CN104815131A

CN104815131A - Pharmaceutical composition for treating chicken gout and preparation method thereof

Info

Publication number: CN104815131A
Application number: CN201510269533.4A
Authority: CN
Inventors: 袁春梅
Original assignee: Individual
Current assignee: Individual
Priority date: 2015-05-25
Filing date: 2015-05-25
Publication date: 2015-08-05

Abstract

The invention discloses a pharmaceutical composition for treating chicken gout and a preparation method thereof. The pharmaceutical composition comprises the following raw medicinal materials: achyranthes aspera, begonia roots, China rose, lacca, lamiophlomis rotate, herba lycopi, madder, lycopodium obscurum, huechys, lantana camara, fringed iris herb, aizoon stonecrop herb, piper hancei, peruvian groundcherry herb, grub, homalocladium platycladum, cinnamon, semen brassicae, Indian kalimeris herb, Chinese tupistra rhizome, camphortree, zanthoxylum planispinum, osmorhiza aristata, panax pseudo-ginseng Wsll. Var, girald jasmine root, radix glehniae, roundleaf dutchmanspipe root, baeckea frutescens, zornia diphylla pers, cyrtomium fortunei, amur lilac, celandine and blumea. The pharmaceutical composition disclosed by the invention has the beneficial effects of promoting blood circulation and removing stasis, relieving swelling and stopping pain, dredging channels and dispelling cold, warming blood and promoting granulation, and diminishing inflammation and reducing internal heat; syndrome differentiation and treatment are carried out on the basis of holistic view, the targeting property is high, the efficacy is capable of directly achieving lesions to effectively control the condition, and the curative effect is remarkable; moreover, by using the pure natural traditional Chinese medicinal materials, the pharmaceutical composition is cheap, safe and effective, free from medicine residue, and capable of improving the appetite of chicken and meeting the nutritional needs thereof.

Description

A kind of pharmaceutical composition being used for the treatment of chicken gout and preparation method thereof

Technical field

The present invention relates to herbal medicine technical field, particularly a kind of pharmaceutical composition being used for the treatment of chicken gout and preparation method thereof.

Background technology

Gout refers in fowl blood that accumulating excessive urate (urate) can not be excreted rapidly, form hyperuricemia (hyperuricaemia), and then urate deposition is in joint capsule, articular cartilage, periarticular, breast, abdominal cavity and various organ surface and other stromas.Clinical signs is bradykinesia, the swelling of lower limb conjunctura, anorexia, exhaustion and diarrhoea.Because in fecaluria, urate increases, normal on perianal feather is that the urate of volume white attaches.Chicken gout occupies sizable ratio in some chicken groups, and gross (1940) postmortem 8603 chickens, nephritis and gout account for (1975) such as 15%, brigden and add up some chicken house disease incident, and gout accounts for 16% ~ 50%.Primary disease has and increases trend, the particularly chicken group of intensive farm in recent years, Feed Manufacturing, feeding and management level preset many factors of bringing out fowl gout, become one of common fowl diseases at present.

The cause of disease: the reason of fowl gout can be caused to have kind more than 20, be summed up and can be divided into two classes.One is that in body, uricopoiesis is too many, and two is uric acid excretion disorders.The latter may be prior reason in uratohistechia.Cause uricopoiesis too much because have: in feedstuff protein especially nucleoprotein and purine base content too many.If the thymus with animal, liver, kidney, brain, film gland, head meat, meat bits, fish flour, Semen sojae atricolor powder, Semen Pisi sativi etc. are as protein source, and the ratio accounted for is too high.If fish flour consumption is more than 8%, or urea content reaches more than 13% feeding animals, in feedstuff, (Wang Yuebang, during 1991 > more than 28% for crude protein content, due to the metabolic end product of nucleic acid and purine, uricopoiesis is too many one by one, causes hyperuricemia.When animal ravenous hunger is again less than energy supplement, body protein decomposes in a large number.As lymphocytic leukosis, during the severe such as monocytosis, blue comb wasting diseases, because body protein decomposes rapidly, in a large number, in body, urate generates and increases.Someone finds in recent years, even if protein content is up to 60% (silk, 1981) in feedstuff, even reach 80% (peterson, 1971), the chicken fed gout does not occur.Some kind chicken gout incidence rate is very high.Thus think relevant with inherited genetic factors.Particularly joint type gout and high protein feed and inherited genetic factors in close relations.Even oneself have selected the chicken of heritability hyperuricemia system to some scholar.High protein feed has facilitation to this kind of chicken gout.Limit protein matter supplies, and can delay or prevent this chicken from suffering from joint type gout.

Cause the factor of uric acid excretion disorder can be divided into infectious agent and the large class of non-pathogenic factors two.Be infectious bronchitis virus (infectious bronchitis virus, ibv) in infectious agent, and wherein some bacterial strain has strong addicted to kidney, can cause nephritis, injury of kidney causes urate to drain and be obstructed, occur typical gout.All tools addicted to kidney ' property, the pathogenic microorganism of kidney legion can be caused, as infectious bursal disease virus, septic Mycoplasma, young Hakuri, eimeria tenella, infectiousness Ceco-hepatitis virus all can cause gout.Trophism and toxic factor two class is comprised in non-infectious factor.Cause renal tubules, ureter epithelium dysbolismus as va lacks, urate excretion is obstructed.Sal is too much, subimbition, and hypourocrinia, urine are concentrated; Calcic is too many, phosphorous deficiency, or calcium, phosphorus ratio imbalance cause calcium dystopy calm, form renal calculus or long-pending sand, make to urinate not smooth.In toxic factor as addicted to kidney chemical toxicant, medicine and mycotoxin, in feedstuff, some heavy metal causes injury of kidney as chromium, sodium, thallium, hydrargyrum, lead etc. are accumulated in kidney; The too much feedstuff of oxalate content such as the feedstuff Oxalates such as Herba Spinaciae, Caulis et Folium Lactucae sativae, Caulis et Folium Brassicae capitatae of blooming, mushroom and careless class can block renal tubules or damage renal tubules; Mycotoxin is as brown aspertoxin (ochratoxins), fusarium toxin (fusariumtoxin) and aflatoxin (aflatoxin), follicle mycin (oosporein) etc., can coup injury kidney, cause kidney malfunction and cause gout.When urate generates too much, when excretion is obstructed, blood uric acid salinity raises, and can irritate and induced renal damage when renal excretion, urate retardance occurs, impels again blood uric acid salt to raise further conversely, cause vicious cycle.

Pathogeny: think that primary renal damage is the basis that gout occurs in recent years, gout is fowl renal failure (poultry renal failure).For want of arginase in poultry body, the ammonia produced in metabolic process can not be synthesized as carbamide, but first purine biosynthesis, hypoxanthine, xanthine, then form uric acid and allantoin, finally drained through kidney.Uric acid is difficult to water-soluble, is very easily combined with sodium or calcium and forms Monosodium urate and calcium urate.And it is easily calm in renal tubules, articular cavity or visceral surface.Especially nucleoprotein is more containing protein for feedstuff, and the ammonia formed in body is more.As long as the xanthine oxidase that body includes molybdenum is sufficient, the uric acid of generation is also more.If urate formation speed is greater than the discharge capacity of urinary organs, just lithemia can be caused.When kidney, ureter etc. be inflamed, block time, urate excretion is obstructed, urate just accumulation in blood and and then calmness at organ surfaces such as pleural space, peritoneal cavity, liver, kidney, board, mesentery, intestinal.Therefore, all cause kidney and injury of urinary tract or urine is concentrated, the factor of homaluria obstacle, all can promote lithemic generation.The biogenic materials such as avian infectious bronchitis virus, bursa fabricic virus (ibv), can coup injury nephridial tissue, causes nephrocyte disintegrate; Mycotoxin, heavy metal ion also can damage renal tubules and glomerule directly or indirectly, cause kidney parenchymatous degeneration.Va lacks, and causes renal tubules, the metabolism disorder of ureter epithelial cell and keratinization raw, mucous secretion is reduced, and urate excretion is obstructed.High calcium or the low-phosphorous urine ph value that makes raise, and blood buffer ability declines.High calcium and alkaline environment, be conducive to the deposition of health acid calcium, cause urinary calculus, blocking renal tubules.Time the while that Sal being too much, subimbition, urine are concentrated with kidney itself or urinary tract inflammation, urate all can being made to drain and to be obstructed, promote that it is calm in vivo, promote gout generation.But and not all injury of kidney can cause gout to generate, as glomerulonephritis, interstitial nephritis etc. seldom occur together gout.The number that this and urate are formed, the degree etc. that urinary tract is unobstructed have substantial connection.

Clinical manifestation: the gout sickness rate of two types, clinical manifestation have larger difference.Be main mainly with visceroatonia type gout in production, joint type gout is more rare.

Visceroatonia type gout: sporadicly or in batch occur, how dead because of renal failure.Uncomfortable when sick fowl starts, digestion is upset and diarrhoea.In 6 ~ 9 days, in chicken group, symptom represents completely, mostly is chronic process, as appetite decline, cockscomb whiting, anemia, molt, poor growth, feces are white rare water sample, most chicken non-evident sympton, or sudden death.Because pathogenesis is different, primary symptom is also different.By infectious bronchitis virus causer, have the symptoms such as accelerated breathing, cough, sneeze, va lacks caused person, and with symptoms such as xerophthalmia, nostril easily block, Gao Meng, low-phosphorous causer, also can occur dysostosis.

Joint type gout: the soft swelling of lower limb, conjunctura, particularly the attached joint of toe, conjunctura swelling, pain, bradykinesia limb capable, can not stand, cutting articular cavity has the white sticky liquid of stiff to flow out, and spinal column sometimes, even also can form nodositas swelling in wattle skin.

Visceroatonia type gout cuts open inspection change: visceral serosal such as the organ surfaces such as pericardium, pleura, peritoneum, liver, spleen, stomach cover the uratic deposit thing of one deck white, Calx sample, renomegaly, and color is pale, and surface, in snowflake sample decorative pattern, also shows in excess of the kidney matter.Ureter increases thick, inside has urate crystal, is thus also called fowl urinary calculus (urolithiasis).Shane (feed to pullet in 8 ~ 20 week age, and can cause arthritis interna and calcium urate calmness, parathyroid gland weight saving, function reduction, chicken death rate increases by the 1969 > daily ration of the calcium containing 2.5%.Other changes are become thin, are dewatered, dysplasia.

Joint type gout cuts open inspection change: cutting diseased joints intracavity has creamy white thick liquid to flow out, periarticular soft tissues is so that in whole leg muscle tissue, all white uratosis be can see, because urate crystal is irritant, articular surface ulcer and joint capsule necrosis often can be caused.

Histological change: visceroatonia type gout Main change is at kidney.Nephridial tissue endogenous cause of ill uratosis, nephritis-nephrotic syndrome that to be formed with tophus (tophus) be feature.Tophus is a kind of special granuloma, by to disperse or agglomerating urate crystal is deposited in slough, around assemble inflammatory cell, phagocyte, giant cell, fibroblast etc., the nephropathy symptom such as have renal cells swelling, degeneration, necrosis, come off.Lumen distention, forms cast by cell debris and urate crystal.Glomerule change is generally not obvious.Renal tubules tube chamber blocks, and blister cavities can be caused to be formed, interstitial fibrosis.Lack causer by ibv addicted to kidney strain infection, va, be also shown in the phenomenon such as lymphocytic infiltration, the life of upper cornification.Joint type gout has urate crystal being injured in articular cavity, synovial membrane surface acute inflammation, and in surrounding tissue, tophus is formed, and is even diffused in muscle and also has tophus, sometimes have around it giant cell around.

Clinical pathological change: uric acid in blood salinity raises, and is elevated to 0.897mmol/l(15mg% from 0.09 ~ 0.18mmol/l time normal (1.5 ~ 3.0mg%)) more than., when ibv infects addicted to kidney strain, also there is water and the electrolytical negative balance such as the reduction of na+, k+ concentration, dehydration in non-protein nitrogen (npn) value also corresponding rising in blood.Blood ph value reduces, and because of body dehydration, red cell volume (pcv) value raises, and sedimentation rate slows down, and urine calcium concentration raises, and urine ph value also raises.

Diagnosis: before death according to limping, attached joint, the soft swelling of shoulder joint, feces color is white and rare, can make tentative diagnosis.Make a definite diagnosis and depend on blood uric acid and the rising of urate concentration, visceral surface has uratosis, and arthral fluid is the change of the characteristic such as white opacity and tophus generation.But should distinguish with the microbial infectiousness synovitis of joint type tuberculosis, Salmonella and bead.Check in joint fluid and whether have needle-like and sheaf shape crystal or radiation crystal grain can make difference diagnosis.

Treatment: control gross protein value in chicken feedstuff and, about 20%, reduce the supply of animality leftover bits and pieces, forbid feeding with animal glands tissue, supply containing the abundant feedstuff of va, significant in prevention primary disease.In Breeding of Broiler Chicks, feed with the feedstuff of the rich in proteins such as pluck, meat bits, fish flour, should suitably coordinate according to chicken age in days, body weight or be interrupted supply.Plant in chicken feedstuff and mix sardine, dry cattle manure (including vb12) is fed, can prevent gout from occurring.Cage bird increases motion can reduce gout sickness rate.Calcium, available phosphorus content and calcium thereof, phosphorus ratio in the feedstuff supplied in each physiological stage of strict control poultry, in broiler chicken feed, calcic should not more than 1%, and in pullet feedstuff, calcic is no more than 1.2%, and phosphorus is no more than 0.8%, is suitable.

Few to the true fruitful method of primary disease treatment.Except precious birds, therapeutic potential is little.Can extract the tophus in articular cavity, but effect is unsatisfied with, also useful allopurinol treatment, because xanthine oxidase competed by it and xanthine, reduces uricopoiesis.But this method is paid wages very large on the one hand economically, in body, the ammonia of synthesis, because not being converted into uric acid, can cause new adverse consequences on the other hand.Key should be set about from prevention, and improve chicken group feed supply, feeding and management is only active measures.

But Chinese medicine prevention chicken gout disease have accumulated abundant clinical experience, has abundant theoretical basis, utilizes Traditional Chinese medical theory, determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs is carried out on the basis of Overall View, have good advantage.

Summary of the invention

Technical problem to be solved by this invention is to provide a kind ofly treats pharmaceutical composition of chicken gout disease and preparation method thereof, has blood circulation promoting and blood stasis dispelling, effect that reducing swelling and alleviating pain, cold expelling of promoting blood circulation, warm blood granulation promoting, antiinflammatory are reduced internal heat.Utilize Traditional Chinese medical theory, determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs is carried out on the basis of Overall View, targeting is comparatively strong, and drug effect can be gone directly focus, and effective symptom management is evident in efficacy, can reduce ill mortality rate, improve and cure survival rate etc.Further, adopt natural Chinese medicines material, cheap, safe and effective, drug residue free, while control chicken gout, can improve the appetite of chicken, meet its growing nutrient demand.

In order to solve the problems of the technologies described above, the invention provides a kind of pharmaceutical composition being used for the treatment of chicken gout disease, wherein, described pharmaceutical composition comprises following raw medicinal material: Radix Achyranthis, Radix Bischofiae Javanicae, Flos Rosae Chinensis, Lacca, Radix Lamiophlomidis Rotatae, Herba Lycopi, Radix Rubiae, Herba Lycopodii Obscuri, Huechys sanguinea De Geer., Folium Lantanae Camarae, Herba Iridis japonicae, Herba Sedi Aizoon, Cauliset Folium Piperis Hancei, Fructus Seu Herba Pubescentis, Holotrichia diomphalia Bates, Herba Homalocladii Platycladii, Cortex Cinnamomi, Semen Sinapis Albae, Herba Kalimeridis, Rhizoma Tupistrae pachynemae, Lignum cinnamomi camphorae, Fructus Zanthoxyli Plansipini, Radix Osmorhizae Laxae, Rhizoma panacis majoris, Radix Jasmini Giraldii, Radix Glehniae, Fructus Aristolochiae Kwangsiensis, Folium Baeckeae, Herba Zornia Diphyllae, Rhizoma Osmundae, Cortex Syringae, Herba Chelidonii, Herba Blumeae Lacerae.

Wherein, in described pharmaceutical composition, the parts by weight of each raw medicinal material are: Radix Achyranthis 20-30 weight portion, Radix Bischofiae Javanicae 15-20 weight portion, Flos Rosae Chinensis 20-25 weight portion, Lacca 1-3 weight portion, Radix Lamiophlomidis Rotatae 2-4 weight portion, Herba Lycopi 10-15 weight portion, Radix Rubiae 10-20 weight portion, Herba Lycopodii Obscuri 15-20 weight portion, Huechys sanguinea De Geer. 2-4 weight portion, Folium Lantanae Camarae 1-4 weight portion, Herba Iridis japonicae 2-5 weight portion, Herba Sedi Aizoon 10-20 weight portion, Cauliset Folium Piperis Hancei 15-25 weight portion, Fructus Seu Herba Pubescentis 7-13 weight portion, Holotrichia diomphalia Bates 1-3 weight portion, Herba Homalocladii Platycladii 20-25 weight portion, Cortex Cinnamomi 10-20 weight portion, Semen Sinapis Albae 2-4 weight portion, Herba Kalimeridis 10-20 weight portion, Rhizoma Tupistrae pachynemae 2-4 weight portion, the sub-15-25 weight portion of Lignum cinnamomi camphorae, Fructus Zanthoxyli Plansipini 3-5 weight portion, Radix Osmorhizae Laxae 15-25 weight portion, Rhizoma panacis majoris 6-13 weight portion, Radix Jasmini Giraldii 10-20 weight portion, Radix Glehniae 15-20 weight portion, Fructus Aristolochiae Kwangsiensis 8-15 weight portion, Folium Baeckeae 15-20 weight portion, Herba Zornia Diphyllae 12-22 weight portion, Rhizoma Osmundae 2-4 weight portion, Cortex Syringae 10-20 weight portion, Herba Chelidonii 2-4 weight portion, Herba Blumeae Lacerae 15-20 weight portion.

Wherein, in described pharmaceutical composition, the parts by weight of each raw medicinal material are: Radix Achyranthis 25-30 weight portion, Radix Bischofiae Javanicae 15-20 weight portion, Flos Rosae Chinensis 20-25 weight portion, Lacca 1-3 weight portion, Radix Lamiophlomidis Rotatae 2-4 weight portion, Herba Lycopi 10-15 weight portion, Radix Rubiae 15-20 weight portion, Herba Lycopodii Obscuri 15-20 weight portion, Huechys sanguinea De Geer. 2-4 weight portion, Folium Lantanae Camarae 1-4 weight portion, Herba Iridis japonicae 2-5 weight portion, Herba Sedi Aizoon 15-20 weight portion, Cauliset Folium Piperis Hancei 15-20 weight portion, Fructus Seu Herba Pubescentis 7-13 weight portion, Holotrichia diomphalia Bates 1-3 weight portion, Herba Homalocladii Platycladii 20-25 weight portion, Cortex Cinnamomi 10-15 weight portion, Semen Sinapis Albae 2-4 weight portion, Herba Kalimeridis 15-20 weight portion, Rhizoma Tupistrae pachynemae 2-4 weight portion, the sub-15-20 weight portion of Lignum cinnamomi camphorae, Fructus Zanthoxyli Plansipini 3-5 weight portion, Radix Osmorhizae Laxae 15-20 weight portion, Rhizoma panacis majoris 6-13 weight portion, Radix Jasmini Giraldii 15-20 weight portion, Radix Glehniae 15-20 weight portion, Fructus Aristolochiae Kwangsiensis 8-15 weight portion, Folium Baeckeae 15-20 weight portion, Herba Zornia Diphyllae 12-22 weight portion, Rhizoma Osmundae 2-4 weight portion, Cortex Syringae 15-20 weight portion, Herba Chelidonii 2-4 weight portion, Herba Blumeae Lacerae 15-20 weight portion.

Wherein, in described pharmaceutical composition, the parts by weight of each raw medicinal material are: Radix Achyranthis 25 weight portion, Radix Bischofiae Javanicae 17 weight portion, Flos Rosae Chinensis 23 weight portion, Lacca 2 weight portion, Radix Lamiophlomidis Rotatae 3 weight portion, Herba Lycopi 13 weight portion, Radix Rubiae 15 weight portion, Herba Lycopodii Obscuri 17 weight portion, Huechys sanguinea De Geer. 3 weight portion, Folium Lantanae Camarae 3 weight portion, Herba Iridis japonicae 4 weight portion, Herba Sedi Aizoon 16 weight portion, Cauliset Folium Piperis Hancei 18 weight portion, Fructus Seu Herba Pubescentis 8 weight portion, Holotrichia diomphalia Bates 2 weight portion, Herba Homalocladii Platycladii 22 weight portion, Cortex Cinnamomi 16 weight portion, Semen Sinapis Albae 3 weight portion, Herba Kalimeridis 16 weight portion, Rhizoma Tupistrae pachynemae 3 weight portion, Lignum cinnamomi camphorae 17 weight portions, Fructus Zanthoxyli Plansipini 4 weight portion, Radix Osmorhizae Laxae 17 weight portion, Rhizoma panacis majoris 8 weight portion, Radix Jasmini Giraldii 15 weight portion, Radix Glehniae 17 weight portion, Fructus Aristolochiae Kwangsiensis 8 weight portion, Folium Baeckeae 18 weight portion, Herba Zornia Diphyllae 18 weight portion, Rhizoma Osmundae 3 weight portion, Cortex Syringae 16 weight portion, Herba Chelidonii 3 weight portion, Herba Blumeae Lacerae 16 weight portion.

Wherein, in described pharmaceutical composition, the parts by weight of each raw medicinal material are: Radix Achyranthis 30 weight portion, Radix Bischofiae Javanicae 16 weight portion, Flos Rosae Chinensis 22 weight portion, Lacca 2 weight portion, Radix Lamiophlomidis Rotatae 3 weight portion, Herba Lycopi 14 weight portion, Radix Rubiae 16 weight portion, Herba Lycopodii Obscuri 17 weight portion, Huechys sanguinea De Geer. 3 weight portion, Folium Lantanae Camarae 2 weight portion, Herba Iridis japonicae 3 weight portion, Herba Sedi Aizoon 16 weight portion, Cauliset Folium Piperis Hancei 17 weight portion, Fructus Seu Herba Pubescentis 8 weight portion, Holotrichia diomphalia Bates 2 weight portion, Herba Homalocladii Platycladii 22 weight portion, Cortex Cinnamomi 13 weight portion, Semen Sinapis Albae 3 weight portion, Herba Kalimeridis 16 weight portion, Rhizoma Tupistrae pachynemae 3 weight portion, Lignum cinnamomi camphorae 16 weight portions, Fructus Zanthoxyli Plansipini 4 weight portion, Radix Osmorhizae Laxae 16 weight portion, Rhizoma panacis majoris 8 weight portion, Radix Jasmini Giraldii 16 weight portion, Radix Glehniae 16 weight portion, Fructus Aristolochiae Kwangsiensis 9 weight portion, Folium Baeckeae 18 weight portion, Herba Zornia Diphyllae 18 weight portion, Rhizoma Osmundae 3 weight portion, Cortex Syringae 16 weight portion, Herba Chelidonii 3 weight portion, Herba Blumeae Lacerae 17 weight portion.

In order to solve the problems of the technologies described above, present invention also offers a kind of described pharmaceutical composition being used for the treatment of chicken gout, wherein, the dosage form of described pharmaceutical composition is tablet, and its preparation method comprises the following steps:

The first step, is mixed in proportion described raw medicinal material, and adding relative to the determining alcohol of mixture quality 1 ~ 3 times is the ethanol of 80 ~ 90%, reflux 2 ~ 4 hours, extracts, and filters acquisition first extracting solution; It is the ethanol of 80 ~ 90% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 1 ~ 2 times again, reflux 1 ~ 3 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;

Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 1 ~ 2 hour, pulverize, sieve, obtain 200 order ~ 400 object micropowders;

3rd step, by the micropowders that second step obtains, add relative to the microcrystalline Cellulose of its quality 0.01 ~ 0.2 times, 0.01 ~ 0.2 times of lactose, the starch of 0.01 ~ 0.2 times, sieve, mix homogeneously, granulate, drying, adds relative to micropowders quality 0.001 ~ 0.02 times of magnesium stearate, granulate, tabletting, makes.

Wherein, the dosage form of described pharmaceutical composition is granule, and its preparation method comprises the following steps:

Step one: described raw medicinal material is mixed in described ratio, adding relative to the determining alcohol of 3 ~ 5 times, mixture is the ethanol of 80% ~ 90%, be heated to boiling reflux 4 ~ 6 hours, filter, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, when being evaporated to 40 ~ 60 DEG C subsequently under vacuum 0.04 ~ 0.06Mpa, relative density is the mastic of 1.14 ~ 1.16, spraying dry, the inlet temperature 160 ~ 175 DEG C of spray dryer, leaving air temp 80 ~ 85 DEG C, be ground into powder subsequently, make dried cream powder;

Step 2: the dextrin adding cane sugar powder relative to dried cream powder quality 0.1 ~ 0.3 times and 0.1 ~ 0.2 times in the dried cream powder obtained, makes granule, in 45 ~ 50 DEG C of dryings, obtains granule.

Wherein, the dosage form of described pharmaceutical composition is injection, and its preparation method comprises the following steps:

The first step, described raw medicinal material is mixed in proportion, put into super micron mill and be ground into the mixed powder that the micron particles of 0.1 ~ 10 μm of volume average particle size and particle diameter be less than the nano-scale particle composition of 0.1 μm of volume average particle size, described mixed powder powder rate be at least 97%;

Second step, adding relative to the determining alcohol of the quality 3 ~ 5 times of described mixed powder in the mixed powder that the first step obtains is the ethanol of 80% ~ 90%, stirring and dissolving obtains alcoholic solution, alcoholic solution is left standstill 24 ~ 36 hours under the condition of 5 DEG C ~ 15 DEG C, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, concentrated and dry, and put into super micron mill pulverizing 45 ~ 60 minutes at this, the micron particles of acquisition 0.1 ~ 10 μm of volume average particle size and particle diameter are less than the mixed powder of the nano-scale particle composition of 0.1 μm of volume average particle size, the powder rate that obtains of described mixed powder is at least 97%,

3rd step, gets mixed powder 5g ~ 10g that second step obtains, adds propylene glycol 10g ~ 30g, add 200ml water for injection, stirs and makes it dissolve, inject water to 1000ml further, then add 1g ~ 1.2g needle-use activated carbon, fully stir 30 ~ 50 minutes; Decarbonization filtering; With 0.22 ~ 0.24 μm of filtering with microporous membrane; Lyophilization obtains sterilized powder, and subpackage embedding, to obtain final product.

Wherein, the dosage form of described pharmaceutical composition is powder, and its preparation method comprises the following steps:

The first step, is mixed in proportion described raw medicinal material, is ground into powder;

Second step, the first step is obtained powder and add in cold water and soak 3 hours ~ 10 hours, with slow fire boiling, decocting time is 3 ~ 5 hours, decoction liquor is filtered, obtains the first filtrate, and the quality of the water added is 2 ~ 4 times of the powder quality that the first step obtains;

3rd step, filters second step the filtering residue obtained and again adds in cold water, with slow fire boiling 2 ~ 4 hours, filters acquisition second filtrate, and the quality of the water added is 2 ~ 4 times of the powder quality that second step obtains;

4th step, the second filtrate mixing that the first filtrate obtain second step and the 3rd step obtain, concentrating under reduced pressure, except anhydrating, dry, pulverize powdered, and granularity is 100 ~ 150 orders;

5th step, in the powder that described 4th step obtains, add starch, the percentage by weight of described starch in described powder is 10% ~ 15%, by the material pouch after mixing or packing box subpackage.

The invention has the beneficial effects as follows: effect that the present invention has blood circulation promoting and blood stasis dispelling, reducing swelling and alleviating pain, cold expelling of promoting blood circulation, warm blood granulation promoting, antiinflammatory are reduced internal heat.Utilize Traditional Chinese medical theory, determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs is carried out on the basis of Overall View, targeting is comparatively strong, and drug effect can be gone directly focus, and effective symptom management is evident in efficacy, can reduce ill mortality rate, improve and cure survival rate etc.Further, adopt natural Chinese medicines material, cheap, safe and effective, drug residue free, while control chicken gout, can improve the appetite of chicken, meet its growing nutrient demand.

Detailed description of the invention

This pharmaceutical composition, there is blood circulation promoting and blood stasis dispelling, effect that reducing swelling and alleviating pain, cold expelling of promoting blood circulation, warm blood granulation promoting, antiinflammatory are reduced internal heat, its prescription is: Radix Achyranthis, Radix Bischofiae Javanicae, Flos Rosae Chinensis, Lacca, Radix Lamiophlomidis Rotatae, Herba Lycopi, Radix Rubiae, Herba Lycopodii Obscuri, Huechys sanguinea De Geer., Folium Lantanae Camarae, Herba Iridis japonicae, Herba Sedi Aizoon, Cauliset Folium Piperis Hancei, Fructus Seu Herba Pubescentis, Holotrichia diomphalia Bates, Herba Homalocladii Platycladii, Cortex Cinnamomi, Semen Sinapis Albae, Herba Kalimeridis, Rhizoma Tupistrae pachynemae, Lignum cinnamomi camphorae, Fructus Zanthoxyli Plansipini, Radix Osmorhizae Laxae, Rhizoma panacis majoris, Radix Jasmini Giraldii, Radix Glehniae, Fructus Aristolochiae Kwangsiensis, Folium Baeckeae, Herba Zornia Diphyllae, Rhizoma Osmundae, Cortex Syringae, Herba Chelidonii, Herba Blumeae Lacerae.

Wherein, Radix Achyranthis, Radix Bischofiae Javanicae, Flos Rosae Chinensis, Lacca, Radix Lamiophlomidis Rotatae, Herba Lycopi, Radix Rubiae, Herba Lycopodii Obscuri, Huechys sanguinea De Geer. blood circulation promoting and blood stasis dispelling; Folium Lantanae Camarae, Herba Iridis japonicae, Herba Sedi Aizoon, Cauliset Folium Piperis Hancei, Fructus Seu Herba Pubescentis, Holotrichia diomphalia Bates, Herba Homalocladii Platycladii reducing swelling and alleviating pain; Cortex Cinnamomi, Semen Sinapis Albae, Herba Kalimeridis, Rhizoma Tupistrae pachynemae, Lignum cinnamomi camphorae, Fructus Zanthoxyli Plansipini, Radix Osmorhizae Laxae are promoted blood circulation cold expelling; Rhizoma panacis majoris, Radix Jasmini Giraldii, Radix Glehniae, Fructus Aristolochiae Kwangsiensis, Folium Baeckeae, Herba Zornia Diphyllae warm up blood granulation promoting; Rhizoma Osmundae, Cortex Syringae, Herba Chelidonii, Herba Blumeae Lacerae antiinflammatory are reduced internal heat.

The pharmacology of various raw medicinal material is as follows:

Radix Achyranthis: [nature and flavor] micro-hardship is cool.[function cures mainly] heat clearing away, removing toxic substances, diuresis.For cold, fever, tonsillitis, diphtheria, mumps, malaria, rheumatic arthritis, urinary system calculus, oedema due to nephritis.

Radix Bischofiae Javanicae: [source] is the root of Flos Begoniae Evansianae kind of plant Flos Begoniae Evansianae.[nature and flavor] are " Guizhou medical herbs " 1.: " property is put down, sour-puckery flavor.The acid of " 2. " Shaanxi Chinese herbal medicine ": " bitter and puckery flavor, cold in nature." [function cures mainly] blood circulation promoting and blood stasis dispelling, hemostasis, heat clearing away.Control traumatic injury, spit blood, spit blood, dysentery, menoxenia, metrorrhagia, leukorrhagia, stranguria with turbid discharge, laryngalgia.1. " classify herbal ": " control haematemesis, traumatic injury." 2. " Guizhou side among the people medicine collection ": " emesis blood, spitting of blood, knife injury are hemorrhage." 3. " Guizhou medical herbs ": " blood circulation promoting and blood stasis dispelling, cooling blood for hemostasis." 4. " Shaanxi Chinese herbal medicine ": " promoting blood circulation to remove blood stasis, heat clearing away, hemostasis and pain-relieving.Control traumatic injury, spit blood, epistaxis, gastric ulcer, dysentery, lung abscess, metrorrhagia, leucorrhea, menoxenia." 5. Jiangxi " medical herbs handbook ": " circulation of qi promoting promoting the circulation of blood, reducing swelling and alleviating pain, spasmolytic, controls scrofula."

Flos Rosae Chinensis: [nature and flavor] are sweet, temperature.[return through] returns Liver Channel.[function cures mainly] promoting blood flow to regulate menstruation, loose poison detumescence.Flower: for menoxenia, dysmenorrhea, carbuncle furuncle and phyma poison, tuberculous lymphadenitis (non-diabrosis).Leaf: tuberculous lymphadenitis, traumatic injury.Root: traumatic injury, leucorrhea, seminal emission.

Lacca: [nature and flavor] are bitter, cold.1. Tang Materia Medica: " sweet-salty is flat." 2. " Japan hanako materia medica ": " is nontoxic." 3. " Chinese medicinal herbal ": " is bitter, cold." [function cures mainly] heat clearing away, removing heat from blood, removing toxic substances.Control measles, macule is not easily sent out thoroughly, puerperal blood faints, leukorrhagia, skin ulcer scabies toxic swelling.1. Tang Materia Medica: " main the five internal organs pathogen, leukorrhagia, pained, removing mass blood, incised wound raw meat." 2. " Haiyao Bencao, Oversea Materia Medica ": " controls pruritus due to damp pathogen skin ulcer scabies, should enter cream and use.It is not saturating that " 3. " Chinese medicinal herbal ": " controls macule, and measles does not go out."

Radix Lamiophlomidis Rotatae: [nature and flavor] are bitter, are slightly cold.1. " Traditional Chinese Medicine in Sichuan will ": " bitter, be slightly cold." 2. " Qinghai-Tibet medicine illustrated handbook ": " is bitter, temperature." [function cures mainly] invigorates blood circulation, clots absorbing, detumescence, hemostasis.Control and get injured by a fall muscles and bones, sprain one's back and frustrate gas, yellow fluid is amassed in joint.1. " Traditional Chinese Medicine in Sichuan will ": " blood circulation promoting competent silt, pain relieving, circulation of qi promoting, detumescence, reunion of fractured tendons and bones.Control and get injured by a fall muscles and bones and diseases such as frustrating gas of spraining one's back." 2. " Qinghai-Tibet medicine illustrated handbook ": " mends marrow, hemostasis.Flow yellow fluid after controlling edema, yellow fluid is amassed in joint, spongy bone inflammation."

Herba Lycopi: [nature and flavor] are bitter, pungent, tepor.[return through] returns liver, spleen channel.[function cures mainly] blood circulation promoting and blood stasis dispelling, line water detumescence.For menoxenia, amenorrhea, dysmenorrhea, postnatal blood stasis is suffered from abdominal pain, edema.

Radix Rubiae: [nature and flavor] are bitter, cold.[return through] returns Liver Channel.[function cures mainly] removing heat from blood, hemostasis, blood stasis dispelling, stimulates the menstrual flow.For spitting blood, epistaxis, metrorrhagia, traumatic hemorrhage, amenorrhea stasis blocking, arthralgia, tumbling and swelling.

Herba Lycopodii Obscuri: [habitats distribution] is born in sylvan life hillside.China's most area has distribution.Not [nature and flavor] " not Lu ": " acid, temperature, nontoxic." [function cures mainly] 1. " not Lu ": " QI invigorating, quenches the thirst." 2. supplement to the Herbal: " gets rhizome infusing drugs in wine, removes wind blood, except wind scabies, and should be old."

Huechys sanguinea De Geer.: [nature and flavor] are bitter is flat.Poisonous.[function cures mainly] blood circulation promoting and blood stasis dispelling, detoxicating and resolving stagnation of pathogens.For blood stasis amenorrhea, tuberculous lymphadenitis, lyssodexis; Scabies skin infection is controlled in external.

Folium Lantanae Camarae: [nature and flavor] root: light, cool.Branch, leaf: bitter, cool, tool foul smell.[function cures mainly] root: heat-clearing and toxic substances removing, removing obstruction for relieving pain.For cold and high fever, heat of a specified duration is not moved back, the tuberculosis of cervical lymph nodes, rheumatic ostalgia, stomachache, traumatic injury.Leaf, branch: eczema is controlled in external, dermatitis, skin pruritus, furuncle and phyma, traumatic injury.

Herba Iridis japonicae: [nature and flavor] are bitter; Cold.[function cures mainly] reducing swelling and alleviating pain; Heat-clearing and toxic substances removing.Main hepatitis; Hepatomegaly; Pain in the hepatic region; Stomachache; Laryngopharynx swelling and pain; Have blood in stool.

Herba Sedi Aizoon: [nature and flavor] sweet, micro-acid, flat.[function cures mainly] dissipating blood stasis stops blooding, analgesia of calming the nerves.For thrombocytopenic purpura, epistaxis, spits blood, spitting of blood, gingival hemorrhage, digestive tract hemorrhage, metrorrhagia, cardiopalmus, irritated insomnia; Traumatic injury is controlled in external, traumatic hemorrhage, burn and scald.

Cauliset Folium Piperis Hancei: nature and flavor Guangzhou army " conventional Chinese herbal medicine handbook ": " pungent, temperature." [function cures mainly] be Guangzhou army " conventional Chinese herbal medicine handbook " 1.: " wind-damp dispelling, strong waist knee joint.Dispelling the wind and dampness pathogens pain, wind and cold osteodynia, weakness of the waist and knees, amyotrophy, cough and asthma." 2. " Guangxi Chinese herbal medicine ": " dispelling the wind and dampness pathogens osteodynia, paralysis of the limbs, cold, cough and asthma, the cold pain of abdomen." 3. " the practical Chinese herbal medicine in Guangxi newly selects ": " reducing swelling and alleviating pain, wind dispelling is trembled with fear, and stimulates the menstrual flow.Control traumatic injury, venom."

Fructus Seu Herba Pubescentis: nature and flavor are bitter, cool.[function cures mainly] heat-clearing and toxic substances removing, antiinflammatory diuretic.Cure mainly cold, fever, parotitis, bronchitis, acute pyelonephritis, orchitis, bubble rash, furuncle, colicky.

Holotrichia diomphalia Bates: [nature and flavor] are " herbal classic " 1.: " salty in the mouth, tepor." 2. " not Lu ": " be slightly cold." [return through] " book on Chinese herbal medicine converge speech ": " enters liver channel of foot-Jueyin." [function cures mainly] removing blood stasis, clots absorbing, eliminating stagnation, lactogenesis.Control and lose stasis of blood pain, gout, tetanus, sore throat, corneal nebula, erysipelas, carbuncle, anal fistula.1. " herbal classic ": " main stagnant blood blood stasis stagnated QI, the full pain of broken folding blood stagnating in the hypochondriac region heavily fortified point, the moon closes, excessive skin, blue or green nebula tunica albuginea in order." 2. " not Lu ": " be treated to spit blood and not to be gone and broken bone Wei rolls over blood agglomeration, plug in incised wound at breast abdomen, puerperal invasion by pathogenic cold, lower milk." 3. " property of medicine opinion ": " juice drips in order, and removing nebula hinders, main blood, pain relieving." 4. supplement to the Herbal: " main red white trip rash, rash is frayed, and broken Holotrichia diomphalia Bates extracting juice is coated with it." 5. " Japan hanako materia medica ": " can apply malignant boil."

Herba Homalocladii Platycladii: [nature and flavor] sweet acid, is slightly cold.1. " Guangxi Chinese medicinal herbal ": " lightly seasoned puckery, cold nature is nontoxic." 2. " Quanzhou book on Chinese herbal medicine ": " sour in the mouth is micro-sweet, and property is put down, nontoxic." [return through] enters the heart, liver, spleen channel.1. " Guangxi Chinese medicinal herbal ": " enter the heart, liver two warp." 2. " Quanzhou book on Chinese herbal medicine ": " enters the heart, liver, swollen warp." [function cures mainly] heat-clearing and toxic substances removing, dissipating blood stasis for subsidence of swelling.Control swollen ulcer drug, traumatic injury, Serpentis, insect bite wound.1. " Guangxi Chinese medicinal herbal ": " detumescence of drawing out pus by applying a plaster to the affected part.Control poisonous snake and Scolopendra stings." 2. " Quanzhou book on Chinese herbal medicine ": " heat-clearing and toxic substances removing, moves back Huang detumescence, promoting the circulation of blood blood stasis removing, tissue regeneration promoting pain relieving.Control swollen ulcer drug, traumatic injury, venom."

Cortex Cinnamomi: [nature and flavor] are pungent, sweet, hot greatly.[return through] returns kidney, spleen, the heart, Liver Channel.It is supporing yang that [function cures mainly] mends fire, let the fire back to its origin, dispersing cold for relieving pain, promoting blood circulation to restore menstrual flow.For sexual impotence, cold womb, chills and pain of the waist and kness, suffers from a deficiency of the kidney and breathes heavily, dizziness due to yang deficiency, conjunctival congestion pharyngalgia, trusted subordinate's cold type of pain, and deficiency and coldness is vomited and diarrhoea, colic of cold type, renal mass, amenorrhea, dysmenorrhea.

Semen Sinapis Albae: [nature and flavor] are pungent, temperature.1. " product remittance essence is wanted ": " acrid in the mouth, warm in nature, nontoxic." 2. Yao can become " food book on Chinese herbal medicine ": " is pungent, heat." 3. " herbal classic is met former ": " is pungent, temperature." [return through] enters lung, stomach warp.1. " Thunder God concocts property of medicine solution ": " enter lung, stomach two warp." 2. " book on Chinese herbal medicine newly organized ": " enters the warp of liver, spleen, lung, stomach, the heart and envelope." [function cures mainly] promoting the circulation of QI eliminating phlegm, warming spleen and stomach for dispelling cold, removing obstruction in the collateral to relieve pain.Control phlegm retention cough with asthma, fullness and distention in the chest and hypochondrium pain, regurgitation is vomitted, aphasia due to apoplexy, and limbs arthralgia pain is numb, beriberi, carbuncle of yin nature, toxic swelling, treating swelling and pain by traumatic injury.

Herba Kalimeridis: [nature and flavor] are pungent, bitter, cold.[function cures mainly] heat-clearing and toxic substances removing, dissipating blood stasis stops blooding, removing food stagnancy.For cat fever, cough, acute pharyngitis, tonsillitis, mumps, infectious hepatitis, taste-blindness rate, infantile malnutrition, enteritis, dysentery, spits blood, metrorrhagia, menoxenia; External is controlled furuncle and is swollen and ache, mastitis, traumatic hemorrhage.

Rhizoma Tupistrae pachynemae: [nature and flavor] are pungent, bitter, temperature.[function cures mainly] warming spleen and stomach for dispelling cold, promoting the circulation of QI to relieve pain.For stomachache, treating swelling and pain by traumatic injury.

Lignum cinnamomi camphorae: [nature and flavor] are pungent; Temperature.[function cures mainly] expelling wind and cold; Stomach warming and in; Regulating QI to relieve pain.Main coldness and pain in the epigastrium; Cold-damp is vomited and diarrhoea; Stagnation of QI abdominal distention; Beriberi.

Fructus Zanthoxyli Plansipini: [nature and flavor] pungent, micro-hardship, temperature.[function cures mainly] warming middle-JIAO is regulated the flow of vital energy, expelling wind and removing dampness, promoting blood circulation and stopping pain.Root, really: stomach abdomen cold type of pain, gastrointestinal dysfunction, ascariasis is suffered from abdominal pain, headache due to common cold, wind and cold cough with asthma, rheumatic arthritis, venom; Leaf: treating swelling and pain by traumatic injury is controlled in external, carbuncle sore tumefacting virus, skin pruritus.

Radix Osmorhizae Laxae: [nature and flavor] are pungent, temperature.[function cures mainly] cold expelling is delivered, pain relieving.Cure mainly anemofrigid cold, headache, the diseases such as general aching.

Rhizoma panacis majoris: [nature and flavor] are bitter sweet, cold.1. " Bencao Congxin ": " bitter, cold, micro-sweet." 2. " medical material compilation of data ": " taste is slightly bitter, is with puckery, is slightly cold, nontoxic." 3. " Traditional Chinese Medicine in Sichuan will ": " is bitter, flat, micro-sweet, nontoxic." [return through] " Traditional Chinese Medicine in Sichuan will ": " enters liver, stomach two warp." [function cures mainly] yin nourishing, lung heat clearing, dissipating blood stasis, hemostasis, analgesic therapy.Control calentura excessive thirst, cough due to yin deficiency, consumptive disease wound is spitted blood, epistaxis, pharyngalgia, rheumatic arthritis, infantile convulsion, traumatic injury.

Radix Jasmini Giraldii: [nature and flavor] micro-hardship, puckery, temperature.[function cures mainly] blood circulation promoting and blood stasis dispelling, granulation promoting, convergence.Cure mainly traumatic injury, stagnant in blood stasis, fracture, knife injury.

Radix Glehniae: [nature and flavor] sweetness and bitterness is light, cool.1. " herbal classic is met former ": " sweet light, cold in nature, nontoxic." 2. " Bencao Congxin ": " sweetness and bitterness is lightly seasoned, is slightly cold." [return through] enters lung, spleen channel.1. " book on Chinese herbal medicine must be joined ": " enter meridian of Hand-TAI YIN." 2. " book on Chinese herbal medicine brief points ": " starts with, meridian of Foot-TAI YIN." [function cures mainly] nourishing YIN and clearing away lung-heat, expelling phlegm for arresting cough.Control lung-heat type cough, chronic consumptive disease chronic cough, the moon hinders dry pharynx, thirsty.1. " Bencao Congxin ": " specially tonifying the lung is cloudy, and lung heat clearing fire, controls chronic cough consumptive lung disease." 2. " decoction pieces is newly joined ": " supports lung stomach-Yin, controls phthisical cough expectorant blood." 3. " will planted by northeast medicine ": " controls chronic bronchitis, pulmonary tuberculosis, pulmonary atelectasis, lung abscess etc." 4. " Chinese medicinal herbal ": " supports lung yin, clearing away lung-heat, expelling phlegm for arresting cough.Control deficient fever, the moon hinders cough caused by dryness, thirsty and dry pharynx."

Fructus Aristolochiae Kwangsiensis: [nature and flavor] are " Guangxi Chinese herbal medicine " 1.: " bitter in the mouth, cold in nature." 2. " choosing of Yunnan Chinese herbal medicine ": " is sweet, flat." [function cures mainly] be " register planted by Guangxi medicine " 1.: " is refrigerant brings down a fever, removing toxic substances.Control dizziness, laryngalgia, stomachache, stomachache, skin ulcer scabies, knife injury, snakebite." 2. " choosing of Yunnan Chinese herbal medicine ": " expelling the stasis for the new, removing heat from blood, promoting the circulation of QI to relieve pain.Treating malaria disease, pulmonary tuberculosis, traumatic injury, flatulence pain."

Folium Baeckeae: [nature and flavor] " Nanning City's medicine will ": " bitter, cold, nontoxic." [function cures mainly] blood stasis removing, pain relieving, diuresis, parasite killing.Control traumatic injury, rheumatalgia, gonorrhea, scabies, tinea pedis.1. " Guangzhou flora ": " control calentura." 2. " Luchuan book on Chinese herbal medicine ": " detumescence, pain relieving, blood stasis removing, parasite killing.Control traumatic injury stupor, scabies, ulcer, venom." 3. " Nanning City's medicine will ": " restrains, parasite killing, hemostasis, pain relieving, granulation promoting.With washing skin infection, pruritus." 4. " Guangxi Chinese medicinal herbal ": " has diuresis promoting effect.Control bladder heat, dysuria, pudendal pruritus, skin steam.Decoct that washing skin is rottenly itched, eczema; Leaf, smashes deposited, controls Scolopendra wound; Branch and leaf, steam oil, controls skin ulcer leprosy etc."

Herba Zornia Diphyllae: [chemical analysis] herb is containing flavonoid glycoside, phenols, aminoacid.[nature and flavor] are sweet, cool.1. " the SHENGCAO property of medicine is standby to be wanted ": " taste is sweet, warm in nature." 2. " book on Chinese herbal medicine asks former ": " is sweet, flat." 3. " Guangdong Chinese medicine " II: " is flat, cool in nature." [function cures mainly] heat clearing away, removing toxic substances, blood stasis removing.Cure cold, high fever tic, diarrhoea, jaundice, dysentery, infantile malnutrition, laryngalgia, conjunctival congestion, furuncle swelling toxin, mastitis.

Rhizoma Osmundae: [nature and flavor] are bitter; Puckery; Be slightly cold.[return through] liver; Stomach warp.[function cures mainly] parasite killing; Heat clearing away; Removing toxic substances; Cooling blood for hemostasis.Main anemopyretic cold; Warm skin eruption; Spit blood; Hemoptysis; Epistaxis; Have blood in stool; Metrorrhagia; Dysentery; The intestinal parasitic diseases such as leukorrhagia and hook, ascarid, cestode.

Cortex Syringae: [nature and flavor] " Chinese herbal medicine handbook is commonly used in northeast ": " bitter, be slightly cold." [function cures mainly] " Jilin Chinese herbal medicine ": " antiinflammatory, antitussive.Diuretic.Control rale to breathe heavily and cough, sudden cardiac edema."

Herba Chelidonii: [nature and flavor] toil, tepor.1. herbal for Relief of Famines: " bitter in the mouth is micro-peppery." 2. " Traditional Chinese Medicine in Sichuan will ": " slightly warm in nature, bitter in the mouth is pungent, poisonous." 3. " the conventional Chinese herbal medicine in the north ": " bitter in the mouth, cold in nature, poisonous." [function cures mainly] eases pain, cough-relieving, and diuresis is detoxified.Control gastrointestinal distress, jaundice, edema, scabies skin ulcer swells, snake bite and insect sting.1. " will planted by middle traditional Chinese medicines ": " control gastrointestinal distress and ulcer.External is scabies medicine and repellent, is coated with it to give birth to juice." 2. " Shanxi Chinese medicinal herbal ": " lower heart-fire, brings down a fever antipyretic, anti-inflammation and sterilization, antalgic and sedative." 3. " Traditional Chinese Medicine in Sichuan will ": " treating the liver hardens, tuberculosis of skin, vitamin B1 deficiency, cholecystopathy and edema jaundice." 4. " Shaanxi Chinese medicinal herbal ": " controls venom, and relieve the pain detumescence." 5. " the conventional Chinese herbal medicine in the north ": " has analgesia, cough-relieving, sterilization, diuresis, separates the merit of sore.Treating acute and chronic gastritis, gastric ulcer, stomachache, dysentery, cough, cirrhotic ascites."

Herba Blumeae Lacerae: [nature and flavor] bitter in the mouth; Cold in nature.[function cures mainly] clearing away heat-fire; Removing toxic substances and promoting subsidence of swelling.Main cough due to lung-heat; Laryngopharynx swelling and pain; Aphtha of the mouth and tongue; Toothache due to stomach-fire; Zha rib; Carbuncle sore tumefacting virus.

Described pharmaceutical composition is only made up of above-mentioned raw materials medical material.

Below adopt embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the implementation procedure reaching technique effect can fully understand and implement according to this.

Embodiment 1 pharmaceutical composition 1

Radix Achyranthis 220g, Radix Bischofiae Javanicae 160g, Flos Rosae Chinensis 220g, Lacca 20g, Radix Lamiophlomidis Rotatae 30g, Herba Lycopi 120g, Radix Rubiae 150g, Herba Lycopodii Obscuri 160g, Huechys sanguinea De Geer. 30g, Folium Lantanae Camarae 20g, Herba Iridis japonicae 30g, Herba Sedi Aizoon 150g, Cauliset Folium Piperis Hancei 170g, Fructus Seu Herba Pubescentis 80g, Holotrichia diomphalia Bates 20g, Herba Homalocladii Platycladii 220g, Cortex Cinnamomi 160g, Semen Sinapis Albae 30g, Herba Kalimeridis 150g, Rhizoma Tupistrae pachynemae 30g, the sub-180g of Lignum cinnamomi camphorae, Fructus Zanthoxyli Plansipini 50g, Radix Osmorhizae Laxae 170g, Rhizoma panacis majoris 80g, Radix Jasmini Giraldii 150g, Radix Glehniae 170g, Fructus Aristolochiae Kwangsiensis 120g, Folium Baeckeae 160g, Herba Zornia Diphyllae 180g, Rhizoma Osmundae 30g, Cortex Syringae 160g, Herba Chelidonii 20g, Herba Blumeae Lacerae 160g.

Its preparation method comprises the following steps:

The first step, is mixed in proportion described raw medicinal material, and adding relative to the determining alcohol of mixture quality 1 times is the ethanol of 80%, reflux 2 hours, extracts, and filters acquisition first extracting solution; It is the ethanol of 80% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 1 times again, reflux 2 hours, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;

Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 1 hour, pulverize, sieve, obtain 300 object micropowders;

3rd step, by the micropowders that second step obtains, adds relative to the microcrystalline Cellulose of its quality 0.01 times, 0.01 times of lactose, the starch of 0.01 times, sieves, mix homogeneously, granulates, dry, adds relative to micropowders quality 0.001 times of magnesium stearate, granulate, tabletting, makes.

Embodiment 2 drug regimen group 2

Radix Achyranthis 260g, Radix Bischofiae Javanicae 160g, Flos Rosae Chinensis 220g, Lacca 10g, Radix Lamiophlomidis Rotatae 20g, Herba Lycopi 120g, Radix Rubiae 160g, Herba Lycopodii Obscuri 170g, Huechys sanguinea De Geer. 20g, Folium Lantanae Camarae 20g, Herba Iridis japonicae 30g, Herba Sedi Aizoon 160g, Cauliset Folium Piperis Hancei 170g, Fructus Seu Herba Pubescentis 90g, Holotrichia diomphalia Bates 20g, Herba Homalocladii Platycladii 220g, Cortex Cinnamomi 120g, Semen Sinapis Albae 30g, Herba Kalimeridis 160g, Rhizoma Tupistrae pachynemae 30g, the sub-160g of Lignum cinnamomi camphorae, Fructus Zanthoxyli Plansipini 30g, Radix Osmorhizae Laxae 160g, Rhizoma panacis majoris 80g, Radix Jasmini Giraldii 170g, Radix Glehniae 180g, Fructus Aristolochiae Kwangsiensis 120g, Folium Baeckeae 170g, Herba Zornia Diphyllae 180g, Rhizoma Osmundae 30g, Cortex Syringae 170g, Herba Chelidonii 30g, Herba Blumeae Lacerae 160g.

Its preparation method comprises the following steps:

Step one: described raw medicinal material is mixed in described ratio, adding relative to the determining alcohol of 4 times, mixture is the ethanol of 80%, be heated to boiling reflux 4 hours, filter, adopt percolation with the speed of 2ml per minute slowly percolation, collect percolate, when being evaporated to 60 DEG C subsequently under vacuum 0.06Mpa, relative density is the mastic of 1.14, spraying dry, the inlet temperature 175 DEG C of spray dryer, leaving air temp 85 DEG C, be ground into powder subsequently, make dried cream powder;

Step 2: the dextrin adding cane sugar powder relative to dried cream powder quality 0.3 times and 0.2 times in the dried cream powder obtained, makes granule, in 50 DEG C of dryings, obtains granule.

Embodiment 3 pharmaceutical composition 3

Radix Achyranthis 250g, Radix Bischofiae Javanicae 170g, Flos Rosae Chinensis 230g, Lacca 20g, Radix Lamiophlomidis Rotatae 30g, Herba Lycopi 130g, Radix Rubiae 150g, Herba Lycopodii Obscuri 170g, Huechys sanguinea De Geer. 30g, Folium Lantanae Camarae 30g, Herba Iridis japonicae 40g, Herba Sedi Aizoon 160g, Cauliset Folium Piperis Hancei 180g, Fructus Seu Herba Pubescentis 80g, Holotrichia diomphalia Bates 20g, Herba Homalocladii Platycladii 220g, Cortex Cinnamomi 160g, Semen Sinapis Albae 30g, Herba Kalimeridis 160g, Rhizoma Tupistrae pachynemae 30g, the sub-170g of Lignum cinnamomi camphorae, Fructus Zanthoxyli Plansipini 40g, Radix Osmorhizae Laxae 170g, Rhizoma panacis majoris 80g, Radix Jasmini Giraldii 150g, Radix Glehniae 170g, Fructus Aristolochiae Kwangsiensis 80g, Folium Baeckeae 180g, Herba Zornia Diphyllae 180g, Rhizoma Osmundae 30g, Cortex Syringae 160g, Herba Chelidonii 30g, Herba Blumeae Lacerae 160g.

Its preparation method is:

The first step, described raw medicinal material is mixed in proportion, put into super micron mill and be ground into the mixed powder that the micron particles of 10 μm of volume average particle size and particle diameter be less than the nano-scale particle composition of 0.1 μm of volume average particle size, described mixed powder powder rate be at least 97%;

Second step, adding relative to the determining alcohol of the quality 4 times of described mixed powder in the mixed powder that the first step obtains is the ethanol of 80%, stirring and dissolving obtains alcoholic solution, alcoholic solution is left standstill 36 hours under the condition of 15 DEG C, adopt percolation with the speed of 2ml per minute slowly percolation, collect percolate, concentrated and dry, and put into super micron mill pulverizing 60 minutes at this, the micron particles of acquisition 10 μm of volume average particle size and particle diameter are less than the mixed powder of the nano-scale particle composition of 0.1 μm of volume average particle size, the powder rate that obtains of described mixed powder is at least 97%,

3rd step, gets mixed powder 5g ~ 10g that second step obtains, adds propylene glycol 10g, add 200ml water for injection, stirs and makes it dissolve, inject water to 1000ml further, then add 1g needle-use activated carbon, fully stirs 40 minutes; Decarbonization filtering; With 0.24 μm of filtering with microporous membrane; Lyophilization obtains sterilized powder, and subpackage embedding, to obtain final product.

Embodiment 4 pharmaceutical composition 4

Radix Achyranthis 300g, Radix Bischofiae Javanicae 160g, Flos Rosae Chinensis 220g, Lacca 20g, Radix Lamiophlomidis Rotatae 30g, Herba Lycopi 140g, Radix Rubiae 160g, Herba Lycopodii Obscuri 170g, Huechys sanguinea De Geer. 30g, Folium Lantanae Camarae 20g, Herba Iridis japonicae 30g, Herba Sedi Aizoon 160g, Cauliset Folium Piperis Hancei 170g, Fructus Seu Herba Pubescentis 80g, Holotrichia diomphalia Bates 20g, Herba Homalocladii Platycladii 220g, Cortex Cinnamomi 130g, Semen Sinapis Albae 30g, Herba Kalimeridis 160g, Rhizoma Tupistrae pachynemae 30g, the sub-160g of Lignum cinnamomi camphorae, Fructus Zanthoxyli Plansipini 40g, Radix Osmorhizae Laxae 160g, Rhizoma panacis majoris 80g, Radix Jasmini Giraldii 160g, Radix Glehniae 160g, Fructus Aristolochiae Kwangsiensis 90g, Folium Baeckeae 180g, Herba Zornia Diphyllae 180g, Rhizoma Osmundae 30g, Cortex Syringae 160g, Herba Chelidonii 30g, Herba Blumeae Lacerae 170g.

Its preparation method is:

Second step, the first step is obtained powder and add in cold water and soak 6 hours, with slow fire boiling, decocting time is 5 hours, decoction liquor is filtered, obtains the first filtrate, and the quality of the water added is 3 times of the powder quality that the first step obtains;

3rd step, filters second step the filtering residue obtained and again adds in cold water, with slow fire boiling 3 hours, filters acquisition second filtrate, and the quality of the water added is 3 times of the powder quality that second step obtains;

4th step, the second filtrate mixing that the first filtrate obtain second step and the 3rd step obtain, concentrating under reduced pressure, except anhydrating, dry, pulverize powdered, and granularity is 150 orders;

5th step, in the powder that described 4th step obtains, add starch, the percentage by weight of described starch in described powder is 15%, by the material pouch after mixing or packing box subpackage.

The toxicity test of pharmaceutical composition

1. with the pharmaceutical composition 1 of the embodiment of the present invention 1 for object, 150 times of clinical consumption per day give white mouse large enteral dispensing, observe 7.The all animals of result are strong deposits, and its activity, diet, hair, Excreta are no abnormal, have no toxic reaction.Irritation test is carried out to white mouse vagina and damaged skin, there are no irritative response and other untoward reaction.Toxicity test proves, this medicine does not have toxic action and untoward reaction, and clinical practice is safe and reliable.

2. test method: select 20 healthy mices, female, each 10 of hero, with the pharmaceutical composition 2 of the embodiment of the present invention 2 for object, dose design is first phase in every 5 days, each issue dosage is respectively 0.10LD50,0.15LD50,0.22LD50,0.34LD 50,0.50LD50, the LD 50 that is female, male mice of this sample be 5000m part/k part BW (five dosage is 500,750,1100,1700,2500m part/k part BW).Within every 5 days, weigh once, adjustment dosage, by 0.1ml/10 part BW per os gavage.After 20 days, animal occurs without death condition, off-test, and by ascending-dose to tested material after 20 days, female, buck all occurs without death condition.Illustrate that this pharmaceutical composition does not have cumulative toxicity.

Contrast test

Linyi chicken raiser, has nearly 1000 chickens to occur following symptom: bradykinesia, the swelling of lower limb conjunctura, anorexia, exhaustion and diarrhoea in February, 2014.Be diagnosed as chicken gout.

Now get 300 ill chickens to carry out treatment contrast test, be divided into five groups at random, embodiment 1 group, embodiment 2 groups, embodiment 3 groups, embodiment 4 groups and matched group, often organize 60.Keep environment of feeding consistent.

Embodiment 1 group: this group adopts the pharmaceutical composition 1 of embodiment 1 to treat.Medicine is mixed in conventional feed according to the ratio of 2:100, carries out feeding 3 days.

Embodiment 2 groups: this group adopts the pharmaceutical composition 2 of embodiment 2 to treat.Medicine is mixed in conventional feed according to the ratio of 2:100, carries out feeding 3 days.

Embodiment 3 groups: this group adopts the pharmaceutical composition 3 of embodiment 1 to treat.Medicine is carried out the injection of wing portion according to per kilogram of body weight 1.5-2 ten thousand unit, and conventional feed carries out feeding 3 days.

Embodiment 4 groups: this group adopts the pharmaceutical composition 4 of embodiment 1 to treat.Medicine is mixed in conventional feed according to the ratio of 2:100, carries out feeding 3 days.

Matched group: throw and take rhubarb soda tablet, every kg body weight 1.5 (containing Radix Et Rhizoma Rhei 0.15 gram, sodium bicarbonate 0.15 gram), severe disease chicken is by only directly throwing clothes, and all the other spices, every day 2 times, are used in conjunction 3 days.While the rhubarb soda tablet that comes into operation, in conventional feed, add Bao Shu Novi, AD3 powder, and give sufficient drinking-water.

Curative effect is passed judgment on

Recovery from illness: symptom disappears completely, action recovers normal; Effective: symptom disappears substantially, action is basic recovers normal; Invalid: symptom does not disappear or do not feel any better, there is more severe tendency.

Result

Table 1 is the treatment situation contrast of each group

Group	Recovery from illness	Effectively	Invalid
				Embodiment 1 group	59（98.33%）	1（1.67%）	0（0%）
Embodiment 2 groups	59（98.33%）	1（1.67%）	0（0%）
				Embodiment 3 groups	60（100%）	0（0%）	0（0%）
Embodiment 4 groups	60（100%）	0（0%）	0（0%）
				Matched group	20（0%）	10（0%）	30（50%）

As can be seen from Table 1, the treatment situation of four embodiment groups is all better than matched group, it can thus be appreciated that, pharmaceutical composition of the present invention, treatment chicken gout, good effect.

Model case: Liaocheng of Shandong Province chicken raiser, has 500 chickens to occur chicken gout epidemic situation, dead 50, symptom: be namely judged as chicken gout.Select 200 sick chickens, adopt the pharmaceutical composition 2 of embodiment 2 to treat.Medicine is mixed in conventional feed according to the ratio of 2:100, carries out feeding 3 days.After treatment, have 200 fowl disease diseases all to disappear, recovery from illness, cure rate is 100%.

The foregoing is only preferred embodiment of the present invention, not in order to limit the present invention, within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.

Claims

1. be used for the treatment of the pharmaceutical composition of chicken gout, it is characterized in that, described pharmaceutical composition comprises following raw medicinal material: Radix Achyranthis, Radix Bischofiae Javanicae, Flos Rosae Chinensis, Lacca, Radix Lamiophlomidis Rotatae, Herba Lycopi, Radix Rubiae, Herba Lycopodii Obscuri, Huechys sanguinea De Geer., Folium Lantanae Camarae, Herba Iridis japonicae, Herba Sedi Aizoon, Cauliset Folium Piperis Hancei, Fructus Seu Herba Pubescentis, Holotrichia diomphalia Bates, Herba Homalocladii Platycladii, Cortex Cinnamomi, Semen Sinapis Albae, Herba Kalimeridis, Rhizoma Tupistrae pachynemae, Lignum cinnamomi camphorae, Fructus Zanthoxyli Plansipini, Radix Osmorhizae Laxae, Rhizoma panacis majoris, Radix Jasmini Giraldii, Radix Glehniae, Fructus Aristolochiae Kwangsiensis, Folium Baeckeae, Herba Zornia Diphyllae, Rhizoma Osmundae, Cortex Syringae, Herba Chelidonii, Herba Blumeae Lacerae.

2. the pharmaceutical composition being used for the treatment of chicken gout according to claim 1, is characterized in that, in described pharmaceutical composition, the parts by weight of each raw medicinal material are: Radix Achyranthis 20-30 weight portion, Radix Bischofiae Javanicae 15-20 weight portion, Flos Rosae Chinensis 20-25 weight portion, Lacca 1-3 weight portion, Radix Lamiophlomidis Rotatae 2-4 weight portion, Herba Lycopi 10-15 weight portion, Radix Rubiae 10-20 weight portion, Herba Lycopodii Obscuri 15-20 weight portion, Huechys sanguinea De Geer. 2-4 weight portion, Folium Lantanae Camarae 1-4 weight portion, Herba Iridis japonicae 2-5 weight portion, Herba Sedi Aizoon 10-20 weight portion, Cauliset Folium Piperis Hancei 15-25 weight portion, Fructus Seu Herba Pubescentis 7-13 weight portion, Holotrichia diomphalia Bates 1-3 weight portion, Herba Homalocladii Platycladii 20-25 weight portion, Cortex Cinnamomi 10-20 weight portion, Semen Sinapis Albae 2-4 weight portion, Herba Kalimeridis 10-20 weight portion, Rhizoma Tupistrae pachynemae 2-4 weight portion, the sub-15-25 weight portion of Lignum cinnamomi camphorae, Fructus Zanthoxyli Plansipini 3-5 weight portion, Radix Osmorhizae Laxae 15-25 weight portion, Rhizoma panacis majoris 6-13 weight portion, Radix Jasmini Giraldii 10-20 weight portion, Radix Glehniae 15-20 weight portion, Fructus Aristolochiae Kwangsiensis 8-15 weight portion, Folium Baeckeae 15-20 weight portion, Herba Zornia Diphyllae 12-22 weight portion, Rhizoma Osmundae 2-4 weight portion, Cortex Syringae 10-20 weight portion, Herba Chelidonii 2-4 weight portion, Herba Blumeae Lacerae 15-20 weight portion.

3. the pharmaceutical composition being used for the treatment of chicken gout according to claim 1 and 2, is characterized in that, in described pharmaceutical composition, the parts by weight of each raw medicinal material are: Radix Achyranthis 25-30 weight portion, Radix Bischofiae Javanicae 15-20 weight portion, Flos Rosae Chinensis 20-25 weight portion, Lacca 1-3 weight portion, Radix Lamiophlomidis Rotatae 2-4 weight portion, Herba Lycopi 10-15 weight portion, Radix Rubiae 15-20 weight portion, Herba Lycopodii Obscuri 15-20 weight portion, Huechys sanguinea De Geer. 2-4 weight portion, Folium Lantanae Camarae 1-4 weight portion, Herba Iridis japonicae 2-5 weight portion, Herba Sedi Aizoon 15-20 weight portion, Cauliset Folium Piperis Hancei 15-20 weight portion, Fructus Seu Herba Pubescentis 7-13 weight portion, Holotrichia diomphalia Bates 1-3 weight portion, Herba Homalocladii Platycladii 20-25 weight portion, Cortex Cinnamomi 10-15 weight portion, Semen Sinapis Albae 2-4 weight portion, Herba Kalimeridis 15-20 weight portion, Rhizoma Tupistrae pachynemae 2-4 weight portion, the sub-15-20 weight portion of Lignum cinnamomi camphorae, Fructus Zanthoxyli Plansipini 3-5 weight portion, Radix Osmorhizae Laxae 15-20 weight portion, Rhizoma panacis majoris 6-13 weight portion, Radix Jasmini Giraldii 15-20 weight portion, Radix Glehniae 15-20 weight portion, Fructus Aristolochiae Kwangsiensis 8-15 weight portion, Folium Baeckeae 15-20 weight portion, Herba Zornia Diphyllae 12-22 weight portion, Rhizoma Osmundae 2-4 weight portion, Cortex Syringae 15-20 weight portion, Herba Chelidonii 2-4 weight portion, Herba Blumeae Lacerae 15-20 weight portion.

4. the pharmaceutical composition being used for the treatment of chicken gout according to any one of claim 1-3, is characterized in that, in described pharmaceutical composition, the parts by weight of each raw medicinal material are: Radix Achyranthis 25 weight portion, Radix Bischofiae Javanicae 17 weight portion, Flos Rosae Chinensis 23 weight portion, Lacca 2 weight portion, Radix Lamiophlomidis Rotatae 3 weight portion, Herba Lycopi 13 weight portion, Radix Rubiae 15 weight portion, Herba Lycopodii Obscuri 17 weight portion, Huechys sanguinea De Geer. 3 weight portion, Folium Lantanae Camarae 3 weight portion, Herba Iridis japonicae 4 weight portion, Herba Sedi Aizoon 16 weight portion, Cauliset Folium Piperis Hancei 18 weight portion, Fructus Seu Herba Pubescentis 8 weight portion, Holotrichia diomphalia Bates 2 weight portion, Herba Homalocladii Platycladii 22 weight portion, Cortex Cinnamomi 16 weight portion, Semen Sinapis Albae 3 weight portion, Herba Kalimeridis 16 weight portion, Rhizoma Tupistrae pachynemae 3 weight portion, Lignum cinnamomi camphorae 17 weight portions, Fructus Zanthoxyli Plansipini 4 weight portion, Radix Osmorhizae Laxae 17 weight portion, Rhizoma panacis majoris 8 weight portion, Radix Jasmini Giraldii 15 weight portion, Radix Glehniae 17 weight portion, Fructus Aristolochiae Kwangsiensis 8 weight portion, Folium Baeckeae 18 weight portion, Herba Zornia Diphyllae 18 weight portion, Rhizoma Osmundae 3 weight portion, Cortex Syringae 16 weight portion, Herba Chelidonii 3 weight portion, Herba Blumeae Lacerae 16 weight portion.

5. the pharmaceutical composition being used for the treatment of chicken gout according to any one of claim 1-4, is characterized in that, in described pharmaceutical composition, the parts by weight of each raw medicinal material are: Radix Achyranthis 30 weight portion, Radix Bischofiae Javanicae 16 weight portion, Flos Rosae Chinensis 22 weight portion, Lacca 2 weight portion, Radix Lamiophlomidis Rotatae 3 weight portion, Herba Lycopi 14 weight portion, Radix Rubiae 16 weight portion, Herba Lycopodii Obscuri 17 weight portion, Huechys sanguinea De Geer. 3 weight portion, Folium Lantanae Camarae 2 weight portion, Herba Iridis japonicae 3 weight portion, Herba Sedi Aizoon 16 weight portion, Cauliset Folium Piperis Hancei 17 weight portion, Fructus Seu Herba Pubescentis 8 weight portion, Holotrichia diomphalia Bates 2 weight portion, Herba Homalocladii Platycladii 22 weight portion, Cortex Cinnamomi 13 weight portion, Semen Sinapis Albae 3 weight portion, Herba Kalimeridis 16 weight portion, Rhizoma Tupistrae pachynemae 3 weight portion, Lignum cinnamomi camphorae 16 weight portions, Fructus Zanthoxyli Plansipini 4 weight portion, Radix Osmorhizae Laxae 16 weight portion, Rhizoma panacis majoris 8 weight portion, Radix Jasmini Giraldii 16 weight portion, Radix Glehniae 16 weight portion, Fructus Aristolochiae Kwangsiensis 9 weight portion, Folium Baeckeae 18 weight portion, Herba Zornia Diphyllae 18 weight portion, Rhizoma Osmundae 3 weight portion, Cortex Syringae 16 weight portion, Herba Chelidonii 3 weight portion, Herba Blumeae Lacerae 17 weight portion.

6. the pharmaceutical composition being used for the treatment of chicken gout according to any one of claim 1-5, is characterized in that, the dosage form of described pharmaceutical composition is tablet, and its preparation method comprises the following steps:

7. the pharmaceutical composition being used for the treatment of chicken gout according to any one of claim 1-5, is characterized in that, the dosage form of described pharmaceutical composition is granule, and its preparation method comprises the following steps:

8. the preparation method being used for the treatment of the pharmaceutical composition of chicken gout as described in any one of claim 1-5, is characterized in that, the dosage form of described pharmaceutical composition is injection, and its preparation method comprises the following steps:

9. the preparation method being used for the treatment of the pharmaceutical composition of chicken gout as described in any one of claim 1-5, is characterized in that, the dosage form of described pharmaceutical composition is powder, and its preparation method comprises the following steps: