CN101757277B - Pharmaceutical composition for treating gastrointestinal diseases and preparation method thereof - Google Patents
Pharmaceutical composition for treating gastrointestinal diseases and preparation method thereof Download PDFInfo
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Abstract
The invention relates to a pharmaceutical composition for treating gastrointestinal diseases and a preparation method thereof. The pharmaceutical composition is prepared from tens of traditional Chinese herbs of costustoot, agilawood, fructus aurantii, sanders, rheum officinale, mangnolia officinalis, muak, defatted croton seed powder, date and ligusticum wallichii. The pharmaceutical composition is mainly used for treating diseases of acute diarrhea, irritable bowel syndrome and the like in clinic.
Description
Technical field
The present invention relates to field of medicaments, particularly relate to a kind of pharmaceutical composition of treating gastrointestinal disease and preparation method thereof.
Background technology
Diarrhoea can be divided into infectious and non-infectious two types.Infectious diarrhea is divided into bacterial infection and viral infection again; Noninfectious diarrhea then can be caused by the change of improper diet, food anaphylaxis, rule of life, abrupt change of climate even multiple reason such as nervous.Motherland's medical science thinks to have loose bowels and is meant that defecation frequency increases, feces is rare clearly, even like water sample.The major lesions of having loose bowels is taste and intestine and small intestine.Its pathogenesis has being invaded by exogenous pathogen, injury due to diet, seven emotions discord, damp internal resistance and internal organs weakness etc.The clinical findings damp is caused a disease has cold-damp and damp and hot branch.Spleen and stomach function expands, and to hinder be to be caused by multiple factor, has exopathogen influence, taste weakness itself, incoordination between the liver and spleen and kidney intestinal deficiency etc. all can cause spleen and stomach function not normal and have loose bowels.Survey data shows that diarrhoea sickness rate in urban population reaches 0.4 time/people, and the rural population sickness rate reaches 0.5 time/people.Though diarrhoea is minor illness, pathogenic factor also is diversified, and changes with epoch, environment.We can say that the diarrhoea of today and the diarrhoea before 20 years see that from pathogeny the change of essence has been arranged.Along with development of times, people's living standard attains the well-off standard basically, and sanitary condition is improved greatly; Diarrhoea ratio by bacterial infection causes is fewer and feweri, on the contrary, because rhythm of life is accelerated; Struggle for existence is fierce, and the functional diarrhea ratio that pressure causes greatly obviously rises.A research shows that the diarrhoeal diseases people of China about 30% needs antibiosis usually to treat, and 70% does not need should not use antibiotic therapy yet.Consumer also more and more notices the untoward reaction of products such as berberine, norfloxacin, and the harm that abuse of antibiotics brought.Diarrhoea market is except low side antibiotic products such as berberine, norfloxacin; Some non-antibiotic products have also been introduced in recent years; Close such as thinking: as to reach, Birid Triple Viable etc.; But be positioned at high-end consumer groups, for most of consumer groups, its price positioning does not conform to the consumption location of such minor illness of suffering from diarrhoea with consumer.Analysis expert thinks, urban market diarrhoea mainly be with viral be main, be main in the rural area with bacterial infection, if according to the principle of the market segments, at present a lot of products all are difficult to cover the whole market.For alteration of intestinal flora person, available little ecological active bacteria formulation provides probiotics, improves intestinal environment, improves intestinal absorption, kinestate.As: bifidobacteria viable bacteria preparation (the happy capsule of beautiful pearl intestinal), Birid Triple Viable capsule, bacillus cicheniformis (whole intestinal rubber capsule); The intestinal mucosa protective agent: two eight body Montmorillonitums (dioctahedral smectite), the protection intestinal mucosa can suppress fixedly mycin, promotes the intestinal mucosal lesion reparation; Contain the creosote component preparation: the excessive secretion that can suppress intestinal juice.
At present on the market gastrointestinal disease treating pill is mainly used in the diarrhoea that the treatment dyspepsia causes, enteritis, and bacillary dysentery, distension and fullness in the abdomen, stomachache, the food stagnation infantile dyspepsia, its pharmacological action is higher than like product: diarrhea, antibiotic, antiviral, four kinds of functions of adjusting gastrointestinal function are also deposited.But contain Cinnabaris in its prescription; Its effect is a tranquillizing the mind by relieving convulsion; But contain hydrargyrum in the Cinnabaris; Hydrargyrum is very big to the harm of human body, and it is the process of a subtle lasting absorption, and human body contacts hydrargyrum for a long time can cause chronic poisoning: nerve, digestion, hormonal system and kidney to the people produce harm; Neurasthenic crowd may cause symptoms such as headache, dizziness, insomnia, hypomnesis, malaise; And anemia of pregnant woman and the women of age of sucking contact hydrargyrum for a long time, also possibly endanger fetus and baby's health.Mercurous in addition medicine has received certain restriction when exporting other countries, require mercury content to require then strict more for some European countries less than 0.5ppm like Singapore.Secondly, pill remains in certain shortcoming, if any taking dose big, child administration difficulty especially; Production procedure is long, and opportunities for contamination is many, and misoperation influences disintegrate and curative effect.Drop pill is a kind of pharmaceutical dosage form of quick acting, is fit to various types of patients.
Summary of the invention
The purpose of this invention is to provide a kind of pharmaceutical composition of treating gastrointestinal disease.
Another object of the present invention provides a kind of preparation of drug combination method of treating gastrointestinal disease.
The pharmaceutical composition that the present invention treats gastrointestinal disease is to be processed by the Radix Aucklandiae, Lignum Aquilariae Resinatum, Fructus Aurantii, Lignum Santali Albi, Radix Et Rhizoma Rhei, Cortex Magnoliae Officinalis, Moschus, Semen Crotonis Pulveratum, Fructus Jujubae, Rhizoma Chuanxiong ten flavor flavour of a drug.Pharmaceutical composition of the present invention has been selected Lignum Aquilariae Resinatum, Lignum Santali Albi, Radix Aucklandiae removing dampness by means of aromatics, regulating QI to relieve pain, non-return, the invigorating the spleen to arrest diarrhea of sending down the abnormal ascending QI for use to the pathogeny of having loose bowels.Wherein Lignum Aquilariae Resinatum sending down the abnormal ascending QI, Lignum Santali Albi rise gas, the Radix Aucklandiae is longer than the stagnant gas of capable the intestines and stomach.Three medicine mutual reinforcements between are for using stasis, promoting the circulation of QI to relieve pain, reason spleen antidiarrheal, removing dampness by means of aromatics, the expelling cold to relieve vomiting of function of spleen and stomach regulating intestine and small intestine effectively.Be aided with Fructus Aurantii, Cortex Magnoliae Officinalis, the painful abdominal mass removing dampness that disappears of regulating the flow of vital energy is loose long-pendingly, and intestinal stasis relieving helps digestion, and is equipped with gas medicine in the Rhizoma Chuanxiong fortune blood with blood-activating and qi-promoting.The six hollow viscera must keep its unobstructed, also the disease of having loose bowels itself also is a kind of function of human body self-protection.Invade as pathogenic factor, blindness antidiarrheal was closed door and is stayed Kou Zhiyu when dyspepsia was stagnated, so we have selected for use Radix Et Rhizoma Rhei, Semen Crotonis Pulveratum with stasis removing; Radix Et Rhizoma Rhei bitter cold, Semen Crotonis Pulveratum are hot; Two medicine fit applications have promptly been avoided the too numbness of cold and heat, have strengthened stasis removing again and have removed evil malicious the stagnating of delaying at enteral.This treating incontinent symptoms (pseudomorph) by dredging method reach the purpose that toxin expelling antidiarrheal is not stayed poison from method of treatment.This also is our most important character.Be equipped with the Fructus Jujubae spleen reinforcing, relax the property of medicine.All medicines share, with reach eliminating turbid pathogen with aromatics, regulating QI to relieve pain, the effect of the intestinal stasis relieving that is good for the stomach, with the treatment turbid damp obstructing in middle-JIAO, the diarrhoea due to dyspepsia is not changed, poor appetite, feel sick, diseases such as vomiting, abdominal distention, stomachache, dyspepsia, enteritis, bacillary dysentery, viral diarrhea.
The present invention treats the pharmaceutical composition of gastrointestinal disease, can adopt following method to prepare active component for crude drug: like one or several Combined application preparations in extraction, water extraction, decoction and alcohol sedimentation technique, extraction, infusion process, percolation, reflux extraction, continuous backflow extraction method, the macroreticular resin absorbing method.But in order to make each crude drug of this medicine bring into play drug effect better, the present invention preferably adopts following technology to extract active component to raw material, and processes the pharmaceutical composition that the present invention treats gastrointestinal disease, but this can not limit protection scope of the present invention.
The present invention treats the pharmaceutical composition of gastrointestinal disease, and employing is prepared as follows method and processes:
A. take off column weight amount proportioning crude drug: the Radix Aucklandiae 150～600g, Lignum Aquilariae Resinatum 150～600g, Fructus Aurantii 150～600g, Lignum Santali Albi 90～360g, Radix Et Rhizoma Rhei 90～360g, Cortex Magnoliae Officinalis 150～600g, Moschus 4.5～18g, Semen Crotonis Pulveratum 60～240g, Fructus Jujubae 500～2000g, Rhizoma Chuanxiong 90～360g are subsequent use;
B. get the Radix Aucklandiae, Lignum Aquilariae Resinatum, Lignum Santali Albi, Fructus Aurantii, Cortex Magnoliae Officinalis, Rhizoma Chuanxiong, Radix Et Rhizoma Rhei powder and be broken into coarse powder, add alcohol reflux, extracting solution is concentrated into clear paste, and is subsequent use; Get Fructus Jujubae, add decocting and boil, decoction liquor is concentrated into clear paste, and is subsequent use; With above-mentioned gained clear paste drying under reduced pressure, get dry extract, dried cream powder is broken into fine powder and Semen Crotonis Pulveratum, the Moschus mixing that sieves, sieve, active component is subsequent use;
C. above-mentioned active component is processed pharmaceutical preparation.
The present invention preferably treats the pharmaceutical composition of gastrointestinal disease, and employing is prepared as follows method and processes:
A. take off column weight amount proportioning crude drug: the Radix Aucklandiae 250～400g, Lignum Aquilariae Resinatum 250～400g, Fructus Aurantii 250～400g, Lignum Santali Albi 150～250g, Radix Et Rhizoma Rhei 150～250g, Cortex Magnoliae Officinalis 250～400g, Moschus 6～12g, Semen Crotonis Pulveratum 100～150g, Fructus Jujubae 800～1200g, Rhizoma Chuanxiong 150～250g are subsequent use;
B. get the Radix Aucklandiae, Lignum Aquilariae Resinatum, Lignum Santali Albi, Fructus Aurantii, Cortex Magnoliae Officinalis, Rhizoma Chuanxiong, Radix Et Rhizoma Rhei powder and be broken into coarse powder; Add 40～90% alcohol reflux 2～3 times, each 3～12 times of amounts of alcohol adding amount refluxed 0.5～4 hour; Filter; Merging filtrate, the clear paste of relative density 1.05-1.45 is subsequent use when under 40-85 ℃, being concentrated into 40～80 ℃; Get Fructus Jujubae, add decocting and boil 2～3 times, add 4～12 times of amounts of water at every turn, refluxed 0.5～4 hour, filter, merging filtrate, the clear paste of relative density 1.08-1.42 is subsequent use when under 40-95 ℃, being concentrated into 40～80 ℃; With above-mentioned gained clear paste drying under reduced pressure, get dry extract, dried cream powder is broken into fine powder and Semen Crotonis Pulveratum, the Moschus mixing that sieves, sieve, active component is subsequent use;
C. above-mentioned active component is processed pharmaceutical preparation.
The pharmaceutical composition of the further preferred treatment gastrointestinal disease of the present invention, employing is prepared as follows method and processes:
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 300g, Lignum Aquilariae Resinatum 300g, Fructus Aurantii 300g, Lignum Santali Albi 180g, Radix Et Rhizoma Rhei 180g, Cortex Magnoliae Officinalis 300g, Moschus 9g, Semen Crotonis Pulveratum 120g, Fructus Jujubae 1000g, Rhizoma Chuanxiong 180g are subsequent use;
B. get the Radix Aucklandiae, Lignum Aquilariae Resinatum, Lignum Santali Albi, Fructus Aurantii, Cortex Magnoliae Officinalis, Rhizoma Chuanxiong, Radix Et Rhizoma Rhei powder and be broken into coarse powder, add 80% alcohol reflux 2 times, 8 times of amounts of alcohol adding amount refluxed 2 hours for the first time; 6 times of amounts of alcohol adding amount refluxed 1 hour for the second time, filtered, and merged secondary filtrating, and the clear paste of relative density 1.25-1.30 is subsequent use when under 60-65 ℃, being concentrated into 60 ℃; Get Fructus Jujubae, add decocting and boil 2 times, add 10 times of amounts of water for the first time, refluxed 2 hours; For the second time add 8 times of amounts of water, refluxed 1 hour, filter, merge filtrating 2 times, the clear paste of relative density 1.28-1.32 is subsequent use when under 80-85 ℃, being concentrated into 60 ℃; With above-mentioned gained clear paste drying under reduced pressure, get dry extract, dried cream powder is broken into fine powder and Semen Crotonis Pulveratum, the Moschus mixing that sieves, and crosses 80 mesh sieves, active component is subsequent use;
C. above-mentioned active component is processed pharmaceutical preparation.
The present invention treats in the pharmaceutical composition of gastrointestinal disease, and the Fructus Aurantii among the step a is a stir-baked Fructus Aurantii in bran; Cortex Magnoliae Officinalis is a Cortex Magnoliae Officinalis (processed with ginger); Fructus Jujubae is that Fructus Jujubae, the Moschus of enucleation is the artificial Moschus.
The present invention treats the preparation of drug combination method of gastrointestinal disease, and step is following:
A. take off column weight amount proportioning crude drug: the Radix Aucklandiae 150～600g, Lignum Aquilariae Resinatum 150～600g, Fructus Aurantii 150～600g, Lignum Santali Albi 90～360g, Radix Et Rhizoma Rhei 90～360g, Cortex Magnoliae Officinalis 150～600g, Moschus 4.5～18g, Semen Crotonis Pulveratum 60～240g, Fructus Jujubae 500～2000g, Rhizoma Chuanxiong 90～360g are subsequent use;
B. get the Radix Aucklandiae, Lignum Aquilariae Resinatum, Lignum Santali Albi, Fructus Aurantii, Cortex Magnoliae Officinalis, Rhizoma Chuanxiong, Radix Et Rhizoma Rhei powder and be broken into coarse powder, add alcohol reflux, extracting solution is concentrated into clear paste, and is subsequent use; Get Fructus Jujubae, add decocting and boil, decoction liquor is concentrated into clear paste, and is subsequent use; With above-mentioned gained clear paste drying under reduced pressure, get dry extract, dried cream powder is broken into fine powder and Semen Crotonis Pulveratum, the Moschus mixing that sieves, sieve, active component is subsequent use;
C. above-mentioned active component is processed pharmaceutical preparation.
The present invention preferably treats the preparation of drug combination method of gastrointestinal disease, and step is following:
A. take off column weight amount proportioning crude drug: the Radix Aucklandiae 250～400g, Lignum Aquilariae Resinatum 250～400g, Fructus Aurantii 250～400g, Lignum Santali Albi 150～250g, Radix Et Rhizoma Rhei 150～250g, Cortex Magnoliae Officinalis 250～400g, Moschus 6～12g, Semen Crotonis Pulveratum 100～150g, Fructus Jujubae 800～1200g, Rhizoma Chuanxiong 150～250g are subsequent use;
B. get the Radix Aucklandiae, Lignum Aquilariae Resinatum, Lignum Santali Albi, Fructus Aurantii, Cortex Magnoliae Officinalis, Rhizoma Chuanxiong, Radix Et Rhizoma Rhei powder and be broken into coarse powder; Add 40～90% alcohol reflux 2～3 times, each 3～12 times of amounts of alcohol adding amount refluxed 0.5～4 hour; Filter; Merging filtrate, the clear paste of relative density 1.05-1.45 is subsequent use when under 40-85 ℃, being concentrated into 40～80 ℃; Get Fructus Jujubae, add decocting and boil 2～3 times, add 4～12 times of amounts of water at every turn, refluxed 0.5～4 hour, filter, merging filtrate, the clear paste of relative density 1.08-1.42 is subsequent use when under 40-95 ℃, being concentrated into 40～80 ℃; With above-mentioned gained clear paste drying under reduced pressure, get dry extract, dried cream powder is broken into fine powder and Semen Crotonis Pulveratum, the Moschus mixing that sieves, sieve, active component is subsequent use;
C. above-mentioned active component is processed pharmaceutical preparation.
The preparation of drug combination method of the further preferred treatment gastrointestinal disease of the present invention, step is following:
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 300g, Lignum Aquilariae Resinatum 300g, Fructus Aurantii 300g, Lignum Santali Albi 180g, Radix Et Rhizoma Rhei 180g, Cortex Magnoliae Officinalis 300g, Moschus 9g, Semen Crotonis Pulveratum 120g, Fructus Jujubae 1000g, Rhizoma Chuanxiong 180g are subsequent use;
B. get the Radix Aucklandiae, Lignum Aquilariae Resinatum, Lignum Santali Albi, Fructus Aurantii, Cortex Magnoliae Officinalis, Rhizoma Chuanxiong, Radix Et Rhizoma Rhei powder and be broken into coarse powder, add 80% alcohol reflux 2 times, 8 times of amounts of alcohol adding amount refluxed 2 hours for the first time; 6 times of amounts of alcohol adding amount refluxed 1 hour for the second time, filtered, and merged secondary filtrating, and the clear paste of relative density 1.25-1.30 is subsequent use when under 60-65 ℃, being concentrated into 60 ℃; Get Fructus Jujubae, add decocting and boil 2 times, add 10 times of amounts of water for the first time, refluxed 2 hours; For the second time add 8 times of amounts of water, refluxed 1 hour, filter, merge filtrating 2 times, the clear paste of relative density 1.28-1.32 is subsequent use when under 80-85 ℃, being concentrated into 60 ℃; With above-mentioned gained clear paste drying under reduced pressure, get dry extract, dried cream powder is broken into fine powder and Semen Crotonis Pulveratum, the Moschus mixing that sieves, and crosses 80 mesh sieves, active component is subsequent use;
C. above-mentioned active component is processed pharmaceutical preparation.
The preparation of drug combination method of the gastrointestinal disease of treatment described in the present invention is characterized in that described preparation is tablet, granule, capsule, pill, drop pill, soft capsule.
In the preparation process of pharmaceutical preparation of the present invention, the used adjuvant of various dosage forms is adjuvant commonly used and the dosage in the textbook.
The present invention treats the application of pharmaceutical composition in preparation treatment irritable bowel syndrome medicine of gastrointestinal disease.
The present invention treats the application of pharmaceutical composition in preparation treatment acute diarrhea, bacillary dysentery, enteritis, lienteric diarrhea medicine of gastrointestinal disease.
More than form when producing and to increase or to reduce according to corresponding ratio; Like large-scale production can be unit with kilogram or with the ton; Small-scale production can be unit with the gram also, and weight can increase or reduce, but the crude drug material weight proportion constant rate between each composition.
The pharmaceutical composition that the present invention treats gastrointestinal disease has short dissolve scattered time limit, makes drug effect faster, is the medicine that chronic gastroenteropathy is treated in a kind of onset faster.
In order to understand the present invention better, further set forth the beneficial effect of medicine of the present invention below through Drug therapy chronic gastrointestinal disease 78 routine clinical verification case summaries of the present invention.Below used medicine of the present invention prepares according to embodiment 6 methods in the test.
One, observational technique
(1) object of observation: this group case is the out-patient, and untreated or treatment be person more, comprises functional diarrhea, functional dyspepsia, and irritable bowel syndrome, chronic and infective diarrhea is the object of observation.
(2) diagnostic criteria
Adopt " Rome II standard in 1999 ", selected case meets the diagnostic criteria of functional diarrhea, functional dyspepsia, irritable bowel syndrome, chronic and infective diarrhea.All cases are got rid of stomach, duodenum, colon organic disease all through stomach, colon scope or X line barium examination.
(3) rejecting standard
1, organic digestive system disease person is arranged, like polyp, tumor etc.
2, Liver and kidney is arranged, endocrine, the serious protopathy person of immune system and blood system: diabetes, uremia, hepatopathy etc.
3, anemia of pregnant woman and women breast-feeding their children.
4, do not meet diagnostic criteria.
(4) symptom degree evaluation standard
With reference to " new Chinese medicine clinical guidance principle ": according to symptom light, in, severe remembers 1,2,3 fen respectively.
1, symptom scoring method:
(1) asymptomatic (-): remember 0 fen;
(2) slight (+): occur note 1 minute once in a while;
(3) moderate (++): note 2 minutes often occur;
(4) severe (+++): continue to exist note 3 minutes.
2, have loose bowels:
(1) the asymptomatic and soft change (-) that is shaped: every day, 1-2 note was 0 minute;
(2) slight (+): symptom is slight, does not influence live and work, can stand, and stool every day 2-3 time, mushy stool or Mucous Stool are remembered 1 fen;
(3) moderate (++): symptom is heavier, has influenced work, life, still can stand, and stool is the egg style, every day 4-5 time, or the Mucous Stool moderate is remembered 2 fens;
(4) severe (+++): serious symptom, hinder one's work and live, be difficult to stand, rare watery stool, every day is more than 6 times, or a large amount of notes of Mucous Stool 3 minutes.
3, the deciding degree standard of disease
(1) severe: the cardinal symptom integration=＞total mark 70%;
(2) moderate: 70% of 30%＜=cardinal symptom integration＜total mark;
(3) slight: 30% of cardinal symptom integration＜=total mark;
(5) curative effect determinate standard and statistical method
Reference " new Chinese medicine clinical guidance principle " is as standard.
1, curative effect determinate standard:
(1) cure: cardinal symptom disappears, and stool is shaped, and every day 1-2 time, therapeutic index is 100%;
(2) produce effects: main clinic symptoms disappears basically, times of defecation every day 2-3 time, 75%＜=therapeutic index＜100%;
(3) effective: main clinic symptoms takes a turn for the better, and stool shape and time number average take a favorable turn 30%＜=therapeutic index＜75%;
(4) invalid: main clinic symptoms does not have change, therapeutic index＜30%;
The total score value of cardinal symptom * 100% before curative effect of disease index=(the total score value of cardinal symptom before the treatment-total score value of treatment back cardinal symptom)/treatment.
2, individual event symptom therapeutic evaluation standard:
(1) cure: after finishing the course of treatment, transference cure;
(2) produce effects: after curative effect finished, the symptom classification reduced 2 grades;
(3) effective: after curative effect finished, the symptom classification reduced 1 grade;
(4) invalid: as not reach above-mentioned standard.
(6) observation index
1, health giving quality is observed:
(1) before the treatment, the variation of sings and symptoms in the course of treatment.
(2) every day times of defecation, amount.
(3) stool shape is just wait like bloody purulent stool, Mucous Stool and rare water.
(4) stool routine examination inspection: erythrocyte, leukocyte and pus cell quantity in the stool have or not indigestion dietary fiber, fat drop etc.
(5) the part patient does just and cultivates.
(6) the part patient does colonoscope, intestinal radiography, gastroscope.
3, safety is observed:
(1) blood, routine urianlysis.
(2) just routine test.
4, main clinic symptoms is observed:
(1) functional diarrhea: diarrhoea, with tenesmus, watery stool, Mucous Stool.
(2) functional dyspepsia: upper abdomen is glutted, morning is full, belch, Upper abdominal pain, nausea and vomiting, acid regurgitation.
(3) irritable bowel syndrome: stomachache, abdominal distention, diarrhoea, just not to the utmost, times of defecation, shape.
(4) chronic and infective diarrhea: diarrhoea, stomachache, tenesmus, the dense hemafecia of mucus.
Two, clinical data
Therapeutic Method
All the cases other treatment medicine of during medication, stopping using uses medicine of the present invention merely, usage and dosage be 3/inferior, 3 times/day, be 4 weeks the course of treatment.
Statistical method
Enumeration data is used X
2Check, measurement data are used the t check.
Observed result
1, each sick clinical treatment front and back total effects of planting is observed, and is as shown in table 1
Each sick clinical treatment front and back total effects table of planting of table 1
2, each sick clinical treatment front and back obvious effective rate comparable situation of planting is as shown in table 2
Each sick clinical treatment front and back obvious effective rate comparison sheet of planting of table 2
Four kinds of sick X
2Relatively, P＞0.05 not statistically significant explains that this medicine all has significant therapeutic effect to above-mentioned 4 kinds of diseases.
Three, the result shows
1, various chronic gastrointestinal disease had the good curing effect
Clinical effectiveness shows that the sick statistical effect of planting of each of Drug therapy chronic gastrointestinal disease of the present invention is learned there was no significant difference, and explaining all has good therapeutical effect to various chronic gastrointestinal disease.
2, has the obvious effect that improves chronic gastrointestinal disease patient clinical symptoms
Clinical effectiveness shows that medicine of the present invention is relieve clinical symptoms obviously.To single sick plant primary symptom to improve effect obvious, total effective rate is all more than 85%.
3, do not find apparent side effect during the medication.
The specific embodiment
Below further set forth the method for preparing of medicine of the present invention through embodiment.
Embodiment 1:
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 150g, Lignum Aquilariae Resinatum 150g, Fructus Aurantii 150g, Lignum Santali Albi 90g, Radix Et Rhizoma Rhei 90g, Cortex Magnoliae Officinalis 150g, Moschus 4.5g, Semen Crotonis Pulveratum 60g, Fructus Jujubae 500g, Rhizoma Chuanxiong 90g are subsequent use;
B. get the Radix Aucklandiae, Lignum Aquilariae Resinatum, Lignum Santali Albi, Fructus Aurantii, Cortex Magnoliae Officinalis, Rhizoma Chuanxiong, Radix Et Rhizoma Rhei powder and be broken into coarse powder, add alcohol reflux, extracting solution is concentrated into clear paste, and is subsequent use; Get Fructus Jujubae, add decocting and boil, decoction liquor is concentrated into clear paste, and is subsequent use; With above-mentioned gained clear paste drying under reduced pressure, get dry extract, dried cream powder is broken into fine powder and Semen Crotonis Pulveratum, the Moschus mixing that sieves, sieve, active component is subsequent use;
C. taking polyethylene glycol is an amount of, and heating makes fusion, adds above-mentioned active component, and mixing splashes in the condensed fluid, processes drop pill, promptly gets.
Embodiment 2:
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 600g, Lignum Aquilariae Resinatum 600g, Fructus Aurantii 600g, Lignum Santali Albi 360g, Radix Et Rhizoma Rhei 360g, Cortex Magnoliae Officinalis 600g, Moschus 18g, Semen Crotonis Pulveratum 240g, Fructus Jujubae 2000g, Rhizoma Chuanxiong 360g are subsequent use;
B. get the Radix Aucklandiae, Lignum Aquilariae Resinatum, Lignum Santali Albi, Fructus Aurantii, Cortex Magnoliae Officinalis, Rhizoma Chuanxiong, Radix Et Rhizoma Rhei powder and be broken into coarse powder, add 40% alcohol reflux 2 times, each 4 times of amounts of alcohol adding amount; Refluxed 1 hour, and filtered merging filtrate; The clear paste of relative density 1.05-1.15 is subsequent use when under 40 ℃, being concentrated into 40 ℃; Get Fructus Jujubae, add decocting and boil 2 times, add 4 times of amounts of water at every turn, refluxed 1 hour, filter, merging filtrate, the clear paste of relative density 1.08-1.12 is subsequent use when under 40 ℃, being concentrated into 40 ℃; With above-mentioned gained clear paste drying under reduced pressure, get dry extract, dried cream powder is broken into fine powder and Semen Crotonis Pulveratum, the Moschus mixing that sieves, sieve, active component is subsequent use;
C. above-mentioned active component is processed drop pill.
Embodiment 3:
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 200g, Lignum Aquilariae Resinatum 150g, Fructus Aurantii 600g, Lignum Santali Albi 360g, Radix Et Rhizoma Rhei 90g, Cortex Magnoliae Officinalis 200g, Moschus 10g, Semen Crotonis Pulveratum 80g, Fructus Jujubae 1500g, Rhizoma Chuanxiong 300g are subsequent use;
B. get the Radix Aucklandiae, Lignum Aquilariae Resinatum, Lignum Santali Albi, Fructus Aurantii, Cortex Magnoliae Officinalis, Rhizoma Chuanxiong, Radix Et Rhizoma Rhei powder and be broken into coarse powder, add 90% alcohol reflux 3 times, each 12 times of amounts of alcohol adding amount; Refluxed 4 hours, and filtered merging filtrate; The clear paste of relative density 1.15-1.45 is subsequent use when under 85 ℃, being concentrated into 80 ℃; Get Fructus Jujubae, add decocting and boil 3 times, add 12 times of amounts of water at every turn, refluxed 4 hours, filter, merging filtrate, the clear paste of relative density 1.18-1.42 is subsequent use when under 95 ℃, being concentrated into 80 ℃; With above-mentioned gained clear paste drying under reduced pressure, get dry extract, dried cream powder is broken into fine powder and Semen Crotonis Pulveratum, the Moschus mixing that sieves, sieve, active component is subsequent use;
C. above-mentioned active component is mixed with additive of tablet, process tablet
Embodiment 4:
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 250g, Lignum Aquilariae Resinatum 250g, Fructus Aurantii 250g, Lignum Santali Albi 150g, Radix Et Rhizoma Rhei 250g, Cortex Magnoliae Officinalis 250g, artificial Moschus 6g, Semen Crotonis Pulveratum 100g, Fructus Jujubae 800g, Rhizoma Chuanxiong 150g are subsequent use;
B. get the Radix Aucklandiae, Lignum Aquilariae Resinatum, Lignum Santali Albi, Fructus Aurantii, Cortex Magnoliae Officinalis, Rhizoma Chuanxiong, Radix Et Rhizoma Rhei powder and be broken into coarse powder, add 50% alcohol reflux 2 times, each 6 times of amounts of alcohol adding amount; Refluxed 2 hours, and filtered merging filtrate; The clear paste of relative density 1.10-1.25 is subsequent use when under 50 ℃, being concentrated into 50 ℃; Get Fructus Jujubae, add decocting and boil 2 times, add 5 times of amounts of water at every turn, refluxed 1 hour, filter, merging filtrate, the clear paste of relative density 1.18-1.30 is subsequent use when under 60 ℃, being concentrated into 50 ℃; With above-mentioned gained clear paste drying under reduced pressure, get dry extract, dried cream powder is broken into fine powder and Semen Crotonis Pulveratum, the Moschus mixing that sieves, sieve, active component is subsequent use;
C. above-mentioned active component is processed granule.
Embodiment 5:
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 400g, Lignum Aquilariae Resinatum 400g, Fructus Aurantii 400g, Lignum Santali Albi 250g, Radix Et Rhizoma Rhei 250g, Cortex Magnoliae Officinalis 400g, artificial Moschus 12g, Semen Crotonis Pulveratum 150g, Fructus Jujubae 1200g, Rhizoma Chuanxiong 250g are subsequent use;
B. get the Radix Aucklandiae, Lignum Aquilariae Resinatum, Lignum Santali Albi, Fructus Aurantii, Cortex Magnoliae Officinalis, Rhizoma Chuanxiong, Radix Et Rhizoma Rhei powder and be broken into coarse powder, add 70% alcohol reflux 2 times, each 8 times of amounts of alcohol adding amount; Refluxed 2.5 hours, and filtered merging filtrate; The clear paste of relative density 1.25-1.35 is subsequent use when under 75 ℃, being concentrated into 60 ℃; Get Fructus Jujubae, add decocting and boil 2 times, add 8 times of amounts of water at every turn, refluxed 3 hours, filter, merging filtrate, the clear paste of relative density 1.28-1.32 is subsequent use when under 85 ℃, being concentrated into 65 ℃; With above-mentioned gained clear paste drying under reduced pressure, get dry extract, dried cream powder is broken into fine powder and Semen Crotonis Pulveratum, the Moschus mixing that sieves, sieve, active component is subsequent use;
C. above-mentioned active component is processed capsule.
Embodiment 6
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 300g, Lignum Aquilariae Resinatum 300g, Fructus Aurantii (parched with bran) 300g, Lignum Santali Albi 180g, Radix Et Rhizoma Rhei 180g, Cortex Magnoliae Officinalis (Rhizoma Zingiberis Recens is processed) 300g, artificial Moschus 9g, Semen Crotonis Pulveratum 120g, Fructus Jujubae (enucleation) 1000g, Rhizoma Chuanxiong 180g are subsequent use;
B. get the Radix Aucklandiae, Lignum Aquilariae Resinatum, Lignum Santali Albi, Fructus Aurantii, Cortex Magnoliae Officinalis, Rhizoma Chuanxiong, Radix Et Rhizoma Rhei powder and be broken into coarse powder, add 80% alcohol reflux 2 times, 8 times of amounts of alcohol adding amount refluxed 2 hours for the first time; 6 times of amounts of alcohol adding amount refluxed 1 hour for the second time, filtered, and merged secondary filtrating, and the clear paste of relative density 1.25-1.30 is subsequent use when under 60-65 ℃, being concentrated into 60 ℃; Get Fructus Jujubae, add decocting and boil 2 times, add 10 times of amounts of water for the first time, refluxed 2 hours; For the second time add 8 times of amounts of water, refluxed 1 hour, filter, merge filtrating 2 times, the clear paste of relative density 1.28-1.32 is subsequent use when under 80-85 ℃, being concentrated into 60 ℃; With above-mentioned gained clear paste drying under reduced pressure, get dry extract, dried cream powder is broken into fine powder and Semen Crotonis Pulveratum, the Moschus mixing that sieves, and crosses 80 mesh sieves, active component is subsequent use;
C. above-mentioned active component is processed 1000 tablets.
Embodiment 7
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 250g, Lignum Aquilariae Resinatum 300g, Fructus Aurantii (parched with bran) 250g, Lignum Santali Albi 180g, Radix Et Rhizoma Rhei 180g, Cortex Magnoliae Officinalis (Rhizoma Zingiberis Recens is processed) 300g, artificial Moschus 9g, Semen Crotonis Pulveratum 120g, Fructus Jujubae (enucleation) 1200g, Rhizoma Chuanxiong 180g are subsequent use;
B. get the Radix Aucklandiae, Lignum Aquilariae Resinatum, Lignum Santali Albi, Fructus Aurantii, Cortex Magnoliae Officinalis, Rhizoma Chuanxiong, Radix Et Rhizoma Rhei powder and be broken into coarse powder, add 80% alcohol reflux 2 times, 12 times of amounts of alcohol adding amount refluxed 2.5 hours for the first time; 6 times of amounts of alcohol adding amount refluxed 1.5 hours for the second time, filtered, and merged secondary filtrating, and the clear paste of relative density 1.25-1.30 is subsequent use when under 60-65 ℃, being concentrated into 50 ℃; Get Fructus Jujubae, add decocting and boil 2 times, add 12 times of amounts of water for the first time, refluxed 2.5 hours; For the second time add 6 times of amounts of water, refluxed 1 hour, filter, merge filtrating 2 times, the clear paste of relative density 1.28-1.32 is subsequent use when under 80-85 ℃, being concentrated into 70 ℃; With above-mentioned gained clear paste drying under reduced pressure, get dry extract, dried cream powder is broken into fine powder and Semen Crotonis Pulveratum, the Moschus mixing that sieves, and crosses 60 mesh sieves, active component is subsequent use;
C. above-mentioned active component is processed soft capsule.
Embodiment 8
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 400g, Lignum Aquilariae Resinatum 250g, Fructus Aurantii 400g, Lignum Santali Albi 150g, Radix Et Rhizoma Rhei 250g, Cortex Magnoliae Officinalis 250g, artificial Moschus 10g, Semen Crotonis Pulveratum 100g, Fructus Jujubae 1200g, Rhizoma Chuanxiong 150g are subsequent use;
B. get the Radix Aucklandiae, Lignum Aquilariae Resinatum, Lignum Santali Albi, Fructus Aurantii, Cortex Magnoliae Officinalis, Rhizoma Chuanxiong, Radix Et Rhizoma Rhei powder and be broken into coarse powder, add 70% alcohol reflux 2 times, 9 times of amounts of alcohol adding amount refluxed 2 hours for the first time; 5 times of amounts of alcohol adding amount refluxed 0.5 hour for the second time, filtered, and merged secondary filtrating, and the clear paste of relative density 1.25-1.30 is subsequent use when under 60-65 ℃, being concentrated into 60 ℃; Get Fructus Jujubae, add decocting and boil 2 times, add 12 times of amounts of water for the first time, refluxed 2 hours; For the second time add 6 times of amounts of water, refluxed 1.5 hours, filter, merge filtrating 2 times, the clear paste of relative density 1.28-1.32 is subsequent use when under 80-85 ℃, being concentrated into 60 ℃; With above-mentioned gained clear paste drying under reduced pressure, get dry extract, dried cream powder is broken into fine powder and Semen Crotonis Pulveratum, the Moschus mixing that sieves, sieve, active component is subsequent use;
C. above-mentioned active component is processed pill.
Embodiment 9
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 280g, Lignum Aquilariae Resinatum 320g, Fructus Aurantii 360g, Lignum Santali Albi 180g, Radix Et Rhizoma Rhei 200g, Cortex Magnoliae Officinalis 400g, Moschus 8g, Semen Crotonis Pulveratum 120g, Fructus Jujubae 900g, Rhizoma Chuanxiong 180g are subsequent use;
B. get the Radix Aucklandiae, Lignum Aquilariae Resinatum, Lignum Santali Albi, Fructus Aurantii, Cortex Magnoliae Officinalis, Rhizoma Chuanxiong, Radix Et Rhizoma Rhei powder and be broken into coarse powder, add 85% alcohol reflux 2 times, 6 times of amounts of alcohol adding amount refluxed 1 hour for the first time; 4 times of amounts of alcohol adding amount refluxed 1.5 hours for the second time, filtered, and merged secondary filtrating, and the clear paste of relative density 1.20-1.30 is subsequent use when under 70-75 ℃, being concentrated into 70 ℃; Get Fructus Jujubae, add decocting and boil 2 times, add 12 times of amounts of water for the first time, refluxed 1 hour; For the second time add 6 times of amounts of water, refluxed 1.5 hours, filter, merge filtrating 2 times, the clear paste of relative density 1.28-1.32 is subsequent use when under 80-85 ℃, being concentrated into 60 ℃; With above-mentioned gained clear paste drying under reduced pressure, get dry extract, dried cream powder is broken into fine powder and Semen Crotonis Pulveratum, the Moschus mixing that sieves, sieve, active component is subsequent use;
C. above-mentioned active component is processed granule.
Embodiment 10
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 300g, Lignum Aquilariae Resinatum 350g, Fructus Aurantii (parched with bran) 350g, Lignum Santali Albi 200g, Radix Et Rhizoma Rhei 200g, Cortex Magnoliae Officinalis (Rhizoma Zingiberis Recens is processed) 300g, Moschus 7g, Semen Crotonis Pulveratum 120g, Fructus Jujubae (enucleation) 1000g, Rhizoma Chuanxiong 200g are subsequent use;
B. get the Radix Aucklandiae, Lignum Aquilariae Resinatum, Lignum Santali Albi, Fructus Aurantii, Cortex Magnoliae Officinalis, Rhizoma Chuanxiong, Radix Et Rhizoma Rhei powder and be broken into coarse powder, add 80% alcohol reflux 2 times, 6 times of amounts of alcohol adding amount refluxed 1 hour for the first time; 8 times of amounts of alcohol adding amount refluxed 2 hours for the second time, filtered, and merged secondary filtrating, and the clear paste of relative density 1.20-125 is subsequent use when under 60-65 ℃, being concentrated into 40 ℃; Get Fructus Jujubae, add decocting and boil 2 times, add 8 times of amounts of water for the first time, refluxed 1 hour; For the second time add 10 times of amounts of water, refluxed 2 hours, filter, merge filtrating 2 times, the clear paste of relative density 1.18-1.22 is subsequent use when under 70-75 ℃, being concentrated into 60 ℃; With above-mentioned gained clear paste drying under reduced pressure, get dry extract, dried cream powder is broken into fine powder and Semen Crotonis Pulveratum, the Moschus mixing that sieves, and crosses 80 mesh sieves, active component is subsequent use;
C. above-mentioned active component is processed drop pill.
Embodiment 11
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 500g, Lignum Aquilariae Resinatum 300g, Fructus Aurantii 450g, Lignum Santali Albi 100g, Radix Et Rhizoma Rhei 200g, Cortex Magnoliae Officinalis 600g, Moschus 10g, Semen Crotonis Pulveratum 60g, Fructus Jujubae 800g, Rhizoma Chuanxiong 160g are subsequent use;
B. get the Radix Aucklandiae, Lignum Aquilariae Resinatum, Lignum Santali Albi, Fructus Aurantii, Cortex Magnoliae Officinalis, Rhizoma Chuanxiong, Radix Et Rhizoma Rhei powder and be broken into coarse powder, add 90% alcohol reflux 2 times, 9 times of amounts of alcohol adding amount refluxed 4 hours for the first time; 7 times of amounts of alcohol adding amount refluxed 2 hours for the second time, filtered, and merged secondary filtrating, and the clear paste of relative density 1.15-1.20 is subsequent use when under 80-85 ℃, being concentrated into 70 ℃; Get Fructus Jujubae, add decocting and boil 2 times, add 12 times of amounts of water for the first time, refluxed 4 hours; For the second time add 10 times of amounts of water, refluxed 3 hours, filter, merge filtrating 2 times, the clear paste of relative density 1.18-1.30 is subsequent use when under 80-85 ℃, being concentrated into 70 ℃; With above-mentioned gained clear paste drying under reduced pressure, get dry extract, dried cream powder is broken into fine powder and Semen Crotonis Pulveratum, the Moschus mixing that sieves, sieve, active component is subsequent use;
C. above-mentioned active component is processed tablet.
Embodiment 12
Get the active component 230g that obtains according to embodiment 6 methods, soybean oil 705g, Cera Flava 9.4g, soybean phospholipid 4.95g is subsequent use;
Soybean oil, Cera Flava and the soybean phospholipid of recipe quantity are placed dispenser, and 80 ℃ of heating make Cera Flava and soybean phospholipid dissolving, stir, and put cold, subsequent use; The active component that takes by weighing recipe quantity joins in the above-mentioned emulsion, and the limit edged stirs, and makes it even, gets sepia emulsion, does further grinding with colloid mill then, medicinal liquid is transferred in the liquid storage filling of encapsulating machine, regulates loading amount, is pressed into 10000 balls.
Embodiment 13
Get the active component 54g that obtains according to embodiment 6 methods, PEG4000 120g, PEG6000 120g, subsequent use;
PEG4000 and PEG6000 mix in the water bath with thermostatic control of putting 80 ℃, and fusing back adding property component I and the dried clathrate of volatile oil are transferred to reservoir rapidly after stirring; Under 60-90 ℃, the drip diameter of 1 mm-3 mm drips apart from 2cm-5cm; Condensate temperature 0-25 ℃; Under the condition of condensed fluid height 40cm-70cm, be that coolant drips and processes 10000 balls with the liquid paraffin, absorb the surface cool agent and promptly get.
Embodiment 14
Get the active component 200g that obtains according to embodiment 6 methods, Starch Sodium 160g, lactose 600g, microcrystalline Cellulose 40g; Process granule.
Embodiment 15
Get the active component 240g that obtains according to embodiment 6 methods, carboxymethyl starch sodium 200g, lactose 360g, microcrystalline Cellulose 198g, magnesium stearate 2g processes tablet.
Claims (5)
1. preparation of drug combination method of treating gastrointestinal disease is characterized in that step is following:
A. take off column weight amount proportioning crude drug: the Radix Aucklandiae 150～600g, Lignum Aquilariae Resinatum 150～600g, Fructus Aurantii 150～600g, Lignum Santali Albi 90～360g, Radix Et Rhizoma Rhei 90～360g, Cortex Magnoliae Officinalis 150～600g, Moschus 4.5～18g, Semen Crotonis Pulveratum 60～240g, Fructus Jujubae 500～2000g, Rhizoma Chuanxiong 90～360g are subsequent use;
B. get the Radix Aucklandiae, Lignum Aquilariae Resinatum, Lignum Santali Albi, Fructus Aurantii, Cortex Magnoliae Officinalis, Rhizoma Chuanxiong, Radix Et Rhizoma Rhei powder and be broken into coarse powder, add alcohol reflux, extracting solution is concentrated into clear paste, and is subsequent use; Get Fructus Jujubae, add decocting and boil, decoction liquor is concentrated into clear paste, and is subsequent use; With above-mentioned gained clear paste drying under reduced pressure, get dry extract, dried cream powder is broken into fine powder and Semen Crotonis Pulveratum, the Moschus mixing that sieves, sieve, active component is subsequent use;
C. above-mentioned active component is processed pharmaceutical preparation.
2. the preparation of drug combination method of the said treatment gastrointestinal disease of claim 1 is characterized in that step is following:
A. take off column weight amount proportioning crude drug: the Radix Aucklandiae 250～400g, Lignum Aquilariae Resinatum 250～400g, Fructus Aurantii 250～400g, Lignum Santali Albi 150～250g, Radix Et Rhizoma Rhei 150～250g, Cortex Magnoliae Officinalis 250～400g, Moschus 6～12g, Semen Crotonis Pulveratum 100～150g, Fructus Jujubae 800～1200g, Rhizoma Chuanxiong 150～250g are subsequent use;
B. get the Radix Aucklandiae, Lignum Aquilariae Resinatum, Lignum Santali Albi, Fructus Aurantii, Cortex Magnoliae Officinalis, Rhizoma Chuanxiong, Radix Et Rhizoma Rhei powder and be broken into coarse powder; Add 40～90% alcohol reflux 2～3 times, each 3～12 times of amounts of alcohol adding amount refluxed 0.5～4 hour; Filter; Merging filtrate, the clear paste of relative density 1.05-1.45 is subsequent use when under 40-85 ℃, being concentrated into 40～80 ℃; Get Fructus Jujubae, add decocting and boil 2～3 times, add 4～12 times of amounts of water at every turn, refluxed 0.5～4 hour, filter, merging filtrate, the clear paste of relative density 1.08-1.42 is subsequent use when under 40-95 ℃, being concentrated into 40～80 ℃; With above-mentioned gained clear paste drying under reduced pressure, get dry extract, dried cream powder is broken into fine powder and Semen Crotonis Pulveratum, the Moschus mixing that sieves, sieve, active component is subsequent use;
C. above-mentioned active component is processed pharmaceutical preparation.
3. the preparation of drug combination method of the said treatment gastrointestinal disease of claim 2 is characterized in that comprising the steps:
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 300g, Lignum Aquilariae Resinatum 300g, Fructus Aurantii 300g, Lignum Santali Albi 180g, Radix Et Rhizoma Rhei 180g, Cortex Magnoliae Officinalis 300g, Moschus 9g, Semen Crotonis Pulveratum 120g, Fructus Jujubae 1000g, Rhizoma Chuanxiong 180g are subsequent use;
B. get the Radix Aucklandiae, Lignum Aquilariae Resinatum, Lignum Santali Albi, Fructus Aurantii, Cortex Magnoliae Officinalis, Rhizoma Chuanxiong, Radix Et Rhizoma Rhei powder and be broken into coarse powder, add 80% alcohol reflux 2 times, 8 times of amounts of alcohol adding amount refluxed 2 hours for the first time; 6 times of amounts of alcohol adding amount refluxed 1 hour for the second time, filtered, and merged secondary filtrating, and the clear paste of relative density 1.25-1.30 is subsequent use when under 60-65 ℃, being concentrated into 60 ℃; Get Fructus Jujubae, add decocting and boil 2 times, add 10 times of amounts of water for the first time, refluxed 2 hours; For the second time add 8 times of amounts of water, refluxed 1 hour, filter, merge filtrating 2 times, the clear paste of relative density 1.28-1.32 is subsequent use when under 80-85 ℃, being concentrated into 60 ℃; With above-mentioned gained clear paste drying under reduced pressure, get dry extract, dried cream powder is broken into fine powder and Semen Crotonis Pulveratum, the Moschus mixing that sieves, and crosses 80 mesh sieves, active component is subsequent use;
C. above-mentioned active component is processed pharmaceutical preparation.
4. the preparation of drug combination method of the arbitrary said treatment gastrointestinal disease of claim 1～3 is characterized in that, described preparation is tablet, granule, capsule, pill, drop pill, soft capsule.
5. like the preparation of drug combination method of the said treatment gastrointestinal disease of claim 1～3, it is characterized in that Fructus Aurantii is a stir-baked Fructus Aurantii in bran; Cortex Magnoliae Officinalis is a Cortex Magnoliae Officinalis (processed with ginger); Fructus Jujubae is that Fructus Jujubae, the Moschus of enucleation is the artificial Moschus.
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Address after: 300380 Yumen Road, Xiqing District, Tianjin Patentee after: Lerentang Pharmaceutical Factory of Jinyao Darentang Group Co.,Ltd. Address before: 300380 Yumen Road, Xiqing District, Tianjin Patentee before: Letrentang pharmaceutical factory of Tianjin Zhongxin Pharmaceutical Group Co.,Ltd. |
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