CN101757282B - Traditional Chinese medicine cataplasma for treating gastrointestinal diseases and preparation method thereof - Google Patents

Traditional Chinese medicine cataplasma for treating gastrointestinal diseases and preparation method thereof Download PDF

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CN101757282B
CN101757282B CN2008101544159A CN200810154415A CN101757282B CN 101757282 B CN101757282 B CN 101757282B CN 2008101544159 A CN2008101544159 A CN 2008101544159A CN 200810154415 A CN200810154415 A CN 200810154415A CN 101757282 B CN101757282 B CN 101757282B
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powder
moschus
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semen crotonis
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CN101757282A (en
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陈坚
王磊
袁学海
王伟
杨瑾
王春晨
郝忻
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Lerentang Pharmaceutical Factory Of Jinyao Darentang Group Co ltd
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Lerentang Pharmaceutical Factory of Tianjin Zhongxin Pharmaceutical Group Co Ltd
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    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
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    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
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Abstract

The invention relates to a traditional Chinese medicine cataplasma for treating gastrointestinal diseases and a preparation method thereof. The traditional Chinese medicine cataplasma is a patch prepared from tens of traditional Chinese herbs of costustoot, agilawood, fructus aurantii, sanders, rheum officinale, mangnolia officinalis, muak, defatted croton seed powder, date and ligusticum wallichii. The traditional Chinese medicine cataplasma is mainly used for treating diseases of acute diarrhea, irritable bowel syndrome and the like in clinic.

Description

A kind of Chinese medicine patcher of treating gastrointestinal disease and preparation method thereof
Technical field
The present invention relates to field of medicaments, particularly relate to a kind of Chinese medicine patcher of treating gastrointestinal disease and preparation method thereof.
Background technology
Diarrhoea can be divided into infectious and non-infectious two types.Infectious diarrhea is divided into bacterial infection and viral infection again; Noninfectious diarrhea then can be caused by the change of improper diet, food anaphylaxis, rule of life, abrupt change of climate even multiple reason such as nervous.Motherland's medical science thinks to have loose bowels and is meant that defecation frequency increases, feces is rare clearly, even like water sample.The major lesions of having loose bowels is taste and intestine and small intestine.Its pathogenesis has being invaded by exogenous pathogen, injury due to diet, seven emotions discord, damp internal resistance and internal organs weakness etc.The clinical findings damp is caused a disease has cold-damp and damp and hot branch.Spleen and stomach function expands, and to hinder be to be caused by multiple factor, has exopathogen influence, taste weakness itself, incoordination between the liver and spleen and kidney intestinal deficiency etc. all can cause spleen and stomach function not normal and have loose bowels.Survey data shows that diarrhoea sickness rate in urban population reaches 0.4 time/people, and the rural population sickness rate reaches 0.5 time/people.Though diarrhoea is minor illness, pathogenic factor also is diversified, and changes with epoch, environment.We can say that the diarrhoea of today and the diarrhoea before 20 years see that from pathogeny the change of essence has been arranged.Along with development of times, people's living standard attains the well-off standard basically, and sanitary condition is improved greatly; Diarrhoea ratio by bacterial infection causes is fewer and feweri, on the contrary, because rhythm of life is accelerated; Struggle for existence is fierce, and the functional diarrhea ratio that pressure causes greatly obviously rises.A research shows that the diarrhoeal diseases people of China about 30% needs antibiosis usually to treat, and 70% does not need should not use antibiotic therapy yet.Consumer also more and more notices the untoward reaction of products such as berberine, norfloxacin, and the harm that abuse of antibiotics brought.Diarrhoea market is except low side antibiotic products such as berberine, norfloxacin; Some non-antibiotic products have also been introduced in recent years; Such as dioctahedral smectite, Birid Triple Viable etc.; But be positioned at high-end consumer groups, for most of consumer groups, its price positioning does not conform to the consumption location of such minor illness of suffering from diarrhoea with consumer.Analysis expert thinks, urban market diarrhoea mainly be with viral be main, be main in the rural area with bacterial infection, if according to the principle of the market segments, at present a lot of products all are difficult to cover the whole market.For alteration of intestinal flora person, available little ecological active bacteria formulation provides probiotics, improves intestinal environment, improves intestinal absorption, kinestate.As: bifidobacteria viable bacteria preparation (the happy capsule of beautiful pearl intestinal), Birid Triple Viable capsule, bacillus cicheniformis (whole intestinal rubber capsule); The intestinal mucosa protective agent: two eight body Montmorillonitums (dioctahedral smectite), the protection intestinal mucosa can suppress fixedly mycin, promotes the intestinal mucosal lesion reparation; Contain the creosote component preparation: the excessive secretion that can suppress intestinal juice.
At present on the market gastrointestinal disease treating pill is mainly used in treatment diarrhoea, enteritis, and bacillary dysentery, distension and fullness in the abdomen, stomachache, the food stagnation infantile dyspepsia, its pharmacological action is higher than like product: diarrhea, antibiotic, antiviral, four kinds of functions of adjusting gastrointestinal function are also deposited.But contain Cinnabaris in its prescription; Its effect is a tranquillizing the mind by relieving convulsion; But contain hydrargyrum in the Cinnabaris; Hydrargyrum is very big to the harm of human body, and it is the process of a subtle lasting absorption, and human body contacts hydrargyrum for a long time can cause chronic poisoning: nerve, digestion, hormonal system and kidney to the people produce harm; Neurasthenic crowd may cause symptoms such as headache, dizziness, insomnia, hypomnesis, malaise; And anemia of pregnant woman and the women of age of sucking contact hydrargyrum for a long time, also possibly endanger fetus and baby's health.Mercurous in addition medicine has received certain restriction when exporting other countries, require mercury content to require then strict more for some European countries less than 0.5ppm like Singapore.
Summary of the invention
The purpose of this invention is to provide a kind of Chinese medicine patcher of treating gastrointestinal disease.
Another object of the present invention provides a kind of method for preparing of treating the Chinese medicine patcher of gastrointestinal disease.
The Chinese medicine patcher that the present invention treats gastrointestinal disease is to be processed by the Radix Aucklandiae, Lignum Aquilariae Resinatum, Fructus Aurantii, Lignum Santali Albi, Radix Et Rhizoma Rhei, Cortex Magnoliae Officinalis, Moschus, Semen Crotonis Pulveratum, Fructus Jujubae, Rhizoma Chuanxiong ten flavor flavour of a drug.Pharmaceutical composition of the present invention has been selected Lignum Aquilariae Resinatum, Lignum Santali Albi, Radix Aucklandiae removing dampness by means of aromatics, regulating QI to relieve pain, non-return, the invigorating the spleen to arrest diarrhea of sending down the abnormal ascending QI for use to the pathogeny of having loose bowels.Wherein Lignum Aquilariae Resinatum sending down the abnormal ascending QI, Lignum Santali Albi rise gas, the Radix Aucklandiae is longer than the stagnant gas of capable the intestines and stomach.Three medicine mutual reinforcements between are for using stasis, promoting the circulation of QI to relieve pain, reason spleen antidiarrheal, removing dampness by means of aromatics, the expelling cold to relieve vomiting of function of spleen and stomach regulating intestine and small intestine effectively.Be aided with Fructus Aurantii, Cortex Magnoliae Officinalis, the painful abdominal mass removing dampness that disappears of regulating the flow of vital energy is loose long-pendingly, and intestinal stasis relieving helps digestion, and is equipped with gas medicine in the Rhizoma Chuanxiong fortune blood with blood-activating and qi-promoting.The six hollow viscera must keep its unobstructed, also the disease of having loose bowels itself also is a kind of function of human body self-protection.Invade as pathogenic factor, blindness antidiarrheal was closed door and is stayed Kou Zhiyu when dyspepsia was stagnated, so we have selected for use Radix Et Rhizoma Rhei, Semen Crotonis Pulveratum with stasis removing; Radix Et Rhizoma Rhei bitter cold, Semen Crotonis Pulveratum are hot; Two medicine fit applications have promptly been avoided the too numbness of cold and heat, have strengthened stasis removing again and have removed evil malicious the stagnating of delaying at enteral.This treating incontinent symptoms (pseudomorph) by dredging method reach the purpose that toxin expelling antidiarrheal is not stayed poison from method of treatment.This also is our most important character.Be equipped with the Fructus Jujubae spleen reinforcing, relax the property of medicine.All medicines share, with reach eliminating turbid pathogen with aromatics, regulating QI to relieve pain, the effect of the intestinal stasis relieving that is good for the stomach, with the treatment turbid damp obstructing in middle-JIAO, the diarrhoea due to dyspepsia is not changed, poor appetite, feel sick, diseases such as vomiting, abdominal distention, stomachache, dyspepsia, enteritis, bacillary dysentery, viral diarrhea.
The present invention treats the Chinese medicine patcher of gastrointestinal disease, can adopt following method to prepare active component for crude drug: like one or several Combined application preparations in extraction, water extraction, decoction and alcohol sedimentation technique, extraction, infusion process, percolation, reflux extraction, continuous backflow extraction method, the macroreticular resin absorbing method.But in order to make each crude drug of this medicine bring into play drug effect better, the present invention preferably adopts following technology to extract active component to raw material, and processes the Chinese medicine patcher that the present invention treats gastrointestinal disease, but this can not limit protection scope of the present invention.
The present invention treats the Chinese medicine patcher of gastrointestinal disease, and employing is prepared as follows method and processes:
A. take off column weight amount proportioning crude drug: the Radix Aucklandiae 150~600g, Lignum Aquilariae Resinatum 150~600g, Fructus Aurantii 150~600g, Lignum Santali Albi 90~360g, Radix Et Rhizoma Rhei 90~360g, Cortex Magnoliae Officinalis 150~600g, Moschus 4.5~18g, Semen Crotonis Pulveratum 60~240g, Fructus Jujubae 500~2000g, Rhizoma Chuanxiong 90~360g are subsequent use;
B. above ten flavor medicines, Semen Crotonis Pulveratum, Moschus pulverize separately become fine powder; The Radix Aucklandiae, Lignum Aquilariae Resinatum, Fructus Aurantii, Lignum Santali Albi, Radix Et Rhizoma Rhei, Cortex Magnoliae Officinalis, Fructus Jujubae, Rhizoma Chuanxiong eight flavors are ground into fine powder; With Semen Crotonis Pulveratum, Moschus powder facing-up, mixing sieves, and is subsequent use;
Perhaps above ten flavor medicines, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is subsequent use; The Radix Aucklandiae, Lignum Aquilariae Resinatum, Lignum Santali Albi, Fructus Aurantii Immaturus, Cortex Magnoliae Officinalis, Rhizoma Chuanxiong, Rhizoma Coptidis or Radix Scutellariae are pulverized, CO 2Supercritical extraction; Get extract, add an amount of anhydrous alcohol solution, carry out enclose with an amount of β-CD, drying promptly gets clathrate, and is subsequent use; With the medicinal residues ethanol extraction secondary behind the above-mentioned supercritical extraction, merge secondary filtrating, reclaim ethanol and concentrate subsequent use; Get Fructus Jujubae decocte with water secondary, filter; Merging filtrate concentrates, and with above-mentioned alcohol extract condensed cream mixing, drying is ground into fine powder, with clathrate, Semen Crotonis Pulveratum, Moschus mixing, sieves again, and is subsequent use;
Perhaps above ten flavor medicines, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is subsequent use; Six-element medicated powder such as Lignum Aquilariae Resinatum, the Radix Aucklandiae, Lignum Santali Albi, Fructus Aurantii Immaturus, Cortex Magnoliae Officinalis, Rhizoma Chuanxiong are broken into coarse powder, add water, soak, and decocting boils distillation, collect volatile oil, and are after β-CD inclusion, subsequent use; Decocting liquid filters, and filtrating concentrates subsequent use, and medicinal residues and Rhizoma Coptidis or Radix Scutellariae coarse powder add alcohol reflux 2 times, filters; Merge secondary filtrating, concentrate, drying, subsequent use; Get Fructus Jujubae, add decocting and boil secondary, filter; Merge secondary filtrating, concentrate, drying, the above-mentioned fine powder that is dried and crushed into, with bag and thing, Semen Crotonis Pulveratum, Moschus mixing, subsequent use;
Perhaps get the Radix Aucklandiae, Lignum Aquilariae Resinatum, Lignum Santali Albi, Fructus Aurantii, Cortex Magnoliae Officinalis, Rhizoma Chuanxiong, Radix Et Rhizoma Rhei powder and be broken into coarse powder, add alcohol reflux, filter; Merging filtrate, subsequent use; The concentrating under reduced pressure alcohol extract concentrates subsequent use; Get Fructus Jujubae, add decocting and boil, filter, concentrating under reduced pressure Fructus Jujubae water extract, the simmer down to clear paste, subsequent use; With above-mentioned gained clear paste drying under reduced pressure, getting dry extract is ground into fine powder and Semen Crotonis Pulveratum, Moschus mixing, sieves, subsequent use;
Perhaps above ten flavors, Semen Crotonis Pulveratum, Moschus pulverize separately become fine powder; All the other eight flavor medicine decocte with water 1~3 time, each 1~3 hour, collecting decoction filtered, and is condensed into thick paste; In above-mentioned thick paste, add Semen Crotonis Pulveratum, Moschus powder, mixing, subsequent use;
Get above-mentioned arbitrary hybrid medicine powder, add glycerol, Al (OH) 3, the PAA mix homogeneously is component A; Get tartaric acid, add distilled water, acrylate copolymer, dissolving is B component; B component slowly adds among the component A, stirs, and is coated with, and is compound with protecting film, cuts promptly to get.
The present invention preferably treats the Chinese medicine patcher of gastrointestinal disease, and employing is prepared as follows method and processes:
A. take off column weight amount proportioning crude drug: the Radix Aucklandiae 250~400g, Lignum Aquilariae Resinatum 250~400g, Fructus Aurantii 250~400g, Lignum Santali Albi 150~250g, Radix Et Rhizoma Rhei 150~250g, Cortex Magnoliae Officinalis 250~400g, Moschus 6~12g, Semen Crotonis Pulveratum 100~150g, Fructus Jujubae 800~1200g, Rhizoma Chuanxiong 150~250g are subsequent use;
B. above ten flavor medicines, Semen Crotonis Pulveratum, Moschus pulverize separately become fine powder; The Radix Aucklandiae, Lignum Aquilariae Resinatum, Fructus Aurantii, Lignum Santali Albi, Radix Et Rhizoma Rhei, Cortex Magnoliae Officinalis, Fructus Jujubae, Rhizoma Chuanxiong eight flavors are ground into fine powder; With Semen Crotonis Pulveratum, Moschus powder facing-up, mixing sieves, and is subsequent use;
Perhaps above ten flavor medicines, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is subsequent use; The Radix Aucklandiae, Lignum Aquilariae Resinatum, Lignum Santali Albi, Fructus Aurantii Immaturus, Cortex Magnoliae Officinalis, Rhizoma Chuanxiong, Rhizoma Coptidis or Radix Scutellariae are pulverized, CO 2Supercritical extraction; Get extract, add an amount of anhydrous alcohol solution, carry out enclose with an amount of β-CD, drying promptly gets clathrate, and is subsequent use; With the medicinal residues ethanol extraction secondary behind the above-mentioned supercritical extraction, merge secondary filtrating, reclaim ethanol and concentrate subsequent use; Get Fructus Jujubae decocte with water secondary, filter; Merging filtrate concentrates, and with above-mentioned alcohol extract condensed cream mixing, drying is ground into fine powder, with clathrate, Semen Crotonis Pulveratum, Moschus mixing, sieves again, and is subsequent use;
Perhaps above ten flavor medicines, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is subsequent use; Six-element medicated powder such as Lignum Aquilariae Resinatum, the Radix Aucklandiae, Lignum Santali Albi, Fructus Aurantii Immaturus, Cortex Magnoliae Officinalis, Rhizoma Chuanxiong are broken into coarse powder, add water, soak, and decocting boils distillation, collect volatile oil, and are after β-CD inclusion, subsequent use; Decocting liquid filters, and filtrating concentrates subsequent use, and medicinal residues and Rhizoma Coptidis or Radix Scutellariae coarse powder add alcohol reflux 2 times, filters; Merge secondary filtrating, concentrate, drying, subsequent use; Get Fructus Jujubae, add decocting and boil secondary, filter; Merge secondary filtrating, concentrate, drying, the above-mentioned fine powder that is dried and crushed into, with bag and thing, Semen Crotonis Pulveratum, Moschus mixing, subsequent use;
Perhaps get the Radix Aucklandiae, Lignum Aquilariae Resinatum, Lignum Santali Albi, Fructus Aurantii, Cortex Magnoliae Officinalis, Rhizoma Chuanxiong, Radix Et Rhizoma Rhei powder and be broken into coarse powder, add alcohol reflux, filter; Merging filtrate, subsequent use; The concentrating under reduced pressure alcohol extract concentrates subsequent use; Get Fructus Jujubae, add decocting and boil, filter, concentrating under reduced pressure Fructus Jujubae water extract, the simmer down to clear paste, subsequent use; With above-mentioned gained clear paste drying under reduced pressure, getting dry extract is ground into fine powder and Semen Crotonis Pulveratum, Moschus mixing, sieves, subsequent use;
Perhaps above ten flavors, Semen Crotonis Pulveratum, Moschus pulverize separately become fine powder; All the other eight flavor medicine decocte with water 1~3 time, each 1~3 hour, collecting decoction filtered, and is condensed into thick paste; In above-mentioned thick paste, add Semen Crotonis Pulveratum, Moschus powder, mixing, subsequent use;
Get above-mentioned arbitrary hybrid medicine powder, add glycerol, Al (OH) 3, the PAA mix homogeneously is component A; Get tartaric acid, add distilled water, acrylate copolymer, dissolving is B component; B component slowly adds among the component A, stirs, and is coated with, and is compound with protecting film, cuts promptly to get.
The Chinese medicine patcher of the further preferred treatment gastrointestinal disease of the present invention, employing is prepared as follows method and processes:
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 300g, Lignum Aquilariae Resinatum 300g, Fructus Aurantii 300g, Lignum Santali Albi 180g, Radix Et Rhizoma Rhei 180g, Cortex Magnoliae Officinalis 300g, Moschus 9g, Semen Crotonis Pulveratum 120g, Fructus Jujubae 1000g, Rhizoma Chuanxiong 180g are subsequent use;
B. above ten flavor medicines, Semen Crotonis Pulveratum, Moschus pulverize separately become fine powder; The Radix Aucklandiae, Lignum Aquilariae Resinatum, Fructus Aurantii, Lignum Santali Albi, Radix Et Rhizoma Rhei, Cortex Magnoliae Officinalis, Fructus Jujubae, Rhizoma Chuanxiong eight flavors are ground into fine powder; With Semen Crotonis Pulveratum, Moschus powder facing-up, mixing sieves, and is subsequent use;
Perhaps above ten flavor medicines, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is subsequent use; The Radix Aucklandiae, Lignum Aquilariae Resinatum, Lignum Santali Albi, Fructus Aurantii Immaturus, Cortex Magnoliae Officinalis, Rhizoma Chuanxiong, Rhizoma Coptidis or Radix Scutellariae are pulverized, CO 2Supercritical extraction; Get extract, add an amount of anhydrous alcohol solution, carry out enclose with an amount of β-CD, drying promptly gets clathrate, and is subsequent use; With the medicinal residues ethanol extraction secondary behind the above-mentioned supercritical extraction, merge secondary filtrating, reclaim ethanol and concentrate subsequent use; Get Fructus Jujubae decocte with water secondary, filter; Merging filtrate concentrates, and with above-mentioned alcohol extract condensed cream mixing, drying is ground into fine powder, with clathrate, Semen Crotonis Pulveratum, Moschus mixing, sieves again, and is subsequent use;
Perhaps above ten flavor medicines, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is subsequent use; Six-element medicated powder such as Lignum Aquilariae Resinatum, the Radix Aucklandiae, Lignum Santali Albi, Fructus Aurantii Immaturus, Cortex Magnoliae Officinalis, Rhizoma Chuanxiong are broken into coarse powder, add water, soak, and decocting boils distillation, collect volatile oil, and are after β-CD inclusion, subsequent use; Decocting liquid filters, and filtrating concentrates subsequent use, and medicinal residues and Rhizoma Coptidis or Radix Scutellariae coarse powder add alcohol reflux 2 times, filters; Merge secondary filtrating, concentrate, drying, subsequent use; Get Fructus Jujubae, add decocting and boil secondary, filter; Merge secondary filtrating, concentrate, drying, the above-mentioned fine powder that is dried and crushed into, with bag and thing, Semen Crotonis Pulveratum, Moschus mixing, subsequent use;
Perhaps get the Radix Aucklandiae, Lignum Aquilariae Resinatum, Lignum Santali Albi, Fructus Aurantii, Cortex Magnoliae Officinalis, Rhizoma Chuanxiong, Radix Et Rhizoma Rhei powder and be broken into coarse powder, add alcohol reflux, filter; Merging filtrate, subsequent use; The concentrating under reduced pressure alcohol extract concentrates subsequent use; Get Fructus Jujubae, add decocting and boil, filter, concentrating under reduced pressure Fructus Jujubae water extract, the simmer down to clear paste, subsequent use; With above-mentioned gained clear paste drying under reduced pressure, getting dry extract is ground into fine powder and Semen Crotonis Pulveratum, Moschus mixing, sieves, subsequent use;
Perhaps above ten flavors, Semen Crotonis Pulveratum, Moschus pulverize separately become fine powder; All the other eight flavor medicine decocte with water 1~3 time, each 1~3 hour, collecting decoction filtered, and is condensed into thick paste; In above-mentioned thick paste, add Semen Crotonis Pulveratum, Moschus powder, mixing, subsequent use;
Get above-mentioned arbitrary hybrid medicine powder 2869g, add glycerol 13770g, Al (OH) 3183g, PAA 2754g mix homogeneously are component A; Get tartaric acid 92g, add distilled water 27540g, acrylate copolymer 1836g, dissolving is B component; B component slowly adds among the component A, stirs, and is coated with, and is compound with protecting film, cuts promptly to get.
The present invention treats in the Chinese medicine patcher of gastrointestinal disease, and the Fructus Aurantii among the step a is a stir-baked Fructus Aurantii in bran; Cortex Magnoliae Officinalis is a Cortex Magnoliae Officinalis (processed with ginger); Fructus Jujubae is that Fructus Jujubae, the Moschus of enucleation is the artificial Moschus.
The present invention treats the method for preparing of the Chinese medicine patcher of gastrointestinal disease, and step is following:
A. take off column weight amount proportioning crude drug: the Radix Aucklandiae 150~600g, Lignum Aquilariae Resinatum 150~600g, Fructus Aurantii 150~600g, Lignum Santali Albi 90~360g, Radix Et Rhizoma Rhei 90~360g, Cortex Magnoliae Officinalis 150~600g, Moschus 4.5~18g, Semen Crotonis Pulveratum 60~240g, Fructus Jujubae 500~2000g, Rhizoma Chuanxiong 90~360g are subsequent use;
B. above ten flavor medicines, Semen Crotonis Pulveratum, Moschus pulverize separately become fine powder; The Radix Aucklandiae, Lignum Aquilariae Resinatum, Fructus Aurantii, Lignum Santali Albi, Radix Et Rhizoma Rhei, Cortex Magnoliae Officinalis, Fructus Jujubae, Rhizoma Chuanxiong eight flavors are ground into fine powder; With Semen Crotonis Pulveratum, Moschus powder facing-up, mixing sieves, and is subsequent use;
Perhaps above ten flavor medicines, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is subsequent use; The Radix Aucklandiae, Lignum Aquilariae Resinatum, Lignum Santali Albi, Fructus Aurantii Immaturus, Cortex Magnoliae Officinalis, Rhizoma Chuanxiong, Rhizoma Coptidis or Radix Scutellariae are pulverized, CO 2Supercritical extraction; Get extract, add an amount of anhydrous alcohol solution, carry out enclose with an amount of β-CD, drying promptly gets clathrate, and is subsequent use; With the medicinal residues ethanol extraction secondary behind the above-mentioned supercritical extraction, merge secondary filtrating, reclaim ethanol and concentrate subsequent use; Get Fructus Jujubae decocte with water secondary, filter; Merging filtrate concentrates, and with above-mentioned alcohol extract condensed cream mixing, drying is ground into fine powder, with clathrate, Semen Crotonis Pulveratum, Moschus mixing, sieves again, and is subsequent use;
Perhaps above ten flavor medicines, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is subsequent use; Six-element medicated powder such as Lignum Aquilariae Resinatum, the Radix Aucklandiae, Lignum Santali Albi, Fructus Aurantii Immaturus, Cortex Magnoliae Officinalis, Rhizoma Chuanxiong are broken into coarse powder, add water, soak, and decocting boils distillation, collect volatile oil, and are after β-CD inclusion, subsequent use; Decocting liquid filters, and filtrating concentrates subsequent use, and medicinal residues and Rhizoma Coptidis or Radix Scutellariae coarse powder add alcohol reflux 2 times, filters; Merge secondary filtrating, concentrate, drying, subsequent use; Get Fructus Jujubae, add decocting and boil secondary, filter; Merge secondary filtrating, concentrate, drying, the above-mentioned fine powder that is dried and crushed into, with bag and thing, Semen Crotonis Pulveratum, Moschus mixing, subsequent use;
Perhaps get the Radix Aucklandiae, Lignum Aquilariae Resinatum, Lignum Santali Albi, Fructus Aurantii, Cortex Magnoliae Officinalis, Rhizoma Chuanxiong, Radix Et Rhizoma Rhei powder and be broken into coarse powder, add alcohol reflux, filter; Merging filtrate, subsequent use; The concentrating under reduced pressure alcohol extract concentrates subsequent use; Get Fructus Jujubae, add decocting and boil, filter, concentrating under reduced pressure Fructus Jujubae water extract, the simmer down to clear paste, subsequent use; With above-mentioned gained clear paste drying under reduced pressure, getting dry extract is ground into fine powder and Semen Crotonis Pulveratum, Moschus mixing, sieves, subsequent use;
Perhaps above ten flavors, Semen Crotonis Pulveratum, Moschus pulverize separately become fine powder; All the other eight flavor medicine decocte with water 1~3 time, each 1~3 hour, collecting decoction filtered, and is condensed into thick paste; In above-mentioned thick paste, add Semen Crotonis Pulveratum, Moschus powder, mixing, subsequent use;
Get above-mentioned arbitrary hybrid medicine powder, add glycerol, Al (OH) 3, the PAA mix homogeneously is component A; Get tartaric acid, add distilled water, acrylate copolymer, dissolving is B component; B component slowly adds among the component A, stirs, and is coated with, and is compound with protecting film, cuts promptly to get.
The present invention preferably treats the method for preparing of the Chinese medicine patcher of gastrointestinal disease, and step is following:
A. take off column weight amount proportioning crude drug: the Radix Aucklandiae 250~400g, Lignum Aquilariae Resinatum 250~400g, Fructus Aurantii 250~400g, Lignum Santali Albi 150~250g, Radix Et Rhizoma Rhei 150~250g, Cortex Magnoliae Officinalis 250~400g, Moschus 6~12g, Semen Crotonis Pulveratum 100~150g, Fructus Jujubae 800~1200g, Rhizoma Chuanxiong 150~250g are subsequent use;
B. above ten flavor medicines, Semen Crotonis Pulveratum, Moschus pulverize separately become fine powder; The Radix Aucklandiae, Lignum Aquilariae Resinatum, Fructus Aurantii, Lignum Santali Albi, Radix Et Rhizoma Rhei, Cortex Magnoliae Officinalis, Fructus Jujubae, Rhizoma Chuanxiong eight flavors are ground into fine powder; With Semen Crotonis Pulveratum, Moschus powder facing-up, mixing sieves, and is subsequent use;
Perhaps above ten flavor medicines, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is subsequent use; The Radix Aucklandiae, Lignum Aquilariae Resinatum, Lignum Santali Albi, Fructus Aurantii Immaturus, Cortex Magnoliae Officinalis, Rhizoma Chuanxiong, Rhizoma Coptidis or Radix Scutellariae are pulverized, CO 2Supercritical extraction; Get extract, add an amount of anhydrous alcohol solution, carry out enclose with an amount of β-CD, drying promptly gets clathrate, and is subsequent use; With the medicinal residues ethanol extraction secondary behind the above-mentioned supercritical extraction, merge secondary filtrating, reclaim ethanol and concentrate subsequent use; Get Fructus Jujubae decocte with water secondary, filter; Merging filtrate concentrates, and with above-mentioned alcohol extract condensed cream mixing, drying is ground into fine powder, with clathrate, Semen Crotonis Pulveratum, Moschus mixing, sieves again, and is subsequent use;
Perhaps above ten flavor medicines, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is subsequent use; Six-element medicated powder such as Lignum Aquilariae Resinatum, the Radix Aucklandiae, Lignum Santali Albi, Fructus Aurantii Immaturus, Cortex Magnoliae Officinalis, Rhizoma Chuanxiong are broken into coarse powder, add water, soak, and decocting boils distillation, collect volatile oil, and are after β-CD inclusion, subsequent use; Decocting liquid filters, and filtrating concentrates subsequent use, and medicinal residues and Rhizoma Coptidis or Radix Scutellariae coarse powder add alcohol reflux 2 times, filters; Merge secondary filtrating, concentrate, drying, subsequent use; Get Fructus Jujubae, add decocting and boil secondary, filter; Merge secondary filtrating, concentrate, drying, the above-mentioned fine powder that is dried and crushed into, with bag and thing, Semen Crotonis Pulveratum, Moschus mixing, subsequent use;
Perhaps get the Radix Aucklandiae, Lignum Aquilariae Resinatum, Lignum Santali Albi, Fructus Aurantii, Cortex Magnoliae Officinalis, Rhizoma Chuanxiong, Radix Et Rhizoma Rhei powder and be broken into coarse powder, add alcohol reflux, filter; Merging filtrate, subsequent use; The concentrating under reduced pressure alcohol extract concentrates subsequent use; Get Fructus Jujubae, add decocting and boil, filter, concentrating under reduced pressure Fructus Jujubae water extract, the simmer down to clear paste, subsequent use; With above-mentioned gained clear paste drying under reduced pressure, getting dry extract is ground into fine powder and Semen Crotonis Pulveratum, Moschus mixing, sieves, subsequent use;
Perhaps above ten flavors, Semen Crotonis Pulveratum, Moschus pulverize separately become fine powder; All the other eight flavor medicine decocte with water 1~3 time, each 1~3 hour, collecting decoction filtered, and is condensed into thick paste; In above-mentioned thick paste, add Semen Crotonis Pulveratum, Moschus powder, mixing, subsequent use;
Get above-mentioned arbitrary hybrid medicine powder, add glycerol, Al (OH) 3, the PAA mix homogeneously is component A; Get tartaric acid, add distilled water, acrylate copolymer, dissolving is B component; B component slowly adds among the component A, stirs, and is coated with, and is compound with protecting film, cuts promptly to get.
The method for preparing of the Chinese medicine patcher of the further preferred treatment gastrointestinal disease of the present invention, step is following:
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 300g, Lignum Aquilariae Resinatum 300g, Fructus Aurantii 300g, Lignum Santali Albi 180g, Radix Et Rhizoma Rhei 180g, Cortex Magnoliae Officinalis 300g, Moschus 9g, Semen Crotonis Pulveratum 120g, Fructus Jujubae 1000g, Rhizoma Chuanxiong 180g are subsequent use;
B. above ten flavor medicines, Semen Crotonis Pulveratum, Moschus pulverize separately become fine powder; The Radix Aucklandiae, Lignum Aquilariae Resinatum, Fructus Aurantii, Lignum Santali Albi, Radix Et Rhizoma Rhei, Cortex Magnoliae Officinalis, Fructus Jujubae, Rhizoma Chuanxiong eight flavors are ground into fine powder; With Semen Crotonis Pulveratum, Moschus powder facing-up, mixing sieves, and is subsequent use;
Perhaps above ten flavor medicines, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is subsequent use; The Radix Aucklandiae, Lignum Aquilariae Resinatum, Lignum Santali Albi, Fructus Aurantii Immaturus, Cortex Magnoliae Officinalis, Rhizoma Chuanxiong, Rhizoma Coptidis or Radix Scutellariae are pulverized, CO 2Supercritical extraction; Get extract, add an amount of anhydrous alcohol solution, carry out enclose with an amount of β-CD, drying promptly gets clathrate, and is subsequent use; With the medicinal residues ethanol extraction secondary behind the above-mentioned supercritical extraction, merge secondary filtrating, reclaim ethanol and concentrate subsequent use; Get Fructus Jujubae decocte with water secondary, filter; Merging filtrate concentrates, and with above-mentioned alcohol extract condensed cream mixing, drying is ground into fine powder, with clathrate, Semen Crotonis Pulveratum, Moschus mixing, sieves again, and is subsequent use;
Perhaps above ten flavor medicines, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is subsequent use; Six-element medicated powder such as Lignum Aquilariae Resinatum, the Radix Aucklandiae, Lignum Santali Albi, Fructus Aurantii Immaturus, Cortex Magnoliae Officinalis, Rhizoma Chuanxiong are broken into coarse powder, add water, soak, and decocting boils distillation, collect volatile oil, and are after β-CD inclusion, subsequent use; Decocting liquid filters, and filtrating concentrates subsequent use, and medicinal residues and Rhizoma Coptidis or Radix Scutellariae coarse powder add alcohol reflux 2 times, filters; Merge secondary filtrating, concentrate, drying, subsequent use; Get Fructus Jujubae, add decocting and boil secondary, filter; Merge secondary filtrating, concentrate, drying, the above-mentioned fine powder that is dried and crushed into, with bag and thing, Semen Crotonis Pulveratum, Moschus mixing, subsequent use;
Perhaps get the Radix Aucklandiae, Lignum Aquilariae Resinatum, Lignum Santali Albi, Fructus Aurantii, Cortex Magnoliae Officinalis, Rhizoma Chuanxiong, Radix Et Rhizoma Rhei powder and be broken into coarse powder, add alcohol reflux, filter; Merging filtrate, subsequent use; The concentrating under reduced pressure alcohol extract concentrates subsequent use; Get Fructus Jujubae, add decocting and boil, filter, concentrating under reduced pressure Fructus Jujubae water extract, the simmer down to clear paste, subsequent use; With above-mentioned gained clear paste drying under reduced pressure, getting dry extract is ground into fine powder and Semen Crotonis Pulveratum, Moschus mixing, sieves, subsequent use;
Perhaps above ten flavors, Semen Crotonis Pulveratum, Moschus pulverize separately become fine powder; All the other eight flavor medicine decocte with water 1~3 time, each 1~3 hour, collecting decoction filtered, and is condensed into thick paste; In above-mentioned thick paste, add Semen Crotonis Pulveratum, Moschus powder, mixing, subsequent use;
Get above-mentioned arbitrary hybrid medicine powder 2869g, add glycerol 13770g, Al (OH) 3183g, PAA 2754g mix homogeneously are component A; Get tartaric acid 92g, add distilled water 27540g, acrylate copolymer 1836g, dissolving is B component; B component slowly adds among the component A, stirs, and is coated with, and is compound with protecting film, cuts promptly to get.
The present invention treats the application of Chinese medicine patcher in preparation treatment irritable bowel syndrome medicine of gastrointestinal disease.
The Chinese medicine patcher that the present invention treats gastrointestinal disease at preparation treatment diarrhoea, poor appetite, feel sick, the application in the vomiting, abdominal distention, stomachache, dyspepsia, dysentery, enteritis, functional gastrointestinal disease medicine.
More than form when producing and to increase or to reduce according to corresponding ratio; Like large-scale production can be unit with kilogram or with the ton; Small-scale production can be unit with the gram also, and weight can increase or reduce, but the crude drug material weight proportion constant rate between each composition.
Chinese medicine patcher of the present invention has the following advantages:
1, non-stimulated to skin, there is not irritated phenomenon, have that Transdermal absorption is fast, good permeability and a progressively release, advantage such as easy to use;
2, pollution clothes not can also paste in the time of need taking off during sticking again;
3, drug loading is big, and is good to the medicine intermiscibility, and the suitable Chinese medical concrete that adds of medicine and substrate is processed Chinese medicine patcher.
4, pharmaceutical properties, host material stable in properties, and with low cost;
5, peel strength and to hold viscous force all more satisfactory;
6, method for preparing is simple relatively;
7, compare with peroral dosage form, no liver sausage first-pass effect is not influenced by the gastrointestinal tract degraded, and bioavailability is high; Compare with injection, easy to use, no pain is compared with ointment, and dosage is accurate, and absorption area is fixed.
In order to understand the present invention better, logical below Test Example is further set forth the beneficial effect of medicine of the present invention.Below used medicine of the present invention for the ease of narration, below will be called for short medicine of the present invention according to the medicine of embodiment 6 methods preparation according to the preparation of embodiment 6 methods in the test.
Medicine percutaneous dosing treatment irritable boewl syndrome 47 examples of the present invention
1 data and method
1.1 physical data reference 1999 (FGID) is referring to the diagnostic criteria in the II diagnostic criteria of Rome.Case selects hepatic and renal function, erythrocyte sedimentation rate, thyroid profile biochemical analysis normal, and stool inspection and fibercolonscopy are got rid of infectious and ND patient 47 examples.Wherein male 25 examples, women 22 examples; 38 years old mean age, course of disease 2-15, average 4.5 years; Diarrhea-type 32 examples, constipation type 15 examples.
1.2 Therapeutic Method
Patient's umbilical part is cleaned with normal saline, then medicine is pasted and the umbilicus position.Change dressings every day once, treating 20 days was 1 course of treatment.1.3 criterion of therapeutical effect is with reference to State Administration of Traditional Chinese Medicine " traditional Chinese medical science disease diagnosis criterion of therapeutical effect ", " have loose bowels, constipation " standard rating curative effect.Cure: stomachache, abdominal distention and autonomic nervous dysfunction's symptom and abdominal tenderness sign disappear.Diarrhea-type stool 1 time/day:, stool is shaped, defecation urgency sense and sense disappearance not to the utmost; Constipation type stool 1 time/day, stool is shaped and is unobstructed; Take a turn for the better: stomachache, abdominal distention and autonomic nervous dysfunction's symptom are clearly better, the abdominal tenderness sign alleviates.Diarrhea-type stool<3 times/day, the stool shape is loose, pasty state, mucus or watery stool all take a favorable turn, and the defecation urgency sense alleviates with feeling all having not to the utmost; Constipation type defecation>3 time/week, feces is hard or be the sheep stool shape and take a turn for the better, and defecation is than leicht fallen D/A.Invalid: symptom, sign do not have obvious improvement.
2 results: see table 1.
Table 1 curative effect of medication of the present invention is observed
Figure G2008101544159D00091
Table 2 Drug therapy of the present invention observation of curative effect after 3 months
Group Typing (routine number n) Cure Take a turn for the better Invalid Total effective rate (%)
The treatment group Diarrhea-type (34) 20 11 3 91.18
Constipation type (13) 6 5 2 84.62
The result shows that medicine of the present invention has good therapeutic effect.
The specific embodiment
Below further set forth the method for preparing of medicine of the present invention through embodiment.
Embodiment 1:
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 150g, Lignum Aquilariae Resinatum 150g, Fructus Aurantii 150g, Lignum Santali Albi 90g, Radix Et Rhizoma Rhei 90g, Cortex Magnoliae Officinalis 150g, Moschus 4.5g, Semen Crotonis Pulveratum 60g, Fructus Jujubae 500g, Rhizoma Chuanxiong 90g are subsequent use;
B. Semen Crotonis Pulveratum, Moschus pulverize separately become fine powder; The Radix Aucklandiae, Lignum Aquilariae Resinatum, Fructus Aurantii, Lignum Santali Albi, Radix Et Rhizoma Rhei, Cortex Magnoliae Officinalis, Fructus Jujubae, Rhizoma Chuanxiong eight flavors are ground into fine powder; With Semen Crotonis Pulveratum, Moschus powder facing-up, mixing sieves; Get above-mentioned hybrid medicine powder 569g, add glycerol 6000g, Al (OH) 380g, PAA 1500g mix homogeneously are component A; Get tartaric acid 40g, add distilled water 13500g, acrylate copolymer 800g, dissolving is B component; B component slowly adds among the component A, stirs, and is coated with, and is compound with protecting film, cuts promptly to get.
Embodiment 2:
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 600g, Lignum Aquilariae Resinatum 600g, Fructus Aurantii 600g, Lignum Santali Albi 360g, Radix Et Rhizoma Rhei 360g, Cortex Magnoliae Officinalis 600g, Moschus 18g, Semen Crotonis Pulveratum 240g, Fructus Jujubae 2000g, Rhizoma Chuanxiong 360g are subsequent use;
B. Semen Crotonis Pulveratum, Moschus pulverize separately become fine powder; The Radix Aucklandiae, Lignum Aquilariae Resinatum, Fructus Aurantii, Lignum Santali Albi, Radix Et Rhizoma Rhei, Cortex Magnoliae Officinalis, Fructus Jujubae, Rhizoma Chuanxiong eight flavors are ground into fine powder; With Semen Crotonis Pulveratum, Moschus powder facing-up, mixing sieves; Get above-mentioned hybrid medicine powder 4000g, add glycerol 23770g, Al (OH) 3153g, PAA 2754g mix homogeneously are component A; Get tartaric acid 72g, add distilled water 17540g, acrylate copolymer 1336g, dissolving is B component; B component slowly adds among the component A, stirs, and is coated with, and is compound with protecting film, cuts promptly to get.
Embodiment 3:
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 200g, Lignum Aquilariae Resinatum 150g, Fructus Aurantii 600g, Lignum Santali Albi 360g, Radix Et Rhizoma Rhei 90g, Cortex Magnoliae Officinalis 200g, Moschus 10g, Semen Crotonis Pulveratum 80g, Fructus Jujubae 1500g, Rhizoma Chuanxiong 300g are subsequent use;
B. Semen Crotonis Pulveratum, Moschus pulverize separately become fine powder; The Radix Aucklandiae, Lignum Aquilariae Resinatum, Fructus Aurantii, Lignum Santali Albi, Radix Et Rhizoma Rhei, Cortex Magnoliae Officinalis, Fructus Jujubae, Rhizoma Chuanxiong eight flavors are ground into fine powder; With Semen Crotonis Pulveratum, Moschus powder facing-up, mixing sieves; Get above-mentioned hybrid medicine powder 2500g, add glycerol 14000g, Al (OH) 3190g, PAA 2800g mix homogeneously are component A; Get tartaric acid 95g, add distilled water 30000g, acrylate copolymer 2500g, dissolving is B component; B component slowly adds among the component A, stirs, and is coated with, and is compound with protecting film, cuts promptly to get.
Embodiment 4:
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 250g, Lignum Aquilariae Resinatum 250g, Fructus Aurantii 250g, Lignum Santali Albi 150g, Radix Et Rhizoma Rhei 250g, Cortex Magnoliae Officinalis 250g, Moschus 6g, Semen Crotonis Pulveratum 100g, Fructus Jujubae 800g, Rhizoma Chuanxiong 150g are subsequent use;
B. Semen Crotonis Pulveratum, Moschus pulverize separately become fine powder; The Radix Aucklandiae, Lignum Aquilariae Resinatum, Fructus Aurantii, Lignum Santali Albi, Radix Et Rhizoma Rhei, Cortex Magnoliae Officinalis, Fructus Jujubae, Rhizoma Chuanxiong eight flavors are ground into fine powder; With Semen Crotonis Pulveratum, Moschus powder facing-up, mixing sieves; Get above-mentioned hybrid medicine powder 1800g, add glycerol 8000g, Al (OH) 345g, PAA 2000g mix homogeneously are component A; Get tartaric acid 90g, add distilled water 27000g, acrylate copolymer 1800g, dissolving is B component; B component slowly adds among the component A, stirs, and is coated with, and is compound with protecting film, cuts promptly to get.
Embodiment 5:
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 400g, Lignum Aquilariae Resinatum 400g, Fructus Aurantii 400g, Lignum Santali Albi 250g, Radix Et Rhizoma Rhei 250g, Cortex Magnoliae Officinalis 400g, artificial Moschus 12g, Semen Crotonis Pulveratum 150g, Fructus Jujubae 1200g, Rhizoma Chuanxiong 250g are subsequent use;
B. Semen Crotonis Pulveratum, Moschus pulverize separately become fine powder; The Radix Aucklandiae, Lignum Aquilariae Resinatum, Fructus Aurantii, Lignum Santali Albi, Radix Et Rhizoma Rhei, Cortex Magnoliae Officinalis, Fructus Jujubae, Rhizoma Chuanxiong eight flavors are ground into fine powder; With Semen Crotonis Pulveratum, Moschus powder facing-up, mixing sieves; Get above-mentioned hybrid medicine powder, add an amount of glycerol, Al (OH) 3, the PAA mix homogeneously is component A; Get an amount of tartaric acid, add an amount of distilled water, acrylate copolymer, dissolving is B component; B component slowly adds among the component A, stirs, and is coated with, and is compound with protecting film, cuts promptly to get.
Embodiment 6
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 300g, Lignum Aquilariae Resinatum 300g, Fructus Aurantii (parched with bran) 300g, Lignum Santali Albi 180g, Radix Et Rhizoma Rhei 180g, Cortex Magnoliae Officinalis (Rhizoma Zingiberis Recens is processed) 300g, artificial Moschus 9g, Semen Crotonis Pulveratum 120g, Fructus Jujubae (enucleation) 1000g, Rhizoma Chuanxiong 180g are subsequent use;
B. Semen Crotonis Pulveratum, Moschus pulverize separately become fine powder; The Radix Aucklandiae, Lignum Aquilariae Resinatum, Fructus Aurantii, Lignum Santali Albi, Radix Et Rhizoma Rhei, Cortex Magnoliae Officinalis, Fructus Jujubae, Rhizoma Chuanxiong eight flavors are ground into fine powder; With Semen Crotonis Pulveratum, Moschus powder facing-up, mixing sieves; Get above-mentioned hybrid medicine powder 2869g, add glycerol 13770g, Al (OH) 3183g, PAA 2754g mix homogeneously are component A; Get tartaric acid 92g, add distilled water 27540g, acrylate copolymer 1836g, dissolving is B component; B component slowly adds among the component A, stirs, and is coated with, and is compound with protecting film, cuts promptly to get.
Embodiment 7
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 250g, Lignum Aquilariae Resinatum 300g, Fructus Aurantii (parched with bran) 250g, Lignum Santali Albi 180g, Radix Et Rhizoma Rhei 180g, Cortex Magnoliae Officinalis (Rhizoma Zingiberis Recens is processed) 300g, Moschus 9g, Semen Crotonis Pulveratum 120g, Fructus Jujubae (enucleation) 1200g, Rhizoma Chuanxiong 180g are subsequent use;
B. Semen Crotonis Pulveratum, Moschus pulverize separately become fine powder; The Radix Aucklandiae, Lignum Aquilariae Resinatum, Fructus Aurantii, Lignum Santali Albi, Radix Et Rhizoma Rhei, Cortex Magnoliae Officinalis, Fructus Jujubae, Rhizoma Chuanxiong eight flavors are ground into fine powder; With Semen Crotonis Pulveratum, Moschus powder facing-up, mixing sieves; Get above-mentioned hybrid medicine powder 2869g, add glycerol 13510g, Al (OH) 3183g, PAA 2457g mix homogeneously are component A; Get tartaric acid 70g, add distilled water 25470g, acrylate copolymer 1638g, dissolving is B component; B component slowly adds among the component A, stirs, and is coated with, and is compound with protecting film, cuts promptly to get.
Embodiment 8
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 300g, Lignum Aquilariae Resinatum 300g, Fructus Aurantii 300g, Lignum Santali Albi 180g, Radix Et Rhizoma Rhei 180g, Cortex Magnoliae Officinalis 300g, Moschus 9g, Semen Crotonis Pulveratum 120g, Fructus Jujubae 1000g, Rhizoma Chuanxiong 180g are subsequent use;
B. Semen Crotonis Pulveratum, Moschus pulverize separately become fine powder; The Radix Aucklandiae, Lignum Aquilariae Resinatum, Fructus Aurantii, Lignum Santali Albi, Radix Et Rhizoma Rhei, Cortex Magnoliae Officinalis, Fructus Jujubae, Rhizoma Chuanxiong eight flavors are ground into fine powder; With Semen Crotonis Pulveratum, Moschus powder facing-up, mixing sieves; Get above-mentioned hybrid medicine powder 1500g, add glycerol 9000g, Al (OH) 335g, PAA 4500g mix homogeneously are component A; Get tartaric acid 50g, add distilled water 20000g, acrylate copolymer 1200g, dissolving is B component; B component slowly adds among the component A, stirs, and is coated with, and is compound with protecting film, cuts promptly to get.
Embodiment 9
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 300g, Lignum Aquilariae Resinatum 300g, Fructus Aurantii 300g, Lignum Santali Albi 180g, Radix Et Rhizoma Rhei 180g, Cortex Magnoliae Officinalis 300g, artificial Moschus 9g, Semen Crotonis Pulveratum 120g, Fructus Jujubae 1000g, Rhizoma Chuanxiong 180g are subsequent use;
B. Semen Crotonis Pulveratum, Moschus pulverize separately become fine powder; The Radix Aucklandiae, Lignum Aquilariae Resinatum, Fructus Aurantii, Lignum Santali Albi, Radix Et Rhizoma Rhei, Cortex Magnoliae Officinalis, Fructus Jujubae, Rhizoma Chuanxiong eight flavors are ground into fine powder; With Semen Crotonis Pulveratum, Moschus powder facing-up, mixing sieves; Get above-mentioned hybrid medicine powder 1509g, add glycerol 10370g, Al (OH) 380g, PAA 1500g mix homogeneously are component A; Get tartaric acid 200g, add distilled water 25000g, acrylate copolymer 2500g, dissolving is B component; B component slowly adds among the component A, stirs, and is coated with, and is compound with protecting film, cuts promptly to get.
Embodiment 10
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 300g, Lignum Aquilariae Resinatum 350g, Fructus Aurantii (parched with bran) 350g, Lignum Santali Albi 200g, Radix Et Rhizoma Rhei 200g, Cortex Magnoliae Officinalis (Rhizoma Zingiberis Recens is processed) 300g, Moschus 7g, Semen Crotonis Pulveratum 120g, Fructus Jujubae (enucleation) 1000g, Rhizoma Chuanxiong 200g are subsequent use;
B. Semen Crotonis Pulveratum, Moschus pulverize separately become fine powder; The Radix Aucklandiae, Lignum Aquilariae Resinatum, Fructus Aurantii, Lignum Santali Albi, Radix Et Rhizoma Rhei, Cortex Magnoliae Officinalis, Fructus Jujubae, Rhizoma Chuanxiong eight flavors are ground into fine powder; With Semen Crotonis Pulveratum, Moschus powder facing-up, mixing sieves; Get above-mentioned hybrid medicine powder 2200g, add glycerol 10000g, Al (OH) 3200g, PAA 3000g mix homogeneously are component A; Get tartaric acid 100g, add distilled water 25740g, acrylate copolymer 1386g, dissolving is B component; B component slowly adds among the component A, stirs, and is coated with, and is compound with protecting film, cuts promptly to get.
Embodiment 11
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 500g, Lignum Aquilariae Resinatum 300g, Fructus Aurantii 450g, Lignum Santali Albi 100g, Radix Et Rhizoma Rhei 200g, Cortex Magnoliae Officinalis 600g, Moschus 10g, Semen Crotonis Pulveratum 60g, Fructus Jujubae 800g, Rhizoma Chuanxiong 160g are subsequent use;
B. Semen Crotonis Pulveratum, Moschus pulverize separately become fine powder; The Radix Aucklandiae, Lignum Aquilariae Resinatum, Fructus Aurantii, Lignum Santali Albi, Radix Et Rhizoma Rhei, Cortex Magnoliae Officinalis, Fructus Jujubae, Rhizoma Chuanxiong eight flavors are ground into fine powder; With Semen Crotonis Pulveratum, Moschus powder facing-up, mixing sieves; Get above-mentioned hybrid medicine powder 2800g, add glycerol 14710g, Al (OH) 3150g, PAA 2500g mix homogeneously are component A; Get tartaric acid 75g, add distilled water 25000g, acrylate copolymer 1200g, dissolving is B component; B component slowly adds among the component A, stirs, and is coated with, and is compound with protecting film, cuts promptly to get.
Embodiment 12
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 150g, Lignum Aquilariae Resinatum 150g, Fructus Aurantii 150g, Lignum Santali Albi 90g, Radix Et Rhizoma Rhei 90g, Cortex Magnoliae Officinalis 150g, Moschus 4.5g, Semen Crotonis Pulveratum 60g, Fructus Jujubae 500g, Rhizoma Chuanxiong 90g are subsequent use;
B. above ten flavor medicines, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is subsequent use; The Radix Aucklandiae, Lignum Aquilariae Resinatum, Lignum Santali Albi, Fructus Aurantii Immaturus, Cortex Magnoliae Officinalis, Rhizoma Chuanxiong, Rhizoma Coptidis or Radix Scutellariae are pulverized, CO 2Supercritical extraction; Get extract, add an amount of anhydrous alcohol solution, carry out enclose with an amount of β-CD, drying promptly gets clathrate, and is subsequent use; With the medicinal residues ethanol extraction secondary behind the above-mentioned supercritical extraction, merge secondary filtrating, reclaim ethanol and concentrate subsequent use; Get Fructus Jujubae decocte with water secondary, filter; Merging filtrate concentrates, and with above-mentioned alcohol extract condensed cream mixing, drying is ground into fine powder, with clathrate, Semen Crotonis Pulveratum, Moschus mixing, sieves again, and is subsequent use;
Get above-mentioned hybrid medicine powder, add glycerol, Al (OH) 3, the PAA mix homogeneously is component A; Get tartaric acid, add distilled water, acrylate copolymer, dissolving is B component; B component slowly adds among the component A, stirs, and is coated with, and is compound with protecting film, cuts promptly to get.
Embodiment 13
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 150g, Lignum Aquilariae Resinatum 150g, Fructus Aurantii 150g, Lignum Santali Albi 90g, Radix Et Rhizoma Rhei 90g, Cortex Magnoliae Officinalis 150g, Moschus 4.5g, Semen Crotonis Pulveratum 60g, Fructus Jujubae 500g, Rhizoma Chuanxiong 90g are subsequent use;
B. above ten flavor medicines, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is subsequent use; Six-element medicated powder such as Lignum Aquilariae Resinatum, the Radix Aucklandiae, Lignum Santali Albi, Fructus Aurantii Immaturus, Cortex Magnoliae Officinalis, Rhizoma Chuanxiong are broken into coarse powder, add water, soak, and decocting boils distillation, collect volatile oil, and are after β-CD inclusion, subsequent use; Decocting liquid filters, and filtrating concentrates subsequent use, and medicinal residues and Rhizoma Coptidis or Radix Scutellariae coarse powder add alcohol reflux 2 times, filters; Merge secondary filtrating, concentrate, drying, subsequent use; Get Fructus Jujubae, add decocting and boil secondary, filter; Merge secondary filtrating, concentrate, drying, the above-mentioned fine powder that is dried and crushed into, with bag and thing, Semen Crotonis Pulveratum, Moschus mixing, subsequent use;
Get above-mentioned hybrid medicine powder, add glycerol, Al (OH) 3, the PAA mix homogeneously is component A; Get tartaric acid, add distilled water, acrylate copolymer, dissolving is B component; B component slowly adds among the component A, stirs, and is coated with, and is compound with protecting film, cuts promptly to get.
Embodiment 14
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 150g, Lignum Aquilariae Resinatum 150g, Fructus Aurantii 150g, Lignum Santali Albi 90g, Radix Et Rhizoma Rhei 90g, Cortex Magnoliae Officinalis 150g, Moschus 4.5g, Semen Crotonis Pulveratum 60g, Fructus Jujubae 500g, Rhizoma Chuanxiong 90g are subsequent use;
B. get the Radix Aucklandiae, Lignum Aquilariae Resinatum, Lignum Santali Albi, Fructus Aurantii, Cortex Magnoliae Officinalis, Rhizoma Chuanxiong, Radix Et Rhizoma Rhei powder and be broken into coarse powder, add alcohol reflux, filter; Merging filtrate, subsequent use; The concentrating under reduced pressure alcohol extract concentrates subsequent use; Get Fructus Jujubae, add decocting and boil, filter, concentrating under reduced pressure Fructus Jujubae water extract, the simmer down to clear paste, subsequent use; With above-mentioned gained clear paste drying under reduced pressure, getting dry extract is ground into fine powder and Semen Crotonis Pulveratum, Moschus mixing, sieves, subsequent use; Get above-mentioned hybrid medicine powder, add glycerol, Al (OH) 3, the PAA mix homogeneously is component A; Get tartaric acid, add distilled water, acrylate copolymer, dissolving is B component; B component slowly adds among the component A, stirs, and is coated with, and is compound with protecting film, cuts promptly to get.
Embodiment 15
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 150g, Lignum Aquilariae Resinatum 150g, Fructus Aurantii 150g, Lignum Santali Albi 90g, Radix Et Rhizoma Rhei 90g, Cortex Magnoliae Officinalis 150g, Moschus 4.5g, Semen Crotonis Pulveratum 60g, Fructus Jujubae 500g, Rhizoma Chuanxiong 90g are subsequent use;
B. above ten flavors, Semen Crotonis Pulveratum, Moschus pulverize separately become fine powder; All the other eight flavor medicine decocte with water 2 times, each 1 hour, collecting decoction filtered, and is condensed into thick paste; In above-mentioned thick paste, add Semen Crotonis Pulveratum, Moschus powder, mixing, subsequent use; Get said mixture, add glycerol, Al (OH) 3, the PAA mix homogeneously is component A; Get tartaric acid, add distilled water, acrylate copolymer, dissolving is B component; B component slowly adds among the component A, stirs, and is coated with, and is compound with protecting film, cuts promptly to get.
Embodiment 16
A. take off column weight amount proportioning crude drug: the Radix Aucklandiae 150~600g, Lignum Aquilariae Resinatum 150~600g, Fructus Aurantii 150~600g, Lignum Santali Albi 90~360g, Radix Et Rhizoma Rhei 90~360g, Cortex Magnoliae Officinalis 150~600g, Moschus 4.5~18g, Semen Crotonis Pulveratum 60~240g, Fructus Jujubae 500~2000g, Rhizoma Chuanxiong 90~360g are subsequent use;
B. above ten flavor medicines, Semen Crotonis Pulveratum, Moschus pulverize separately become fine powder; The Radix Aucklandiae, Lignum Aquilariae Resinatum, Fructus Aurantii, Lignum Santali Albi, Radix Et Rhizoma Rhei, Cortex Magnoliae Officinalis, Fructus Jujubae, Rhizoma Chuanxiong eight flavors are ground into fine powder; With Semen Crotonis Pulveratum, Moschus powder facing-up, mixing sieves, and is subsequent use;
Get above-mentioned hybrid medicine powder, add glycerol, Al (OH) 3, the PAA mix homogeneously is component A; Get tartaric acid, add distilled water, acrylate copolymer, dissolving is B component; B component slowly adds among the component A, stirs, and is coated with, and is compound with protecting film, cuts promptly to get.
Embodiment 17
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 600g, Lignum Aquilariae Resinatum 600g, Fructus Aurantii 600g, Lignum Santali Albi 360g, Radix Et Rhizoma Rhei 360g, Cortex Magnoliae Officinalis 600g, Moschus 18g, Semen Crotonis Pulveratum 240g, Fructus Jujubae 2000g, Rhizoma Chuanxiong 360g are subsequent use;
B. above ten flavor medicines, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is subsequent use; The Radix Aucklandiae, Lignum Aquilariae Resinatum, Lignum Santali Albi, Fructus Aurantii Immaturus, Cortex Magnoliae Officinalis, Rhizoma Chuanxiong, Rhizoma Coptidis or Radix Scutellariae are pulverized, CO 2Supercritical extraction; Get extract, add an amount of anhydrous alcohol solution, carry out enclose with an amount of β-CD, drying promptly gets clathrate, and is subsequent use; With the medicinal residues ethanol extraction secondary behind the above-mentioned supercritical extraction, merge secondary filtrating, reclaim ethanol and concentrate subsequent use; Get Fructus Jujubae decocte with water secondary, filter; Merging filtrate concentrates, and with above-mentioned alcohol extract condensed cream mixing, drying is ground into fine powder, with clathrate, Semen Crotonis Pulveratum, Moschus mixing, sieves again, and is subsequent use; Get above-mentioned hybrid medicine powder, add glycerol, Al (OH) 3, the PAA mix homogeneously is component A; Get tartaric acid, add distilled water, acrylate copolymer, dissolving is B component; B component slowly adds among the component A, stirs, and is coated with, and is compound with protecting film, cuts promptly to get.
Embodiment 18
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 600g, Lignum Aquilariae Resinatum 600g, Fructus Aurantii 600g, Lignum Santali Albi 360g, Radix Et Rhizoma Rhei 360g, Cortex Magnoliae Officinalis 600g, Moschus 18g, Semen Crotonis Pulveratum 240g, Fructus Jujubae 2000g, Rhizoma Chuanxiong 360g are subsequent use;
B. above ten flavor medicines, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is subsequent use; Six-element medicated powder such as Lignum Aquilariae Resinatum, the Radix Aucklandiae, Lignum Santali Albi, Fructus Aurantii Immaturus, Cortex Magnoliae Officinalis, Rhizoma Chuanxiong are broken into coarse powder, add water, soak, and decocting boils distillation, collect volatile oil, and are after β-CD inclusion, subsequent use; Decocting liquid filters, and filtrating concentrates subsequent use, and medicinal residues and Rhizoma Coptidis or Radix Scutellariae coarse powder add alcohol reflux 2 times, filters; Merge secondary filtrating, concentrate, drying, subsequent use; Get Fructus Jujubae, add decocting and boil secondary, filter; Merge secondary filtrating, concentrate, drying, the above-mentioned fine powder that is dried and crushed into, with bag and thing, Semen Crotonis Pulveratum, Moschus mixing, subsequent use; Get above-mentioned hybrid medicine powder, add glycerol, Al (OH) 3, the PAA mix homogeneously is component A; Get tartaric acid, add distilled water, acrylate copolymer, dissolving is B component; B component slowly adds among the component A, stirs, and is coated with, and is compound with protecting film, cuts promptly to get.
Embodiment 19
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 600g, Lignum Aquilariae Resinatum 600g, Fructus Aurantii 600g, Lignum Santali Albi 360g, Radix Et Rhizoma Rhei 360g, Cortex Magnoliae Officinalis 600g, Moschus 18g, Semen Crotonis Pulveratum 240g, Fructus Jujubae 2000g, Rhizoma Chuanxiong 360g are subsequent use;
B. get the Radix Aucklandiae, Lignum Aquilariae Resinatum, Lignum Santali Albi, Fructus Aurantii, Cortex Magnoliae Officinalis, Rhizoma Chuanxiong, Radix Et Rhizoma Rhei powder and be broken into coarse powder, add alcohol reflux, filter; Merging filtrate, subsequent use; The concentrating under reduced pressure alcohol extract concentrates subsequent use; Get Fructus Jujubae, add decocting and boil, filter, concentrating under reduced pressure Fructus Jujubae water extract, the simmer down to clear paste, subsequent use; With above-mentioned gained clear paste drying under reduced pressure, getting dry extract is ground into fine powder and Semen Crotonis Pulveratum, Moschus mixing, sieves, subsequent use; Get above-mentioned hybrid medicine powder, add glycerol, Al (OH) 3, the PAA mix homogeneously is component A; Get tartaric acid, add distilled water, acrylate copolymer, dissolving is B component; B component slowly adds among the component A, stirs, and is coated with, and is compound with protecting film, cuts promptly to get.
Embodiment 20
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 600g, Lignum Aquilariae Resinatum 600g, Fructus Aurantii 600g, Lignum Santali Albi 360g, Radix Et Rhizoma Rhei 360g, Cortex Magnoliae Officinalis 600g, Moschus 18g, Semen Crotonis Pulveratum 240g, Fructus Jujubae 2000g, Rhizoma Chuanxiong 360g are subsequent use;
B. above ten flavors, Semen Crotonis Pulveratum, Moschus pulverize separately become fine powder; All the other eight flavor medicine decocte with water 3 times, each 3 hours, collecting decoction filtered, and is condensed into thick paste; In above-mentioned thick paste, add Semen Crotonis Pulveratum, Moschus powder, mixing, subsequent use; Get above-mentioned hybrid medicine powder, add glycerol, Al (OH) 3, the PAA mix homogeneously is component A; Get tartaric acid, add distilled water, acrylate copolymer, dissolving is B component; B component slowly adds among the component A, stirs, and is coated with, and is compound with protecting film, cuts promptly to get.
Embodiment 21
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 300g, Lignum Aquilariae Resinatum 300g, Fructus Aurantii 300g, Lignum Santali Albi 180g, Radix Et Rhizoma Rhei 180g, Cortex Magnoliae Officinalis 300g, Moschus 9g, Semen Crotonis Pulveratum 120g, Fructus Jujubae 1000g, Rhizoma Chuanxiong 180g are subsequent use;
B. above ten flavor medicines, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is subsequent use; The Radix Aucklandiae, Lignum Aquilariae Resinatum, Lignum Santali Albi, Fructus Aurantii Immaturus, Cortex Magnoliae Officinalis, Rhizoma Chuanxiong, Rhizoma Coptidis or Radix Scutellariae are pulverized, CO 2Supercritical extraction; Get extract, add an amount of anhydrous alcohol solution, carry out enclose with an amount of β-CD, drying promptly gets clathrate, and is subsequent use; With the medicinal residues ethanol extraction secondary behind the above-mentioned supercritical extraction, merge secondary filtrating, reclaim ethanol and concentrate subsequent use; Get Fructus Jujubae decocte with water secondary, filter; Merging filtrate concentrates, and with above-mentioned alcohol extract condensed cream mixing, drying is ground into fine powder, with clathrate, Semen Crotonis Pulveratum, Moschus mixing, sieves again, and is subsequent use; Get above-mentioned hybrid medicine powder 2869g, add glycerol 13770g, Al (OH) 3183g, PAA 2754g mix homogeneously are component A; Get tartaric acid 92g, add distilled water 27540g, acrylate copolymer 1836g, dissolving is B component; B component slowly adds among the component A, stirs, and is coated with, and is compound with protecting film, cuts promptly to get.
Embodiment 22
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 300g, Lignum Aquilariae Resinatum 300g, Fructus Aurantii 300g, Lignum Santali Albi 180g, Radix Et Rhizoma Rhei 180g, Cortex Magnoliae Officinalis 300g, Moschus 9g, Semen Crotonis Pulveratum 120g, Fructus Jujubae 1000g, Rhizoma Chuanxiong 180g are subsequent use;
B. above ten flavor medicines, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is subsequent use; Six-element medicated powder such as Lignum Aquilariae Resinatum, the Radix Aucklandiae, Lignum Santali Albi, Fructus Aurantii Immaturus, Cortex Magnoliae Officinalis, Rhizoma Chuanxiong are broken into coarse powder, add water, soak, and decocting boils distillation, collect volatile oil, and are after β-CD inclusion, subsequent use; Decocting liquid filters, and filtrating concentrates subsequent use, and medicinal residues and Rhizoma Coptidis or Radix Scutellariae coarse powder add alcohol reflux 2 times, filters; Merge secondary filtrating, concentrate, drying, subsequent use; Get Fructus Jujubae, add decocting and boil secondary, filter; Merge secondary filtrating, concentrate, drying, the above-mentioned fine powder that is dried and crushed into, with bag and thing, Semen Crotonis Pulveratum, Moschus mixing, subsequent use; Get above-mentioned hybrid medicine powder 2869g, add glycerol 13770g, Al (OH) 3183g, PAA 2754g mix homogeneously are component A; Get tartaric acid 92g, add distilled water 27540g, acrylate copolymer 1836g, dissolving is B component; B component slowly adds among the component A, stirs, and is coated with, and is compound with protecting film, cuts promptly to get.
Embodiment 23
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 300g, Lignum Aquilariae Resinatum 300g, Fructus Aurantii 300g, Lignum Santali Albi 180g, Radix Et Rhizoma Rhei 180g, Cortex Magnoliae Officinalis 300g, Moschus 9g, Semen Crotonis Pulveratum 120g, Fructus Jujubae 1000g, Rhizoma Chuanxiong 180g are subsequent use;
B. get the Radix Aucklandiae, Lignum Aquilariae Resinatum, Lignum Santali Albi, Fructus Aurantii, Cortex Magnoliae Officinalis, Rhizoma Chuanxiong, Radix Et Rhizoma Rhei powder and be broken into coarse powder, add alcohol reflux, filter; Merging filtrate, subsequent use; The concentrating under reduced pressure alcohol extract concentrates subsequent use; Get Fructus Jujubae, add decocting and boil, filter, concentrating under reduced pressure Fructus Jujubae water extract, the simmer down to clear paste, subsequent use; With above-mentioned gained clear paste drying under reduced pressure, getting dry extract is ground into fine powder and Semen Crotonis Pulveratum, Moschus mixing, sieves, subsequent use; Get above-mentioned hybrid medicine powder 2869g, add glycerol 13770g, Al (OH) 3183g, PAA 2754g mix homogeneously are component A; Get tartaric acid 92g, add distilled water 27540g, acrylate copolymer 1836g, dissolving is B component; B component slowly adds among the component A, stirs, and is coated with, and is compound with protecting film, cuts promptly to get.
Embodiment 24
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 300g, Lignum Aquilariae Resinatum 300g, Fructus Aurantii 300g, Lignum Santali Albi 180g, Radix Et Rhizoma Rhei 180g, Cortex Magnoliae Officinalis 300g, Moschus 9g, Semen Crotonis Pulveratum 120g, Fructus Jujubae 1000g, Rhizoma Chuanxiong 180g are subsequent use;
B. above ten flavors, Semen Crotonis Pulveratum, Moschus pulverize separately become fine powder; All the other eight flavor medicine decocte with water 2 times, each 2 hours, collecting decoction filtered, and is condensed into thick paste; In above-mentioned thick paste, add Semen Crotonis Pulveratum, Moschus powder, mixing, subsequent use; Get above-mentioned hybrid medicine powder 2869g, add glycerol 13770g, Al (OH) 3183g, PAA 2754g mix homogeneously are component A; Get tartaric acid 92g, add distilled water 27540g, acrylate copolymer 1836g, dissolving is B component; B component slowly adds among the component A, stirs, and is coated with, and is compound with protecting film, cuts promptly to get.
Embodiment 25
A. take off column weight amount proportioning crude drug: the Radix Aucklandiae 150~600g, Lignum Aquilariae Resinatum 150~600g, Fructus Aurantii 150~600g, Lignum Santali Albi 90~360g, Radix Et Rhizoma Rhei 90~360g, Cortex Magnoliae Officinalis 150~600g, Moschus 4.5~18g, Semen Crotonis Pulveratum 60~240g, Fructus Jujubae 500~2000g, Rhizoma Chuanxiong 90~360g are subsequent use;
B. above ten flavor medicines, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is subsequent use; The Radix Aucklandiae, Lignum Aquilariae Resinatum, Lignum Santali Albi, Fructus Aurantii Immaturus, Cortex Magnoliae Officinalis, Rhizoma Chuanxiong, Rhizoma Coptidis or Radix Scutellariae are pulverized, CO 2Supercritical extraction; Get extract, add an amount of anhydrous alcohol solution, carry out enclose with an amount of β-CD, drying promptly gets clathrate, and is subsequent use; With the medicinal residues ethanol extraction secondary behind the above-mentioned supercritical extraction, merge secondary filtrating, reclaim ethanol and concentrate subsequent use; Get Fructus Jujubae decocte with water secondary, filter; Merging filtrate concentrates, and with above-mentioned alcohol extract condensed cream mixing, drying is ground into fine powder, with clathrate, Semen Crotonis Pulveratum, Moschus mixing, sieves again, and is subsequent use;
Get above-mentioned hybrid medicine powder, add glycerol, Al (OH) 3, the PAA mix homogeneously is component A; Get tartaric acid, add distilled water, acrylate copolymer, dissolving is B component; B component slowly adds among the component A, stirs, and is coated with, and is compound with protecting film, cuts promptly to get.
Embodiment 26
A. take off column weight amount proportioning crude drug: the Radix Aucklandiae 150~600g, Lignum Aquilariae Resinatum 150~600g, Fructus Aurantii 150~600g, Lignum Santali Albi 90~360g, Radix Et Rhizoma Rhei 90~360g, Cortex Magnoliae Officinalis 150~600g, Moschus 4.5~18g, Semen Crotonis Pulveratum 60~240g, Fructus Jujubae 500~2000g, Rhizoma Chuanxiong 90~360g are subsequent use;
B. above ten flavor medicines, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is subsequent use; Six-element medicated powder such as Lignum Aquilariae Resinatum, the Radix Aucklandiae, Lignum Santali Albi, Fructus Aurantii Immaturus, Cortex Magnoliae Officinalis, Rhizoma Chuanxiong are broken into coarse powder, add water, soak, and decocting boils distillation, collect volatile oil, and are after β-CD inclusion, subsequent use; Decocting liquid filters, and filtrating concentrates subsequent use, and medicinal residues and Rhizoma Coptidis or Radix Scutellariae coarse powder add alcohol reflux 2 times, filters; Merge secondary filtrating, concentrate, drying, subsequent use; Get Fructus Jujubae, add decocting and boil secondary, filter; Merge secondary filtrating, concentrate, drying, the above-mentioned fine powder that is dried and crushed into, with bag and thing, Semen Crotonis Pulveratum, Moschus mixing, subsequent use;
Get above-mentioned hybrid medicine powder, add glycerol, Al (OH) 3, the PAA mix homogeneously is component A; Get tartaric acid, add distilled water, acrylate copolymer, dissolving is B component; B component slowly adds among the component A, stirs, and is coated with, and is compound with protecting film, cuts promptly to get.
Embodiment 27
A. take off column weight amount proportioning crude drug: the Radix Aucklandiae 150~600g, Lignum Aquilariae Resinatum 150~600g, Fructus Aurantii 150~600g, Lignum Santali Albi 90~360g, Radix Et Rhizoma Rhei 90~360g, Cortex Magnoliae Officinalis 150~600g, Moschus 4.5~18g, Semen Crotonis Pulveratum 60~240g, Fructus Jujubae 500~2000g, Rhizoma Chuanxiong 90~360g are subsequent use;
B. get the Radix Aucklandiae, Lignum Aquilariae Resinatum, Lignum Santali Albi, Fructus Aurantii, Cortex Magnoliae Officinalis, Rhizoma Chuanxiong, Radix Et Rhizoma Rhei powder and be broken into coarse powder, add alcohol reflux, filter; Merging filtrate, subsequent use; The concentrating under reduced pressure alcohol extract concentrates subsequent use; Get Fructus Jujubae, add decocting and boil, filter, concentrating under reduced pressure Fructus Jujubae water extract, the simmer down to clear paste, subsequent use; With above-mentioned gained clear paste drying under reduced pressure, getting dry extract is ground into fine powder and Semen Crotonis Pulveratum, Moschus mixing, sieves, subsequent use;
Get above-mentioned hybrid medicine powder, add glycerol, Al (OH) 3, the PAA mix homogeneously is component A; Get tartaric acid, add distilled water, acrylate copolymer, dissolving is B component; B component slowly adds among the component A, stirs, and is coated with, and is compound with protecting film, cuts promptly to get.
Embodiment 28
A. take off column weight amount proportioning crude drug: the Radix Aucklandiae 150~600g, Lignum Aquilariae Resinatum 150~600g, Fructus Aurantii 150~600g, Lignum Santali Albi 90~360g, Radix Et Rhizoma Rhei 90~360g, Cortex Magnoliae Officinalis 150~600g, Moschus 4.5~18g, Semen Crotonis Pulveratum 60~240g, Fructus Jujubae 500~2000g, Rhizoma Chuanxiong 90~360g are subsequent use;
B. above ten flavors, Semen Crotonis Pulveratum, Moschus pulverize separately become fine powder; All the other eight flavor medicine decocte with water 1~3 time, each 1~3 hour, collecting decoction filtered, and is condensed into thick paste; In above-mentioned thick paste, add Semen Crotonis Pulveratum, Moschus powder, mixing, subsequent use;
Get above-mentioned hybrid medicine powder, add glycerol, Al (OH) 3, the PAA mix homogeneously is component A; Get tartaric acid, add distilled water, acrylate copolymer, dissolving is B component; B component slowly adds among the component A, stirs, and is coated with, and is compound with protecting film, cuts promptly to get.

Claims (3)

1. method for preparing of treating the Chinese medicine patcher of gastrointestinal disease is characterized in that step is following:
A. take off column weight amount proportioning crude drug: the Radix Aucklandiae 150~600g, Lignum Aquilariae Resinatum 150~600g, Fructus Aurantii 150~600g, Lignum Santali Albi 90~360g, Radix Et Rhizoma Rhei 90~360g, Cortex Magnoliae Officinalis 150~600g, Moschus 4.5~18g, Semen Crotonis Pulveratum 60~240g, Fructus Jujubae 500~2000g, Rhizoma Chuanxiong 90~360g are subsequent use;
B. above ten flavor medicines, Semen Crotonis Pulveratum, Moschus pulverize separately become fine powder; The Radix Aucklandiae, Lignum Aquilariae Resinatum, Fructus Aurantii, Lignum Santali Albi, Radix Et Rhizoma Rhei, Cortex Magnoliae Officinalis, Fructus Jujubae, Rhizoma Chuanxiong eight flavors are ground into fine powder; With Semen Crotonis Pulveratum, Moschus powder facing-up, mixing sieves, and is subsequent use;
Perhaps above ten flavor medicines, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is subsequent use; The Radix Aucklandiae, Lignum Aquilariae Resinatum, Lignum Santali Albi, Fructus Aurantii, Cortex Magnoliae Officinalis, Rhizoma Chuanxiong, Radix Et Rhizoma Rhei are pulverized CO 2Supercritical extraction; Get extract, add an amount of anhydrous alcohol solution, carry out enclose with an amount of β-CD, drying promptly gets clathrate, and is subsequent use; With the medicinal residues ethanol extraction secondary behind the above-mentioned supercritical extraction, merge secondary filtrating, reclaim ethanol and concentrate subsequent use; Get Fructus Jujubae decocte with water secondary, filter; Merging filtrate concentrates, and with above-mentioned alcohol extract condensed cream mixing, drying is ground into fine powder, with clathrate, Semen Crotonis Pulveratum, Moschus mixing, sieves again, and is subsequent use;
Perhaps above ten flavor medicines, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is subsequent use; Six-element medicated powder such as Lignum Aquilariae Resinatum, the Radix Aucklandiae, Lignum Santali Albi, Fructus Aurantii, Cortex Magnoliae Officinalis, Rhizoma Chuanxiong are broken into coarse powder, add water, soak, and decocting boils distillation, collect volatile oil, and are behind β-CDBao He, subsequent use; Decocting liquid filters, and filtrating concentrates subsequent use, and medicinal residues and Radix Et Rhizoma Rhei coarse powder add alcohol reflux 2 times, filters; Merge secondary filtrating, concentrate, drying, subsequent use; Get Fructus Jujubae, add decocting and boil secondary, filter; Merge secondary filtrating, concentrate, drying, the above-mentioned fine powder that is dried and crushed into, with clathrate, Semen Crotonis Pulveratum, Moschus mixing, subsequent use;
Perhaps get the Radix Aucklandiae, Lignum Aquilariae Resinatum, Lignum Santali Albi, Fructus Aurantii, Cortex Magnoliae Officinalis, Rhizoma Chuanxiong, Radix Et Rhizoma Rhei powder and be broken into coarse powder, add alcohol reflux, filter; Merging filtrate, subsequent use; The concentrating under reduced pressure alcohol extract concentrates subsequent use; Get Fructus Jujubae, add decocting and boil, filter, concentrating under reduced pressure Fructus Jujubae water extract, the simmer down to clear paste, subsequent use; With above-mentioned gained clear paste drying under reduced pressure, getting dry extract is ground into fine powder and Semen Crotonis Pulveratum, Moschus mixing, sieves, subsequent use;
Perhaps above ten flavors, Semen Crotonis Pulveratum, Moschus pulverize separately become fine powder; All the other eight flavor medicine decocte with water 1~3 time, each 1~3 hour, collecting decoction filtered, and is condensed into thick paste; In above-mentioned thick paste, add Semen Crotonis Pulveratum, Moschus powder, mixing, subsequent use;
Get above-mentioned arbitrary hybrid medicine powder, add glycerol, Al (OH) 3, the PAA mix homogeneously is component A; Get tartaric acid, add distilled water, acrylate copolymer, dissolving is B component; B component slowly adds among the component A, stirs, and is coated with, and is compound with protecting film, cuts promptly to get.
2. the method for preparing of the Chinese medicine patcher of the said treatment gastrointestinal disease of claim 1 is characterized in that step is following:
A. take off column weight amount proportioning crude drug: the Radix Aucklandiae 250~400g, Lignum Aquilariae Resinatum 250~400g, Fructus Aurantii 250~400g, Lignum Santali Albi 150~250g, Radix Et Rhizoma Rhei 150~250g, Cortex Magnoliae Officinalis 250~400g, Moschus 6~12g, Semen Crotonis Pulveratum 100~150g, Fructus Jujubae 800~1200g, Rhizoma Chuanxiong 150~250g are subsequent use;
B. above ten flavor medicines, Semen Crotonis Pulveratum, Moschus pulverize separately become fine powder; The Radix Aucklandiae, Lignum Aquilariae Resinatum, Fructus Aurantii, Lignum Santali Albi, Radix Et Rhizoma Rhei, Cortex Magnoliae Officinalis, Fructus Jujubae, Rhizoma Chuanxiong eight flavors are ground into fine powder; With Semen Crotonis Pulveratum, Moschus powder facing-up, mixing sieves, and is subsequent use;
Perhaps above ten flavor medicines, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is subsequent use; The Radix Aucklandiae, Lignum Aquilariae Resinatum, Lignum Santali Albi, Fructus Aurantii, Cortex Magnoliae Officinalis, Rhizoma Chuanxiong, Radix Et Rhizoma Rhei are pulverized CO 2Supercritical extraction; Get extract, add an amount of anhydrous alcohol solution, carry out enclose with an amount of β-CD, drying promptly gets clathrate, and is subsequent use; With the medicinal residues ethanol extraction secondary behind the above-mentioned supercritical extraction, merge secondary filtrating, reclaim ethanol and concentrate subsequent use; Get Fructus Jujubae decocte with water secondary, filter; Merging filtrate concentrates, and with above-mentioned alcohol extract condensed cream mixing, drying is ground into fine powder, with clathrate, Semen Crotonis Pulveratum, Moschus mixing, sieves again, and is subsequent use;
Perhaps above ten flavor medicines, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is subsequent use; Six-element medicated powder such as Lignum Aquilariae Resinatum, the Radix Aucklandiae, Lignum Santali Albi, Fructus Aurantii, Cortex Magnoliae Officinalis, Rhizoma Chuanxiong are broken into coarse powder, add water, soak, and decocting boils distillation, collect volatile oil, and are behind β-CDBao He, subsequent use; Decocting liquid filters, and filtrating concentrates subsequent use, and medicinal residues and Radix Et Rhizoma Rhei coarse powder add alcohol reflux 2 times, filters; Merge secondary filtrating, concentrate, drying, subsequent use; Get Fructus Jujubae, add decocting and boil secondary, filter; Merge secondary filtrating, concentrate, drying, the above-mentioned fine powder that is dried and crushed into, with clathrate, Semen Crotonis Pulveratum, Moschus mixing, subsequent use;
Perhaps get the Radix Aucklandiae, Lignum Aquilariae Resinatum, Lignum Santali Albi, Fructus Aurantii, Cortex Magnoliae Officinalis, Rhizoma Chuanxiong, Radix Et Rhizoma Rhei powder and be broken into coarse powder, add alcohol reflux, filter; Merging filtrate, subsequent use; The concentrating under reduced pressure alcohol extract concentrates subsequent use; Get Fructus Jujubae, add decocting and boil, filter, concentrating under reduced pressure Fructus Jujubae water extract, the simmer down to clear paste, subsequent use; With above-mentioned gained clear paste drying under reduced pressure, getting dry extract is ground into fine powder and Semen Crotonis Pulveratum, Moschus mixing, sieves, subsequent use;
Perhaps above ten flavors, Semen Crotonis Pulveratum, Moschus pulverize separately become fine powder; All the other eight flavor medicine decocte with water 1~3 time, each 1~3 hour, collecting decoction filtered, and is condensed into thick paste; In above-mentioned thick paste, add Semen Crotonis Pulveratum, Moschus powder, mixing, subsequent use;
Get above-mentioned arbitrary hybrid medicine powder, add glycerol, Al (OH) 3, the PAA mix homogeneously is component A; Get tartaric acid, add distilled water, acrylate copolymer, dissolving is B component; B component slowly adds among the component A, stirs, and is coated with, and is compound with protecting film, cuts promptly to get.
3. the method for preparing of the Chinese medicine patcher of the said treatment gastrointestinal disease of claim 2 is characterized in that comprising the steps:
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 300g, Lignum Aquilariae Resinatum 300g, Fructus Aurantii 300g, Lignum Santali Albi 180g, Radix Et Rhizoma Rhei 180g, Cortex Magnoliae Officinalis 300g, Moschus 9g, Semen Crotonis Pulveratum 120g, Fructus Jujubae 1000g, Rhizoma Chuanxiong 180g are subsequent use;
B. above ten flavor medicines, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is subsequent use; The Radix Aucklandiae, Lignum Aquilariae Resinatum, Lignum Santali Albi, Fructus Aurantii, Cortex Magnoliae Officinalis, Rhizoma Chuanxiong, Radix Et Rhizoma Rhei are pulverized CO 2Supercritical extraction; Get extract, add an amount of anhydrous alcohol solution, carry out enclose with an amount of β-CD, drying promptly gets clathrate, and is subsequent use; With the medicinal residues ethanol extraction secondary behind the above-mentioned supercritical extraction, merge secondary filtrating, reclaim ethanol and concentrate subsequent use; Get Fructus Jujubae decocte with water secondary, filter; Merging filtrate concentrates, and with above-mentioned alcohol extract condensed cream mixing, drying is ground into fine powder, with clathrate, Semen Crotonis Pulveratum, Moschus mixing, sieves again, and is subsequent use;
Perhaps above ten flavor medicines, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is subsequent use; Six-element medicated powder such as Lignum Aquilariae Resinatum, the Radix Aucklandiae, Lignum Santali Albi, Fructus Aurantii, Cortex Magnoliae Officinalis, Rhizoma Chuanxiong are broken into coarse powder, add water, soak, and decocting boils distillation, collect volatile oil, and are after β-CD inclusion, subsequent use; Decocting liquid filters, and filtrating concentrates subsequent use, and medicinal residues and Radix Et Rhizoma Rhei coarse powder add alcohol reflux 2 times, filters; Merge secondary filtrating, concentrate, drying, subsequent use; Get Fructus Jujubae, add decocting and boil secondary, filter; Merge secondary filtrating, concentrate, drying, the above-mentioned fine powder that is dried and crushed into, with bag and thing, Semen Crotonis Pulveratum, Moschus mixing, subsequent use;
Perhaps get the Radix Aucklandiae, Lignum Aquilariae Resinatum, Lignum Santali Albi, Fructus Aurantii, Cortex Magnoliae Officinalis, Rhizoma Chuanxiong, Radix Et Rhizoma Rhei powder and be broken into coarse powder, add alcohol reflux, filter; Merging filtrate, subsequent use; The concentrating under reduced pressure alcohol extract concentrates subsequent use; Get Fructus Jujubae, add decocting and boil, filter, concentrating under reduced pressure Fructus Jujubae water extract, the simmer down to clear paste, subsequent use; With above-mentioned gained clear paste drying under reduced pressure, getting dry extract is ground into fine powder and Semen Crotonis Pulveratum, Moschus mixing, sieves, subsequent use;
Perhaps above ten flavors, Semen Crotonis Pulveratum, Moschus pulverize separately become fine powder; All the other eight flavor medicine decocte with water 1~3 time, each 1~3 hour, collecting decoction filtered, and is condensed into thick paste; In above-mentioned thick paste, add Semen Crotonis Pulveratum, Moschus powder, mixing, subsequent use;
Get above-mentioned arbitrary hybrid medicine powder 2869g, add glycerol 13770g, Al (OH) 3183g, PAA 2754g mix homogeneously are component A; Get tartaric acid 92g, add distilled water 27540g, acrylate copolymer 1836g, dissolving is B component; B component slowly adds among the component A, stirs, and is coated with, and is compound with protecting film, cuts promptly to get.
CN2008101544159A 2008-12-24 2008-12-24 Traditional Chinese medicine cataplasma for treating gastrointestinal diseases and preparation method thereof Active CN101757282B (en)

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