CN1325086C - Bear gall eyesight-improving tablet - Google Patents

Abstract

The present invention relates to a bear gall tablet for improving eyesight, which belongs to the field of traditional Chinese medicine. The tablet is prepared from several kinds of Chinese herbal medicine comprising bear gall powder, sea-ear shell, chrysanthemum, calcined sea-ear shell, barbary wolfberry fruit, stir-frying water plantain, gentian and motherwort fruit by means of a traditional Chinese medicine preparation process. The tablet is a pure traditional Chinese medicine preparation and has the advantages of no toxic or side effect and obvious curative effect. A plurality of kinds of medicine are used together, and the tablet has the functions of clearing the liver heat, eliminating heat, nourishing yin and improving eyesight. The tablet has obvious curative effects on contracted pupils, green-blue wind internal obstruction caused by depressed liver-gallbladder heat, conjunctival congestion and pain, aversion to light, tearing, blurred vision, vexation, agitation, irascibility, bitter mouth, dry pharynx, acute iridocyclitis, primary open-angle glaucoma, etc.

Description

The Chinese medicinal tablet of treatment ophthalmic diseases

Technical field

The present invention relates to the field of Chinese medicines, particularly a kind of Chinese medicinal tablet for the treatment of ophthalmic diseases.

Background technology

Order is one of face, and " the big fascination opinion of Ling Shu Miraculous Pivot or Divine Axis " say, " the essence of five ZANG-organs and six FU-organs gas is annotated on all in order and smart for it." official of order person liver, the vital organs of the human body, order is waited for it, the liver acting in the body resembling a general, and the kidney being the origin of congenital constitution, hides Kidney-Yin and residence Yuanyang.Deficiency of the liver and kindey is eyes losing nutrition then, and wind-heat of liver channel stop up to be contained, consume kidney essense and the disease of seeing order causes distending pain of the head and eyes, ciliary hyperemia, diseases such as order is secretly dim-sighted, intraocular pressure rising.Especially middle-aged and elderly people, with advancing age, each organ dysfunction of body is aging gradually, deficiency of both the liver and kidney and easily cause the order flower, visual deterioration, diseases such as glaucoma.Interior ophthalmic is ophthalmology common disease, frequently-occurring disease, and the Chinese medicine for the treatment of ophthalmic diseases at present is few, and the course of treatment of treatment long, take effect slowly, the effectively oral Chinese patent medicine of controlling ophthalmic is very few especially on the market.

Summary of the invention

The object of the present invention is to provide a kind of Chinese medicinal tablet for the treatment of ophthalmic diseases, the Chinese medicine that has solved existing treatment ophthalmic diseases is few, and the course of treatment of treatment is long, slow problem takes effect.

According to the theory of Chinese medical science and the clinical trial certificate of motherland,, has important function with the various interior ophthalmics of endo-medicine treatment.Therefore, the pure Chinese herbal medicine of the selected following all flavors of the present invention is made by traditional Chinese medicine processing technology.Its concrete prescription following (by ratio of weight and the number of copies):

200～560 parts of 1.5～8 parts of Concha Haliotidis of Fel Ursi powder

60～180 parts of 200～560 parts of Concha Haliotidis (calcined) of Flos Chrysanthemi

100～500 parts of 200～560 parts of Rhizoma Alismatis (processed) of Fructus Lycii

180～400 parts of 180～400 parts of Fructus Leonuris of Radix Gentianae

Optimum ratio of the present invention is (by ratio of weight and the number of copies):

360 parts of 4 parts of Concha Haliotidis of Fel Ursi powder

120 parts of 360 parts of Concha Haliotidis (calcined) of Flos Chrysanthemi

300 parts of 360 parts of Rhizoma Alismatis (processed) of Fructus Lycii

240 parts of 240 parts of Fructus Leonuris of Radix Gentianae

Medicine of the present invention can adopt the conventional method of Chinese medicine preparation to be prepared into any conventional oral formulations.The preferred processing procedure of the present invention is as follows:

More than eight the flavor medicines, Fel Ursi powder is ground into fine powder; Concha Haliotidis (calcined) is ground into fine powder; Radix Gentianae is collected percolate or extracting solution with 50%～95% ethanol percolation or reflux, extract,, reclaims ethanol, be concentrated into temperature in the time of 15 ℃～65 ℃, relative density is 1.15～1.45, and is standby; Get Concha Haliotidis and decoct after 30 minutes earlier, add all the other Flos Chrysanthemis, Fructus Lycii, Rhizoma Alismatis (processed), Fructus Leonuri four flavors, decoct with water three times, time was followed successively by 2 hours, 1 hour, 1 hour, and collecting decoction filters, filtrate be concentrated into temperature in the time of 15 ℃～65 ℃, relative density is 1.10～1.30, adds 2.5 times of amounts of ethanol, stir evenly, left standstill 24 hours, and filtered filtrate recycling ethanol, be concentrated into temperature in the time of 15 ℃～65 ℃, relative density is 1.15～1.45, merge with the Radix Gentianae fluid extract, drying is pulverized; Add Fel Ursi powder, Concha Haliotidis (calcined) fine powder and appropriate amount of starch, mixing is granulated, drying, and compacting is in blocks, and coating is promptly.

[character] this product is coated tablet or Film coated tablets, removes to show taupe behind the coating; Gas is raw meat slightly, bitter in the mouth.

The heavy 0.45g of [specification] substrate.

[function cures mainly] purging liver-heat, YIN nourishing makes eye bright.It is hot and suffocating to be used for liver and gall, iridocyclitis, bluish glaucoma due to the cloudy insufficiency of essence, and disease is seen conjunctival congestion and pain of eye, photophobia is shed tears, blurred vision, irritated irritability, bitter taste in the mouth and dry throat; Acute iridocyclitis, primary open angle glaucoma are seen above-mentioned patient.

[usage and dosage] is oral.One time 4,3 times on the one, or follow the doctor's advice.

Among the present invention:

Monarch drug in the first-selected Fel Ursi side of being, the Fel Ursi merit is arrogated to oneself heat-clearing and toxic substances removing, and improving acuity of vision and removing nebula is brought down a fever and can be cleared away heart-fire, and suppressing the hyperactive liver materials for improving vision removing nebula is the medicine of TCM Ophthalmology treatment cataract and external oculopathy oculopathy.

Ministerial drug Concha Haliotidis suppressing the hyperactive liver and subsiding YANG, the barrier that disappears makes eye bright; Can removing heat from the liver, go that stagnated fire, dissipating blood stasis stagnate, block removing film, tonifying liver the moon, nourishing the liver blood.

The Flos Chrysanthemi dispelling wind and heat pathogens again can tonifying YIN, removing heat in the liver for improving eyesight, detoxifcation, but the removing nebula film make eye bright, advocate catharsis and reach in the top, mountain peak, receive and take the photograph empty sun and belong to Liver and kidney; The energy clearing away liver-fire, breath endogenous wind, but the perverse and unreasonable manner of wood gas are taken the photograph on the empty sun floating; Be the ministerial drug among the we.

Fructus Lycii the kidney invigorating and essence nourishing, nourishing the liver to improve visual acuity; The profit and nourish, double can bringing down a fever and specially in the kidney invigorating, lung moistening, promote the production of body fluid, QI invigorating, be the key medicine of the tired interior-heat tonification of Liver and kidney kidney-YIN being deficient.Three's 5 usefulness, auxilliary monarch drug can increase the merit of liver heat removing and eyesight improving, and not only the fire of wind heat can be clear, and the void of Liver and kidney can be mended, and makes overall plans, and brings out the best in each other.Be the ministerial drug among the we.

Rhizoma Alismatis lets out fire mutually, hearing-improing and eyesight improving clearly.A surname logical damp and hot, let out mutually fire, fidelity is cloudy, for the sharp clear product of holding concurrently, is the adjuvant drug among the we.

Radix Gentianae eliminating pathogen in the liver gallbladder fire, clearing heat and expelling damp.Can lead the three warmers stagnated fire off, assistant helps clearly then cold coagulation not of ministerial drug, has fosterly in dredging, and is the adjuvant drug among the we.

The Fructus Leonuri blood circulation promoting and blood stasis dispelling, reducing swelling and alleviating pain.Mend and can manage it, hot diffusing and profit person also, use make for drawing that dredging the meridian blood prosperous without obstacle is capable, order gets blood and moistens foster, vision Clear and Bright naturally then.

Good effect of the present invention is: medicine is a pure Chinese medicinal preparation, has no side effect, and is evident in efficacy, and all medicines share, and have purging liver-heat, the effect that YIN nourishing makes eye bright.Hot and suffocating to liver and gall, iridocyclitis, bluish glaucoma due to the cloudy insufficiency of essence, disease is seen conjunctival congestion and pain of eye, photophobia is shed tears, blurred vision, fidgety irritability, bitter taste in the mouth and dry throat; The effect of disease treatment such as acute iridocyclitis, primary open angle glaucoma is remarkable.

Below by testing the beneficial effect of further setting forth medicine of the present invention:

One, experiment stock

Test drug bear gall eyesight-improving tablet 0.45g/ sheet, every contains crude drug amount 1.984g, is made into 2.16g crude drug/ml (Cmax) with distilled water during experiment.Provide by Jilin Changbaishan Pharmaceutical Group Co., Ltd..

Animal Kunming kind white mice, body weight are 18～24g, male and female half and half.Animal housing provides by the Jilin Prov. Inst. of Chinese Medicine and Chinese Medical Science, and animal quality is qualified.

Two, purpose

Observe the toxic reaction situation that 24h takes medicine of the present invention in a large number.

Three, method and result

Get 20 of Kunming kind white mice, fasting 12h can't help water.In 24h, irritate the stomach bear gall eyesight-improving tablet three times, each 0.4ml/10g body weight, accumulative total is irritated stomach maximum volume 1.2ml/10g, is equivalent to 269.20g crude drug/kg.Observed 7 after the administration, none routine Mus death, animal diet followed is normal, weight increase, the hair color light, activity is not seen other unusual performance freely.Because of administration volume, drug level all reach to greatest extent, so fail to measure LD50.Its oral administration maximum tolerated dose＞259.20g crude drug/kg is equivalent to 648 times of clinical application amount.Clinical application amount computational methods are 4 slices/time * 3 times * 1.984g crude drug/sheet ÷ 60kg=0.40g crude drug/kg.

Four, conclusion

The result shows, obeys bear gall eyesight-improving tablet in a large number and does not have acute toxic reaction.

Find that by acute toxicity test drug toxicity of the present invention is less, has done following experiment for proving its long term toxicity situation inventor.

One, experiment stock

Test drug bear gall eyesight-improving extractum does not add substrate.Provide by Jilin Changbaishan Pharmaceutical Group Co., Ltd., face the time spent to be made into 50% suspension.1 gram cream is equivalent to 2.7 gram crude drugs.

Animal Weistar rat, body weight are 80～100 grams, male and female half and half.Animal housing provides by the Jilin Prov. Inst. of Chinese Medicine and Chinese Medical Science, and animal quality is qualified.

Two, purpose

Find that by acute toxicity test drug toxicity of the present invention is less, has done following experiment for proving its long term toxicity situation inventor.

Three, method and result

Get 80 of above-mentioned animals, be divided into 4 groups at random, male and female half and half, one group is contrast, respectively presses 8g/kg, 4g/kg, 1g/kg for three groups in addition, is equivalent to 21.6g crude drug/kg, 10.8g crude drug/kg, 2.7g crude drug/kg is diluted to the volume gastric infusion, is equivalent to 64 times, 32 times, 8 times of clinical day dosage 0.34g of people crude drug/kilogram respectively.Irritate stomach every day once, totally 90 days.After last administration, collect urine in 24 hours, the back sacrificed by decapitation of weighing.Collect blood, survey routine blood test, routine urinalysis, hepatic and renal function, the results are shown in Table 1-3.Core simultaneously, liver, spleen, lung, kidney, adrenal gland do the pathology section.

The trimestral experimentation of rat, no abnormal reaction, the feces dry forming, ophthalmic does not have secretions, hair color gloss, body weight is normal, and the 7th day secondary of weighing in 1 month during beginning weighed once in back 2 months per 10 days.See table 1-3 for details.

From the experimental data statistical framework, bear gall eyesight-improving tablet toxic and side effects and matched group relatively do not have significant difference.

See also do not have discovery to have obviously unusually from the urine sample check result.

Four, conclusion

Medicine of the present invention does not make significant difference to the rat body weight, P value＞0.05, from the routine blood test routine urinalysis, the result can find out that also this poison of drug side effect is very little, indexs such as liver function, blood cell, platelet all belong to normal range, see also Non Apparent Abnormality of each internal organs from pathological section, so, this medicine has no side effect in 8g/kg dosage scope substantially.

Male white rat weight increase table (1)

Group	Natural law x+SD	10 days x ± SD	20 days x ± SD	30 days x ± SD	40 days x ± SD	50 days x ± SD	60 days x ± SD	70 days x ± SD	80 days x ± SD	90 days x ± SD	Weightening finish (g) x ± SD
												Matched group	97.65 ±4.60	158.00 ±21.1	208.87 ±20.25	241.10 ±10.78	261.22 ±19.86	289.14 ±17.17	298.90 ±19.56	321.77 ±18.66	321.77 ±18.66	346.17 ±18.30	248.0 ±18.99
Heavy dose of 8g/kg	102.00 ±5.43	164.33 ±12.33	216.12 ±18.05	248.69 ±17.10	281.96 ±20.06	309.12 ±19.24	319.69 20.91	334.40 ±21.61	343.12 ±24.17	389.68 ±22.16	287.69 ±21.45
												Middle dosage 4g/kg	97.45 ±5.57	159.90 ±11.61	205.55 ±18.00	241.11 ±18.26	279.80 ±24.90	297.76 ±18.21	319.21 ±17.61	328.37 ±18.89	346.99 ±20.17	385.11 ±19.20	287.66 ±16.79
Low dose of 1g/kg	98.45 ±3.49	149.4 10.11	195.11 ±17.52	229.90 ±15.17	248.95 ±21.62	258.90 ±18.16	289.65 ±18.16	299.19 ±16.29	328.26 ±19.12	362.17 ±15.22	263.72 ±13.98

Female rat weight increase table (2)

Natural law group x+SD	Before the administration	10 days x ± SD	20 days x ± SD	30 days x ± SD	40 days x ± SD	50 days x ± SD	60 days x ± SD	70 days x ± SD	80 days x ± SD	90 days x ± SD	Weightening finish (g) x ± SD
												Synopsis	101.95 ±7.51	139.00 ±10.03	178.82 ±10.20	209.72 ±16.19	227.88 ±15.53	238.40 ±17.61	257.63 ±11.92	279.53 14.19	290.13 ±13.58	299.95 ±18.11	198.00 ±15.06
Heavy dose of group 8g/kg	98.50 ±8.48	145.60 ±15.04	180.77 ±14.91	213.60 ±16.17	239.71 ±18.23	258.69 ±10.83	273.19 ±16.28	281.65 ±11.92	298.12 ±18.73	318.12 ±17.67	219.62 ±11.63
												Middle dosage group 4g/kg	94.55 ±6.96	14.10 ±13.22	185.10 14.12	218.92 ±17.21	231.06 ±15.80	248.63 ±11.26	266.18 ±16.23	280.1 6 ±11.61	293.62 ±13.87	320.65 ±17.28	226.10 ±17.85
Low dose of 1g/kg	101.95 ±7.51	153.25 ±12.15	189.11 ±14.27	213.73 ±11.21	229.16 ±14.58	240.33 ±16.98	261.19 ±14.41	281.77 ±16.90	301.90 ±13.34	317.19 ±16.21	215.24 ±16.21

Take medicine back, big oxygen routine blood test, routine urinalysis, hepatic and renal function table (3)

Group x+SD is described	RBC×10 12/L x±SD	Hbg/L x±SD	WBC×10 9/L x±SD	Pit×10 9/L x±SD	GPTu/L x±SD	BUVmmol/L x±SD	S％ x±SD	L％ x±SD
									Matched group	7.16 ±0.84	131.50 ±5.29	17.61 ±6.57	461.00 ±61.00	33.80 ±5.51	5.53 ±6.73	16.70 ±2.98	83.30 ±2.90
8g/kg administration group	7.34 ±0.27	133.19 ±6.74	11.78 ±5.32	450.00 ±62.53	34.5 ±6.41	5.29 ±1.06	15.44 ±2.18	74.25 ±2.12
									4g/kg administration group	7.22 ±0.34	130.00 5.27	12.88 ±4.009	383.00 ±100.78	59.4 ±30.14	4.63 ±1.03	15.33 ±2.64	85.40 ±3.14
1g/kg administration group	7.27 ±0.31	130.00 ±7.45	9.28 ±3.36	443.00 ±81.92	43.7 18.51	4.63 ±0.53	15.80 ±2.89	84.20 ±2.89

The specific embodiment:

The following example is intended to further describe for example the present invention, rather than limits the present invention by any way.Under the prerequisite that does not deviate from the spirit and principles in the present invention, any change or change that those of ordinary skills that the present invention did are realized easily all will fall in the claim scope of the present invention.

Embodiment 1:

Take by weighing each medicine by following weight ratio, Fel Ursi powder 1.5g, Concha Haliotidis 200g, Flos Chrysanthemi 200g, Concha Haliotidis (calcined) 60g, Fructus Lycii 200g, Rhizoma Alismatis (processed) 100g, Radix Gentianae 180g, Fructus Leonuri 180g are standby;

More than eight the flavor medicines, Fel Ursi powder is ground into fine powder; Concha Haliotidis (calcined) is ground into fine powder; Radix Gentianae is collected percolate or extracting solution with 50% ethanol percolation or reflux, extract,, reclaims ethanol, be concentrated into temperature in the time of 15 ℃, relative density is 1.45, and is standby; Get Concha Haliotidis and decoct after 30 minutes earlier, add all the other Flos Chrysanthemis, Fructus Lycii, Rhizoma Alismatis (processed), Fructus Leonuri four flavors, decoct with water three times, time was followed successively by 2 hours, 1 hour, 1 hour, and collecting decoction filters, filtrate be concentrated into temperature in the time of 15 ℃, relative density is 1.30, adds 2.5 times of amounts of ethanol, stir evenly, left standstill 24 hours, and filtered filtrate recycling ethanol, be concentrated into temperature in the time of 15 ℃, relative density is 1.45, merge with the Radix Gentianae fluid extract, drying is pulverized; Add Fel Ursi powder, Concha Haliotidis (calcined) fine powder and appropriate amount of starch, mixing is granulated, drying, and compacting is in blocks, and coating is promptly.

Embodiment 2:

Take by weighing each medicine by following weight ratio, Fel Ursi powder 4g, Concha Haliotidis 360g, Flos Chrysanthemi 360g, Concha Haliotidis (calcined) 120g, Fructus Lycii 360g, Rhizoma Alismatis (processed) 300g, Radix Gentianae 240g, Fructus Leonuri 240g are standby;

More than eight the flavor medicines, Fel Ursi powder is ground into fine powder; Concha Haliotidis (calcined) is ground into fine powder; Radix Gentianae is collected percolate or extracting solution with 80% ethanol percolation or reflux, extract,, reclaims ethanol, be concentrated into temperature in the time of 40 ℃, relative density is 1.30, and is standby; Get Concha Haliotidis and decoct after 30 minutes earlier, add all the other Flos Chrysanthemis, Fructus Lycii, Rhizoma Alismatis (processed), Fructus Leonuri four flavors, decoct with water three times, time was followed successively by 2 hours, 1 hour, 1 hour, and collecting decoction filters, it is 1.25 that filtrate is concentrated into temperature relative density in the time of 40 ℃, adds 2.5 times of amounts of ethanol, stirs evenly, left standstill 24 hours, and filtered filtrate recycling ethanol, be concentrated into temperature in the time of 40 ℃, relative density is 1.30, merge with the Radix Gentianae fluid extract, drying is pulverized; Add Fel Ursi powder, Concha Haliotidis (calcined) fine powder and appropriate amount of starch, mixing is granulated, drying, and compacting is in blocks, and coating is promptly.

Embodiment 3:

Take by weighing each medicine by following weight ratio, Fel Ursi powder 8g, Concha Haliotidis 560g, Flos Chrysanthemi 560g, Concha Haliotidis (calcined) 180g, Fructus Lycii 560g, Rhizoma Alismatis (processed) 500g, Radix Gentianae 400g, Fructus Leonuri 400g are standby;

More than eight the flavor medicines, Fel Ursi powder is ground into fine powder; Concha Haliotidis (calcined) is ground into fine powder; Radix Gentianae is collected percolate or extracting solution with 95% ethanol percolation or reflux, extract,, reclaims ethanol, be concentrated into temperature in the time of 65 ℃, relative density is 1.15, and is standby; Get Concha Haliotidis and decoct after 30 minutes earlier, add all the other Flos Chrysanthemis, Fructus Lycii, Rhizoma Alismatis (processed), Fructus Leonuri four flavors, decoct with water three times, time was followed successively by 2 hours, 1 hour, 1 hour, and collecting decoction filters, filtrate be concentrated into temperature in the time of 65 ℃, relative density is 1.10, adds 2.5 times of amounts of ethanol, stir evenly, left standstill 24 hours, and filtered filtrate recycling ethanol, be concentrated into temperature in the time of 65 ℃, relative density is 1.15, merge with the Radix Gentianae fluid extract, drying is pulverized; Add Fel Ursi powder, Concha Haliotidis (calcined) fine powder and appropriate amount of starch, mixing is granulated, drying, and compacting is in blocks, and coating is promptly.

Claims (3)

1, a kind of Chinese medicinal tablet for the treatment of ophthalmic diseases is characterized in that: make that its active component raw material medicine is made up of the component of following weight proportioning:

200～560 parts of 1.5～8 parts of Concha Haliotidis of Fel Ursi powder

60～180 parts of 200～560 parts of Concha Haliotidis (calcined) of Flos Chrysanthemi

100～500 parts of 200～560 parts of Rhizoma Alismatis (processed) of Fructus Lycii

180～400 parts of 180～400 parts of Fructus Leonuris of Radix Gentianae.

2, a kind of Chinese medicinal tablet for the treatment of ophthalmic diseases according to claim 1 is characterized in that: make that its active component raw material medicine is made up of the component of following weight proportioning:

360 parts of 4 parts of Concha Haliotidis of Fel Ursi powder

120 parts of 360 parts of Concha Haliotidis (calcined) of Flos Chrysanthemi

300 parts of 360 parts of Rhizoma Alismatis (processed) of Fructus Lycii

240 parts of 240 parts of Fructus Leonuris of Radix Gentianae.

3, the Chinese medicinal tablet of treatment ophthalmic diseases according to claim 1 and 2 is characterized in that: it is made according to following method:

More than eight the flavor medicines, Fel Ursi powder is ground into fine powder; Concha Haliotidis (calcined) is ground into fine powder; Radix Gentianae is collected percolate or extracting solution with 50%～95% ethanol percolation or reflux, extract,, reclaims ethanol, be concentrated into temperature in the time of 15 ℃～65 ℃, relative density is 1.15～1.45, and is standby; Get Concha Haliotidis and decoct after 30 minutes earlier, add all the other Flos Chrysanthemis, Fructus Lycii, Rhizoma Alismatis (processed), Fructus Leonuri four flavors, decoct with water three times, time was followed successively by 2 hours, 1 hour, 1 hour, and collecting decoction filters, filtrate be concentrated into temperature in the time of 15 ℃～65 ℃, relative density is 1.10～1.30, adds 2.5 times of amounts of ethanol, stir evenly, left standstill 24 hours, and filtered filtrate recycling ethanol, be concentrated into temperature in the time of 15 ℃～65 ℃, relative density is 1.15～1.45, merge with the Radix Gentianae fluid extract, drying is pulverized; Add Fel Ursi powder, Concha Haliotidis (calcined) fine powder and appropriate amount of starch, mixing is granulated, drying, and compacting is in blocks, and coating is promptly.