CN102416075B - Chinese medicinal composition for treating gastrointestinal disease and preparation method thereof - Google Patents

Chinese medicinal composition for treating gastrointestinal disease and preparation method thereof Download PDF

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CN102416075B
CN102416075B CN201110403302XA CN201110403302A CN102416075B CN 102416075 B CN102416075 B CN 102416075B CN 201110403302X A CN201110403302X A CN 201110403302XA CN 201110403302 A CN201110403302 A CN 201110403302A CN 102416075 B CN102416075 B CN 102416075B
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radix
subsequent use
moschus
rhizoma
crude drug
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CN102416075A (en
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陈坚
王磊
袁学海
王伟
杨瑾
王春晨
郝忻
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Lerentang Pharmaceutical Factory Of Jinyao Darentang Group Co ltd
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Lerentang Pharmaceutical Factory of Tianjin Zhongxin Pharmaceutical Group Co Ltd
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    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
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Abstract

The invention relates to a Chinese medicinal composition for treating a gastrointestinal disease and a preparation method thereof. The composition is prepared from costus root, agilawood, bitter orange, sandalwood, rhubarb, officinal magnolia bark, muskiness and croton cream serving as a basic formula and other medicaments. The composition is clinically and mainly used for treating diseases of acute diarrhea, irritable bowel syndrome and the like.

Description

Treatment gastrointestinal disease Chinese medicine composition and preparation method thereof
Technical field
The present invention relates to field of medicaments, particularly relate to treat gastrointestinal disease Chinese medicine composition and preparation method thereof.
Background technology
Diarrhoea can be divided into infectious and non-infectious two classes.Infectious diarrhea is divided into again antibacterial to be infected and viral infection; Noninfectious diarrhea then can be caused by the change of improper diet, food anaphylaxis, rule of life, abrupt change of climate even the many reasons such as nervous.Motherland's medical science thinks to have loose bowels and refers to that defecation frequency increases, feces is rare clearly, even such as water sample.The major lesions of having loose bowels is taste and intestine and small intestine.Its pathogenesis has being invaded by exogenous pathogen, injury due to diet, seven emotions discord, damp internal resistance and internal organs weakness etc.The clinical findings damp is caused a disease cold-damp and damp and hot dividing.Spleen and stomach function is swollen to be hindered is to be caused by many factors, has exopathogen impact, taste weakness itself, incoordination between the liver and spleen and kidney intestinal deficiency etc. all can cause spleen and stomach function not normal and have loose bowels.Survey data shows that diarrhoea sickness rate in urban population reaches 0.4 time/people, and the rural population sickness rate reaches 0.5 time/people.Although diarrhoea is minor illness, pathogenic factor also is diversified, and changes with epoch, environment.Can say that the diarrhoea of today and the diarrhoea before 20 years have had the change of essence from pathogeny.Along with the development in epoch, people's living standard attains the well-off standard substantially, and sanitary condition is improved greatly, fewer and feweri by the diarrhoea ratio that the antibacterial infection causes, on the contrary, because rhythm of life is accelerated, struggle for existence is fierce, and the functional diarrhea ratio that pressure causes greatly obviously rises.One studies show that, the diarrhoeal diseases people of China about 30% needs antibiosis usually to treat, and 70% does not need should not use antibiotic therapy yet.Consumer also more and more notices the untoward reaction of the products such as berberine, norfloxacin, and the harm that brings of abuse of antibiotics.Diarrhoea market is except the low side antibiotic products such as berberine, norfloxacin, some non-antibiotic products have also been introduced in recent years, such as dioctahedral smectite, Birid Triple Viable etc., but be positioned at high-end consumer groups, for most of consumer groups, its price positioning does not conform to the consumption location of such minor illness of suffering from diarrhoea with consumer.Analysis expert thinks, mainly is take viral as main in urban market diarrhoea, and take bacterial infection as main, if according to the principle of the market segments, at present a lot of products all are difficult to cover the whole market in the rural area.For alteration of intestinal flora person, available little ecological active bacteria formulation provides probiotics, improves intestinal environment, improves intestinal absorption, kinestate.As: bifidobacteria viable bacteria preparation (Bifidobiogen), Peifeikang Capsule, bacillus cicheniformis (Bacillus Licheniformis Capsule capsule); The intestinal mucosa protective agent: two eight body Montmorillonitums (dioctahedral smectite), the protection intestinal mucosa can suppress fixedly mycin, promotes the intestinal mucosal lesion reparation; Contain the creosote component preparation: the excessive secretion that can suppress intestinal juice.
At present on the market gastrointestinal disease treating pill is mainly used in treating the diarrhoea that dyspepsia causes, enteritis, and bacillary dysentery, distension and fullness in the abdomen, stomachache, the food stagnation infantile dyspepsia, its pharmacological action is higher than like product: diarrhea, antibiotic, antiviral, four kinds of functions of adjusting gastrointestinal function are also deposited.But contain Cinnabaris in its prescription, its effect is tranquillizing the mind by relieving convulsion, but contain hydrargyrum in the Cinnabaris, hydrargyrum is very large to the harm of human body, it is the process of a subtle lasting absorption, and human body Long Term Contact hydrargyrum can cause chronic poisoning: nerve, digestion, hormonal system and kidney to the people produce harm; Neurasthenic crowd may cause the symptoms such as headache, dizziness, insomnia, hypomnesis, malaise; And women's Long Term Contact hydrargyrum of anemia of pregnant woman and age of sucking, the health that also may endanger fetus and baby.Be subject to certain restriction when mercurous medicine exports other countries in addition, required mercury content less than 0.5ppm, to require then stricter for some European countries such as Singapore.
Summary of the invention
Problem to be solved by this invention provides treatment gastrointestinal disease Chinese medicine composition.
Another problem to be solved by this invention provides the preparation method for the treatment of gastrointestinal disease Chinese medicine composition.
The present invention treats the gastrointestinal disease Chinese medicine composition, is to add other crude drug by square foundation to make according to the following weight proportioning:
Described square foundation medicine is: the Radix Aucklandiae 150～600g, Lignum Aquilariae Resinatum 150～600g, Fructus Aurantii 150～600g, Lignum Santali Albi 90～360g, Radix Et Rhizoma Rhei 90～360g, Cortex Magnoliae Officinalis 150～600g, Moschus 4.5～18g, Semen Crotonis Pulveratum 60～240g;
Described other crude drug are:
Fructus Jujubae 500～2000g, Rhizoma Chuanxiong 90～360g, Radix Codonopsis 150～600g and Rhizoma Coptidis 100～400g;
Perhaps Fructus Jujubae 500～2000g, Rhizoma Chuanxiong 90～360g, the Rhizoma Atractylodis Macrocephalae 150～600g and Rhizoma Coptidis 100～400g;
Perhaps Fructus Jujubae 500～2000g, Rhizoma Chuanxiong 90～360g, Radix Codonopsis 150～600g, Poria 150～600g, the Rhizoma Atractylodis Macrocephalae 150～600g and Rhizoma Coptidis 100～400g;
Perhaps Rhizoma Chuanxiong 90～360g, Seem Lablab Album 150～600g and Rhizoma Dioscoreae 150～600g;
Perhaps Fructus Jujubae 500～2000g, Rhizoma Chuanxiong 90～360g, Semen Arecae 90～360g and Fructus Crataegi 150～600g;
Perhaps Fructus Jujubae 500～2000g, Rhizoma Chuanxiong 90～360g, Poria 150～600g and JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata) 150～600g;
Perhaps Fructus Jujubae 500～2000g, Rhizoma Chuanxiong 90～360g, Endothelium Corneum Gigeriae Galli 90～360g, JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata) 150～600g and Pericarpium Citri Reticulatae 150～600g;
Perhaps Fructus Jujubae 500～2000g, Rhizoma Chuanxiong 90～360g, Radix Angelicae Sinensis 90～360g;
Perhaps Fructus Jujubae 500～2000g, the Radix Paeoniae Alba 90～360g and Radix Angelicae Sinensis 90～360g;
Perhaps Fructus Jujubae 500～2000g, Rhizoma Chuanxiong 90～360g, Radix Scutellariae 150～600g and Rhizoma Coptidis 150～600g;
In a kind of.
The present invention preferably treats the gastrointestinal disease Chinese medicine composition, is to add other crude drug by square foundation to make according to the following weight proportioning:
Described square foundation medicine is: the Radix Aucklandiae 250～400g, Lignum Aquilariae Resinatum 250～400g, Fructus Aurantii 250～400g, Lignum Santali Albi 150～250g, Radix Et Rhizoma Rhei 150～250g, Cortex Magnoliae Officinalis 250～400g, Moschus 6～12g, Semen Crotonis Pulveratum 100～150g;
Described other crude drug are:
Fructus Jujubae 800～1200g, Rhizoma Chuanxiong 150～250g, Radix Codonopsis 250～400g and Rhizoma Coptidis 150～300g;
Perhaps Fructus Jujubae 800～1200g, Rhizoma Chuanxiong 150～250g, the Rhizoma Atractylodis Macrocephalae 250～400g and Rhizoma Coptidis 150～300g;
Perhaps Fructus Jujubae 800～1200g, Rhizoma Chuanxiong 150～250g, Radix Codonopsis 250～400g, Poria 250～400g, the Rhizoma Atractylodis Macrocephalae 250～400g and Rhizoma Coptidis 150～300g;
Perhaps Rhizoma Chuanxiong 150～250g, Seem Lablab Album 250～400g and Rhizoma Dioscoreae 250～400g;
Perhaps Fructus Jujubae 800～1200g, Rhizoma Chuanxiong 150～250g, Semen Arecae 120～250g and Fructus Crataegi 250～400g;
Perhaps Fructus Jujubae 800～1200g, Rhizoma Chuanxiong 150～250g, Poria 250～400g and JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata) 250～400g;
Perhaps Fructus Jujubae 800～1200g, Rhizoma Chuanxiong 150～250g, Endothelium Corneum Gigeriae Galli 120～250g, JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata) 250～400g and Pericarpium Citri Reticulatae 150～600g;
Perhaps Fructus Jujubae 800～1200g, Rhizoma Chuanxiong 150～250g, Radix Angelicae Sinensis 120～250g;
Perhaps Fructus Jujubae 800～1200g, the Radix Paeoniae Alba 120～250g and Rhizoma Chuanxiong 150～250g;
Perhaps Fructus Jujubae 800～1200g, Rhizoma Chuanxiong 150～250g, Radix Scutellariae 250～400g and Rhizoma Coptidis 250～400g;
In a kind of.
The present invention is preferred treatment gastrointestinal disease Chinese medicine composition further, is to add other crude drug by square foundation to make according to the following weight proportioning:
Described square foundation medicine is: Radix Aucklandiae 300g, Lignum Aquilariae Resinatum 300g, Fructus Aurantii 300g, Lignum Santali Albi 180g, Radix Et Rhizoma Rhei 180g, Cortex Magnoliae Officinalis 300g, Moschus 9g, Semen Crotonis Pulveratum 120g;
Described other crude drug are:
Fructus Jujubae 1000g, Rhizoma Chuanxiong 180g, Radix Codonopsis 300g and Rhizoma Coptidis 200g;
Perhaps Fructus Jujubae 1000g, Rhizoma Chuanxiong 180g, Rhizoma Atractylodis Macrocephalae 300g and Rhizoma Coptidis 200g;
Perhaps Fructus Jujubae 1000g, Rhizoma Chuanxiong 180g, Radix Codonopsis 300g, Poria 300g, Rhizoma Atractylodis Macrocephalae 300g and Rhizoma Coptidis 200g;
Perhaps Rhizoma Chuanxiong 180g, Seem Lablab Album 300g and Rhizoma Dioscoreae 300g;
Perhaps Fructus Jujubae 1000g, Rhizoma Chuanxiong 180g, Semen Arecae 180g and Fructus Crataegi 300g;
Perhaps Fructus Jujubae 1000g, Rhizoma Chuanxiong 180g, Poria 300g and JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata) 300g;
Perhaps Fructus Jujubae 1000g, Rhizoma Chuanxiong 180g, Endothelium Corneum Gigeriae Galli 180g, JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata) 300g and Pericarpium Citri Reticulatae 300g;
Perhaps Fructus Jujubae 1000g, Rhizoma Chuanxiong 180g, Radix Angelicae Sinensis 180g;
Perhaps Fructus Jujubae 1000g, Radix Paeoniae Alba 180g and Rhizoma Chuanxiong 180g;
Perhaps Fructus Jujubae 1000g, Rhizoma Chuanxiong 180g, Radix Scutellariae 300g and Rhizoma Coptidis 300g;
In a kind of.
The present invention treats the gastrointestinal disease Chinese medicine composition, can adopt following methods to prepare active component for crude drug: such as one or several use in conjunction preparations in water extraction, decoction and alcohol sedimentation technique, extraction, infusion process, percolation, reflux extraction, continuous circumfluence extraction method, the macroreticular resin absorbing method.But in order to make each crude drug of this medicine bring into play better drug effect, the present invention preferably adopts following technique to extract active component to raw material, and makes the present invention and treat the gastrointestinal disease Chinese medicine composition, but this can not limit protection scope of the present invention.
The present invention treats the gastrointestinal disease Chinese medicine composition, and employing is prepared as follows method and makes:
A. getting the weight proportion crude drug, to prepare active component according to present conventional preparation method for subsequent use;
B. the active component that obtains is made preparation.
The preparation that the present invention treats among the gastrointestinal disease Chinese medicine composition preparation method step b is tablet, granule, honey pill agent, watered pill, drop pill, hard capsule, soft capsule, patch, cataplasma, ointment, gel.
The Fructus Aurantii that the present invention treats in the gastrointestinal disease Chinese medicine composition is stir-baked Fructus Aurantii in bran; Cortex Magnoliae Officinalis is Cortex Magnoliae Officinalis (processed with ginger); Fructus Jujubae is the Fructus Jujubae of enucleation.
The present invention treats the application of gastrointestinal disease Chinese medicine composition in preparation treatment irritable bowel syndrome medicine.
The present invention treats the application of gastrointestinal disease Chinese medicine composition in preparation treatment acute diarrhea, bacillary dysentery, enteritis, lienteric diarrhea medicine.
The present invention treats the gastrointestinal disease Chinese medicine composition in preparation treatment eliminating turbid pathogen with aromatics, regulating QI to relieve pain, the application in the consumer product dredge stasis medicine.
The present invention treats the gastrointestinal disease Chinese medicine composition at preparation treatment invigorating the spleen to arrest diarrhea, antidiarrheal dysentery relieving, and the application in the blood dysentery relieving medicine.
More than form when producing and to increase or to reduce according to corresponding ratio, can be with kilogram or take ton as unit such as large-scale production, small-scale production also can be in grams, and weight can increase or reduce, but the crude drug material weight proportion constant rate between each composition.
In order to understand better the present invention, further set forth the beneficial effect of medicine of the present invention below by Drug therapy chronic gastrointestinal disease 100 routine clinical verification case summaries of the present invention.Below used medicine of the present invention prepares according to embodiment 6 methods in the test.
One, observational technique
(1) object of observation: this group case is the out-patient, and untreated or treatment be person more, comprises functional diarrhea, functional dyspepsia, and irritable bowel syndrome, chronic and infective diarrhea is the object of observation.
(2) diagnostic criteria
Adopt " Rome Ⅱ criteria in 1999 ", selected case meets the diagnostic criteria of functional diarrhea, functional dyspepsia, irritable bowel syndrome, chronic and infective diarrhea.All cases are got rid of Stomach duodenum, colon organic disease all through stomach, colon scope or x-ray barium examination.
(3) rejecting standard
1, organic digestive system disease person is arranged, such as polyp, tumor etc.
2, Liver and kidney is arranged, endocrine, the serious protopathy person of immune system and blood system: diabetes, uremia, hepatopathy etc.
3, Pregnant and lactant women.
4, do not meet diagnostic criteria.
(4) symptom degree evaluation standard
With reference to " new Chinese medicine clinical guidance principle ": according to symptom light, in, severe remembers respectively 1,2,3 minute.
1, symptom scoring method:
(1) asymptomatic (-): remember 0 minute;
(2) slight (+): note 1 minute occurs once in a while;
(3) moderate (++): note 2 minutes often occur;
(4) severe (+++): sustainable existence note 3 minutes.
2, have loose bowels:
(1) the asymptomatic and soft change (-) that is shaped: every day, 1-2 note was 0 minute;
(2) slight (+): symptom is slight, does not affect live and work, can stand, and stool every day 2-3 time, mushy stool or Mucous Stool are remembered 1 minute;
(3) moderate (++): symptom is heavier, has affected work, life, still can stand, and stool is the egg style, every day 4-5 time, or the Mucous Stool moderate is remembered 2 minutes;
(4) severe (+++): serious symptom, hinder one's work and live, endurable, rare watery stool, every day is more than 6 times, or a large amount of notes of Mucous Stool 3 minutes.
3, the deciding degree standard of disease
(1) severe: the cardinal symptom integration=＞total mark 70%;
(2) moderate: 70% of 30%＜=cardinal symptom integration＜total mark;
(3) slight: 30% of cardinal symptom integration＜=total mark;
(5) curative effect determinate standard and statistical method
Reference " new Chinese medicine clinical guidance principle " is as standard.
1, curative effect determinate standard:
(1) cure: cardinal symptom disappears, and stool is shaped, and every day 1-2 time, therapeutic index is 100%;
(2) produce effects: main clinic symptoms disappears substantially, times of defecation every day 2-3 time, 75%＜=therapeutic index＜100%;
(3) effective: main clinic symptoms takes a turn for the better, and stool shape and time number average take a favorable turn 30%＜=therapeutic index＜75%;
(4) invalid: main clinic symptoms is without change, therapeutic index＜30%;
The total score value of cardinal symptom * 100% before curative effect of disease index=(treating the rear total score value of cardinal symptom of the total score value of front cardinal symptom-treatment)/treatment.
2, individual event symptom the standard of curative effect evaluation:
(1) cure: after finishing the course for the treatment of, transference cure;
(2) produce effects: after curative effect finished, the symptom classification reduced 2 grades;
(3) effective: after curative effect finished, the symptom classification reduced 1 grade;
(4) invalid: as not reach above-mentioned standard.
(6) observation index
1, health giving quality is observed:
(1) before the treatment, the variation of sings and symptoms in the course for the treatment of.
(2) every day times of defecation, amount.
(3) stool shape is just wait such as bloody purulent stool, Mucous Stool and rare water.
(4) stool routine examination inspection: erythrocyte, leukocyte and pus cell quantity in the stool have or not indigestion dietary fiber, fat drop etc.
(5) the part patient does just and cultivates.
(6) the part patient does colonoscope, intestinal radiography, gastroscope.
3, safety is observed:
(1) blood, routine urianlysis.
(2) just routine test.
4, main clinic symptoms is observed:
(1) functional diarrhea: diarrhoea, with tenesmus, watery stool, Mucous Stool.
(2) functional dyspepsia: Abdeminal pain, early full, belch, Upper abdominal pain, nausea and vomiting, acid regurgitation.
(3) irritable bowel syndrome: stomachache, abdominal distention, diarrhoea, just not to the utmost, times of defecation, shape.
(4) chronic and infective diarrhea: diarrhoea, stomachache, tenesmus, the dense hemafecia of mucus.
Two, clinical data
Therapeutic Method
The all cases other treatment medicine of stopping using during medication uses merely medicine of the present invention, usage and dosage be 10 balls/time, 3 times/days, be 4 weeks the course for the treatment of.
Statistical method
Enumeration data is used X 2Check, measurement data are used the t check.
Observed result
1, each sick clinical treatment front and back total effects of planting is observed, and is as shown in table 1
Each sick clinical treatment front and back total effects table of planting of table 1
Figure BSA00000630647800071
2, each sick clinical treatment front and back obvious effective rate comparable situation of planting is as shown in table 2
Each sick clinical treatment front and back obvious effective rate comparison sheet of planting of table 2
Figure BSA00000630647800072
Four kinds of sick X 2Relatively, P＞0.05 not statistically significant illustrates that this medicine all has significant therapeutic effect to above-mentioned 4 kinds of diseases.
Three, the result shows
1, various chronic gastrointestinal disease had good therapeutical effect
Clinical effectiveness shows that the sick statistical effect of planting of each of Drug therapy chronic gastrointestinal disease of the present invention is learned there was no significant difference, and illustrating all has good therapeutical effect to various chronic gastrointestinal disease.
2, has the obvious effect that improves chronic gastrointestinal disease patient clinical symptom
Clinical effectiveness shows that medicine of the present invention can obviously be alleviated clinical symptoms.To single sick successful that improves of planting primary symptom, total effective rate is all more than 85%.
3, do not find apparent side effect during the medication.
The specific embodiment
Further set forth by the following examples the preparation method of medicine of the present invention.
Embodiment 1
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 150g, Lignum Aquilariae Resinatum 150g, Fructus Aurantii 150g, Lignum Santali Albi 90g, Radix Et Rhizoma Rhei 90g, Cortex Magnoliae Officinalis 150g, Moschus 4.5g, Semen Crotonis Pulveratum 60g, Fructus Jujubae 500g, Rhizoma Chuanxiong 90g, Radix Codonopsis 150g and Rhizoma Coptidis 100g are for subsequent use;
B. above crude drug, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is for subsequent use; The pulverizing such as the Radix Aucklandiae, Lignum Aquilariae Resinatum, Fructus Aurantii, Lignum Santali Albi, Radix Et Rhizoma Rhei, Cortex Magnoliae Officinalis, CO 2Supercritical extraction; Get extract, add an amount of anhydrous alcohol solution, carry out enclose with an amount of β-CD, drying namely gets clathrate, and is for subsequent use; With the medicinal residues ethanol extraction secondary behind the above-mentioned supercritical extraction, merge secondary filtrate, Recycled ethanol is concentrated for subsequent use; Get Fructus Jujubae and decoct with water secondary, filter; Merging filtrate, concentrated, with above-mentioned alcohol extract condensed cream mixing, drying is ground into fine powder, with clathrate, Semen Crotonis Pulveratum, the Moschus mixing that sieves, sieves again, and is for subsequent use; Make tablet according to method for preparing tablet thereof.
Embodiment 2
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 600g, Lignum Aquilariae Resinatum 600g, Fructus Aurantii 600g, Lignum Santali Albi 360g, Radix Et Rhizoma Rhei 360g, Cortex Magnoliae Officinalis 600g, Moschus 18g, Semen Crotonis Pulveratum 240g, Fructus Jujubae 2000g, Rhizoma Chuanxiong 360g, Radix Codonopsis 600g and Rhizoma Coptidis 400g are for subsequent use;
B. above crude drug, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is for subsequent use; The Radix Aucklandiae, Lignum Aquilariae Resinatum, Fructus Aurantii, Lignum Santali Albi, Radix Et Rhizoma Rhei, Cortex Magnoliae Officinalis etc. are broken into coarse powder, add water, soak, and decocting boils distillation, collect volatile oil, and be with after β-CD inclusion, for subsequent use; Decocting liquid filters, and filtrate is concentrated for subsequent use, and medicinal residues and Lignum Santali Albi coarse powder add alcohol reflux 2 times, filters; Merge secondary filtrate, concentrated, drying, for subsequent use; Get Fructus Jujubae, add decocting and boil secondary, filter; Merge secondary filtrate, concentrated, drying, the above-mentioned fine powder that is dried and crushed into, with Semen Crotonis Pulveratum, Moschus mixing, for subsequent use; According to the agent of process for producing granula granulation, and get final product.
Embodiment 3
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 150g, Lignum Aquilariae Resinatum 150g, Fructus Aurantii 150g, Lignum Santali Albi 90g, Radix Et Rhizoma Rhei 90g, Cortex Magnoliae Officinalis 150g, Moschus 4.5g, Semen Crotonis Pulveratum 60g, Fructus Jujubae 500g, Rhizoma Chuanxiong 90g, Rhizoma Atractylodis Macrocephalae 150g and Rhizoma Coptidis 100g are for subsequent use;
B. above crude drug, Semen Crotonis Pulveratum, Moschus are ground into respectively fine powder; All the other Radix Aucklandiae, Lignum Aquilariae Resinatum, Fructus Aurantii, Lignum Santali Albi, Radix Et Rhizoma Rhei, Cortex Magnoliae Officinalis etc. decoct with water 2 times, and each 2 hours, collecting decoction filtered, and is condensed into thick paste, adds Semen Crotonis Pulveratum, Moschus powder in above-mentioned thick paste, and mixing is for subsequent use; Get an amount of polyethylene glycol 6000, heating makes melting, adds above-mentioned thick paste and Semen Crotonis Pulveratum, Moschus mixture of powders, mixing, and adopting a speed is 85～90/min, splashes in the liquid paraffin of cooling, makes drop pill, and get final product.
Embodiment 4
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 600g, Lignum Aquilariae Resinatum 600g, Fructus Aurantii 600g, Lignum Santali Albi 360g, Radix Et Rhizoma Rhei 360g, Cortex Magnoliae Officinalis 600g, Moschus 18g, Semen Crotonis Pulveratum 240g, Fructus Jujubae 2000g, Rhizoma Chuanxiong 360g, Rhizoma Atractylodis Macrocephalae 600g and Rhizoma Coptidis 400g are for subsequent use;
B. above crude drug, Semen Crotonis Pulveratum, Moschus are ground into respectively fine powder; All the other crude drug decoct with water 2 times, and each 3 hours, collecting decoction filtered, and is condensed into thick paste, adds above-mentioned thick paste and Semen Crotonis Pulveratum, Moschus powder, and mixing is for subsequent use; Get an amount of Macrogol 4000, heating makes melting, adds said mixture, mixing, and adopting a speed is 60～80/min, splashes in the methyl-silicone oil of cooling, makes drop pill, and get final product.
Embodiment 5
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 150g, Lignum Aquilariae Resinatum 150g, Fructus Aurantii 150g, Lignum Santali Albi 90g, Radix Et Rhizoma Rhei 90g, Cortex Magnoliae Officinalis 150g, Moschus 4.5g, Semen Crotonis Pulveratum 60g, Fructus Jujubae 500g, Rhizoma Chuanxiong 90g, Radix Codonopsis 150g, Poria 150g, Rhizoma Atractylodis Macrocephalae 150g and Rhizoma Coptidis 100g are for subsequent use;
B. above crude drug, Semen Crotonis Pulveratum, Moschus are ground into respectively fine powder; All the other crude drug decoct with water 3 times, and each 2 hours, collecting decoction filtered, and is condensed into thick paste, adds above-mentioned thick paste and Semen Crotonis Pulveratum, Moschus powder, and mixing is for subsequent use; Get an amount of polyethylene glycol 6000: polyethylene glycol 1500 is 3: 1 mixture, and heating dissolves, and adds above-mentioned thick paste and Semen Crotonis Pulveratum, Moschus powder, mixing, and adopting a speed is 20～80/min, splashes in the liquid paraffin of cooling, makes drop pill, and get final product.
Embodiment 6
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 600g, Lignum Aquilariae Resinatum 600g, Fructus Aurantii 600g, Lignum Santali Albi 360g, Radix Et Rhizoma Rhei 360g, Cortex Magnoliae Officinalis 600g, Moschus 18g, Semen Crotonis Pulveratum 240g, Fructus Jujubae 2000g, Rhizoma Chuanxiong 360g, Radix Codonopsis 600g, Poria 600g, Rhizoma Atractylodis Macrocephalae 600g and Rhizoma Coptidis 400g are for subsequent use;
B. above crude drug, Semen Crotonis Pulveratum, Moschus are ground into respectively fine powder; All the other crude drug decoct with water 2 times, and each 2 hours, collecting decoction filters, and is condensed into thick paste, and was for subsequent use; Taking polyethylene glycol 6000: the mixture Polyethylene Glycol of Macrogol 4000=4: 3 is an amount of, and heating makes melting, adds above-mentioned thick paste and Semen Crotonis Pulveratum, Moschus powder, mixing, adopting a speed is 40～60/min, splashes in the liquid paraffin of cooling, make drop pill, and get final product.
Embodiment 7
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 150g, Lignum Aquilariae Resinatum 150g, Fructus Aurantii 150g, Lignum Santali Albi 90g, Radix Et Rhizoma Rhei 90g, Cortex Magnoliae Officinalis 150g, Moschus 4.5g, Semen Crotonis Pulveratum 60g, Rhizoma Chuanxiong 90g, Seem Lablab Album 150g and Rhizoma Dioscoreae 150g are for subsequent use;
B. above crude drug, Semen Crotonis Pulveratum, Moschus are ground into respectively fine powder; All the other crude drug decoct with water 2 times, and each 2 hours, collecting decoction filters, and is condensed into thick paste, and was for subsequent use; Get an amount of polyethylene glycol 6000: polyethylene glycol 6000 and the Macrogol 4000 mixture of Macrogol 4000=5: 1 add above-mentioned thick paste and Semen Crotonis Pulveratum, Moschus powder, mixing, heating dissolves, and adopting a speed is 65～75/min, splashes in the liquid paraffin of cooling, make drop pill, and get final product.
Embodiment 8
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 600g, Lignum Aquilariae Resinatum 600g, Fructus Aurantii 600g, Lignum Santali Albi 360g, Radix Et Rhizoma Rhei 360g, Cortex Magnoliae Officinalis 600g, Moschus 18g, Semen Crotonis Pulveratum 240g, Rhizoma Chuanxiong 360g, Seem Lablab Album 600g and Rhizoma Dioscoreae 600g are for subsequent use;
B. above crude drug, Semen Crotonis Pulveratum, Moschus are ground into respectively fine powder; All the other crude drug decoct with water 2 times, and each 2 hours, collecting decoction filters, and is condensed into thick paste, and was for subsequent use; Taking polyethylene glycol 6000: the mixture Polyethylene Glycol of Macrogol 4000=3: 2 is an amount of, and heating makes melting, adds above-mentioned thick paste and Semen Crotonis Pulveratum, Moschus powder, mixing, adopt dripping speed is 50～60/min, splashes into methyl-silicone oil: in the condensed fluid of liquid Paraffin=4: 1, namely get drop pill, and get final product.
Embodiment 9
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 150g, Lignum Aquilariae Resinatum 150g, Fructus Aurantii 150g, Lignum Santali Albi 90g, Radix Et Rhizoma Rhei 90g, Cortex Magnoliae Officinalis 150g, Moschus 4.5g, Semen Crotonis Pulveratum 60g, Fructus Jujubae 500g, Rhizoma Chuanxiong 90g, Semen Arecae 90g and Fructus Crataegi 150g are for subsequent use;
B. above crude drug, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is for subsequent use; The crude drug such as the Radix Aucklandiae, Lignum Aquilariae Resinatum, Rhizoma Coptidis, Fructus Aurantii Immaturus, Rhizoma Atractylodis, Rhizoma Chuanxiong are ground into coarse powder, add 16 times of water gagings, soak 4 hours, and decocting boils distillation 8h altogether, collects volatile oil, and is with after β-CD inclusion, for subsequent use; Decocting liquid filters, and relative density 1.25-1.30 was for subsequent use when filtrate was concentrated into 60 ℃, and medicinal residues and Lignum Santali Albi coarse powder add 70% alcohol reflux 2 times, for the first time 2h; 1h filters for the second time; Merge secondary filtrate, relative density 1.20-1.25 when being concentrated into 60 ℃, drying, for subsequent use; Get Fructus Jujubae, add decocting and boil secondary, each 2h filters; Merge secondary filtrate, and relative density 1.28-1.32 when being concentrated into 60 ℃ (60 ℃, drying, for subsequent use with Semen Crotonis Pulveratum, Moschus mixing with the above-mentioned fine powder that is dried and crushed into, the granulation agent.
Embodiment 10
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 600g, Lignum Aquilariae Resinatum 600g, Fructus Aurantii 600g, Lignum Santali Albi 360g, Radix Et Rhizoma Rhei 360g, Cortex Magnoliae Officinalis 600g, Moschus 18g, Semen Crotonis Pulveratum 240g, Fructus Jujubae 2000g, Rhizoma Chuanxiong 360g, Semen Arecae 360g and celestial short, bristly hair or beard 600g are for subsequent use;
B. above crude drug, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is for subsequent use; The crude drug such as all the other Radix Aucklandiae, Lignum Aquilariae Resinatum, Rhizoma Coptidis, Fructus Aurantii Immaturus, Rhizoma Atractylodis, Rhizoma Chuanxiong, Lignum Santali Albi are ground into 40 purpose powder, CO 2Supercritical extraction, extracting pressure 5MPa, 35 ℃ of temperature, CO 2Flow velocity 20L/h, extraction 2h; Get extract, add an amount of anhydrous alcohol solution, with an amount of β-CD, adopt polishing to carry out enclose, in 40 ℃ of vacuum dryings, namely get clathrate, for subsequent use; Medicinal residues behind the above-mentioned supercritical extraction are added 60% ethanol extraction secondary, merge secondary filtrate, Recycled ethanol to relative density is that 1.25-1.30 (60 ℃) is for subsequent use; Get Fructus Jujubae and decoct with water secondary, each 2h filters; Merging filtrate is concentrated into relative density 1.25-1.30 (60 ℃), and with above-mentioned alcohol extract condensed cream mixing, drying is ground into fine powder, with clathrate, Semen Crotonis Pulveratum, the Moschus mixing that sieves, crosses 80 mesh sieves again, and is for subsequent use, makes tablet according to method for preparing tablet thereof.
Embodiment 11
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 150g, Lignum Aquilariae Resinatum 150g, Fructus Aurantii 150g, Lignum Santali Albi 90g, Radix Et Rhizoma Rhei 90g, Cortex Magnoliae Officinalis 150g, Moschus 4.5g, Semen Crotonis Pulveratum 60g, Fructus Jujubae 500g, Rhizoma Chuanxiong 90g, Poria 150g and JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata) 150g are for subsequent use;
B. above crude drug, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is for subsequent use; The pulverizing such as all the other Radix Aucklandiae, Lignum Aquilariae Resinatum, Fructus Aurantii, Lignum Santali Albi, Radix Et Rhizoma Rhei, Cortex Magnoliae Officinalis, CO 2Supercritical extraction; Get extract, add an amount of anhydrous alcohol solution, carry out enclose with an amount of β-CD, drying namely gets clathrate, and is for subsequent use; With the medicinal residues ethanol extraction secondary behind the above-mentioned supercritical extraction, merge secondary filtrate, Recycled ethanol is concentrated for subsequent use; Get Fructus Jujubae and decoct with water secondary, filter; Merging filtrate, concentrated, with above-mentioned alcohol extract condensed cream mixing, drying is ground into fine powder, with clathrate, Semen Crotonis Pulveratum, the Moschus mixing that sieves, sieves again, and is for subsequent use, encapsulated, and get final product.
Embodiment 12
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 600g, Lignum Aquilariae Resinatum 600g, Fructus Aurantii 600g, Lignum Santali Albi 360g, Radix Et Rhizoma Rhei 360g, Cortex Magnoliae Officinalis 600g, Moschus 18g, Semen Crotonis Pulveratum 240g, Fructus Jujubae 2000g, Rhizoma Chuanxiong 360g, Poria 600g and JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata) 600g are for subsequent use;
B. above crude drug, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is for subsequent use; All the other Radix Aucklandiae, Lignum Aquilariae Resinatum, Fructus Aurantii, Lignum Santali Albi, Radix Et Rhizoma Rhei, Cortex Magnoliae Officinalis etc. are ground into coarse powder, add water, soak, and decocting boils distillation, collect volatile oil, and be with after β-CD inclusion, for subsequent use; Decocting liquid filters, and filtrate is concentrated for subsequent use, and medicinal residues and Lignum Santali Albi coarse powder add alcohol reflux 2 times, filters; Merge secondary filtrate, concentrated, drying, for subsequent use; Get Fructus Jujubae, add decocting and boil secondary, filter; Merge secondary filtrate, concentrated, drying, the above-mentioned fine powder that is dried and crushed into, for subsequent use, encapsulated with Semen Crotonis Pulveratum, Moschus mixing, and get final product.
Embodiment 13
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 150g, Lignum Aquilariae Resinatum 150g, Fructus Aurantii 150g, Lignum Santali Albi 90g, Radix Et Rhizoma Rhei 90g, Cortex Magnoliae Officinalis 150g, Moschus 4.5g, Semen Crotonis Pulveratum 60g, Fructus Jujubae 500g, Rhizoma Chuanxiong 90g, Endothelium Corneum Gigeriae Galli 90g, JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata) 150g and Pericarpium Citri Reticulatae 150g are for subsequent use;
B. above crude drug, Semen Crotonis Pulveratum, Moschus are ground into respectively fine powder; All the other crude drug decoct with water 3 times, and each 1 hour, collecting decoction filtered, and is condensed into thick paste; In above-mentioned thick paste, add Semen Crotonis Pulveratum, Moschus powder, mixing, for subsequent use, encapsulated, and get final product.
Embodiment 14
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 600g, Lignum Aquilariae Resinatum 600g, Fructus Aurantii 600g, Lignum Santali Albi 360g, Radix Et Rhizoma Rhei 360g, Cortex Magnoliae Officinalis 600g, Moschus 18g, Semen Crotonis Pulveratum 240g, Fructus Jujubae 2000g, Rhizoma Chuanxiong 360g, Endothelium Corneum Gigeriae Galli 360g, JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata) 600g and Pericarpium Citri Reticulatae 600g are for subsequent use;
B. go up ten flavors, Semen Crotonis Pulveratum, Moschus are ground into respectively fine powder; All the other crude drug decoct with water 2 times, and each 3 hours, collecting decoction filtered, and is condensed into thick paste; In above-mentioned thick paste, add Semen Crotonis Pulveratum, Moschus powder, mixing, for subsequent use; Encapsulated, and get final product.
Embodiment 15
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 150g, Lignum Aquilariae Resinatum 150g, Fructus Aurantii 150g, Lignum Santali Albi 90g, Radix Et Rhizoma Rhei 90g, Cortex Magnoliae Officinalis 150g, Moschus 4.5g, Semen Crotonis Pulveratum 60g, Fructus Jujubae 500g, Rhizoma Chuanxiong 90g, Radix Angelicae Sinensis 90g is for subsequent use;
B. above crude drug, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is for subsequent use; All the other Radix Aucklandiae, Lignum Aquilariae Resinatum, Fructus Aurantii, Lignum Santali Albi, Radix Et Rhizoma Rhei, Cortex Magnoliae Officinalis etc. are ground into 80 purpose powder, CO 2Supercritical extraction, extracting pressure 40MPa, temperature 60 C, CO 2Flow velocity 35L/h, extraction 5h; Get extract, add an amount of anhydrous alcohol solution, with an amount of β-CD, adopt polishing to carry out enclose, in 40 ℃ of vacuum dryings, namely get clathrate, for subsequent use; Medicinal residues behind the above-mentioned supercritical extraction are added 60% ethanol extraction secondary, merge secondary filtrate, relative density is that 1.25-1.30 is for subsequent use during Recycled ethanol to 60 ℃; Get Fructus Jujubae and decoct with water secondary, each 2h filters; Merging filtrate, relative density 1.25-1.30 when being concentrated into 60 ℃, with above-mentioned alcohol extract condensed cream mixing, drying is ground into fine powder, with clathrate, Semen Crotonis Pulveratum, the Moschus mixing that sieves, crosses 80 mesh sieves again, and is for subsequent use; Encapsulated, and get final product.
Embodiment 16
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 600g, Lignum Aquilariae Resinatum 600g, Fructus Aurantii 600g, Lignum Santali Albi 360g, Radix Et Rhizoma Rhei 360g, Cortex Magnoliae Officinalis 600g, Moschus 18g, Semen Crotonis Pulveratum 240g, Fructus Jujubae 2000g, Rhizoma Chuanxiong 360g, Radix Angelicae Sinensis 360g is for subsequent use;
B. above crude drug, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is for subsequent use; All the other Radix Aucklandiae of wood, Lignum Aquilariae Resinatum, Fructus Aurantii, Lignum Santali Albi, Radix Et Rhizoma Rhei, Cortex Magnoliae Officinalis medicated powder are broken into coarse powder, add 16 times of water gagings, soak 4 hours, and decocting boils distillation 8h altogether, collects volatile oil, and is with after β-CD inclusion, for subsequent use; Decocting liquid filters, and relative density 1.25-1.30 was for subsequent use when filtrate was concentrated into 60 ℃, and medicinal residues and Lignum Santali Albi coarse powder add 70% alcohol reflux 2 times, for the first time 2h; 1h filters for the second time; Merge secondary filtrate, relative density 1.20-1.25 when being concentrated into 60 ℃, drying, for subsequent use; Get Fructus Jujubae, add decocting and boil secondary, each 2h filters; Merge secondary filtrate, relative density 1.28-1.32 when being concentrated into 60 ℃, drying, for subsequent use with Semen Crotonis Pulveratum, Moschus mixing with the above-mentioned fine powder that is dried and crushed into, add appropriate amount of auxiliary materials, make 36000 capsules, and get final product.
Embodiment 17
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 150g, Lignum Aquilariae Resinatum 150g, Fructus Aurantii 150g, Lignum Santali Albi 90g, Radix Et Rhizoma Rhei 90g, Cortex Magnoliae Officinalis 150g, Moschus 4.5g, Semen Crotonis Pulveratum 60g, Fructus Jujubae 500g, Radix Paeoniae Alba 90g and Radix Angelicae Sinensis 90g are for subsequent use;
B. above crude drug, Semen Crotonis Pulveratum, Moschus are ground into respectively fine powder; All the other crude drug decoct with water 2 times, and each 2 hours, collecting decoction filtered, and is condensed into thick paste; In above-mentioned thick paste, add Semen Crotonis Pulveratum, Moschus powder, mixing, for subsequent use; Add sodium carboxymethyl cellulose, Icing Sugar, mixing, granule processed sieves, drying, and get final product.
Embodiment 18
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 150g, Lignum Aquilariae Resinatum 150g, Fructus Aurantii 150g, Lignum Santali Albi 90g, Radix Et Rhizoma Rhei 90g, Cortex Magnoliae Officinalis 150g, Moschus 4.5g, Semen Crotonis Pulveratum 60g, Fructus Jujubae 500g, Radix Paeoniae Alba 90g and Radix Angelicae Sinensis 90g are for subsequent use;
B. above crude drug, Semen Crotonis Pulveratum, Moschus are ground into respectively fine powder; All the other crude drug decoct with water 2 times, and each 2 hours, collecting decoction filtered, and is condensed into thick paste; In above-mentioned thick paste, add Semen Crotonis Pulveratum, Moschus powder, mixing, for subsequent use; Add sodium carboxymethyl cellulose, Icing Sugar, mixing, granule processed sieves, drying, and get final product.
Embodiment 19
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 150g, Lignum Aquilariae Resinatum 150g, Fructus Aurantii 150g, Lignum Santali Albi 90g, Radix Et Rhizoma Rhei 90g, Cortex Magnoliae Officinalis 150g, Moschus 4.5g, Semen Crotonis Pulveratum 60g, Fructus Jujubae 500g, Rhizoma Chuanxiong 90g, Radix Scutellariae 150g and Rhizoma Coptidis 150g are for subsequent use;
B. above crude drug, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is for subsequent use; The pulverizing such as all the other Radix Aucklandiae, Lignum Aquilariae Resinatum, Fructus Aurantii, Lignum Santali Albi, Radix Et Rhizoma Rhei, Cortex Magnoliae Officinalis, CO 2Supercritical extraction; Get extract, add an amount of anhydrous alcohol solution, carry out enclose with an amount of β-CD, drying namely gets clathrate, and is for subsequent use; With the medicinal residues ethanol extraction secondary behind the above-mentioned supercritical extraction, merge secondary filtrate, Recycled ethanol is concentrated for subsequent use; Get Fructus Jujubae and decoct with water secondary, filter; Merging filtrate, concentrated, with above-mentioned alcohol extract condensed cream mixing, drying is ground into fine powder, with clathrate, Semen Crotonis Pulveratum, the Moschus mixing that sieves, sieves again, and is for subsequent use; Add an amount of magnesium stearate, mixing, compacting, and get final product.
Embodiment 20
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 600g, Lignum Aquilariae Resinatum 600g, Fructus Aurantii 600g, Lignum Santali Albi 360g, Radix Et Rhizoma Rhei 360g, Cortex Magnoliae Officinalis 600g, Moschus 18g, Semen Crotonis Pulveratum 240g, Fructus Jujubae 2000g, Rhizoma Chuanxiong 360g, Radix Scutellariae 600g and Rhizoma Coptidis 600g are for subsequent use;
B. above crude drug, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is for subsequent use; All the other Radix Aucklandiae, Lignum Aquilariae Resinatum, Fructus Aurantii, Lignum Santali Albi, Radix Et Rhizoma Rhei, Cortex Magnoliae Officinalis etc. are ground into coarse powder, add water, soak, and decocting boils distillation, collect volatile oil, and be with after β-CD inclusion, for subsequent use; Decocting liquid filters, and filtrate is concentrated for subsequent use, and medicinal residues and Lignum Santali Albi coarse powder add alcohol reflux 2 times, filters; Merge secondary filtrate, concentrated, drying, for subsequent use; Get Fructus Jujubae, add decocting and boil secondary, filter; Merge secondary filtrate, concentrated, drying, the above-mentioned fine powder that is dried and crushed into, with Semen Crotonis Pulveratum, Moschus mixing, for subsequent use; Add an amount of magnesium stearate, mixing, compacting, and get final product.
Embodiment 21
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 250g, Lignum Aquilariae Resinatum 250g, Fructus Aurantii 250g, Lignum Santali Albi 150g, Radix Et Rhizoma Rhei 150g, Cortex Magnoliae Officinalis 250g, Moschus 6g, Semen Crotonis Pulveratum 100g, Fructus Jujubae 800g, Rhizoma Chuanxiong 150g, Radix Codonopsis 250g and Rhizoma Coptidis 150g are for subsequent use;
B. above crude drug, Semen Crotonis Pulveratum, Moschus are ground into respectively fine powder; All the other crude drug decoct with water 3 times, and each 3 hours, collecting decoction filtered, and is condensed into thick paste; In above-mentioned thick paste, add Semen Crotonis Pulveratum, Moschus powder, mixing, for subsequent use; Add the mixings such as starch, microcrystalline Cellulose, sieve, granulation adds the volatile oil such as the Radix Aucklandiae again, mixing, and drying adds an amount of magnesium stearate, mixing, compacting, and get final product.
Embodiment 22
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 400g, Lignum Aquilariae Resinatum 400g, Fructus Aurantii 400g, Lignum Santali Albi 250g, Radix Et Rhizoma Rhei 250g, Cortex Magnoliae Officinalis 400g, Moschus 12g, Semen Crotonis Pulveratum 150g, Fructus Jujubae 1200g, Rhizoma Chuanxiong 250g, Radix Codonopsis 400g and Rhizoma Coptidis 300g are for subsequent use;
B. above crude drug, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is for subsequent use; All the other Radix Aucklandiae, Lignum Aquilariae Resinatum, Fructus Aurantii, Lignum Santali Albi, Radix Et Rhizoma Rhei, Cortex Magnoliae Officinalis etc. are ground into 60 purpose powder, CO 2Supercritical extraction, extracting pressure 10MPa, temperature 50 C, CO 2Flow velocity 25L/h, extraction 3h; Get extract, add an amount of anhydrous alcohol solution, with an amount of β-CD, adopt polishing to carry out enclose, in 40 ℃ of vacuum dryings, namely get clathrate, for subsequent use; Medicinal residues behind the above-mentioned supercritical extraction are added 60% ethanol extraction secondary, merge secondary filtrate, relative density is that 1.25-1.30 is for subsequent use during Recycled ethanol to 60 ℃; Get Fructus Jujubae and decoct with water secondary, each 2h filters; Merging filtrate, relative density 1.25-1.30 when being concentrated into 60 ℃, with above-mentioned alcohol extract condensed cream mixing, drying is ground into fine powder, with clathrate, Semen Crotonis Pulveratum, the Moschus mixing that sieves, crosses 80 mesh sieves again, and is for subsequent use; Add 2 ‰ magnesium stearate, mixing, compacting is in blocks, and get final product.
Embodiment 23
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 250g, Lignum Aquilariae Resinatum 250g, Fructus Aurantii 250g, Lignum Santali Albi 150g, Radix Et Rhizoma Rhei 150g, Cortex Magnoliae Officinalis 250g, Moschus 6g, Semen Crotonis Pulveratum 100g, Fructus Jujubae 800g, Rhizoma Chuanxiong 150g, Rhizoma Atractylodis Macrocephalae 250g and Rhizoma Coptidis 150g are for subsequent use;
B. above crude drug, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is for subsequent use; All the other Radix Aucklandiae, Lignum Aquilariae Resinatum, Fructus Aurantii, Lignum Santali Albi, Radix Et Rhizoma Rhei, Cortex Magnoliae Officinalis etc. are ground into coarse powder, add 10 times of water gagings, soak 4 hours, and decocting boils distillation 8h altogether, collects volatile oil, and is with after β-CD inclusion, for subsequent use; Decocting liquid filters, and relative density 1.25-1.30 was for subsequent use when filtrate was concentrated into 60 ℃, and medicinal residues and Lignum Santali Albi coarse powder add 70% alcohol reflux 2 times, for the first time 2h; 1h filters for the second time; Merge secondary filtrate, relative density 1.20-1.25 when being concentrated into 60 ℃, drying, for subsequent use; Get Fructus Jujubae, add decocting and boil secondary, each 2h filters; Merge secondary filtrate, relative density 1.28-1.32 when being concentrated into 60 ℃, drying, with the above-mentioned fine powder that is dried and crushed into, with Semen Crotonis Pulveratum, Moschus mixing, for subsequent use; Add 12 ‰ magnesium stearate, mixing, compacting is in blocks, and get final product.
Embodiment 24
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 250g, Lignum Aquilariae Resinatum 400g, Fructus Aurantii 400g, Lignum Santali Albi 250g, Radix Et Rhizoma Rhei 250g, Cortex Magnoliae Officinalis 400g, Moschus 12g, Semen Crotonis Pulveratum 150g, Fructus Jujubae 1200g, Rhizoma Chuanxiong 250g, Rhizoma Atractylodis Macrocephalae 400g and Rhizoma Coptidis 300g are for subsequent use;
B. above crude drug, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is for subsequent use; All the other Radix Aucklandiae, Lignum Aquilariae Resinatum, Fructus Aurantii, Lignum Santali Albi, Radix Et Rhizoma Rhei, Cortex Magnoliae Officinalis etc. are ground into coarse powder, add 16 times of water gagings, soak 4 hours, and decocting boils distillation 8h altogether, collects volatile oil, and is with after β-CD inclusion, for subsequent use; Decocting liquid filters, and relative density 1.25-1.30 was for subsequent use when filtrate was concentrated into 60 ℃, and medicinal residues and Lignum Santali Albi coarse powder add 70% alcohol reflux 2 times, for the first time 2h; 1h filters for the second time; Merge secondary filtrate, relative density 1.20-1.25 when being concentrated into 60 ℃, drying, for subsequent use; Get Fructus Jujubae, add decocting and boil secondary, each 2h filters; Merge secondary filtrate, relative density 1.28-1.32 when being concentrated into 60 ℃, drying, with the above-mentioned fine powder that is dried and crushed into, with Semen Crotonis Pulveratum, Moschus mixing, for subsequent use; Add 6 ‰ magnesium stearate, mixing is pressed into 33000, and get final product.
Embodiment 25
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 250g, Lignum Aquilariae Resinatum 250g, Fructus Aurantii 250g, Lignum Santali Albi 150g, Radix Et Rhizoma Rhei 150g, Cortex Magnoliae Officinalis 250g, Moschus 6g, Semen Crotonis Pulveratum 100g, Fructus Jujubae 800g, Rhizoma Chuanxiong 150g, Radix Codonopsis 250g, Poria 250g, Rhizoma Atractylodis Macrocephalae 250g and Rhizoma Coptidis 150g are for subsequent use;
B. above crude drug, Semen Crotonis Pulveratum, Moschus are ground into respectively fine powder; All the other crude drug decoct with water 2 times, and each 2 hours, collecting decoction filtered, and is condensed into thick paste; In above-mentioned thick paste, add Semen Crotonis Pulveratum, Moschus powder, mixing, for subsequent use; It is an amount of to add vegetable oil, and mixing is made soft capsule, and get final product.
Embodiment 26
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 400g, Lignum Aquilariae Resinatum 400g, Fructus Aurantii 400g, Lignum Santali Albi 250g, Radix Et Rhizoma Rhei 250g, Cortex Magnoliae Officinalis 400g, Moschus 12g, Semen Crotonis Pulveratum 150g, Fructus Jujubae 1200g, Rhizoma Chuanxiong 250g, Radix Codonopsis 400g, Poria 400g, Rhizoma Atractylodis Macrocephalae 400g and Rhizoma Coptidis 300g are for subsequent use;
B. above crude drug, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is for subsequent use; All the other Radix Aucklandiae, Lignum Aquilariae Resinatum, Fructus Aurantii, Lignum Santali Albi, Radix Et Rhizoma Rhei, Cortex Magnoliae Officinalis etc. are ground into coarse powder, add 12 times of water gagings, soak 4 hours, and decocting boils distillation 8h altogether, collects volatile oil, and is with after β-CD inclusion, for subsequent use; Decocting liquid filters, and relative density 1.25-1.30 was for subsequent use when filtrate was concentrated into 60 ℃, and medicinal residues and Lignum Santali Albi coarse powder add 70% alcohol reflux 2 times, for the first time 2h; 1h filters for the second time; Merge secondary filtrate, relative density 1.20-1.25 when being concentrated into 60 ℃, drying, for subsequent use; Get Fructus Jujubae, add decocting and boil secondary, each 2h filters; Merge secondary filtrate, relative density 1.28-1.32 when being concentrated into 60 ℃, drying, with the above-mentioned fine powder that is dried and crushed into, with Semen Crotonis Pulveratum, Moschus mixing, for subsequent use; It is an amount of to add vegetable oil, and mixing is made soft capsule, and get final product.
Embodiment 27
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 250g, Lignum Aquilariae Resinatum 250g, Fructus Aurantii 250g, Lignum Santali Albi 150g, Radix Et Rhizoma Rhei 150g, Cortex Magnoliae Officinalis 250g, Moschus 6g, Semen Crotonis Pulveratum 100g, Rhizoma Chuanxiong 150g, Seem Lablab Album 250g and Rhizoma Dioscoreae 250g are for subsequent use;
B. above crude drug, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is for subsequent use; All the other Radix Aucklandiae, Lignum Aquilariae Resinatum, Fructus Aurantii, Lignum Santali Albi, Radix Et Rhizoma Rhei, Cortex Magnoliae Officinalis etc. are ground into 50 purpose powder, CO 2Supercritical extraction, extracting pressure 17MPa, 40 ℃ of temperature, CO 2Flow velocity 25L/h, extraction 3h; Get extract, add an amount of anhydrous alcohol solution, with an amount of β-CD, adopt polishing to carry out enclose, in 40 ℃ of vacuum dryings, namely get clathrate, for subsequent use; Medicinal residues behind the above-mentioned supercritical extraction are added 60% ethanol extraction secondary, merge secondary filtrate, relative density is that 1.25-1.30 is for subsequent use during Recycled ethanol to 60 ℃; Clathrate, Semen Crotonis Pulveratum, the Moschus mixing that sieves is crossed 80 mesh sieves, and is for subsequent use; It is an amount of to add vegetable oil, makes 36000 soft capsules, and get final product.
Embodiment 28
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 400g, Lignum Aquilariae Resinatum 400g, Fructus Aurantii 400g, Lignum Santali Albi 250g, Radix Et Rhizoma Rhei 250g, Cortex Magnoliae Officinalis 400g, Moschus 12g, Semen Crotonis Pulveratum 150g, Rhizoma Chuanxiong 250g, Seem Lablab Album 400g and Rhizoma Dioscoreae 400g are for subsequent use;
B. above crude drug, Semen Crotonis Pulveratum, Moschus are ground into respectively fine powder; All the other crude drug decoct with water 2 times, and each 2 hours, collecting decoction filtered, and is condensed into thick paste; In above-mentioned thick paste, add Semen Crotonis Pulveratum, Moschus powder, mixing, for subsequent use; It is an amount of to add vegetable oil, and mixing is made soft capsule, and get final product.
Embodiment 29
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 250g, Lignum Aquilariae Resinatum 250g, Fructus Aurantii 250g, Lignum Santali Albi 150g, Radix Et Rhizoma Rhei 150g, Cortex Magnoliae Officinalis 250g, Moschus 6g, Semen Crotonis Pulveratum 100g, Fructus Jujubae 800g, Rhizoma Chuanxiong 150～250g, Semen Arecae 120g and Fructus Crataegi 250g are for subsequent use;
B. Semen Crotonis Pulveratum, Moschus are ground into respectively fine powder; All the other Radix Aucklandiae, Lignum Aquilariae Resinatum, Fructus Aurantii, Lignum Santali Albi, Radix Et Rhizoma Rhei, Cortex Magnoliae Officinalis etc. are ground into fine powder; With Semen Crotonis Pulveratum, Moschus powder facing-up, mixing sieves; Get above-mentioned hybrid medicine powder 569g, add glycerol 6000g, Al (OH) 380g, sodium acrylate 1500g mix homogeneously are component A; Get tartaric acid 40g, add distilled water 13500g, acrylate copolymer 800g, dissolving is B component; B component slowly adds among the component A, stirs, and coating, compound with protecting film, cut and get final product.
Embodiment 30
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 400g, Lignum Aquilariae Resinatum 400g, Fructus Aurantii 400g, Lignum Santali Albi 250g, Radix Et Rhizoma Rhei 250g, Cortex Magnoliae Officinalis 400g, Moschus 12g, Semen Crotonis Pulveratum 150g, Fructus Jujubae 1200g, Rhizoma Chuanxiong 250g, Semen Arecae 250g and Fructus Crataegi 400g are for subsequent use;
B. above crude drug, Semen Crotonis Pulveratum, Moschus are ground into respectively fine powder; All the other crude drug decoct with water 2 times, and each 2 hours, collecting decoction filters, and is condensed into thick paste, and was for subsequent use; Taking polyethylene glycol 6000: the mixture Polyethylene Glycol of Macrogol 4000=3: 2 is an amount of, and heating makes melting, adds above-mentioned thick paste and Semen Crotonis Pulveratum, Moschus powder, mixing, adopt dripping speed is 50～60/min, splashes into methyl-silicone oil: in the condensed fluid of liquid Paraffin=4: 1, namely get drop pill, and get final product.
Embodiment 31
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 250g, Lignum Aquilariae Resinatum 250g, Fructus Aurantii 250g, Lignum Santali Albi 150～g, Radix Et Rhizoma Rhei 150g, Cortex Magnoliae Officinalis 250g, Moschus 6g, Semen Crotonis Pulveratum 100g, Fructus Jujubae 800g, Rhizoma Chuanxiong 150g, Poria 250g and JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata) 250g are for subsequent use;
B. above crude drug, Semen Crotonis Pulveratum, Moschus are ground into respectively fine powder; All the other crude drug decoct with water 2 times, and each 2 hours, collecting decoction filters, and is condensed into thick paste, and was for subsequent use; Taking polyethylene glycol 6000: the mixture Polyethylene Glycol of Macrogol 4000=5: 2 is an amount of, and heating makes melting, adds above-mentioned thick paste and Semen Crotonis Pulveratum, Moschus powder, mixing, adopt dripping speed is 55～60/min, splashes into methyl-silicone oil: in the condensed fluid of liquid Paraffin=3: 1, namely get drop pill, and get final product.
Embodiment 32
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 400g, Lignum Aquilariae Resinatum 400g, Fructus Aurantii 400g, Lignum Santali Albi 250g, Radix Et Rhizoma Rhei 250g, Cortex Magnoliae Officinalis 400g, Moschus 12g, Semen Crotonis Pulveratum 150g, Fructus Jujubae 1200g, Rhizoma Chuanxiong 250g, Poria 400g and JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata) 400g are for subsequent use;
B. above crude drug, Semen Crotonis Pulveratum, Moschus are ground into respectively fine powder; All the other eight flavor medicines decoct with water 2 times, and each 2 hours, collecting decoction filtered, and is condensed into thick paste; In above-mentioned thick paste, add Semen Crotonis Pulveratum, Moschus powder, mixing, for subsequent use; Get above-mentioned hybrid medicine powder 1800g, add glycerol 8000g, Al (OH) 345g, sodium acrylate 2000g mix homogeneously are component A; Get tartaric acid 90g, add distilled water 27000g, acrylate copolymer 1800g, dissolving is B component; B component slowly adds among the component A, stirs, and coating, compound with protecting film, cut and get final product.
Embodiment 33
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 250g, Lignum Aquilariae Resinatum 250g, Fructus Aurantii 250g, Lignum Santali Albi 150g, Radix Et Rhizoma Rhei 150g, Cortex Magnoliae Officinalis 250g, Moschus 6g, Semen Crotonis Pulveratum 100g, Fructus Jujubae 800g, Rhizoma Chuanxiong 150g, Endothelium Corneum Gigeriae Galli 120g, JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata) 250g and Pericarpium Citri Reticulatae 150g are for subsequent use;
B. above crude drug, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is for subsequent use; The pulverizing such as all the other Radix Aucklandiae, Lignum Aquilariae Resinatum, Fructus Aurantii, Lignum Santali Albi, Radix Et Rhizoma Rhei, Cortex Magnoliae Officinalis, CO 2Supercritical extraction; Get extract, add an amount of anhydrous alcohol solution, carry out enclose with an amount of β-CD, drying namely gets clathrate, and is for subsequent use; With the medicinal residues ethanol extraction secondary behind the above-mentioned supercritical extraction, merge secondary filtrate, Recycled ethanol is concentrated for subsequent use; Get Fructus Jujubae and decoct with water secondary, filter; Merging filtrate, concentrated, with above-mentioned alcohol extract condensed cream mixing, drying is ground into fine powder, with clathrate, Semen Crotonis Pulveratum, the Moschus mixing that sieves, sieves again, and is for subsequent use, encapsulated, and get final product.
Embodiment 34
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 400g, Lignum Aquilariae Resinatum 400g, Fructus Aurantii 400g, Lignum Santali Albi 250g, Radix Et Rhizoma Rhei 250g, Cortex Magnoliae Officinalis 400g, Moschus 12g, Semen Crotonis Pulveratum 150g, Fructus Jujubae 1200g, Rhizoma Chuanxiong 250g, Endothelium Corneum Gigeriae Galli 50g, JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata) 400g and Pericarpium Citri Reticulatae 150～600g are for subsequent use;
B. above crude drug, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is for subsequent use; The pulverizing such as all the other Radix Aucklandiae, Lignum Aquilariae Resinatum, Fructus Aurantii, Lignum Santali Albi, Radix Et Rhizoma Rhei, Cortex Magnoliae Officinalis, CO 2Supercritical extraction; Get extract, add an amount of anhydrous alcohol solution, carry out enclose with an amount of β-CD, drying namely gets clathrate, and is for subsequent use; With the medicinal residues ethanol extraction secondary behind the above-mentioned supercritical extraction, merge secondary filtrate, Recycled ethanol is concentrated for subsequent use; Get Fructus Jujubae and decoct with water secondary, filter; Merging filtrate, concentrated, with above-mentioned alcohol extract condensed cream mixing, drying is ground into fine powder, with clathrate, Semen Crotonis Pulveratum, the Moschus mixing that sieves, sieves again, and is for subsequent use, encapsulated, and get final product.
Embodiment 35
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 250g, Lignum Aquilariae Resinatum 250g, Fructus Aurantii 250g, Lignum Santali Albi 150g, Radix Et Rhizoma Rhei 150g, Cortex Magnoliae Officinalis 250g, Moschus 6g, Semen Crotonis Pulveratum 100g, Fructus Jujubae 800g, Rhizoma Chuanxiong 150g, Radix Angelicae Sinensis 120g is for subsequent use; B. above crude drug, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is for subsequent use; The pulverizing such as all the other Radix Aucklandiae, Lignum Aquilariae Resinatum, Fructus Aurantii, Lignum Santali Albi, Radix Et Rhizoma Rhei, Cortex Magnoliae Officinalis, CO 2Supercritical extraction; Get extract, add an amount of anhydrous alcohol solution, carry out enclose with an amount of β-CD, drying namely gets clathrate, and is for subsequent use; With the medicinal residues ethanol extraction secondary behind the above-mentioned supercritical extraction, merge secondary filtrate, Recycled ethanol is concentrated for subsequent use; Get Fructus Jujubae and decoct with water secondary, filter; Merging filtrate, concentrated, with above-mentioned alcohol extract condensed cream mixing, drying is ground into fine powder, with clathrate, Semen Crotonis Pulveratum, the Moschus mixing that sieves, sieves again, and is for subsequent use, encapsulated, and get final product.
Embodiment 36
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 400g, Lignum Aquilariae Resinatum 400g, Fructus Aurantii 400g, Lignum Santali Albi 250g, Radix Et Rhizoma Rhei 250g, Cortex Magnoliae Officinalis 400g, Moschus 12g, Semen Crotonis Pulveratum 150g, Fructus Jujubae 1200g, Rhizoma Chuanxiong 250g, Radix Angelicae Sinensis 250g is for subsequent use;
B. above crude drug, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is for subsequent use; The pulverizing such as all the other Radix Aucklandiae, Lignum Aquilariae Resinatum, Fructus Aurantii, Lignum Santali Albi, Radix Et Rhizoma Rhei, Cortex Magnoliae Officinalis, CO 2Supercritical extraction; Get extract, add an amount of anhydrous alcohol solution, carry out enclose with an amount of β-CD, drying namely gets clathrate, and is for subsequent use; With the medicinal residues ethanol extraction secondary behind the above-mentioned supercritical extraction, merge secondary filtrate, Recycled ethanol is concentrated for subsequent use; Get Fructus Jujubae and decoct with water secondary, filter; Merging filtrate, concentrated, with above-mentioned alcohol extract condensed cream mixing, drying is ground into fine powder, with clathrate, Semen Crotonis Pulveratum, the Moschus mixing that sieves, sieves again, and is for subsequent use, encapsulated, and get final product.
Embodiment 37
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 250g, Lignum Aquilariae Resinatum 250g, Fructus Aurantii 250g, Lignum Santali Albi 150g, Radix Et Rhizoma Rhei 150g, Cortex Magnoliae Officinalis 250g, Moschus 6g, Semen Crotonis Pulveratum 100g, Fructus Jujubae 800g, Radix Paeoniae Alba 120g and Rhizoma Chuanxiong 150g are for subsequent use;
B. above crude drug, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is for subsequent use; All the other Radix Aucklandiae, Lignum Aquilariae Resinatum, Fructus Aurantii, Lignum Santali Albi, Radix Et Rhizoma Rhei, Cortex Magnoliae Officinalis etc. are ground into coarse powder, add 16 times of water gagings, soak 4 hours, and decocting boils distillation 8h altogether, collects volatile oil, and is with after β-CD inclusion, for subsequent use; Decocting liquid filters, and relative density 1.25-1.30 was for subsequent use when filtrate was concentrated into 60 ℃, and medicinal residues and Lignum Santali Albi coarse powder add 70% alcohol reflux 2 times, for the first time 2h; 1h filters for the second time; Merge secondary filtrate, relative density 1.20-1.25 when being concentrated into 60 ℃, drying, for subsequent use; Get Fructus Jujubae, add decocting and boil secondary, each 2h filters; Merge secondary filtrate, relative density 1.28-1.32 when being concentrated into 60 ℃, drying, with the above-mentioned fine powder that is dried and crushed into, with Semen Crotonis Pulveratum, Moschus mixing, for subsequent use; Get carbomer 88g, add water 10000g and stir, NaOH regulates pH to 7, adds above-mentioned hybrid medicine powder 2500g, grinds evenly, and get final product.
Embodiment 38
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 400g, Lignum Aquilariae Resinatum 400g, Fructus Aurantii 400g, Lignum Santali Albi 250g, Radix Et Rhizoma Rhei 250g, Cortex Magnoliae Officinalis 400g, Moschus 12g, Semen Crotonis Pulveratum 150g, Fructus Jujubae 1200g, Radix Paeoniae Alba 250g and Rhizoma Chuanxiong 250g are for subsequent use;
B. above crude drug, Semen Crotonis Pulveratum, Moschus are ground into respectively fine powder; All the other crude drug decoct with water 2 times, and each 2 hours, collecting decoction filtered, and is condensed into thick paste; In above-mentioned thick paste, add Semen Crotonis Pulveratum, Moschus powder, mixing, for subsequent use; Get carbomer 85g, add water 7500g and stir, NaOH regulates pH to 7, adds above-mentioned hybrid medicine powder 2059g, grinds evenly, and get final product.
Embodiment 39
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 250g, Lignum Aquilariae Resinatum 250g, Fructus Aurantii 250g, Lignum Santali Albi 150g, Radix Et Rhizoma Rhei 150g, Cortex Magnoliae Officinalis 250g, Moschus 6g, Semen Crotonis Pulveratum 100g, Fructus Jujubae 800g, Rhizoma Chuanxiong 150g, Radix Scutellariae 250g and Rhizoma Coptidis 250g are for subsequent use;
B. above crude drug, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is for subsequent use; All the other Radix Aucklandiae, Lignum Aquilariae Resinatum, Fructus Aurantii, Lignum Santali Albi, Radix Et Rhizoma Rhei, Cortex Magnoliae Officinalis etc. are ground into 50 purpose powder, CO 2Supercritical extraction, extracting pressure 20MPa, 55 ℃ of temperature, CO 2Flow velocity 25L/h, extraction 3h; Get extract, add an amount of anhydrous alcohol solution, with an amount of β-CD, adopt polishing to carry out enclose, in 40 ℃ of vacuum dryings, namely get clathrate, for subsequent use; Medicinal residues behind the above-mentioned supercritical extraction are added 60% ethanol extraction secondary, merge secondary filtrate, relative density is that 1.25-1.30 is for subsequent use during Recycled ethanol to 60 ℃; Get Fructus Jujubae and decoct with water secondary, each 2h filters; Merging filtrate, relative density 1.25-1.30 when being concentrated into 60 ℃, with above-mentioned alcohol extract condensed cream mixing, drying is ground into fine powder, with clathrate, Semen Crotonis Pulveratum, the Moschus mixing that sieves, crosses 80 mesh sieves again, and is for subsequent use; Get carbomer 188g, add water 14000g and stir, NaOH regulates pH to 7, adds above-mentioned hybrid medicine powder 1800g, grinds evenly, and get final product.
Embodiment 40
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 400g, Lignum Aquilariae Resinatum 400g, Fructus Aurantii 400g, Lignum Santali Albi 250g, Radix Et Rhizoma Rhei 250g, Cortex Magnoliae Officinalis 400g, Moschus 12g, Semen Crotonis Pulveratum 150g, Fructus Jujubae 1200g, Rhizoma Chuanxiong 250g, Radix Scutellariae 400g and Rhizoma Coptidis 400g are for subsequent use;
B. above crude drug, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is for subsequent use; All the other Radix Aucklandiae, Lignum Aquilariae Resinatum, Fructus Aurantii, Lignum Santali Albi, Radix Et Rhizoma Rhei, Cortex Magnoliae Officinalis etc. are ground into 40-80 purpose powder, CO 2Supercritical extraction, extracting pressure 15MPa, 40 ℃ of temperature, CO 2Flow velocity 22L/h, extraction 2.5h; Get extract, add an amount of anhydrous alcohol solution, with an amount of β-CD, adopt polishing to carry out enclose, in 40 ℃ of vacuum dryings, namely get clathrate, for subsequent use; Medicinal residues behind the above-mentioned supercritical extraction are added 60% ethanol extraction secondary, merge secondary filtrate, relative density is that 1.25-1.30 is for subsequent use during Recycled ethanol to 60 ℃; Get Fructus Jujubae and decoct with water secondary, each 2h filters; Merging filtrate, relative density 1.25-1.30 when being concentrated into 60 ℃, with above-mentioned alcohol extract condensed cream mixing, drying is ground into fine powder, with clathrate, Semen Crotonis Pulveratum, the Moschus mixing that sieves, crosses 80 mesh sieves again, and is for subsequent use; Get above-mentioned hybrid medicine powder 1000g, fat-soluble ointment base 4000g is heated to 60 ℃ of mix homogeneously, is stirred to room temperature, and get final product.
Embodiment 41
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 300g, Lignum Aquilariae Resinatum 300g, Fructus Aurantii 300g, Lignum Santali Albi 180g, Radix Et Rhizoma Rhei 180g, Cortex Magnoliae Officinalis 300g, Moschus 9g, Semen Crotonis Pulveratum 120g, Fructus Jujubae 1000g, Rhizoma Chuanxiong 180g, Radix Codonopsis 300g and Rhizoma Coptidis 200g are for subsequent use;
B. above crude drug, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is for subsequent use; The pulverizing such as all the other Radix Aucklandiae, Lignum Aquilariae Resinatum, Fructus Aurantii, Lignum Santali Albi, Radix Et Rhizoma Rhei, Cortex Magnoliae Officinalis, CO 2Supercritical extraction; Get extract, add an amount of anhydrous alcohol solution, carry out enclose with an amount of β-CD, drying namely gets clathrate, and is for subsequent use; With the medicinal residues ethanol extraction secondary behind the above-mentioned supercritical extraction, merge secondary filtrate, Recycled ethanol is concentrated for subsequent use; Get Fructus Jujubae and decoct with water secondary, filter; Merging filtrate, concentrated, with above-mentioned alcohol extract condensed cream mixing, drying is ground into fine powder, with clathrate, Semen Crotonis Pulveratum, the Moschus mixing that sieves, sieves again, and is for subsequent use, encapsulated, and get final product.
Embodiment 42
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 300g, Lignum Aquilariae Resinatum 300g, Fructus Aurantii 300g, Lignum Santali Albi 180g, Radix Et Rhizoma Rhei 180g, Cortex Magnoliae Officinalis 300g, Moschus 9g, Semen Crotonis Pulveratum 120g, Fructus Jujubae 1000g, Rhizoma Chuanxiong 180g, Rhizoma Atractylodis Macrocephalae 300g and Rhizoma Coptidis 200g are for subsequent use;
B. above crude drug, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is for subsequent use; All the other Radix Aucklandiae, Lignum Aquilariae Resinatum, Fructus Aurantii, Lignum Santali Albi, Radix Et Rhizoma Rhei, Cortex Magnoliae Officinalis etc. are ground into coarse powder, add water, soak, and decocting boils distillation, collect volatile oil, and be with after β-CD inclusion, for subsequent use; Decocting liquid filters, and filtrate is concentrated for subsequent use, and medicinal residues and Lignum Santali Albi coarse powder add alcohol reflux 2 times, filters; Merge secondary filtrate, concentrated, drying, for subsequent use; Get Fructus Jujubae, add decocting and boil secondary, filter; Merge secondary filtrate, concentrated, drying, the above-mentioned fine powder that is dried and crushed into, for subsequent use, encapsulated with Semen Crotonis Pulveratum, Moschus mixing, and get final product.
Embodiment 43
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 300g, Lignum Aquilariae Resinatum 300g, Fructus Aurantii 300g, Lignum Santali Albi 180g, Radix Et Rhizoma Rhei 180g, Cortex Magnoliae Officinalis 300g, Moschus 9g, Semen Crotonis Pulveratum 120g, Fructus Jujubae 1000g, Rhizoma Chuanxiong 180g, Radix Codonopsis 300g, Poria 300g, Rhizoma Atractylodis Macrocephalae 300g and Rhizoma Coptidis 200g are for subsequent use;
B. above crude drug, Semen Crotonis Pulveratum, Moschus are ground into respectively fine powder; All the other crude drug decoct with water 3 times, and each 1 hour, collecting decoction filtered, and is condensed into thick paste; In above-mentioned thick paste, add Semen Crotonis Pulveratum, Moschus powder, mixing, for subsequent use, encapsulated, and get final product.
Embodiment 44
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 300g, Lignum Aquilariae Resinatum 300g, Fructus Aurantii 300g, Lignum Santali Albi 180g, Radix Et Rhizoma Rhei 180g, Cortex Magnoliae Officinalis 300g, Moschus 9g, Semen Crotonis Pulveratum 120g, Rhizoma Chuanxiong 180g, Seem Lablab Album 300g and Rhizoma Dioscoreae 300g are for subsequent use;
B. go up ten flavors, Semen Crotonis Pulveratum, Moschus are ground into respectively fine powder; All the other crude drug decoct with water 2 times, and each 3 hours, collecting decoction filtered, and is condensed into thick paste; In above-mentioned thick paste, add Semen Crotonis Pulveratum, Moschus powder, mixing, for subsequent use; Encapsulated, and get final product.
Embodiment 45
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 300g, Lignum Aquilariae Resinatum 300g, Fructus Aurantii 300g, Lignum Santali Albi 180g, Radix Et Rhizoma Rhei 180g, Cortex Magnoliae Officinalis 300g, Moschus 9g, Semen Crotonis Pulveratum 120g, Fructus Jujubae 1000g, Rhizoma Chuanxiong 180g, Semen Arecae 180g and Fructus Crataegi 300g are for subsequent use;
B. above crude drug, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is for subsequent use; All the other Radix Aucklandiae, Lignum Aquilariae Resinatum, Fructus Aurantii, Lignum Santali Albi, Radix Et Rhizoma Rhei, Cortex Magnoliae Officinalis etc. are ground into 80 purpose powder, CO 2Supercritical extraction, extracting pressure 40MPa, temperature 60 C, CO 2Flow velocity 35L/h, extraction 5h; Get extract, add an amount of anhydrous alcohol solution, with an amount of β-CD, adopt polishing to carry out enclose, in 40 ℃ of vacuum dryings, namely get clathrate, for subsequent use; Medicinal residues behind the above-mentioned supercritical extraction are added 60% ethanol extraction secondary, merge secondary filtrate, relative density is that 1.25-1.30 is for subsequent use during Recycled ethanol to 60 ℃; Get Fructus Jujubae and decoct with water secondary, each 2h filters; Merging filtrate, relative density 1.25-1.30 when being concentrated into 60 ℃, with above-mentioned alcohol extract condensed cream mixing, drying is ground into fine powder, with clathrate, Semen Crotonis Pulveratum, the Moschus mixing that sieves, crosses 80 mesh sieves again, and is for subsequent use; Encapsulated, and get final product.
Embodiment 46
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 300g, Lignum Aquilariae Resinatum 300g, Fructus Aurantii 300g, Lignum Santali Albi 180g, Radix Et Rhizoma Rhei 180g, Cortex Magnoliae Officinalis 300g, Moschus 9g, Semen Crotonis Pulveratum 120g, Fructus Jujubae 1000g, Rhizoma Chuanxiong 180g, Poria 300g and JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata) 300g are for subsequent use;
B. above crude drug, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is for subsequent use; All the other Radix Aucklandiae, Lignum Aquilariae Resinatum, Fructus Aurantii, Lignum Santali Albi, Radix Et Rhizoma Rhei, Cortex Magnoliae Officinalis etc. are ground into coarse powder, add 16 times of water gagings, soak 4 hours, and decocting boils distillation 8h altogether, collects volatile oil, and is with after β-CD inclusion, for subsequent use; Decocting liquid filters, and relative density 1.25-1.30 was for subsequent use when filtrate was concentrated into 60 ℃, and medicinal residues and Lignum Santali Albi coarse powder add 70% alcohol reflux 2 times, for the first time 2h; 1h filters for the second time; Merge secondary filtrate, relative density 1.20-1.25 when being concentrated into 60 ℃, drying, for subsequent use; Get Fructus Jujubae, add decocting and boil secondary, each 2h filters; Merge secondary filtrate, relative density 1.28-1.32 when being concentrated into 60 ℃, drying, for subsequent use with Semen Crotonis Pulveratum, Moschus mixing with the above-mentioned fine powder that is dried and crushed into, add appropriate amount of auxiliary materials, make 36000 capsules, and get final product.
Embodiment 47
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 300g, Lignum Aquilariae Resinatum 300g, Fructus Aurantii 300g, Lignum Santali Albi 180g, Radix Et Rhizoma Rhei 180g, Cortex Magnoliae Officinalis 300g, Moschus 9g, Semen Crotonis Pulveratum 120g, Fructus Jujubae 1000g, Rhizoma Chuanxiong 180g, Endothelium Corneum Gigeriae Galli 180g, JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata) 300g and Pericarpium Citri Reticulatae 300g are for subsequent use;
B. above crude drug, Semen Crotonis Pulveratum, Moschus are ground into respectively fine powder; All the other crude drug decoct with water 2 times, and each 2 hours, collecting decoction filtered, and is condensed into thick paste; In above-mentioned thick paste, add Semen Crotonis Pulveratum, Moschus powder, mixing, for subsequent use; Add sodium carboxymethyl cellulose, Icing Sugar, mixing, granule processed sieves, drying, and get final product.
Embodiment 48
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 300g, Lignum Aquilariae Resinatum 300g, Fructus Aurantii 300g, Lignum Santali Albi 180g, Radix Et Rhizoma Rhei 180g, Cortex Magnoliae Officinalis 300g, Moschus 9g, Semen Crotonis Pulveratum 120g, Fructus Jujubae 1000g, Rhizoma Chuanxiong 180g, Radix Angelicae Sinensis 180g is for subsequent use;
B. above crude drug, Semen Crotonis Pulveratum, Moschus are ground into respectively fine powder; All the other crude drug decoct with water 2 times, and each 2 hours, collecting decoction filtered, and is condensed into thick paste; In above-mentioned thick paste, add Semen Crotonis Pulveratum, Moschus powder, mixing, for subsequent use; Add sodium carboxymethyl cellulose, Icing Sugar, mixing, granule processed sieves, drying, and get final product.
Embodiment 49
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 300g, Lignum Aquilariae Resinatum 300g, Fructus Aurantii 300g, Lignum Santali Albi 180g, Radix Et Rhizoma Rhei 180g, Cortex Magnoliae Officinalis 300g, Moschus 9g, Semen Crotonis Pulveratum 120g, Fructus Jujubae 1000g, Radix Paeoniae Alba 180g and Rhizoma Chuanxiong 180g are for subsequent use;
B. above crude drug, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is for subsequent use; The pulverizing such as all the other Radix Aucklandiae, Lignum Aquilariae Resinatum, Fructus Aurantii, Lignum Santali Albi, Radix Et Rhizoma Rhei, Cortex Magnoliae Officinalis, CO 2Supercritical extraction; Get extract, add an amount of anhydrous alcohol solution, carry out enclose with an amount of β-CD, drying namely gets clathrate, and is for subsequent use; With the medicinal residues ethanol extraction secondary behind the above-mentioned supercritical extraction, merge secondary filtrate, Recycled ethanol is concentrated for subsequent use; Get Fructus Jujubae and decoct with water secondary, filter; Merging filtrate, concentrated, with above-mentioned alcohol extract condensed cream mixing, drying is ground into fine powder, with clathrate, Semen Crotonis Pulveratum, the Moschus mixing that sieves, sieves again, and is for subsequent use; Add an amount of magnesium stearate, mixing, compacting, and get final product.
Embodiment 50
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 300g, Lignum Aquilariae Resinatum 300g, Fructus Aurantii 300g, Lignum Santali Albi 180g, Radix Et Rhizoma Rhei 180g, Cortex Magnoliae Officinalis 300g, Moschus 9g, Semen Crotonis Pulveratum 120g, Fructus Jujubae 1000g, Rhizoma Chuanxiong 180g, Radix Scutellariae 300g and Rhizoma Coptidis 300g are for subsequent use;
B. above crude drug, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is for subsequent use; All the other Radix Aucklandiae, Lignum Aquilariae Resinatum, Fructus Aurantii, Lignum Santali Albi, Radix Et Rhizoma Rhei, Cortex Magnoliae Officinalis etc. are ground into coarse powder, add water, soak, and decocting boils distillation, collect volatile oil, and be with after β-CD inclusion, for subsequent use; Decocting liquid filters, and filtrate is concentrated for subsequent use, and medicinal residues and Lignum Santali Albi coarse powder add alcohol reflux 2 times, filters; Merge secondary filtrate, concentrated, drying, for subsequent use; Get Fructus Jujubae, add decocting and boil secondary, filter; Merge secondary filtrate, concentrated, drying, the above-mentioned fine powder that is dried and crushed into, with Semen Crotonis Pulveratum, Moschus mixing, for subsequent use; Add an amount of magnesium stearate, mixing, compacting, and get final product.

Claims (10)

1. treatment gastrointestinal disease Chinese medicine composition is characterized in that, is to be made by following weight proportioning crude drug:
The Radix Aucklandiae 150～600g, Lignum Aquilariae Resinatum 150～600g, Fructus Aurantii 150～600g, Lignum Santali Albi 90～360g, Radix Et Rhizoma Rhei 90～360g, Cortex Magnoliae Officinalis 150～600g, Moschus 4.5～18g, Semen Crotonis Pulveratum 60～240g, Fructus Jujubae 500～2000g, Rhizoma Chuanxiong 90～360g, Radix Codonopsis 150～600g, Poria 150～600g, the Rhizoma Atractylodis Macrocephalae 150～600g and Rhizoma Coptidis 100～400g.
2. the described treatment gastrointestinal disease of claim 1 Chinese medicine composition is characterized in that, is by making according to following weight proportioning crude drug: the Radix Aucklandiae 250～400g, Lignum Aquilariae Resinatum 250～400g, Fructus Aurantii 250～400g, Lignum Santali Albi 150～250g, Radix Et Rhizoma Rhei 150～250g, Cortex Magnoliae Officinalis 250～400g, Moschus 6～12g, Semen Crotonis Pulveratum 100～150g, Fructus Jujubae 800～1200g, Rhizoma Chuanxiong 150～250g, Radix Codonopsis 250～400g, Poria 250～400g, the Rhizoma Atractylodis Macrocephalae 250～400g and Rhizoma Coptidis 150～300g.
3. the described treatment gastrointestinal disease of claim 2 Chinese medicine composition is by making according to following weight proportioning crude drug:
Radix Aucklandiae 300g, Lignum Aquilariae Resinatum 300g, Fructus Aurantii 300g, Lignum Santali Albi 180g, Radix Et Rhizoma Rhei 180g, Cortex Magnoliae Officinalis 300g, Moschus 9g, Semen Crotonis Pulveratum 120g, Fructus Jujubae 1000g, Rhizoma Chuanxiong 180g, Radix Codonopsis 300g, Poria 300g, Rhizoma Atractylodis Macrocephalae 300g and Rhizoma Coptidis 200g.
4. the arbitrary described treatment gastrointestinal disease Chinese medicine composition of claim 1～3 is characterized in that Fructus Aurantii is stir-baked Fructus Aurantii in bran; Cortex Magnoliae Officinalis is Cortex Magnoliae Officinalis (processed with ginger); Fructus Jujubae is the Fructus Jujubae of enucleation.
5. the preparation method of the arbitrary described treatment gastrointestinal disease Chinese medicine composition of claim 1～3 is characterized in that:
A. getting the weight proportion crude drug, to prepare active component according to present conventional preparation method for subsequent use;
B. the active component that obtains is made preparation.
6. the preparation method of the described treatment gastrointestinal disease of claim 5 Chinese medicine composition, it is characterized in that: the preparation among the step b is tablet, granule, honey pill agent, watered pill, drop pill, hard capsule, soft capsule, patch, cataplasma, ointment, gel.
7. the application of the arbitrary described treatment gastrointestinal disease Chinese medicine composition of claim 1～3 in preparation treatment irritable bowel syndrome medicine.
8. the application of the arbitrary described treatment gastrointestinal disease Chinese medicine composition of claim 1～3 in preparation treatment acute diarrhea, bacillary dysentery, enteritis, lienteric diarrhea medicine.
9. the arbitrary described treatment gastrointestinal disease Chinese medicine composition of claim 1～3 is in preparation eliminating turbid pathogen with aromatics, regulating QI to relieve pain, the application in the consumer product dredge stasis medicine.
10. the arbitrary described treatment gastrointestinal disease Chinese medicine composition of claim 1～3 is at preparation invigorating the spleen to arrest diarrhea, antidiarrheal dysentery relieving, and the application in the blood dysentery relieving medicine.
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Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1368188A (en) * 2001-01-31 2002-09-11 杨孟君 Nano medicine 'Weichangan' and its preparing process
CN1939477A (en) * 2006-09-27 2007-04-04 天津中新药业集团股份有限公司乐仁堂制药厂 Chinese-medicinal composition for treating enterogastric diseases
CN1970010A (en) * 2006-09-27 2007-05-30 天津中新药业集团股份有限公司乐仁堂制药厂 Chinese medicinal formulation for treating gastrointestinal disease

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1368188A (en) * 2001-01-31 2002-09-11 杨孟君 Nano medicine 'Weichangan' and its preparing process
CN1939477A (en) * 2006-09-27 2007-04-04 天津中新药业集团股份有限公司乐仁堂制药厂 Chinese-medicinal composition for treating enterogastric diseases
CN1970010A (en) * 2006-09-27 2007-05-30 天津中新药业集团股份有限公司乐仁堂制药厂 Chinese medicinal formulation for treating gastrointestinal disease

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