CN101757286B - Traditional Chinese medicine gel for treating gastrointestinal diseases and preparation method thereof - Google Patents

Traditional Chinese medicine gel for treating gastrointestinal diseases and preparation method thereof Download PDF

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Publication number
CN101757286B
CN101757286B CN200810154420XA CN200810154420A CN101757286B CN 101757286 B CN101757286 B CN 101757286B CN 200810154420X A CN200810154420X A CN 200810154420XA CN 200810154420 A CN200810154420 A CN 200810154420A CN 101757286 B CN101757286 B CN 101757286B
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subsequent use
moschus
powder
semen crotonis
crotonis pulveratum
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CN101757286A (en
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陈坚
王磊
袁学海
王伟
杨瑾
王春晨
郝忻
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Lerentang Pharmaceutical Factory Of Jinyao Darentang Group Co ltd
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Lerentang Pharmaceutical Factory of Tianjin Zhongxin Pharmaceutical Group Co Ltd
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    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
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Abstract

The invention relates to a traditional Chinese medicine gel for treating gastrointestinal diseases and a preparation method thereof. The traditional Chinese medicine gel is a patch prepared from tens of traditional Chinese herbs of costustoot, agilawood, fructus aurantii, sanders, rheum officinale, mangnolia officinalis, muak, defatted croton seed powder, date and ligusticum wallichii. The traditional Chinese medicine gel is mainly used for treating diseases of acute diarrhea, irritable bowel syndrome and the like in clinic.

Description

A kind of Chinese medicine gel of treating gastrointestinal disease and preparation method thereof
Technical field
The present invention relates to field of medicaments, particularly relate to a kind of Chinese medicine gel of treating gastrointestinal disease and preparation method thereof.
Background technology
Diarrhoea can be divided into infectious and non-infectious two types.Infectious diarrhea is divided into bacterial infection and viral infection again; Noninfectious diarrhea then can be caused by the change of improper diet, food anaphylaxis, rule of life, abrupt change of climate even multiple reason such as nervous.Motherland's medical science thinks to have loose bowels and is meant that defecation frequency increases, feces is rare clearly, even like water sample.The major lesions of having loose bowels is taste and intestine and small intestine.Its pathogenesis has being invaded by exogenous pathogen, injury due to diet, seven emotions discord, damp internal resistance and internal organs weakness etc.The clinical findings damp is caused a disease has cold-damp and damp and hot branch.Spleen and stomach function expands, and to hinder be to be caused by multiple factor, has exopathogen influence, taste weakness itself, incoordination between the liver and spleen and kidney intestinal deficiency etc. all can cause spleen and stomach function not normal and have loose bowels.Survey data shows that diarrhoea sickness rate in urban population reaches 0.4 time/people, and the rural population sickness rate reaches 0.5 time/people.Though diarrhoea is minor illness, pathogenic factor also is diversified, and changes with epoch, environment.We can say that the diarrhoea of today and the diarrhoea before 20 years see that from pathogeny the change of essence has been arranged.Along with development of times, people's living standard attains the well-off standard basically, and sanitary condition is improved greatly; Diarrhoea ratio by bacterial infection causes is fewer and feweri, on the contrary, because rhythm of life is accelerated; Struggle for existence is fierce, and the functional diarrhea ratio that pressure causes greatly obviously rises.A research shows that the diarrhoeal diseases people of China about 30% needs antibiosis usually to treat, and 70% does not need should not use antibiotic therapy yet.Consumer also more and more notices the untoward reaction of products such as berberine, norfloxacin, and the harm that abuse of antibiotics brought.Diarrhoea market is except low side antibiotic products such as berberine, norfloxacin; Some non-antibiotic products have also been introduced in recent years; Such as dioctahedral smectite, Birid Triple Viable etc.; But be positioned at high-end consumer groups, for most of consumer groups, its price positioning does not conform to the consumption location of such minor illness of suffering from diarrhoea with consumer.Analysis expert thinks, urban market diarrhoea mainly be with viral be main, be main in the rural area with bacterial infection, if according to the principle of the market segments, at present a lot of products all are difficult to cover the whole market.For alteration of intestinal flora person, available little ecological active bacteria formulation provides probiotics, improves intestinal environment, improves intestinal absorption, kinestate.As: bifidobacteria viable bacteria preparation (the happy capsule of beautiful pearl intestinal), Birid Triple Viable capsule, bacillus cicheniformis (whole intestinal rubber capsule); The intestinal mucosa protective agent: two eight body Montmorillonitums (dioctahedral smectite), the protection intestinal mucosa can suppress fixedly mycin, promotes the intestinal mucosal lesion reparation; Contain the creosote component preparation: the excessive secretion that can suppress intestinal juice.
At present on the market gastrointestinal disease treating pill is mainly used in treatment diarrhoea, enteritis, and bacillary dysentery, distension and fullness in the abdomen, stomachache, the food stagnation infantile dyspepsia, its pharmacological action is higher than like product: diarrhea, antibiotic, antiviral, four kinds of functions of adjusting gastrointestinal function are also deposited.But contain Cinnabaris in its prescription; Its effect is a tranquillizing the mind by relieving convulsion; But contain hydrargyrum in the Cinnabaris; Hydrargyrum is very big to the harm of human body, and it is the process of a subtle lasting absorption, and human body contacts hydrargyrum for a long time can cause chronic poisoning: nerve, digestion, hormonal system and kidney to the people produce harm; Neurasthenic crowd may cause symptoms such as headache, dizziness, insomnia, hypomnesis, malaise; And anemia of pregnant woman and the women of age of sucking contact hydrargyrum for a long time, also possibly endanger fetus and baby's health.Mercurous in addition medicine has received certain restriction when exporting other countries, require mercury content to require then strict more for some European countries less than 0.5ppm like Singapore.Secondly, pill remains in certain shortcoming, if any taking dose big, child administration difficulty especially; Production procedure is long, and opportunities for contamination is many, and misoperation influences disintegrate and curative effect.Patch is as a kind of common dosage form, its suitable each age group and special population.
Summary of the invention
The purpose of this invention is to provide a kind of Chinese medicine gel of treating gastrointestinal disease.
Another object of the present invention provides a kind of method for preparing of treating the Chinese medicine gel of gastrointestinal disease.
The Chinese medicine gel that the present invention treats gastrointestinal disease is to be processed by the Radix Aucklandiae, Lignum Aquilariae Resinatum, Fructus Aurantii, Lignum Santali Albi, Radix Et Rhizoma Rhei, Cortex Magnoliae Officinalis, Moschus, Semen Crotonis Pulveratum, Fructus Jujubae, Rhizoma Chuanxiong ten flavor flavour of a drug.Pharmaceutical composition of the present invention has been selected Lignum Aquilariae Resinatum, Lignum Santali Albi, Radix Aucklandiae removing dampness by means of aromatics, regulating QI to relieve pain, non-return, the invigorating the spleen to arrest diarrhea of sending down the abnormal ascending QI for use to the pathogeny of having loose bowels.Wherein Lignum Aquilariae Resinatum sending down the abnormal ascending QI, Lignum Santali Albi rise gas, the Radix Aucklandiae is longer than the stagnant gas of capable the intestines and stomach.Three medicine mutual reinforcements between are for using stasis, promoting the circulation of QI to relieve pain, reason spleen antidiarrheal, removing dampness by means of aromatics, the expelling cold to relieve vomiting of function of spleen and stomach regulating intestine and small intestine effectively.Be aided with Fructus Aurantii, Cortex Magnoliae Officinalis, the painful abdominal mass removing dampness that disappears of regulating the flow of vital energy is loose long-pendingly, and intestinal stasis relieving helps digestion, and is equipped with gas medicine in the Rhizoma Chuanxiong fortune blood with blood-activating and qi-promoting.The six hollow viscera must keep its unobstructed, also the disease of having loose bowels itself also is a kind of function of human body self-protection.Invade as pathogenic factor, blindness antidiarrheal was closed door and is stayed Kou Zhiyu when dyspepsia was stagnated, so we have selected for use Radix Et Rhizoma Rhei, Semen Crotonis Pulveratum with stasis removing; Radix Et Rhizoma Rhei bitter cold, Semen Crotonis Pulveratum are hot; Two medicine fit applications have promptly been avoided the too numbness of cold and heat, have strengthened stasis removing again and have removed evil malicious the stagnating of delaying at enteral.This treating incontinent symptoms (pseudomorph) by dredging method reach the purpose that toxin expelling antidiarrheal is not stayed poison from method of treatment.This also is our most important character.Be equipped with the Fructus Jujubae spleen reinforcing, relax the property of medicine.All medicines share, with reach eliminating turbid pathogen with aromatics, regulating QI to relieve pain, the effect of the intestinal stasis relieving that is good for the stomach, with the treatment turbid damp obstructing in middle-JIAO, the diarrhoea due to dyspepsia is not changed, poor appetite, feel sick, diseases such as vomiting, abdominal distention, stomachache, dyspepsia, enteritis, bacillary dysentery, viral diarrhea.
The present invention treats the Chinese medicine gel of gastrointestinal disease, can adopt following method to prepare active component for crude drug: like one or several Combined application preparations in extraction, water extraction, decoction and alcohol sedimentation technique, infusion process, percolation, reflux extraction, continuous backflow extraction method, the macroreticular resin absorbing method.But in order to make each crude drug of this medicine bring into play drug effect better, the present invention preferably adopts following technology to extract active component to raw material, and processes the Chinese medicine gel that the present invention treats gastrointestinal disease, but this can not limit protection scope of the present invention.
The present invention treats the Chinese medicine gel of gastrointestinal disease, and employing is prepared as follows method and processes:
A. take off column weight amount proportioning crude drug: the Radix Aucklandiae 150～600g, Lignum Aquilariae Resinatum 150～600g, Fructus Aurantii 150～600g, Lignum Santali Albi 90～360g, Radix Et Rhizoma Rhei 90～360g, Cortex Magnoliae Officinalis 150～600g, Moschus 4.5～18g, Semen Crotonis Pulveratum 60～240g, Fructus Jujubae 500～2000g, Rhizoma Chuanxiong 90～360g are subsequent use;
B. get Semen Crotonis Pulveratum, the Moschus pulverize separately becomes fine powder; The Radix Aucklandiae, Lignum Aquilariae Resinatum, Fructus Aurantii, Lignum Santali Albi, Radix Et Rhizoma Rhei, Cortex Magnoliae Officinalis, Fructus Jujubae, Rhizoma Chuanxiong eight flavors are ground into fine powder; With Semen Crotonis Pulveratum, Moschus powder facing-up, mixing sieves, and is subsequent use;
Perhaps above ten flavor medicines, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is subsequent use; The Radix Aucklandiae, Lignum Aquilariae Resinatum, Lignum Santali Albi, Fructus Aurantii Immaturus, Cortex Magnoliae Officinalis, Rhizoma Chuanxiong, Rhizoma Coptidis or Radix Scutellariae are pulverized, CO 2Supercritical extraction; Get extract, add an amount of anhydrous alcohol solution, carry out enclose with an amount of β-CD, drying promptly gets clathrate, and is subsequent use; With the medicinal residues ethanol extraction secondary behind the above-mentioned supercritical extraction, merge secondary filtrating, reclaim ethanol and concentrate subsequent use; Get Fructus Jujubae decocte with water secondary, filter; Merging filtrate concentrates, and with above-mentioned alcohol extract condensed cream mixing, drying is ground into fine powder, with clathrate, Semen Crotonis Pulveratum, Moschus mixing, sieves again, and is subsequent use;
Perhaps above ten flavor medicines, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is subsequent use; Six-element medicated powder such as Lignum Aquilariae Resinatum, the Radix Aucklandiae, Lignum Santali Albi, Fructus Aurantii Immaturus, Cortex Magnoliae Officinalis, Rhizoma Chuanxiong are broken into coarse powder, add water, soak, and decocting boils distillation, collect volatile oil, and are after β-CD inclusion, subsequent use; Decocting liquid filters, and filtrating concentrates subsequent use, and medicinal residues and Rhizoma Coptidis or Radix Scutellariae coarse powder add alcohol reflux 2 times, filters; Merge secondary filtrating, concentrate, drying, subsequent use; Get Fructus Jujubae, add decocting and boil secondary, filter; Merge secondary filtrating, concentrate, drying, the above-mentioned fine powder that is dried and crushed into, with bag and thing, Semen Crotonis Pulveratum, Moschus mixing, subsequent use;
Perhaps get the Radix Aucklandiae, Lignum Aquilariae Resinatum, Lignum Santali Albi, Fructus Aurantii, Cortex Magnoliae Officinalis, Rhizoma Chuanxiong, Radix Et Rhizoma Rhei powder and be broken into coarse powder, add alcohol reflux, filter; Merging filtrate, subsequent use; The concentrating under reduced pressure alcohol extract concentrates subsequent use; Get Fructus Jujubae, add decocting and boil, filter, concentrating under reduced pressure Fructus Jujubae water extract, the simmer down to clear paste, subsequent use; With above-mentioned gained clear paste drying under reduced pressure, getting dry extract is ground into fine powder and Semen Crotonis Pulveratum, Moschus mixing, sieves, subsequent use;
Perhaps above ten flavors, Semen Crotonis Pulveratum, Moschus pulverize separately become fine powder; All the other eight flavor medicine decocte with water 1～3 time, each 1～3 hour, collecting decoction filtered, and is condensed into thick paste; In above-mentioned thick paste, add Semen Crotonis Pulveratum, Moschus powder, mixing, subsequent use;
Get an amount of carbomer, add water and stir, NaOH regulates pH value, adds said mixture and grinds evenly, promptly gets.
The present invention preferably treats the Chinese medicine gel of gastrointestinal disease, and employing is prepared as follows method and processes:
A. take off column weight amount proportioning crude drug: the Radix Aucklandiae 250～400g, Lignum Aquilariae Resinatum 250～400g, Fructus Aurantii 250～400g, Lignum Santali Albi 150～250g, Radix Et Rhizoma Rhei 150～250g, Cortex Magnoliae Officinalis 250～400g, Moschus 6～12g, Semen Crotonis Pulveratum 100～150g, Fructus Jujubae 800～1200g, Rhizoma Chuanxiong 150～250g are subsequent use;
B. above ten flavor medicines, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is subsequent use; Lignum Aquilariae Resinatum, the Radix Aucklandiae, Lignum Santali Albi, Fructus Aurantii Immaturus, Cortex Magnoliae Officinalis, Rhizoma Chuanxiong, Rhizoma Coptidis or Radix Scutellariae powder are broken into 40-80 purpose powder, CO 2Supercritical extraction, extracting pressure 5-40MPa, temperature 35-60 ℃, CO 2Flow velocity 20-35L/h, extraction 2-5h; Get extract, add an amount of anhydrous alcohol solution,, adopt polishing to carry out enclose,, promptly get clathrate in 40 ℃ of vacuum dryings with an amount of β-CD, subsequent use; Medicinal residues behind the above-mentioned supercritical extraction are added 60% ethanol extraction secondary, merge secondary filtrating, relative density is that 1.25-1.30 is subsequent use when reclaiming ethanol to 60 ℃; Get Fructus Jujubae decocte with water secondary, each 2h filters; Merging filtrate, relative density 1.25-1.30 when being concentrated into 60 ℃, with above-mentioned alcohol extract condensed cream mixing, drying is ground into fine powder, again with clathrate, Semen Crotonis Pulveratum, Moschus mixing, crosses 80 mesh sieves, and is subsequent use;
Perhaps above ten flavor medicines, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is subsequent use; Six-element medicated powder such as Lignum Aquilariae Resinatum, the Radix Aucklandiae, Lignum Santali Albi, Fructus Aurantii Immaturus, Cortex Magnoliae Officinalis, Rhizoma Chuanxiong are broken into coarse powder, add 16 times of water gagings, soak 4 hours, and decocting boils distillation 8h altogether, collects volatile oil, and is after β-CD inclusion, subsequent use; Decocting liquid filters, and relative density 1.25-1.30 was subsequent use when filtrating was concentrated into 60 ℃, and medicinal residues and Rhizoma Coptidis or Radix Scutellariae coarse powder add 70% alcohol reflux 2 times, for the first time 2h; 1h filters for the second time; Merge secondary filtrating, relative density 1.20-1.25 when being concentrated into 60 ℃, drying, subsequent use; Get Fructus Jujubae, add decocting and boil secondary, each 2h filters; Merge secondary filtrating, relative density 1.28-1.32 when being concentrated into 60 ℃, drying, with the above-mentioned fine powder that is dried and crushed into,, subsequent use with bag and thing, Semen Crotonis Pulveratum, Moschus mixing;
Perhaps get the Radix Aucklandiae, Lignum Aquilariae Resinatum, Lignum Santali Albi, Fructus Aurantii, Cortex Magnoliae Officinalis, Rhizoma Chuanxiong, Radix Et Rhizoma Rhei powder and be broken into coarse powder, add 80% alcohol reflux 2 times, 8 times of amounts of alcohol adding amount for the first time, backflow 2h; 6 times of amounts of the alcohol adding amount second time, backflow 1h filters; Merge secondary filtrating, subsequent use; Relative density 1.25-1.30 is subsequent use when concentrating under reduced pressure alcohol extract, 60 ℃ of 60-65 ℃ of simmer down tos; Get Fructus Jujubae, add decocting and boil secondary, add 10 times of amounts of water, backflow 2h for the first time; For the second time add 8 times of amounts of water, backflow 1h filters, and merges secondary filtrating, and is subsequent use; Concentrating under reduced pressure Fructus Jujubae water extract, the clear paste of relative density 1.28-1.32 is subsequent use when 60 ℃ of 80-85 ℃ of following simmer down tos; With above-mentioned gained clear paste drying under reduced pressure, getting dry extract is ground into fine powder and Semen Crotonis Pulveratum, Moschus mixing, crosses 80 mesh sieves, subsequent use;
Perhaps above ten flavors, Semen Crotonis Pulveratum, Moschus pulverize separately become fine powder; Eight flavor medicine decocte with water such as all the other Radix Aucklandiae, Lignum Aquilariae Resinatum 2 times, each 2 hours, collecting decoction filtered, and is condensed into thick paste, in above-mentioned thick paste, adds Semen Crotonis Pulveratum, Moschus powder, and mixing is subsequent use;
Perhaps above crude drug, Semen Crotonis Pulveratum, Moschus pulverize separately become fine powder; All the other crude drug are ground into fine powder, and with Semen Crotonis Pulveratum, Moschus powder facing-up, mixing sieves, and is subsequent use;
Get carbomer 80～200g, add water 5000～20000g and stir, NaOH regulates pH value, adds said mixture 1000～3500g, grinds evenly, promptly gets.
The Chinese medicine gel of the further preferred treatment gastrointestinal disease of the present invention, employing is prepared as follows method and processes:
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 300g, Lignum Aquilariae Resinatum 300g, Fructus Aurantii 300g, Lignum Santali Albi 180g, Radix Et Rhizoma Rhei 180g, Cortex Magnoliae Officinalis 300g, Moschus 9g, Semen Crotonis Pulveratum 120g, Fructus Jujubae 1000g, Rhizoma Chuanxiong 180g are subsequent use;
B. above ten flavor medicines, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is subsequent use; Lignum Aquilariae Resinatum, the Radix Aucklandiae, Lignum Santali Albi, Fructus Aurantii Immaturus, Cortex Magnoliae Officinalis, Rhizoma Chuanxiong, Rhizoma Coptidis or Radix Scutellariae powder are broken into 40-80 purpose powder, CO 2Supercritical extraction, extracting pressure 5-40MPa, temperature 35-60 ℃, CO 2Flow velocity 20-35L/h, extraction 2-5h; Get extract, add an amount of anhydrous alcohol solution,, adopt polishing to carry out enclose,, promptly get clathrate in 40 ℃ of vacuum dryings with an amount of β-CD, subsequent use; Medicinal residues behind the above-mentioned supercritical extraction are added 60% ethanol extraction secondary, merge secondary filtrating, relative density is that 1.25-1.30 is subsequent use when reclaiming ethanol to 60 ℃; Get Fructus Jujubae decocte with water secondary, each 2h filters; Merging filtrate, relative density 1.25-1.30 when being concentrated into 60 ℃, with above-mentioned alcohol extract condensed cream mixing, drying is ground into fine powder, again with clathrate, Semen Crotonis Pulveratum, Moschus mixing, crosses 80 mesh sieves, and is subsequent use;
Perhaps above ten flavor medicines, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is subsequent use; Six-element medicated powder such as Lignum Aquilariae Resinatum, the Radix Aucklandiae, Lignum Santali Albi, Fructus Aurantii Immaturus, Cortex Magnoliae Officinalis, Rhizoma Chuanxiong are broken into coarse powder, add 16 times of water gagings, soak 4 hours, and decocting boils distillation 8h altogether, collects volatile oil, and is after β-CD inclusion, subsequent use; Decocting liquid filters, and relative density 1.25-1.30 was subsequent use when filtrating was concentrated into 60 ℃, and medicinal residues and Rhizoma Coptidis or Radix Scutellariae coarse powder add 70% alcohol reflux 2 times, for the first time 2h; 1h filters for the second time; Merge secondary filtrating, relative density 1.20-1.25 when being concentrated into 60 ℃, drying, subsequent use; Get Fructus Jujubae, add decocting and boil secondary, each 2h filters; Merge secondary filtrating, relative density 1.28-1.32 when being concentrated into 60 ℃, drying, with the above-mentioned fine powder that is dried and crushed into,, subsequent use with bag and thing, Semen Crotonis Pulveratum, Moschus mixing;
Perhaps get the Radix Aucklandiae, Lignum Aquilariae Resinatum, Lignum Santali Albi, Fructus Aurantii, Cortex Magnoliae Officinalis, Rhizoma Chuanxiong, Radix Et Rhizoma Rhei powder and be broken into coarse powder, add 80% alcohol reflux 2 times, 8 times of amounts of alcohol adding amount for the first time, backflow 2h; 6 times of amounts of the alcohol adding amount second time, backflow 1h filters; Merge secondary filtrating, subsequent use; Relative density 1.25-1.30 is subsequent use when concentrating under reduced pressure alcohol extract, 60 ℃ of 60-65 ℃ of simmer down tos; Get Fructus Jujubae, add decocting and boil secondary, add 10 times of amounts of water, backflow 2h for the first time; For the second time add 8 times of amounts of water, backflow 1h filters, and merges secondary filtrating, and is subsequent use; Concentrating under reduced pressure Fructus Jujubae water extract, the clear paste of relative density 1.28-1.32 is subsequent use when 60 ℃ of 80-85 ℃ of following simmer down tos; With above-mentioned gained clear paste drying under reduced pressure, getting dry extract is ground into fine powder and Semen Crotonis Pulveratum, Moschus mixing, crosses 80 mesh sieves, subsequent use;
Perhaps above ten flavors, Semen Crotonis Pulveratum, Moschus pulverize separately become fine powder; Eight flavor medicine decocte with water such as all the other Radix Aucklandiae, Lignum Aquilariae Resinatum 2 times, each 2 hours, collecting decoction filtered, and is condensed into thick paste, in above-mentioned thick paste, adds Semen Crotonis Pulveratum, Moschus powder, and mixing is subsequent use;
Perhaps above crude drug, Semen Crotonis Pulveratum, Moschus pulverize separately become fine powder; All the other crude drug are ground into fine powder, and with Semen Crotonis Pulveratum, Moschus powder facing-up, mixing sieves, and is subsequent use;
Get carbomer 108g, add water 9000g and stir, NaOH regulates pH to 7, adds said mixture 2869g, grinds evenly, promptly gets.
The present invention treats in the Chinese medicine gel of gastrointestinal disease, and the Fructus Aurantii among the step a is a stir-baked Fructus Aurantii in bran; Cortex Magnoliae Officinalis is a Cortex Magnoliae Officinalis (processed with ginger); Fructus Jujubae is that Fructus Jujubae, the Moschus of enucleation is the artificial Moschus.
The present invention treats the method for preparing of the Chinese medicine gel of gastrointestinal disease, and step is following:
A. take off column weight amount proportioning crude drug: the Radix Aucklandiae 150～600g, Lignum Aquilariae Resinatum 150～600g, Fructus Aurantii 150～600g, Lignum Santali Albi 90～360g, Radix Et Rhizoma Rhei 90～360g, Cortex Magnoliae Officinalis 150～600g, Moschus 4.5～18g, Semen Crotonis Pulveratum 60～240g, Fructus Jujubae 500～2000g, Rhizoma Chuanxiong 90～360g are subsequent use;
B. get Semen Crotonis Pulveratum, the Moschus pulverize separately becomes fine powder; The Radix Aucklandiae, Lignum Aquilariae Resinatum, Fructus Aurantii, Lignum Santali Albi, Radix Et Rhizoma Rhei, Cortex Magnoliae Officinalis, Fructus Jujubae, Rhizoma Chuanxiong eight flavors are ground into fine powder; With Semen Crotonis Pulveratum, Moschus powder facing-up, mixing sieves, and is subsequent use;
Perhaps above ten flavor medicines, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is subsequent use; The Radix Aucklandiae, Lignum Aquilariae Resinatum, Lignum Santali Albi, Fructus Aurantii Immaturus, Cortex Magnoliae Officinalis, Rhizoma Chuanxiong, Rhizoma Coptidis or Radix Scutellariae are pulverized, CO 2Supercritical extraction; Get extract, add an amount of anhydrous alcohol solution, carry out enclose with an amount of β-CD, drying promptly gets clathrate, and is subsequent use; With the medicinal residues ethanol extraction secondary behind the above-mentioned supercritical extraction, merge secondary filtrating, reclaim ethanol and concentrate subsequent use; Get Fructus Jujubae decocte with water secondary, filter; Merging filtrate concentrates, and with above-mentioned alcohol extract condensed cream mixing, drying is ground into fine powder, with clathrate, Semen Crotonis Pulveratum, Moschus mixing, sieves again, and is subsequent use;
Perhaps above ten flavor medicines, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is subsequent use; Six-element medicated powder such as Lignum Aquilariae Resinatum, the Radix Aucklandiae, Lignum Santali Albi, Fructus Aurantii Immaturus, Cortex Magnoliae Officinalis, Rhizoma Chuanxiong are broken into coarse powder, add water, soak, and decocting boils distillation, collect volatile oil, and are after β-CD inclusion, subsequent use; Decocting liquid filters, and filtrating concentrates subsequent use, and medicinal residues and Rhizoma Coptidis or Radix Scutellariae coarse powder add alcohol reflux 2 times, filters; Merge secondary filtrating, concentrate, drying, subsequent use; Get Fructus Jujubae, add decocting and boil secondary, filter; Merge secondary filtrating, concentrate, drying, the above-mentioned fine powder that is dried and crushed into, with bag and thing, Semen Crotonis Pulveratum, Moschus mixing, subsequent use;
Perhaps get the Radix Aucklandiae, Lignum Aquilariae Resinatum, Lignum Santali Albi, Fructus Aurantii, Cortex Magnoliae Officinalis, Rhizoma Chuanxiong, Radix Et Rhizoma Rhei powder and be broken into coarse powder, add alcohol reflux, filter; Merging filtrate, subsequent use; The concentrating under reduced pressure alcohol extract concentrates subsequent use; Get Fructus Jujubae, add decocting and boil, filter, concentrating under reduced pressure Fructus Jujubae water extract, the simmer down to clear paste, subsequent use; With above-mentioned gained clear paste drying under reduced pressure, getting dry extract is ground into fine powder and Semen Crotonis Pulveratum, Moschus mixing, sieves, subsequent use;
Perhaps above ten flavors, Semen Crotonis Pulveratum, Moschus pulverize separately become fine powder; All the other eight flavor medicine decocte with water 1～3 time, each 1～3 hour, collecting decoction filtered, and is condensed into thick paste; In above-mentioned thick paste, add Semen Crotonis Pulveratum, Moschus powder, mixing, subsequent use;
Get an amount of carbomer, add water and stir, NaOH regulates pH value, adds said mixture and grinds evenly, promptly gets.
The present invention preferably treats the method for preparing of the Chinese medicine gel of gastrointestinal disease, and step is following:
A. take off column weight amount proportioning crude drug: the Radix Aucklandiae 250～400g, Lignum Aquilariae Resinatum 250～400g, Fructus Aurantii 250～400g, Lignum Santali Albi 150～250g, Radix Et Rhizoma Rhei 150～250g, Cortex Magnoliae Officinalis 250～400g, Moschus 6～12g, Semen Crotonis Pulveratum 100～150g, Fructus Jujubae 800～1200g, Rhizoma Chuanxiong 150～250g are subsequent use;
B. above ten flavor medicines, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is subsequent use; Lignum Aquilariae Resinatum, the Radix Aucklandiae, Lignum Santali Albi, Fructus Aurantii Immaturus, Cortex Magnoliae Officinalis, Rhizoma Chuanxiong, Rhizoma Coptidis or Radix Scutellariae powder are broken into 40-80 purpose powder, CO 2Supercritical extraction, extracting pressure 5-40MPa, temperature 35-60 ℃, CO 2Flow velocity 20-35L/h, extraction 2-5h; Get extract, add an amount of anhydrous alcohol solution,, adopt polishing to carry out enclose,, promptly get clathrate in 40 ℃ of vacuum dryings with an amount of β-CD, subsequent use; Medicinal residues behind the above-mentioned supercritical extraction are added 60% ethanol extraction secondary, merge secondary filtrating, relative density is that 1.25-1.30 is subsequent use when reclaiming ethanol to 60 ℃; Get Fructus Jujubae decocte with water secondary, each 2h filters; Merging filtrate, relative density 1.25-1.30 when being concentrated into 60 ℃, with above-mentioned alcohol extract condensed cream mixing, drying is ground into fine powder, again with clathrate, Semen Crotonis Pulveratum, Moschus mixing, crosses 80 mesh sieves, and is subsequent use;
Perhaps above ten flavor medicines, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is subsequent use; Six-element medicated powder such as Lignum Aquilariae Resinatum, the Radix Aucklandiae, Lignum Santali Albi, Fructus Aurantii Immaturus, Cortex Magnoliae Officinalis, Rhizoma Chuanxiong are broken into coarse powder, add 16 times of water gagings, soak 4 hours, and decocting boils distillation 8h altogether, collects volatile oil, and is after β-CD inclusion, subsequent use; Decocting liquid filters, and relative density 1.25-1.30 was subsequent use when filtrating was concentrated into 60 ℃, and medicinal residues and Rhizoma Coptidis or Radix Scutellariae coarse powder add 70% alcohol reflux 2 times, for the first time 2h; 1h filters for the second time; Merge secondary filtrating, relative density 1.20-1.25 when being concentrated into 60 ℃, drying, subsequent use; Get Fructus Jujubae, add decocting and boil secondary, each 2h filters; Merge secondary filtrating, relative density 1.28-1.32 when being concentrated into 60 ℃, drying, with the above-mentioned fine powder that is dried and crushed into,, subsequent use with bag and thing, Semen Crotonis Pulveratum, Moschus mixing;
Perhaps get the Radix Aucklandiae, Lignum Aquilariae Resinatum, Lignum Santali Albi, Fructus Aurantii, Cortex Magnoliae Officinalis, Rhizoma Chuanxiong, Radix Et Rhizoma Rhei powder and be broken into coarse powder, add 80% alcohol reflux 2 times, 8 times of amounts of alcohol adding amount for the first time, backflow 2h; 6 times of amounts of the alcohol adding amount second time, backflow 1h filters; Merge secondary filtrating, subsequent use; Relative density 1.25-1.30 is subsequent use when concentrating under reduced pressure alcohol extract, 60 ℃ of 60-65 ℃ of simmer down tos; Get Fructus Jujubae, add decocting and boil secondary, add 10 times of amounts of water, backflow 2h for the first time; For the second time add 8 times of amounts of water, backflow 1h filters, and merges secondary filtrating, and is subsequent use; Concentrating under reduced pressure Fructus Jujubae water extract, the clear paste of relative density 1.28-1.32 is subsequent use when 60 ℃ of 80-85 ℃ of following simmer down tos; With above-mentioned gained clear paste drying under reduced pressure, getting dry extract is ground into fine powder and Semen Crotonis Pulveratum, Moschus mixing, crosses 80 mesh sieves, subsequent use;
Perhaps above ten flavors, Semen Crotonis Pulveratum, Moschus pulverize separately become fine powder; Eight flavor medicine decocte with water such as all the other Radix Aucklandiae, Lignum Aquilariae Resinatum 2 times, each 2 hours, collecting decoction filtered, and is condensed into thick paste, in above-mentioned thick paste, adds Semen Crotonis Pulveratum, Moschus powder, and mixing is subsequent use;
Perhaps above crude drug, Semen Crotonis Pulveratum, Moschus pulverize separately become fine powder; All the other crude drug are ground into fine powder, and with Semen Crotonis Pulveratum, Moschus powder facing-up, mixing sieves, and is subsequent use;
Get carbomer 80～200g, add water 5000～20000g and stir, NaOH regulates pH value, adds said mixture 1000～3500g, grinds evenly, promptly gets.
The method for preparing of the Chinese medicine gel of the further preferred treatment gastrointestinal disease of the present invention, step is following:
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 300g, Lignum Aquilariae Resinatum 300g, Fructus Aurantii 300g, Lignum Santali Albi 180g, Radix Et Rhizoma Rhei 180g, Cortex Magnoliae Officinalis 300g, Moschus 9g, Semen Crotonis Pulveratum 120g, Fructus Jujubae 1000g, Rhizoma Chuanxiong 180g are subsequent use;
B. above ten flavor medicines, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is subsequent use; Lignum Aquilariae Resinatum, the Radix Aucklandiae, Lignum Santali Albi, Fructus Aurantii Immaturus, Cortex Magnoliae Officinalis, Rhizoma Chuanxiong, Rhizoma Coptidis or Radix Scutellariae powder are broken into 40-80 purpose powder, CO 2Supercritical extraction, extracting pressure 5-40MPa, temperature 35-60 ℃, CO 2Flow velocity 20-35L/h, extraction 2-5h; Get extract, add an amount of anhydrous alcohol solution,, adopt polishing to carry out enclose,, promptly get clathrate in 40 ℃ of vacuum dryings with an amount of β-CD, subsequent use; Medicinal residues behind the above-mentioned supercritical extraction are added 60% ethanol extraction secondary, merge secondary filtrating, relative density is that 1.25-1.30 is subsequent use when reclaiming ethanol to 60 ℃; Get Fructus Jujubae decocte with water secondary, each 2h filters; Merging filtrate, relative density 1.25-1.30 when being concentrated into 60 ℃, with above-mentioned alcohol extract condensed cream mixing, drying is ground into fine powder, again with clathrate, Semen Crotonis Pulveratum, Moschus mixing, crosses 80 mesh sieves, and is subsequent use;
Perhaps above ten flavor medicines, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is subsequent use; Six-element medicated powder such as Lignum Aquilariae Resinatum, the Radix Aucklandiae, Lignum Santali Albi, Fructus Aurantii Immaturus, Cortex Magnoliae Officinalis, Rhizoma Chuanxiong are broken into coarse powder, add 16 times of water gagings, soak 4 hours, and decocting boils distillation 8h altogether, collects volatile oil, and is after β-CD inclusion, subsequent use; Decocting liquid filters, and relative density 1.25-1.30 was subsequent use when filtrating was concentrated into 60 ℃, and medicinal residues and Rhizoma Coptidis or Radix Scutellariae coarse powder add 70% alcohol reflux 2 times, for the first time 2h; 1h filters for the second time; Merge secondary filtrating, relative density 1.20-1.25 when being concentrated into 60 ℃, drying, subsequent use; Get Fructus Jujubae, add decocting and boil secondary, each 2h filters; Merge secondary filtrating, relative density 1.28-1.32 when being concentrated into 60 ℃, drying, with the above-mentioned fine powder that is dried and crushed into,, subsequent use with bag and thing, Semen Crotonis Pulveratum, Moschus mixing;
Perhaps get the Radix Aucklandiae, Lignum Aquilariae Resinatum, Lignum Santali Albi, Fructus Aurantii, Cortex Magnoliae Officinalis, Rhizoma Chuanxiong, Radix Et Rhizoma Rhei powder and be broken into coarse powder, add 80% alcohol reflux 2 times, 8 times of amounts of alcohol adding amount for the first time, backflow 2h; 6 times of amounts of the alcohol adding amount second time, backflow 1h filters; Merge secondary filtrating, subsequent use; Relative density 1.25-1.30 is subsequent use when concentrating under reduced pressure alcohol extract, 60 ℃ of 60-65 ℃ of simmer down tos; Get Fructus Jujubae, add decocting and boil secondary, add 10 times of amounts of water, backflow 2h for the first time; For the second time add 8 times of amounts of water, backflow 1h filters, and merges secondary filtrating, and is subsequent use; Concentrating under reduced pressure Fructus Jujubae water extract, the clear paste of relative density 1.28-1.32 is subsequent use when 60 ℃ of 80-85 ℃ of following simmer down tos; With above-mentioned gained clear paste drying under reduced pressure, getting dry extract is ground into fine powder and Semen Crotonis Pulveratum, Moschus mixing, crosses 80 mesh sieves, subsequent use;
Perhaps above ten flavors, Semen Crotonis Pulveratum, Moschus pulverize separately become fine powder; Eight flavor medicine decocte with water such as all the other Radix Aucklandiae, Lignum Aquilariae Resinatum 2 times, each 2 hours, collecting decoction filtered, and is condensed into thick paste, in above-mentioned thick paste, adds Semen Crotonis Pulveratum, Moschus powder, and mixing is subsequent use;
Perhaps above crude drug, Semen Crotonis Pulveratum, Moschus pulverize separately become fine powder; All the other crude drug are ground into fine powder, and with Semen Crotonis Pulveratum, Moschus powder facing-up, mixing sieves, and is subsequent use;
Get carbomer 108g, add water 9000g and stir, NaOH regulates pH to 7, adds said mixture 2869g, grinds evenly, promptly gets.
The present invention treats the application of Chinese medicine gel in preparation treatment irritable bowel syndrome medicine of gastrointestinal disease.
The Chinese medicine gel that the present invention treats gastrointestinal disease at preparation treatment acute diarrhea, poor appetite, feel sick, the application in the vomiting, abdominal distention, stomachache, dyspepsia, dysentery, enteritis, lienteric diarrhea medicine
More than form when producing and to increase or to reduce according to corresponding ratio; Like large-scale production can be unit with kilogram or with the ton; Small-scale production can be unit with the gram also, and weight can increase or reduce, but the crude drug material weight proportion constant rate between each composition.
In order to understand the present invention better, logical below Test Example is further set forth the beneficial effect of medicine of the present invention.Below used medicine of the present invention for the ease of narration, below will be called for short medicine of the present invention according to the medicine of embodiment 6 methods preparation according to the preparation of embodiment 6 methods in the test.
Medicine percutaneous dosing treatment irritable boewl syndrome 120 examples of the present invention
1 data and method
1.1 physical data reference 1999 (FGID) is referring to the diagnostic criteria in the II diagnostic criteria of Rome.Case selects hepatic and renal function, erythrocyte sedimentation rate, thyroid profile biochemical analysis normal, and stool inspection and fibercolonscopy are got rid of infectious and ND patient 120 examples.Wherein male 62 examples, women 58 examples; 40.2 years old mean age, course of disease 2-15, average 5.5 years; Diarrhea-type 82 examples, constipation type 38 examples.
1.2 Therapeutic Method
Patient's umbilical part is cleaned with normal saline, then the medicine that mixes up is spread on the part in right amount, for avoiding the too fast drying of pharmacy solution, applies the anti-irritated immobilization with adhesive tape of lid with antiseptic gauze behind one of the square thin film of external application plastics 3cm and gets final product.The umbilical part drug of topical application promptly not too much also can not be very few, and general 10 grams are advisable.Change dressings every day once, treating 20 days was 1 course of treatment.
1.3 criterion of therapeutical effect is with reference to State Administration of Traditional Chinese Medicine " traditional Chinese medical science disease diagnosis criterion of therapeutical effect ", " have loose bowels, constipation " standard rating curative effect.Cure: stomachache, abdominal distention and autonomic nervous dysfunction's symptom and abdominal tenderness sign disappear.Diarrhea-type stool 1 time/day:, stool is shaped, defecation urgency sense and sense disappearance not to the utmost; Constipation type stool 1 time/day, stool is shaped and is unobstructed; Take a turn for the better: stomachache, abdominal distention and autonomic nervous dysfunction's symptom are clearly better, the abdominal tenderness sign alleviates.Diarrhea-type stool＜3 times/day, the stool shape is loose, pasty state, mucus or watery stool all take a favorable turn, and the defecation urgency sense alleviates with feeling all having not to the utmost; Constipation type defecation＞3 time/week, feces is hard or be the sheep stool shape and take a turn for the better, and defecation is than leicht fallen D/A.Invalid: symptom, sign do not have obvious improvement.
2 results: see table 1.
Table 1 curative effect of medication of the present invention is observed
Figure G200810154420XD00091
Table 2 Drug therapy of the present invention observation of curative effect after 3 months
Group Typing (routine number n) Cure Take a turn for the better Invalid Total effective rate (%)
The treatment group Diarrhea-type (94) 70 18 6 93.62
Constipation type (26) 15 7 4 84.62
The result shows that medicine of the present invention has good therapeutic effect.
The specific embodiment
Below further set forth the method for preparing of medicine of the present invention through embodiment.
Embodiment 1:
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 150g, Lignum Aquilariae Resinatum 150g, Fructus Aurantii 150g, Lignum Santali Albi 90g, Radix Et Rhizoma Rhei 90g, Cortex Magnoliae Officinalis 150g, artificial Moschus 4.5g, Semen Crotonis Pulveratum 60g, Fructus Jujubae 500g, Rhizoma Chuanxiong 90g are subsequent use;
B. Semen Crotonis Pulveratum, Moschus pulverize separately become fine powder; The Radix Aucklandiae, Lignum Aquilariae Resinatum, Fructus Aurantii, Lignum Santali Albi, Radix Et Rhizoma Rhei, Cortex Magnoliae Officinalis, Fructus Jujubae, Rhizoma Chuanxiong eight flavors are ground into fine powder; With Semen Crotonis Pulveratum, Moschus powder facing-up, mixing sieves, and is subsequent use; Get an amount of carbomer, add water and stir, NaOH regulates pH value, adds said mixture and grinds evenly, promptly gets.
Embodiment 2:
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 600g, Lignum Aquilariae Resinatum 600g, Fructus Aurantii 600g, Lignum Santali Albi 360g, Radix Et Rhizoma Rhei 360g, Cortex Magnoliae Officinalis 600g, Moschus 18g, Semen Crotonis Pulveratum 240g, Fructus Jujubae 2000g, Rhizoma Chuanxiong 360g are subsequent use;
B. Semen Crotonis Pulveratum, Moschus pulverize separately become fine powder; The Radix Aucklandiae, Lignum Aquilariae Resinatum, Fructus Aurantii, Lignum Santali Albi, Radix Et Rhizoma Rhei, Cortex Magnoliae Officinalis, Fructus Jujubae, Rhizoma Chuanxiong eight flavors are ground into fine powder; With Semen Crotonis Pulveratum, Moschus powder facing-up, mixing sieves, and is subsequent use; Get carbomer 80g, add water 5000g and stir, NaOH regulates pH value, adds said mixture 3500g, grinds evenly, promptly gets.
Embodiment 3:
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 200g, Lignum Aquilariae Resinatum 150g, Fructus Aurantii 600g, Lignum Santali Albi 360g, Radix Et Rhizoma Rhei 90g, Cortex Magnoliae Officinalis 200g, artificial Moschus 10g, Semen Crotonis Pulveratum 80g, Fructus Jujubae 1500g, Rhizoma Chuanxiong 300g are subsequent use;
B. Semen Crotonis Pulveratum, Moschus pulverize separately become fine powder; The Radix Aucklandiae, Lignum Aquilariae Resinatum, Fructus Aurantii, Lignum Santali Albi, Radix Et Rhizoma Rhei, Cortex Magnoliae Officinalis, Fructus Jujubae, Rhizoma Chuanxiong eight flavors are ground into fine powder; With Semen Crotonis Pulveratum, Moschus powder facing-up, mixing sieves, and is subsequent use; Get carbomer 200g, add water 20000g and stir, NaOH regulates pH to 6, adds said mixture 1000g, grinds evenly, promptly gets.
Embodiment 4:
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 250g, Lignum Aquilariae Resinatum 250g, Fructus Aurantii 250g, Lignum Santali Albi 150g, Radix Et Rhizoma Rhei 250g, Cortex Magnoliae Officinalis 250g, Moschus 6g, Semen Crotonis Pulveratum 100g, Fructus Jujubae 800g, Rhizoma Chuanxiong 150g are subsequent use;
B. Semen Crotonis Pulveratum, Moschus pulverize separately become fine powder; The Radix Aucklandiae, Lignum Aquilariae Resinatum, Fructus Aurantii, Lignum Santali Albi, Radix Et Rhizoma Rhei, Cortex Magnoliae Officinalis, Fructus Jujubae, Rhizoma Chuanxiong eight flavors are ground into fine powder; With Semen Crotonis Pulveratum, Moschus powder facing-up, mixing sieves, and is subsequent use; Get carbomer 100g, add water 10000g and stir, NaOH regulates pH to 7, adds said mixture 1500g, grinds evenly, promptly gets.
Embodiment 5:
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 400g, Lignum Aquilariae Resinatum 400g, Fructus Aurantii 400g, Lignum Santali Albi 250g, Radix Et Rhizoma Rhei 250g, Cortex Magnoliae Officinalis 400g, artificial Moschus 12g, Semen Crotonis Pulveratum 150g, Fructus Jujubae 1200g, Rhizoma Chuanxiong 250g are subsequent use;
B. Semen Crotonis Pulveratum, Moschus pulverize separately become fine powder; The Radix Aucklandiae, Lignum Aquilariae Resinatum, Fructus Aurantii, Lignum Santali Albi, Radix Et Rhizoma Rhei, Cortex Magnoliae Officinalis, Fructus Jujubae, Rhizoma Chuanxiong eight flavors are ground into fine powder; With Semen Crotonis Pulveratum, Moschus powder facing-up, mixing sieves, and is subsequent use; Get carbomer 120g, add water 15000g and stir, NaOH regulates pH to 8, adds said mixture 2500g, grinds evenly, promptly gets.
Embodiment 6
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 300g, Lignum Aquilariae Resinatum 300g, Fructus Aurantii (parched with bran) 300g, Lignum Santali Albi 180g, Radix Et Rhizoma Rhei 180g, Cortex Magnoliae Officinalis (Rhizoma Zingiberis Recens is processed) 300g, Moschus 9g, Semen Crotonis Pulveratum 120g, Fructus Jujubae (enucleation) 1000g, Rhizoma Chuanxiong 180g are subsequent use;
B. Semen Crotonis Pulveratum, Moschus pulverize separately become fine powder; The Radix Aucklandiae, Lignum Aquilariae Resinatum, Fructus Aurantii, Lignum Santali Albi, Radix Et Rhizoma Rhei, Cortex Magnoliae Officinalis, Fructus Jujubae, Rhizoma Chuanxiong eight flavors are ground into fine powder; With Semen Crotonis Pulveratum, Moschus powder facing-up, mixing sieves, and is subsequent use; Get carbomer 108g, add water 9000g and stir, NaOH regulates pH to 7, adds said mixture 2869g, grinds evenly, promptly gets.
Embodiment 7
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 250g, Lignum Aquilariae Resinatum 300g, Fructus Aurantii (parched with bran) 250g, Lignum Santali Albi 180g, Radix Et Rhizoma Rhei 180g, Cortex Magnoliae Officinalis (Rhizoma Zingiberis Recens is processed) 300g, Moschus 9g, Semen Crotonis Pulveratum 120g, Fructus Jujubae (enucleation) 1200g, Rhizoma Chuanxiong 180g are subsequent use;
B. Semen Crotonis Pulveratum, Moschus pulverize separately become fine powder; The Radix Aucklandiae, Lignum Aquilariae Resinatum, Fructus Aurantii, Lignum Santali Albi, Radix Et Rhizoma Rhei, Cortex Magnoliae Officinalis, Fructus Jujubae, Rhizoma Chuanxiong eight flavors are ground into fine powder; With Semen Crotonis Pulveratum, Moschus powder facing-up, mixing sieves, and is subsequent use; Get carbomer 158g, add water 8000g and stir, NaOH regulates pH to 7, adds said mixture 1869g, grinds evenly, promptly gets.
Embodiment 8
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 300g, Lignum Aquilariae Resinatum 300g, Fructus Aurantii 300g, Lignum Santali Albi 180g, Radix Et Rhizoma Rhei 180g, Cortex Magnoliae Officinalis 300g, Moschus 9g, Semen Crotonis Pulveratum 120g, Fructus Jujubae 1000g, Rhizoma Chuanxiong 180g are subsequent use;
B. Semen Crotonis Pulveratum, Moschus pulverize separately become fine powder; The Radix Aucklandiae, Lignum Aquilariae Resinatum, Fructus Aurantii, Lignum Santali Albi, Radix Et Rhizoma Rhei, Cortex Magnoliae Officinalis, Fructus Jujubae, Rhizoma Chuanxiong eight flavors are ground into fine powder; With Semen Crotonis Pulveratum, Moschus powder facing-up, mixing sieves, and is subsequent use; Get carbomer 88g, add water 10000g and stir, NaOH regulates pH to 7, adds said mixture 2500g, grinds evenly, promptly gets.
Embodiment 9
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 300g, Lignum Aquilariae Resinatum 300g, Fructus Aurantii 300g, Lignum Santali Albi 180g, Radix Et Rhizoma Rhei 180g, Cortex Magnoliae Officinalis 300g, artificial Moschus 9g, Semen Crotonis Pulveratum 120g, Fructus Jujubae 1000g, Rhizoma Chuanxiong 180g are subsequent use;
B. Semen Crotonis Pulveratum, Moschus pulverize separately become fine powder; The Radix Aucklandiae, Lignum Aquilariae Resinatum, Fructus Aurantii, Lignum Santali Albi, Radix Et Rhizoma Rhei, Cortex Magnoliae Officinalis, Fructus Jujubae, Rhizoma Chuanxiong eight flavors are ground into fine powder; With Semen Crotonis Pulveratum, Moschus powder facing-up, mixing sieves, and is subsequent use; Get carbomer 85g, add water 7500g and stir, NaOH regulates pH to 7, adds said mixture 2059g, grinds evenly, promptly gets.
Embodiment 10
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 300g, Lignum Aquilariae Resinatum 350g, Fructus Aurantii (parched with bran) 350g, Lignum Santali Albi 200g, Radix Et Rhizoma Rhei 200g, Cortex Magnoliae Officinalis (Rhizoma Zingiberis Recens is processed) 300g, Moschus 7g, Semen Crotonis Pulveratum 120g, Fructus Jujubae (enucleation) 1000g, Rhizoma Chuanxiong 200g are subsequent use;
B. Semen Crotonis Pulveratum, Moschus pulverize separately become fine powder; The Radix Aucklandiae, Lignum Aquilariae Resinatum, Fructus Aurantii, Lignum Santali Albi, Radix Et Rhizoma Rhei, Cortex Magnoliae Officinalis, Fructus Jujubae, Rhizoma Chuanxiong eight flavors are ground into fine powder; With Semen Crotonis Pulveratum, Moschus powder facing-up, mixing sieves, and is subsequent use; Get carbomer 188g, add water 14000g and stir, NaOH regulates pH to 7, adds said mixture 1800g, grinds evenly, promptly gets.
Embodiment 11
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 500g, Lignum Aquilariae Resinatum 300g, Fructus Aurantii 450g, Lignum Santali Albi 100g, Radix Et Rhizoma Rhei 200g, Cortex Magnoliae Officinalis 600g, Moschus 10g, Semen Crotonis Pulveratum 60g, Fructus Jujubae 800g, Rhizoma Chuanxiong 160g are subsequent use;
B. Semen Crotonis Pulveratum, Moschus pulverize separately become fine powder; The Radix Aucklandiae, Lignum Aquilariae Resinatum, Fructus Aurantii, Lignum Santali Albi, Radix Et Rhizoma Rhei, Cortex Magnoliae Officinalis, Fructus Jujubae, Rhizoma Chuanxiong eight flavors are ground into fine powder; With Semen Crotonis Pulveratum, Moschus powder facing-up, mixing sieves, and is subsequent use; Get carbomer 120g, add water 12000g and stir, NaOH regulates pH to 7, adds said mixture 1400g, grinds evenly, promptly gets.
Embodiment 12
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 150g, Lignum Aquilariae Resinatum 150g, Fructus Aurantii 150g, Lignum Santali Albi 90g, Radix Et Rhizoma Rhei 90g, Cortex Magnoliae Officinalis 150g, Moschus 4.5g, Semen Crotonis Pulveratum 60g, Fructus Jujubae 500g, Rhizoma Chuanxiong 90g are subsequent use;
B. above ten flavor medicines, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is subsequent use; The Radix Aucklandiae, Lignum Aquilariae Resinatum, Lignum Santali Albi, Fructus Aurantii Immaturus, Cortex Magnoliae Officinalis, Rhizoma Chuanxiong, Rhizoma Coptidis or Radix Scutellariae are pulverized, CO 2Supercritical extraction; Get extract, add an amount of anhydrous alcohol solution, carry out enclose with an amount of β-CD, drying promptly gets clathrate, and is subsequent use; With the medicinal residues ethanol extraction secondary behind the above-mentioned supercritical extraction, merge secondary filtrating, reclaim ethanol and concentrate subsequent use; Get Fructus Jujubae decocte with water secondary, filter; Merging filtrate concentrates, and with above-mentioned alcohol extract condensed cream mixing, drying is ground into fine powder, with clathrate, Semen Crotonis Pulveratum, Moschus mixing, sieves again, and is subsequent use; Get an amount of carbomer, add water and stir, NaOH regulates pH value, adds said mixture and grinds evenly, promptly gets.
Embodiment 13
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 150g, Lignum Aquilariae Resinatum 150g, Fructus Aurantii 150g, Lignum Santali Albi 90g, Radix Et Rhizoma Rhei 90g, Cortex Magnoliae Officinalis 150g, Moschus 4.5g, Semen Crotonis Pulveratum 60g, Fructus Jujubae 500g, Rhizoma Chuanxiong 90g are subsequent use;
B. above ten flavor medicines, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is subsequent use; Six-element medicated powder such as Lignum Aquilariae Resinatum, the Radix Aucklandiae, Lignum Santali Albi, Fructus Aurantii Immaturus, Cortex Magnoliae Officinalis, Rhizoma Chuanxiong are broken into coarse powder, add water, soak, and decocting boils distillation, collect volatile oil, and are after β-CD inclusion, subsequent use; Decocting liquid filters, and filtrating concentrates subsequent use, and medicinal residues and Rhizoma Coptidis or Radix Scutellariae coarse powder add alcohol reflux 2 times, filters; Merge secondary filtrating, concentrate, drying, subsequent use; Get Fructus Jujubae, add decocting and boil secondary, filter; Merge secondary filtrating, concentrate, drying, the above-mentioned fine powder that is dried and crushed into, with bag and thing, Semen Crotonis Pulveratum, Moschus mixing, subsequent use; Get an amount of carbomer, add water and stir, NaOH regulates pH value, adds said mixture and grinds evenly, promptly gets.
Embodiment 14
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 150g, Lignum Aquilariae Resinatum 150g, Fructus Aurantii 150g, Lignum Santali Albi 90g, Radix Et Rhizoma Rhei 90g, Cortex Magnoliae Officinalis 150g, Moschus 4.5g, Semen Crotonis Pulveratum 60g, Fructus Jujubae 500g, Rhizoma Chuanxiong 90g are subsequent use;
B. get the Radix Aucklandiae, Lignum Aquilariae Resinatum, Lignum Santali Albi, Fructus Aurantii, Cortex Magnoliae Officinalis, Rhizoma Chuanxiong, Radix Et Rhizoma Rhei powder and be broken into coarse powder, add alcohol reflux, filter; Merging filtrate, subsequent use; The concentrating under reduced pressure alcohol extract concentrates subsequent use; Get Fructus Jujubae, add decocting and boil, filter, concentrating under reduced pressure Fructus Jujubae water extract, the simmer down to clear paste, subsequent use; With above-mentioned gained clear paste drying under reduced pressure, getting dry extract is ground into fine powder and Semen Crotonis Pulveratum, Moschus mixing, sieves, subsequent use; Get an amount of carbomer, add water and stir, NaOH regulates pH value, adds said mixture and grinds evenly, promptly gets.
Embodiment 15
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 150g, Lignum Aquilariae Resinatum 150g, Fructus Aurantii 150g, Lignum Santali Albi 90g, Radix Et Rhizoma Rhei 90g, Cortex Magnoliae Officinalis 150g, Moschus 4.5g, Semen Crotonis Pulveratum 60g, Fructus Jujubae 500g, Rhizoma Chuanxiong 90g are subsequent use;
B. above ten flavors, Semen Crotonis Pulveratum, Moschus pulverize separately become fine powder; All the other eight flavor medicine decocte with water 2 times, each 1 hour, collecting decoction filtered, and is condensed into thick paste; In above-mentioned thick paste, add Semen Crotonis Pulveratum, Moschus powder, mixing, subsequent use; Get an amount of carbomer, add water and stir, NaOH regulates pH value, adds said mixture and grinds evenly, promptly gets.
Embodiment 16
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 600g, Lignum Aquilariae Resinatum 600g, Fructus Aurantii 600g, Lignum Santali Albi 360g, Radix Et Rhizoma Rhei 360g, Cortex Magnoliae Officinalis 600g, Moschus 18g, Semen Crotonis Pulveratum 240g, Fructus Jujubae 2000g, Rhizoma Chuanxiong 360g are subsequent use;
B. above ten flavor medicines, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is subsequent use; The Radix Aucklandiae, Lignum Aquilariae Resinatum, Lignum Santali Albi, Fructus Aurantii Immaturus, Cortex Magnoliae Officinalis, Rhizoma Chuanxiong, Rhizoma Coptidis or Radix Scutellariae are pulverized, CO 2Supercritical extraction; Get extract, add an amount of anhydrous alcohol solution, carry out enclose with an amount of β-CD, drying promptly gets clathrate, and is subsequent use; With the medicinal residues ethanol extraction secondary behind the above-mentioned supercritical extraction, merge secondary filtrating, reclaim ethanol and concentrate subsequent use; Get Fructus Jujubae decocte with water secondary, filter; Merging filtrate concentrates, and with above-mentioned alcohol extract condensed cream mixing, drying is ground into fine powder, with clathrate, Semen Crotonis Pulveratum, Moschus mixing, sieves again, and is subsequent use; Get an amount of carbomer, add water and stir, NaOH regulates pH value, adds said mixture and grinds evenly, promptly gets.
Embodiment 17
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 600g, Lignum Aquilariae Resinatum 600g, Fructus Aurantii 600g, Lignum Santali Albi 360g, Radix Et Rhizoma Rhei 360g, Cortex Magnoliae Officinalis 600g, Moschus 18g, Semen Crotonis Pulveratum 240g, Fructus Jujubae 2000g, Rhizoma Chuanxiong 360g are subsequent use;
B. above ten flavor medicines, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is subsequent use; Six-element medicated powder such as Lignum Aquilariae Resinatum, the Radix Aucklandiae, Lignum Santali Albi, Fructus Aurantii Immaturus, Cortex Magnoliae Officinalis, Rhizoma Chuanxiong are broken into coarse powder, add water, soak, and decocting boils distillation, collect volatile oil, and are after β-CD inclusion, subsequent use; Decocting liquid filters, and filtrating concentrates subsequent use, and medicinal residues and Rhizoma Coptidis or Radix Scutellariae coarse powder add alcohol reflux 2 times, filters; Merge secondary filtrating, concentrate, drying, subsequent use; Get Fructus Jujubae, add decocting and boil secondary, filter; Merge secondary filtrating, concentrate, drying, the above-mentioned fine powder that is dried and crushed into, with bag and thing, Semen Crotonis Pulveratum, Moschus mixing, subsequent use; Get an amount of carbomer, add water and stir, NaOH regulates pH value, adds said mixture and grinds evenly, promptly gets.
Embodiment 18
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 600g, Lignum Aquilariae Resinatum 600g, Fructus Aurantii 600g, Lignum Santali Albi 360g, Radix Et Rhizoma Rhei 360g, Cortex Magnoliae Officinalis 600g, Moschus 18g, Semen Crotonis Pulveratum 240g, Fructus Jujubae 2000g, Rhizoma Chuanxiong 360g are subsequent use;
B. get the Radix Aucklandiae, Lignum Aquilariae Resinatum, Lignum Santali Albi, Fructus Aurantii, Cortex Magnoliae Officinalis, Rhizoma Chuanxiong, Radix Et Rhizoma Rhei powder and be broken into coarse powder, add alcohol reflux, filter; Merging filtrate, subsequent use; The concentrating under reduced pressure alcohol extract concentrates subsequent use; Get Fructus Jujubae, add decocting and boil, filter, concentrating under reduced pressure Fructus Jujubae water extract, the simmer down to clear paste, subsequent use; With above-mentioned gained clear paste drying under reduced pressure, getting dry extract is ground into fine powder and Semen Crotonis Pulveratum, Moschus mixing, sieves, subsequent use; Get an amount of carbomer, add water and stir, NaOH regulates pH value, adds said mixture and grinds evenly, promptly gets.
Embodiment 19
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 600g, Lignum Aquilariae Resinatum 600g, Fructus Aurantii 600g, Lignum Santali Albi 360g, Radix Et Rhizoma Rhei 360g, Cortex Magnoliae Officinalis 600g, Moschus 18g, Semen Crotonis Pulveratum 240g, Fructus Jujubae 2000g, Rhizoma Chuanxiong 360g are subsequent use;
B. above ten flavors, Semen Crotonis Pulveratum, Moschus pulverize separately become fine powder; All the other eight flavor medicine decocte with water 3 times, each 3 hours, collecting decoction filtered, and is condensed into thick paste; In above-mentioned thick paste, add Semen Crotonis Pulveratum, Moschus powder, mixing, subsequent use; Get an amount of carbomer, add water and stir, NaOH regulates pH value, adds said mixture and grinds evenly, promptly gets.
Embodiment 20
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 250g, Lignum Aquilariae Resinatum 250g, Fructus Aurantii 250g, Lignum Santali Albi 150g, Radix Et Rhizoma Rhei 150g, Cortex Magnoliae Officinalis 250g, Moschus 6g, Semen Crotonis Pulveratum 100g, Fructus Jujubae 800g, Rhizoma Chuanxiong 150g are subsequent use;
B. above ten flavor medicines, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is subsequent use; Lignum Aquilariae Resinatum, the Radix Aucklandiae, Lignum Santali Albi, Fructus Aurantii Immaturus, Cortex Magnoliae Officinalis, Rhizoma Chuanxiong, Rhizoma Coptidis or Radix Scutellariae powder are broken into 40 purpose powder, CO 2Supercritical extraction, extracting pressure 5MPa, temperature 35-60 ℃, CO 2Flow velocity 20L/h, extraction 2h; Get extract, add an amount of anhydrous alcohol solution,, adopt polishing to carry out enclose,, promptly get clathrate in 40 ℃ of vacuum dryings with an amount of β-CD, subsequent use; Medicinal residues behind the above-mentioned supercritical extraction are added 60% ethanol extraction secondary, merge secondary filtrating, relative density is that 1.25-1.30 is subsequent use when reclaiming ethanol to 60 ℃; Get Fructus Jujubae decocte with water secondary, each 2h filters; Merging filtrate, relative density 1.25-1.30 when being concentrated into 60 ℃, with above-mentioned alcohol extract condensed cream mixing, drying is ground into fine powder, again with clathrate, Semen Crotonis Pulveratum, Moschus mixing, crosses 80 mesh sieves, and is subsequent use; Get carbomer 80g, add water 5000g and stir, NaOH regulates pH value, adds said mixture 1000g, grinds evenly, promptly gets.
Embodiment 21
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 250g, Lignum Aquilariae Resinatum 250g, Fructus Aurantii 250g, Lignum Santali Albi 150g, Radix Et Rhizoma Rhei 150g, Cortex Magnoliae Officinalis 250g, Moschus 6g, Semen Crotonis Pulveratum 100g, Fructus Jujubae 800g, Rhizoma Chuanxiong 150g are subsequent use;
B. above ten flavor medicines, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is subsequent use; Six-element medicated powder such as Lignum Aquilariae Resinatum, the Radix Aucklandiae, Lignum Santali Albi, Fructus Aurantii Immaturus, Cortex Magnoliae Officinalis, Rhizoma Chuanxiong are broken into coarse powder, add 16 times of water gagings, soak 4 hours, and decocting boils distillation 8h altogether, collects volatile oil, and is after β-CD inclusion, subsequent use; Decocting liquid filters, and relative density 1.25-1.30 was subsequent use when filtrating was concentrated into 60 ℃, and medicinal residues and Rhizoma Coptidis or Radix Scutellariae coarse powder add 70% alcohol reflux 2 times, for the first time 2h; 1h filters for the second time; Merge secondary filtrating, relative density 1.20-1.25 when being concentrated into 60 ℃, drying, subsequent use; Get Fructus Jujubae, add decocting and boil secondary, each 2h filters; Merge secondary filtrating, relative density 1.28-1.32 when being concentrated into 60 ℃, drying, with the above-mentioned fine powder that is dried and crushed into,, subsequent use with bag and thing, Semen Crotonis Pulveratum, Moschus mixing; Get carbomer 80g, add water 5000g and stir, NaOH regulates pH value, adds said mixture 1000g, grinds evenly, promptly gets.
Embodiment 22
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 250g, Lignum Aquilariae Resinatum 250g, Fructus Aurantii 250g, Lignum Santali Albi 150g, Radix Et Rhizoma Rhei 150g, Cortex Magnoliae Officinalis 250g, Moschus 6g, Semen Crotonis Pulveratum 100g, Fructus Jujubae 800g, Rhizoma Chuanxiong 150g are subsequent use;
B. get the Radix Aucklandiae, Lignum Aquilariae Resinatum, Lignum Santali Albi, Fructus Aurantii, Cortex Magnoliae Officinalis, Rhizoma Chuanxiong, Radix Et Rhizoma Rhei powder and be broken into coarse powder, add 80% alcohol reflux 2 times, 8 times of amounts of alcohol adding amount for the first time, backflow 2h; 6 times of amounts of the alcohol adding amount second time, backflow 1h filters; Merge secondary filtrating, subsequent use; Relative density 1.25-1.30 is subsequent use when concentrating under reduced pressure alcohol extract, 60 ℃ of 60-65 ℃ of simmer down tos; Get Fructus Jujubae, add decocting and boil secondary, add 10 times of amounts of water, backflow 2h for the first time; For the second time add 8 times of amounts of water, backflow 1h filters, and merges secondary filtrating, and is subsequent use; Concentrating under reduced pressure Fructus Jujubae water extract, the clear paste of relative density 1.28-1.32 is subsequent use when 60 ℃ of 80-85 ℃ of following simmer down tos; With above-mentioned gained clear paste drying under reduced pressure, getting dry extract is ground into fine powder and Semen Crotonis Pulveratum, Moschus mixing, crosses 80 mesh sieves, subsequent use; Get carbomer 80g, add water 5000g and stir, NaOH regulates pH value, adds said mixture 1000g, grinds evenly, promptly gets.
Embodiment 23
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 250g, Lignum Aquilariae Resinatum 250g, Fructus Aurantii 250g, Lignum Santali Albi 150g, Radix Et Rhizoma Rhei 150g, Cortex Magnoliae Officinalis 250g, Moschus 6g, Semen Crotonis Pulveratum 100g, Fructus Jujubae 800g, Rhizoma Chuanxiong 150g are subsequent use;
B. above ten flavors, Semen Crotonis Pulveratum, Moschus pulverize separately become fine powder; Eight flavor medicine decocte with water such as all the other Radix Aucklandiae, Lignum Aquilariae Resinatum 2 times, each 2 hours, collecting decoction filtered, and is condensed into thick paste, in above-mentioned thick paste, adds Semen Crotonis Pulveratum, Moschus powder, and mixing is subsequent use; Get carbomer 80g, add water 5000g and stir, NaOH regulates pH value, adds said mixture 1000g, grinds evenly, promptly gets.
Embodiment 24
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 400g, Lignum Aquilariae Resinatum 400g, Fructus Aurantii 400g, Lignum Santali Albi 250g, Radix Et Rhizoma Rhei 250g, Cortex Magnoliae Officinalis 400g, Moschus 12g, Semen Crotonis Pulveratum 150g, Fructus Jujubae 1200g, Rhizoma Chuanxiong 250g are subsequent use;
B. above ten flavor medicines, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is subsequent use; Lignum Aquilariae Resinatum, the Radix Aucklandiae, Lignum Santali Albi, Fructus Aurantii Immaturus, Cortex Magnoliae Officinalis, Rhizoma Chuanxiong, Rhizoma Coptidis or Radix Scutellariae powder are broken into 80 purpose powder, CO 2Supercritical extraction, extracting pressure 40MPa, 60 ℃ of temperature, CO 2Flow velocity 35L/h, extraction 5h; Get extract, add an amount of anhydrous alcohol solution,, adopt polishing to carry out enclose,, promptly get clathrate in 40 ℃ of vacuum dryings with an amount of β-CD, subsequent use; Medicinal residues behind the above-mentioned supercritical extraction are added 60% ethanol extraction secondary, merge secondary filtrating, relative density is that 1.25-1.30 is subsequent use when reclaiming ethanol to 60 ℃; Get Fructus Jujubae decocte with water secondary, each 2h filters; Merging filtrate, relative density 1.25-1.30 when being concentrated into 60 ℃, with above-mentioned alcohol extract condensed cream mixing, drying is ground into fine powder, again with clathrate, Semen Crotonis Pulveratum, Moschus mixing, crosses 80 mesh sieves, and is subsequent use; Get carbomer 200g, add water 20000g and stir, NaOH regulates pH value, adds said mixture 3500g, grinds evenly, promptly gets.
Embodiment 25
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 400g, Lignum Aquilariae Resinatum 400g, Fructus Aurantii 400g, Lignum Santali Albi 250g, Radix Et Rhizoma Rhei 250g, Cortex Magnoliae Officinalis 400g, Moschus 12g, Semen Crotonis Pulveratum 150g, Fructus Jujubae 1200g, Rhizoma Chuanxiong 250g are subsequent use;
B. above ten flavor medicines, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is subsequent use; Six-element medicated powder such as Lignum Aquilariae Resinatum, the Radix Aucklandiae, Lignum Santali Albi, Fructus Aurantii Immaturus, Cortex Magnoliae Officinalis, Rhizoma Chuanxiong are broken into coarse powder, add 16 times of water gagings, soak 4 hours, and decocting boils distillation 8h altogether, collects volatile oil, and is after β-CD inclusion, subsequent use; Decocting liquid filters, and relative density 1.25-1.30 was subsequent use when filtrating was concentrated into 60 ℃, and medicinal residues and Rhizoma Coptidis or Radix Scutellariae coarse powder add 70% alcohol reflux 2 times, for the first time 2h; 1h filters for the second time; Merge secondary filtrating, relative density 1.20-1.25 when being concentrated into 60 ℃, drying, subsequent use; Get Fructus Jujubae, add decocting and boil secondary, each 2h filters; Merge secondary filtrating, relative density 1.28-1.32 when being concentrated into 60 ℃, drying, with the above-mentioned fine powder that is dried and crushed into,, subsequent use with bag and thing, Semen Crotonis Pulveratum, Moschus mixing; Get carbomer 200g, add water 20000g and stir, NaOH regulates pH value, adds said mixture 3500g, grinds evenly, promptly gets.
Embodiment 26
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 400g, Lignum Aquilariae Resinatum 400g, Fructus Aurantii 400g, Lignum Santali Albi 250g, Radix Et Rhizoma Rhei 250g, Cortex Magnoliae Officinalis 400g, Moschus 12g, Semen Crotonis Pulveratum 150g, Fructus Jujubae 1200g, Rhizoma Chuanxiong 250g are subsequent use;
B. get the Radix Aucklandiae, Lignum Aquilariae Resinatum, Lignum Santali Albi, Fructus Aurantii, Cortex Magnoliae Officinalis, Rhizoma Chuanxiong, Radix Et Rhizoma Rhei powder and be broken into coarse powder, add 80% alcohol reflux 2 times, 8 times of amounts of alcohol adding amount for the first time, backflow 2h; 6 times of amounts of the alcohol adding amount second time, backflow 1h filters; Merge secondary filtrating, subsequent use; Relative density 1.25-1.30 is subsequent use when concentrating under reduced pressure alcohol extract, 60 ℃ of 65 ℃ of simmer down tos; Get Fructus Jujubae, add decocting and boil secondary, add 10 times of amounts of water, backflow 2h for the first time; For the second time add 8 times of amounts of water, backflow 1h filters, and merges secondary filtrating, and is subsequent use; Concentrating under reduced pressure Fructus Jujubae water extract, the clear paste of relative density 1.28-1.32 is subsequent use when 60 ℃ of 85 ℃ of following simmer down tos; With above-mentioned gained clear paste drying under reduced pressure, getting dry extract is ground into fine powder and Semen Crotonis Pulveratum, Moschus mixing, crosses 80 mesh sieves, subsequent use; Get carbomer 200g, add water 20000g and stir, NaOH regulates pH value, adds said mixture 3500g, grinds evenly, promptly gets.
Embodiment 27
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 400g, Lignum Aquilariae Resinatum 400g, Fructus Aurantii 400g, Lignum Santali Albi 250g, Radix Et Rhizoma Rhei 250g, Cortex Magnoliae Officinalis 400g, Moschus 12g, Semen Crotonis Pulveratum 150g, Fructus Jujubae 1200g, Rhizoma Chuanxiong 250g are subsequent use;
B. above ten flavors, Semen Crotonis Pulveratum, Moschus pulverize separately become fine powder; Eight flavor medicine decocte with water such as all the other Radix Aucklandiae, Lignum Aquilariae Resinatum 2 times, each 2 hours, collecting decoction filtered, and is condensed into thick paste, in above-mentioned thick paste, adds Semen Crotonis Pulveratum, Moschus powder, and mixing is subsequent use; Get carbomer 200g, add water 20000g and stir, NaOH regulates pH value, adds said mixture 3500g, grinds evenly, promptly gets.
Embodiment 28
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 300g, Lignum Aquilariae Resinatum 300g, Fructus Aurantii 300g, Lignum Santali Albi 180g, Radix Et Rhizoma Rhei 180g, Cortex Magnoliae Officinalis 300g, Moschus 9g, Semen Crotonis Pulveratum 120g, Fructus Jujubae 1000g, Rhizoma Chuanxiong 180g are subsequent use;
B. above ten flavor medicines, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is subsequent use; Lignum Aquilariae Resinatum, the Radix Aucklandiae, Lignum Santali Albi, Fructus Aurantii Immaturus, Cortex Magnoliae Officinalis, Rhizoma Chuanxiong, Rhizoma Coptidis or Radix Scutellariae powder are broken into 40-80 purpose powder, CO 2Supercritical extraction, extracting pressure 5-40MPa, temperature 35-60 ℃, CO 2Flow velocity 20-35L/h, extraction 2-5h; Get extract, add an amount of anhydrous alcohol solution,, adopt polishing to carry out enclose,, promptly get clathrate in 40 ℃ of vacuum dryings with an amount of β-CD, subsequent use; Medicinal residues behind the above-mentioned supercritical extraction are added 60% ethanol extraction secondary, merge secondary filtrating, relative density is that 1.25-1.30 is subsequent use when reclaiming ethanol to 60 ℃; Get Fructus Jujubae decocte with water secondary, each 2h filters; Merging filtrate, relative density 1.25-1.30 when being concentrated into 60 ℃, with above-mentioned alcohol extract condensed cream mixing, drying is ground into fine powder, again with clathrate, Semen Crotonis Pulveratum, Moschus mixing, crosses 80 mesh sieves, and is subsequent use; Get carbomer 108g, add water 9000g and stir, NaOH regulates pH to 7, adds said mixture 2869g, grinds evenly, promptly gets.
Embodiment 29
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 300g, Lignum Aquilariae Resinatum 300g, Fructus Aurantii 300g, Lignum Santali Albi 180g, Radix Et Rhizoma Rhei 180g, Cortex Magnoliae Officinalis 300g, Moschus 9g, Semen Crotonis Pulveratum 120g, Fructus Jujubae 1000g, Rhizoma Chuanxiong 180g are subsequent use;
B. above ten flavor medicines, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is subsequent use; Six-element medicated powder such as Lignum Aquilariae Resinatum, the Radix Aucklandiae, Lignum Santali Albi, Fructus Aurantii Immaturus, Cortex Magnoliae Officinalis, Rhizoma Chuanxiong are broken into coarse powder, add 16 times of water gagings, soak 4 hours, and decocting boils distillation 8h altogether, collects volatile oil, and is after β-CD inclusion, subsequent use; Decocting liquid filters, and relative density 1.25-1.30 was subsequent use when filtrating was concentrated into 60 ℃, and medicinal residues and Rhizoma Coptidis or Radix Scutellariae coarse powder add 70% alcohol reflux 2 times, for the first time 2h; 1h filters for the second time; Merge secondary filtrating, relative density 1.20-1.25 when being concentrated into 60 ℃, drying, subsequent use; Get Fructus Jujubae, add decocting and boil secondary, each 2h filters; Merge secondary filtrating, relative density 1.28-1.32 when being concentrated into 60 ℃, drying, with the above-mentioned fine powder that is dried and crushed into,, subsequent use with bag and thing, Semen Crotonis Pulveratum, Moschus mixing; Get carbomer 108g, add water 9000g and stir, NaOH regulates pH to 7, adds said mixture 2869g, grinds evenly, promptly gets.
Embodiment 31
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 300g, Lignum Aquilariae Resinatum 300g, Fructus Aurantii 300g, Lignum Santali Albi 180g, Radix Et Rhizoma Rhei 180g, Cortex Magnoliae Officinalis 300g, Moschus 9g, Semen Crotonis Pulveratum 120g, Fructus Jujubae 1000g, Rhizoma Chuanxiong 180g are subsequent use;
B. get the Radix Aucklandiae, Lignum Aquilariae Resinatum, Lignum Santali Albi, Fructus Aurantii, Cortex Magnoliae Officinalis, Rhizoma Chuanxiong, Radix Et Rhizoma Rhei powder and be broken into coarse powder, add 80% alcohol reflux 2 times, 8 times of amounts of alcohol adding amount for the first time, backflow 2h; 6 times of amounts of the alcohol adding amount second time, backflow 1h filters; Merge secondary filtrating, subsequent use; Relative density 1.25-1.30 is subsequent use when concentrating under reduced pressure alcohol extract, 60 ℃ of 60-65 ℃ of simmer down tos; Get Fructus Jujubae, add decocting and boil secondary, add 10 times of amounts of water, backflow 2h for the first time; For the second time add 8 times of amounts of water, backflow 1h filters, and merges secondary filtrating, and is subsequent use; Concentrating under reduced pressure Fructus Jujubae water extract, the clear paste of relative density 1.28-1.32 is subsequent use when 60 ℃ of 80-85 ℃ of following simmer down tos; Get carbomer 108g, add water 9000g and stir, NaOH regulates pH to 7, adds said mixture 2869g, grinds evenly, promptly gets.
Embodiment 32
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 300g, Lignum Aquilariae Resinatum 300g, Fructus Aurantii 300g, Lignum Santali Albi 180g, Radix Et Rhizoma Rhei 180g, Cortex Magnoliae Officinalis 300g, Moschus 9g, Semen Crotonis Pulveratum 120g, Fructus Jujubae 1000g, Rhizoma Chuanxiong 180g are subsequent use;
B. above ten flavors, Semen Crotonis Pulveratum, Moschus pulverize separately become fine powder; Eight flavor medicine decocte with water such as all the other Radix Aucklandiae, Lignum Aquilariae Resinatum 2 times, each 2 hours, collecting decoction filtered, and is condensed into thick paste, in above-mentioned thick paste, adds Semen Crotonis Pulveratum, Moschus powder, and mixing is subsequent use; Get carbomer 108g, add water 9000g and stir, NaOH regulates pH to 7, adds said mixture 2869g, grinds evenly, promptly gets.

Claims (3)

1. method for preparing of treating the Chinese medicine gel of gastrointestinal disease is characterized in that step is following:
A. take off column weight amount proportioning crude drug: the Radix Aucklandiae 150～600g, Lignum Aquilariae Resinatum 150～600g, Fructus Aurantii 150～600g, Lignum Santali Albi 90～360g, Radix Et Rhizoma Rhei 90～360g, Cortex Magnoliae Officinalis 150～600g, Moschus 4.5～18g, Semen Crotonis Pulveratum 60～240g, Fructus Jujubae 500～2000g, Rhizoma Chuanxiong 90～360g are subsequent use;
B. get Semen Crotonis Pulveratum, the Moschus pulverize separately becomes fine powder; The Radix Aucklandiae, Lignum Aquilariae Resinatum, Fructus Aurantii, Lignum Santali Albi, Radix Et Rhizoma Rhei, Cortex Magnoliae Officinalis, Fructus Jujubae, Rhizoma Chuanxiong eight flavors are ground into fine powder; With Semen Crotonis Pulveratum, Moschus powder facing-up, mixing sieves, and is subsequent use;
Perhaps above ten flavor medicines, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is subsequent use; The Radix Aucklandiae, Lignum Aquilariae Resinatum, Lignum Santali Albi, Fructus Aurantii, Cortex Magnoliae Officinalis, Rhizoma Chuanxiong, Radix Et Rhizoma Rhei are pulverized CO 2Supercritical extraction; Get extract, add an amount of anhydrous alcohol solution, carry out enclose with an amount of β-CD, drying promptly gets clathrate, and is subsequent use; With the medicinal residues ethanol extraction secondary behind the above-mentioned supercritical extraction, merge secondary filtrating, reclaim ethanol and concentrate subsequent use; Get Fructus Jujubae decocte with water secondary, filter; Merging filtrate concentrates, and with above-mentioned alcohol extract condensed cream mixing, drying is ground into fine powder, with clathrate, Semen Crotonis Pulveratum, Moschus mixing, sieves again, and is subsequent use;
Perhaps above ten flavor medicines, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is subsequent use; Six-element medicated powder such as Lignum Aquilariae Resinatum, the Radix Aucklandiae, Lignum Santali Albi, Fructus Aurantii, Cortex Magnoliae Officinalis, Rhizoma Chuanxiong are broken into coarse powder, add water, soak, and decocting boils distillation, collect volatile oil, and are behind β-CDBao He, subsequent use; Decocting liquid filters, and filtrating concentrates subsequent use, and medicinal residues and Radix Et Rhizoma Rhei coarse powder add alcohol reflux 2 times, filters; Merge secondary filtrating, concentrate, drying, subsequent use; Get Fructus Jujubae, add decocting and boil secondary, filter; Merge secondary filtrating, concentrate, drying, the above-mentioned fine powder that is dried and crushed into, with clathrate, Semen Crotonis Pulveratum, Moschus mixing, subsequent use;
Perhaps get the Radix Aucklandiae, Lignum Aquilariae Resinatum, Lignum Santali Albi, Fructus Aurantii, Cortex Magnoliae Officinalis, Rhizoma Chuanxiong, Radix Et Rhizoma Rhei powder and be broken into coarse powder, add alcohol reflux, filter; Merging filtrate, subsequent use; The concentrating under reduced pressure alcohol extract concentrates subsequent use; Get Fructus Jujubae, add decocting and boil, filter, concentrating under reduced pressure Fructus Jujubae water extract, the simmer down to clear paste, subsequent use; With above-mentioned gained clear paste drying under reduced pressure, getting dry extract is ground into fine powder and Semen Crotonis Pulveratum, Moschus mixing, sieves, subsequent use;
Perhaps above ten flavors, Semen Crotonis Pulveratum, Moschus pulverize separately become fine powder; All the other eight flavor medicine decocte with water 1～3 time, each 1～3 hour, collecting decoction filtered, and is condensed into thick paste; In above-mentioned thick paste, add Semen Crotonis Pulveratum, Moschus powder, mixing, subsequent use;
Get an amount of carbomer, add water and stir, NaOH regulates pH value, adds said mixture and grinds evenly, promptly gets.
2. treat the method for preparing of the Chinese medicine gel of gastrointestinal disease according to claim 1, it is characterized in that step is following:
A. take off column weight amount proportioning crude drug: the Radix Aucklandiae 250～400g, Lignum Aquilariae Resinatum 250～400g, Fructus Aurantii 250～400g, Lignum Santali Albi 150～250g, Radix Et Rhizoma Rhei 150～250g, Cortex Magnoliae Officinalis 250～400g, Moschus 6～12g, Semen Crotonis Pulveratum 100～150g, Fructus Jujubae 800～1200g, Rhizoma Chuanxiong 150～250g are subsequent use;
B. get Semen Crotonis Pulveratum, the Moschus pulverize separately becomes fine powder; The Radix Aucklandiae, Lignum Aquilariae Resinatum, Fructus Aurantii, Lignum Santali Albi, Radix Et Rhizoma Rhei, Cortex Magnoliae Officinalis, Fructus Jujubae, Rhizoma Chuanxiong eight flavors are ground into fine powder; With Semen Crotonis Pulveratum, Moschus powder facing-up, mixing sieves, and is subsequent use;
Perhaps above ten flavor medicines, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is subsequent use; Lignum Aquilariae Resinatum, the Radix Aucklandiae, Lignum Santali Albi, Fructus Aurantii, Cortex Magnoliae Officinalis, Rhizoma Chuanxiong, Radix Et Rhizoma Rhei powder are broken into 40-80 purpose powder, CO 2Supercritical extraction, extracting pressure 5-40MPa, temperature 35-60 ℃, CO 2Flow velocity 20-35L/h, extraction 2-5h; Get extract, add an amount of anhydrous alcohol solution,, adopt polishing to carry out enclose,, promptly get clathrate in 40 ℃ of vacuum dryings with an amount of β-CD, subsequent use; Medicinal residues behind the above-mentioned supercritical extraction are added 60% ethanol extraction secondary, merge secondary filtrating, relative density is that 1.25-1.30 is subsequent use when reclaiming ethanol to 60 ℃; Get Fructus Jujubae decocte with water secondary, each 2h filters; Merging filtrate, relative density 1.25-1.30 when being concentrated into 60 ℃, with above-mentioned alcohol extract condensed cream mixing, drying is ground into fine powder, again with clathrate, Semen Crotonis Pulveratum, Moschus mixing, crosses 80 mesh sieves, and is subsequent use;
Perhaps above ten flavor medicines, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is subsequent use; Six-element medicated powder such as Lignum Aquilariae Resinatum, the Radix Aucklandiae, Lignum Santali Albi, Fructus Aurantii, Cortex Magnoliae Officinalis, Rhizoma Chuanxiong are broken into coarse powder, add 16 times of water gagings, soak 4 hours, and decocting boils distillation 8h altogether, collects volatile oil, and is behind β-CDBao He, subsequent use; Decocting liquid filters, and relative density 1.25-1.30 was subsequent use when filtrating was concentrated into 60 ℃, and medicinal residues and Radix Et Rhizoma Rhei coarse powder add 70% alcohol reflux 2 times, for the first time 2h; 1h filters for the second time; Merge secondary filtrating, relative density 1.20-1.25 when being concentrated into 60 ℃, drying, subsequent use; Get Fructus Jujubae, add decocting and boil secondary, each 2h filters; Merge secondary filtrating, relative density 1.28-1.32 when being concentrated into 60 ℃, drying, with the above-mentioned fine powder that is dried and crushed into,, subsequent use with clathrate, Semen Crotonis Pulveratum, Moschus mixing;
Perhaps get the Radix Aucklandiae, Lignum Aquilariae Resinatum, Lignum Santali Albi, Fructus Aurantii, Cortex Magnoliae Officinalis, Rhizoma Chuanxiong, Radix Et Rhizoma Rhei powder and be broken into coarse powder, add 80% alcohol reflux 2 times, 8 times of amounts of alcohol adding amount for the first time, backflow 2h; 6 times of amounts of the alcohol adding amount second time, backflow 1h filters; Merge secondary filtrating, subsequent use; Relative density 1.25-1.30 is subsequent use when concentrating under reduced pressure alcohol extract, 60 ℃ of 60-65 ℃ of simmer down tos; Get Fructus Jujubae, add decocting and boil secondary, add 10 times of amounts of water, backflow 2h for the first time; For the second time add 8 times of amounts of water, backflow 1h filters, and merges secondary filtrating, and is subsequent use; Concentrating under reduced pressure Fructus Jujubae water extract, the clear paste of relative density 1.28-1.32 is subsequent use when 60 ℃ of 80-85 ℃ of following simmer down tos; With above-mentioned gained clear paste drying under reduced pressure, getting dry extract is ground into fine powder and Semen Crotonis Pulveratum, Moschus mixing, crosses 80 mesh sieves, subsequent use;
Perhaps above ten flavors, Semen Crotonis Pulveratum, Moschus pulverize separately become fine powder; Eight flavor medicine decocte with water such as all the other Radix Aucklandiae, Lignum Aquilariae Resinatum 2 times, each 2 hours, collecting decoction filtered, and is condensed into thick paste, in above-mentioned thick paste, adds Semen Crotonis Pulveratum, Moschus powder, and mixing is subsequent use;
Get carbomer 80～200g, add water 5000～20000g and stir, NaOH regulates pH value, adds said mixture 1000～3500g, grinds evenly, promptly gets.
3. like the method for preparing of the Chinese medicine gel of the said treatment gastrointestinal disease of claim 2, it is characterized in that comprising the steps:
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 300g, Lignum Aquilariae Resinatum 300g, Fructus Aurantii 300g, Lignum Santali Albi 180g, Radix Et Rhizoma Rhei 180g, Cortex Magnoliae Officinalis 300g, Moschus 9g, Semen Crotonis Pulveratum 120g, Fructus Jujubae 1000g, Rhizoma Chuanxiong 180g are subsequent use;
B. get Semen Crotonis Pulveratum, the Moschus pulverize separately becomes fine powder; The Radix Aucklandiae, Lignum Aquilariae Resinatum, Fructus Aurantii, Lignum Santali Albi, Radix Et Rhizoma Rhei, Cortex Magnoliae Officinalis, Fructus Jujubae, Rhizoma Chuanxiong eight flavors are ground into fine powder; With Semen Crotonis Pulveratum, Moschus powder facing-up, mixing sieves, and is subsequent use;
Perhaps above ten flavor medicines, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is subsequent use; Lignum Aquilariae Resinatum, the Radix Aucklandiae, Lignum Santali Albi, Fructus Aurantii, Cortex Magnoliae Officinalis, Rhizoma Chuanxiong, Radix Et Rhizoma Rhei powder are broken into 40-80 purpose powder, CO 2Supercritical extraction, extracting pressure 5-40MPa, temperature 35-60 ℃, CO 2Flow velocity 20-35L/h, extraction 2-5h; Get extract, add an amount of anhydrous alcohol solution,, adopt polishing to carry out enclose,, promptly get clathrate in 40 ℃ of vacuum dryings with an amount of β-CD, subsequent use; Medicinal residues behind the above-mentioned supercritical extraction are added 60% ethanol extraction secondary, merge secondary filtrating, relative density is that 1.25-1.30 is subsequent use when reclaiming ethanol to 60 ℃; Get Fructus Jujubae decocte with water secondary, each 2h filters; Merging filtrate, relative density 1.25-1.30 when being concentrated into 60 ℃, with above-mentioned alcohol extract condensed cream mixing, drying is ground into fine powder, again with clathrate, Semen Crotonis Pulveratum, Moschus mixing, crosses 80 mesh sieves, and is subsequent use;
Perhaps above ten flavor medicines, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is subsequent use; Six-element medicated powder such as Lignum Aquilariae Resinatum, the Radix Aucklandiae, Lignum Santali Albi, Fructus Aurantii, Cortex Magnoliae Officinalis, Rhizoma Chuanxiong are broken into coarse powder, add 16 times of water gagings, soak 4 hours, and decocting boils distillation 8h altogether, collects volatile oil, and is behind β-CDBao He, subsequent use; Decocting liquid filters, and relative density 1.25-1.30 was subsequent use when filtrating was concentrated into 60 ℃, and medicinal residues and Radix Et Rhizoma Rhei coarse powder add 70% alcohol reflux 2 times, for the first time 2h; 1h filters for the second time; Merge secondary filtrating, relative density 1.20-1.25 when being concentrated into 60 ℃, drying, subsequent use; Get Fructus Jujubae, add decocting and boil secondary, each 2h filters; Merge secondary filtrating, relative density 1.28-1.32 when being concentrated into 60 ℃, drying, with the above-mentioned fine powder that is dried and crushed into,, subsequent use with clathrate, Semen Crotonis Pulveratum, Moschus mixing;
Perhaps get the Radix Aucklandiae, Lignum Aquilariae Resinatum, Lignum Santali Albi, Fructus Aurantii, Cortex Magnoliae Officinalis, Rhizoma Chuanxiong, Radix Et Rhizoma Rhei powder and be broken into coarse powder, add 80% alcohol reflux 2 times, 8 times of amounts of alcohol adding amount for the first time, backflow 2h; 6 times of amounts of the alcohol adding amount second time, backflow 1h filters; Merge secondary filtrating, subsequent use; Relative density 1.25-1.30 is subsequent use when concentrating under reduced pressure alcohol extract, 60 ℃ of 60-65 ℃ of simmer down tos; Get Fructus Jujubae, add decocting and boil secondary, add 10 times of amounts of water, backflow 2h for the first time; For the second time add 8 times of amounts of water, backflow 1h filters, and merges secondary filtrating, and is subsequent use; Concentrating under reduced pressure Fructus Jujubae water extract, the clear paste of relative density 1.28-1.32 is subsequent use when 60 ℃ of 80-85 ℃ of following simmer down tos; With above-mentioned gained clear paste drying under reduced pressure, getting dry extract is ground into fine powder and Semen Crotonis Pulveratum, Moschus mixing, crosses 80 mesh sieves, subsequent use;
Perhaps above ten flavors, Semen Crotonis Pulveratum, Moschus pulverize separately become fine powder; Eight flavor medicine decocte with water such as all the other Radix Aucklandiae, Lignum Aquilariae Resinatum 2 times, each 2 hours, collecting decoction filtered, and is condensed into thick paste, in above-mentioned thick paste, adds Semen Crotonis Pulveratum, Moschus powder, and mixing is subsequent use;
Get carbomer 108g, add water 9000g and stir, NaOH regulates pH to 7, adds said mixture 2869g, grinds evenly, promptly gets.
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Publication number Priority date Publication date Assignee Title
CN1939477A (en) * 2006-09-27 2007-04-04 天津中新药业集团股份有限公司乐仁堂制药厂 Chinese-medicinal composition for treating enterogastric diseases

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1939477A (en) * 2006-09-27 2007-04-04 天津中新药业集团股份有限公司乐仁堂制药厂 Chinese-medicinal composition for treating enterogastric diseases

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