CN111870649A

CN111870649A - Traditional Chinese medicine composition for treating type II diabetes and preparation method thereof

Info

Publication number: CN111870649A
Application number: CN202010923862.7A
Authority: CN
Inventors: 杨鹏
Original assignee: Individual
Current assignee: Individual
Priority date: 2020-09-04
Filing date: 2020-09-04
Publication date: 2020-11-03

Abstract

The invention belongs to the technical field of traditional Chinese medicines for treating diabetes, and discloses a traditional Chinese medicine composition for treating type II diabetes and a preparation method thereof, wherein the traditional Chinese medicine composition comprises the following raw materials: affine cudweed, lily, spanishneedles herb, anemarrhena and astragalus; wherein the affine cudweed, the lily, the spanishneedles herb, the rhizoma anemarrhenae and the astragalus root are sequentially mixed according to the parts by weight: 20-50 parts of affine cudweed, 10-20 parts of lily, 10-20 parts of spanishneedles herb, 5-15 parts of rhizoma anemarrhenae and 5-15 parts of astragalus membranaceus. On the basis of the research on the pathogenesis of the traditional Chinese medicine and diabetes, the invention takes the affine cudweed as the monarch drug, and reasonably combines the affine cudweed with the lily, the spanishneedles herb, the anemarrhena and the astragalus, thereby playing the role of mutual synergy and having the efficacies of reducing blood sugar and blood fat, excreting dampness and strengthening pulse, dredging yin and softening yang, strengthening spleen and replenishing qi, and regulating qi and removing abdominal mass, thereby obviously improving or relieving the symptoms of the diabetes.

Description

Traditional Chinese medicine composition for treating type II diabetes and preparation method thereof

Technical Field

The invention belongs to the technical field of traditional Chinese medicines for treating diabetes, and particularly relates to a traditional Chinese medicine composition for treating type II diabetes and a preparation method thereof.

Background

Diabetes has become one of the world's public health concerns, with about 4 million people worldwide suffering from diabetes. The prevalence rate of diabetes of natural people in China shows a trend of rising continuously along with the time, and the number of people suffering from diabetes currently is more than 7000 thousands. The goals of diabetes therapy are mainly to stabilize blood sugar close to normal level for a long time, eliminate symptoms, prevent or delay the occurrence of complications, correct metabolic disorders, improve the quality of life of patients, prolong life, and reduce the mortality. At present, most of the medicines for treating diabetes are western medicines. The blood sugar reducing effect of western medicines is definite, but the western medicines need to be taken for life, but adverse reactions are also witnessed, the long-term use of the western medicines can cause the damage of the medicines to a matrix, and certainly, some traditional Chinese medicine preparations also have limited treatment values.

The known efficacy characteristics of the affine cudweed in the traditional Chinese medicine are as follows: has the effects of eliminating phlegm, relieving cough, dispelling pathogenic wind, removing dampness, and removing toxic substances; sweet, slightly sour and neutral in nature; entering lung meridian; can be used for treating cough, asthma, excessive phlegm, rheumatalgia, diarrhea, edema, Vicia faba disease, leucorrhea with red and white discharge, carbuncle, furuncle, pudendum pruritus, urticaria, and hypertension. In the prior art, the utilization of the affine cudweed is the utilization range of the common pharmacology, for example, the affine cudweed is used as a component for preparing a beverage with a health-care function, and the health-care function is realized on the known effect and is applied conventionally.

Disclosure of Invention

In order to solve the problems in the prior art, the invention aims to provide a traditional Chinese medicine composition for treating type II diabetes and a preparation method thereof.

The technical scheme adopted by the invention is as follows:

on the one hand, the traditional Chinese medicine composition for treating type II diabetes is provided, and is characterized by comprising the following raw materials: affine cudweed, lily, spanishneedles herb, anemarrhena and astragalus;

wherein the affine cudweed, the lily, the spanishneedles herb, the rhizoma anemarrhenae and the astragalus root are sequentially mixed according to the parts by weight: 20-50 parts of affine cudweed, 10-20 parts of lily, 10-20 parts of spanishneedles herb, 5-15 parts of rhizoma anemarrhenae and 5-15 parts of astragalus membranaceus.

Preferably, 30 to 45 parts of affine cudweed, 10 to 15 parts of lily, 10 to 15 parts of spanishneedles herb, 5 to 10 parts of rhizoma anemarrhenae and 5 to 10 parts of astragalus membranaceus.

Preferably, the feed comprises the following raw materials in parts by weight: 40 parts of affine cudweed, 15 parts of lily, 15 parts of spanishneedles herb, 10 parts of rhizoma anemarrhenae and 10 parts of astragalus membranaceus.

On the other hand, the preparation method of the traditional Chinese medicine composition for treating type II diabetes is also provided, and the preparation method comprises the following steps:

soaking affine cudweed, lily, spanishneedles herb, common anemarrhena rhizome and astragalus for 25-40 minutes, then decocting with slow fire for 40-60 minutes, and collecting decoction after decoction;

Preferably, the lily is washed with water before soaking, soaked for 7-9 hours, dewatered after soaking to obtain white foam, 1000-2000 ml of water is added, cleaned, cut and dried affine cudweed, sticktight, rhizoma anemarrhenae and astragalus membranaceus are added, the decoction is carried out for two times, the time of each time is 40-60 minutes, and the decoction of the two times is collected. Wherein the water can be mineral water, drinking water or spring water, preferably spring water.

The steps of cleaning, cutting and drying the gnaphalium affine, the spanishneedles herb, the anemarrhena asphodeloides bunge and the astragalus mongholicus need to be selected according to whether the used medicinal materials are finished products or not.

Preferably, the traditional Chinese medicine comprises 40 parts of affine cudweed, 15 parts of lily, 15 parts of spanishneedles herb, 10 parts of rhizoma anemarrhenae and 10 parts of astragalus membranaceus.

Diabetes is mostly caused by diabetes, and its basic pathogenesis is yin and body fluid consumption and predominant dry heat. Long-term diabetes leads to yin deficiency involving yang, heat scorching body fluid and blood stasis, which leads to yin-yang deficiency, qi-yin deficiency, collateral obstruction and malnutrition of meridians.

In the pharmaceutical composition of the invention, the used traditional Chinese medicine raw materials are all natural medicines commonly seen in the field, and the sources and the efficacies of the traditional Chinese medicines are as follows:

affine cudweed: has the effects of eliminating phlegm, relieving cough, dispelling pathogenic wind, removing dampness, and removing toxic substances; sweet, slightly sour and neutral in nature; entering lung meridian; can be used for treating cough, asthma, excessive phlegm, rheumatalgia, diarrhea, edema, Vicia faba disease, leucorrhea with red and white discharge, carbuncle, furuncle, pudendum pruritus, urticaria, and hypertension.

Bidens pilosa L: warm in nature, bitter in taste and non-toxic; has effects of clearing away heat and toxic materials, removing blood stasis, and relieving swelling. Can be used for treating diarrhea, dysentery, hepatitis, acute nephritis, gastralgia, intestinal carbuncle, laryngopharynx swelling and pain, traumatic injury, and snake and insect bite.

Lily: sweet in flavor and cold in nature. Has the effects of nourishing yin, moistening lung, clearing away heart-fire and tranquilizing mind. It is commonly indicated for dry cough due to yin deficiency, cough with blood, restlessness and pavor due to deficiency, insomnia and dreaminess, absentmindedness.

Rhizoma anemarrhenae: bitter and cold. It enters lung, stomach and kidney meridians. Has the effects of clearing heat, purging fire, nourishing yin and moistening dryness. Can be used for treating fever polydipsia, lung heat dry cough, hectic fever due to yin-deficiency, internal heat diabetes, and constipation due to intestinal dryness.

In the traditional Chinese medicine formula, the affine cudweed is used as a monarch drug and is reasonably compatible with the lily, the spanishneedles herb, the rhizoma anemarrhenae and the astragalus, so that the effects of mutually cooperating can be achieved, and the efficacies of reducing blood sugar and blood fat, excreting dampness and strengthening pulse, dredging yin and softening yang, strengthening spleen and replenishing qi, and regulating qi and removing stuffiness are achieved, so that the symptoms of diabetes can be obviously improved or relieved.

In addition to the steps of the preparation method, the decoction prepared by the method can be filtered, the filtrate is decompressed and concentrated into clear paste, then the clear paste is filtered through a 400-mesh sieve while the clear paste is hot, the filtered paste is sprayed and dried to obtain spray dry powder, and pharmaceutically acceptable auxiliary materials can be optionally added into the obtained spray dry powder to prepare pills, tablets, capsules, dripping pills, powder, granules and oral liquid, without limitation.

The invention has the beneficial effects that:

the affine cudweed of the traditional Chinese medicine composition is not recorded in the existing patent documents and Chinese medical books and Chinese herbal medicine researches on the traditional Chinese medicine for treating hyperglycemia and blood fat; the applicant unexpectedly discovers that the traditional Chinese medicine has remarkable effects on treating hyperglycemia and blood fat in the long-term use process, and the results of the long-term cooperation of patients with target diseases prove that the blood sugar and the blood fat of the patients are remarkably reduced, and the effects of the patients on treating the hyperglycemia and the blood fat are definite, so that the traditional Chinese medicine composition with the affine cudweed for treating the type II diabetes is provided by combining the discovery and further research of the applicant.

On the basis of the research on the pathogenesis of the traditional Chinese medicine and diabetes, the affine cudweed with the efficacy of reducing blood fat and blood sugar is taken as the monarch drug, and the monarch drug is scientifically and reasonably compatible with the lily, the spanishneedles herb, the rhizoma anemarrhenae and the astragalus root, so that the traditional Chinese medicine can play a role of mutual synergy, and has the efficacy of reducing blood fat and blood sugar, excreting dampness and strengthening pulse, dredging yin and softening yang, strengthening spleen and supplementing qi, regulating qi and removing stuffiness, so that the effects of reducing blood fat and blood sugar are more prominent, and the symptoms of diabetes can be obviously improved or relieved.

In addition, the method for preparing the traditional Chinese medicine composition has the advantages of common raw materials, simple steps and convenience in popularization and preparation.

Detailed Description

The present invention is further illustrated below with reference to specific examples.

Example 1:

taking 20 parts of affine cudweed, 10 parts of lily, 10 parts of spanishneedles herb, 5 parts of rhizoma anemarrhenae and 5 parts of astragalus root.

Mixing the traditional Chinese medicines, soaking for 25 minutes, then decocting with slow fire for 40 minutes, and collecting decoction after decoction to obtain decoction, namely the traditional Chinese medicine composition liquid medicine for treating type II diabetes. The lily can be soaked according to the actual concrete conditions of the medicinal materials, the lily is washed by water before being soaked, then soaked for 7 hours, the water is removed after the white foam is soaked, 1000ml of the water is added, and then other traditional Chinese medicines are added and decocted.

Example 2:

taking 30 parts of affine cudweed, 15 parts of lily, 15 parts of spanishneedles herb, 10 parts of rhizoma anemarrhenae and 10 parts of astragalus root.

Mixing the traditional Chinese medicines, soaking for 30 minutes, then decocting with slow fire for 50 minutes, and collecting decoction after decoction to obtain decoction, namely the traditional Chinese medicine composition liquid medicine for treating type II diabetes. The lily can be soaked according to the actual concrete conditions of the medicinal materials, the lily is washed by water before being soaked, then is soaked for 8 hours, water is removed after the white foam is soaked, 1500ml of water is added, and other traditional Chinese medicines are added and decocted.

Example 3:

taking 50 parts of affine cudweed, 20 parts of lily, 20 parts of spanishneedles herb, 15 parts of rhizoma anemarrhenae and 15 parts of astragalus root.

Mixing the traditional Chinese medicines, soaking for 40 minutes, then decocting with slow fire for 60 minutes, and collecting decoction after decoction to obtain decoction, namely the traditional Chinese medicine composition liquid medicine for treating type II diabetes. The lily can be soaked according to the actual concrete conditions of the medicinal materials, the lily is washed by water before being soaked, then soaked for 9 hours, the water is removed after the white foam is soaked, 2000ml of water is added, and then other traditional Chinese medicines are added and decocted.

Example 4:

taking 40 parts of affine cudweed, 15 parts of lily, 15 parts of spanishneedles herb, 10 parts of rhizoma anemarrhenae and 10 parts of astragalus root.

Mixing the traditional Chinese medicines, soaking for 30 minutes, then decocting with slow fire for 60 minutes, and collecting decoction after decoction to obtain decoction, namely the traditional Chinese medicine composition liquid medicine for treating type II diabetes. The lily can be soaked according to the actual concrete conditions of the medicinal materials. And washing Bulbus Lilii with water before soaking, soaking for 7 hr, removing water after soaking to obtain rhizoma Melastomatis Canadensis, adding 2000ml, and decocting other Chinese medicinal materials.

Example 5:

taking 40 parts of affine cudweed, 15 parts of lily, 15 parts of spanishneedles herb, 10 parts of rhizoma anemarrhenae and 10 parts of astragalus membranaceus.

In the embodiment, the affine cudweed of the affine cudweed genus is adopted, and long-term research of the applicant proves that the affine cudweed has better effect of treating hyperlipidemia and blood sugar.

Test example 1: the animal model has the treatment effect that the traditional Chinese medicine composition has influence on hyperglycemia and hyperlipidemia induced by obesity

24 Wistar rats (100-120 g) are selected, fed with high-fat diet for 30 days, then fasted without water prohibition for 20 days, an obese hyperglycemia and hyperlipemia rat model is established, 6 rats in each group are randomly divided into 4 groups, namely 6ml/100g of a traditional Chinese medicine large dose group, 3ml/100g of a traditional Chinese medicine medium dose group, 1ml/100g of a traditional Chinese medicine small dose group and 6ml/100g of model group PBS (PBS), and the rats are gavaged for 1 time every day, and meanwhile, 6 Wistar rats are used as normal controls. Collecting blood from tail vein before and after intragastric administration at 21 st and 42 th days, and detecting blood sugar and blood cholesterol content.

The results show that after the gavage day 21 of the traditional Chinese medicine large-dose group and the traditional Chinese medicine medium-dose group, the contents of blood sugar and cholesterol are obviously reduced, and the levels of the blood sugar and the cholesterol are equivalent to those of the normal group on the gavage day 42. The Chinese medicinal composition is suggested to obviously reduce the blood sugar level and the cholesterol level of rats induced by obesity, and the blood sugar level and the cholesterol level are shown in tables 1 and 2.

TABLE 1 Effect of Chinese medicinal composition on obesity induced hyperlipidemia in rats

Pre-and post-treatment glycemia P < 0.05; comparison of pre-and post-treatment glycemia P <0.01

TABLE 2 Effect of Chinese medicinal composition on obesity induced hyperlipidemia in rats

Test example 2: typical pathology, observation of blood sugar lowering effect of traditional Chinese medicine composition on type II diabetes patients

60 patients with type II diabetes are selected, 20 patients in each group are randomly divided into a metformin treatment group, a traditional Chinese medicine + metformin treatment group and a traditional Chinese medicine treatment group, and the age composition, the body weight index, the fasting blood glucose and the like of each group have no obvious difference. Each group of patients exercises in a proper amount, diet is strictly controlled, and 500mg is given before meals to the metformin treatment group; the traditional Chinese medicine + metformin treatment group is used for simultaneously administering 500ml of the traditional Chinese medicine composition every time 2 times a day on the basis of oral administration of metformin; the traditional Chinese medicine composition is 500ml per time and 2 times per day. 30 days is 1 course of treatment, and the curative effect is evaluated after 2 courses of treatment.

The results show that after 2 courses of treatment, fasting blood glucose and glycated hemoglobin of patients in the traditional Chinese medicine treatment group and the traditional Chinese medicine + metformin treatment group are both significantly reduced and reduced to normal adult levels, which proves that the traditional Chinese medicine composition can significantly reduce the blood glucose level of patients with type II diabetes, and the results are shown in table 3.

TABLE 3 Effect of Chinese medicinal composition on blood sugar and glycated hemoglobin of type II diabetic patients

P <0.05 for each group of pre-and post-treatment glycemia or glycated hemoglobin;

comparison of P <0.01 between pre-and post-treatment glucose or glycated hemoglobin

Test example 3: analysis of blood glucose level detection case after drug withdrawal

1. Yi in 53 years old, male, due to "dry mouth, emaciation", diagnosed type II diabetes. After taking metformin for 5 days, the patient feels abdominal distension, nausea and can not eat; after the gliclazide is taken for d days, the rash of the whole body is stopped. Checking fasting blood sugar 10.8mmol/L, 2 hours postprandial blood sugar 14.6mmol/L, and glycosylated hemoglobin 11.1%. Soaking with boiling water 1000ml per day, taking for 1 week, and then detecting the dry mouth, and repeatedly detecting fasting blood glucose 9.2 mmol/L. The administration is continued for 3 weeks, and then the fasting blood glucose is checked to be reduced to 6.8 mmol/L. The medicine is taken for 4 weeks continuously, and 5.4mmol/L of fasting blood sugar, 7.8mmol/L of blood sugar after 2 hours of meal and 5.6% of glycosylated hemoglobin are checked. The Chinese medicinal decoction is reduced to 500ml per day, and the blood sugar is basically stable after treatment for 4 weeks. The drug withdrawal follow-up period is 2 months, and the blood sugar and the glycosylated hemoglobin still maintain normal levels.

2. In 62 years old, Yang Shi, women, were diagnosed in our hospital for diabetes mellitus type II 5 years ago in hospitals in generous counties due to "dry mouth, polydipsia and emaciation". Once orally taken, diabetes pills, metformin and other medicaments are used for treatment, plain blood sugar is little, and the control condition is not detailed. The hospital checks that the fasting blood sugar is 12.6mmol/L, the blood sugar is 15.3mmol/L after 2 hours, and the glycosylated hemoglobin is 16.1 percent. After the treatment with the above medicines is stopped, the Chinese medicinal composition is infused with boiling water, 1000ml per day, and after 1 week of administration, the mouth feeling is improved, and the fasting blood glucose is rechecked to be 9.8 mmol/L. The administration is continued for 3 weeks, and then the fasting blood glucose is checked to be reduced to 7.3 mmol/L. After 4 weeks, the patients take the medicine continuously, and then the patients are rechecked for 5.6mmol/L of fasting blood sugar, 6.9mmol/L of blood sugar after 2 hours and 5.5% of glycosylated hemoglobin. The Chinese medicinal decoction is reduced to 500ml per day, and the blood sugar is basically stable after treatment for 4 weeks. The drug withdrawal follow-up period is 2 months, and the blood sugar and the glycosylated hemoglobin still maintain normal levels.

3. Liu Zhi, male, 57 years old, was diagnosed in our hospital for diabetes due to "dry mouth, polyuria", and 3 years ago, type II diabetes was diagnosed in Guiyang city people's hospital. The blood sugar is maintained at about 6.0mmol/L by taking the metformin and other medicaments orally. The fasting blood sugar of the hospital is 8.1mmol/L, the blood sugar of 2 hours after meal is 14.3mmol/L, and the glycosylated hemoglobin is 8.1 percent. After the metformin therapy is stopped, the Chinese medicinal composition is infused with boiling water, 1000ml is taken every day, after 1 week of taking the composition, the user feels dry mouth and polyuria is obviously improved, and after the user finishes the detection, the fasting blood sugar is 7.8 mmol/L. The administration is continued for 3 weeks, and then the fasting blood glucose is checked to be reduced to 7.3 mmol/L. After 4 weeks, the patients take the medicine continuously, and then the patients are rechecked for 5.8mmol/L of fasting blood sugar, 6.8mmol/L of blood sugar after 2 hours and 5.1% of glycosylated hemoglobin. The Chinese medicinal decoction is reduced to 500ml per day, and the blood sugar is basically stable after treatment for 4 weeks. The drug withdrawal follow-up period is 2 months, and the blood sugar and the glycosylated hemoglobin still maintain normal levels.

4. In Yang Jie, male age 48, the primary diagnosis is peripheral facial paralysis due to the "facial distortion, inability to close the eyes and bulge the mouth" of the patient. After admission, 28.1mmol/L of fasting blood sugar, 15.3mmol/L of blood sugar after 2 hours of meal and 11.1% of glycosylated hemoglobin are checked. The diagnosis is as follows: 1. peripheral facial paralysis; 2. type II diabetes. Taking metformin 500mg 2 times/d each time, and administering the Chinese medicinal composition for brewing with boiled water, 1000ml each day, and after taking for 1 week, completing fasting blood glucose 6.8 mmol/L. The administration is continued for 3 weeks, and then the fasting blood glucose is checked to be reduced to 5.8 mmol/L. After 4 weeks, the patients take the medicine continuously, and then the patients are rechecked for 5.1mmol/L of fasting blood sugar, 8.3mmol/L of blood sugar after 2 hours and 5.6% of glycosylated hemoglobin. The Chinese medicinal decoction is reduced to 500ml per day, and the blood sugar is basically stable after treatment for 4 weeks. The drug withdrawal follow-up period is 2 months, and the blood sugar and the glycosylated hemoglobin still maintain normal levels.

5. Yi in 47 years old, diabetes diagnosis 5 years, oral metformin, Damei kang sustained release tablet, and other drugs treatment, blood sugar control better. The fasting blood sugar of the hospital is 7.6mmol/L, the blood sugar of 2 hours after meal is 14.3mmol/L, and the glycosylated hemoglobin is 8.1 percent. Stopping the above-mentioned medicine treatment, soaking with boiling water, 1000ml per day, and after taking for 1 week, cleaning up fasting blood sugar 7.1 mmol/L. The administration is continued for 3 weeks, and then the fasting blood glucose is checked to be reduced to 6.3 mmol/L. After 4 weeks, the patients take the medicine continuously, and then the patients are rechecked for 5.8mmol/L of fasting blood sugar, 6.6mmol/L of blood sugar after 2 hours and 5.1% of glycosylated hemoglobin. The Chinese medicinal decoction is reduced to 500ml per day, and the blood sugar is basically stable after treatment for 4 weeks. The drug withdrawal follow-up period is 2 months, and the blood sugar and the glycosylated hemoglobin still maintain normal levels.

Research shows that the traditional Chinese medicine composition has the effects of reducing blood sugar and blood fat similar to metformin, and the blood sugar and the glycosylated hemoglobin can be maintained at normal levels in 3 months after a plurality of patients stop taking the composition.

The invention is not limited to the above alternative embodiments and various other forms of products can be made by anyone in the light of the present invention. The above detailed description should not be taken as limiting the scope of the invention, which is defined in the claims, and which the description is intended to be interpreted accordingly.

Claims

1. A traditional Chinese medicine composition for treating type II diabetes is characterized by comprising the following raw materials: affine cudweed, lily, spanishneedles herb, anemarrhena and astragalus;

2. The traditional Chinese medicine composition for treating type II diabetes mellitus according to claim 1, is characterized by comprising the following raw materials in parts by weight: 30-45 parts of affine cudweed, 10-15 parts of lily, 10-15 parts of spanishneedles herb, 5-10 parts of rhizoma anemarrhenae and 5-10 parts of astragalus membranaceus.

3. The traditional Chinese medicine composition for treating type II diabetes mellitus according to claim 2, is characterized by comprising the following raw materials in parts by weight: 40 parts of affine cudweed, 15 parts of lily, 15 parts of spanishneedles herb, 10 parts of rhizoma anemarrhenae and 10 parts of astragalus membranaceus.

4. A preparation method of a traditional Chinese medicine composition for treating type II diabetes is characterized by comprising the following steps:

5. The method for preparing a Chinese medicinal composition for treating type II diabetes as claimed in claim 4, wherein the lily is washed with water before soaking, soaked for 7-9 hours, dewatered after soaking to remove white foam, then added with 1000-2000 ml of water, and then the cleaned, cut and dried affine cudweed, sticktight, rhizoma anemarrhenae and radix astragali are added, decocted in two times, each time for 40-60 minutes, and the decocted liquid of the two times is collected.

6. The preparation method of the traditional Chinese medicine composition for treating type II diabetes mellitus as claimed in claim 5, wherein the traditional Chinese medicine composition comprises 40 parts of affine cudweed, 15 parts of lily, 15 parts of bidens bipinnata, 10 parts of rhizoma anemarrhenae and 10 parts of astragalus membranaceus.