proportion, fully and uniformly mixing, and preparing a whole granule through granulation, drying and granule finishing; adding magnesium stearate, mixing, and tabletting with proper punch die to obtain tablet candy; wherein, the granulating mode is preferably wet granulating.
Cistanchis herba has sweet taste, salty and warm property, and no toxicity, and enters kidney and large intestine meridians. It is a top-grade herb for tonifying kidney, replenishing essence, moistening intestines and relaxing bowels, so it is called "leisurely" because it is not drastic and mild in purgation, and is a traditional herb for treating old people, deficiency of blood, deficiency of body fluids, deficiency of kidney and constipation. The book materia medica Zhengyi (year): cistanche deserticola has a salty taste which can be reduced, moisten and dredge intestines to dominate the uncomfortable defecation and obtain a shortcut, and has warm and moist nature, and can nourish yin and dredge yang, so that the cistanche deserticola can dredge the viscera without damaging body fluid, especially the ears. The empirical formula is usually prepared from cistanche, and the decoction or the tea for drinking has good effect on treating constipation of old people. Pharmacological research shows that inorganic salts and colloidal polysaccharide contained in the cistanche deserticola can effectively reduce defecation time, increase intestinal peristalsis times and time, obviously prevent water from being absorbed by the large intestine and play a role in relaxing the bowels.
Poria cocos, with sweet and bland taste and neutral nature, enters heart, lung, spleen and kidney meridians. Has the functions of invigorating spleen, calming heart, promoting diuresis and eliminating dampness; the medical records in the treatise on the property of medicine have the functions of appetizing, relieving convulsion and soothing the nerves. Poria has effects in invigorating spleen, regulating stomach function, strengthening intestine, removing blood stasis, promoting diuresis, strengthening body resistance, eliminating pathogenic factors, tonifying body without beauty, and benefiting without fierce. Evaluation of compendium of materia Medica: poria cocos benefits spleen and stomach, excreting dampness and inducing diuresis, has a light and weak flavor and flavor, and its property ascends, produces body fluid, opens striae, nourishes water and reduces urination, so it belongs to yang, floats and ascends, and its property is also. The "seepage" of tuckahoe is similar to the function of spleen qi to ascend and clear, and is helpful for the spleen to absorb nutrients. The tuckahoe promotes urination, thereby discharging moisture in intestines and stomach, and playing the roles of strengthening spleen qi and smoothing defecation. This is in line with the Chinese traditional theory of inducing diuresis with defecation.
Fructus cannabis is sweet in taste and neutral in nature, has the functions of entering spleen, stomach and large intestine channels, has the functions of relaxing bowel, nourishing and tonifying deficiency, and is particularly suitable for the old, the lying-in woman and the constipation caused by intestinal dryness due to the deficiency of body fluid and blood. The records of the "pharmacy and medical records" are: ma ren can moisten intestine, moisten body and remove dryness, so it is indicated for constipation due to qi stagnation in large intestine. Pharmacological research shows that the fructus cannabis contains a large amount of fatty oil components, and plays a role in lubricating the intestinal tract; the fructus Cannabis extract can stimulate intestinal tract, activate intestinal tract secretion function, and increase intestinal tract peristalsis amplitude, so fructus Cannabis has effects of loosening bowel to relieve constipation.
Semen Pruni has pungent, bitter, sweet and neutral nature, and has effects of moistening and increasing fat, moistening intestine and relaxing bowels, and moistening middle-jiao and qi of large intestine, and can be used for treating fluid deficiency, intestinal dryness, constipation, flatulence, qi stagnation, food stagnation, edema of limbs, and dyschezia. The record of the prescription records that it is specially used for treating qi stagnation and dryness and unsmooth circulation of large intestine. It is recorded in Ben Cao Jing Shu that it is specialized in descending, directing the accumulation of large intestine dryness and benefiting the whole body of water and qi. Pharmacological research shows that the bunge cherry seeds contain bunge cherry seed glycosides, fatty oil, volatile organic acid, saponin, phytosterol and other components, can effectively promote gastrointestinal motility, lubricate intestinal tracts, accelerate excretion of feces in the intestinal tracts and play a role in relaxing bowels and purgation.
Peach kernel, semen Persicae is bitter and sweet in taste and neutral in nature, enters heart, liver and large intestine channels, and has the effects of promoting blood circulation, removing blood stasis, moistening intestine and relaxing bowels. The book Ben Cao Yan Yi Bu Yi (supplement to the Yi) cites the cloud from Heart: peach kernel, semen Persicae has the effect of eliminating the hard lumps in blood and regulating menstruation, and is a deficient secret for the elderly. Tao ren is good at treating constipation due to intestinal dryness due to fluid deficiency, constipation due to blood deficiency, and constipation due to deficiency of the elderly. Peach kernel, semen Persicae is bitter in taste and can purge blood stasis, sweet, slow and moist and moisten intestine dryness, when treating habitual constipation, even if there is no obvious symptom of blood stasis, peach kernel is added properly based on syndrome differentiation treatment according to the theory of 'blood impairment into collaterals by long-term illness' to dissipate blood stasis and smooth qi movement, so that constipation can be removed. Pharmacological research shows that: peach kernel contains 45% of fatty oil, can improve the lubricity of intestinal content mucous membrane, and has the effects of improving blood flow blockage, blood circulation disorder and the like.
Siraitia grosvenorii is sweet in taste and cool in nature, and enters lung and large intestine meridians. Has the functions of moistening lung and relaxing bowels, dispersing lung qi, and moistening, and can promote the production of body fluid, moisten intestines and relax bowels, and treat constipation due to intestinal dryness. Pharmacological research shows that: the mogroside can promote the intestinal peristalsis of mice, remarkably reduce the ink propulsion rate of the mice with water-deprivation and dryness-accumulation type constipation, reduce the first defecation time and increase the defecation quantity and quality; the purgative action of the medicine is much more moderate than that of the laxative traditional Chinese medicines such as senna leaf, so the medicine is more suitable for treating the constipation of the old or the weak.
The dried orange peel is bitter and pungent in flavor and warm in nature, and enters spleen, stomach and lung meridians; the product has effects of dispersing qi, regulating qi-flowing, eliminating dampness and phlegm, inducing diuresis and relaxing bowels, and can be used for treating incoordination between spleen and stomach, abdominal pain, phlegm dampness obstructing lung, cough with excessive phlegm, dysuresia, and constipation. "Dachangchi Dachang Mi sai" recorded in Ben Cao gang mu (compendium of materia Medica) for treating pericarpium Citri Tangerinae; the ancient prescription containing dried orange peel can be used for treating constipation, which indicates that dried orange peel has the function of relaxing bowels. Pharmacological research shows that: the small dose of tangerine peel has no obvious influence on the intestinal propulsion movement of the mouse, and the large dose of tangerine peel can obviously accelerate the intestinal propulsion movement of the mouse; it is the main mechanism of the purgation action of dried orange peel to increase the intestinal contraction and promote the intestinal propulsion. For various diseases, the bitter orange peel can purge energy and dry, and the pungent orange peel can disperse energy and harmonize, so that the effect of regulating qi and drying dampness is taken to cooperate with the tuckahoe to play the role of invigorating spleen and remove the source of qi, fluid and body fluid stagnation; it can be used with Tao ren to moisten the blood in large intestine.
Compared with the prior art, the invention has the beneficial effects that:
the composition consists of cistanche, tuckahoe, fructus cannabis, bunge cherry seed, peach kernel, fructus momordicae and dried orange peel with high safety, wherein the cistanche is a variety listed in the superior products of Shen nong herbal Jing, namely' the main life-nourishing is suitable for the day, has no toxicity, has high nutritional value and no toxic or side effect, and is widely eaten in folks; and the tuckahoe, the fructus cannabis, the bunge cherry seed, the peach kernel, the momordica grosvenori and the dried orange peel belong to homologous products of medicine and food. In the formula, the cistanche deserticola is a monarch drug, and has the effects of nourishing kidney and replenishing vital essence, and relaxing bowel; poria cocos, Poria; fructus cannabis, bunge cherry seed and peach kernel are used for moistening dryness and lubricating intestines, so that the effect of relaxing bowel is enhanced; fructus momordicae is used as an adjuvant drug for dispersing lung qi, promoting the production of body fluid and moistening the intestines, and pericarpium citri reticulatae is used for dispersing qi and activating stagnancy. The combination of all the herbs can warm kidney and invigorate spleen, promote the generation of body fluid, moisten large intestine, and relieve constipation.
The composition has safe and healthy formula, ensures the safety of the product from the raw material perspective, has the efficacy of food therapy and health care, is more suitable for the requirements of middle-aged and elderly people for regulating and improving the physiological function of the organism to relax the bowels, ensures that the body fluid of the middle-aged and elderly people recovers, the intestinal tract is moistened, the lung qi and the stomach qi are communicated and descend, the body fluid and the qi of viscera are both regulated, and the excrement is communicated.
Detailed Description
The following will clearly and completely describe the technical solutions of the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Example 1
The biscuit is prepared from the following raw materials and additives in parts by weight: 18 parts of cistanche; 12 parts of poria cocos; 8 parts of fructus cannabis; 8 parts of bunge cherry seeds; 8 parts of peach kernel; 8 parts of momordica grosvenori; 4 parts of dried orange peel; 16 parts of maltodextrin; 12 parts of low-gluten flour; 16 parts of fine granulated sugar; 16 parts of butter; 10 parts of egg liquid; 10 parts of milk powder; 1 part of baking soda; 0.8 part of common salt.
The preparation method specifically comprises the following steps:
(1) pretreatment of raw materials: respectively removing impurities from Cistanchis herba, Poria, fructus Cannabis, semen Pruni, semen Persicae, fructus Siraitiae Grosvenorii, and pericarpium Citri Tangerinae, cleaning, and oven drying at 50-80 deg.C; mixing the above dried materials at a certain ratio, pulverizing into coarse powder (about 40-60 mesh); pulverizing into superfine powder (above 200 meshes) by air-guiding superfine pulverizer;
(2) blending: firstly, whipping butter, adding granulated sugar, continuously adding egg liquid, whipping, and then adding the superfine powder, maltodextrin, low-gluten flour, milk powder, baking soda and salt which are fully and uniformly mixed according to the proportion;
(3) dough kneading and molding: mixing the above materials, kneading into dough, standing for half an hour, uniformly partitioning, and tabletting;
(4) baking: placing the formed cake blank into an oven, controlling the temperature of the surface fire and the bottom fire to be 160-200 ℃, and baking for 10-20min until the color meets the requirement; taking out, cooling, and packaging with air-extracting sealing machine to obtain cookies.
Example 2
The instant brewing powder is prepared from the following raw materials and additives in parts by weight: 15 parts of cistanche; 10 parts of poria cocos; 6 parts of fructus cannabis; 6 parts of bunge cherry seeds; 6 parts of peach kernel; 6 parts of momordica grosvenori; 3 parts of dried orange peel; 15 parts of brown rice; 15 parts of maltodextrin; 15 parts of xylitol; 8 parts of milk powder; 3 parts of microcrystalline cellulose; 0.6 part of xanthan gum.
The preparation method specifically comprises the following steps:
(1) pretreatment of raw materials: respectively removing impurities from Cistanchis herba, Poria, fructus Cannabis, semen Pruni, semen Persicae, fructus Siraitiae Grosvenorii and pericarpium Citri Tangerinae, cleaning, and oven drying at 50-80 deg.C; removing impurities from brown rice, cleaning, air drying, parching, and aging to obtain parched brown rice;
(2) crushing and mixing: mixing pretreated Cistanchis herba, Poria, fructus Cannabis, semen Pruni, semen Persicae, fructus Siraitiae Grosvenorii, pericarpium Citri Tangerinae and parched brown rice at a certain proportion, and pulverizing into coarse powder (about 40-60 mesh); mixing with maltodextrin, xylitol, milk powder, microcrystalline cellulose and xanthan gum at a certain ratio, and pulverizing into superfine powder (above 200 meshes) by air-introduced superfine pulverizer to obtain instant granule;
(3) packaging: and packaging the prepared instant brewing powder.
Example 3
The tablet candy is prepared from the following raw materials and additives in parts by weight: 10 parts of cistanche; 8 parts of poria cocos; 5 parts of fructus cannabis; 5 parts of bunge cherry seeds; 5 parts of peach kernel; 5 parts of momordica grosvenori; 3 parts of dried orange peel; 8 parts of maltodextrin; 10 parts of strawberry fruit powder; 12 parts of microcrystalline cellulose; 0.5 part of stevioside; and 1.5 parts of magnesium stearate.
The preparation method specifically comprises the following steps:
(1) pretreatment of raw materials: before use, respectively removing impurities from Cistanchis herba, Poria, fructus Cannabis, semen Pruni, semen Persicae, fructus Siraitiae Grosvenorii and pericarpium Citri Tangerinae, cleaning, oven drying at 50-80 deg.C, and pulverizing into coarse powder (about 40-60 mesh); pulverizing into superfine powder (above 200 meshes) by air-guiding superfine pulverizer;
(2) granulating, drying and finishing: weighing superfine powder, maltodextrin, strawberry fruit powder, microcrystalline cellulose and stevioside according to the proportion, and fully and uniformly mixing; adding 80% (volume fraction) ethanol as wetting agent, and performing wet granulation; drying in a blast drying oven at 60 +/-5 ℃; drying, sieving and granulating;
(3) tabletting and packaging: adding magnesium stearate as release agent into the whole granule, mixing, pressing into proper tablet shape, and packaging to obtain tablet candy.
Comparative example 1
The additive is prepared from the following raw materials in parts by weight: 10 parts of cistanche; 8 parts of poria cocos; 5 parts of fructus cannabis; 5 parts of bunge cherry seeds; 3 parts of dried orange peel; 8 parts of maltodextrin; 10 parts of strawberry fruit powder; 12 parts of microcrystalline cellulose; 0.5 part of stevioside; and 1.5 parts of magnesium stearate. A tabletted candy was prepared according to the method of example 3.
Comparative example 2
The additive is prepared from the following raw materials in parts by weight: 10 parts of cistanche; 8 parts of poria cocos; 5 parts of fructus cannabis; 5 parts of bunge cherry seeds; 5 parts of peach kernel; 3 parts of dried orange peel; 8 parts of maltodextrin; 10 parts of strawberry fruit powder; 12 parts of microcrystalline cellulose; 0.5 part of stevioside; and 1.5 parts of magnesium stearate. A tabletted candy was prepared according to the method of example 3.
Comparative example 3
The additive is prepared from the following raw materials in parts by weight: 10 parts of cistanche; 8 parts of poria cocos; 5 parts of fructus cannabis; 5 parts of bunge cherry seeds; 5 parts of momordica grosvenori; 3 parts of dried orange peel; 8 parts of maltodextrin; 10 parts of strawberry fruit powder; 12 parts of microcrystalline cellulose; 0.5 part of stevioside; and 1.5 parts of magnesium stearate. A tabletted candy was prepared according to the method of example 3.
Comparative example 4
The additive is prepared from the following raw materials in parts by weight: 10 parts of cistanche; 5 parts of fructus cannabis; 5 parts of bunge cherry seeds; 5 parts of peach kernel; 5 parts of momordica grosvenori; 3 parts of dried orange peel; 8 parts of maltodextrin; 10 parts of strawberry fruit powder; 12 parts of microcrystalline cellulose; 0.5 part of stevioside; and 1.5 parts of magnesium stearate. A tabletted candy was prepared according to the method of example 3.
Example 4 clinical Observation experiments
The test example is from the following sources: 210 middle-aged and elderly constipation patients (from outpatient service in department of gastroenterology in cooperative hospital) with age of 45-70 years and similar constipation symptoms (habitual constipation due to intestinal dryness and heat accumulation) were randomly divided into seven groups (seven groups have no statistical significance for sex and age difference, P >0.05), and 30 patients in each group were administered the products of example 1, example 2, example 3, comparative example 1, comparative example 2, comparative example 3 and comparative example 4.
The experimental method comprises the following steps: the products of the examples are taken according to the regulations in each case: the preparation is administered 2 times daily, 12.5 g/time, 4 weeks as a cycle, and 3 cycles in total. The improvement condition of constipation is observed before and after administration, the grading quantitative score of constipation is recorded, and the curative effect index is calculated according to the obtained score to evaluate the curative effect.
The Chinese medicine symptom quantification indexes of constipation are as follows: dry stool, time interval between defecations, hard defecation, dry mouth, little saliva, hectic fever, night sweat, vexation, little sleep and the like. The scoring standards are defined in Table 1 according to the guidelines of clinical research on new Chinese medicine.
TABLE 1 Constipation symptom grading and quantitative scoring sheet
The evaluation standard of curative effect is as follows: the curative effect index is (integral before taking-integral after taking)/integral before taking x 100%
And (3) curing: after taking, defecation is completely normal or returns to the previous level, and other symptoms completely disappear (the curative effect index is more than or equal to 90 percent);
the effect is shown: after the composition is taken, defecation is obviously improved, the defecation interval time is normal, and the defecation property is close to normal (the curative effect index is more than or equal to 70 percent and less than 90 percent);
the method has the following advantages: after the composition is taken, the dry stool is better, and other symptoms are better (the curative effect index is more than or equal to 30 percent and less than 70 percent);
and (4) invalidation: after the medicine is taken, defecation is not improved, and other symptoms are not improved (the curative effect index is less than 30%).
And (3) evaluating the curative effect: according to the therapeutic index analysis, the formula is shown in Table 2.
TABLE 2 therapeutic effect of examples and comparative examples
After the composition is taken, the subjects have no toxic or side effect, and the composition is safe and has no side effect. The total effective rates of the examples 1, 2 and 3 are respectively 86.7%, 90.0% and 93.3%, and the ratio of X is determined between the groups of the examples2The test is as follows: x2＝0.195(<7.81)、P>0.05，X2＝1.001(<7.81)、P>0.05，X2＝0.382(<7.81)、P>0.05, which shows that the constipation of each example group is obviously improved, and the groups have no obvious difference. The total effective rates of comparative examples 1, 2, 3 and 4 were 53.3%, 70.0%, 66.7% and 60.0%, respectively, which shows that the constipation of each comparative example is improved. Example 1 and comparative examples 1, 2, 3 and 4, respectively, were measured by X2And (4) checking, namely: x2＝14.28(>11.34)、P<0.01，X2＝8.39(>7.81)、P<0.05，X2＝9.82(>7.81)、P<0.05，X2＝12.17(>11.34)、P<0.01, and therefore, the examples have significant difference compared with the comparative example, namely, the curative effect of each example is significantly better than that of the comparative example. In the embodiment, the components are matched with each other, so that the symptoms of dry stool, difficult defecation, dry mouth, little body fluid, hectic fever, night sweat and the like of the middle-aged and the elderly can be effectively relieved, the effects of tonifying spleen and kidney, promoting fluid production and moistening dryness, relaxing bowel and the like are achieved, and habitual constipation caused by body fluid deficiency, intestinal dryness and spleen and kidney deficiency of the middle-aged and the elderly is obviously improved.
The above description of the embodiments is only intended to facilitate the understanding of the method of the invention and its core idea. It should be noted that, for those skilled in the art, it is possible to make various improvements and modifications to the present invention without departing from the principle of the present invention, and those improvements and modifications also fall within the scope of the claims of the present invention.
Claims (7)
1. The composition with the function of relaxing bowel is characterized by comprising the following components in parts by weight: 10-18 parts of cistanche; 8-12 parts of poria cocos; 5-8 parts of fructus cannabis; 5-8 parts of bunge cherry seeds; 5-8 parts of peach kernels; 5-8 parts of momordica grosvenori; 2.5-4 parts of dried orange peel.
2. A method of preparing the composition of claim 1, comprising: weighing the components according to the formula ratio, and mixing to obtain the composition.
3. A method of preparing a composition according to claim 2, wherein said mixing is by: mixing the above materials, grinding into powder or mixing the above materials, and steaming.
4. Use of the composition of claim 1 for preparing a health food having a bowel relaxing function.
5. Use of the composition of claim 1 for preparing a health food having a function of improving constipation in middle and old aged people.
6. A health food characterized by being prepared from the composition of claim 1 as an active ingredient or a main active ingredient, and a food-acceptable additive.
7. The health food of claim 6, wherein the health food is a biscuit, a ready-to-eat instant powder or a tabletted candy.
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| Aqueous Extracts of Herba Cistanche Promoted Intestinal Motility in Loperamide-Induced Constipation Rats by Ameliorating the Interstitial Cells of Cajal;Shuai Yan等;《Evidence-Based Complementary and Alternative Medicine》;20171128;第1-13页 * |
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