CN101757288A - Traditional Chinese medicine composition for treating gastrointestinal diseases and preparation method thereof - Google Patents

Traditional Chinese medicine composition for treating gastrointestinal diseases and preparation method thereof Download PDF

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Publication number
CN101757288A
CN101757288A CN200810154422A CN200810154422A CN101757288A CN 101757288 A CN101757288 A CN 101757288A CN 200810154422 A CN200810154422 A CN 200810154422A CN 200810154422 A CN200810154422 A CN 200810154422A CN 101757288 A CN101757288 A CN 101757288A
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standby
moschus
powder
semen crotonis
crotonis pulveratum
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CN101757288B (en
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陈坚
王磊
袁学海
王伟
杨瑾
王春晨
郝忻
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Jinyao Darentang Group Co ltd
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Lerentang Pharmaceutical Factory of Tianjin Zhongxin Pharmaceutical Group Co Ltd
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    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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Abstract

The invention relates to a traditional Chinese medicine composition for treating gastrointestinal diseases and a preparation method thereof. The traditional Chinese medicine composition is prepared from tens of traditional Chinese herbs of costustoot, agilawood, fructus aurantii, sanders, rheum officinale, mangnolia officinalis, muak, defatted croton seed powder, date and ligusticum wallichii. The traditional Chinese medicine composition is mainly used for treating diseases of acute diarrhea, irritable bowel syndrome and the like in clinic.

Description

A kind of treatment gastrointestinal disease Chinese medicine composition and preparation method thereof
Technical field
The present invention relates to field of medicaments, particularly relate to a kind of treatment gastrointestinal disease Chinese medicine composition and preparation method thereof.
Background technology
Diarrhoea can be divided into infectious and non-infectious two classes.Infectious diarrhea is divided into bacterial infection and viral infection again; Noninfectious diarrhea then can be caused by the change of improper diet, food anaphylaxis, rule of life, abrupt change of climate even multiple reason such as nervous.Motherland's medical science thinks to have loose bowels and is meant that defecation frequency increases, feces is rare clearly, even as water sample.The major lesions of having loose bowels is taste and intestine and small intestine.Its pathogenesis has being invaded by exogenous pathogen, injury due to diet, seven emotions discord, damp internal resistance and internal organs weakness etc.The clinical findings damp is caused a disease cold-damp and damp and hot branch.The spleen and stomach function obstacle is to be caused by multiple factor, has exopathogen influence, taste weakness itself, incoordination between the liver and spleen and gastrointestinal function deficiency etc. all can cause spleen and stomach function not normal and have loose bowels.Survey data shows that diarrhoea sickness rate in urban population reaches 0.4 time/people, and the rural population sickness rate reaches 0.5 time/people.Though diarrhoea is minor illness, pathogenic factor also is diversified, and changes with epoch, environment.We can say that the diarrhoea of today and the diarrhoea before 20 years have had the change of essence from pathogeny.Along with development of times, people's living standard attains the well-off standard substantially, and sanitary condition is improved greatly, fewer and feweri by the diarrhoea ratio that bacterial infection causes, on the contrary, because rhythm of life is accelerated, the functional diarrhea ratio that struggle for existence fierceness, pressure cause greatly obviously rises.One studies show that, the diarrhoeal diseases people of China about 30% needs antibiosis usually to treat, and 70% does not need should not use antibiotic therapy yet.Consumer also more and more notices the untoward reaction of products such as berberine, norfloxacin, and the harm that abuse of antibiotics brought.Diarrhoea market is except low side antibiotic products such as berberine, norfloxacin, some non-antibiotic products have also been introduced in recent years, such as dioctahedral smectite, Birid Triple Viable etc., but be positioned at high-end consumer groups, for most of consumer groups, its price positioning does not conform to the consumption location of such minor illness of suffering from diarrhoea with consumer.Analysis expert thinks, mainly is based on viral in urban market diarrhoea, and based on bacterial infection, if according to the principle of the market segments, at present a lot of products all are difficult to cover the whole market in the rural area.For alteration of intestinal flora person, available little ecological active bacteria formulation provides probiotics, improves intestinal environment, improves intestinal absorption, kinestate.As: bifidobacteria viable bacteria preparation (the happy capsule of beautiful pearl intestinal), Birid Triple Viable capsule, bacillus cicheniformis (whole intestinal rubber capsule); The intestinal mucosa protective agent: two eight body Montmorillonitums (dioctahedral smectite), the protection intestinal mucosa can suppress fixedly mycin, promotes the intestinal mucosal lesion reparation; Contain the creosote component preparation: the excessive secretion that can suppress intestinal juice.
At present gastrointestinal disease treating pill on the market is mainly used in treatment diarrhoea, enteritis, and bacillary dysentery, distension and fullness in the abdomen, stomachache, the food stagnation infantile dyspepsia, its pharmacological action is higher than like product: diarrhea, antibiotic, antiviral, four kinds of functions of adjusting gastrointestinal function are also deposited.But contain Cinnabaris in its prescription, its effect is a tranquillizing the mind by relieving convulsion, but contain hydrargyrum in the Cinnabaris, hydrargyrum is very big to the harm of human body, it is the process of a subtle lasting absorption, and human body contacts hydrargyrum for a long time can cause chronic poisoning: nerve, digestion, hormonal system and kidney to the people produce harm; Neurasthenic crowd may cause symptoms such as headache, dizziness, insomnia, hypomnesis, malaise; And anemia of pregnant woman and the women of age of sucking contact hydrargyrum for a long time, also may endanger fetus and baby's health.Mercurous in addition medicine has been subjected to certain restriction when exporting other countries, require mercury content to require then strict more for some European countries less than 0.5ppm as Singapore.
Summary of the invention
The purpose of this invention is to provide a kind of treatment gastrointestinal disease Chinese medicine composition.
Another object of the present invention provides a kind of preparation method for the treatment of the gastrointestinal disease Chinese medicine composition.
It is to be made by Flos Caryophylli, the Radix Aucklandiae or Lignum Aquilariae Resinatum, Fructus Aurantii, Lignum Santali Albi, Radix Et Rhizoma Rhei, Cortex Magnoliae Officinalis, Moschus, Semen Crotonis Pulveratum, Fructus Jujubae, Rhizoma Chuanxiong ten flavor flavour of a drug that the present invention treats the gastrointestinal disease Chinese medicine composition.
The present invention treats the gastrointestinal disease Chinese medicine composition, be to adopt following materials of weight proportions to make: Flos Caryophylli 50～200g, the Radix Aucklandiae or Lignum Aquilariae Resinatum 150～600g, Fructus Aurantii 150～600g, Lignum Santali Albi 90～360g, Radix Et Rhizoma Rhei 90～360g, Cortex Magnoliae Officinalis 150～600g, Moschus 4.5～18g, Semen Crotonis Pulveratum 60～240g, Fructus Jujubae 500～2000g and Rhizoma Chuanxiong 90～360g.
The present invention preferably treats the gastrointestinal disease Chinese medicine composition, be to adopt following materials of weight proportions to make: Flos Caryophylli 80～150g, the Radix Aucklandiae or Lignum Aquilariae Resinatum 250～400g, Fructus Aurantii 200～400g, Lignum Santali Albi 150～250g, Radix Et Rhizoma Rhei 150～250g, Cortex Magnoliae Officinalis 250～400g, Moschus 6～12g, Semen Crotonis Pulveratum 100～150g, Fructus Jujubae 800～1200g and Rhizoma Chuanxiong 150～250g.
The further preferred treatment gastrointestinal disease of the present invention Chinese medicine composition is to adopt following materials of weight proportions to make: Flos Caryophylli 100g, the Radix Aucklandiae or Lignum Aquilariae Resinatum 300g, Fructus Aurantii 300g, Lignum Santali Albi 180g, Radix Et Rhizoma Rhei 180g, Cortex Magnoliae Officinalis 300g, Moschus 9g, Semen Crotonis Pulveratum 120g, Fructus Jujubae 1000g and Rhizoma Chuanxiong 180g.
The present invention treats the gastrointestinal disease Chinese medicine composition, can adopt following method to prepare active component for crude drug: as one or several use in conjunction preparations in extraction, water extraction, decoction and alcohol sedimentation technique, infusion process, percolation, reflux extraction, continuous backflow extraction method, the macroreticular resin absorbing method.But in order to make each crude drug of this medicine bring into play drug effect better, the present invention preferably adopts following technology to extract active component to raw material, and makes the present invention and treat the gastrointestinal disease Chinese medicine composition, but this can not limit protection scope of the present invention.
The present invention treats the gastrointestinal disease Chinese medicine composition, and employing is prepared as follows method and makes:
A. take off and state the weight proportion crude drug: Flos Caryophylli, the Radix Aucklandiae or Lignum Aquilariae Resinatum, Fructus Aurantii, Lignum Santali Albi, Radix Et Rhizoma Rhei, Cortex Magnoliae Officinalis, Moschus, Semen Crotonis Pulveratum, Fructus Jujubae and Rhizoma Chuanxiong are standby;
B. above ten flavor medicines, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is standby; Flos Caryophylli, the Radix Aucklandiae or Lignum Aquilariae Resinatum, Lignum Santali Albi, Fructus Aurantii, Cortex Magnoliae Officinalis, Rhizoma Chuanxiong, Radix Et Rhizoma Rhei are pulverized CO 2Supercritical extraction; Get extract, add an amount of anhydrous alcohol solution, carry out enclose with an amount of β-CD, drying promptly gets clathrate, and is standby; With the medicinal residues ethanol extraction secondary behind the above-mentioned supercritical extraction, merge secondary filtrate, reclaim ethanol and concentrate standby; Get Fructus Jujubae and decoct with water secondary, filter; Merging filtrate concentrates, and with above-mentioned alcohol extract condensed cream mixing, drying is ground into fine powder, with clathrate, Semen Crotonis Pulveratum, the Moschus mixing that sieves, sieves again, and is standby;
Perhaps above ten flavor medicines, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is standby; Six-element medicated powder such as Flos Caryophylli, the Radix Aucklandiae or Lignum Aquilariae Resinatum, Lignum Santali Albi, Fructus Aurantii, Cortex Magnoliae Officinalis, Rhizoma Chuanxiong are broken into coarse powder, add water, soak, and decocting boils distillation, collect volatile oil, and are with after β-CD inclusion, standby; Decocting liquid filters, and filtrate concentrates standby, and medicinal residues and Radix Et Rhizoma Rhei coarse powder add alcohol reflux 2 times, filters; Merge secondary filtrate, concentrate, drying, standby; Get Fructus Jujubae, add decocting and boil secondary, filter; Merge secondary filtrate, concentrate, drying, with the above-mentioned fine powder that is dried and crushed into,, standby with Semen Crotonis Pulveratum, Moschus mixing;
Perhaps above ten flavors, Semen Crotonis Pulveratum, Moschus pulverize separately become fine powder; All the other eight flavor medicines decoct with water 1～3 time, and each 1～3 hour, collecting decoction filtered, and is condensed into thick paste; In above-mentioned thick paste, add Semen Crotonis Pulveratum, Moschus powder, mixing, standby;
Perhaps above ten flavors, Semen Crotonis Pulveratum, Moschus pulverize separately become fine powder; All the other eight flavors are ground into fine powder, and with Semen Crotonis Pulveratum, Moschus powder facing-up, mixing sieves, and is standby;
C. the active component that step b is obtained is made preparation.
The present invention preferably treats the gastrointestinal disease Chinese medicine composition, and employing is prepared as follows method and makes:
A. take off and state the weight proportion crude drug: Flos Caryophylli, the Radix Aucklandiae or Lignum Aquilariae Resinatum, Fructus Aurantii, Lignum Santali Albi, Radix Et Rhizoma Rhei, Cortex Magnoliae Officinalis, Moschus, Semen Crotonis Pulveratum, Fructus Jujubae and Rhizoma Chuanxiong are standby;
B. above ten flavor medicines, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is standby; Flos Caryophylli, the Radix Aucklandiae or Lignum Aquilariae Resinatum, Lignum Santali Albi, Fructus Aurantii, Cortex Magnoliae Officinalis, Rhizoma Chuanxiong, Radix Et Rhizoma Rhei powder are broken into 40-80 purpose powder, CO 2Supercritical extraction, extracting pressure 5-40MPa, temperature 35-60 ℃, CO 2Flow velocity 20-35L/h, extraction 2-5h; Get extract, add an amount of anhydrous alcohol solution,, adopt polishing to carry out enclose,, promptly get clathrate in 40 ℃ of vacuum dryings with an amount of β-CD, standby; Medicinal residues behind the above-mentioned supercritical extraction are added 60% ethanol extraction secondary, merge secondary filtrate, relative density is that 1.25-1.30 is standby when reclaiming ethanol to 60 ℃; Get Fructus Jujubae and decoct with water secondary, each 2h filters; Merging filtrate, relative density 1.25-1.30 when being concentrated into 60 ℃, with above-mentioned alcohol extract condensed cream mixing, drying is ground into fine powder, with clathrate, Semen Crotonis Pulveratum, the Moschus mixing that sieves, crosses 80 mesh sieves again, and is standby;
Perhaps above ten flavor medicines, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is standby; Six-element medicated powder such as Flos Caryophylli, the Radix Aucklandiae or Lignum Aquilariae Resinatum, Lignum Santali Albi, Fructus Aurantii, Cortex Magnoliae Officinalis, Rhizoma Chuanxiong are broken into coarse powder, add 16 times of water gagings, soak 4 hours, and decocting boils distillation 8h altogether, collects volatile oil, and is with after β-CD inclusion, standby; Decocting liquid filters, and relative density 1.25-1.30 was standby when filtrate was concentrated into 60 ℃, and medicinal residues and Radix Et Rhizoma Rhei coarse powder add 70% alcohol reflux 2 times, for the first time 2h; 1h filters for the second time; Merge secondary filtrate, relative density 1.20-1.25 when being concentrated into 60 ℃, drying, standby; Get Fructus Jujubae, add decocting and boil secondary, each 2h filters; Merge secondary filtrate, relative density 1.28-1.32 when being concentrated into 60 ℃, drying, with the above-mentioned fine powder that is dried and crushed into,, standby with Semen Crotonis Pulveratum, Moschus mixing;
Perhaps above ten flavors, Semen Crotonis Pulveratum, Moschus pulverize separately become fine powder; All the other eight flavor medicines decoct with water 2 times, and each 2 hours, collecting decoction filtered, and is condensed into thick paste; In above-mentioned thick paste, add Semen Crotonis Pulveratum, Moschus powder, mixing, standby;
Perhaps above ten flavors, Semen Crotonis Pulveratum, Moschus pulverize separately become fine powder; All the other eight flavors are ground into fine powder, and with Semen Crotonis Pulveratum, Moschus powder facing-up, mixing sieves, and is standby;
C. the active component that step b is obtained is made preparation.
A kind of preparation method for the treatment of the gastrointestinal disease Chinese medicine composition, step is as follows:
A. get the weight proportion crude drug: Flos Caryophylli, the Radix Aucklandiae or Lignum Aquilariae Resinatum, Fructus Aurantii, Lignum Santali Albi, Radix Et Rhizoma Rhei, Cortex Magnoliae Officinalis, Moschus, Semen Crotonis Pulveratum, Fructus Jujubae and Rhizoma Chuanxiong are standby;
B. above ten flavor medicines, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is standby; Flos Caryophylli, the Radix Aucklandiae or Lignum Aquilariae Resinatum, Lignum Santali Albi, Fructus Aurantii, Cortex Magnoliae Officinalis, Rhizoma Chuanxiong, Radix Et Rhizoma Rhei are pulverized CO 2Supercritical extraction; Get extract, add an amount of anhydrous alcohol solution, carry out enclose with an amount of β-CD, drying promptly gets clathrate, and is standby; With the medicinal residues ethanol extraction secondary behind the above-mentioned supercritical extraction, merge secondary filtrate, reclaim ethanol and concentrate standby; Get Fructus Jujubae and decoct with water secondary, filter; Merging filtrate concentrates, and with above-mentioned alcohol extract condensed cream mixing, drying is ground into fine powder, with clathrate, Semen Crotonis Pulveratum, the Moschus mixing that sieves, sieves again, and is standby;
Perhaps above ten flavor medicines, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is standby; Six-element medicated powder such as Flos Caryophylli, the Radix Aucklandiae or Lignum Aquilariae Resinatum, Lignum Santali Albi, Fructus Aurantii, Cortex Magnoliae Officinalis, Rhizoma Chuanxiong are broken into coarse powder, add water, soak, and decocting boils distillation, collect volatile oil, and are with after β-CD inclusion, standby; Decocting liquid filters, and filtrate concentrates standby, and medicinal residues and Radix Et Rhizoma Rhei coarse powder add alcohol reflux 2 times, filters; Merge secondary filtrate, concentrate, drying, standby; Get Fructus Jujubae, add decocting and boil secondary, filter; Merge secondary filtrate, concentrate, drying, with the above-mentioned fine powder that is dried and crushed into,, standby with Semen Crotonis Pulveratum, Moschus mixing;
Perhaps above ten flavors, Semen Crotonis Pulveratum, Moschus pulverize separately become fine powder; All the other eight flavor medicines decoct with water 1～3 time, and each 1～3 hour, collecting decoction filtered, and is condensed into thick paste; In above-mentioned thick paste, add Semen Crotonis Pulveratum, Moschus powder, mixing, standby;
Perhaps above ten flavors, Semen Crotonis Pulveratum, Moschus pulverize separately become fine powder; All the other eight flavors are ground into fine powder, and with Semen Crotonis Pulveratum, Moschus powder facing-up, mixing sieves, and is standby;
C. the active component that step b is obtained is made preparation.
The present invention preferably treats the preparation method of gastrointestinal disease Chinese medicine composition, and step is as follows:
A. take off and state the weight proportion crude drug: Flos Caryophylli, the Radix Aucklandiae or Lignum Aquilariae Resinatum, Fructus Aurantii, Lignum Santali Albi, Radix Et Rhizoma Rhei, Cortex Magnoliae Officinalis, Moschus, Semen Crotonis Pulveratum, Fructus Jujubae and Rhizoma Chuanxiong are standby;
B. above ten flavor medicines, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is standby; Flos Caryophylli, the Radix Aucklandiae or Lignum Aquilariae Resinatum, Lignum Santali Albi, Fructus Aurantii, Cortex Magnoliae Officinalis, Rhizoma Chuanxiong, Radix Et Rhizoma Rhei powder are broken into 40-80 purpose powder, CO 2Supercritical extraction, extracting pressure 5-40MPa, temperature 35-60 ℃, CO 2Flow velocity 20-35L/h, extraction 2-5h; Get extract, add an amount of anhydrous alcohol solution,, adopt polishing to carry out enclose,, promptly get clathrate in 40 ℃ of vacuum dryings with an amount of β-CD, standby; Medicinal residues behind the above-mentioned supercritical extraction are added 60% ethanol extraction secondary, merge secondary filtrate, relative density is that 1.25-1.30 is standby when reclaiming ethanol to 60 ℃; Get Fructus Jujubae and decoct with water secondary, each 2h filters; Merging filtrate, relative density 1.25-1.30 when being concentrated into 60 ℃, with above-mentioned alcohol extract condensed cream mixing, drying is ground into fine powder, with clathrate, Semen Crotonis Pulveratum, the Moschus mixing that sieves, crosses 80 mesh sieves again, and is standby;
Perhaps above ten flavor medicines, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is standby; Six-element medicated powder such as Flos Caryophylli, the Radix Aucklandiae or Lignum Aquilariae Resinatum, Lignum Santali Albi, Fructus Aurantii, Cortex Magnoliae Officinalis, Rhizoma Chuanxiong are broken into coarse powder, add 16 times of water gagings, soak 4 hours, and decocting boils distillation 8h altogether, collects volatile oil, and is with after β-CD inclusion, standby; Decocting liquid filters, and relative density 1.25-1.30 was standby when filtrate was concentrated into 60 ℃, and medicinal residues and Radix Et Rhizoma Rhei coarse powder add 70% alcohol reflux 2 times, for the first time 2h; 1h filters for the second time; Merge secondary filtrate, relative density 1.20-1.25 when being concentrated into 60 ℃, drying, standby; Get Fructus Jujubae, add decocting and boil secondary, each 2h filters; Merge secondary filtrate, relative density 1.28-1.32 when being concentrated into 60 ℃, drying, with the above-mentioned fine powder that is dried and crushed into,, standby with Semen Crotonis Pulveratum, Moschus mixing;
Perhaps above ten flavors, Semen Crotonis Pulveratum, Moschus pulverize separately become fine powder; All the other eight flavor medicines decoct with water 2 times, and each 2 hours, collecting decoction filtered, and is condensed into thick paste; In above-mentioned thick paste, add Semen Crotonis Pulveratum, Moschus powder, mixing, standby;
Perhaps above ten flavors, Semen Crotonis Pulveratum, Moschus pulverize separately become fine powder; All the other eight flavors are ground into fine powder, and with Semen Crotonis Pulveratum, Moschus powder facing-up, mixing sieves, and is standby;
C. the active component that step b is obtained is made preparation.
Fructus Aurantii among the present invention is a stir-baked Fructus Aurantii in bran; Cortex Magnoliae Officinalis is a Cortex Magnoliae Officinalis (processed with ginger); Fructus Jujubae is that Fructus Jujubae, the Moschus of enucleation is the artificial Moschus.
The present invention treats the application of gastrointestinal disease Chinese medicine composition in preparation treatment irritable bowel syndrome medicine.
The present invention treat the gastrointestinal disease Chinese medicine composition at preparation treatment diarrhoea, poor appetite, feel sick, the application in the vomiting, abdominal distention, stomachache, dyspepsia, dysentery, enteritis, functional gastrointestinal disease medicine.
More than form when producing and to increase or to reduce according to corresponding ratio, as large-scale production can be unit with kilogram or with the ton, small-scale production can be unit with the gram also, and weight can increase or reduce, but the crude drug material weight proportion constant rate between each composition.
In order to understand the present invention better, further set forth the beneficial effect of medicine of the present invention below by Drug therapy chronic gastrointestinal disease 100 routine clinical verification case summaries of the present invention.Below used medicine of the present invention prepares according to embodiment 16 methods in the test.
One, observational technique
(1) object of observation: this group case is the out-patient, and untreated or treatment be person more, comprises functional diarrhea, functional dyspepsia, and irritable bowel syndrome, chronic and infective diarrhea is the object of observation.
(2) diagnostic criteria
Adopt " Rome II standard in 1999 ", selected case meets the diagnostic criteria of functional diarrhea, functional dyspepsia, irritable bowel syndrome, chronic and infective diarrhea.All cases are got rid of stomach, duodenum, colon organic disease all through stomach, colon scope or X line barium examination.
(3) rejecting standard
1, organic digestive system disease person is arranged, as polyp, tumor etc.
2, Liver and kidney is arranged, endocrine, the serious protopathy person of immune system and blood system: diabetes, uremia, hepatopathy etc.
3, anemia of pregnant woman and women breast-feeding their children.
4, do not meet diagnostic criteria.
(4) symptom degree evaluation standard
With reference to " new Chinese medicine clinical guidance principle ": according to symptom light, in, severe remembers 1,2,3 fen respectively.
1, symptom scoring method:
(1) asymptomatic (-): remember 0 fen;
(2) slight (+): occur note 1 minute once in a while;
(3) moderate (++): note 2 minutes often occur;
(4) severe (+++): continue to exist note 3 minutes.
2, have loose bowels:
(1) the asymptomatic and soft change (-) that is shaped: every day, 1-2 note was 0 minute;
(2) slight (+): symptom is slight, does not influence live and work, can stand, and stool every day 2-3 time, mushy stool or Mucous Stool are remembered 1 fen;
(3) moderate (++): symptom is heavier, has influenced work, life, still can stand, and stool is the egg style, every day 4-5 time, or the Mucous Stool moderate is remembered 2 fens;
(4) severe (+++): serious symptom, hinder one's work and live, be difficult to stand, rare watery stool, every day is more than 6 times, or a large amount of notes of Mucous Stool 3 minutes.
3, the deciding degree standard of disease
(1) severe: the cardinal symptom integration=＞total mark 70%;
(2) moderate: 70% of 30%＜=cardinal symptom integration＜total mark;
(3) slight: 30% of cardinal symptom integration＜=total mark;
(5) curative effect determinate standard and statistical method
Reference " new Chinese medicine clinical guidance principle " is as standard.
1, curative effect determinate standard:
(1) cure: cardinal symptom disappears, and stool is shaped, and every day 1-2 time, therapeutic index is 100%;
(2) produce effects: main clinic symptoms disappears substantially, times of defecation every day 2-3 time, 75%＜=therapeutic index＜100%;
(3) effective: main clinic symptoms takes a turn for the better, and stool shape and time number average take a favorable turn 30%＜=therapeutic index＜75%;
(4) invalid: main clinic symptoms does not have change, therapeutic index＜30%;
The total score value of cardinal symptom * 100% before curative effect of disease index=(the total score value of cardinal symptom before the treatment-total score value of treatment back cardinal symptom)/treatment.
2, individual event symptom therapeutic evaluation standard:
(1) cure: after finishing the course of treatment, transference cure;
(2) produce effects: after curative effect finished, the symptom classification reduced 2 grades;
(3) effective: after curative effect finished, the symptom classification reduced 1 grade;
(4) invalid: as not reach above-mentioned standard.
(6) observation index
1, health giving quality is observed:
(1) before the treatment, the variation of sings and symptoms in the course of treatment.
(2) every day times of defecation, amount.
(3) stool shape is just wait as bloody purulent stool, Mucous Stool and rare water.
(4) stool routine examination inspection: erythrocyte, leukocyte and pus cell quantity in the stool have or not indigestion dietary fiber, fat drop etc.
(5) the part patient does just and cultivates.
(6) the part patient does colonoscope, intestinal radiography, gastroscope.
3, safety is observed:
(1) blood, routine urianlysis.
(2) just routine test.
4, main clinic symptoms is observed:
(1) functional diarrhea: diarrhoea, with tenesmus, watery stool, Mucous Stool.
(2) functional dyspepsia: upper abdomen is glutted, morning is full, belch, Upper abdominal pain, nausea and vomiting, acid regurgitation.
(3) irritable bowel syndrome: stomachache, abdominal distention, diarrhoea, just not to the utmost, times of defecation, shape.
(4) chronic and infective diarrhea: diarrhoea, stomachache, tenesmus, the dense hemafecia of mucus.
Two, clinical data
Therapeutic Method
All the cases other treatment medicine of stopping using during medication uses medicine of the present invention merely, usage and dosage be 3 profits/time, 3 times/day, be 4 weeks the course of treatment.
Statistical method
Enumeration data is used X 2Check, measurement data are used the t check.
Observed result
1, each sick clinical treatment front and back total effects of planting is observed, and is as shown in table 1
Each sick clinical treatment front and back total effects table of planting of table 1
Figure G2008101544229D0000081
2, each sick clinical treatment front and back obvious effective rate comparable situation of planting is as shown in table 2
Each sick clinical treatment front and back obvious effective rate comparison sheet of planting of table 2
Figure G2008101544229D0000082
Four kinds of sick X 2Relatively, P＞0.05 not statistically significant illustrates that this medicine all has significant therapeutic effect to above-mentioned 4 kinds of diseases.
Three, the result shows
1, various chronic gastrointestinal disease had the good curing effect
Clinical effectiveness shows that the sick statistical effect of planting of each of Drug therapy chronic gastrointestinal disease of the present invention is learned there was no significant difference, and illustrating all has good therapeutical effect to various chronic gastrointestinal disease.
2, has the obvious effect that improves chronic gastrointestinal disease patient clinical symptoms
Clinical effectiveness shows that medicine of the present invention can obviously be alleviated clinical symptoms.To single sick plant primary symptom to improve effect obvious, total effective rate is all more than 85%.
3, do not find apparent side effect during the medication.
The specific embodiment
Further set forth the preparation method of medicine of the present invention by the following examples.
Embodiment 1
A. take off column weight amount proportioning crude drug: Flos Caryophylli 150g, Lignum Aquilariae Resinatum 150g, Fructus Aurantii 150g, Lignum Santali Albi 90g, Radix Et Rhizoma Rhei 90g, Cortex Magnoliae Officinalis 150g, artificial Moschus 4.5g, Semen Crotonis Pulveratum 60g, Fructus Jujubae 500g, Rhizoma Chuanxiong 90g are standby;
B. above ten flavor medicines, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is standby; Flos Caryophylli, Lignum Aquilariae Resinatum, Lignum Santali Albi, Fructus Aurantii, Cortex Magnoliae Officinalis, Rhizoma Chuanxiong, Radix Et Rhizoma Rhei are pulverized CO 2Supercritical extraction; Get extract, add an amount of anhydrous alcohol solution, carry out enclose with an amount of β-CD, drying promptly gets clathrate, and is standby; With the medicinal residues ethanol extraction secondary behind the above-mentioned supercritical extraction, merge secondary filtrate, reclaim ethanol and concentrate standby; Get Fructus Jujubae and decoct with water secondary, filter; Merging filtrate concentrates, and with above-mentioned alcohol extract condensed cream mixing, drying is ground into fine powder, with clathrate, Semen Crotonis Pulveratum, the Moschus mixing that sieves, sieves again, and is standby; Make tablet according to method for preparing tablet thereof.
Embodiment 2
A. take off column weight amount proportioning crude drug: Flos Caryophylli 100g, Lignum Aquilariae Resinatum 600g, Fructus Aurantii 600g, Lignum Santali Albi 360g, Radix Et Rhizoma Rhei 360g, Cortex Magnoliae Officinalis 600g, Moschus 18g, Semen Crotonis Pulveratum 240g, Fructus Jujubae 2000g, Rhizoma Chuanxiong 360g are standby;
B. go up ten flavor medicines, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is standby; Six-element medicated powder such as Flos Caryophylli, Lignum Aquilariae Resinatum, Lignum Santali Albi, Fructus Aurantii, Cortex Magnoliae Officinalis, Rhizoma Chuanxiong are broken into coarse powder, add water, soak, and decocting boils distillation, collect volatile oil, and are with after β-CD inclusion, standby; Decocting liquid filters, and filtrate concentrates standby, and medicinal residues and Radix Et Rhizoma Rhei coarse powder add alcohol reflux 2 times, filters; Merge secondary filtrate, concentrate, drying, standby; Get Fructus Jujubae, add decocting and boil secondary, filter; Merge secondary filtrate, concentrate, drying, the above-mentioned fine powder that is dried and crushed into, with Semen Crotonis Pulveratum, Moschus mixing, standby; Make granule according to process for producing granula, promptly.
Embodiment 3
A. take off column weight amount proportioning crude drug: Flos Caryophylli 200g, Lignum Aquilariae Resinatum 150g, Fructus Aurantii 600g, Lignum Santali Albi 360g, Radix Et Rhizoma Rhei 90g, Cortex Magnoliae Officinalis 200g, Moschus 10g, Semen Crotonis Pulveratum 80g, Fructus Jujubae 1500g, Rhizoma Chuanxiong 300g are standby;
B. above ten flavors, Semen Crotonis Pulveratum, Moschus pulverize separately become fine powder; Eight flavor medicines such as all the other Flos Caryophyllis, Lignum Aquilariae Resinatum decoct with water 2 times, and each 2 hours, collecting decoction filtered, and is condensed into thick paste, adds Semen Crotonis Pulveratum, Moschus powder in above-mentioned thick paste, and mixing is standby; Get an amount of polyethylene glycol 6000, heating makes fusion, adds above-mentioned thick paste and Semen Crotonis Pulveratum, Moschus mixture of powders, mixing, and adopting a speed is 85～90/min, splashes in the refrigerative liquid paraffin, makes drop pill, promptly.
Embodiment 4
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 250g, Flos Caryophylli 150g, Fructus Aurantii 200g, Lignum Santali Albi 150g, Radix Et Rhizoma Rhei 250g, Cortex Magnoliae Officinalis 250g, Moschus 6g, Semen Crotonis Pulveratum 100g, Fructus Jujubae 800g, Rhizoma Chuanxiong 150g are standby;
B. above ten flavors, Semen Crotonis Pulveratum, Moschus pulverize separately become fine powder; Eight flavor medicines such as all the other Radix Aucklandiae, Flos Caryophylli decoct with water 2 times, and each 3 hours, collecting decoction filtered, and is condensed into thick paste, adds above-mentioned thick paste and Semen Crotonis Pulveratum, Moschus powder, and mixing is standby; Get an amount of Macrogol 4000, heating makes fusion, adds said mixture, mixing, and adopting a speed is 60～80/min, splashes in the refrigerative methyl-silicone oil, makes drop pill, promptly.
Embodiment 5
A. take off column weight amount proportioning crude drug: Flos Caryophylli 100g, Radix Aucklandiae 400g, Fructus Aurantii 400g, Lignum Santali Albi 250g, Radix Et Rhizoma Rhei 250g, Cortex Magnoliae Officinalis 400g, Moschus 12g, Semen Crotonis Pulveratum 150g, Fructus Jujubae 1200g, Rhizoma Chuanxiong 250g are standby;
B. above ten flavors, Semen Crotonis Pulveratum, Moschus pulverize separately become fine powder; Eight flavor medicines such as all the other Radix Aucklandiae, Flos Caryophylli decoct with water 3 times, and each 2 hours, collecting decoction filtered, and is condensed into thick paste, adds above-mentioned thick paste and Semen Crotonis Pulveratum, Moschus powder, and mixing is standby; Get an amount of polyethylene glycol 6000: polyethylene glycol 1500 is 3: 1 a mixture, and heating dissolves, and adds above-mentioned thick paste and Semen Crotonis Pulveratum, Moschus powder, mixing, and adopting a speed is 20～80/min, splashes in the refrigerative liquid paraffin, makes drop pill, promptly.
Embodiment 6
A. take off column weight amount proportioning crude drug: Flos Caryophylli 80g, Lignum Aquilariae Resinatum 300g, Fructus Aurantii (parched with bran) 200g, Lignum Santali Albi 180g, Radix Et Rhizoma Rhei 180g, Cortex Magnoliae Officinalis (Rhizoma Zingiberis Recens is processed) 300g, Moschus 9g, Semen Crotonis Pulveratum 120g, Fructus Jujubae (enucleation) 1000g, Rhizoma Chuanxiong 180g are standby;
B. above ten flavors, Semen Crotonis Pulveratum, Moschus pulverize separately become fine powder; Eight flavor medicines such as all the other Flos Caryophyllis, Lignum Aquilariae Resinatum decoct with water 2 times, and each 2 hours, collecting decoction filters, and is condensed into thick paste, and was standby; Taking polyethylene glycol 6000: the mixture Polyethylene Glycol of Macrogol 4000=4: 3 is an amount of, and heating makes fusion, adds above-mentioned thick paste and Semen Crotonis Pulveratum, Moschus powder, mixing, adopting a speed is 40～60/min, splashes in the refrigerative liquid paraffin, make drop pill, promptly.
Embodiment 7
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 250g, Flos Caryophylli 200g, Fructus Aurantii (parched with bran) 250g, Lignum Santali Albi 180g, Radix Et Rhizoma Rhei 180g, Cortex Magnoliae Officinalis (Rhizoma Zingiberis Recens is processed) 300g, Moschus 9g, Semen Crotonis Pulveratum 120g, Fructus Jujubae (enucleation) 1200g, Rhizoma Chuanxiong 180g are standby;
B. above ten flavors, Semen Crotonis Pulveratum, Moschus pulverize separately become fine powder; All the other eight flavors are ground into fine powder, and with Semen Crotonis Pulveratum, Moschus powder facing-up, mixing sieves, and is standby; Use water pill, cold drying, promptly.
Embodiment 8
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 400g, Flos Caryophylli 60g, Fructus Aurantii 300g, Lignum Santali Albi 150g, Radix Et Rhizoma Rhei 250g, Cortex Magnoliae Officinalis 250g, Moschus 10g, Semen Crotonis Pulveratum 100g, Fructus Jujubae 1200g, Rhizoma Chuanxiong 150g are standby;
B. above ten flavors, Semen Crotonis Pulveratum, Moschus pulverize separately become fine powder; Eight flavor medicines such as all the other Radix Aucklandiae, Flos Caryophylli decoct with water 2 times, and each 2 hours, collecting decoction filters, and is condensed into thick paste, and was standby; Taking polyethylene glycol 6000: the mixture Polyethylene Glycol of Macrogol 4000=3: 2 is an amount of, and heating makes fusion, adds above-mentioned thick paste and Semen Crotonis Pulveratum, Moschus powder, mixing, adopt dripping speed is 50～60/min, splashes into methyl-silicone oil: in the condensed fluid of liquid Paraffin=4: 1, promptly get drop pill, promptly.
Embodiment 9
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 280g, Flos Caryophylli 120g, Fructus Aurantii 360g, Lignum Santali Albi 180g, Radix Et Rhizoma Rhei 200g, Cortex Magnoliae Officinalis 400g, Moschus 8g, Semen Crotonis Pulveratum 120g, Fructus Jujubae 900g, Rhizoma Chuanxiong 180g are standby;
B. above ten flavor medicines, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is standby; Six-element medicated powder such as Flos Caryophylli, the Radix Aucklandiae, Lignum Santali Albi, Fructus Aurantii, Cortex Magnoliae Officinalis, Rhizoma Chuanxiong are broken into coarse powder, add 16 times of water gagings, soak 4 hours, and decocting boils distillation 8h altogether, collects volatile oil, and is with after β-CD inclusion, standby; Decocting liquid filters, and relative density 1.25-1.30 was standby when filtrate was concentrated into 60 ℃, and medicinal residues and Radix Et Rhizoma Rhei coarse powder add 70% alcohol reflux 2 times, for the first time 2h; 1h filters for the second time; Merge secondary filtrate, relative density 1.20-1.25 when being concentrated into 60 ℃, drying, standby; Get Fructus Jujubae, add decocting and boil secondary, each 2h filters; Merge secondary filtrate, and relative density 1.28-1.32 when being concentrated into 60 ℃ (60 ℃, drying, standby with the above-mentioned fine powder that is dried and crushed into Semen Crotonis Pulveratum, Moschus mixing, make granule.
Embodiment 10
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 300g, Flos Caryophylli 50g, Fructus Aurantii (parched with bran) 350g, Lignum Santali Albi 200g, Radix Et Rhizoma Rhei 200g, Cortex Magnoliae Officinalis (Rhizoma Zingiberis Recens is processed) 300g, Moschus 7g, Semen Crotonis Pulveratum 120g, Fructus Jujubae (enucleation) 1000g, Rhizoma Chuanxiong 200g are standby;
B. above ten flavor medicines, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is standby; Flos Caryophylli, the Radix Aucklandiae, Lignum Santali Albi, Fructus Aurantii, Cortex Magnoliae Officinalis, Rhizoma Chuanxiong, Radix Et Rhizoma Rhei powder are broken into 40 purpose powder, CO 2Supercritical extraction, extracting pressure 5MPa, 35 ℃ of temperature, CO 2Flow velocity 20L/h, extraction 2h; Get extract, add an amount of anhydrous alcohol solution,, adopt polishing to carry out enclose,, promptly get clathrate in 40 ℃ of vacuum dryings with an amount of β-CD, standby; Medicinal residues behind the above-mentioned supercritical extraction are added 60% ethanol extraction secondary, merge secondary filtrate, reclaiming ethanol to relative density is that 1.25-1.30 (60 ℃) is standby; Get Fructus Jujubae and decoct with water secondary, each 2h filters; Merging filtrate is concentrated into relative density 1.25-1.30 (60 ℃), and with above-mentioned alcohol extract condensed cream mixing, drying is ground into fine powder, with clathrate, Semen Crotonis Pulveratum, the Moschus mixing that sieves, crosses 80 mesh sieves again, and is standby, makes tablet according to method for preparing tablet thereof.
Embodiment 11
A. take off column weight amount proportioning crude drug: Flos Caryophylli 150g, Lignum Aquilariae Resinatum 150g, Fructus Aurantii 150g, Lignum Santali Albi 90g, Radix Et Rhizoma Rhei 90g, Cortex Magnoliae Officinalis 150g, Moschus 4.5g, Semen Crotonis Pulveratum 60g, Fructus Jujubae 500g, Rhizoma Chuanxiong 90g are standby;
B. above ten flavor medicines, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is standby; Flos Caryophylli, Lignum Aquilariae Resinatum, Lignum Santali Albi, Fructus Aurantii, Cortex Magnoliae Officinalis, Rhizoma Chuanxiong, Radix Et Rhizoma Rhei are pulverized CO 2Supercritical extraction; Get extract, add an amount of anhydrous alcohol solution, carry out enclose with an amount of β-CD, drying promptly gets clathrate, and is standby; With the medicinal residues ethanol extraction secondary behind the above-mentioned supercritical extraction, merge secondary filtrate, reclaim ethanol and concentrate standby; Get Fructus Jujubae and decoct with water secondary, filter; Merging filtrate concentrates, and with above-mentioned alcohol extract condensed cream mixing, drying is ground into fine powder, with clathrate, Semen Crotonis Pulveratum, the Moschus mixing that sieves, sieves again, and is standby, encapsulated, promptly.
Embodiment 12
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 600g, Flos Caryophylli 120g, Fructus Aurantii 600g, Lignum Santali Albi 360g, Radix Et Rhizoma Rhei 360g, Cortex Magnoliae Officinalis 600g, Moschus 18g, Semen Crotonis Pulveratum 240g, Fructus Jujubae 2000g, Rhizoma Chuanxiong 360g are standby;
B. above ten flavor medicines, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is standby; Six-element medicated powder such as Flos Caryophylli, the Radix Aucklandiae, Lignum Santali Albi, Fructus Aurantii, Cortex Magnoliae Officinalis, Rhizoma Chuanxiong are broken into coarse powder, add water, soak, and decocting boils distillation, collect volatile oil, and are with after β-CD inclusion, standby; Decocting liquid filters, and filtrate concentrates standby, and medicinal residues and Radix Et Rhizoma Rhei coarse powder add alcohol reflux 2 times, filters; Merge secondary filtrate, concentrate, drying, standby; Get Fructus Jujubae, add decocting and boil secondary, filter; Merge secondary filtrate, concentrate, drying, the above-mentioned fine powder that is dried and crushed into, standby, encapsulated with Semen Crotonis Pulveratum, Moschus mixing, promptly.
Embodiment 13
A. take off column weight amount proportioning crude drug: Flos Caryophylli 200g, Lignum Aquilariae Resinatum 150g, Fructus Aurantii 600g, Lignum Santali Albi 360g, Radix Et Rhizoma Rhei 90g, Cortex Magnoliae Officinalis 200g, Moschus 10g, Semen Crotonis Pulveratum 80g, Fructus Jujubae 1500g, Rhizoma Chuanxiong 300g are standby;
B. above ten flavors, Semen Crotonis Pulveratum, Moschus pulverize separately become fine powder; All the other eight flavors are ground into fine powder, and with Semen Crotonis Pulveratum, Moschus powder facing-up, mixing sieves, and is standby; Use water pill, cold drying, promptly.
Embodiment 14
A. take off column weight amount proportioning crude drug: Flos Caryophylli 250g, Lignum Aquilariae Resinatum 250g, Fructus Aurantii 250g, Lignum Santali Albi 150g, Radix Et Rhizoma Rhei 250g, Cortex Magnoliae Officinalis 250g, Moschus 6g, Semen Crotonis Pulveratum 100g, Fructus Jujubae 800g, Rhizoma Chuanxiong 150g are standby;
B. go up ten flavors, Semen Crotonis Pulveratum, Moschus pulverize separately become fine powder; All the other eight flavor medicines decoct with water 2 times, and each 3 hours, collecting decoction filtered, and is condensed into thick paste; In above-mentioned thick paste, add Semen Crotonis Pulveratum, Moschus powder, mixing, standby; Encapsulated, promptly.
Embodiment 15
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 400g, Flos Caryophylli 150g, Fructus Aurantii 400g, Lignum Santali Albi 250g, Radix Et Rhizoma Rhei 250g, Cortex Magnoliae Officinalis 400g, artificial Moschus 12g, Semen Crotonis Pulveratum 150g, Fructus Jujubae 1200g, Rhizoma Chuanxiong 250g are standby;
B. above ten flavor medicines, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is standby; Flos Caryophylli, the Radix Aucklandiae, Lignum Santali Albi, Fructus Aurantii, Cortex Magnoliae Officinalis, Rhizoma Chuanxiong, Radix Et Rhizoma Rhei powder are broken into 80 purpose powder, CO 2Supercritical extraction, extracting pressure 40MPa, 60 ℃ of temperature, CO 2Flow velocity 35L/h, extraction 5h; Get extract, add an amount of anhydrous alcohol solution,, adopt polishing to carry out enclose,, promptly get clathrate in 40 ℃ of vacuum dryings with an amount of β-CD, standby; Medicinal residues behind the above-mentioned supercritical extraction are added 60% ethanol extraction secondary, merge secondary filtrate, relative density is that 1.25-1.30 is standby when reclaiming ethanol to 60 ℃; Get Fructus Jujubae and decoct with water secondary, each 2h filters; Merging filtrate, relative density 1.25-1.30 when being concentrated into 60 ℃, with above-mentioned alcohol extract condensed cream mixing, drying is ground into fine powder, with clathrate, Semen Crotonis Pulveratum, the Moschus mixing that sieves, crosses 80 mesh sieves again, and is standby; Encapsulated, promptly.
Embodiment 16
A. take off column weight amount proportioning crude drug: Flos Caryophylli 300g, Lignum Aquilariae Resinatum 300g, Fructus Aurantii (parched with bran) 300g, Lignum Santali Albi 180g, Radix Et Rhizoma Rhei 180g, Cortex Magnoliae Officinalis (Rhizoma Zingiberis Recens is processed) 300g, Moschus 9g, Semen Crotonis Pulveratum 120g, Fructus Jujubae (enucleation) 1000g, Rhizoma Chuanxiong 180g are standby;
B. above ten flavor medicines, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is standby; Six-element medicated powder such as Flos Caryophylli, Lignum Aquilariae Resinatum, Lignum Santali Albi, Fructus Aurantii, Cortex Magnoliae Officinalis, Rhizoma Chuanxiong are broken into coarse powder, add 16 times of water gagings, soak 4 hours, and decocting boils distillation 8h altogether, collects volatile oil, and is with after β-CD inclusion, standby; Decocting liquid filters, and relative density 1.25-1.30 was standby when filtrate was concentrated into 60 ℃, and medicinal residues and Radix Et Rhizoma Rhei coarse powder add 70% alcohol reflux 2 times, for the first time 2h; 1h filters for the second time; Merge secondary filtrate, relative density 1.20-1.25 when being concentrated into 60 ℃, drying, standby; Get Fructus Jujubae, add decocting and boil secondary, each 2h filters; Merge secondary filtrate, relative density 1.28-1.32 when being concentrated into 60 ℃, drying, standby with the above-mentioned fine powder that is dried and crushed into Semen Crotonis Pulveratum, Moschus mixing, add appropriate amount of auxiliary materials, make 36000 capsules, promptly.
Embodiment 17
A. take off column weight amount proportioning crude drug: Flos Caryophylli 50g, Lignum Aquilariae Resinatum 300g, Fructus Aurantii (parched with bran) 250g, Lignum Santali Albi 180g, Radix Et Rhizoma Rhei 180g, Cortex Magnoliae Officinalis (Rhizoma Zingiberis Recens is processed) 300g, artificial Moschus 9g, Semen Crotonis Pulveratum 120g, Fructus Jujubae (enucleation) 1200g, Rhizoma Chuanxiong 180g are standby;
B. above ten flavors, Semen Crotonis Pulveratum, Moschus pulverize separately become fine powder; All the other eight flavor medicines decoct with water 2 times, and each 2 hours, collecting decoction filtered, and is condensed into thick paste; In above-mentioned thick paste, add Semen Crotonis Pulveratum, Moschus powder, mixing, standby; Add sodium carboxymethyl cellulose, Icing Sugar, mixing, the system granule sieves, drying, promptly.
Embodiment 18
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 400g, Flos Caryophylli 120g, Fructus Aurantii 400g, Lignum Santali Albi 150g, Radix Et Rhizoma Rhei 250g, Cortex Magnoliae Officinalis 250g, Moschus 10g, Semen Crotonis Pulveratum 100g, Fructus Jujubae 1200g, Rhizoma Chuanxiong 150g are standby;
B. above ten flavors, Semen Crotonis Pulveratum, Moschus pulverize separately become fine powder; All the other eight flavors are ground into fine powder, and with Semen Crotonis Pulveratum, Moschus powder facing-up, mixing sieves, and is standby; Use water pill, cold drying, promptly.
Embodiment 19
A. take off column weight amount proportioning crude drug: Flos Caryophylli 150g, Lignum Aquilariae Resinatum 150g, Fructus Aurantii 150g, Lignum Santali Albi 90g, Radix Et Rhizoma Rhei 90g, Cortex Magnoliae Officinalis 150g, Moschus 4.5g, Semen Crotonis Pulveratum 60g, Fructus Jujubae 500g, Rhizoma Chuanxiong 90g are standby;
B. above ten flavor medicines, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is standby; Flos Caryophylli, the Radix Aucklandiae, Lignum Santali Albi, Fructus Aurantii, Cortex Magnoliae Officinalis, Rhizoma Chuanxiong, Radix Et Rhizoma Rhei are pulverized CO 2Supercritical extraction; Get extract, add an amount of anhydrous alcohol solution, carry out enclose with an amount of β-CD, drying promptly gets clathrate, and is standby; With the medicinal residues ethanol extraction secondary behind the above-mentioned supercritical extraction, merge secondary filtrate, reclaim ethanol and concentrate standby; Get Fructus Jujubae and decoct with water secondary, filter; Merging filtrate concentrates, and with above-mentioned alcohol extract condensed cream mixing, drying is ground into fine powder, with clathrate, Semen Crotonis Pulveratum, the Moschus mixing that sieves, sieves again, and is standby; Add an amount of magnesium stearate, mixing, compacting, promptly.
Embodiment 20
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 600g, Flos Caryophylli 180g, Fructus Aurantii 200g, Lignum Santali Albi 360g, Radix Et Rhizoma Rhei 360g, Cortex Magnoliae Officinalis 600g, Moschus 18g, Semen Crotonis Pulveratum 240g, Fructus Jujubae 2000g, Rhizoma Chuanxiong 360g are standby;
B. above ten flavor medicines, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is standby; Six-element medicated powder such as Flos Caryophylli, the Radix Aucklandiae, Lignum Santali Albi, Fructus Aurantii, Cortex Magnoliae Officinalis, Rhizoma Chuanxiong are broken into coarse powder, add water, soak, and decocting boils distillation, collect volatile oil, and are with after β-CD inclusion, standby; Decocting liquid filters, and filtrate concentrates standby, and medicinal residues and Radix Et Rhizoma Rhei coarse powder add alcohol reflux 2 times, filters; Merge secondary filtrate, concentrate, drying, standby; Get Fructus Jujubae, add decocting and boil secondary, filter; Merge secondary filtrate, concentrate, drying, the above-mentioned fine powder that is dried and crushed into, with Semen Crotonis Pulveratum, Moschus mixing, standby; Add an amount of magnesium stearate, mixing, compacting, promptly.
Embodiment 21
A. take off column weight amount proportioning crude drug: Flos Caryophylli 200g, Lignum Aquilariae Resinatum 150g, Fructus Aurantii 600g, Lignum Santali Albi 360g, Radix Et Rhizoma Rhei 90g, Cortex Magnoliae Officinalis 200g, artificial Moschus 10g, Semen Crotonis Pulveratum 80g, Fructus Jujubae 1500g, Rhizoma Chuanxiong 300g are standby;
B. above ten flavors, Semen Crotonis Pulveratum, Moschus pulverize separately become fine powder; All the other eight flavor medicines decoct with water 3 times, and each 3 hours, collecting decoction filtered, and is condensed into thick paste; In above-mentioned thick paste, add Semen Crotonis Pulveratum, Moschus powder, mixing, standby; Add mixings such as starch, microcrystalline Cellulose, sieve, make granule, add volatile oil such as the Radix Aucklandiae again, mixing, drying adds an amount of magnesium stearate, mixing, compacting, promptly.
Embodiment 22
A. take off column weight amount proportioning crude drug: Flos Caryophylli 90g, Lignum Aquilariae Resinatum 250g, Fructus Aurantii 250g, Lignum Santali Albi 150g, Radix Et Rhizoma Rhei 250g, Cortex Magnoliae Officinalis 250g, Moschus 6g, Semen Crotonis Pulveratum 100g, Fructus Jujubae 800g, Rhizoma Chuanxiong 150g are standby;
B. above ten flavor medicines, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is standby; Flos Caryophylli, Lignum Aquilariae Resinatum, Lignum Santali Albi, Fructus Aurantii, Cortex Magnoliae Officinalis, Rhizoma Chuanxiong, Radix Et Rhizoma Rhei powder are broken into 60 purpose powder, CO 2Supercritical extraction, extracting pressure 10MPa, 50 ℃ of temperature, CO 2Flow velocity 25L/h, extraction 3h; Get extract, add an amount of anhydrous alcohol solution,, adopt polishing to carry out enclose,, promptly get clathrate in 40 ℃ of vacuum dryings with an amount of β-CD, standby; Medicinal residues behind the above-mentioned supercritical extraction are added 60% ethanol extraction secondary, merge secondary filtrate, relative density is that 1.25-1.30 is standby when reclaiming ethanol to 60 ℃; Get Fructus Jujubae and decoct with water secondary, each 2h filters; Merging filtrate, relative density 1.25-1.30 when being concentrated into 60 ℃, with above-mentioned alcohol extract condensed cream mixing, drying is ground into fine powder, with clathrate, Semen Crotonis Pulveratum, the Moschus mixing that sieves, crosses 80 mesh sieves again, and is standby; Add 2 ‰ magnesium stearate, mixing, compacting is in blocks, promptly.
Embodiment 23
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 400g, Flos Caryophylli 70g, Fructus Aurantii 400g, Lignum Santali Albi 250g, Radix Et Rhizoma Rhei 250g, Cortex Magnoliae Officinalis 400g, Moschus 12g, Semen Crotonis Pulveratum 150g, Fructus Jujubae 1200g, Rhizoma Chuanxiong 250g are standby;
B. above ten flavor medicines, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is standby; Six-element medicated powder such as Flos Caryophylli, the Radix Aucklandiae, Lignum Santali Albi, Fructus Aurantii, Cortex Magnoliae Officinalis, Rhizoma Chuanxiong are broken into coarse powder, add 10 times of water gagings, soak 4 hours, and decocting boils distillation 8h altogether, collects volatile oil, and is with after β-CD inclusion, standby; Decocting liquid filters, and relative density 1.25-1.30 was standby when filtrate was concentrated into 60 ℃, and medicinal residues and Radix Et Rhizoma Rhei coarse powder add 70% alcohol reflux 2 times, for the first time 2h; 1h filters for the second time; Merge secondary filtrate, relative density 1.20-1.25 when being concentrated into 60 ℃, drying, standby; Get Fructus Jujubae, add decocting and boil secondary, each 2h filters; Merge secondary filtrate, relative density 1.28-1.32 when being concentrated into 60 ℃, drying, with the above-mentioned fine powder that is dried and crushed into,, standby with Semen Crotonis Pulveratum, Moschus mixing; Add 12 ‰ magnesium stearate, mixing, compacting is in blocks, promptly.
Embodiment 24
A. take off column weight amount proportioning crude drug: Flos Caryophylli 150g, Lignum Aquilariae Resinatum 300g, Fructus Aurantii (parched with bran) 300g, Lignum Santali Albi 180g, Radix Et Rhizoma Rhei 180g, Cortex Magnoliae Officinalis (Rhizoma Zingiberis Recens is processed) 300g, Moschus 9g, Semen Crotonis Pulveratum 120g, Fructus Jujubae (enucleation) 1000g, Rhizoma Chuanxiong 180g are standby;
B. above ten flavors, Semen Crotonis Pulveratum, Moschus pulverize separately become fine powder; All the other eight flavors are ground into fine powder, and with Semen Crotonis Pulveratum, Moschus powder facing-up, mixing sieves, and is standby; Use water pill, cold drying, promptly.
Embodiment 25
A. take off column weight amount proportioning crude drug: Flos Caryophylli 150g, Lignum Aquilariae Resinatum 150g, Fructus Aurantii 150g, Lignum Santali Albi 90g, Radix Et Rhizoma Rhei 90g, Cortex Magnoliae Officinalis 150g, Moschus 4.5g, Semen Crotonis Pulveratum 60g, Fructus Jujubae 500g, Rhizoma Chuanxiong 90g are standby;
B. above ten flavors, Semen Crotonis Pulveratum, Moschus pulverize separately become fine powder; All the other eight flavor medicines decoct with water 2 times, and each 2 hours, collecting decoction filtered, and is condensed into thick paste; In above-mentioned thick paste, add Semen Crotonis Pulveratum, Moschus powder, mixing, standby; It is an amount of to add vegetable oil, and mixing is made soft capsule, promptly.
Embodiment 26
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 600g, Flos Caryophylli 180g, Fructus Aurantii 600g, Lignum Santali Albi 360g, Radix Et Rhizoma Rhei 360g, Cortex Magnoliae Officinalis 600g, artificial Moschus 18g, Semen Crotonis Pulveratum 240g, Fructus Jujubae 2000g, Rhizoma Chuanxiong 360g are standby;
B. above ten flavor medicines, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is standby; Six-element medicated powder such as Flos Caryophylli, the Radix Aucklandiae, Lignum Santali Albi, Fructus Aurantii, Cortex Magnoliae Officinalis, Rhizoma Chuanxiong are broken into coarse powder, add 12 times of water gagings, soak 4 hours, and decocting boils distillation 8h altogether, collects volatile oil, and is with after β-CD inclusion, standby; Decocting liquid filters, and relative density 1.25-1.30 was standby when filtrate was concentrated into 60 ℃, and medicinal residues and Radix Et Rhizoma Rhei coarse powder add 70% alcohol reflux 2 times, for the first time 2h; 1h filters for the second time; Merge secondary filtrate, relative density 1.20-1.25 when being concentrated into 60 ℃, drying, standby; Get Fructus Jujubae, add decocting and boil secondary, each 2h filters; Merge secondary filtrate, relative density 1.28-1.32 when being concentrated into 60 ℃, drying, with the above-mentioned fine powder that is dried and crushed into,, standby with Semen Crotonis Pulveratum, Moschus mixing; It is an amount of to add vegetable oil, and mixing is made soft capsule, promptly.
Embodiment 27
A. take off column weight amount proportioning crude drug: Flos Caryophylli 100g, Lignum Aquilariae Resinatum 300g, Fructus Aurantii (parched with bran) 300g, Lignum Santali Albi 180g, Radix Et Rhizoma Rhei 180g, Cortex Magnoliae Officinalis (Rhizoma Zingiberis Recens is processed) 300g, Moschus 9g, Semen Crotonis Pulveratum 120g, Fructus Jujubae (enucleation) 1000g, Rhizoma Chuanxiong 180g are standby;
B. above ten flavor medicines, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is standby; Flos Caryophylli, Lignum Aquilariae Resinatum, Lignum Santali Albi, Fructus Aurantii, Cortex Magnoliae Officinalis, Rhizoma Chuanxiong, Radix Et Rhizoma Rhei powder are broken into 50 purpose powder, CO 2Supercritical extraction, extracting pressure 15MPa, temperature 35-60 ℃, CO 2Flow velocity 25L/h, extraction 3h; Get extract, add an amount of anhydrous alcohol solution,, adopt polishing to carry out enclose,, promptly get clathrate in 40 ℃ of vacuum dryings with an amount of β-CD, standby; Medicinal residues behind the above-mentioned supercritical extraction are added 60% ethanol extraction secondary, merge secondary filtrate, relative density is that 1.25-1.30 is standby when reclaiming ethanol to 60 ℃; Get Fructus Jujubae and decoct with water secondary, each 2h filters; Merging filtrate, relative density 1.25-1.30 when being concentrated into 60 ℃, with above-mentioned alcohol extract condensed cream mixing, drying is ground into fine powder, with clathrate, Semen Crotonis Pulveratum, the Moschus mixing that sieves, crosses 80 mesh sieves again, and is standby; It is an amount of to add vegetable oil, makes 36000 soft capsules, promptly.
Embodiment 28
A. take off column weight amount proportioning crude drug: Flos Caryophylli 300g, Lignum Aquilariae Resinatum 350g, Fructus Aurantii (parched with bran) 350g, Lignum Santali Albi 200g, Radix Et Rhizoma Rhei 200g, Cortex Magnoliae Officinalis (Rhizoma Zingiberis Recens is processed) 300g, Moschus 7g, Semen Crotonis Pulveratum 120g, Fructus Jujubae (enucleation) 1000g, Rhizoma Chuanxiong 200g are standby;
B. above ten flavors, Semen Crotonis Pulveratum, Moschus pulverize separately become fine powder; All the other eight flavor medicines decoct with water 2 times, and each 2 hours, collecting decoction filtered, and is condensed into thick paste; In above-mentioned thick paste, add Semen Crotonis Pulveratum, Moschus powder, mixing, standby; It is an amount of to add vegetable oil, and mixing is made soft capsule, promptly.
Embodiment 29
A. take off column weight amount proportioning crude drug: Flos Caryophylli 150g, Lignum Aquilariae Resinatum 150g, Fructus Aurantii 150g, Lignum Santali Albi 90g, Radix Et Rhizoma Rhei 90g, Cortex Magnoliae Officinalis 150g, Moschus 4.5g, Semen Crotonis Pulveratum 60g, Fructus Jujubae 500g, Rhizoma Chuanxiong 90g are standby;
B. Semen Crotonis Pulveratum, Moschus pulverize separately become fine powder; Flos Caryophylli, Lignum Aquilariae Resinatum, Fructus Aurantii, Lignum Santali Albi, Radix Et Rhizoma Rhei, Cortex Magnoliae Officinalis, Fructus Jujubae, Rhizoma Chuanxiong eight flavors are ground into fine powder; With Semen Crotonis Pulveratum, Moschus powder facing-up, mixing sieves; Get above-mentioned hybrid medicine powder 569g, add glycerol 6000g, Al (OH) 380g, sodium acrylate 1500g mix homogeneously are component A; Get tartaric acid 40g, add distilled water 13500g, acrylate copolymer 800g, dissolving is B component; B component slowly adds among the component A, stirs, and coating, compound with protecting film, cut promptly.
Embodiment 30
A. take off column weight amount proportioning crude drug: Flos Caryophylli 100g, Lignum Aquilariae Resinatum 600g, Fructus Aurantii 600g, Lignum Santali Albi 360g, Radix Et Rhizoma Rhei 360g, Cortex Magnoliae Officinalis 600g, artificial Moschus 18g, Semen Crotonis Pulveratum 240g, Fructus Jujubae 2000g, Rhizoma Chuanxiong 360g are standby;
B. above ten flavor medicines, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is standby; Flos Caryophylli, the Radix Aucklandiae, Lignum Santali Albi, Fructus Aurantii, Cortex Magnoliae Officinalis, Rhizoma Chuanxiong, Radix Et Rhizoma Rhei powder are broken into 740-80 purpose powder, CO 2Supercritical extraction, extracting pressure 15MPa, 40 ℃ of temperature, CO 2Flow velocity 30L/h, extraction 2.5h; Get extract, add an amount of anhydrous alcohol solution,, adopt polishing to carry out enclose,, promptly get clathrate in 40 ℃ of vacuum dryings with an amount of β-CD, standby; Medicinal residues behind the above-mentioned supercritical extraction are added 60% ethanol extraction secondary, merge secondary filtrate, relative density is that 1.25-1.30 is standby when reclaiming ethanol to 60 ℃; Get Fructus Jujubae and decoct with water secondary, each 2h filters; Merging filtrate, relative density 1.25-1.30 when being concentrated into 60 ℃, with above-mentioned alcohol extract condensed cream mixing, drying is ground into fine powder, with clathrate, Semen Crotonis Pulveratum, the Moschus mixing that sieves, crosses 80 mesh sieves again, and is standby; Get above-mentioned hybrid medicine powder 4000g, add glycerol 23550g, Al (OH) 3156g, sodium acrylate 2758g mix homogeneously are component A; Get tartaric acid 72g, add distilled water 17340g, acrylate copolymer 1236g, dissolving is B component; B component slowly adds among the component A, stirs, and coating, compound with protecting film, cut promptly.
Embodiment 31
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 200g, Flos Caryophylli 150g, Fructus Aurantii 600g, Lignum Santali Albi 360g, Radix Et Rhizoma Rhei 90g, Cortex Magnoliae Officinalis 200g, Moschus 10g, Semen Crotonis Pulveratum 80g, Fructus Jujubae 1500g, Rhizoma Chuanxiong 300g are standby;
B. above ten flavor medicines, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is standby; Six-element medicated powder such as Flos Caryophylli, the Radix Aucklandiae, Lignum Santali Albi, Fructus Aurantii, Cortex Magnoliae Officinalis, Rhizoma Chuanxiong are broken into coarse powder, add 16 times of water gagings, soak 4 hours, and decocting boils distillation 8h altogether, collects volatile oil, and is with after β-CD inclusion, standby; Decocting liquid filters, and relative density 1.25-1.30 was standby when filtrate was concentrated into 60 ℃, and medicinal residues and Radix Et Rhizoma Rhei coarse powder add 70% alcohol reflux 2 times, for the first time 2h; 1h filters for the second time; Merge secondary filtrate, relative density 1.20-1.25 when being concentrated into 60 ℃, drying, standby; Get Fructus Jujubae, add decocting and boil secondary, each 2h filters; Merge secondary filtrate, relative density 1.28-1.32 when being concentrated into 60 ℃, drying, with the above-mentioned fine powder that is dried and crushed into,, standby with Semen Crotonis Pulveratum, Moschus mixing; Get above-mentioned hybrid medicine powder 2200g, add glycerol 12000g, Al (OH) 3150g, sodium acrylate 2800g mix homogeneously are component A; Get tartaric acid 95g, add distilled water 26000g, acrylate copolymer 2500g, dissolving is B component; B component slowly adds among the component A, stirs, and coating, compound with protecting film, cut promptly.
Embodiment 32
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 250g, Flos Caryophylli 150g, Fructus Aurantii 250g, Lignum Santali Albi 150g, Radix Et Rhizoma Rhei 250g, Cortex Magnoliae Officinalis 250g, artificial Moschus 6g, Semen Crotonis Pulveratum 100g, Fructus Jujubae 800g, Rhizoma Chuanxiong 150g are standby;
B. above ten flavors, Semen Crotonis Pulveratum, Moschus pulverize separately become fine powder; All the other eight flavor medicines decoct with water 2 times, and each 2 hours, collecting decoction filtered, and is condensed into thick paste; In above-mentioned thick paste, add Semen Crotonis Pulveratum, Moschus powder, mixing, standby; Get above-mentioned hybrid medicine powder 1800g, add glycerol 8000g, Al (OH) 345g, sodium acrylate 2000g mix homogeneously are component A; Get tartaric acid 90g, add distilled water 27000g, acrylate copolymer 1800g, dissolving is B component; B component slowly adds among the component A, stirs, and coating, compound with protecting film, cut promptly.
Embodiment 33
A. take off column weight amount proportioning crude drug: Flos Caryophylli 100g, Lignum Aquilariae Resinatum 300g, Fructus Aurantii (parched with bran) 300g, Lignum Santali Albi 180g, Radix Et Rhizoma Rhei 180g, Cortex Magnoliae Officinalis (Rhizoma Zingiberis Recens is processed) 300g, Moschus 9g, Semen Crotonis Pulveratum 120g, Fructus Jujubae (enucleation) 1000g, Rhizoma Chuanxiong 180g are standby;
B. above ten flavors, Semen Crotonis Pulveratum, Moschus pulverize separately become fine powder; All the other eight flavor medicines decoct with water 2 times, and each 2 hours, collecting decoction filtered, and is condensed into thick paste; In above-mentioned thick paste, add Semen Crotonis Pulveratum, Moschus powder, mixing, standby; Get above-mentioned hybrid medicine powder 2869g, add glycerol 13770g, Al (OH) 3183g, sodium acrylate 2754g mix homogeneously are component A; Get tartaric acid 92g, add distilled water 27540g, acrylate copolymer 1836g, dissolving is B component; B component slowly adds among the component A, stirs, and coating, compound with protecting film, cut promptly.
Embodiment 34
A. take off column weight amount proportioning crude drug: Flos Caryophylli 100g, Lignum Aquilariae Resinatum 300g, Fructus Aurantii (parched with bran) 300g, Lignum Santali Albi 180g, Radix Et Rhizoma Rhei 180g, Cortex Magnoliae Officinalis (Rhizoma Zingiberis Recens is processed) 300g, Moschus 9g, Semen Crotonis Pulveratum 120g, Fructus Jujubae (enucleation) 1000g, Rhizoma Chuanxiong 180g are standby;
B. go up ten flavors, Semen Crotonis Pulveratum, Moschus pulverize separately become fine powder; All the other eight flavor medicines decoct with water 2 times, and each 2 hours, collecting decoction filtered, and is condensed into thick paste; In above-mentioned thick paste, add Semen Crotonis Pulveratum, Moschus powder, mixing, standby; Get above-mentioned hybrid medicine powder 2869g, add glycerol 13770g, Al (OH) 3183g, sodium acrylate 2754g mix homogeneously are component A; Get tartaric acid 92g, add distilled water 27540g, acrylate copolymer 1836g, dissolving is B component; B component slowly adds among the component A, stirs, and coating, compound with protecting film, cut promptly.
Embodiment 35
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 300g, Flos Caryophylli 100g, Fructus Aurantii (parched with bran) 200g, Lignum Santali Albi 180g, Radix Et Rhizoma Rhei 180g, Cortex Magnoliae Officinalis (Rhizoma Zingiberis Recens is processed) 300g, Moschus 9g, Semen Crotonis Pulveratum 120g, Fructus Jujubae (enucleation) 1000g, Rhizoma Chuanxiong 180g are standby;
B. above ten flavor medicines, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is standby; Flos Caryophylli, the Radix Aucklandiae, Lignum Santali Albi, Fructus Aurantii, Cortex Magnoliae Officinalis, Rhizoma Chuanxiong, Radix Et Rhizoma Rhei powder are broken into 40 purpose powder, CO 2Supercritical extraction, extracting pressure 5MPa, 35 ℃ of temperature, CO 2Flow velocity 20L/h, extraction 2h; Get extract, add an amount of anhydrous alcohol solution,, adopt polishing to carry out enclose,, promptly get clathrate in 40 ℃ of vacuum dryings with an amount of β-CD, standby; Medicinal residues behind the above-mentioned supercritical extraction are added 60% ethanol extraction secondary, merge secondary filtrate, relative density is that 1.25-1.30 is standby when reclaiming ethanol to 60 ℃; Get Fructus Jujubae and decoct with water secondary, each 2h filters; Merging filtrate, relative density 1.25-1.30 when being concentrated into 60 ℃, with above-mentioned alcohol extract condensed cream mixing, drying is ground into fine powder, with clathrate, Semen Crotonis Pulveratum, the Moschus mixing that sieves, crosses 80 mesh sieves again, and is standby; Get carbomer 108g, add water 9000g and stir, NaOH regulates pH to 7, adds above-mentioned hybrid medicine powder 2869g, grinds evenly, promptly.
Embodiment 36
A. take off column weight amount proportioning crude drug: Flos Caryophylli 150g, Lignum Aquilariae Resinatum 300g, Fructus Aurantii (parched with bran) 250g, Lignum Santali Albi 180g, Radix Et Rhizoma Rhei 180g, Cortex Magnoliae Officinalis (Rhizoma Zingiberis Recens is processed) 300g, artificial Moschus 9g, Semen Crotonis Pulveratum 120g, Fructus Jujubae (enucleation) 1200g, Rhizoma Chuanxiong 180g are standby;
B. above ten flavor medicines, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is standby; Flos Caryophylli, Lignum Aquilariae Resinatum, Lignum Santali Albi, Fructus Aurantii, Cortex Magnoliae Officinalis, Rhizoma Chuanxiong, Radix Et Rhizoma Rhei powder are broken into 80 purpose powder, CO 2Supercritical extraction, extracting pressure 40MPa, 60 ℃ of temperature, CO 2Flow velocity 35L/h, extraction 5h; Get extract, add an amount of anhydrous alcohol solution,, adopt polishing to carry out enclose,, promptly get clathrate in 40 ℃ of vacuum dryings with an amount of β-CD, standby; Medicinal residues behind the above-mentioned supercritical extraction are added 60% ethanol extraction secondary, merge secondary filtrate, relative density is that 1.25-1.30 is standby when reclaiming ethanol to 60 ℃; Get Fructus Jujubae and decoct with water secondary, each 2h filters; Merging filtrate, relative density 1.25-1.30 when being concentrated into 60 ℃, with above-mentioned alcohol extract condensed cream mixing, drying is ground into fine powder, with clathrate, Semen Crotonis Pulveratum, the Moschus mixing that sieves, crosses 80 mesh sieves again, and is standby; Get carbomer 158g, add water 8000g and stir, NaOH regulates pH to 7, adds above-mentioned hybrid medicine powder 1869g, grinds evenly, promptly.
Embodiment 37
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 300g, Flos Caryophylli 50g, Fructus Aurantii 300g, Lignum Santali Albi 180g, Radix Et Rhizoma Rhei 180g, Cortex Magnoliae Officinalis 300g, Moschus 9g, Semen Crotonis Pulveratum 120g, Fructus Jujubae 1000g, Rhizoma Chuanxiong 180g are standby;
B. above ten flavor medicines, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is standby; Six-element medicated powder such as Flos Caryophylli, the Radix Aucklandiae, Lignum Santali Albi, Fructus Aurantii, Cortex Magnoliae Officinalis, Rhizoma Chuanxiong are broken into coarse powder, add 16 times of water gagings, soak 4 hours, and decocting boils distillation 8h altogether, collects volatile oil, and is with after β-CD inclusion, standby; Decocting liquid filters, and relative density 1.25-1.30 was standby when filtrate was concentrated into 60 ℃, and medicinal residues and Radix Et Rhizoma Rhei coarse powder add 70% alcohol reflux 2 times, for the first time 2h; 1h filters for the second time; Merge secondary filtrate, relative density 1.20-1.25 when being concentrated into 60 ℃, drying, standby; Get Fructus Jujubae, add decocting and boil secondary, each 2h filters; Merge secondary filtrate, relative density 1.28-1.32 when being concentrated into 60 ℃, drying, with the above-mentioned fine powder that is dried and crushed into,, standby with Semen Crotonis Pulveratum, Moschus mixing; Get carbomer 88g, add water 10000g and stir, NaOH regulates pH to 7, adds above-mentioned hybrid medicine powder 2500g, grinds evenly, promptly.
Embodiment 38
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 300g, Flos Caryophylli 80g, Fructus Aurantii 200g, Lignum Santali Albi 180g, Radix Et Rhizoma Rhei 180g, Cortex Magnoliae Officinalis 300g, Moschus 9g, Semen Crotonis Pulveratum 120g, Fructus Jujubae 1000g, Rhizoma Chuanxiong 180g are standby;
B. above ten flavors, Semen Crotonis Pulveratum, Moschus pulverize separately become fine powder; All the other eight flavor medicines decoct with water 2 times, and each 2 hours, collecting decoction filtered, and is condensed into thick paste; In above-mentioned thick paste, add Semen Crotonis Pulveratum, Moschus powder, mixing, standby; Get carbomer 85g, add water 7500g and stir, NaOH regulates pH to 7, adds above-mentioned hybrid medicine powder 2059g, grinds evenly, promptly.
Embodiment 39
A. take off column weight amount proportioning crude drug: Flos Caryophylli 50g, Lignum Aquilariae Resinatum 350g, Fructus Aurantii (parched with bran) 350g, Lignum Santali Albi 200g, Radix Et Rhizoma Rhei 200g, Cortex Magnoliae Officinalis (Rhizoma Zingiberis Recens is processed) 300g, artificial Moschus 7g, Semen Crotonis Pulveratum 120g, Fructus Jujubae (enucleation) 1000g, Rhizoma Chuanxiong 200g are standby;
B. above ten flavor medicines, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is standby; Flos Caryophylli, the Radix Aucklandiae, Lignum Santali Albi, Fructus Aurantii, Cortex Magnoliae Officinalis, Rhizoma Chuanxiong, Radix Et Rhizoma Rhei powder are broken into 50 purpose powder, CO 2Supercritical extraction, extracting pressure 20MPa, 55 ℃ of temperature, CO 2Flow velocity 25L/h, extraction 3h; Get extract, add an amount of anhydrous alcohol solution,, adopt polishing to carry out enclose,, promptly get clathrate in 40 ℃ of vacuum dryings with an amount of β-CD, standby; Medicinal residues behind the above-mentioned supercritical extraction are added 60% ethanol extraction secondary, merge secondary filtrate, relative density is that 1.25-1.30 is standby when reclaiming ethanol to 60 ℃; Get Fructus Jujubae and decoct with water secondary, each 2h filters; Merging filtrate, relative density 1.25-1.30 when being concentrated into 60 ℃, with above-mentioned alcohol extract condensed cream mixing, drying is ground into fine powder, with clathrate, Semen Crotonis Pulveratum, the Moschus mixing that sieves, crosses 80 mesh sieves again, and is standby; Get carbomer 188g, add water 14000g and stir, NaOH regulates pH to 7, adds above-mentioned hybrid medicine powder 1800g, grinds evenly, promptly.
Embodiment 40
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 150g, Flos Caryophylli 150g, Fructus Aurantii 150g, Lignum Santali Albi 90g, Radix Et Rhizoma Rhei 90g, Cortex Magnoliae Officinalis 150g, Moschus 4.5g, Semen Crotonis Pulveratum 60g, Fructus Jujubae 500g, Rhizoma Chuanxiong 90g are standby;
B. above ten flavor medicines, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is standby; Flos Caryophylli, the Radix Aucklandiae, Lignum Santali Albi, Fructus Aurantii, Cortex Magnoliae Officinalis, Rhizoma Chuanxiong, Radix Et Rhizoma Rhei powder are broken into 40-80 purpose powder, CO 2Supercritical extraction, extracting pressure 15MPa, 40 ℃ of temperature, CO 2Flow velocity 22L/h, extraction 2.5h; Get extract, add an amount of anhydrous alcohol solution,, adopt polishing to carry out enclose,, promptly get clathrate in 40 ℃ of vacuum dryings with an amount of β-CD, standby; Medicinal residues behind the above-mentioned supercritical extraction are added 60% ethanol extraction secondary, merge secondary filtrate, relative density is that 1.25-1.30 is standby when reclaiming ethanol to 60 ℃; Get Fructus Jujubae and decoct with water secondary, each 2h filters; Merging filtrate, relative density 1.25-1.30 when being concentrated into 60 ℃, with above-mentioned alcohol extract condensed cream mixing, drying is ground into fine powder, with clathrate, Semen Crotonis Pulveratum, the Moschus mixing that sieves, crosses 80 mesh sieves again, and is standby; Get above-mentioned hybrid medicine powder 1000g, fat-soluble ointment base 4000g is heated to 60 ℃ of mix homogeneously, is stirred to room temperature, promptly.
Embodiment 41
A. take off column weight amount proportioning crude drug: Flos Caryophylli 100g, Lignum Aquilariae Resinatum 600g, Fructus Aurantii 600g, Lignum Santali Albi 360g, Radix Et Rhizoma Rhei 360g, Cortex Magnoliae Officinalis 600g, Moschus 18g, Semen Crotonis Pulveratum 240g, Fructus Jujubae 2000g, Rhizoma Chuanxiong 360g are standby;
B. above ten flavor medicines, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is standby; Flos Caryophylli, Lignum Aquilariae Resinatum, Lignum Santali Albi, Fructus Aurantii, Cortex Magnoliae Officinalis, Rhizoma Chuanxiong, Radix Et Rhizoma Rhei powder are broken into 75 purpose powder, CO 2Supercritical extraction, extracting pressure 35MPa, 55 ℃ of temperature, CO 2Flow velocity 30L/h, extraction 4h; Get extract, add an amount of anhydrous alcohol solution,, adopt polishing to carry out enclose,, promptly get clathrate in 40 ℃ of vacuum dryings with an amount of β-CD, standby; Medicinal residues behind the above-mentioned supercritical extraction are added 60% ethanol extraction secondary, merge secondary filtrate, relative density is that 1.25-1.30 is standby when reclaiming ethanol to 60 ℃; Get Fructus Jujubae and decoct with water secondary, each 2h filters; Merging filtrate, relative density 1.25-1.30 when being concentrated into 60 ℃, with above-mentioned alcohol extract condensed cream mixing, drying is ground into fine powder, with clathrate, Semen Crotonis Pulveratum, the Moschus mixing that sieves, crosses 80 mesh sieves again, and is standby; Get above-mentioned hybrid medicine powder 3500g, PEG 40015000g and poloxamer 1500g are heated to 80 ℃ of mix homogeneously, are stirred to room temperature, promptly.
Embodiment 42
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 200g, Flos Caryophylli 150g, Fructus Aurantii 600g, Lignum Santali Albi 360g, Radix Et Rhizoma Rhei 90g, Cortex Magnoliae Officinalis 200g, Moschus 10g, Semen Crotonis Pulveratum 80g, Fructus Jujubae 1500g, Rhizoma Chuanxiong 300g are standby;
B. above ten flavor medicines, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is standby; Six-element medicated powder such as Flos Caryophylli, the Radix Aucklandiae, Lignum Santali Albi, Fructus Aurantii, Cortex Magnoliae Officinalis, Rhizoma Chuanxiong are broken into coarse powder, add 16 times of water gagings, soak 4 hours, and decocting boils distillation 8h altogether, collects volatile oil, and is with after β-CD inclusion, standby; Decocting liquid filters, and relative density 1.25-1.30 was standby when filtrate was concentrated into 60 ℃, and medicinal residues and Radix Et Rhizoma Rhei coarse powder add 70% alcohol reflux 2 times, for the first time 2h; 1h filters for the second time; Merge secondary filtrate, relative density 1.20-1.25 when being concentrated into 60 ℃, drying, standby; Get Fructus Jujubae, add decocting and boil secondary, each 2h filters; Merge secondary filtrate, relative density 1.28-1.32 when being concentrated into 60 ℃, drying, with the above-mentioned fine powder that is dried and crushed into,, standby with Semen Crotonis Pulveratum, Moschus mixing; Get above-mentioned hybrid medicine powder 2000g, fat-soluble ointment base 10000g is heated to 60 ℃ of mix homogeneously, is stirred to room temperature, promptly.
Embodiment 43
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 250g, Lignum Aquilariae Resinatum 250g, Fructus Aurantii 250g, Lignum Santali Albi 150g, Radix Et Rhizoma Rhei 250g, Cortex Magnoliae Officinalis 250g, Moschus 6g, Semen Crotonis Pulveratum 100g, Fructus Jujubae 800g, Rhizoma Chuanxiong 150g are standby;
B. above ten flavors, Semen Crotonis Pulveratum, Moschus pulverize separately become fine powder; All the other eight flavor medicines decoct with water 2 times, and each 2 hours, collecting decoction filtered, and is condensed into thick paste; In above-mentioned thick paste, add Semen Crotonis Pulveratum, Moschus powder, mixing, standby; Get above-mentioned hybrid medicine powder 1500g, PEG 4003000g and poloxamer 2000g are heated to 65 ℃ of mix homogeneously, are stirred to room temperature, promptly.
Embodiment 44
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 400g, Flos Caryophylli 50g, Fructus Aurantii 400g, Lignum Santali Albi 250g, Radix Et Rhizoma Rhei 250g, Cortex Magnoliae Officinalis 400g, Moschus 12g, Semen Crotonis Pulveratum 150g, Fructus Jujubae 1200g, Rhizoma Chuanxiong 250g are standby;
B. above ten flavor medicines, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is standby; Six-element medicated powder such as Flos Caryophylli, the Radix Aucklandiae or Lignum Aquilariae Resinatum, Lignum Santali Albi, Fructus Aurantii, Cortex Magnoliae Officinalis, Rhizoma Chuanxiong are broken into coarse powder, add 8 times of water gagings, soak 3 hours, and decocting boils distillation 8h altogether, collects volatile oil, and is with after β-CD inclusion, standby; Decocting liquid filters, and relative density 1.25-1.30 was standby when filtrate was concentrated into 50 ℃, and medicinal residues and Radix Et Rhizoma Rhei coarse powder add 60% alcohol reflux 2 times, for the first time 2h; 1h filters for the second time; Merge secondary filtrate, relative density 1.20-1.25 when being concentrated into 60 ℃, drying, standby; Get Fructus Jujubae, add decocting and boil secondary, each 2h filters; Merge secondary filtrate, relative density 1.28-1.32 when being concentrated into 50 ℃, drying, with the above-mentioned fine powder that is dried and crushed into, with Semen Crotonis Pulveratum, Moschus mixing, sieving is component A; Octadecanol 750g, white vaseline 750g, ethyl hydroxybenzoate 7g are heated to 80 ℃ and are molten into B component; Get sodium lauryl sulphate 70g, add glycerol 700g, water 10000g dissolving, be component C; Component C is slowly added in the B component, continue to stir, add component A when being cooled to 40 ℃, fully stir, be condensed to and partly solidify shape, promptly.
Embodiment 45
A. take off column weight amount proportioning crude drug: Flos Caryophylli 180g, Lignum Aquilariae Resinatum 300g, Fructus Aurantii (parched with bran) 300g, Lignum Santali Albi 180g, Radix Et Rhizoma Rhei 180g, Cortex Magnoliae Officinalis (Rhizoma Zingiberis Recens is processed) 300g, Moschus 9g, Semen Crotonis Pulveratum 120g, Fructus Jujubae (enucleation) 1000g, Rhizoma Chuanxiong 180g are standby;
B. above ten flavor medicines, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is standby; Flos Caryophylli, Lignum Aquilariae Resinatum, Lignum Santali Albi, Fructus Aurantii, Cortex Magnoliae Officinalis, Rhizoma Chuanxiong, Radix Et Rhizoma Rhei powder are broken into 60 purpose powder, CO 2Supercritical extraction, extracting pressure 10MPa, 35 ℃ of temperature, CO 2Flow velocity 20L/h, extraction 3h; Get extract, add an amount of anhydrous alcohol solution,, adopt polishing to carry out enclose,, promptly get clathrate in 40 ℃ of vacuum dryings with an amount of β-CD, standby; Medicinal residues behind the above-mentioned supercritical extraction are added 60% ethanol extraction secondary, merge secondary filtrate, relative density is that 1.25-1.30 is standby when reclaiming ethanol to 60 ℃; Get Fructus Jujubae and decoct with water secondary, each 2h filters; Merging filtrate, relative density 1.25-1.30 when being concentrated into 60 ℃, with above-mentioned alcohol extract condensed cream mixing, drying is ground into fine powder, with clathrate, Semen Crotonis Pulveratum, the Moschus mixing that sieves, crosses 80 mesh sieves again, and is standby; Get above-mentioned hybrid medicine powder 2869g, fat-soluble ointment base 9100g is heated to 60 ℃ of mix homogeneously, is stirred to room temperature, promptly.
Embodiment 46
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 250g, Flos Caryophylli 120g, Fructus Aurantii (parched with bran) 250g, Lignum Santali Albi 180g, Radix Et Rhizoma Rhei 180g, Cortex Magnoliae Officinalis (Rhizoma Zingiberis Recens is processed) 300g, Moschus 9g, Semen Crotonis Pulveratum 120g, Fructus Jujubae (enucleation) 1200g, Rhizoma Chuanxiong 180g are standby;
B. above ten flavors, Semen Crotonis Pulveratum, Moschus pulverize separately become fine powder; All the other eight flavor medicines decoct with water 2 times, and each 2 hours, collecting decoction filtered, and is condensed into thick paste; In above-mentioned thick paste, add Semen Crotonis Pulveratum, Moschus powder, mixing, standby; Get above-mentioned hybrid medicine powder 2869g, PEG 4006100g and poloxamer 2900g are heated to 60 ℃ of mix homogeneously, are stirred to room temperature, promptly.
Embodiment 47
A. take off column weight amount proportioning crude drug: Flos Caryophylli 100g, Lignum Aquilariae Resinatum 300g, Fructus Aurantii 200g, Lignum Santali Albi 180g, Radix Et Rhizoma Rhei 180g, Cortex Magnoliae Officinalis 300g, Moschus 9g, Semen Crotonis Pulveratum 120g, Fructus Jujubae 1500g, Rhizoma Chuanxiong 180g are standby;
B. above ten flavors, Semen Crotonis Pulveratum, Moschus pulverize separately become fine powder; All the other eight flavor medicines decoct with water 3 times, and each 3 hours, collecting decoction filtered, and is condensed into thick paste; In above-mentioned thick paste, add Semen Crotonis Pulveratum, Moschus powder, mixing, sieving is component A; Octadecanol 1430g, white vaseline 1430g, ethyl hydroxybenzoate 14.3g are heated to 80 ℃ and are molten into B component; Get sodium lauryl sulphate 143g, add glycerol 1430g, water 5740g dissolving, be component C; Component C is slowly added in the B component, continue to stir, add 2869g component A when being cooled to 40 ℃, fully stir, be condensed to and partly solidify shape, promptly.
Embodiment 48
A. take off column weight amount proportioning crude drug: Flos Caryophylli 300g, Lignum Aquilariae Resinatum 300g, Fructus Aurantii 300g, Lignum Santali Albi 180g, Radix Et Rhizoma Rhei 180g, Cortex Magnoliae Officinalis 300g, Moschus 9g, Semen Crotonis Pulveratum 120g, Fructus Jujubae 1000g, Rhizoma Chuanxiong 180g are standby;
B. above ten flavor medicines, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is standby; Six-element medicated powder such as Flos Caryophylli, Lignum Aquilariae Resinatum, Lignum Santali Albi, Fructus Aurantii, Cortex Magnoliae Officinalis, Rhizoma Chuanxiong are broken into coarse powder, add 16 times of water gagings, soak 4 hours, and decocting boils distillation 8h altogether, collects volatile oil, and is with after β-CD inclusion, standby; Decocting liquid filters, and relative density 1.25-1.30 was standby when filtrate was concentrated into 60 ℃, and medicinal residues and Radix Et Rhizoma Rhei coarse powder add 70% alcohol reflux 2 times, for the first time 2h; 1h filters for the second time; Merge secondary filtrate, relative density 1.20-1.25 when being concentrated into 60 ℃, drying, standby; Get Fructus Jujubae, add decocting and boil secondary, each 2h filters; Merge secondary filtrate, relative density 1.28-1.32 when being concentrated into 60 ℃, drying, with the above-mentioned fine powder that is dried and crushed into, with Semen Crotonis Pulveratum, Moschus mixing, sieving is component A; Octadecanol 1230g, white vaseline 1330g, ethyl hydroxybenzoate 12g are heated to 90 ℃ and are molten into B component; Get sodium lauryl sulphate 120g, add glycerol 1200g, water 6740g dissolving, be component C; Component C is slowly added in the B component, continue to stir, add 2000g component A when being cooled to 40 ℃, fully stir, be condensed to and partly solidify shape, promptly.
Embodiment 49
A. take off column weight amount proportioning crude drug: Flos Caryophylli 100g, Radix Aucklandiae 300g, Fructus Aurantii 300g, Lignum Santali Albi 180g, Radix Et Rhizoma Rhei 180g, Cortex Magnoliae Officinalis 300g, Moschus 9g, Semen Crotonis Pulveratum 120g, Fructus Jujubae 1000g and Rhizoma Chuanxiong 180g are standby;
B. above ten flavors, Semen Crotonis Pulveratum, Moschus pulverize separately become fine powder; All the other tasty fine powders that are ground into, with Semen Crotonis Pulveratum, Moschus powder facing-up, mixing sieves, and is standby; Use water pill, cold drying, promptly.
Embodiment 50
A. take off column weight amount proportioning crude drug: Flos Caryophylli 100g, Lignum Aquilariae Resinatum 300g, Fructus Aurantii 300g, Lignum Santali Albi 180g, Radix Et Rhizoma Rhei 180g, Cortex Magnoliae Officinalis 300g, Moschus 9g, Semen Crotonis Pulveratum 120g, Fructus Jujubae 1000g and Rhizoma Chuanxiong 180g are standby;
B. above ten flavors, Semen Crotonis Pulveratum, Moschus pulverize separately become fine powder; All the other eight flavors are ground into fine powder, and with Semen Crotonis Pulveratum, Moschus powder facing-up, mixing sieves, and is standby; Use water pill, cold drying, promptly.

Claims (9)

1. treat the gastrointestinal disease Chinese medicine composition for one kind, it is characterized in that it being to make by following weight proportioning raw material:
Flos Caryophylli 50～200g, the Radix Aucklandiae or Lignum Aquilariae Resinatum 150～600g, Fructus Aurantii 150～600g, Lignum Santali Albi 90～360g, Radix Et Rhizoma Rhei 90～360g, Cortex Magnoliae Officinalis 150～600g, Moschus 4.5～18g, Semen Crotonis Pulveratum 60～240g, Fructus Jujubae 500～2000g and Rhizoma Chuanxiong 90～360g.
2. the described treatment gastrointestinal disease of claim 1 Chinese medicine composition is characterized in that it being to be made by following weight proportioning raw material:
Flos Caryophylli 80～150g, the Radix Aucklandiae or Lignum Aquilariae Resinatum 250～400g, Fructus Aurantii 200～400g, Lignum Santali Albi 150～250g, Radix Et Rhizoma Rhei 150～250g, Cortex Magnoliae Officinalis 250～400g, Moschus 6～12g, Semen Crotonis Pulveratum 100～150g, Fructus Jujubae 800～1200g and Rhizoma Chuanxiong 150～250g.
3. the described treatment gastrointestinal disease of claim 2 Chinese medicine composition is characterized in that it being to be made by following weight proportioning raw material:
Flos Caryophylli 100g, the Radix Aucklandiae or Lignum Aquilariae Resinatum 300g, Fructus Aurantii 300g, Lignum Santali Albi 180g, Radix Et Rhizoma Rhei 180g, Cortex Magnoliae Officinalis 300g, Moschus 9g, Semen Crotonis Pulveratum 120g, Fructus Jujubae 1000g and Rhizoma Chuanxiong 180g.
4. the arbitrary described treatment gastrointestinal disease Chinese medicine composition of claim 1～3 is characterized in that Fructus Aurantii is a stir-baked Fructus Aurantii in bran; Cortex Magnoliae Officinalis is a Cortex Magnoliae Officinalis (processed with ginger); Fructus Jujubae is that Fructus Jujubae, the Moschus of enucleation is the artificial Moschus.
5. the preparation method of the arbitrary described treatment gastrointestinal disease Chinese medicine composition of claim 1～3 is characterized in that:
A. take off and state the weight proportion crude drug: Flos Caryophylli, the Radix Aucklandiae or Lignum Aquilariae Resinatum, Fructus Aurantii, Lignum Santali Albi, Radix Et Rhizoma Rhei, Cortex Magnoliae Officinalis, Moschus, Semen Crotonis Pulveratum, Fructus Jujubae and Rhizoma Chuanxiong are standby;
B. above ten flavor medicines, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is standby; Flos Caryophylli, the Radix Aucklandiae or Lignum Aquilariae Resinatum, Lignum Santali Albi, Fructus Aurantii, Cortex Magnoliae Officinalis, Rhizoma Chuanxiong, Radix Et Rhizoma Rhei are pulverized CO 2Supercritical extraction; Get extract, add an amount of anhydrous alcohol solution, carry out enclose with an amount of β-CD, drying promptly gets clathrate, and is standby; With the medicinal residues ethanol extraction secondary behind the above-mentioned supercritical extraction, merge secondary filtrate, reclaim ethanol and concentrate standby; Get Fructus Jujubae and decoct with water secondary, filter; Merging filtrate concentrates, and with above-mentioned alcohol extract condensed cream mixing, drying is ground into fine powder, with clathrate, Semen Crotonis Pulveratum, the Moschus mixing that sieves, sieves again, and is standby;
Perhaps above ten flavor medicines, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is standby; Six-element medicated powder such as Flos Caryophylli, the Radix Aucklandiae or Lignum Aquilariae Resinatum, Lignum Santali Albi, Fructus Aurantii, Cortex Magnoliae Officinalis, Rhizoma Chuanxiong are broken into coarse powder, add water, soak, and decocting boils distillation, collect volatile oil, and are with after β-CD inclusion, standby; Decocting liquid filters, and filtrate concentrates standby, and medicinal residues and Radix Et Rhizoma Rhei coarse powder add alcohol reflux 2 times, filters; Merge secondary filtrate, concentrate, drying, standby; Get Fructus Jujubae, add decocting and boil secondary, filter; Merge secondary filtrate, concentrate, drying, the above-mentioned fine powder that is dried and crushed into, with Semen Crotonis Pulveratum, Moschus mixing, standby;
Perhaps above ten flavors, Semen Crotonis Pulveratum, Moschus pulverize separately become fine powder; All the other eight flavor medicines decoct with water 1～3 time, and each 1～3 hour, collecting decoction filtered, and is condensed into thick paste; In above-mentioned thick paste, add Semen Crotonis Pulveratum, Moschus powder, mixing, standby;
Perhaps above ten flavors, Semen Crotonis Pulveratum, Moschus pulverize separately become fine powder; All the other eight flavors are ground into fine powder, and with Semen Crotonis Pulveratum, Moschus powder facing-up, mixing sieves, and is standby;
C. the active component that step b is obtained is made preparation.
6. the preparation method of the described treatment gastrointestinal disease of claim 5 Chinese medicine composition is characterized in that:
A. take off and state the weight proportion crude drug: Flos Caryophylli, the Radix Aucklandiae or Lignum Aquilariae Resinatum, Fructus Aurantii, Lignum Santali Albi, Radix Et Rhizoma Rhei, Cortex Magnoliae Officinalis, Moschus, Semen Crotonis Pulveratum, Fructus Jujubae and Rhizoma Chuanxiong are standby;
B. above ten flavor medicines, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is standby; Flos Caryophylli, the Radix Aucklandiae or Lignum Aquilariae Resinatum, Lignum Santali Albi, Fructus Aurantii, Cortex Magnoliae Officinalis, Rhizoma Chuanxiong, Radix Et Rhizoma Rhei powder are broken into 40-80 purpose powder, CO 2Supercritical extraction, extracting pressure 5-40MPa, temperature 35-60 ℃, CO 2Flow velocity 20-35L/h, extraction 2-5h; Get extract, add an amount of anhydrous alcohol solution,, adopt polishing to carry out enclose,, promptly get clathrate in 40 ℃ of vacuum dryings with an amount of β-CD, standby; Medicinal residues behind the above-mentioned supercritical extraction are added 60% ethanol extraction secondary, merge secondary filtrate, relative density is that 1.25-1.30 is standby when reclaiming ethanol to 60 ℃; Get Fructus Jujubae and decoct with water secondary, each 2h filters; Merging filtrate, relative density 1.25-1.30 when being concentrated into 60 ℃, with above-mentioned alcohol extract condensed cream mixing, drying is ground into fine powder, with clathrate, Semen Crotonis Pulveratum, the Moschus mixing that sieves, crosses 80 mesh sieves again, and is standby;
Perhaps above ten flavor medicines, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is standby; Six-element medicated powder such as Flos Caryophylli, the Radix Aucklandiae or Lignum Aquilariae Resinatum, Lignum Santali Albi, Fructus Aurantii, Cortex Magnoliae Officinalis, Rhizoma Chuanxiong are broken into coarse powder, add 16 times of water gagings, soak 4 hours, and decocting boils distillation 8h altogether, collects volatile oil, and is with after β-CD inclusion, standby; Decocting liquid filters, and relative density 1.25-1.30 was standby when filtrate was concentrated into 60 ℃, and medicinal residues and Radix Et Rhizoma Rhei coarse powder add 70% alcohol reflux 2 times, for the first time 2h; 1h filters for the second time; Merge secondary filtrate, relative density 1.20-1.25 when being concentrated into 60 ℃, drying, standby; Get Fructus Jujubae, add decocting and boil secondary, each 2h filters; Merge secondary filtrate, relative density 1.28-1.32 when being concentrated into 60 ℃, drying, with the above-mentioned fine powder that is dried and crushed into,, standby with Semen Crotonis Pulveratum, Moschus mixing;
Perhaps above ten flavors, Semen Crotonis Pulveratum, Moschus pulverize separately become fine powder; All the other eight flavor medicines decoct with water 2 times, and each 2 hours, collecting decoction filtered, and is condensed into thick paste; In above-mentioned thick paste, add Semen Crotonis Pulveratum, Moschus powder, mixing, standby;
Perhaps above ten flavors, Semen Crotonis Pulveratum, Moschus pulverize separately become fine powder; All the other eight flavors are ground into fine powder, and with Semen Crotonis Pulveratum, Moschus powder facing-up, mixing sieves, and is standby;
C. the active component that step b is obtained is made preparation.
7. the preparation method of the described treatment gastrointestinal disease of claim 6 Chinese medicine composition is characterized in that the preparation among the step c is tablet, granule, honey pill agent, watered pill, drop pill, hard capsule, soft capsule, patch, cataplasma, ointment, gel.
8. the application of the arbitrary described treatment gastrointestinal disease Chinese medicine composition of claim 1～3 in preparation treatment irritable bowel syndrome medicine.
The arbitrary described treatment gastrointestinal disease Chinese medicine composition of claim 1～3 at preparation treatment diarrhoea, poor appetite, feel sick, the application in the vomiting, abdominal distention, stomachache, dyspepsia, dysentery, enteritis, functional gastrointestinal disease medicine.
CN200810154422.9A 2008-12-24 2008-12-24 One treats gastrointestinal disease Chinese medicine composition and preparation method thereof Active CN101757288B (en)

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102178914A (en) * 2011-04-22 2011-09-14 施国俊 Chinese medicinal composition for treating gastrointestinal disease and preparation method thereof
CN104435182A (en) * 2014-11-10 2015-03-25 青岛祥翔生物医药科技有限公司 Traditional Chinese medicine for treating gastrointestinal diseases caused by stomach-yang deficiency
CN111729009A (en) * 2019-03-20 2020-10-02 天津中新药业集团股份有限公司乐仁堂制药厂 Traditional Chinese medicine composition for treating gastrointestinal diseases, application and traditional Chinese medicine compound preparation

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100446793C (en) * 2006-09-27 2008-12-31 天津中新药业集团股份有限公司乐仁堂制药厂 Chinese-medicinal composition for treating enterogastric diseases

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102178914A (en) * 2011-04-22 2011-09-14 施国俊 Chinese medicinal composition for treating gastrointestinal disease and preparation method thereof
CN102178914B (en) * 2011-04-22 2013-03-27 施国俊 Chinese medicinal composition for treating gastrointestinal disease and preparation method thereof
CN104435182A (en) * 2014-11-10 2015-03-25 青岛祥翔生物医药科技有限公司 Traditional Chinese medicine for treating gastrointestinal diseases caused by stomach-yang deficiency
CN104435182B (en) * 2014-11-10 2016-09-07 翁敏芬 A kind of Chinese medicine treating stomach yang deficiency syndrome type gastrointestinal disease
CN111729009A (en) * 2019-03-20 2020-10-02 天津中新药业集团股份有限公司乐仁堂制药厂 Traditional Chinese medicine composition for treating gastrointestinal diseases, application and traditional Chinese medicine compound preparation

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