CN102416076A - Chinese medicinal composition for treating gastrointestinal disease and preparation method of Chinese medicinal composition - Google Patents

Chinese medicinal composition for treating gastrointestinal disease and preparation method of Chinese medicinal composition Download PDF

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Publication number
CN102416076A
CN102416076A CN2011104033034A CN201110403303A CN102416076A CN 102416076 A CN102416076 A CN 102416076A CN 2011104033034 A CN2011104033034 A CN 2011104033034A CN 201110403303 A CN201110403303 A CN 201110403303A CN 102416076 A CN102416076 A CN 102416076A
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China
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radix
subsequent use
moschus
crude drug
crotonis pulveratum
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陈坚
王磊
袁学海
王伟
杨瑾
王春晨
郝忻
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Lerentang Pharmaceutical Factory of Tianjin Zhongxin Pharmaceutical Group Co Ltd
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Lerentang Pharmaceutical Factory of Tianjin Zhongxin Pharmaceutical Group Co Ltd
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Priority to CN2011104033034A priority Critical patent/CN102416076A/en
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    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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Abstract

The invention relates to a Chinese medicinal composition for treating gastrointestinal diseases and a preparation method of the Chinese medicinal composition. The Chinese medicinal composition for treating gastrointestinal diseases are prepared from costustoot, Chinese eaglewood, bitter orange, sandalwood, rhubarb, officinal magnolia bark, musk and defatted croton seed powder and other medicaments. The Chinese medicinal composition is mainly used for treating diseases such as acute diarrhea, irritable bowel syndrome and the like clinically.

Description

Treatment gastrointestinal disease Chinese medicine composition and preparation method thereof
Technical field
The present invention relates to field of medicaments, particularly relate to treat gastrointestinal disease Chinese medicine composition and preparation method thereof.
Background technology
Diarrhoea can be divided into infectious and non-infectious two types.Infectious diarrhea is divided into bacterial infection and viral infection again; Noninfectious diarrhea then can be caused by the change of improper diet, food anaphylaxis, rule of life, abrupt change of climate even multiple reason such as nervous.Motherland's medical science thinks to have loose bowels and is meant that defecation frequency increases, feces is rare clearly, even like water sample.The major lesions of having loose bowels is taste and intestine and small intestine.Its pathogenesis has being invaded by exogenous pathogen, injury due to diet, seven emotions discord, damp internal resistance and internal organs weakness etc.The clinical findings damp is caused a disease has cold-damp and damp and hot branch.Spleen and stomach function expands, and to hinder be to be caused by multiple factor, has exopathogen influence, taste weakness itself, incoordination between the liver and spleen and kidney intestinal deficiency etc. all can cause spleen and stomach function not normal and have loose bowels.Survey data shows that diarrhoea sickness rate in urban population reaches 0.4 time/people, and the rural population sickness rate reaches 0.5 time/people.Though diarrhoea is minor illness, pathogenic factor also is diversified, and changes with epoch, environment.We can say that the diarrhoea of today and the diarrhoea before 20 years see that from pathogeny the change of essence has been arranged.Along with development of times, people's living standard attains the well-off standard basically, and sanitary condition is improved greatly; Diarrhoea ratio by bacterial infection causes is fewer and feweri, on the contrary, because rhythm of life is accelerated; Struggle for existence is fierce, and the functional diarrhea ratio that pressure causes greatly obviously rises.A research shows that the diarrhoeal diseases people of China about 30% needs antibiosis usually to treat, and 70% does not need should not use antibiotic therapy yet.Consumer also more and more notices the untoward reaction of products such as berberine, norfloxacin, and the harm that abuse of antibiotics brought.Diarrhoea market is except low side antibiotic products such as berberine, norfloxacin; Some non-antibiotic products have also been introduced in recent years; Such as dioctahedral smectite, Birid Triple Viable etc.; But be positioned at high-end consumer groups, for most of consumer groups, its price positioning does not conform to the consumption location of such minor illness of suffering from diarrhoea with consumer.Analysis expert thinks, urban market diarrhoea mainly be with viral be main, be main in the rural area with bacterial infection, if according to the principle of the market segments, at present a lot of products all are difficult to cover the whole market.For alteration of intestinal flora person, available little ecological active bacteria formulation provides probiotics, improves intestinal environment, improves intestinal absorption, kinestate.As: bifidobacteria viable bacteria preparation (the happy capsule of beautiful pearl intestinal), Birid Triple Viable capsule, bacillus cicheniformis (whole intestinal rubber capsule); The intestinal mucosa protective agent: two eight body Montmorillonitums (dioctahedral smectite), the protection intestinal mucosa can suppress fixedly mycin, promotes the intestinal mucosal lesion reparation; Contain the creosote component preparation: the excessive secretion that can suppress intestinal juice.
At present on the market gastrointestinal disease treating pill is mainly used in the diarrhoea that the treatment dyspepsia causes, enteritis, and bacillary dysentery, distension and fullness in the abdomen, stomachache, the food stagnation infantile dyspepsia, its pharmacological action is higher than like product: diarrhea, antibiotic, antiviral, four kinds of functions of adjusting gastrointestinal function are also deposited.But contain Cinnabaris in its prescription; Its effect is a tranquillizing the mind by relieving convulsion; But contain hydrargyrum in the Cinnabaris; Hydrargyrum is very big to the harm of human body, and it is the process of a subtle lasting absorption, and human body contacts hydrargyrum for a long time can cause chronic poisoning: nerve, digestion, hormonal system and kidney to the people produce harm; Neurasthenic crowd may cause symptoms such as headache, dizziness, insomnia, hypomnesis, malaise; And anemia of pregnant woman and the women of age of sucking contact hydrargyrum for a long time, also possibly endanger fetus and baby's health.Mercurous in addition medicine has received certain restriction when exporting other countries, require mercury content to require then strict more for some European countries less than 0.5ppm like Singapore.
Summary of the invention
Problem to be solved by this invention provides treatment gastrointestinal disease Chinese medicine composition.
Another problem to be solved by this invention provides the method for preparing of treatment gastrointestinal disease Chinese medicine composition.
The present invention treats the gastrointestinal disease Chinese medicine composition, is to add other crude drug by basis side to process according to the following weight proportioning:
Said basis side medicine is: the Radix Aucklandiae 150～600g, Lignum Aquilariae Resinatum 150～600g, Fructus Aurantii 150～600g, Lignum Santali Albi 90～360g, Radix Et Rhizoma Rhei 90～360g, Cortex Magnoliae Officinalis 150～600g, Moschus 4.5～18g, Semen Crotonis Pulveratum 60～240g;
Said other crude drug are:
Fructus Jujubae 500～2000g, Rhizoma Chuanxiong 90～360g, Radix Codonopsis 150～600g and Rhizoma Coptidis 100～400g;
Perhaps Fructus Jujubae 500～2000g, Rhizoma Chuanxiong 90～360g, the Rhizoma Atractylodis Macrocephalae 150～600g and Rhizoma Coptidis 100～400g;
Perhaps Fructus Jujubae 500～2000g, Rhizoma Chuanxiong 90～360g, Radix Codonopsis 150～600g, Poria 150～600g, the Rhizoma Atractylodis Macrocephalae 150～600g and Rhizoma Coptidis 100～400g;
Perhaps Rhizoma Chuanxiong 90～360g, Seem Lablab Album 150～600g and Rhizoma Dioscoreae 150～600g;
Perhaps Fructus Jujubae 500～2000g, Rhizoma Chuanxiong 90～360g, Semen Arecae 90～360g and Fructus Crataegi 150～600g;
Perhaps Fructus Jujubae 500～2000g, Rhizoma Chuanxiong 90～360g, Poria 150～600g and JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata) 150～600g;
Perhaps Fructus Jujubae 500～2000g, Rhizoma Chuanxiong 90～360g, Endothelium Corneum Gigeriae Galli 90～360g, JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata) 150～600g and Pericarpium Citri Reticulatae 150～600g;
Perhaps Fructus Jujubae 500～2000g, Rhizoma Chuanxiong 90～360g, Radix Angelicae Sinensis 90～360g;
Perhaps Fructus Jujubae 500～2000g, the Radix Paeoniae Alba 90～360g and Radix Angelicae Sinensis 90～360g;
Perhaps Fructus Jujubae 500～2000g, Rhizoma Chuanxiong 90～360g, Radix Scutellariae 150～600g and Rhizoma Coptidis 150～600g;
In a kind of.
The present invention preferably treats the gastrointestinal disease Chinese medicine composition, is to add other crude drug by basis side to process according to the following weight proportioning:
Said basis side medicine is: the Radix Aucklandiae 250～400g, Lignum Aquilariae Resinatum 250～400g, Fructus Aurantii 250～400g, Lignum Santali Albi 150～250g, Radix Et Rhizoma Rhei 150～250g, Cortex Magnoliae Officinalis 250～400g, Moschus 6～12g, Semen Crotonis Pulveratum 100～150g;
Said other crude drug are:
Fructus Jujubae 800～1200g, Rhizoma Chuanxiong 150～250g, Radix Codonopsis 250～400g and Rhizoma Coptidis 150～300g;
Perhaps Fructus Jujubae 800～1200g, Rhizoma Chuanxiong 150～250g, the Rhizoma Atractylodis Macrocephalae 250～400g and Rhizoma Coptidis 150～300g;
Perhaps Fructus Jujubae 800～1200g, Rhizoma Chuanxiong 150～250g, Radix Codonopsis 250～400g, Poria 250～400g, the Rhizoma Atractylodis Macrocephalae 250～400g and Rhizoma Coptidis 150～300g;
Perhaps Rhizoma Chuanxiong 150～250g, Seem Lablab Album 250～400g and Rhizoma Dioscoreae 250～400g;
Perhaps Fructus Jujubae 800～1200g, Rhizoma Chuanxiong 150～250g, Semen Arecae 120～250g and Fructus Crataegi 250～400g;
Perhaps Fructus Jujubae 800～1200g, Rhizoma Chuanxiong 150～250g, Poria 250～400g and JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata) 250～400g;
Perhaps Fructus Jujubae 800～1200g, Rhizoma Chuanxiong 150～250g, Endothelium Corneum Gigeriae Galli 120～250g, JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata) 250～400g and Pericarpium Citri Reticulatae 150～600g;
Perhaps Fructus Jujubae 800～1200g, Rhizoma Chuanxiong 150～250g, Radix Angelicae Sinensis 120～250g;
Perhaps Fructus Jujubae 800～1200g, the Radix Paeoniae Alba 120～250g and Rhizoma Chuanxiong 150～250g;
Perhaps Fructus Jujubae 800～1200g, Rhizoma Chuanxiong 150～250g, Radix Scutellariae 250～400g and Rhizoma Coptidis 250～400g;
In a kind of.
The further preferred treatment gastrointestinal disease of the present invention Chinese medicine composition is to add other crude drug by basis side to process according to the following weight proportioning:
Said basis side medicine is: Radix Aucklandiae 300g, Lignum Aquilariae Resinatum 300g, Fructus Aurantii 300g, Lignum Santali Albi 180g, Radix Et Rhizoma Rhei 180g, Cortex Magnoliae Officinalis 300g, Moschus 9g, Semen Crotonis Pulveratum 120g;
Said other crude drug are:
Fructus Jujubae 1000g, Rhizoma Chuanxiong 180g, Radix Codonopsis 300g and Rhizoma Coptidis 200g;
Perhaps Fructus Jujubae 1000g, Rhizoma Chuanxiong 180g, Rhizoma Atractylodis Macrocephalae 300g and Rhizoma Coptidis 200g;
Perhaps Fructus Jujubae 1000g, Rhizoma Chuanxiong 180g, Radix Codonopsis 300g, Poria 300g, Rhizoma Atractylodis Macrocephalae 300g and Rhizoma Coptidis 200g;
Perhaps Rhizoma Chuanxiong 180g, Seem Lablab Album 300g and Rhizoma Dioscoreae 300g;
Perhaps Fructus Jujubae 1000g, Rhizoma Chuanxiong 180g, Semen Arecae 180g and Fructus Crataegi 300g;
Perhaps Fructus Jujubae 1000g, Rhizoma Chuanxiong 180g, Poria 300g and JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata) 300g;
Perhaps Fructus Jujubae 1000g, Rhizoma Chuanxiong 180g, Endothelium Corneum Gigeriae Galli 180g, JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata) 300g and Pericarpium Citri Reticulatae 300g;
Perhaps Fructus Jujubae 1000g, Rhizoma Chuanxiong 180g, Radix Angelicae Sinensis 180g;
Perhaps Fructus Jujubae 1000g, Radix Paeoniae Alba 180g and Rhizoma Chuanxiong 180g;
Perhaps Fructus Jujubae 1000g, Rhizoma Chuanxiong 180g, Radix Scutellariae 300g and Rhizoma Coptidis 300g;
In a kind of.
The present invention treats the gastrointestinal disease Chinese medicine composition, can adopt following method to prepare active component for crude drug: like one or several Combined application preparations in water extraction, decoction and alcohol sedimentation technique, extraction, infusion process, percolation, reflux extraction, continuous backflow extraction method, the macroreticular resin absorbing method.But in order to make each crude drug of this medicine bring into play drug effect better, the present invention preferably adopts following technology to extract active component to raw material, and processes the present invention and treat the gastrointestinal disease Chinese medicine composition, but this can not limit protection scope of the present invention.
The present invention treats the gastrointestinal disease Chinese medicine composition, and employing is prepared as follows method and processes:
A. getting the weight proportion crude drug, to prepare active component according to present conventional method for preparing subsequent use;
B. the active component that obtains is processed preparation.
The preparation that the present invention treats among the gastrointestinal disease Chinese medicine composition method for preparing step b is tablet, granule, honey pill agent, watered pill, drop pill, hard capsule, soft capsule, patch, cataplasma, ointment, gel.
The Fructus Aurantii that the present invention treats in the gastrointestinal disease Chinese medicine composition is a stir-baked Fructus Aurantii in bran; Cortex Magnoliae Officinalis is a Cortex Magnoliae Officinalis (processed with ginger); Fructus Jujubae is the Fructus Jujubae of enucleation.
The present invention treats the application of gastrointestinal disease Chinese medicine composition in preparation treatment irritable bowel syndrome medicine.
The present invention treats the application of gastrointestinal disease Chinese medicine composition in preparation treatment acute diarrhea, bacillary dysentery, enteritis, lienteric diarrhea medicine.
The present invention treats the gastrointestinal disease Chinese medicine composition in preparation treatment eliminating turbid pathogen with aromatics, regulating QI to relieve pain, the application in the consumer product dredge stasis medicine.
The present invention treats the gastrointestinal disease Chinese medicine composition in preparation treatment invigorating the spleen to arrest diarrhea, the application in antidiarrheal dysentery relieving and the blood dysentery relieving medicine.
More than form when producing and to increase or to reduce according to corresponding ratio; Like large-scale production can be unit with kilogram or with the ton; Small-scale production can be unit with the gram also, and weight can increase or reduce, but the crude drug material weight proportion constant rate between each composition.
In order to understand the present invention better, further set forth the beneficial effect of medicine of the present invention below through Drug therapy chronic gastrointestinal disease 100 routine clinical verification case summaries of the present invention.Below used medicine of the present invention prepares according to embodiment 6 methods in the test.
One, observational technique
(1) object of observation: this group case is the out-patient, and untreated or treatment be person more, comprises functional diarrhea, functional dyspepsia, and irritable bowel syndrome, chronic and infective diarrhea is the object of observation.
(2) diagnostic criteria
Adopt " Rome II standard in 1999 ", selected case meets the diagnostic criteria of functional diarrhea, functional dyspepsia, irritable bowel syndrome, chronic and infective diarrhea.All cases are got rid of stomach, duodenum, colon organic disease all through stomach, colon scope or X line barium examination.
(3) rejecting standard
1, organic digestive system disease person is arranged, like polyp, tumor etc.
2, Liver and kidney is arranged, endocrine, the serious protopathy person of immune system and blood system: diabetes, uremia, hepatopathy etc.
3, anemia of pregnant woman and women breast-feeding their children.
4, do not meet diagnostic criteria.
(4) symptom degree evaluation standard
With reference to " new Chinese medicine clinical guidance principle ": according to symptom light, in, severe remembers 1,2,3 fen respectively.
1, symptom scoring method:
(1) asymptomatic (-): remember 0 fen;
(2) slight (+): occur note 1 minute once in a while;
(3) moderate (++): note 2 minutes often occur;
(4) severe (+++): continue to exist note 3 minutes.
2, have loose bowels:
(1) the asymptomatic and soft change (-) that is shaped: every day, 1-2 note was 0 minute;
(2) slight (+): symptom is slight, does not influence live and work, can stand, and stool every day 2-3 time, mushy stool or Mucous Stool are remembered 1 fen;
(3) moderate (++): symptom is heavier, has influenced work, life, still can stand, and stool is the egg style, every day 4-5 time, or the Mucous Stool moderate is remembered 2 fens;
(4) severe (+++): serious symptom, hinder one's work and live, be difficult to stand, rare watery stool, every day is more than 6 times, or a large amount of notes of Mucous Stool 3 minutes.
3, the deciding degree standard of disease
(1) severe: the cardinal symptom integration=＞total mark 70%;
(2) moderate: 70% of 30%＜=cardinal symptom integration＜total mark;
(3) slight: 30% of cardinal symptom integration＜=total mark;
(5) curative effect determinate standard and statistical method
Reference " new Chinese medicine clinical guidance principle " is as standard.
1, curative effect determinate standard:
(1) cure: cardinal symptom disappears, and stool is shaped, and every day 1-2 time, therapeutic index is 100%;
(2) produce effects: main clinic symptoms disappears basically, times of defecation every day 2-3 time, 75%＜=therapeutic index＜100%;
(3) effective: main clinic symptoms takes a turn for the better, and stool shape and time number average take a favorable turn 30%＜=therapeutic index＜75%;
(4) invalid: main clinic symptoms does not have change, therapeutic index＜30%;
The total score value of cardinal symptom * 100% before curative effect of disease index=(the total score value of cardinal symptom before the treatment-total score value of treatment back cardinal symptom)/treatment.
2, individual event symptom therapeutic evaluation standard:
(1) cure: after finishing the course of treatment, transference cure;
(2) produce effects: after curative effect finished, the symptom classification reduced 2 grades;
(3) effective: after curative effect finished, the symptom classification reduced 1 grade;
(4) invalid: as not reach above-mentioned standard.
(6) observation index
1, health giving quality is observed:
(1) before the treatment, the variation of sings and symptoms in the course of treatment.
(2) every day times of defecation, amount.
(3) stool shape is just wait like bloody purulent stool, Mucous Stool and rare water.
(4) stool routine examination inspection: erythrocyte, leukocyte and pus cell quantity in the stool have or not indigestion dietary fiber, fat drop etc.
(5) the part patient does just and cultivates.
(6) the part patient does colonoscope, intestinal radiography, gastroscope.
3, safety is observed:
(1) blood, routine urianlysis.
(2) just routine test.
4, main clinic symptoms is observed:
(1) functional diarrhea: diarrhoea, with tenesmus, watery stool, Mucous Stool.
(2) functional dyspepsia: upper abdomen is glutted, morning is full, belch, Upper abdominal pain, nausea and vomiting, acid regurgitation.
(3) irritable bowel syndrome: stomachache, abdominal distention, diarrhoea, just not to the utmost, times of defecation, shape.
(4) chronic and infective diarrhea: diarrhoea, stomachache, tenesmus, the dense hemafecia of mucus.
Two, clinical data
Therapeutic Method
All the cases other treatment medicine of during medication, stopping using uses medicine of the present invention merely, and usage and dosage is 10 balls/inferior, and 3 times/day, be 4 weeks the course of treatment.
Statistical method
Enumeration data is used X 2Check, measurement data are used the t check.
Observed result
1, each sick clinical treatment front and back total effects of planting is observed, and is as shown in table 1
Each sick clinical treatment front and back total effects table of planting of table 1
Figure BSA00000630647400071
2, each sick clinical treatment front and back obvious effective rate comparable situation of planting is as shown in table 2
Each sick clinical treatment front and back obvious effective rate comparison sheet of planting of table 2
Figure BSA00000630647400072
Four kinds of sick X 2Relatively, P＞0.05 not statistically significant explains that this medicine all has significant therapeutic effect to above-mentioned 4 kinds of diseases.
Three, the result shows
1, various chronic gastrointestinal disease had the good curing effect
Clinical effectiveness shows that the sick statistical effect of planting of each of Drug therapy chronic gastrointestinal disease of the present invention is learned there was no significant difference, and explaining all has good therapeutical effect to various chronic gastrointestinal disease.
2, has the obvious effect that improves chronic gastrointestinal disease patient clinical symptoms
Clinical effectiveness shows that medicine of the present invention is relieve clinical symptoms obviously.To single sick plant primary symptom to improve effect obvious, total effective rate is all more than 85%.
3, do not find apparent side effect during the medication.
The specific embodiment
Below further set forth the method for preparing of medicine of the present invention through embodiment.
Embodiment 1
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 150g, Lignum Aquilariae Resinatum 150g, Fructus Aurantii 150g, Lignum Santali Albi 90g, Radix Et Rhizoma Rhei 90g, Cortex Magnoliae Officinalis 150g, Moschus 4.5g, Semen Crotonis Pulveratum 60g, Fructus Jujubae 500g, Rhizoma Chuanxiong 90g, Radix Codonopsis 150g and Rhizoma Coptidis 100g are subsequent use;
B. above crude drug, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is subsequent use; Pulverizing such as the Radix Aucklandiae, Lignum Aquilariae Resinatum, Fructus Aurantii, Lignum Santali Albi, Radix Et Rhizoma Rhei, Cortex Magnoliae Officinalis, CO 2Supercritical extraction; Get extract, add an amount of anhydrous alcohol solution, carry out enclose with an amount of β-CD, drying promptly gets clathrate, and is subsequent use; With the medicinal residues ethanol extraction secondary behind the above-mentioned supercritical extraction, merge secondary filtrating, reclaim ethanol and concentrate subsequent use; Get Fructus Jujubae decocte with water secondary, filter; Merging filtrate concentrates, and with above-mentioned alcohol extract condensed cream mixing, drying is ground into fine powder, with clathrate, Semen Crotonis Pulveratum, the Moschus mixing that sieves, sieves again, and is subsequent use; Process tablet according to method for preparing tablet thereof.
Embodiment 2
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 600g, Lignum Aquilariae Resinatum 600g, Fructus Aurantii 600g, Lignum Santali Albi 360g, Radix Et Rhizoma Rhei 360g, Cortex Magnoliae Officinalis 600g, Moschus 18g, Semen Crotonis Pulveratum 240g, Fructus Jujubae 2000g, Rhizoma Chuanxiong 360g, Radix Codonopsis 600g and Rhizoma Coptidis 400g are subsequent use;
B. above crude drug, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is subsequent use; The Radix Aucklandiae, Lignum Aquilariae Resinatum, Fructus Aurantii, Lignum Santali Albi, Radix Et Rhizoma Rhei, Cortex Magnoliae Officinalis etc. are broken into coarse powder, add water, soak, and decocting boils distillation, collect volatile oil, and be after β-CD inclusion, subsequent use; Decocting liquid filters, and filtrating concentrates subsequent use, and medicinal residues and Lignum Santali Albi coarse powder add alcohol reflux 2 times, filters; Merge secondary filtrating, concentrate, drying, subsequent use; Get Fructus Jujubae, add decocting and boil secondary, filter; Merge secondary filtrating, concentrate, drying, the above-mentioned fine powder that is dried and crushed into, with Semen Crotonis Pulveratum, Moschus mixing, subsequent use; Process granule according to process for producing granula, promptly get.
Embodiment 3
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 150g, Lignum Aquilariae Resinatum 150g, Fructus Aurantii 150g, Lignum Santali Albi 90g, Radix Et Rhizoma Rhei 90g, Cortex Magnoliae Officinalis 150g, Moschus 4.5g, Semen Crotonis Pulveratum 60g, Fructus Jujubae 500g, Rhizoma Chuanxiong 90g, Rhizoma Atractylodis Macrocephalae 150g and Rhizoma Coptidis 100g are subsequent use;
B. above crude drug, Semen Crotonis Pulveratum, Moschus pulverize separately become fine powder; Decocte with water such as all the other Radix Aucklandiae, Lignum Aquilariae Resinatum, Fructus Aurantii, Lignum Santali Albi, Radix Et Rhizoma Rhei, Cortex Magnoliae Officinalis 2 times, each 2 hours, collecting decoction filtered, and is condensed into thick paste, in above-mentioned thick paste, adds Semen Crotonis Pulveratum, Moschus powder, and mixing is subsequent use; Get an amount of polyethylene glycol 6000, heating makes fusion, adds above-mentioned thick paste and Semen Crotonis Pulveratum, Moschus mixture of powders, mixing, and adopting a speed is 85～90/min, splashes in the refrigerative liquid paraffin, processes drop pill, promptly gets.
Embodiment 4
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 600g, Lignum Aquilariae Resinatum 600g, Fructus Aurantii 600g, Lignum Santali Albi 360g, Radix Et Rhizoma Rhei 360g, Cortex Magnoliae Officinalis 600g, Moschus 18g, Semen Crotonis Pulveratum 240g, Fructus Jujubae 2000g, Rhizoma Chuanxiong 360g, Rhizoma Atractylodis Macrocephalae 600g and Rhizoma Coptidis 400g are subsequent use;
B. above crude drug, Semen Crotonis Pulveratum, Moschus pulverize separately become fine powder; All the other crude drug decocte with water 2 times, each 3 hours, collecting decoction filtered, and is condensed into thick paste, adds above-mentioned thick paste and Semen Crotonis Pulveratum, Moschus powder, and mixing is subsequent use; Get an amount of Macrogol 4000, heating makes fusion, adds said mixture, mixing, and adopting a speed is 60～80/min, splashes in the refrigerative methyl-silicone oil, processes drop pill, promptly gets.
Embodiment 5
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 150g, Lignum Aquilariae Resinatum 150g, Fructus Aurantii 150g, Lignum Santali Albi 90g, Radix Et Rhizoma Rhei 90g, Cortex Magnoliae Officinalis 150g, Moschus 4.5g, Semen Crotonis Pulveratum 60g, Fructus Jujubae 500g, Rhizoma Chuanxiong 90g, Radix Codonopsis 150g, Poria 150g, Rhizoma Atractylodis Macrocephalae 150g and Rhizoma Coptidis 100g are subsequent use;
B. above crude drug, Semen Crotonis Pulveratum, Moschus pulverize separately become fine powder; All the other crude drug decocte with water 3 times, each 2 hours, collecting decoction filtered, and is condensed into thick paste, adds above-mentioned thick paste and Semen Crotonis Pulveratum, Moschus powder, and mixing is subsequent use; Get an amount of polyethylene glycol 6000: polyethylene glycol 1500 is 3: 1 a mixture, and heating dissolves, and adds above-mentioned thick paste and Semen Crotonis Pulveratum, Moschus powder, mixing, and adopting a speed is 20～80/min, splashes in the refrigerative liquid paraffin, processes drop pill, promptly gets.
Embodiment 6
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 600g, Lignum Aquilariae Resinatum 600g, Fructus Aurantii 600g, Lignum Santali Albi 360g, Radix Et Rhizoma Rhei 360g, Cortex Magnoliae Officinalis 600g, Moschus 18g, Semen Crotonis Pulveratum 240g, Fructus Jujubae 2000g, Rhizoma Chuanxiong 360g, Radix Codonopsis 600g, Poria 600g, Rhizoma Atractylodis Macrocephalae 600g and Rhizoma Coptidis 400g are subsequent use;
B. above crude drug, Semen Crotonis Pulveratum, Moschus pulverize separately become fine powder; All the other crude drug decocte with water 2 times, each 2 hours, collecting decoction filters, and is condensed into thick paste, and was subsequent use; Taking polyethylene glycol 6000: the mixture Polyethylene Glycol of Macrogol 4000=4: 3 is an amount of, and heating makes fusion, adds above-mentioned thick paste and Semen Crotonis Pulveratum, Moschus powder; Mixing, adopting a speed is 40～60/min, splashes in the refrigerative liquid paraffin; Process drop pill, promptly get.
Embodiment 7
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 150g, Lignum Aquilariae Resinatum 150g, Fructus Aurantii 150g, Lignum Santali Albi 90g, Radix Et Rhizoma Rhei 90g, Cortex Magnoliae Officinalis 150g, Moschus 4.5g, Semen Crotonis Pulveratum 60g, Rhizoma Chuanxiong 90g, Seem Lablab Album 150g and Rhizoma Dioscoreae 150g are subsequent use;
B. above crude drug, Semen Crotonis Pulveratum, Moschus pulverize separately become fine powder; All the other crude drug decocte with water 2 times, each 2 hours, collecting decoction filters, and is condensed into thick paste, and was subsequent use; Get an amount of polyethylene glycol 6000: the polyethylene glycol 6000 and the Macrogol 4000 mixture of Macrogol 4000=5: 1 add above-mentioned thick paste and Semen Crotonis Pulveratum, Moschus powder, mixing; Heating dissolves, and adopting a speed is 65～75/min, splashes in the refrigerative liquid paraffin; Process drop pill, promptly get.
Embodiment 8
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 600g, Lignum Aquilariae Resinatum 600g, Fructus Aurantii 600g, Lignum Santali Albi 360g, Radix Et Rhizoma Rhei 360g, Cortex Magnoliae Officinalis 600g, Moschus 18g, Semen Crotonis Pulveratum 240g, Rhizoma Chuanxiong 360g, Seem Lablab Album 600g and Rhizoma Dioscoreae 600g are subsequent use;
B. above crude drug, Semen Crotonis Pulveratum, Moschus pulverize separately become fine powder; All the other crude drug decocte with water 2 times, each 2 hours, collecting decoction filters, and is condensed into thick paste, and was subsequent use; Taking polyethylene glycol 6000: the mixture Polyethylene Glycol of Macrogol 4000=3: 2 is an amount of, and heating makes fusion, adds above-mentioned thick paste and Semen Crotonis Pulveratum, Moschus powder; Mixing, adopt dripping speed is 50～60/min, splashes into methyl-silicone oil: in the condensed fluid of liquid Paraffin=4: 1; Promptly get drop pill, promptly get.
Embodiment 9
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 150g, Lignum Aquilariae Resinatum 150g, Fructus Aurantii 150g, Lignum Santali Albi 90g, Radix Et Rhizoma Rhei 90g, Cortex Magnoliae Officinalis 150g, Moschus 4.5g, Semen Crotonis Pulveratum 60g, Fructus Jujubae 500g, Rhizoma Chuanxiong 90g, Semen Arecae 90g and Fructus Crataegi 150g are subsequent use;
B. above crude drug, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is subsequent use; Crude drug such as the Radix Aucklandiae, Lignum Aquilariae Resinatum, Rhizoma Coptidis, Fructus Aurantii Immaturus, Rhizoma Atractylodis, Rhizoma Chuanxiong are ground into coarse powder, add 16 times of water gagings, soak 4 hours, and decocting boils distillation 8h altogether, collects volatile oil, and is after β-CD inclusion, subsequent use; Decocting liquid filters, relative density 1.25-1.30 when filtrating is concentrated into 60 ℃, and subsequent use, medicinal residues and Lignum Santali Albi coarse powder add 70% alcohol reflux 2 times, for the first time 2h; 1h filters for the second time; Merge secondary filtrating, relative density 1.20-1.25 when being concentrated into 60 ℃, drying, subsequent use; Get Fructus Jujubae, add decocting and boil secondary, each 2h filters; Merge secondary filtrating, and relative density 1.28-1.32 when being concentrated into 60 ℃ (60 ℃, drying, subsequent use with the above-mentioned fine powder that is dried and crushed into Semen Crotonis Pulveratum, Moschus mixing, process granule.
Embodiment 10
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 600g, Lignum Aquilariae Resinatum 600g, Fructus Aurantii 600g, Lignum Santali Albi 360g, Radix Et Rhizoma Rhei 360g, Cortex Magnoliae Officinalis 600g, Moschus 18g, Semen Crotonis Pulveratum 240g, Fructus Jujubae 2000g, Rhizoma Chuanxiong 360g, Semen Arecae 360g and Fructus Crataegi 600g are subsequent use;
B. above crude drug, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is subsequent use; Crude drug such as all the other Radix Aucklandiae, Lignum Aquilariae Resinatum, Rhizoma Coptidis, Fructus Aurantii Immaturus, Rhizoma Atractylodis, Rhizoma Chuanxiong, Lignum Santali Albi are ground into 40 purpose powder, CO 2Supercritical extraction, extracting pressure 5MPa, 35 ℃ of temperature, CO 2Flow velocity 20L/h, extraction 2h; Get extract, add an amount of anhydrous alcohol solution,, adopt polishing to carry out enclose,, promptly get clathrate in 40 ℃ of vacuum dryings with an amount of β-CD, subsequent use; Medicinal residues behind the above-mentioned supercritical extraction are added 60% ethanol extraction secondary, merge secondary filtrating, reclaiming ethanol to relative density is that 1.25-1.30 (60 ℃) is subsequent use; Get Fructus Jujubae decocte with water secondary, each 2h filters; Merging filtrate is concentrated into relative density 1.25-1.30 (60 ℃), and with above-mentioned alcohol extract condensed cream mixing, drying is ground into fine powder, with clathrate, Semen Crotonis Pulveratum, the Moschus mixing that sieves, crosses 80 mesh sieves again, and is subsequent use, processes tablet according to method for preparing tablet thereof.
Embodiment 11
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 150g, Lignum Aquilariae Resinatum 150g, Fructus Aurantii 150g, Lignum Santali Albi 90g, Radix Et Rhizoma Rhei 90g, Cortex Magnoliae Officinalis 150g, Moschus 4.5g, Semen Crotonis Pulveratum 60g, Fructus Jujubae 500g, Rhizoma Chuanxiong 90g, Poria 150g and JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata) 150g are subsequent use;
B. above crude drug, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is subsequent use; Pulverizing such as all the other Radix Aucklandiae, Lignum Aquilariae Resinatum, Fructus Aurantii, Lignum Santali Albi, Radix Et Rhizoma Rhei, Cortex Magnoliae Officinalis, CO 2Supercritical extraction; Get extract, add an amount of anhydrous alcohol solution, carry out enclose with an amount of β-CD, drying promptly gets clathrate, and is subsequent use; With the medicinal residues ethanol extraction secondary behind the above-mentioned supercritical extraction, merge secondary filtrating, reclaim ethanol and concentrate subsequent use; Get Fructus Jujubae decocte with water secondary, filter; Merging filtrate concentrates, and with above-mentioned alcohol extract condensed cream mixing, drying is ground into fine powder, with clathrate, Semen Crotonis Pulveratum, the Moschus mixing that sieves, sieves again, and is subsequent use, encapsulated, promptly gets.
Embodiment 12
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 600g, Lignum Aquilariae Resinatum 600g, Fructus Aurantii 600g, Lignum Santali Albi 360g, Radix Et Rhizoma Rhei 360g, Cortex Magnoliae Officinalis 600g, Moschus 18g, Semen Crotonis Pulveratum 240g, Fructus Jujubae 2000g, Rhizoma Chuanxiong 360g, Poria 600g and JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata) 600g are subsequent use;
B. above crude drug, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is subsequent use; All the other Radix Aucklandiae, Lignum Aquilariae Resinatum, Fructus Aurantii, Lignum Santali Albi, Radix Et Rhizoma Rhei, Cortex Magnoliae Officinalis etc. are ground into coarse powder, add water, soak, and decocting boils distillation, collect volatile oil, and be after β-CD inclusion, subsequent use; Decocting liquid filters, and filtrating concentrates subsequent use, and medicinal residues and Lignum Santali Albi coarse powder add alcohol reflux 2 times, filters; Merge secondary filtrating, concentrate, drying, subsequent use; Get Fructus Jujubae, add decocting and boil secondary, filter; Merge secondary filtrating, concentrate, drying, the above-mentioned fine powder that is dried and crushed into, subsequent use, encapsulated with Semen Crotonis Pulveratum, Moschus mixing, promptly get.
Embodiment 13
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 150g, Lignum Aquilariae Resinatum 150g, Fructus Aurantii 150g, Lignum Santali Albi 90g, Radix Et Rhizoma Rhei 90g, Cortex Magnoliae Officinalis 150g, Moschus 4.5g, Semen Crotonis Pulveratum 60g, Fructus Jujubae 500g, Rhizoma Chuanxiong 90g, Endothelium Corneum Gigeriae Galli 90g, JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata) 150g and Pericarpium Citri Reticulatae 150g are subsequent use;
B. above crude drug, Semen Crotonis Pulveratum, Moschus pulverize separately become fine powder; All the other crude drug decocte with water 3 times, each 1 hour, collecting decoction filtered, and is condensed into thick paste; In above-mentioned thick paste, add Semen Crotonis Pulveratum, Moschus powder, mixing, subsequent use, encapsulated, promptly get.
Embodiment 14
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 600g, Lignum Aquilariae Resinatum 600g, Fructus Aurantii 600g, Lignum Santali Albi 360g, Radix Et Rhizoma Rhei 360g, Cortex Magnoliae Officinalis 600g, Moschus 18g, Semen Crotonis Pulveratum 240g, Fructus Jujubae 2000g, Rhizoma Chuanxiong 360g, Endothelium Corneum Gigeriae Galli 360g, JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata) 600g and Pericarpium Citri Reticulatae 600g are subsequent use;
B. go up ten flavors, Semen Crotonis Pulveratum, Moschus pulverize separately become fine powder; All the other crude drug decocte with water 2 times, each 3 hours, collecting decoction filtered, and is condensed into thick paste; In above-mentioned thick paste, add Semen Crotonis Pulveratum, Moschus powder, mixing, subsequent use; Encapsulated, promptly get.
Embodiment 15
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 150g, Lignum Aquilariae Resinatum 150g, Fructus Aurantii 150g, Lignum Santali Albi 90g, Radix Et Rhizoma Rhei 90g, Cortex Magnoliae Officinalis 150g, Moschus 4.5g, Semen Crotonis Pulveratum 60g, Fructus Jujubae 500g, Rhizoma Chuanxiong 90g, Radix Angelicae Sinensis 90g is subsequent use;
B. above crude drug, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is subsequent use; All the other Radix Aucklandiae, Lignum Aquilariae Resinatum, Fructus Aurantii, Lignum Santali Albi, Radix Et Rhizoma Rhei, Cortex Magnoliae Officinalis etc. are ground into 80 purpose powder, CO 2Supercritical extraction, extracting pressure 40MPa, 60 ℃ of temperature, CO 2Flow velocity 35L/h, extraction 5h; Get extract, add an amount of anhydrous alcohol solution,, adopt polishing to carry out enclose,, promptly get clathrate in 40 ℃ of vacuum dryings with an amount of β-CD, subsequent use; Medicinal residues behind the above-mentioned supercritical extraction are added 60% ethanol extraction secondary, merge secondary filtrating, relative density is that 1.25-1.30 is subsequent use when reclaiming ethanol to 60 ℃; Get Fructus Jujubae decocte with water secondary, each 2h filters; Merging filtrate, relative density 1.25-1.30 when being concentrated into 60 ℃, with above-mentioned alcohol extract condensed cream mixing, drying is ground into fine powder, with clathrate, Semen Crotonis Pulveratum, the Moschus mixing that sieves, crosses 80 mesh sieves again, and is subsequent use; Encapsulated, promptly get.
Embodiment 16
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 600g, Lignum Aquilariae Resinatum 600g, Fructus Aurantii 600g, Lignum Santali Albi 360g, Radix Et Rhizoma Rhei 360g, Cortex Magnoliae Officinalis 600g, Moschus 18g, Semen Crotonis Pulveratum 240g, Fructus Jujubae 2000g, Rhizoma Chuanxiong 360g, Radix Angelicae Sinensis 360g is subsequent use;
B. above crude drug, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is subsequent use; All the other Radix Aucklandiae of wood, Lignum Aquilariae Resinatum, Fructus Aurantii, Lignum Santali Albi, Radix Et Rhizoma Rhei, Cortex Magnoliae Officinalis medicated powder are broken into coarse powder, add 16 times of water gagings, soak 4 hours, and decocting boils distillation 8h altogether, collects volatile oil, and is after β-CD inclusion, subsequent use; Decocting liquid filters, and relative density 1.25-1.30 was subsequent use when filtrating was concentrated into 60 ℃, and medicinal residues and Lignum Santali Albi coarse powder add 70% alcohol reflux 2 times, for the first time 2h; 1h filters for the second time; Merge secondary filtrating, relative density 1.20-1.25 when being concentrated into 60 ℃, drying, subsequent use; Get Fructus Jujubae, add decocting and boil secondary, each 2h filters; Merge secondary filtrating, relative density 1.28-1.32 when being concentrated into 60 ℃, drying, subsequent use with the above-mentioned fine powder that is dried and crushed into Semen Crotonis Pulveratum, Moschus mixing, add appropriate amount of auxiliary materials, process 36000 capsules, promptly get.
Embodiment 17
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 150g, Lignum Aquilariae Resinatum 150g, Fructus Aurantii 150g, Lignum Santali Albi 90g, Radix Et Rhizoma Rhei 90g, Cortex Magnoliae Officinalis 150g, Moschus 4.5g, Semen Crotonis Pulveratum 60g, Fructus Jujubae 500g, Radix Paeoniae Alba 90g and Radix Angelicae Sinensis 90g are subsequent use;
B. above crude drug, Semen Crotonis Pulveratum, Moschus pulverize separately become fine powder; All the other crude drug decocte with water 2 times, each 2 hours, collecting decoction filtered, and is condensed into thick paste; In above-mentioned thick paste, add Semen Crotonis Pulveratum, Moschus powder, mixing, subsequent use; Add sodium carboxymethyl cellulose, Icing Sugar, mixing, the system granule sieves, and drying promptly gets.
Embodiment 18
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 150g, Lignum Aquilariae Resinatum 150g, Fructus Aurantii 150g, Lignum Santali Albi 90g, Radix Et Rhizoma Rhei 90g, Cortex Magnoliae Officinalis 150g, Moschus 4.5g, Semen Crotonis Pulveratum 60g, Fructus Jujubae 500g, Radix Paeoniae Alba 90g and Radix Angelicae Sinensis 90g are subsequent use;
B. above crude drug, Semen Crotonis Pulveratum, Moschus pulverize separately become fine powder; All the other crude drug decocte with water 2 times, each 2 hours, collecting decoction filtered, and is condensed into thick paste; In above-mentioned thick paste, add Semen Crotonis Pulveratum, Moschus powder, mixing, subsequent use; Add sodium carboxymethyl cellulose, Icing Sugar, mixing, the system granule sieves, and drying promptly gets.
Embodiment 19
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 150g, Lignum Aquilariae Resinatum 150g, Fructus Aurantii 150g, Lignum Santali Albi 90g, Radix Et Rhizoma Rhei 90g, Cortex Magnoliae Officinalis 150g, Moschus 4.5g, Semen Crotonis Pulveratum 60g, Fructus Jujubae 500g, Rhizoma Chuanxiong 90g, Radix Scutellariae 150g and Rhizoma Coptidis 150g are subsequent use;
B. above crude drug, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is subsequent use; Pulverizing such as all the other Radix Aucklandiae, Lignum Aquilariae Resinatum, Fructus Aurantii, Lignum Santali Albi, Radix Et Rhizoma Rhei, Cortex Magnoliae Officinalis, CO 2Supercritical extraction; Get extract, add an amount of anhydrous alcohol solution, carry out enclose with an amount of β-CD, drying promptly gets clathrate, and is subsequent use; With the medicinal residues ethanol extraction secondary behind the above-mentioned supercritical extraction, merge secondary filtrating, reclaim ethanol and concentrate subsequent use; Get Fructus Jujubae decocte with water secondary, filter; Merging filtrate concentrates, and with above-mentioned alcohol extract condensed cream mixing, drying is ground into fine powder, with clathrate, Semen Crotonis Pulveratum, the Moschus mixing that sieves, sieves again, and is subsequent use; Add an amount of magnesium stearate, mixing, compacting promptly gets.
Embodiment 20
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 600g, Lignum Aquilariae Resinatum 600g, Fructus Aurantii 600g, Lignum Santali Albi 360g, Radix Et Rhizoma Rhei 360g, Cortex Magnoliae Officinalis 600g, Moschus 18g, Semen Crotonis Pulveratum 240g, Fructus Jujubae 2000g, Rhizoma Chuanxiong 360g, Radix Scutellariae 600g and Rhizoma Coptidis 600g are subsequent use;
B. above crude drug, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is subsequent use; All the other Radix Aucklandiae, Lignum Aquilariae Resinatum, Fructus Aurantii, Lignum Santali Albi, Radix Et Rhizoma Rhei, Cortex Magnoliae Officinalis etc. are ground into coarse powder, add water, soak, and decocting boils distillation, collect volatile oil, and be after β-CD inclusion, subsequent use; Decocting liquid filters, and filtrating concentrates subsequent use, and medicinal residues and Lignum Santali Albi coarse powder add alcohol reflux 2 times, filters; Merge secondary filtrating, concentrate, drying, subsequent use; Get Fructus Jujubae, add decocting and boil secondary, filter; Merge secondary filtrating, concentrate, drying, the above-mentioned fine powder that is dried and crushed into, with Semen Crotonis Pulveratum, Moschus mixing, subsequent use; Add an amount of magnesium stearate, mixing, compacting promptly gets.
Embodiment 21
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 250g, Lignum Aquilariae Resinatum 250g, Fructus Aurantii 250g, Lignum Santali Albi 150g, Radix Et Rhizoma Rhei 150g, Cortex Magnoliae Officinalis 250g, Moschus 6g, Semen Crotonis Pulveratum 100g, Fructus Jujubae 800g, Rhizoma Chuanxiong 150g, Radix Codonopsis 250g and Rhizoma Coptidis 150g are subsequent use;
B. above crude drug, Semen Crotonis Pulveratum, Moschus pulverize separately become fine powder; All the other crude drug decocte with water 3 times, each 3 hours, collecting decoction filtered, and is condensed into thick paste; In above-mentioned thick paste, add Semen Crotonis Pulveratum, Moschus powder, mixing, subsequent use; Add mixings such as starch, microcrystalline Cellulose, sieve, process granule, add volatile oil such as the Radix Aucklandiae again, mixing, drying adds an amount of magnesium stearate, mixing, compacting promptly gets.
Embodiment 22
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 400g, Lignum Aquilariae Resinatum 400g, Fructus Aurantii 400g, Lignum Santali Albi 250g, Radix Et Rhizoma Rhei 250g, Cortex Magnoliae Officinalis 400g, Moschus 12g, Semen Crotonis Pulveratum 150g, Fructus Jujubae 1200g, Rhizoma Chuanxiong 250g, Radix Codonopsis 400g and Rhizoma Coptidis 300g are subsequent use;
B. above crude drug, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is subsequent use; All the other Radix Aucklandiae, Lignum Aquilariae Resinatum, Fructus Aurantii, Lignum Santali Albi, Radix Et Rhizoma Rhei, Cortex Magnoliae Officinalis etc. are ground into 60 purpose powder, CO 2Supercritical extraction, extracting pressure 10MPa, 50 ℃ of temperature, CO 2Flow velocity 25L/h, extraction 3h; Get extract, add an amount of anhydrous alcohol solution,, adopt polishing to carry out enclose,, promptly get clathrate in 40 ℃ of vacuum dryings with an amount of β-CD, subsequent use; Medicinal residues behind the above-mentioned supercritical extraction are added 60% ethanol extraction secondary, merge secondary filtrating, relative density is that 1.25-1.30 is subsequent use when reclaiming ethanol to 60 ℃; Get Fructus Jujubae decocte with water secondary, each 2h filters; Merging filtrate, relative density 1.25-1.30 when being concentrated into 60 ℃, with above-mentioned alcohol extract condensed cream mixing, drying is ground into fine powder, with clathrate, Semen Crotonis Pulveratum, the Moschus mixing that sieves, crosses 80 mesh sieves again, and is subsequent use; Add 2 ‰ magnesium stearate, mixing, compacting promptly gets in flakes.
Embodiment 23
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 250g, Lignum Aquilariae Resinatum 250g, Fructus Aurantii 250g, Lignum Santali Albi 150g, Radix Et Rhizoma Rhei 150g, Cortex Magnoliae Officinalis 250g, Moschus 6g, Semen Crotonis Pulveratum 100g, Fructus Jujubae 800g, Rhizoma Chuanxiong 150g, Rhizoma Atractylodis Macrocephalae 250g and Rhizoma Coptidis 150g are subsequent use;
B. above crude drug, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is subsequent use; All the other Radix Aucklandiae, Lignum Aquilariae Resinatum, Fructus Aurantii, Lignum Santali Albi, Radix Et Rhizoma Rhei, Cortex Magnoliae Officinalis etc. are ground into coarse powder, add 10 times of water gagings, soak 4 hours, and decocting boils distillation 8h altogether, collects volatile oil, and is after β-CD inclusion, subsequent use; Decocting liquid filters, and relative density 1.25-1.30 was subsequent use when filtrating was concentrated into 60 ℃, and medicinal residues and Lignum Santali Albi coarse powder add 70% alcohol reflux 2 times, for the first time 2h; 1h filters for the second time; Merge secondary filtrating, relative density 1.20-1.25 when being concentrated into 60 ℃, drying, subsequent use; Get Fructus Jujubae, add decocting and boil secondary, each 2h filters; Merge secondary filtrating, relative density 1.28-1.32 when being concentrated into 60 ℃, drying, with the above-mentioned fine powder that is dried and crushed into,, subsequent use with Semen Crotonis Pulveratum, Moschus mixing; Add 12 ‰ magnesium stearate, mixing, compacting promptly gets in flakes.
Embodiment 24
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 250g, Lignum Aquilariae Resinatum 400g, Fructus Aurantii 400g, Lignum Santali Albi 250g, Radix Et Rhizoma Rhei 250g, Cortex Magnoliae Officinalis 400g, Moschus 12g, Semen Crotonis Pulveratum 150g, Fructus Jujubae 1200g, Rhizoma Chuanxiong 250g, Rhizoma Atractylodis Macrocephalae 400g and Rhizoma Coptidis 300g are subsequent use;
B. above crude drug, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is subsequent use; All the other Radix Aucklandiae, Lignum Aquilariae Resinatum, Fructus Aurantii, Lignum Santali Albi, Radix Et Rhizoma Rhei, Cortex Magnoliae Officinalis etc. are ground into coarse powder, add 16 times of water gagings, soak 4 hours, and decocting boils distillation 8h altogether, collects volatile oil, and is after β-CD inclusion, subsequent use; Decocting liquid filters, and relative density 1.25-1.30 was subsequent use when filtrating was concentrated into 60 ℃, and medicinal residues and Lignum Santali Albi coarse powder add 70% alcohol reflux 2 times, for the first time 2h; 1h filters for the second time; Merge secondary filtrating, relative density 1.20-1.25 when being concentrated into 60 ℃, drying, subsequent use; Get Fructus Jujubae, add decocting and boil secondary, each 2h filters; Merge secondary filtrating, relative density 1.28-1.32 when being concentrated into 60 ℃, drying, with the above-mentioned fine powder that is dried and crushed into,, subsequent use with Semen Crotonis Pulveratum, Moschus mixing; Add 6 ‰ magnesium stearate, mixing is pressed into 33000, promptly gets.
Embodiment 25
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 250g, Lignum Aquilariae Resinatum 250g, Fructus Aurantii 250g, Lignum Santali Albi 150g, Radix Et Rhizoma Rhei 150g, Cortex Magnoliae Officinalis 250g, Moschus 6g, Semen Crotonis Pulveratum 100g, Fructus Jujubae 800g, Rhizoma Chuanxiong 150g, Radix Codonopsis 250g, Poria 250g, Rhizoma Atractylodis Macrocephalae 250g and Rhizoma Coptidis 150g are subsequent use;
B. above crude drug, Semen Crotonis Pulveratum, Moschus pulverize separately become fine powder; All the other crude drug decocte with water 2 times, each 2 hours, collecting decoction filtered, and is condensed into thick paste; In above-mentioned thick paste, add Semen Crotonis Pulveratum, Moschus powder, mixing, subsequent use; It is an amount of to add vegetable oil, and mixing is processed soft capsule, promptly gets.
Embodiment 26
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 400g, Lignum Aquilariae Resinatum 400g, Fructus Aurantii 400g, Lignum Santali Albi 250g, Radix Et Rhizoma Rhei 250g, Cortex Magnoliae Officinalis 400g, Moschus 12g, Semen Crotonis Pulveratum 150g, Fructus Jujubae 1200g, Rhizoma Chuanxiong 250g, Radix Codonopsis 400g, Poria 400g, Rhizoma Atractylodis Macrocephalae 400g and Rhizoma Coptidis 300g are subsequent use;
B. above crude drug, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is subsequent use; All the other Radix Aucklandiae, Lignum Aquilariae Resinatum, Fructus Aurantii, Lignum Santali Albi, Radix Et Rhizoma Rhei, Cortex Magnoliae Officinalis etc. are ground into coarse powder, add 12 times of water gagings, soak 4 hours, and decocting boils distillation 8h altogether, collects volatile oil, and is after β-CD inclusion, subsequent use; Decocting liquid filters, and relative density 1.25-1.30 was subsequent use when filtrating was concentrated into 60 ℃, and medicinal residues and Lignum Santali Albi coarse powder add 70% alcohol reflux 2 times, for the first time 2h; 1h filters for the second time; Merge secondary filtrating, relative density 1.20-1.25 when being concentrated into 60 ℃, drying, subsequent use; Get Fructus Jujubae, add decocting and boil secondary, each 2h filters; Merge secondary filtrating, relative density 1.28-1.32 when being concentrated into 60 ℃, drying, with the above-mentioned fine powder that is dried and crushed into,, subsequent use with Semen Crotonis Pulveratum, Moschus mixing; It is an amount of to add vegetable oil, and mixing is processed soft capsule, promptly gets.
Embodiment 27
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 250g, Lignum Aquilariae Resinatum 250g, Fructus Aurantii 250g, Lignum Santali Albi 150g, Radix Et Rhizoma Rhei 150g, Cortex Magnoliae Officinalis 250g, Moschus 6g, Semen Crotonis Pulveratum 100g, Rhizoma Chuanxiong 150g, Seem Lablab Album 250g and Rhizoma Dioscoreae 250g are subsequent use;
B. above crude drug, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is subsequent use; All the other Radix Aucklandiae, Lignum Aquilariae Resinatum, Fructus Aurantii, Lignum Santali Albi, Radix Et Rhizoma Rhei, Cortex Magnoliae Officinalis etc. are ground into 50 purpose powder, CO 2Supercritical extraction, extracting pressure 17MPa, 40 ℃ of temperature, CO 2Flow velocity 25L/h, extraction 3h; Get extract, add an amount of anhydrous alcohol solution,, adopt polishing to carry out enclose,, promptly get clathrate in 40 ℃ of vacuum dryings with an amount of β-CD, subsequent use; Medicinal residues behind the above-mentioned supercritical extraction are added 60% ethanol extraction secondary, merge secondary filtrating, relative density is that 1.25-1.30 is subsequent use when reclaiming ethanol to 60 ℃; Clathrate, Semen Crotonis Pulveratum, the Moschus mixing that sieves is crossed 80 mesh sieves, and is subsequent use; It is an amount of to add vegetable oil, processes 36000 soft capsules, promptly gets.
Embodiment 28
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 400g, Lignum Aquilariae Resinatum 400g, Fructus Aurantii 400g, Lignum Santali Albi 250g, Radix Et Rhizoma Rhei 250g, Cortex Magnoliae Officinalis 400g, Moschus 12g, Semen Crotonis Pulveratum 150g, Rhizoma Chuanxiong 250g, Seem Lablab Album 400g and Rhizoma Dioscoreae 400g are subsequent use;
B. above crude drug, Semen Crotonis Pulveratum, Moschus pulverize separately become fine powder; All the other crude drug decocte with water 2 times, each 2 hours, collecting decoction filtered, and is condensed into thick paste; In above-mentioned thick paste, add Semen Crotonis Pulveratum, Moschus powder, mixing, subsequent use; It is an amount of to add vegetable oil, and mixing is processed soft capsule, promptly gets.
Embodiment 29
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 250g, Lignum Aquilariae Resinatum 250g, Fructus Aurantii 250g, Lignum Santali Albi 150g, Radix Et Rhizoma Rhei 150g, Cortex Magnoliae Officinalis 250g, Moschus 6g, Semen Crotonis Pulveratum 100g, Fructus Jujubae 800g, Rhizoma Chuanxiong 150～250g, Semen Arecae 120g and Fructus Crataegi 250g are subsequent use;
B. Semen Crotonis Pulveratum, Moschus pulverize separately become fine powder; All the other Radix Aucklandiae, Lignum Aquilariae Resinatum, Fructus Aurantii, Lignum Santali Albi, Radix Et Rhizoma Rhei, Cortex Magnoliae Officinalis etc. are ground into fine powder; With Semen Crotonis Pulveratum, Moschus powder facing-up, mixing sieves; Get above-mentioned hybrid medicine powder 569g, add glycerol 6000g, Al (OH) 380g, PAA 1500g mix homogeneously is component A; Get tartaric acid 40g, add distilled water 13500g, acrylate copolymer 800g, dissolving is B component; B component slowly adds among the component A, stirs, and is coated with, and is compound with protecting film, cuts promptly to get.
Embodiment 30
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 400g, Lignum Aquilariae Resinatum 400g, Fructus Aurantii 400g, Lignum Santali Albi 250g, Radix Et Rhizoma Rhei 250g, Cortex Magnoliae Officinalis 400g, Moschus 12g, Semen Crotonis Pulveratum 150g, Fructus Jujubae 1200g, Rhizoma Chuanxiong 250g, Semen Arecae 250g and Fructus Crataegi 400g are subsequent use;
B. above crude drug, Semen Crotonis Pulveratum, Moschus pulverize separately become fine powder; All the other crude drug decocte with water 2 times, each 2 hours, collecting decoction filters, and is condensed into thick paste, and was subsequent use; Taking polyethylene glycol 6000: the mixture Polyethylene Glycol of Macrogol 4000=3: 2 is an amount of, and heating makes fusion, adds above-mentioned thick paste and Semen Crotonis Pulveratum, Moschus powder; Mixing, adopt dripping speed is 50～60/min, splashes into methyl-silicone oil: in the condensed fluid of liquid Paraffin=4: 1; Promptly get drop pill, promptly get.
Embodiment 31
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 250g, Lignum Aquilariae Resinatum 250g, Fructus Aurantii 250g, Lignum Santali Albi 150～g, Radix Et Rhizoma Rhei 150g, Cortex Magnoliae Officinalis 250g, Moschus 6g, Semen Crotonis Pulveratum 100g, Fructus Jujubae 800g, Rhizoma Chuanxiong 150g, Poria 250g and JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata) 250g are subsequent use;
B. above crude drug, Semen Crotonis Pulveratum, Moschus pulverize separately become fine powder; All the other crude drug decocte with water 2 times, each 2 hours, collecting decoction filters, and is condensed into thick paste, and was subsequent use; Taking polyethylene glycol 6000: the mixture Polyethylene Glycol of Macrogol 4000=5: 2 is an amount of, and heating makes fusion, adds above-mentioned thick paste and Semen Crotonis Pulveratum, Moschus powder; Mixing, adopt dripping speed is 55～60/min, splashes into methyl-silicone oil: in the condensed fluid of liquid Paraffin=3: 1; Promptly get drop pill, promptly get.
Embodiment 32
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 400g, Lignum Aquilariae Resinatum 400g, Fructus Aurantii 400g, Lignum Santali Albi 250g, Radix Et Rhizoma Rhei 250g, Cortex Magnoliae Officinalis 400g, Moschus 12g, Semen Crotonis Pulveratum 150g, Fructus Jujubae 1200g, Rhizoma Chuanxiong 250g, Poria 400g and JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata) 400g are subsequent use;
B. above crude drug, Semen Crotonis Pulveratum, Moschus pulverize separately become fine powder; All the other eight flavor medicine decocte with water 2 times, each 2 hours, collecting decoction filtered, and is condensed into thick paste; In above-mentioned thick paste, add Semen Crotonis Pulveratum, Moschus powder, mixing, subsequent use; Get above-mentioned hybrid medicine powder 1800g, add glycerol 8000g, Al (OH) 345g, PAA 2000g mix homogeneously is component A; Get tartaric acid 90g, add distilled water 27000g, acrylate copolymer 1800g, dissolving is B component; B component slowly adds among the component A, stirs, and is coated with, and is compound with protecting film, cuts promptly to get.
Embodiment 33
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 250g, Lignum Aquilariae Resinatum 250g, Fructus Aurantii 250g, Lignum Santali Albi 150g, Radix Et Rhizoma Rhei 150g, Cortex Magnoliae Officinalis 250g, Moschus 6g, Semen Crotonis Pulveratum 100g, Fructus Jujubae 800g, Rhizoma Chuanxiong 150g, Endothelium Corneum Gigeriae Galli 120g, JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata) 250g and Pericarpium Citri Reticulatae 150g are subsequent use;
B. above crude drug, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is subsequent use; Pulverizing such as all the other Radix Aucklandiae, Lignum Aquilariae Resinatum, Fructus Aurantii, Lignum Santali Albi, Radix Et Rhizoma Rhei, Cortex Magnoliae Officinalis, CO 2Supercritical extraction; Get extract, add an amount of anhydrous alcohol solution, carry out enclose with an amount of β-CD, drying promptly gets clathrate, and is subsequent use; With the medicinal residues ethanol extraction secondary behind the above-mentioned supercritical extraction, merge secondary filtrating, reclaim ethanol and concentrate subsequent use; Get Fructus Jujubae decocte with water secondary, filter; Merging filtrate concentrates, and with above-mentioned alcohol extract condensed cream mixing, drying is ground into fine powder, with clathrate, Semen Crotonis Pulveratum, the Moschus mixing that sieves, sieves again, and is subsequent use, encapsulated, promptly gets.
Embodiment 34
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 400g, Lignum Aquilariae Resinatum 400g, Fructus Aurantii 400g, Lignum Santali Albi 250g, Radix Et Rhizoma Rhei 250g, Cortex Magnoliae Officinalis 400g, Moschus 12g, Semen Crotonis Pulveratum 150g, Fructus Jujubae 1200g, Rhizoma Chuanxiong 250g, Endothelium Corneum Gigeriae Galli 50g, JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata) 400g and Pericarpium Citri Reticulatae 150～600g are subsequent use;
B. above crude drug, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is subsequent use; Pulverizing such as all the other Radix Aucklandiae, Lignum Aquilariae Resinatum, Fructus Aurantii, Lignum Santali Albi, Radix Et Rhizoma Rhei, Cortex Magnoliae Officinalis, CO 2Supercritical extraction; Get extract, add an amount of anhydrous alcohol solution, carry out enclose with an amount of β-CD, drying promptly gets clathrate, and is subsequent use; With the medicinal residues ethanol extraction secondary behind the above-mentioned supercritical extraction, merge secondary filtrating, reclaim ethanol and concentrate subsequent use; Get Fructus Jujubae decocte with water secondary, filter; Merging filtrate concentrates, and with above-mentioned alcohol extract condensed cream mixing, drying is ground into fine powder, with clathrate, Semen Crotonis Pulveratum, the Moschus mixing that sieves, sieves again, and is subsequent use, encapsulated, promptly gets.
Embodiment 35
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 250g, Lignum Aquilariae Resinatum 250g, Fructus Aurantii 250g, Lignum Santali Albi 150g, Radix Et Rhizoma Rhei 150g, Cortex Magnoliae Officinalis 250g, Moschus 6g, Semen Crotonis Pulveratum 100g, Fructus Jujubae 800g, Rhizoma Chuanxiong 150g, Radix Angelicae Sinensis 120g is subsequent use;
B. above crude drug, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is subsequent use; Pulverizing such as all the other Radix Aucklandiae, Lignum Aquilariae Resinatum, Fructus Aurantii, Lignum Santali Albi, Radix Et Rhizoma Rhei, Cortex Magnoliae Officinalis, CO 2Supercritical extraction; Get extract, add an amount of anhydrous alcohol solution, carry out enclose with an amount of β-CD, drying promptly gets clathrate, and is subsequent use; With the medicinal residues ethanol extraction secondary behind the above-mentioned supercritical extraction, merge secondary filtrating, reclaim ethanol and concentrate subsequent use; Get Fructus Jujubae decocte with water secondary, filter; Merging filtrate concentrates, and with above-mentioned alcohol extract condensed cream mixing, drying is ground into fine powder, with clathrate, Semen Crotonis Pulveratum, the Moschus mixing that sieves, sieves again, and is subsequent use, encapsulated, promptly gets.
Embodiment 36
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 400g, Lignum Aquilariae Resinatum 400g, Fructus Aurantii 400g, Lignum Santali Albi 250g, Radix Et Rhizoma Rhei 250g, Cortex Magnoliae Officinalis 400g, Moschus 12g, Semen Crotonis Pulveratum 150g, Fructus Jujubae 1200g, Rhizoma Chuanxiong 250g, Radix Angelicae Sinensis 250g is subsequent use;
B. above crude drug, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is subsequent use; Pulverizing such as all the other Radix Aucklandiae, Lignum Aquilariae Resinatum, Fructus Aurantii, Lignum Santali Albi, Radix Et Rhizoma Rhei, Cortex Magnoliae Officinalis, CO 2Supercritical extraction; Get extract, add an amount of anhydrous alcohol solution, carry out enclose with an amount of β-CD, drying promptly gets clathrate, and is subsequent use; With the medicinal residues ethanol extraction secondary behind the above-mentioned supercritical extraction, merge secondary filtrating, reclaim ethanol and concentrate subsequent use; Get Fructus Jujubae decocte with water secondary, filter; Merging filtrate concentrates, and with above-mentioned alcohol extract condensed cream mixing, drying is ground into fine powder, with clathrate, Semen Crotonis Pulveratum, the Moschus mixing that sieves, sieves again, and is subsequent use, encapsulated, promptly gets.
Embodiment 37
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 250g, Lignum Aquilariae Resinatum 250g, Fructus Aurantii 250g, Lignum Santali Albi 150g, Radix Et Rhizoma Rhei 150g, Cortex Magnoliae Officinalis 250g, Moschus 6g, Semen Crotonis Pulveratum 100g, Fructus Jujubae 800g, Radix Paeoniae Alba 120g and Rhizoma Chuanxiong 150g are subsequent use;
B. above crude drug, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is subsequent use; All the other Radix Aucklandiae, Lignum Aquilariae Resinatum, Fructus Aurantii, Lignum Santali Albi, Radix Et Rhizoma Rhei, Cortex Magnoliae Officinalis etc. are ground into coarse powder, add 16 times of water gagings, soak 4 hours, and decocting boils distillation 8h altogether, collects volatile oil, and is after β-CD inclusion, subsequent use; Decocting liquid filters, and relative density 1.25-1.30 was subsequent use when filtrating was concentrated into 60 ℃, and medicinal residues and Lignum Santali Albi coarse powder add 70% alcohol reflux 2 times, for the first time 2h; 1h filters for the second time; Merge secondary filtrating, relative density 1.20-1.25 when being concentrated into 60 ℃, drying, subsequent use; Get Fructus Jujubae, add decocting and boil secondary, each 2h filters; Merge secondary filtrating, relative density 1.28-1.32 when being concentrated into 60 ℃, drying, with the above-mentioned fine powder that is dried and crushed into,, subsequent use with Semen Crotonis Pulveratum, Moschus mixing; Get carbomer 88g, add water 10000g and stir, NaOH regulates pH to 7, adds above-mentioned hybrid medicine powder 2500g, grinds evenly, promptly gets.
Embodiment 38
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 400g, Lignum Aquilariae Resinatum 400g, Fructus Aurantii 400g, Lignum Santali Albi 250g, Radix Et Rhizoma Rhei 250g, Cortex Magnoliae Officinalis 400g, Moschus 12g, Semen Crotonis Pulveratum 150g, Fructus Jujubae 1200g, Radix Paeoniae Alba 250g and Rhizoma Chuanxiong 250g are subsequent use;
B. above crude drug, Semen Crotonis Pulveratum, Moschus pulverize separately become fine powder; All the other crude drug decocte with water 2 times, each 2 hours, collecting decoction filtered, and is condensed into thick paste; In above-mentioned thick paste, add Semen Crotonis Pulveratum, Moschus powder, mixing, subsequent use; Get carbomer 85g, add water 7500g and stir, NaOH regulates pH to 7, adds above-mentioned hybrid medicine powder 2059g, grinds evenly, promptly gets.
Embodiment 39
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 250g, Lignum Aquilariae Resinatum 250g, Fructus Aurantii 250g, Lignum Santali Albi 150g, Radix Et Rhizoma Rhei 150g, Cortex Magnoliae Officinalis 250g, Moschus 6g, Semen Crotonis Pulveratum 100g, Fructus Jujubae 800g, Rhizoma Chuanxiong 150g, Radix Scutellariae 250g and Rhizoma Coptidis 250g are subsequent use;
B. above crude drug, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is subsequent use; All the other Radix Aucklandiae, Lignum Aquilariae Resinatum, Fructus Aurantii, Lignum Santali Albi, Radix Et Rhizoma Rhei, Cortex Magnoliae Officinalis etc. are ground into 50 purpose powder, CO 2Supercritical extraction, extracting pressure 20MPa, 55 ℃ of temperature, CO 2Flow velocity 25L/h, extraction 3h; Get extract, add an amount of anhydrous alcohol solution,, adopt polishing to carry out enclose,, promptly get clathrate in 40 ℃ of vacuum dryings with an amount of β-CD, subsequent use; Medicinal residues behind the above-mentioned supercritical extraction are added 60% ethanol extraction secondary, merge secondary filtrating, relative density is that 1.25-1.30 is subsequent use when reclaiming ethanol to 60 ℃; Get Fructus Jujubae decocte with water secondary, each 2h filters; Merging filtrate, relative density 1.25-1.30 when being concentrated into 60 ℃, with above-mentioned alcohol extract condensed cream mixing, drying is ground into fine powder, with clathrate, Semen Crotonis Pulveratum, the Moschus mixing that sieves, crosses 80 mesh sieves again, and is subsequent use; Get carbomer 188g, add water 14000g and stir, NaOH regulates pH to 7, adds above-mentioned hybrid medicine powder 1800g, grinds evenly, promptly gets.
Embodiment 40
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 400g, Lignum Aquilariae Resinatum 400g, Fructus Aurantii 400g, Lignum Santali Albi 250g, Radix Et Rhizoma Rhei 250g, Cortex Magnoliae Officinalis 400g, Moschus 12g, Semen Crotonis Pulveratum 150g, Fructus Jujubae 1200g, Rhizoma Chuanxiong 250g, Radix Scutellariae 400g and Rhizoma Coptidis 400g are subsequent use;
B. above crude drug, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is subsequent use; All the other Radix Aucklandiae, Lignum Aquilariae Resinatum, Fructus Aurantii, Lignum Santali Albi, Radix Et Rhizoma Rhei, Cortex Magnoliae Officinalis etc. are ground into 40-80 purpose powder, CO 2Supercritical extraction, extracting pressure 15MPa, 40 ℃ of temperature, CO 2Flow velocity 22L/h, extraction 2.5h; Get extract, add an amount of anhydrous alcohol solution,, adopt polishing to carry out enclose,, promptly get clathrate in 40 ℃ of vacuum dryings with an amount of β-CD, subsequent use; Medicinal residues behind the above-mentioned supercritical extraction are added 60% ethanol extraction secondary, merge secondary filtrating, relative density is that 1.25-1.30 is subsequent use when reclaiming ethanol to 60 ℃; Get Fructus Jujubae decocte with water secondary, each 2h filters; Merging filtrate, relative density 1.25-1.30 when being concentrated into 60 ℃, with above-mentioned alcohol extract condensed cream mixing, drying is ground into fine powder, with clathrate, Semen Crotonis Pulveratum, the Moschus mixing that sieves, crosses 80 mesh sieves again, and is subsequent use; Get above-mentioned hybrid medicine powder 1000g, fat-soluble ointment base 4000g is heated to 60 ℃ of mix homogeneously, is stirred to room temperature, promptly gets.
Embodiment 41
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 300g, Lignum Aquilariae Resinatum 300g, Fructus Aurantii 300g, Lignum Santali Albi 180g, Radix Et Rhizoma Rhei 180g, Cortex Magnoliae Officinalis 300g, Moschus 9g, Semen Crotonis Pulveratum 120g, Fructus Jujubae 1000g, Rhizoma Chuanxiong 180g, Radix Codonopsis 300g and Rhizoma Coptidis 200g are subsequent use;
B. above crude drug, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is subsequent use; Pulverizing such as all the other Radix Aucklandiae, Lignum Aquilariae Resinatum, Fructus Aurantii, Lignum Santali Albi, Radix Et Rhizoma Rhei, Cortex Magnoliae Officinalis, CO 2Supercritical extraction; Get extract, add an amount of anhydrous alcohol solution, carry out enclose with an amount of β-CD, drying promptly gets clathrate, and is subsequent use; With the medicinal residues ethanol extraction secondary behind the above-mentioned supercritical extraction, merge secondary filtrating, reclaim ethanol and concentrate subsequent use; Get Fructus Jujubae decocte with water secondary, filter; Merging filtrate concentrates, and with above-mentioned alcohol extract condensed cream mixing, drying is ground into fine powder, with clathrate, Semen Crotonis Pulveratum, the Moschus mixing that sieves, sieves again, and is subsequent use, encapsulated, promptly gets.
Embodiment 42
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 300g, Lignum Aquilariae Resinatum 300g, Fructus Aurantii 300g, Lignum Santali Albi 180g, Radix Et Rhizoma Rhei 180g, Cortex Magnoliae Officinalis 300g, Moschus 9g, Semen Crotonis Pulveratum 120g, Fructus Jujubae 1000g, Rhizoma Chuanxiong 180g, Rhizoma Atractylodis Macrocephalae 300g and Rhizoma Coptidis 200g are subsequent use;
B. above crude drug, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is subsequent use; All the other Radix Aucklandiae, Lignum Aquilariae Resinatum, Fructus Aurantii, Lignum Santali Albi, Radix Et Rhizoma Rhei, Cortex Magnoliae Officinalis etc. are ground into coarse powder, add water, soak, and decocting boils distillation, collect volatile oil, and be after β-CD inclusion, subsequent use; Decocting liquid filters, and filtrating concentrates subsequent use, and medicinal residues and Lignum Santali Albi coarse powder add alcohol reflux 2 times, filters; Merge secondary filtrating, concentrate, drying, subsequent use; Get Fructus Jujubae, add decocting and boil secondary, filter; Merge secondary filtrating, concentrate, drying, the above-mentioned fine powder that is dried and crushed into, subsequent use, encapsulated with Semen Crotonis Pulveratum, Moschus mixing, promptly get.
Embodiment 43
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 300g, Lignum Aquilariae Resinatum 300g, Fructus Aurantii 300g, Lignum Santali Albi 180g, Radix Et Rhizoma Rhei 180g, Cortex Magnoliae Officinalis 300g, Moschus 9g, Semen Crotonis Pulveratum 120g, Fructus Jujubae 1000g, Rhizoma Chuanxiong 180g, Radix Codonopsis 300g, Poria 300g, Rhizoma Atractylodis Macrocephalae 300g and Rhizoma Coptidis 200g are subsequent use;
B. above crude drug, Semen Crotonis Pulveratum, Moschus pulverize separately become fine powder; All the other crude drug decocte with water 3 times, each 1 hour, collecting decoction filtered, and is condensed into thick paste; In above-mentioned thick paste, add Semen Crotonis Pulveratum, Moschus powder, mixing, subsequent use, encapsulated, promptly get.
Embodiment 44
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 300g, Lignum Aquilariae Resinatum 300g, Fructus Aurantii 300g, Lignum Santali Albi 180g, Radix Et Rhizoma Rhei 180g, Cortex Magnoliae Officinalis 300g, Moschus 9g, Semen Crotonis Pulveratum 120g, Rhizoma Chuanxiong 180g, Seem Lablab Album 300g and Rhizoma Dioscoreae 300g are subsequent use;
B. go up ten flavors, Semen Crotonis Pulveratum, Moschus pulverize separately become fine powder; All the other crude drug decocte with water 2 times, each 3 hours, collecting decoction filtered, and is condensed into thick paste; In above-mentioned thick paste, add Semen Crotonis Pulveratum, Moschus powder, mixing, subsequent use; Encapsulated, promptly get.
Embodiment 45
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 300g, Lignum Aquilariae Resinatum 300g, Fructus Aurantii 300g, Lignum Santali Albi 180g, Radix Et Rhizoma Rhei 180g, Cortex Magnoliae Officinalis 300g, Moschus 9g, Semen Crotonis Pulveratum 120g, Fructus Jujubae 1000g, Rhizoma Chuanxiong 180g, Semen Arecae 180g and Fructus Crataegi 300g are subsequent use;
B. above crude drug, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is subsequent use; All the other Radix Aucklandiae, Lignum Aquilariae Resinatum, Fructus Aurantii, Lignum Santali Albi, Radix Et Rhizoma Rhei, Cortex Magnoliae Officinalis etc. are ground into 80 purpose powder, CO 2Supercritical extraction, extracting pressure 40MPa, 60 ℃ of temperature, CO 2Flow velocity 35L/h, extraction 5h; Get extract, add an amount of anhydrous alcohol solution,, adopt polishing to carry out enclose,, promptly get clathrate in 40 ℃ of vacuum dryings with an amount of β-CD, subsequent use; Medicinal residues behind the above-mentioned supercritical extraction are added 60% ethanol extraction secondary, merge secondary filtrating, relative density is that 1.25-1.30 is subsequent use when reclaiming ethanol to 60 ℃; Get Fructus Jujubae decocte with water secondary, each 2h filters; Merging filtrate, relative density 1.25-1.30 when being concentrated into 60 ℃, with above-mentioned alcohol extract condensed cream mixing, drying is ground into fine powder, with clathrate, Semen Crotonis Pulveratum, the Moschus mixing that sieves, crosses 80 mesh sieves again, and is subsequent use; Encapsulated, promptly get.
Embodiment 46
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 300g, Lignum Aquilariae Resinatum 300g, Fructus Aurantii 300g, Lignum Santali Albi 180g, Radix Et Rhizoma Rhei 180g, Cortex Magnoliae Officinalis 300g, Moschus 9g, Semen Crotonis Pulveratum 120g, Fructus Jujubae 1000g, Rhizoma Chuanxiong 180g, Poria 300g and JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata) 300g are subsequent use;
B. above crude drug, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is subsequent use; All the other Radix Aucklandiae, Lignum Aquilariae Resinatum, Fructus Aurantii, Lignum Santali Albi, Radix Et Rhizoma Rhei, Cortex Magnoliae Officinalis etc. are ground into coarse powder, add 16 times of water gagings, soak 4 hours, and decocting boils distillation 8h altogether, collects volatile oil, and is after β-CD inclusion, subsequent use; Decocting liquid filters, and relative density 1.25-1.30 was subsequent use when filtrating was concentrated into 60 ℃, and medicinal residues and Lignum Santali Albi coarse powder add 70% alcohol reflux 2 times, for the first time 2h; 1h filters for the second time; Merge secondary filtrating, relative density 1.20-1.25 when being concentrated into 60 ℃, drying, subsequent use; Get Fructus Jujubae, add decocting and boil secondary, each 2h filters; Merge secondary filtrating, relative density 1.28-1.32 when being concentrated into 60 ℃, drying, subsequent use with the above-mentioned fine powder that is dried and crushed into Semen Crotonis Pulveratum, Moschus mixing, add appropriate amount of auxiliary materials, process 36000 capsules, promptly get.
Embodiment 47
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 300g, Lignum Aquilariae Resinatum 300g, Fructus Aurantii 300g, Lignum Santali Albi 180g, Radix Et Rhizoma Rhei 180g, Cortex Magnoliae Officinalis 300g, Moschus 9g, Semen Crotonis Pulveratum 120g, Fructus Jujubae 1000g, Rhizoma Chuanxiong 180g, Endothelium Corneum Gigeriae Galli 180g, JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata) 300g and Pericarpium Citri Reticulatae 300g are subsequent use;
B. above crude drug, Semen Crotonis Pulveratum, Moschus pulverize separately become fine powder; All the other crude drug decocte with water 2 times, each 2 hours, collecting decoction filtered, and is condensed into thick paste; In above-mentioned thick paste, add Semen Crotonis Pulveratum, Moschus powder, mixing, subsequent use; Add sodium carboxymethyl cellulose, Icing Sugar, mixing, the system granule sieves, and drying promptly gets.
Embodiment 48
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 300g, Lignum Aquilariae Resinatum 300g, Fructus Aurantii 300g, Lignum Santali Albi 180g, Radix Et Rhizoma Rhei 180g, Cortex Magnoliae Officinalis 300g, Moschus 9g, Semen Crotonis Pulveratum 120g, Fructus Jujubae 1000g, Rhizoma Chuanxiong 180g, Radix Angelicae Sinensis 180g is subsequent use;
B. above crude drug, Semen Crotonis Pulveratum, Moschus pulverize separately become fine powder; All the other crude drug decocte with water 2 times, each 2 hours, collecting decoction filtered, and is condensed into thick paste; In above-mentioned thick paste, add Semen Crotonis Pulveratum, Moschus powder, mixing, subsequent use; Add sodium carboxymethyl cellulose, Icing Sugar, mixing, the system granule sieves, and drying promptly gets.
Embodiment 49
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 300g, Lignum Aquilariae Resinatum 300g, Fructus Aurantii 300g, Lignum Santali Albi 180g, Radix Et Rhizoma Rhei 180g, Cortex Magnoliae Officinalis 300g, Moschus 9g, Semen Crotonis Pulveratum 120g, Fructus Jujubae 1000g, Radix Paeoniae Alba 180g and Rhizoma Chuanxiong 180g are subsequent use;
B. above crude drug, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is subsequent use; Pulverizing such as all the other Radix Aucklandiae, Lignum Aquilariae Resinatum, Fructus Aurantii, Lignum Santali Albi, Radix Et Rhizoma Rhei, Cortex Magnoliae Officinalis, CO 2Supercritical extraction; Get extract, add an amount of anhydrous alcohol solution, carry out enclose with an amount of β-CD, drying promptly gets clathrate, and is subsequent use; With the medicinal residues ethanol extraction secondary behind the above-mentioned supercritical extraction, merge secondary filtrating, reclaim ethanol and concentrate subsequent use; Get Fructus Jujubae decocte with water secondary, filter; Merging filtrate concentrates, and with above-mentioned alcohol extract condensed cream mixing, drying is ground into fine powder, with clathrate, Semen Crotonis Pulveratum, the Moschus mixing that sieves, sieves again, and is subsequent use; Add an amount of magnesium stearate, mixing, compacting promptly gets.
Embodiment 50
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 300g, Lignum Aquilariae Resinatum 300g, Fructus Aurantii 300g, Lignum Santali Albi 180g, Radix Et Rhizoma Rhei 180g, Cortex Magnoliae Officinalis 300g, Moschus 9g, Semen Crotonis Pulveratum 120g, Fructus Jujubae 1000g, Rhizoma Chuanxiong 180g, Radix Scutellariae 300g and Rhizoma Coptidis 300g are subsequent use;
B. above crude drug, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is subsequent use; All the other Radix Aucklandiae, Lignum Aquilariae Resinatum, Fructus Aurantii, Lignum Santali Albi, Radix Et Rhizoma Rhei, Cortex Magnoliae Officinalis etc. are ground into coarse powder, add water, soak, and decocting boils distillation, collect volatile oil, and be after β-CD inclusion, subsequent use; Decocting liquid filters, and filtrating concentrates subsequent use, and medicinal residues and Lignum Santali Albi coarse powder add alcohol reflux 2 times, filters; Merge secondary filtrating, concentrate, drying, subsequent use; Get Fructus Jujubae, add decocting and boil secondary, filter; Merge secondary filtrating, concentrate, drying, the above-mentioned fine powder that is dried and crushed into, with Semen Crotonis Pulveratum, Moschus mixing, subsequent use; Add an amount of magnesium stearate, mixing, compacting promptly gets.

Claims (10)

1. treatment gastrointestinal disease Chinese medicine composition is characterized in that, is to be processed by following weight proportioning crude drug:
The Radix Aucklandiae 150～600g, Lignum Aquilariae Resinatum 150～600g, Fructus Aurantii 150～600g, Lignum Santali Albi 90～360g; Radix Et Rhizoma Rhei 90～360g, Cortex Magnoliae Officinalis 150～600g, Moschus 4.5～18g, Semen Crotonis Pulveratum 60～240g; Fructus Jujubae 500～2000g, Rhizoma Chuanxiong 90～360g, Radix Scutellariae 150～600g and Rhizoma Coptidis 150～600g.
2. the said treatment gastrointestinal disease of claim 1 Chinese medicine composition is characterized in that, is by processing according to following weight proportioning crude drug: the Radix Aucklandiae 250～400g, Lignum Aquilariae Resinatum 250～400g; Fructus Aurantii 250～400g, Lignum Santali Albi 150～250g, Radix Et Rhizoma Rhei 150～250g; Cortex Magnoliae Officinalis 250～400g, Moschus 6～12g, Semen Crotonis Pulveratum 100～150g; Fructus Jujubae 800～1200g, Rhizoma Chuanxiong 150～250g, Radix Scutellariae 250～400g and Rhizoma Coptidis 250～400g.
3. the said treatment gastrointestinal disease of claim 2 Chinese medicine composition is by processing according to following weight proportioning crude drug:
Radix Aucklandiae 300g, Lignum Aquilariae Resinatum 300g, Fructus Aurantii 300g, Lignum Santali Albi 180g, Radix Et Rhizoma Rhei 180g, Cortex Magnoliae Officinalis 300g, Moschus 9g, Semen Crotonis Pulveratum 120g, Fructus Jujubae 1000g, Rhizoma Chuanxiong 180g, Radix Scutellariae 300g and Rhizoma Coptidis 300g.
4. the arbitrary said treatment gastrointestinal disease Chinese medicine composition of claim 1～3 is characterized in that Fructus Aurantii is a stir-baked Fructus Aurantii in bran; Cortex Magnoliae Officinalis is a Cortex Magnoliae Officinalis (processed with ginger), and Fructus Jujubae is the Fructus Jujubae of enucleation.
5. the method for preparing of the arbitrary said treatment gastrointestinal disease Chinese medicine composition of claim 1～3 is characterized in that:
A. getting the weight proportion crude drug, to prepare active component according to present conventional method for preparing subsequent use;
B. the active component that obtains is processed preparation.
6. the method for preparing of the said treatment gastrointestinal disease of claim 5 Chinese medicine composition, it is characterized in that: the preparation among the step b is tablet, granule, honey pill agent, watered pill, drop pill, hard capsule, soft capsule, patch, cataplasma, ointment, gel.
7. the application of the arbitrary said treatment gastrointestinal disease Chinese medicine composition of claim 1～3 in preparation treatment irritable bowel syndrome medicine.
8. the application of the arbitrary said treatment gastrointestinal disease Chinese medicine composition of claim 1～3 in preparation treatment acute diarrhea, bacillary dysentery, enteritis, lienteric diarrhea medicine.
9. the arbitrary said treatment gastrointestinal disease Chinese medicine composition of claim 1～3 is in preparation eliminating turbid pathogen with aromatics, regulating QI to relieve pain, the application in the consumer product dredge stasis medicine.
10. the arbitrary said treatment gastrointestinal disease Chinese medicine composition of claim 1～3 is in preparation invigorating the spleen to arrest diarrhea, the application in antidiarrheal dysentery relieving and the blood dysentery relieving medicine.
CN2011104033034A 2008-12-24 2008-12-24 Chinese medicinal composition for treating gastrointestinal disease and preparation method of Chinese medicinal composition Pending CN102416076A (en)

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Application publication date: 20120418