CN101757287B

CN101757287B - Traditional Chinese medicine composition capsule for treating gastrointestinal diseases and preparation method thereof

Info

Publication number: CN101757287B
Application number: CN2008101544214A
Authority: CN
Inventors: 陈坚; 王磊; 袁学海; 王伟; 杨瑾; 王春晨; 郝忻
Original assignee: Lerentang Pharmaceutical Factory of Tianjin Zhongxin Pharmaceutical Group Co Ltd
Current assignee: Lerentang Pharmaceutical Factory Of Jinyao Darentang Group Co ltd
Priority date: 2008-12-24
Filing date: 2008-12-24
Publication date: 2012-02-29
Anticipated expiration: 2028-12-24
Also published as: CN101757287A

Abstract

The invention relates to a traditional Chinese medicine composition capsule for treating gastrointestinal diseases and a preparation method thereof. The traditional Chinese medicine composition capsule is prepared from tens of traditional Chinese herbs of costustoot, agilawood, fructus aurantii, sanders, rheum officinale, mangnolia officinalis, muak, defatted croton seed powder, date and ligusticum wallichii. The traditional Chinese medicine composition capsule is mainly used for treating diseases of acute diarrhea, irritable bowel syndrome and the like in clinic.

Description

A kind of Chinese medicinal composition capsules of treating gastrointestinal disease and preparation method thereof

Technical field

The present invention relates to field of medicaments, particularly relate to a kind of Chinese medicinal composition capsules of treating gastrointestinal disease and preparation method thereof.

Background technology

Diarrhoea can be divided into infectious and non-infectious two types.Infectious diarrhea is divided into bacterial infection and viral infection again; Noninfectious diarrhea then can be caused by the change of improper diet, food anaphylaxis, rule of life, abrupt change of climate even multiple reason such as nervous.Motherland's medical science thinks to have loose bowels and is meant that defecation frequency increases, feces is rare clearly, even like water sample.The major lesions of having loose bowels is taste and intestine and small intestine.Its pathogenesis has being invaded by exogenous pathogen, injury due to diet, seven emotions discord, damp internal resistance and internal organs weakness etc.The clinical findings damp is caused a disease has cold-damp and damp and hot branch.The spleen and stomach function obstacle is to be caused by multiple factor, has exopathogen influence, taste weakness itself, incoordination between the liver and spleen and gastrointestinal deficiency etc. all can cause spleen and stomach function not normal and have loose bowels.Survey data shows that diarrhoea sickness rate in urban population reaches 0.4 time/people, and the rural population sickness rate reaches 0.5 time/people.Though diarrhoea is minor illness, pathogenic factor also is diversified, and changes with epoch, environment.We can say that the diarrhoea of today and the diarrhoea before 20 years see that from pathogeny the change of essence has been arranged.Along with development of times, people's living standard attains the well-off standard basically, and sanitary condition is improved greatly; Diarrhoea ratio by bacterial infection causes is fewer and feweri, on the contrary, because rhythm of life is accelerated; Struggle for existence is fierce, and the functional diarrhea ratio that pressure causes greatly obviously rises.A research shows that the diarrhoeal diseases people of China about 30% needs antibiosis usually to treat, and 70% does not need should not use antibiotic therapy yet.Consumer also more and more notices the untoward reaction of products such as berberine, norfloxacin, and the harm that abuse of antibiotics brought.Diarrhoea market is except low side antibiotic products such as berberine, norfloxacin; Some non-antibiotic products have also been introduced in recent years; Such as dioctahedral smectite, Birid Triple Viable etc.; But be positioned at high-end consumer groups, for most of consumer groups, its price positioning does not conform to the consumption location of such minor illness of suffering from diarrhoea with consumer.Analysis expert thinks, urban market diarrhoea mainly be with viral be main, be main in the rural area with bacterial infection, if according to the principle of the market segments, at present a lot of products all are difficult to cover the whole market.For alteration of intestinal flora person, available little ecological active bacteria formulation provides probiotics, improves intestinal environment, improves intestinal absorption, kinestate.As: bifidobacteria viable bacteria preparation (the happy capsule of beautiful pearl intestinal), Birid Triple Viable capsule, bacillus cicheniformis (whole intestinal rubber capsule); The intestinal mucosa protective agent: two eight body Montmorillonitums (dioctahedral smectite), the protection intestinal mucosa can suppress fixedly mycin, promotes the intestinal mucosal lesion reparation; Contain the creosote component preparation: the excessive secretion that can suppress intestinal juice.

At present on the market gastrointestinal disease treating pill is mainly used in treatment diarrhoea, enteritis, and bacillary dysentery, distension and fullness in the abdomen, stomachache, the food stagnation infantile dyspepsia, its pharmacological action is higher than like product: diarrhea, antibiotic, antiviral, four kinds of functions of adjusting gastrointestinal function are also deposited.But contain Cinnabaris in its prescription; Its effect is a tranquillizing the mind by relieving convulsion; But contain hydrargyrum in the Cinnabaris; Hydrargyrum is very big to the harm of human body, and it is the process of a subtle lasting absorption, and human body contacts hydrargyrum for a long time can cause chronic poisoning: nerve, digestion, hormonal system and kidney to the people produce harm; Neurasthenic crowd may cause symptoms such as headache, dizziness, insomnia, hypomnesis, malaise; And anemia of pregnant woman and the women of age of sucking contact hydrargyrum for a long time, also possibly endanger fetus and baby's health.Mercurous in addition medicine has received certain restriction when exporting other countries, require mercury content to require then strict more for some European countries less than 0.5ppm like Singapore.

Summary of the invention

A kind of Chinese medicinal composition capsules of treating gastrointestinal disease that provides to be solved of the present invention.

Of the present invention another to be solvedly provides a kind of method for preparing of treating the Chinese medicinal composition capsules of gastrointestinal disease.

The present invention treats in the Chinese medicinal composition capsules of gastrointestinal disease and contains the Radix Aucklandiae, Lignum Aquilariae Resinatum, Fructus Aurantii, Lignum Santali Albi, Radix Et Rhizoma Rhei, Cortex Magnoliae Officinalis, Moschus, Semen Crotonis Pulveratum, Fructus Jujubae, Rhizoma Chuanxiong crude drug.Chinese medicinal composition capsules of the present invention has been selected Lignum Aquilariae Resinatum, Lignum Santali Albi, Radix Aucklandiae removing dampness by means of aromatics, regulating QI to relieve pain, non-return, the invigorating the spleen to arrest diarrhea of sending down the abnormal ascending QI for use to the pathogeny of having loose bowels.Wherein Lignum Aquilariae Resinatum sending down the abnormal ascending QI, Lignum Santali Albi rise gas, the Radix Aucklandiae is longer than the stagnant gas of capable the intestines and stomach.Three medicine mutual reinforcements between are for using stasis, promoting the circulation of QI to relieve pain, reason spleen antidiarrheal, removing dampness by means of aromatics, the expelling cold to relieve vomiting of function of spleen and stomach regulating intestine and small intestine effectively.Be aided with Fructus Aurantii, Cortex Magnoliae Officinalis, the painful abdominal mass removing dampness that disappears of regulating the flow of vital energy is loose long-pendingly, and intestinal stasis relieving helps digestion, and is equipped with gas medicine in the Rhizoma Chuanxiong fortune blood with blood-activating and qi-promoting.The six hollow viscera must keep its unobstructed, also the disease of having loose bowels itself also is a kind of function of human body self-protection.Invade as pathogenic factor, blindness antidiarrheal was closed door and is stayed Kou Zhiyu when dyspepsia was stagnated, so we have selected for use Radix Et Rhizoma Rhei, Semen Crotonis Pulveratum with stasis removing; Radix Et Rhizoma Rhei bitter cold, Semen Crotonis Pulveratum are hot; Two medicine fit applications have promptly been avoided the too numbness of cold and heat, have strengthened stasis removing again and have removed evil malicious the stagnating of delaying at enteral.This treating incontinent symptoms (pseudomorph) by dredging method reach the purpose that toxin expelling antidiarrheal is not stayed poison from method of treatment.This also is our most important character.Be equipped with the Fructus Jujubae spleen reinforcing, relax the property of medicine.All medicines share, with reach eliminating turbid pathogen with aromatics, regulating QI to relieve pain, the effect of the intestinal stasis relieving that is good for the stomach, with the treatment turbid damp obstructing in middle-JIAO, the diarrhoea due to dyspepsia is not changed, poor appetite, feel sick, diseases such as vomiting, abdominal distention, stomachache, dyspepsia, enteritis, bacillary dysentery, viral diarrhea.

The present invention treats the Chinese medicinal composition capsules of gastrointestinal disease, can adopt following method to prepare active component for crude drug: like one or several Combined application preparations in extraction, water extraction, decoction and alcohol sedimentation technique, extraction, infusion process, percolation, reflux extraction, continuous backflow extraction method, the macroreticular resin absorbing method.But in order to make each crude drug of this medicine bring into play drug effect better, the present invention preferably adopts following technology to extract active component to raw material, and processes the Chinese medicinal composition capsules that the present invention treats gastrointestinal disease, but this can not limit protection scope of the present invention.

The present invention treats the Chinese medicinal composition capsules of gastrointestinal disease, and employing is prepared as follows method and processes:

A. take off column weight amount proportioning crude drug: the Radix Aucklandiae 150～600g, Lignum Aquilariae Resinatum 150～600g, Fructus Aurantii 150～600g, Lignum Santali Albi 90～360g, Radix Et Rhizoma Rhei 90～360g, Cortex Magnoliae Officinalis 150～600g, Moschus 4.5～18g, Semen Crotonis Pulveratum 60～240g, Fructus Jujubae 500～2000g, Rhizoma Chuanxiong 90～360g are subsequent use;

B. above ten flavors, Semen Crotonis Pulveratum, Moschus pulverize separately become fine powder; The Radix Aucklandiae, Lignum Aquilariae Resinatum, Fructus Aurantii, Lignum Santali Albi, Radix Et Rhizoma Rhei, Cortex Magnoliae Officinalis, Fructus Jujubae, Rhizoma Chuanxiong eight flavors are ground into fine powder; With Semen Crotonis Pulveratum, Moschus powder facing-up, mixing sieves, and it is subsequent use to get the hybrid medicine powder;

Perhaps above ten flavor medicines, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is subsequent use; The Radix Aucklandiae, Lignum Aquilariae Resinatum, Lignum Santali Albi, Fructus Aurantii Immaturus, Cortex Magnoliae Officinalis, Rhizoma Chuanxiong, Rhizoma Coptidis or Radix Scutellariae are pulverized, CO ₂Supercritical extraction; Get extract, add an amount of anhydrous alcohol solution, carry out enclose with an amount of β-CD, drying promptly gets clathrate, and is subsequent use; With the medicinal residues ethanol extraction secondary behind the above-mentioned supercritical extraction, merge secondary filtrating, reclaim ethanol and concentrate subsequent use; Get Fructus Jujubae decocte with water secondary, filter; Merging filtrate concentrates, and with above-mentioned alcohol extract condensed cream mixing, drying is ground into fine powder, with clathrate, Semen Crotonis Pulveratum, Moschus mixing, sieves again, and it is subsequent use to get the hybrid medicine powder;

Perhaps above ten flavor medicines, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is subsequent use; Six-element medicated powder such as Lignum Aquilariae Resinatum, the Radix Aucklandiae, Lignum Santali Albi, Fructus Aurantii Immaturus, Cortex Magnoliae Officinalis, Rhizoma Chuanxiong are broken into coarse powder, add water, soak, and decocting boils distillation, collect volatile oil, and are after β-CD inclusion, subsequent use; Decocting liquid filters, and filtrating concentrates subsequent use, and medicinal residues and Rhizoma Coptidis or Radix Scutellariae coarse powder add alcohol reflux 2 times, filters; Merge secondary filtrating, concentrate, drying, subsequent use; Get Fructus Jujubae, add decocting and boil secondary, filter; Merge secondary filtrating, concentrate, drying, the above-mentioned fine powder that is dried and crushed into, with bag and thing, Semen Crotonis Pulveratum, Moschus mixing, must the hybrid medicine powder subsequent use;

Perhaps get the Radix Aucklandiae, Lignum Aquilariae Resinatum, Lignum Santali Albi, Fructus Aurantii, Cortex Magnoliae Officinalis, Rhizoma Chuanxiong, Radix Et Rhizoma Rhei powder and be broken into coarse powder, add alcohol reflux, filter; Merging filtrate, subsequent use; The concentrating under reduced pressure alcohol extract concentrates subsequent use; Get Fructus Jujubae, add decocting and boil, filter, concentrating under reduced pressure Fructus Jujubae water extract, the simmer down to clear paste, subsequent use; With above-mentioned gained clear paste drying under reduced pressure, getting dry extract is ground into fine powder and Semen Crotonis Pulveratum, Moschus mixing, sieve, the hybrid medicine powder is subsequent use;

Perhaps above ten flavors, Semen Crotonis Pulveratum, Moschus pulverize separately become fine powder; All the other eight flavor medicine decocte with water 1～3 time, each 1～3 hour, collecting decoction filtered, and is condensed into thick paste; In above-mentioned thick paste, add Semen Crotonis Pulveratum, Moschus powder, mixing, it is subsequent use to get the hybrid medicine powder;

Perhaps above ten flavors, Semen Crotonis Pulveratum, Moschus pulverize separately become fine powder; It is subsequent use that the Radix Aucklandiae, Lignum Aquilariae Resinatum, Lignum Santali Albi extract volatile oil, and extracting solution filters, with five kinds of Chinese medicine decocte with water such as all the other Rhizoma Chuanxiongs, Fructus Aurantii, Cortex Magnoliae Officinalis, Fructus Jujubae, Radix Et Rhizoma Rhei 2～4 times; Each 1～4 hour, collecting decoction filtered; Concentrate, drying is ground into fine powder; With Semen Crotonis Pulveratum, Moschus powder facing-up, mixing, it is subsequent use to get mix powder;

C. in above-mentioned arbitrary mixture, add the appropriate amount of starch mixing, sieve, process granule, add volatile oil such as the Radix Aucklandiae again, mixing, drying, encapsulated, promptly get;

Perhaps add an amount of vegetable oil to above-mentioned arbitrary mixture, add volatile oil such as the Radix Aucklandiae again, mixing is processed soft capsule, promptly gets.

The present invention preferably treats the Chinese medicinal composition capsules of gastrointestinal disease, and employing is prepared as follows method and processes:

A. take off column weight amount proportioning crude drug: the Radix Aucklandiae 250～400g, Lignum Aquilariae Resinatum 250～400g, Fructus Aurantii 250～400g, Lignum Santali Albi 150～250g, Radix Et Rhizoma Rhei 150～250g, Cortex Magnoliae Officinalis 250～400g, Moschus 6～12g, Semen Crotonis Pulveratum 100～150g, Fructus Jujubae 800～1200g, Rhizoma Chuanxiong 150～250g and subsequent use;

Perhaps above ten flavor medicines, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is subsequent use; Lignum Aquilariae Resinatum, the Radix Aucklandiae, Lignum Santali Albi, Fructus Aurantii Immaturus, Cortex Magnoliae Officinalis, Rhizoma Chuanxiong, Rhizoma Coptidis or Radix Scutellariae powder are broken into 40-80 purpose powder, CO ₂Supercritical extraction, extracting pressure 5-40MPa, temperature 35-60 ℃, CO ₂Flow velocity 20-35L/h, extraction 2-5h; Get extract, add an amount of anhydrous alcohol solution,, adopt polishing to carry out enclose,, promptly get clathrate in 40 ℃ of vacuum dryings with an amount of β-CD, subsequent use; Medicinal residues behind the above-mentioned supercritical extraction are added 60% ethanol extraction secondary, merge secondary filtrating, relative density is that 1.25-1.30 is subsequent use when reclaiming ethanol to 60 ℃; Get Fructus Jujubae decocte with water secondary, each 2h filters; Merging filtrate, relative density 1.25-1.30 when being concentrated into 60 ℃, with above-mentioned alcohol extract condensed cream mixing, drying is ground into fine powder, again with clathrate, Semen Crotonis Pulveratum, Moschus mixing, crosses 80 mesh sieves, and it is subsequent use to get the hybrid medicine powder;

Perhaps above ten flavor medicines, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is subsequent use; Six-element medicated powder such as Lignum Aquilariae Resinatum, the Radix Aucklandiae, Lignum Santali Albi, Fructus Aurantii Immaturus, Cortex Magnoliae Officinalis, Rhizoma Chuanxiong are broken into coarse powder, add 16 times of water gagings, soak 4 hours, and decocting boils distillation 8h altogether, collects volatile oil, and is after β-CD inclusion, subsequent use; Decocting liquid filters, and relative density 1.25-1.30 was subsequent use when filtrating was concentrated into 60 ℃, and medicinal residues and Rhizoma Coptidis or Radix Scutellariae coarse powder add 70% alcohol reflux 2 times, for the first time 2h; 1h filters for the second time; Merge secondary filtrating, relative density 1.20-1.25 when being concentrated into 60 ℃, drying, subsequent use; Get Fructus Jujubae, add decocting and boil secondary, each 2h filters; Merge secondary filtrating, relative density 1.28-1.32 when being concentrated into 60 ℃, drying, with the above-mentioned fine powder that is dried and crushed into,, must the hybrid medicine powder subsequent use with bag and thing, Semen Crotonis Pulveratum, Moschus mixing;

Perhaps get the Radix Aucklandiae, Lignum Aquilariae Resinatum, Lignum Santali Albi, Fructus Aurantii, Cortex Magnoliae Officinalis, Rhizoma Chuanxiong, Radix Et Rhizoma Rhei powder and be broken into coarse powder, add 80% alcohol reflux 2 times, 8 times of amounts of alcohol adding amount for the first time, backflow 2h; 6 times of amounts of the alcohol adding amount second time, backflow 1h filters; Merge secondary filtrating, subsequent use; Relative density 1.25-1.30 is subsequent use when concentrating under reduced pressure alcohol extract, 60 ℃ of 60-65 ℃ of simmer down tos; Get Fructus Jujubae, add decocting and boil secondary, add 10 times of amounts of water, backflow 2h for the first time; For the second time add 8 times of amounts of water, backflow 1h filters, and merges secondary filtrating, and is subsequent use; Concentrating under reduced pressure Fructus Jujubae water extract, the clear paste of relative density 1.28-1.32 is subsequent use when 60 ℃ of 80-85 ℃ of following simmer down tos; With above-mentioned gained clear paste drying under reduced pressure, getting dry extract is ground into fine powder and Semen Crotonis Pulveratum, Moschus mixing, crosses 80 mesh sieves, the hybrid medicine powder is subsequent use;

Perhaps above ten flavors, Semen Crotonis Pulveratum, Moschus pulverize separately become fine powder; Eight flavor medicine decocte with water such as all the other Radix Aucklandiae, Lignum Aquilariae Resinatum 2 times, each 2 hours, collecting decoction filtered, and is condensed into thick paste, in above-mentioned thick paste, adds Semen Crotonis Pulveratum, Moschus powder, mixing, it is subsequent use to get the hybrid medicine powder;

The Chinese medicinal composition capsules of the further preferred treatment gastrointestinal disease of the present invention, employing is prepared as follows method and processes:

A. take off column weight amount proportioning crude drug: Radix Aucklandiae 300g, Lignum Aquilariae Resinatum 300g, Fructus Aurantii 300g, Lignum Santali Albi 180g, Radix Et Rhizoma Rhei 180g, Cortex Magnoliae Officinalis 300g, Moschus 9g, Semen Crotonis Pulveratum 120g, Fructus Jujubae 1000g, Rhizoma Chuanxiong 180g are subsequent use;

Perhaps above ten flavors, Semen Crotonis Pulveratum, Moschus pulverize separately become fine powder; It is subsequent use that the Radix Aucklandiae, Lignum Aquilariae Resinatum, Lignum Santali Albi extract volatile oil, and extracting solution filters, with five kinds of Chinese medicine decocte with water such as all the other Rhizoma Chuanxiongs, Fructus Aurantii, Cortex Magnoliae Officinalis, Fructus Jujubae, Radix Et Rhizoma Rhei 2 times; Each 2 hours, collecting decoction filtered; Concentrate, drying is ground into fine powder; With Semen Crotonis Pulveratum, Moschus powder facing-up, mixing, it is subsequent use to get mix powder;

The present invention treats in the Chinese medicinal composition capsules of gastrointestinal disease, and the Fructus Aurantii among the step a is a stir-baked Fructus Aurantii in bran; Cortex Magnoliae Officinalis is a Cortex Magnoliae Officinalis (processed with ginger); Fructus Jujubae is that Fructus Jujubae, the Moschus of enucleation is the artificial Moschus.

The present invention treats in the Chinese medicinal composition capsules of gastrointestinal disease, directly pulverizes to process except that crude drug and does not contain in the capsule the Cinnabaris, can also contain Cinnabaris 75～300g in the compositions of prepared by other.

The present invention preferably treats in the Chinese medicinal composition capsules of gastrointestinal disease, directly pulverizes to process except that crude drug and does not contain in the capsule the Cinnabaris, can also contain Cinnabaris 150g in the compositions of prepared by other.

The present invention preferably treats in the Chinese medicinal composition capsules of gastrointestinal disease, gets an amount of adding distil water stirring and dissolving of β-CD, and temperature is controlled at 60 ℃; Make into saturated solution, put on the constant temperature blender with magnetic force, slowly drip and be made into 50% volatile oil solution with dehydrated alcohol in advance; Constant temperature stirs 4h, is cooled to room temperature, puts into refrigerator cold-storage 24h; Sucking filtration, 40 ℃ of vacuum drying 5h of clathrate must do clathrate.

The present invention treats the method for preparing of the Chinese medicinal composition capsules of gastrointestinal disease, and step is following:

The present invention preferably treats the method for preparing of the Chinese medicinal composition capsules of gastrointestinal disease, and step is following:

The method for preparing of the Chinese medicinal composition capsules of the further preferred treatment gastrointestinal disease of the present invention, step is following:

The present invention treats the application of Chinese medicinal composition capsules in preparation treatment irritable bowel syndrome medicine of gastrointestinal disease; And/or the Chinese medicinal composition capsules that the present invention treats gastrointestinal disease at preparation treatment diarrhoea, poor appetite, feel sick, the application in the vomiting, abdominal distention, stomachache, dyspepsia, dysentery, enteritis, functional gastrointestinal disease medicine.

More than form when producing and to increase or to reduce according to corresponding ratio; Like large-scale production can be unit with kilogram or with the ton; Small-scale production can be unit with the gram also, and weight can increase or reduce, but the crude drug material weight proportion constant rate between each composition.

The Chinese medicinal composition capsules that the present invention treats gastrointestinal disease has following advantage: convenient drug administration, and rapid-action, bioavailability is high, and side effect is little, is beneficial to for a long time to take; Technology is simple, is easy to control, constant product quality, no hazard residue; Be of value to and cover bad smell, swallow easily; Transport easy to carry.

In order to understand the present invention better, observe through the clinical use of pharmaceutical composition of the present invention below and sum up the beneficial effect of further setting forth medicine of the present invention.Below used medicine of the present invention prepares according to embodiment 6 methods in the test.

One, square medicine is formed

Pharmaceutical composition of the present invention is made up of Radix Aucklandiae 300g, Lignum Aquilariae Resinatum 300g, Fructus Aurantii (parched with bran) 300g, Lignum Santali Albi 180g, Radix Et Rhizoma Rhei 180g, Cortex Magnoliae Officinalis (Rhizoma Zingiberis Recens is processed) 300g, Moschus 9g, Semen Crotonis Pulveratum 120g, Fructus Jujubae (enucleation) 1000g, Rhizoma Chuanxiong 180g.Full side has eliminating turbid pathogen with aromatics, regulating QI to relieve pain, the merit of the intestinal stasis relieving that is good for the stomach.Medicine of the present invention is a capsule preparations, adult usage and dosage be 4/inferior, 3 times/day, be 4 weeks the course of treatment.Children's takes the circumstances into consideration decrement and takes or follow the doctor's advice.

Two, physical data

Medicine composite for curing diarrheal of the present invention diagnostic criteria is the clinical guidance principle of issuing with reference to Ministry of Public Health, by units such as Tianjin Children's hospital, Affiliated Hospital of Medical University Of Tianjin, Affiliated Hospital of Tianjin University Of Traditional Chinese Medicine, makes through consultation jointly.This group case has rotavirus enteritis patient 124 examples, lienteric diarrhea 16 examples, enteritis 114 examples, bacillary dysentery 61 examples, constipation patient 9 examples.Age reckling 1 month, maximum 65 years old.The shortest person of the course of disease 1 day, the longest individual 21 months.

Three, efficacy analysis

1, the curative effect border is accurate

Recovery from illness: medication 3～7 days, clinical symptom disappearance, stool is cultivated the positive and transfers feminine gender to.

Produce effects: medication 3 days, clinical condition volt, stool character are clearly better, and number of times reduces to below 5 times/day.

Take a turn for the better: medication 3 days, clinical symptoms, ambassador's character and number of times take a turn for the better to some extent, but do not reach the produce effects standard.

Invalid: medication sky, stool character, clinical symptoms no change.

2, treatment effect

After treatment, obtain recovery from illness 268 examples (82.7%) in 324 examples, above 16 examples (4.9%) of produce effects, 11 examples that take a turn for the better (3.4%), invalid 29 examples (9.0%), total effective rate 91%.Analysis can know that pharmaceutical composition of the present invention has better curative effect to all kinds of diarrhoea, enteritis, constipation, and it is normal that medicine of the present invention can be regulated restoration of gastrointestinal function, has dual regulation, can be used for treatment diarrhoea or constipation.

The specific embodiment

Below further set forth the method for preparing of medicine of the present invention through embodiment.

Embodiment 1

A. take off column weight amount proportioning crude drug: Radix Aucklandiae 150g, Lignum Aquilariae Resinatum 150g, Fructus Aurantii 150g, Lignum Santali Albi 90g, Radix Et Rhizoma Rhei 90g, Cortex Magnoliae Officinalis 150g, artificial Moschus 4.5g, Semen Crotonis Pulveratum 60g, Fructus Jujubae 500g, Rhizoma Chuanxiong 90g are subsequent use;

B. above ten flavors, Semen Crotonis Pulveratum, Moschus pulverize separately become fine powder; It is subsequent use that the Radix Aucklandiae, Lignum Aquilariae Resinatum, Lignum Santali Albi extract volatile oil, and extracting solution filters, with five kinds of Chinese medicine decocte with water such as all the other Rhizoma Chuanxiongs, Fructus Aurantii, Cortex Magnoliae Officinalis, Fructus Jujubae, Radix Et Rhizoma Rhei 2 times, each 4 hours, collecting decoction; Filter, concentrate, drying is ground into fine powder, with Semen Crotonis Pulveratum, Moschus powder facing-up; Mixing adds the starch mixing, sieves, and processes granule, adds volatile oil such as the Radix Aucklandiae again; Mixing, drying, encapsulated, promptly get.

Embodiment 2

A. take off column weight amount proportioning crude drug: Radix Aucklandiae 600g, Lignum Aquilariae Resinatum 600g, Fructus Aurantii 600g, Lignum Santali Albi 360g, Radix Et Rhizoma Rhei 360g, Cortex Magnoliae Officinalis 600g, Moschus 18g, Semen Crotonis Pulveratum 240g, Fructus Jujubae 2000g, Rhizoma Chuanxiong 360g, Cinnabaris 300g are subsequent use;

B. above ten flavors, Semen Crotonis Pulveratum, Moschus pulverize separately become fine powder; It is subsequent use that the Radix Aucklandiae, Lignum Aquilariae Resinatum, Lignum Santali Albi extract volatile oil, and extracting solution filters, with five kinds of Chinese medicine decocte with water such as all the other Rhizoma Chuanxiongs, Fructus Aurantii, Cortex Magnoliae Officinalis, Fructus Jujubae, Radix Et Rhizoma Rhei 4 times, each 1 hour, collecting decoction; Filter, concentrate, drying is ground into fine powder, with Semen Crotonis Pulveratum, Moschus, Cinnabar facing-up; Mixing adds the starch mixing, sieves, and processes granule, adds volatile oil such as the Radix Aucklandiae again; Mixing, drying, encapsulated, promptly get.

Embodiment 3:

A. take off column weight amount proportioning crude drug: Radix Aucklandiae 200g, Lignum Aquilariae Resinatum 150g, Fructus Aurantii 600g, Lignum Santali Albi 360g, Radix Et Rhizoma Rhei 90g, Cortex Magnoliae Officinalis 200g, Moschus 10g, Semen Crotonis Pulveratum 80g, Fructus Jujubae 1500g, Rhizoma Chuanxiong 300g are subsequent use;

B. above ten flavors, Semen Crotonis Pulveratum, Moschus pulverize separately become fine powder; It is subsequent use that the Radix Aucklandiae, Lignum Aquilariae Resinatum, Lignum Santali Albi extract volatile oil, and extracting solution filters, with five kinds of Chinese medicine decocte with water such as all the other Rhizoma Chuanxiongs, Fructus Aurantii, Cortex Magnoliae Officinalis, Fructus Jujubae, Radix Et Rhizoma Rhei 3 times, each 1 hour, collecting decoction; Filter, concentrate, drying is ground into fine powder, with Semen Crotonis Pulveratum, Moschus powder facing-up; Mixing adds the starch mixing, sieves, and processes granule, adds volatile oil such as the Radix Aucklandiae again; Mixing, drying, encapsulated, promptly get.

Embodiment 4

A. take off column weight amount proportioning crude drug: Radix Aucklandiae 250g, Lignum Aquilariae Resinatum 250g, Fructus Aurantii 250g, Lignum Santali Albi 150g, Radix Et Rhizoma Rhei 250g, Cortex Magnoliae Officinalis 250g, artificial Moschus 6g, Semen Crotonis Pulveratum 100g, Fructus Jujubae 800g, Rhizoma Chuanxiong 150g are subsequent use;

B. above ten flavors, Semen Crotonis Pulveratum, Moschus pulverize separately become fine powder; It is subsequent use that the Radix Aucklandiae, Lignum Aquilariae Resinatum, Lignum Santali Albi extract volatile oil, and extracting solution filters, with five kinds of Chinese medicine decocte with water such as all the other Rhizoma Chuanxiongs, Fructus Aurantii, Cortex Magnoliae Officinalis, Fructus Jujubae, Radix Et Rhizoma Rhei 2 times, each 2 hours, collecting decoction; Filter, concentrate, drying is ground into fine powder, with Semen Crotonis Pulveratum, Moschus powder facing-up; Mixing adds the starch mixing, sieves, and processes granule, adds volatile oil such as the Radix Aucklandiae again; Mixing, drying, encapsulated, promptly get.

Embodiment 5

A. take off column weight amount proportioning crude drug: Radix Aucklandiae 400g, Lignum Aquilariae Resinatum 400g, Fructus Aurantii 400g, Lignum Santali Albi 250g, Radix Et Rhizoma Rhei 250g, Cortex Magnoliae Officinalis 400g, Moschus 12g, Semen Crotonis Pulveratum 150g, Fructus Jujubae 1200g, Rhizoma Chuanxiong 250g, Cinnabaris 100g are subsequent use;

B. above ten flavors, Semen Crotonis Pulveratum, Moschus pulverize separately become fine powder; It is subsequent use that the Radix Aucklandiae, Lignum Aquilariae Resinatum, Lignum Santali Albi extract volatile oil, and extracting solution filters, with five kinds of Chinese medicine decocte with water such as all the other Rhizoma Chuanxiongs, Fructus Aurantii, Cortex Magnoliae Officinalis, Fructus Jujubae, Radix Et Rhizoma Rhei 3 times, each 3 hours, collecting decoction; Filter, concentrate, drying is ground into fine powder, with Semen Crotonis Pulveratum, Moschus, Cinnabaris 75g powder facing-up; Mixing adds the starch mixing, sieves, and processes granule, adds volatile oil such as the Radix Aucklandiae again; Mixing, drying, encapsulated, promptly get.

Embodiment 6

A. take off column weight amount proportioning crude drug: Radix Aucklandiae 300g, Lignum Aquilariae Resinatum 300g, Fructus Aurantii (parched with bran) 300g, Lignum Santali Albi 180g, Radix Et Rhizoma Rhei 180g, Cortex Magnoliae Officinalis (Rhizoma Zingiberis Recens is processed) 300g, Moschus 9g, Semen Crotonis Pulveratum 120g, Fructus Jujubae (enucleation) 1000g, Rhizoma Chuanxiong 180g are subsequent use;

B. above ten flavors, Semen Crotonis Pulveratum, Moschus pulverize separately become fine powder; It is subsequent use that the Radix Aucklandiae, Lignum Aquilariae Resinatum, Lignum Santali Albi extract volatile oil, and extracting solution filters, with five kinds of Chinese medicine decocte with water such as all the other Rhizoma Chuanxiongs, Fructus Aurantii, Cortex Magnoliae Officinalis, Fructus Jujubae, Radix Et Rhizoma Rhei 2 times, each 2 hours, collecting decoction; Filter, concentrate, drying is ground into fine powder, with Semen Crotonis Pulveratum, Moschus powder facing-up; Mixing adds the starch mixing, sieves, and processes granule, adds volatile oil such as the Radix Aucklandiae again, mixing; Drying, encapsulated, process 36000, promptly get.

Embodiment 7

A. take off column weight amount proportioning crude drug: Radix Aucklandiae 250g, Lignum Aquilariae Resinatum 300g, Fructus Aurantii (parched with bran) 250g, Lignum Santali Albi 180g, Radix Et Rhizoma Rhei 180g, Cortex Magnoliae Officinalis (Rhizoma Zingiberis Recens is processed) 300g, artificial Moschus 9g, Semen Crotonis Pulveratum 120g, Fructus Jujubae (enucleation) 1200g, Rhizoma Chuanxiong 180g, Cinnabaris 150g are subsequent use;

B. above ten flavors, Semen Crotonis Pulveratum, Moschus pulverize separately become fine powder; It is subsequent use that the Radix Aucklandiae, Lignum Aquilariae Resinatum, Lignum Santali Albi extract volatile oil, and extracting solution filters, with five kinds of Chinese medicine decocte with water such as all the other Rhizoma Chuanxiongs, Fructus Aurantii, Cortex Magnoliae Officinalis, Fructus Jujubae, Radix Et Rhizoma Rhei 2 times, each 2 hours, collecting decoction; Filter, concentrate, drying is ground into fine powder, with Semen Crotonis Pulveratum, Moschus, Cinnabar facing-up; Mixing adds the starch mixing, sieves, and processes granule, adds volatile oil such as the Radix Aucklandiae again, mixing; Drying, encapsulated, process 36000, promptly get.

Embodiment 8

A. take off column weight amount proportioning crude drug: Radix Aucklandiae 400g, Lignum Aquilariae Resinatum 250g, Fructus Aurantii 400g, Lignum Santali Albi 150g, Radix Et Rhizoma Rhei 250g, Cortex Magnoliae Officinalis 250g, Moschus 10g, Semen Crotonis Pulveratum 100g, Fructus Jujubae 1200g, Rhizoma Chuanxiong 150g are subsequent use;

B. above ten flavors, Semen Crotonis Pulveratum, Moschus pulverize separately become fine powder; It is subsequent use that the Radix Aucklandiae, Lignum Aquilariae Resinatum, Lignum Santali Albi extract volatile oil, and extracting solution filters, with five kinds of Chinese medicine decocte with water such as all the other Rhizoma Chuanxiongs, Fructus Aurantii, Cortex Magnoliae Officinalis, Fructus Jujubae, Radix Et Rhizoma Rhei 2 times, and 3 hours for the first time, 2 hours for the second time; Collecting decoction filters, and concentrates, and drying is ground into fine powder; With Semen Crotonis Pulveratum, Moschus powder facing-up, mixing, add the starch mixing, sieve, process granule, add volatile oil such as the Radix Aucklandiae again; Mixing, drying, encapsulated, promptly get.

Embodiment 9

A. take off column weight amount proportioning crude drug: Radix Aucklandiae 280g, Lignum Aquilariae Resinatum 320g, Fructus Aurantii 360g, Lignum Santali Albi 180g, Radix Et Rhizoma Rhei 200g, Cortex Magnoliae Officinalis 400g, Moschus 8g, Semen Crotonis Pulveratum 120g, Fructus Jujubae 900g, Rhizoma Chuanxiong 180g are subsequent use;

B. above ten flavors, Semen Crotonis Pulveratum, Moschus pulverize separately become fine powder; It is subsequent use that the Radix Aucklandiae, Lignum Aquilariae Resinatum, Lignum Santali Albi extract volatile oil, and extracting solution filters, with five kinds of Chinese medicine decocte with water such as all the other Rhizoma Chuanxiongs, Fructus Aurantii, Cortex Magnoliae Officinalis, Fructus Jujubae, Radix Et Rhizoma Rhei 2 times, and 4 hours for the first time, 1 hour for the second time; Collecting decoction filters, and concentrates, and drying is ground into fine powder; With Semen Crotonis Pulveratum, Moschus powder facing-up, mixing, add the starch mixing, sieve, process granule, add volatile oil such as the Radix Aucklandiae again; Mixing, drying, encapsulated, promptly get.

Embodiment 10

A. take off column weight amount proportioning crude drug: Radix Aucklandiae 300g, Lignum Aquilariae Resinatum 350g, Fructus Aurantii (parched with bran) 350g, Lignum Santali Albi 200g, Radix Et Rhizoma Rhei 200g, Cortex Magnoliae Officinalis (Rhizoma Zingiberis Recens is processed) 300g, Moschus 7g, Semen Crotonis Pulveratum 120g, Fructus Jujubae (enucleation) 1000g, Rhizoma Chuanxiong 200g are subsequent use;

B. above ten flavors, Semen Crotonis Pulveratum, Moschus pulverize separately become fine powder; It is subsequent use that the Radix Aucklandiae, Lignum Aquilariae Resinatum, Lignum Santali Albi extract volatile oil, and extracting solution filters, with five kinds of Chinese medicine decocte with water such as all the other Rhizoma Chuanxiongs, Fructus Aurantii, Cortex Magnoliae Officinalis, Fructus Jujubae, Radix Et Rhizoma Rhei 2 times, and 2 hours for the first time, 1 hour for the second time; Collecting decoction filters, and concentrates, and drying is ground into fine powder; With Semen Crotonis Pulveratum, Moschus powder facing-up, mixing, add the starch mixing, sieve, process granule, add volatile oil such as the Radix Aucklandiae again; Mixing, drying, encapsulated, promptly get.

Embodiment 11

A. take off column weight amount proportioning crude drug: Radix Aucklandiae 500g, Lignum Aquilariae Resinatum 300g, Fructus Aurantii 450g, Lignum Santali Albi 100g, Radix Et Rhizoma Rhei 200g, Cortex Magnoliae Officinalis 600g, artificial Moschus 10g, Semen Crotonis Pulveratum 60g, Fructus Jujubae 800g, Rhizoma Chuanxiong 160g are subsequent use;

B. above ten flavors, Semen Crotonis Pulveratum, Moschus pulverize separately become fine powder; It is subsequent use that the Radix Aucklandiae, Lignum Aquilariae Resinatum, Lignum Santali Albi extract volatile oil, and extracting solution filters, with five kinds of Chinese medicine decocte with water such as all the other Rhizoma Chuanxiongs, Fructus Aurantii, Cortex Magnoliae Officinalis, Fructus Jujubae, Radix Et Rhizoma Rhei 2 times, and 2 hours for the first time, 1.5 hours for the second time; Collecting decoction filters, and concentrates, and drying is ground into fine powder; With Semen Crotonis Pulveratum, Moschus powder facing-up, mixing, add the starch mixing, sieve, process granule, add volatile oil such as the Radix Aucklandiae again; Mixing, drying, encapsulated, promptly get.

Embodiment 12

A. take off column weight amount proportioning crude drug: Radix Aucklandiae 150g, Lignum Aquilariae Resinatum 150g, Fructus Aurantii 150g, Lignum Santali Albi 90g, Radix Et Rhizoma Rhei 90g, Cortex Magnoliae Officinalis 150g, Moschus 4.5g, Semen Crotonis Pulveratum 60g, Fructus Jujubae 500g, Rhizoma Chuanxiong 90g, Cinnabaris 75g are subsequent use;

B. above ten flavors, Semen Crotonis Pulveratum, Moschus pulverize separately become fine powder; It is subsequent use that the Radix Aucklandiae, Lignum Aquilariae Resinatum, Lignum Santali Albi extract volatile oil, and extracting solution filtered, with five kinds of Chinese medicine decocte with water such as all the other Rhizoma Chuanxiongs, Fructus Aurantii, Cortex Magnoliae Officinalis, Fructus Jujubae, Radix Et Rhizoma Rhei 3 times, each 1 hour; Collecting decoction filters, and concentrates drying; Be ground into fine powder, with Semen Crotonis Pulveratum, Moschus, Cinnabar facing-up, mixing, the adding vegetable oil is an amount of; Add volatile oil such as the Radix Aucklandiae again, mixing is processed soft capsule, promptly gets.

Embodiment 13

A. take off column weight amount proportioning crude drug: Radix Aucklandiae 600g, Lignum Aquilariae Resinatum 600g, Fructus Aurantii 600g, Lignum Santali Albi 360g, Radix Et Rhizoma Rhei 360g, Cortex Magnoliae Officinalis 600g, Moschus 18g, Semen Crotonis Pulveratum 240g, Fructus Jujubae 2000g, Rhizoma Chuanxiong 360g are subsequent use;

B. above ten flavors, Semen Crotonis Pulveratum, Moschus pulverize separately become fine powder; It is subsequent use that the Radix Aucklandiae, Lignum Aquilariae Resinatum, Lignum Santali Albi extract volatile oil, and extracting solution filtered, with five kinds of Chinese medicine decocte with water such as all the other Rhizoma Chuanxiongs, Fructus Aurantii, Cortex Magnoliae Officinalis, Fructus Jujubae, Radix Et Rhizoma Rhei 2 times, each 3 hours; Collecting decoction filters, and concentrates drying; Be ground into fine powder, with Semen Crotonis Pulveratum, Moschus powder facing-up, mixing, the adding vegetable oil is an amount of; Add volatile oil such as the Radix Aucklandiae again, mixing is processed soft capsule, promptly gets.

Embodiment 14

A. take off column weight amount proportioning crude drug: Radix Aucklandiae 200g, Lignum Aquilariae Resinatum 150g, Fructus Aurantii 600g, Lignum Santali Albi 360g, Radix Et Rhizoma Rhei 90g, Cortex Magnoliae Officinalis 200g, artificial Moschus 10g, Semen Crotonis Pulveratum 80g, Fructus Jujubae 1500g, Rhizoma Chuanxiong 300g are subsequent use;

B. above ten flavors, Semen Crotonis Pulveratum, Moschus pulverize separately become fine powder; It is subsequent use that the Radix Aucklandiae, Lignum Aquilariae Resinatum, Lignum Santali Albi extract volatile oil, and extracting solution filtered, with five kinds of Chinese medicine decocte with water such as all the other Rhizoma Chuanxiongs, Fructus Aurantii, Cortex Magnoliae Officinalis, Fructus Jujubae, Radix Et Rhizoma Rhei 3 times, each 3 hours; Collecting decoction filters, and concentrates drying; Be ground into fine powder, with Semen Crotonis Pulveratum, Moschus powder facing-up, mixing, the adding vegetable oil is an amount of; Add volatile oil such as the Radix Aucklandiae again, mixing is processed soft capsule, promptly gets.

Embodiment 15

A. take off column weight amount proportioning crude drug: Radix Aucklandiae 250g, Lignum Aquilariae Resinatum 250g, Fructus Aurantii 250g, Lignum Santali Albi 150g, Radix Et Rhizoma Rhei 250g, Cortex Magnoliae Officinalis 250g, Moschus 6g, Semen Crotonis Pulveratum 100g, Fructus Jujubae 800g, Rhizoma Chuanxiong 150g are subsequent use;

B. above ten flavors, Semen Crotonis Pulveratum, Moschus pulverize separately become fine powder; It is subsequent use that the Radix Aucklandiae, Lignum Aquilariae Resinatum, Lignum Santali Albi extract volatile oil, and extracting solution filtered, with five kinds of Chinese medicine decocte with water such as all the other Rhizoma Chuanxiongs, Fructus Aurantii, Cortex Magnoliae Officinalis, Fructus Jujubae, Radix Et Rhizoma Rhei 2 times, each 2 hours; Collecting decoction filters, and concentrates drying; Be ground into fine powder, with Semen Crotonis Pulveratum, Moschus powder facing-up, mixing, the adding vegetable oil is an amount of; Add volatile oil such as the Radix Aucklandiae again, mixing is processed soft capsule, promptly gets.

Embodiment 16

A. take off column weight amount proportioning crude drug: Radix Aucklandiae 400g, Lignum Aquilariae Resinatum 400g, Fructus Aurantii 400g, Lignum Santali Albi 250g, Radix Et Rhizoma Rhei 250g, Cortex Magnoliae Officinalis 400g, Moschus 12g, Semen Crotonis Pulveratum 150g, Fructus Jujubae 1200g, Rhizoma Chuanxiong 250g are subsequent use;

B. above ten flavors, Semen Crotonis Pulveratum, Moschus pulverize separately become fine powder; It is subsequent use that the Radix Aucklandiae, Lignum Aquilariae Resinatum, Lignum Santali Albi extract volatile oil, and extracting solution filters, with five kinds of Chinese medicine decocte with water such as all the other Rhizoma Chuanxiongs, Fructus Aurantii, Cortex Magnoliae Officinalis, Fructus Jujubae, Radix Et Rhizoma Rhei time, and each 2 hours; Collecting decoction filters, and concentrates drying; Be ground into fine powder, with Semen Crotonis Pulveratum, Moschus powder facing-up, mixing, the adding vegetable oil is an amount of; Add volatile oil such as the Radix Aucklandiae again, mixing is processed soft capsule, promptly gets.

Embodiment 17

A. take off column weight amount proportioning crude drug: Radix Aucklandiae 300g, Lignum Aquilariae Resinatum 300g, Fructus Aurantii (parched with bran) 300g, Lignum Santali Albi 180g, Radix Et Rhizoma Rhei 180g, Cortex Magnoliae Officinalis (Rhizoma Zingiberis Recens is processed) 300g, artificial Moschus 9g, Semen Crotonis Pulveratum 120g, Fructus Jujubae (enucleation) 1000g, Rhizoma Chuanxiong 180g are subsequent use;

B. above ten flavors, Semen Crotonis Pulveratum, Moschus pulverize separately become fine powder; It is subsequent use that the Radix Aucklandiae, Lignum Aquilariae Resinatum, Lignum Santali Albi extract volatile oil, and extracting solution filtered, with five kinds of Chinese medicine decocte with water such as all the other Rhizoma Chuanxiongs, Fructus Aurantii, Cortex Magnoliae Officinalis, Fructus Jujubae, Radix Et Rhizoma Rhei 2 times, each 2 hours; Collecting decoction filters, and concentrates drying; Be ground into fine powder, with Semen Crotonis Pulveratum, Moschus powder facing-up, mixing, the adding vegetable oil is an amount of; Add volatile oil such as the Radix Aucklandiae again, mixing is processed 36000 soft capsules, promptly gets.

Embodiment 18

A. take off column weight amount proportioning crude drug: Radix Aucklandiae 250g, Lignum Aquilariae Resinatum 300g, Fructus Aurantii (parched with bran) 250g, Lignum Santali Albi 180g, Radix Et Rhizoma Rhei 180g, Cortex Magnoliae Officinalis (Rhizoma Zingiberis Recens is processed) 300g, Moschus 9g, Semen Crotonis Pulveratum 120g, Fructus Jujubae (enucleation) 1200g, Rhizoma Chuanxiong 180g, Cinnabaris 200g are subsequent use;

B. above ten flavors, Semen Crotonis Pulveratum, Moschus pulverize separately become fine powder; It is subsequent use that the Radix Aucklandiae, Lignum Aquilariae Resinatum, Lignum Santali Albi extract volatile oil, and extracting solution filtered, with five kinds of Chinese medicine decocte with water such as all the other Rhizoma Chuanxiongs, Fructus Aurantii, Cortex Magnoliae Officinalis, Fructus Jujubae, Radix Et Rhizoma Rhei 2 times, each 1.5 hours; Collecting decoction filters, and concentrates drying; Be ground into fine powder, with Semen Crotonis Pulveratum, Moschus, Cinnabar facing-up, mixing, the adding vegetable oil is an amount of; Add volatile oil such as the Radix Aucklandiae again, mixing is processed soft capsule, promptly gets.

Embodiment 19

A. take off column weight amount proportioning crude drug: Radix Aucklandiae 400g, Lignum Aquilariae Resinatum 250g, Fructus Aurantii 400g, Lignum Santali Albi 150g, Radix Et Rhizoma Rhei 250g, Cortex Magnoliae Officinalis 250g, artificial Moschus 10g, Semen Crotonis Pulveratum 100g, Fructus Jujubae 1200g, Rhizoma Chuanxiong 150g are subsequent use;

B. above ten flavors, Semen Crotonis Pulveratum, Moschus pulverize separately become fine powder; It is subsequent use that the Radix Aucklandiae, Lignum Aquilariae Resinatum, Lignum Santali Albi extract volatile oil, and extracting solution filters, with five kinds of Chinese medicine decocte with water such as all the other Rhizoma Chuanxiongs, Fructus Aurantii, Cortex Magnoliae Officinalis, Fructus Jujubae, Radix Et Rhizoma Rhei 2 times, and 3 hours for the first time, 2 hours for the second time; Collecting decoction filters, and concentrates drying; Be ground into fine powder, with Semen Crotonis Pulveratum, Moschus powder facing-up, mixing, the adding vegetable oil is an amount of; Add volatile oil such as the Radix Aucklandiae again, mixing is processed soft capsule, promptly gets.

Embodiment 20

B. above ten flavors, Semen Crotonis Pulveratum, Moschus pulverize separately become fine powder; It is subsequent use that the Radix Aucklandiae, Lignum Aquilariae Resinatum, Lignum Santali Albi extract volatile oil, and extracting solution filters, with five kinds of Chinese medicine decocte with water such as all the other Rhizoma Chuanxiongs, Fructus Aurantii, Cortex Magnoliae Officinalis, Fructus Jujubae, Radix Et Rhizoma Rhei 3 times, and 3 hours for the first time, 2 hours for the second time; 1 hour for the third time, collecting decoction filtered, and concentrates drying; Be ground into fine powder, with Semen Crotonis Pulveratum, Moschus powder facing-up, mixing, the adding vegetable oil is an amount of; Add volatile oil such as the Radix Aucklandiae again, mixing is processed soft capsule, promptly gets.

Embodiment 21

B. above ten flavors, Semen Crotonis Pulveratum, Moschus pulverize separately become fine powder; It is subsequent use that the Radix Aucklandiae, Lignum Aquilariae Resinatum, Lignum Santali Albi extract volatile oil, and extracting solution filters, with five kinds of Chinese medicine decocte with water such as all the other Rhizoma Chuanxiongs, Fructus Aurantii, Cortex Magnoliae Officinalis, Fructus Jujubae, Radix Et Rhizoma Rhei 2 times, and 2 hours for the first time, 1 hour for the second time; Collecting decoction filters, and concentrates drying; Be ground into fine powder, with Semen Crotonis Pulveratum, Moschus powder facing-up, mixing, the adding vegetable oil is an amount of; Add volatile oil such as the Radix Aucklandiae again, mixing is processed soft capsule, promptly gets.

Embodiment 22

A. take off column weight amount proportioning crude drug: Radix Aucklandiae 500g, Lignum Aquilariae Resinatum 300g, Fructus Aurantii 450g, Lignum Santali Albi 100g, Radix Et Rhizoma Rhei 200g, Cortex Magnoliae Officinalis 600g, Moschus 10g, Semen Crotonis Pulveratum 60g, Fructus Jujubae 800g, Rhizoma Chuanxiong 160g are subsequent use;

B. above ten flavors, Semen Crotonis Pulveratum, Moschus pulverize separately become fine powder; It is subsequent use that the Radix Aucklandiae, Lignum Aquilariae Resinatum, Lignum Santali Albi extract volatile oil, and extracting solution filters, with five kinds of Chinese medicine decocte with water such as all the other Rhizoma Chuanxiongs, Fructus Aurantii, Cortex Magnoliae Officinalis, Fructus Jujubae, Radix Et Rhizoma Rhei 2 times, and 2.5 hours for the first time, 1 hour for the second time; Collecting decoction filters, and concentrates drying; Be ground into fine powder, with Semen Crotonis Pulveratum, Moschus powder facing-up, mixing, the adding vegetable oil is an amount of; Add volatile oil such as the Radix Aucklandiae again, mixing is processed soft capsule, promptly gets.

Embodiment 23

A. take off column weight amount proportioning crude drug: Radix Aucklandiae 150g, Lignum Aquilariae Resinatum 150g, Fructus Aurantii 150g, Lignum Santali Albi 90g, Radix Et Rhizoma Rhei 90g, Cortex Magnoliae Officinalis 150g, Moschus 4.5g, Semen Crotonis Pulveratum 60g, Fructus Jujubae 500g, Rhizoma Chuanxiong 90g are subsequent use;

C. in said mixture, add the appropriate amount of starch mixing, sieve, process granule, add volatile oil such as the Radix Aucklandiae again, mixing, drying, encapsulated, promptly get.

Embodiment 24

Embodiment 25

A. take off column weight amount proportioning crude drug: Radix Aucklandiae 250g, Lignum Aquilariae Resinatum 250g, Fructus Aurantii 250g, Lignum Santali Albi 150g, Radix Et Rhizoma Rhei 150g, Cortex Magnoliae Officinalis 250g, Moschus 6g, Semen Crotonis Pulveratum 100g, Fructus Jujubae 800g, Rhizoma Chuanxiong 150g and subsequent use;

Embodiment 26

A. take off column weight amount proportioning crude drug: Radix Aucklandiae 400g, Lignum Aquilariae Resinatum 400g, Fructus Aurantii 400g, Lignum Santali Albi 250g, Radix Et Rhizoma Rhei 250g, Cortex Magnoliae Officinalis 400g, Moschus 12g, Semen Crotonis Pulveratum 150g, Fructus Jujubae 1200g, Rhizoma Chuanxiong 250g and subsequent use;

B. above ten flavor medicines, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is subsequent use; Lignum Aquilariae Resinatum, the Radix Aucklandiae, Lignum Santali Albi, Fructus Aurantii Immaturus, Cortex Magnoliae Officinalis, Rhizoma Chuanxiong, Rhizoma Coptidis or Radix Scutellariae powder are broken into 80 purpose powder, CO ₂Supercritical extraction, extracting pressure 40MPa, 60 ℃ of temperature, CO ₂Flow velocity 35L/h, extraction 5h; Get extract, add an amount of anhydrous alcohol solution,, adopt polishing to carry out enclose,, promptly get clathrate in 40 ℃ of vacuum dryings with an amount of β-CD, subsequent use; Medicinal residues behind the above-mentioned supercritical extraction are added 60% ethanol extraction secondary, merge secondary filtrating, relative density is that 1.25-1.30 is subsequent use when reclaiming ethanol to 60 ℃; Get Fructus Jujubae decocte with water secondary, each 2h filters; Merging filtrate, relative density 1.25-1.30 when being concentrated into 60 ℃, with above-mentioned alcohol extract condensed cream mixing, drying is ground into fine powder, again with clathrate, Semen Crotonis Pulveratum, Moschus mixing, crosses 80 mesh sieves, and it is subsequent use to get the hybrid medicine powder;

Embodiment 27

Embodiment 28

B. above ten flavor medicines, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is subsequent use; The Radix Aucklandiae, Lignum Aquilariae Resinatum, Lignum Santali Albi, Fructus Aurantii Immaturus, Cortex Magnoliae Officinalis, Rhizoma Chuanxiong, Rhizoma Coptidis or Radix Scutellariae are pulverized, CO ₂Supercritical extraction; Get extract, add an amount of anhydrous alcohol solution, carry out enclose with an amount of β-CD, drying promptly gets clathrate, and is subsequent use; With the medicinal residues ethanol extraction secondary behind the above-mentioned supercritical extraction, merge secondary filtrating, reclaim ethanol and concentrate subsequent use; Get Fructus Jujubae decocte with water secondary, filter; Merging filtrate concentrates, and with above-mentioned alcohol extract condensed cream mixing, drying is ground into fine powder, with clathrate, Semen Crotonis Pulveratum, Moschus mixing, sieves again, and it is subsequent use to get the hybrid medicine powder;

Embodiment 29

B. above ten flavor medicines, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is subsequent use; Six-element medicated powder such as Lignum Aquilariae Resinatum, the Radix Aucklandiae, Lignum Santali Albi, Fructus Aurantii Immaturus, Cortex Magnoliae Officinalis, Rhizoma Chuanxiong are broken into coarse powder, add water, soak, and decocting boils distillation, collect volatile oil, and are after β-CD inclusion, subsequent use; Decocting liquid filters, and filtrating concentrates subsequent use, and medicinal residues and Rhizoma Coptidis or Radix Scutellariae coarse powder add alcohol reflux 2 times, filters; Merge secondary filtrating, concentrate, drying, subsequent use; Get Fructus Jujubae, add decocting and boil secondary, filter; Merge secondary filtrating, concentrate, drying, the above-mentioned fine powder that is dried and crushed into, with bag and thing, Semen Crotonis Pulveratum, Moschus mixing, must the hybrid medicine powder subsequent use;

Embodiment 30

B. get the Radix Aucklandiae, Lignum Aquilariae Resinatum, Lignum Santali Albi, Fructus Aurantii, Cortex Magnoliae Officinalis, Rhizoma Chuanxiong, Radix Et Rhizoma Rhei powder and be broken into coarse powder, add alcohol reflux, filter; Merging filtrate, subsequent use; The concentrating under reduced pressure alcohol extract concentrates subsequent use; Get Fructus Jujubae, add decocting and boil, filter, concentrating under reduced pressure Fructus Jujubae water extract, the simmer down to clear paste, subsequent use; With above-mentioned gained clear paste drying under reduced pressure, getting dry extract is ground into fine powder and Semen Crotonis Pulveratum, Moschus mixing, sieve, the hybrid medicine powder is subsequent use;

Embodiment 31

B. above ten flavors, Semen Crotonis Pulveratum, Moschus pulverize separately become fine powder; All the other eight flavor medicine decocte with water 2 times, each 1 hour, collecting decoction filtered, and is condensed into thick paste; In above-mentioned thick paste, add Semen Crotonis Pulveratum, Moschus powder, mixing, it is subsequent use to get the hybrid medicine powder;

C. in above-mentioned arbitrary mixture, add the appropriate amount of starch mixing, sieve, process granule, add volatile oil such as the Radix Aucklandiae again, mixing, drying, encapsulated, promptly get.

Embodiment 32

Embodiment 33

Embodiment 34

Embodiment 35

B. above ten flavors, Semen Crotonis Pulveratum, Moschus pulverize separately become fine powder; All the other eight flavor medicine decocte with water 3 times, each 3 hours, collecting decoction filtered, and is condensed into thick paste; In above-mentioned thick paste, add Semen Crotonis Pulveratum, Moschus powder, mixing, it is subsequent use to get the hybrid medicine powder;

Embodiment 36

B. above ten flavor medicines, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is subsequent use; Lignum Aquilariae Resinatum, the Radix Aucklandiae, Lignum Santali Albi, Fructus Aurantii Immaturus, Cortex Magnoliae Officinalis, Rhizoma Chuanxiong, Rhizoma Coptidis or Radix Scutellariae powder are broken into 40 purpose powder, CO ₂Supercritical extraction, extracting pressure 5MPa, 35 ℃ of temperature, CO ₂Flow velocity 20L/h, extraction 2h; Get extract, add an amount of anhydrous alcohol solution,, adopt polishing to carry out enclose,, promptly get clathrate in 40 ℃ of vacuum dryings with an amount of β-CD, subsequent use; Medicinal residues behind the above-mentioned supercritical extraction are added 60% ethanol extraction secondary, merge secondary filtrating, relative density is that 1.25-1.30 is subsequent use when reclaiming ethanol to 60 ℃; Get Fructus Jujubae decocte with water secondary, each 2h filters; Merging filtrate, relative density 1.25-1.30 when being concentrated into 60 ℃, with above-mentioned alcohol extract condensed cream mixing, drying is ground into fine powder, again with clathrate, Semen Crotonis Pulveratum, Moschus mixing, crosses 80 mesh sieves, and it is subsequent use to get the hybrid medicine powder;

Embodiment 37

B. above ten flavor medicines, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is subsequent use; Six-element medicated powder such as Lignum Aquilariae Resinatum, the Radix Aucklandiae, Lignum Santali Albi, Fructus Aurantii Immaturus, Cortex Magnoliae Officinalis, Rhizoma Chuanxiong are broken into coarse powder, add 16 times of water gagings, soak 4 hours, and decocting boils distillation 8h altogether, collects volatile oil, and is after β-CD inclusion, subsequent use; Decocting liquid filters, and relative density 1.25-1.30 was subsequent use when filtrating was concentrated into 60 ℃, and medicinal residues and Rhizoma Coptidis or Radix Scutellariae coarse powder add 70% alcohol reflux 2 times, for the first time 2h; 1h filters for the second time; Merge secondary filtrating, relative density 1.20-1.25 when being concentrated into 60 ℃, drying, subsequent use; Get Fructus Jujubae, add decocting and boil secondary, each 2h filters; Merge secondary filtrating, relative density 1.28-1.32 when being concentrated into 60 ℃, drying, with the above-mentioned fine powder that is dried and crushed into,, must the hybrid medicine powder subsequent use with bag and thing, Semen Crotonis Pulveratum, Moschus mixing;

Embodiment 38

B. get the Radix Aucklandiae, Lignum Aquilariae Resinatum, Lignum Santali Albi, Fructus Aurantii, Cortex Magnoliae Officinalis, Rhizoma Chuanxiong, Radix Et Rhizoma Rhei powder and be broken into coarse powder, add 80% alcohol reflux 2 times, 8 times of amounts of alcohol adding amount for the first time, backflow 2h; 6 times of amounts of the alcohol adding amount second time, backflow 1h filters; Merge secondary filtrating, subsequent use; Relative density 1.25-1.30 is subsequent use when concentrating under reduced pressure alcohol extract, 60 ℃ of 60 ℃ of simmer down tos; Get Fructus Jujubae, add decocting and boil secondary, add 10 times of amounts of water, backflow 2h for the first time; For the second time add 8 times of amounts of water, backflow 1h filters, and merges secondary filtrating, and is subsequent use; Concentrating under reduced pressure Fructus Jujubae water extract, the clear paste of relative density 1.28-1.32 is subsequent use when 60 ℃ of 80-85 ℃ of following simmer down tos; With above-mentioned gained clear paste drying under reduced pressure, getting dry extract is ground into fine powder and Semen Crotonis Pulveratum, Moschus mixing, crosses 80 mesh sieves, the hybrid medicine powder is subsequent use;

Embodiment 39

B. above ten flavors, Semen Crotonis Pulveratum, Moschus pulverize separately become fine powder; Eight flavor medicine decocte with water such as all the other Radix Aucklandiae, Lignum Aquilariae Resinatum 2 times, each 2 hours, collecting decoction filtered, and is condensed into thick paste, in above-mentioned thick paste, adds Semen Crotonis Pulveratum, Moschus powder, mixing, it is subsequent use to get the hybrid medicine powder;

Embodiment 40

Embodiment 41

B. get the Radix Aucklandiae, Lignum Aquilariae Resinatum, Lignum Santali Albi, Fructus Aurantii, Cortex Magnoliae Officinalis, Rhizoma Chuanxiong, Radix Et Rhizoma Rhei powder and be broken into coarse powder, add 80% alcohol reflux 2 times, 8 times of amounts of alcohol adding amount for the first time, backflow 2h; 6 times of amounts of the alcohol adding amount second time, backflow 1h filters; Merge secondary filtrating, subsequent use; Relative density 1.25-1.30 is subsequent use when concentrating under reduced pressure alcohol extract, 60 ℃ of 65 ℃ of simmer down tos; Get Fructus Jujubae, add decocting and boil secondary, add 10 times of amounts of water, backflow 2h for the first time; For the second time add 8 times of amounts of water, backflow 1h filters, and merges secondary filtrating, and is subsequent use; Concentrating under reduced pressure Fructus Jujubae water extract, the clear paste of relative density 1.28-1.32 is subsequent use when 60 ℃ of 85 ℃ of following simmer down tos; With above-mentioned gained clear paste drying under reduced pressure, getting dry extract is ground into fine powder and Semen Crotonis Pulveratum, Moschus mixing, crosses 80 mesh sieves, the hybrid medicine powder is subsequent use;

Embodiment 42

Embodiment 43

B. above ten flavor medicines, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is subsequent use; Lignum Aquilariae Resinatum, the Radix Aucklandiae, Lignum Santali Albi, Fructus Aurantii Immaturus, Cortex Magnoliae Officinalis, Rhizoma Chuanxiong, Rhizoma Coptidis or Radix Scutellariae powder are broken into 40-80 purpose powder, CO ₂Supercritical extraction, extracting pressure 5-40MPa, temperature 35-60 ℃, CO ₂Flow velocity 20-35L/h, extraction 2-5h; Get extract, add an amount of anhydrous alcohol solution,, adopt polishing to carry out enclose,, promptly get clathrate in 40 ℃ of vacuum dryings with an amount of β-CD, subsequent use; Medicinal residues behind the above-mentioned supercritical extraction are added 60% ethanol extraction secondary, merge secondary filtrating, relative density is that 1.25-1.30 is subsequent use when reclaiming ethanol to 60 ℃; Get Fructus Jujubae decocte with water secondary, each 2h filters; Merging filtrate, relative density 1.25-1.30 when being concentrated into 60 ℃, with above-mentioned alcohol extract condensed cream mixing, drying is ground into fine powder, again with clathrate, Semen Crotonis Pulveratum, Moschus mixing, crosses 80 mesh sieves, and it is subsequent use to get the hybrid medicine powder;

Embodiment 44

Embodiment 45

Embodiment 46

B. get the Radix Aucklandiae, Lignum Aquilariae Resinatum, Lignum Santali Albi, Fructus Aurantii, Cortex Magnoliae Officinalis, Rhizoma Chuanxiong, Radix Et Rhizoma Rhei powder and be broken into coarse powder, add 80% alcohol reflux 2 times, 8 times of amounts of alcohol adding amount for the first time, backflow 2h; 6 times of amounts of the alcohol adding amount second time, backflow 1h filters; Merge secondary filtrating, subsequent use; Relative density 1.25-1.30 is subsequent use when concentrating under reduced pressure alcohol extract, 60 ℃ of 60-65 ℃ of simmer down tos; Get Fructus Jujubae, add decocting and boil secondary, add 10 times of amounts of water, backflow 2h for the first time; For the second time add 8 times of amounts of water, backflow 1h filters, and merges secondary filtrating, and is subsequent use; Concentrating under reduced pressure Fructus Jujubae water extract, the clear paste of relative density 1.28-1.32 is subsequent use when 60 ℃ of 80-85 ℃ of following simmer down tos; With above-mentioned gained clear paste drying under reduced pressure, getting dry extract is ground into fine powder and Semen Crotonis Pulveratum, Moschus mixing, crosses 80 mesh sieves, the hybrid medicine powder is subsequent use;

Embodiment 47

C. add an amount of vegetable oil to said mixture, add volatile oil such as the Radix Aucklandiae again, mixing is processed soft capsule, promptly gets.

Embodiment 48

Embodiment 49

Embodiment 50

Embodiment 51

Embodiment 52

Embodiment 53

Embodiment 54

A. take off column weight amount proportioning crude drug: Radix Aucklandiae 150g, Lignum Aquilariae Resinatum 150g, Fructus Aurantii 150g, Lignum Santali Albi 90g, Radix Et Rhizoma Rhei 90g, Cortex Magnoliae Officinalis 150g, Moschus 4.5g, Semen Crotonis Pulveratum 60g, too Fructus Jujubae 500g, Rhizoma Chuanxiong 90g are subsequent use;

Embodiment 55

Embodiment 56

Embodiment 57

Embodiment 58

Embodiment 59

Embodiment 60

C. add an amount of vegetable oil to said mixture, add volatile oil such as the Radix Aucklandiae again, mixing is processed soft capsule, promptly gets.]

Embodiment 61

Embodiment 62

Embodiment 63

Embodiment 64

B. above ten flavor medicines, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is subsequent use; Six-element medicated powder such as Lignum Aquilariae Resinatum, the Radix Aucklandiae, Lignum Santali Albi, Fructus Aurantii Immaturus, Cortex Magnoliae Officinalis, Rhizoma Chuanxiong are broken into coarse powder, add 16 times of water gagings, soak 4 hours, and decocting boils distillation 8h altogether, collects volatile oil, and is after β-CD inclusion, subsequent use; Decocting liquid filters, and relative density 1.25-1.30 was subsequent use when filtrating was concentrated into 60 ℃, and medicinal residues and Rhizoma Coptidis or Radix Scutellariae coarse powder add 70% alcohol reflux 2 times, for the first time 2h; 1h filters for the second time; Merge secondary filtrating, relative density 1.20-1.25 when being concentrated into 60 ℃, drying, subsequent use; Get Fructus Jujubae, add decocting and boil secondary, each 2h filters; Merge secondary filtrating, relative density 1.28-1.32 when being concentrated into 60 ℃, in dry,,, must the hybrid medicine powder subsequent use with bag and thing, Semen Crotonis Pulveratum, Moschus mixing with the above-mentioned fine powder that is dried and crushed into;

Claims

1. method for preparing of treating the Chinese medicinal composition capsules of gastrointestinal disease is characterized in that step is following:

Perhaps above ten flavor medicines, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is subsequent use; The Radix Aucklandiae, Lignum Aquilariae Resinatum, Lignum Santali Albi, Fructus Aurantii, Cortex Magnoliae Officinalis, Rhizoma Chuanxiong, Radix Et Rhizoma Rhei are pulverized CO ₂Supercritical extraction; Get extract, add an amount of anhydrous alcohol solution, carry out enclose with an amount of β-CD, drying promptly gets clathrate, and is subsequent use; With the medicinal residues ethanol extraction secondary behind the above-mentioned supercritical extraction, merge secondary filtrating, reclaim ethanol and concentrate subsequent use; Get Fructus Jujubae decocte with water secondary, filter; Merging filtrate concentrates, and with above-mentioned alcohol extract condensed cream mixing, drying is ground into fine powder, with clathrate, Semen Crotonis Pulveratum, Moschus mixing, sieves again, and it is subsequent use to get the hybrid medicine powder;

Perhaps above ten flavor medicines, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is subsequent use; Six-element medicated powder such as Lignum Aquilariae Resinatum, the Radix Aucklandiae, Lignum Santali Albi, Fructus Aurantii, Cortex Magnoliae Officinalis, Rhizoma Chuanxiong are broken into coarse powder, add water, soak, and decocting boils distillation, collect volatile oil, and are behind β-CDBao He, subsequent use; Decocting liquid filters, and filtrating concentrates subsequent use, and medicinal residues and Radix Et Rhizoma Rhei coarse powder add alcohol reflux 2 times, filters; Merge secondary filtrating, concentrate, drying, subsequent use; Get Fructus Jujubae, add decocting and boil secondary, filter; Merge secondary filtrating, concentrate, drying, the above-mentioned fine powder that is dried and crushed into, with clathrate, Semen Crotonis Pulveratum, Moschus mixing, it is subsequent use to get the hybrid medicine powder;

2. the method for preparing of the Chinese medicinal composition capsules of the said treatment gastrointestinal disease of claim 1 is characterized in that step is following:

Perhaps above ten flavor medicines, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is subsequent use; Lignum Aquilariae Resinatum, the Radix Aucklandiae, Lignum Santali Albi, Fructus Aurantii, Cortex Magnoliae Officinalis, Rhizoma Chuanxiong, Radix Et Rhizoma Rhei powder are broken into 40-80 purpose powder, CO ₂Supercritical extraction, extracting pressure 5-40MPa, temperature 35-60 ℃, CO ₂Flow velocity 20-35L/h, extraction 2-5h; Get extract, add an amount of anhydrous alcohol solution,, adopt polishing to carry out enclose,, promptly get clathrate in 40 ℃ of vacuum dryings with an amount of β-CD, subsequent use; Medicinal residues behind the above-mentioned supercritical extraction are added 60% ethanol extraction secondary, merge secondary filtrating, relative density is that 1.25-1.30 is subsequent use when reclaiming ethanol to 60 ℃; Get Fructus Jujubae decocte with water secondary, each 2h filters; Merging filtrate, relative density 1.25-1.30 when being concentrated into 60 ℃, with above-mentioned alcohol extract condensed cream mixing, drying is ground into fine powder, again with clathrate, Semen Crotonis Pulveratum, Moschus mixing, crosses 80 mesh sieves, and it is subsequent use to get the hybrid medicine powder;

Perhaps above ten flavor medicines, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is subsequent use; Six-element medicated powder such as Lignum Aquilariae Resinatum, the Radix Aucklandiae, Lignum Santali Albi, Fructus Aurantii, Cortex Magnoliae Officinalis, Rhizoma Chuanxiong are broken into coarse powder, add 16 times of water gagings, soak 4 hours, and decocting boils distillation 8h altogether, collects volatile oil, and is behind β-CDBao He, subsequent use; Decocting liquid filters, and relative density 1.25-1.30 was subsequent use when filtrating was concentrated into 60 ℃, and medicinal residues and Radix Et Rhizoma Rhei coarse powder add 70% alcohol reflux 2 times, for the first time 2h; 1h filters for the second time; Merge secondary filtrating, relative density 1.20-1.25 when being concentrated into 60 ℃, drying, subsequent use; Get Fructus Jujubae, add decocting and boil secondary, each 2h filters; Merge secondary filtrating, relative density 1.28-1.32 when being concentrated into 60 ℃, drying, with the above-mentioned fine powder that is dried and crushed into, with clathrate, Semen Crotonis Pulveratum, Moschus mixing, it is subsequent use to get the hybrid medicine powder;

3. the method for preparing of the Chinese medicinal composition capsules of the said treatment gastrointestinal disease of claim 2 is characterized in that comprising the steps:

4. the method for preparing of the Chinese medicinal composition capsules of the arbitrary said treatment gastrointestinal disease of claim 1～3 is characterized in that Fructus Aurantii is a stir-baked Fructus Aurantii in bran; Cortex Magnoliae Officinalis is a Cortex Magnoliae Officinalis (processed with ginger); Fructus Jujubae is that Fructus Jujubae, the Moschus of enucleation is the artificial Moschus.