CN105381356A - Powder for preventing and treating plecoglossus altivelis hemorrhagic disease and preparation method thereof - Google Patents

Powder for preventing and treating plecoglossus altivelis hemorrhagic disease and preparation method thereof Download PDF

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Publication number
CN105381356A
CN105381356A CN201510970877.8A CN201510970877A CN105381356A CN 105381356 A CN105381356 A CN 105381356A CN 201510970877 A CN201510970877 A CN 201510970877A CN 105381356 A CN105381356 A CN 105381356A
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China
Prior art keywords
parts
radix
herba
powder
hemorrhagic disease
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CN201510970877.8A
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Chinese (zh)
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王芬
李洪
孙明
王亮
宋辉
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Qingdao Haizhiyuan Intelligent Technology Co Ltd
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Qingdao Haizhiyuan Intelligent Technology Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/906—Zingiberaceae (Ginger family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/728—Hyaluronic acid
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/14—Alkali metal chlorides; Alkaline earth metal chlorides
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/618—Molluscs, e.g. fresh-water molluscs, oysters, clams, squids, octopus, cuttlefish, snails or slugs
    • A—HUMAN NECESSITIES
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/11—Pteridophyta or Filicophyta (ferns)
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    • A61K36/18—Magnoliophyta (angiosperms)
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Abstract

The invention belongs to the technical field of aquaculture, relates to powder for preventing and treating a plecoglossus altivelis hemorrhagic disease and further relates to a preparation method of the powder for preventing and treating the plecoglossus altivelis hemorrhagic disease. The powder for preventing and treating the plecoglossus altivelis hemorrhagic disease is prepared from, by mass, 37-44 parts of sweetgum resin, 28-36 parts of rhizoma dryopteris crassirhizomae, 28-36 parts of spina gleditsiae, 27-35 parts of clinopodium megalanthum, 27-33 parts of Indian epimeredi herbs, 9-15 parts of cicada slough, 23-30 parts of aconitum gymnandrum, 23-30 parts of dried lacquer, 22-30 parts of mulberry leaves, 21-29 parts of peucedani decursivi radix, 20-28 parts of ophiopogon japonicus, 20-28 parts of glutinosae rice roots, 18-28 parts of bitter gourd, 19-27 parts of portulaca oleracea, 17-26 parts of elecampane inula root, 16-26 parts of tree peony bark, 16-25 parts of sophora flavescens, 14-25 parts of reed rhizomes and the like. The powder is used for preventing and treating the plecoglossus altivelis hemorrhagic disease.

Description

Powder of control fragrant fish hemorrhagic disease and preparation method thereof
Technical field
The invention belongs to technical field of aquaculture, particularly relate to a kind of powder preventing and treating fragrant fish hemorrhagic disease; The invention still further relates to a kind of preparation method of powder of above-mentioned control fragrant fish hemorrhagic disease.
Background technology
The most pressing issues that the sharp increase of population brings provide food for the mankind, and aquatic products are as a class high protein, low-fat high value food in food, and people increase severely to its demand nature and day.Fragrant fish body is long and narrow and flat-sided, little and kiss point, and the large eye of mouth is little, and back of the body edge is grey black, both sides and abdominal part are white, and tail bifurcated, without hard sour jujube, have a little adipose fin after dorsal fin, time fresh and alive, each fin is faint yellow, and there is the yellow mottle in a place top of abdomeinal fin, fragrant fish kiss end is lower curved, and form Herba Gelsemii Elegantis, respectively there is a projection lower neck front end, become significantly depression between two projections, lead up and down and respectively have the flat closely-pitched of a line width, can be movable, and be born on skin, vomer anodontia, tool tooth on jawbone and tongue.Whole body all has tiny cycloid scale except head, tool adipose fin, and body length can reach 30 cm, and fragrant fish oppresses delicate greasiness, delicious and savory, and being first-class edible fish, is famous and precious economic fish, have the good reputation of " kings of fresh-water fishes ".Fragrant fish is because meat is tender, delicious, it is Japanese to be deeply subject to peculiar fragrance, Taiwan consumer likes, and has very high economic worth.In recent years, the some areas such as Fujian, Zhejiang and Hebei had started a burst of cultivation upsurge, and according to incompletely statistics, the fragrant fish cultivation quantity that only Fujian, two places, Zhejiang are annual is more than 6000 tons.
Hemorrhagic disease is the common disease of fragrant fish, and its pathogen is streptococcus.The cardinal symptom of fragrant fish hemorrhagic disease is: eyeball blood stasis is given prominence to, and the gill cover is rubescent, veutro petechial hemorrhage, and anus is red and swollen, inflammatory bowel, and long-pending have ascites, and sick fish swimming is slow, does not eat feedstuff.The morbidity water temperature of this disease is 25 ~ 28 DEG C, is usually popular in summer high temperature season, can causes the mortality of fragrant fish.Current treatment fragrant fish hemorrhagic disease typically use the conventional medicine such as norfloxacin or erythromycin, cure rate is low, large to fragrant fish infringement, and contaminated environment, is unfavorable for the sustainable health development of culture fishery.
Summary of the invention
An object of the present invention is to provide a kind of powder preventing and treating fragrant fish hemorrhagic disease, and its raw material components is green pure natural material, has good prevention and therapy effect to fragrant fish hemorrhagic disease.
In order to solve the problems of the technologies described above, the present invention by the following technical solutions, a kind of powder preventing and treating fragrant fish hemorrhagic disease, be made up of each component of following masses number: Resina Liquidambaris 37-44 part, Rhizoma Dryopteris Crassirhizomatis 28-36 part, Spina Gleditsiae 28-36 part, Fructus Cnidii 27-35 part, Herba Epimeredis Indicae 27-33 part, Periostracum Cicadae 9-15 part, Radix aconiti gymnandri 23-30 part, Resina Toxicodendri 23-30 part, Folium Mori 22-30 part, RADIX PEUCEDANI 21-29 part, Radix Ophiopogonis 20-28 part, Radix Oryzae Glutinosae 20-28 part, Fructus Momordicae charantiae 18-28 part, Herba Portulacae 19-27 part, Radix Inulae 17-26 part, Cortex Moutan 16-26 part, Radix Sophorae Flavescentis 16-25 part, Rhizoma Phragmitis 14-25 part, Herba Astragali Melilotoidis (Herba Astragali Sinici) 14-21 part, phellodendron bark 13-21 part, Rhizoma Kaempferiae 12-20 part, Herba Houttuyniae 11-18 part, Herba Plantaginis 10-17 part, Bulbus Allii 7-15 part, bamboo salt 10-18 part, hyaluronic acid 2-5 part, conch meal 5-9 part, Oleum menthae 6-13 part, xanthan gum 3-5 part.
Preferably, the powder of described control fragrant fish hemorrhagic disease, be made up of each component of following masses number: Resina Liquidambaris 39-42 part, Rhizoma Dryopteris Crassirhizomatis 30-34 part, Spina Gleditsiae 31-33 part, Fructus Cnidii 30-32 part, Herba Epimeredis Indicae 29-30 part, Periostracum Cicadae 11-13 part, Radix aconiti gymnandri 25-28 part, Resina Toxicodendri 25-28 part, Folium Mori 25-27 part, RADIX PEUCEDANI 24-26 part, Radix Ophiopogonis 23-25 part, Radix Oryzae Glutinosae 23-25 part, Fructus Momordicae charantiae 21-25 part, Herba Portulacae 22-24 part, Radix Inulae 20-23 part, Cortex Moutan 20-22 part, Radix Sophorae Flavescentis 20-21 part, Rhizoma Phragmitis 18-21 part, Herba Astragali Melilotoidis (Herba Astragali Sinici) 17-18 part, phellodendron bark 15-18 part, Rhizoma Kaempferiae 15-17 part, Herba Houttuyniae 14-15 part, Herba Plantaginis 13-14 part, Bulbus Allii 11-12 part, bamboo salt 13-15 part, hyaluronic acid 3-4 part, conch meal 6-8 part, Oleum menthae 9-12 part, xanthan gum 3-5 part.
Preferably, the powder of described control fragrant fish hemorrhagic disease, be made up of each component of following masses number: Resina Liquidambaris 40 parts, Rhizoma Dryopteris Crassirhizomatis 32 parts, Spina Gleditsiae 32 parts, Fructus Cnidii 31 parts, Herba Epimeredis Indicae 30 parts, Periostracum Cicadae 12 parts, Radix aconiti gymnandri 27 parts, Resina Toxicodendri 27 parts, 26 parts, Folium Mori, RADIX PEUCEDANI 25 parts, Radix Ophiopogonis 24 parts, Radix Oryzae Glutinosae 24 parts, 23 parts, Fructus Momordicae charantiae, Herba Portulacae 23 parts, Radix Inulae 22 parts, Cortex Moutan 21 parts, Radix Sophorae Flavescentis 20 parts, Rhizoma Phragmitis 20 parts, Herba Astragali Melilotoidis (Herba Astragali Sinici) 18 parts, phellodendron bark 17 parts, Rhizoma Kaempferiae 16 parts, Herba Houttuyniae 15 parts, Herba Plantaginis 13 parts, 11 parts, Bulbus Allii, bamboo salt 14 parts, hyaluronic acid 4 parts, conch meal 7 parts, Oleum menthae 10 parts, xanthan gum 4 parts.
Usage and dosage: the powder evenly throwing in 30-50g control of the present invention fragrant fish hemorrhagic disease in water body per ton, once a day.
Another object of the present invention is to provide a kind of preparation method of powder of above-mentioned control fragrant fish hemorrhagic disease, and the preparation method of the powder of this control fragrant fish hemorrhagic disease comprises the following steps:
(1) take Resina Liquidambaris, Rhizoma Dryopteris Crassirhizomatis and Spina Gleditsiae according to proportioning, pulverize putting into pulverizer after Resina Liquidambaris, Rhizoma Dryopteris Crassirhizomatis and Spina Gleditsiae mix homogeneously and cross 100 mesh sieves, obtaining comminuted powder;
(2) by mass concentration be 50% ethanol add in Chinese medicine extracting tank, ethanol consumption is 10 times of the comminuted powder weight of step (1) gained, open and stir, the comminuted powder of step (1) gained is added in Chinese medicine extracting tank, temperature of charge in Chinese medicine extracting tank is warming up to 75-80 DEG C of constant temperature and extracts 30-40min, 100 orders cross leaching filtrate, and filtering residue returns in Chinese medicine extracting tank and repeats to extract once, 100 orders cross leaching filtrate, merge twice gained filtrate;
(3) Fructus Cnidii, Herba Epimeredis Indicae, Folium Mori, RADIX PEUCEDANI, Radix Ophiopogonis, Radix Oryzae Glutinosae, Fructus Momordicae charantiae, Rhizoma Phragmitis, Herba Astragali Melilotoidis (Herba Astragali Sinici), Herba Houttuyniae, Herba Plantaginis and Bulbus Allii is taken according to proportioning, gross weight is designated as 1 part, add 8 parts of purified water, 20-30 DEG C is soaked 6-9h, obtains soak;
(4) boil 2h after the soak that step (3) obtains being heated to boiling, be separated and take out fried liquid, continue the purified water adding 4 parts in medical material, continue to boil 1h after being heated to boiling, merge twice fried liquid and be extracting solution;
(5) take Periostracum Cicadae, Radix aconiti gymnandri, Resina Toxicodendri, Herba Portulacae, Radix Inulae, Cortex Moutan, Radix Sophorae Flavescentis, phellodendron bark and Rhizoma Kaempferiae respectively according to proportioning, load ball mill grinding 2h, cross 80 mesh sieves, obtain grounds travel;
(6) grounds travel that extracting solution step (4) obtained and step (5) obtain is positioned in the extraction kettle in supercritical extraction instrument, carbon dioxide is utilized to extract as medium, extraction kettle pressure is 40Mpa, extraction temperature is 45 DEG C, separator pressure 12Mpa, separator temperature is 70 DEG C, extracts 2 hours, is extracted liquid;
(7) bamboo salt, hyaluronic acid, conch meal, Oleum menthae and xanthan gum is taken according to proportioning, and mix homogeneously with the filtrate of step (2) gained, the extract of step (6) gained, by mixed liquor pressure be-0.06 ~-0.08Mpa, temperature is concentrated into thick viscous solution under being 40 ~ 45 DEG C of conditions, when the relative density of viscous solution is 45 DEG C 1.15 ~ 1.24;
(8) drying of the viscous solution of step (7) gained is removed moisture until moisture is less than 5%, Crushing of Ultrafine, to mean diameter less than 50 μm, obtains object.
Each component effect of the present invention is resolved as follows:
Resina Liquidambaris is put down, acrid in the mouth, micro-hardship.Return lung meridian, spleen channel, can promoting blood circulation and stopping pain, removing toxic substances, granulation promoting, removing heat from blood, belong to medicine for removing toxic substances and promoting tissue regeneration, with controlling traumatic injury, ulcer sore pain, haematemesis, traumatic hemorrhage etc.Rhizoma Dryopteris Crassirhizomatis is the rhizome of Dryopteridaceae plant dryopteris crassirhizoma, cold nature, bitter in the mouth, returns Liver Channel, stomach warp, anthelmintic, hemostasis, heat-clearing and toxic substances removing, belongs to anthelmintic, and treatment abdominal pain due to worm stagnation, pathopyretic ulcer, mumps swell and ache, metrorrhagia and prevent and treat influenza etc.Spina Gleditsiae is the dry Spina jujubae of leguminous plant Fructus Gleditsia, has detumescence poison holding, evacuation of pus, effect of parasite killing, be usually used in carbuncle from the beginning of or difficulty in discharging of pus; External treatment scabies leprosy.Fructus Cnidii is warm in nature, bitter in the mouth, and energy warming the kidney to invigorate YANG, dampness, dispels the wind, parasite killing.For sexual impotence, cold womb, cold-damp leukorrhagia, arthralgia chiefly caused by damp pathogen lumbago; External treatment vulval eczema, married woman's pudendal pruritus, trichomonal vaginitis.Herba Epimeredis Indicae feeble QI, lightly seasoned micro-hardship, dispels the wind, dehumidifying, removing toxic substances, energy pain relieving, strengthening bone and muscle, and pathogenic wind expelling dispels the heat, detoxification skin ulcer, and except bones and muscles pain, the people that suffers from a deficiency of the kidney gets its infusing drugs in wine drink.Wind-damp dispelling, strengthening bone and muscle, crow palpus, improving eyesight, washes hemorrhoid, washes infantile malnutrition, goes to swell.Periostracum Cicadae energy dispelling wind-heat, rash sore-throat relieving, removing nebula to improve visual acuity, to expelling wind and relieving convulsion.Radix aconiti gymnandri is the dry aerial parts of labiate lycopus lucidus or hair leaf lycopus lucidus, gather in summer, Qiu Liangji, extract aerial parts, cutting is dried, it is warm in nature, bitter in the mouth, pungent, there is effect of promoting blood circulation to restore menstrual flow, inducing diuresis to remove edema, the diseases such as menoxenia, amenorrhea, dysmenorrhea, edema, postnatal blood stasis stomachache can be treated.Resina Toxicodendri acrid in the mouth, warm in nature; Poisonous, return liver, spleen channel; Energy removing blood stasis with potent drugs blood, removing food stagnancy, parasite killing, for women's amenorrhea, blood stasis lump in the abdomen, abdominal pain due to worm stagnation.Folium Mori gas is light, cold in nature, sweet in the mouth, hardship, has effect of dispelling wind and heat pathogens, clearing away lung-heat and moistening for dryness, liver heat removing and eyesight improving, can treat anemopyretic cold, lung-heat type cough, dizziness headache, the disease that conjunctival congestion is dim-sighted.RADIX PEUCEDANI has spasmolytic of eliminating the phlegm, antiplatelet aggregation and antiinflammatory action, and the metabolism and growth effect of anticancer.Radix Ophiopogonis sweet in the mouth, micro-hardship, be slightly cold, lung moistening clear away heart-fire, purge heat promote the production of body fluid, reduce phlegm preventing or arresting vomiting.Radix Oryzae Glutinosae sweet in the mouth, property is put down, yin nourishing, hidroschesis, stomach invigorating, for spontaneous perspiration, night sweat, hepatitis, chyluria.Fructus Momordicae charantiae bitter cold is nontoxic, falls pathogenic heat, separates tired, and clear away heart-fire improving eyesight, and QI invigorating tonifying YANG, has spleen benefiting and stimulating the appetite, and heat clearing away is driven away summer heat, improving eyesight dysentery relieving, the effect of removing pathogenic heat from blood and toxic substance from the body.Herba Portulacae energy heat-clearing and toxic substances removing, loose blood detumescence, controls hematodiarrhoea pus and blood, pyretic stranguria, stranguria with blood, leukorrhagia, carbuncle malignant boil, erysipelas, trace scrofula, for damp and hot caused diarrhoea, dysentery, often join Rhizoma Coptidis, the Radix Aucklandiae, for oral administration or smash juice external application, control carbuncle, also for having blood in stool, metrorrhagia, have anastalsis.Radix Inulae has invigorating the spleen and regulating the stomach, promoting the flow of QI for relieving the stagnancy, effect that pain relieving is antiabortive, and for the breast side of body, abdominal distention, vomiting dysentery, the breast side of body is dampened, and feels a pain in the chest when breathing and has a pain, frequent fetal movement.Cortex Moutan is the dry root bark of ranunculaceae peony, and bitter, pungent, be slightly cold, GUIXIN, liver, kidney channel, have the effects such as clearing away heat and cooling blood, activating blood circulation to dissipate blood stasis, reducing the asthenic fever.Radix Sophorae Flavescentis is used for hematodiarrhoea, has blood in stool, jaundice urine retention, leucorrhea with red and white discharge, swelling of the vulva pudendal pruritus, eczema, eczema, skin pruritus, scabies leprosy, external treatment trichomonal vaginitis.Rhizoma Phragmitis can be used for calentura excessive thirst, gastropyretic vomiting, cough due to lung-heat, lung abscess vomiting pus, the puckery pain of pyretic stranguria.Herba Astragali Melilotoidis (Herba Astragali Sinici) has dispelling pathogenic wind for improving eyesight, invigorating the spleen and benefiting QI, the effect of removing toxic substances pain relieving.Phellodendron bark bitter in the mouth, cold in nature, return kidney, urinary bladder channel, can heat clearing and damp drying, pathogenic fire purging is except steaming, and detoxification sore treatment, for damp-heat dysentery, jaundice, leukorrhagia, pyretic stranguria, beriberi, flaccidity { is warded off }, hectic fever due to YIN-deficiency consumptive fever, night sweat, seminal emission, sore swollen toxin, eczema pruritus.Rhizoma Kaempferiae energy warming middle-JIAO for eliminating dampness, promoting the circulation of QI to relieve pain.Cure mainly acute gastroenteritis, dyspepsia, cold syndrome of the stomach pain, toothache, rheumatic arthritis, traumatic injury.Herba Houttuyniae acrid in the mouth, cold, return lung meridian, energy heat-clearing and toxic substances removing, detumescence treat skin ulcer, promoting urination to remove dampness, clearing away heat to cure dysentery, invigorating the stomach and promoting digestion, with controlling excess-heat, pyretic toxicity, damp, disease heat is the lung abscess, sore swollen toxin, hemorrhoidal hemorrhage, retention of heat in the spleen and stomach etc. suffered from, modern pharmacology experiment shows, this product has the effect such as antibacterial, antiviral, raising immunity of organisms, diuresis.Herba Plantaginis is the drying of Plantaginaceae plant Herba Plantaginis or Plantago depressa Willd or fresh herb, and sweet in the mouth is cold in nature, heat clearing away, and diuresis, eliminates the phlegm, removing heat from blood, removing toxic substances, for edema oliguria, and the puckery pain of pyretic stranguria, heat-damp in summer dysentery, phlegm-heat cough, hematemesis and epistaxis, carbuncle sore tumefacting virus.Bulbus Allii can separate hundred poison, and in Bulbus Allii, sulfur-containing compound has strong antibacterial and anti-inflammation functions, and all having suppression and killing action to multiple coccus, bacillus, fungus and virus etc., is the one that in the natural plants of current discovery, antibacterial action is the strongest.Bamboo salt can bactericidal.Hyaluronic acid can improve skin-nourishing metabolism, and make that skin is tender, smooth, wrinkle removing, increase elasticity, prevent aging, be again good Percutaneous absorption enhancer while moisturizing.Not only containing a large amount of calcium in conch meal, but also containing necessary trace element in poultry body: phosphorus, manganese, zinc, copper, ferrum, potassium, magnesium etc.Oleum menthae light weight a surname is loose, has dispelling wind and heat pathogens, has the merit declaring malicious rash, can be used for measles without adequate eruption, rubella pruritus.Add xanthan gum and can improve the stability of powder of the present invention in water, reduce the pollution of powder of the present invention to water body environment.
In preparation method, the effect of extracting after Resina Liquidambaris, Rhizoma Dryopteris Crassirhizomatis and Spina Gleditsiae being pulverized is conducive to the effective ingredient in Resina Liquidambaris, Rhizoma Dryopteris Crassirhizomatis and Spina Gleditsiae fully to extract; By purified to Fructus Cnidii, Herba Epimeredis Indicae, Folium Mori, RADIX PEUCEDANI, Radix Ophiopogonis, Radix Oryzae Glutinosae, Fructus Momordicae charantiae, Rhizoma Phragmitis, Herba Astragali Melilotoidis (Herba Astragali Sinici), Herba Houttuyniae, Herba Plantaginis and Bulbus Allii water soaking a period of time, medical material deliquescing, cell expansion, effective ingredient is easily fried, and medical material contains starch, protein, after soaking, prevent when decocting, the starch gelatinization on medical material surface, protein coagulating, the capillary channel on blocking medical material surface, makes the moisture when decocting enter not go, effective ingredient is not easily fried, affects curative effect of medication; Decoction can change the irritation effect of medicine, relatively mildly acts on fragrant fish, promotes that fragrant fish is to the absorption of medicine; By Periostracum Cicadae, Radix aconiti gymnandri, Resina Toxicodendri, Herba Portulacae, Radix Inulae, Cortex Moutan, Radix Sophorae Flavescentis, phellodendron bark with Rhizoma Kaempferiae grinding can make the starch in medical material, protein separates out more fully at subsequent step; Supercritical extraction step can retain the effective ingredient of each component in the present invention to greatest extent.Crushing of Ultrafine is the emission and absorption being conducive to effective ingredient to the object of mean diameter less than 50 μm.
The powder of control fragrant fish hemorrhagic disease of the present invention is the etiopathogenesis according to hemorrhagic disease, the suitable component of selection, and is organically combined, and has significant cooperative synergism effect, plays the function of each component to greatest extent.The component of the powder of control fragrant fish hemorrhagic disease of the present invention is environmental protection raw material, nontoxic to environment, be conducive to the sustainable health development of fragrant fish cultivation industry, the healthy of people can not be affected after edible fragrant fish of having cured, and powder of the present invention is good to the curative effect of fragrant fish hemorrhagic disease, cure rate is high, make the survival rate of ill fragrant fish to more than 90%, after medication 1-3 days, fragrant fish veutro petechial hemorrhage phenomenon is inhibited, veutro petechial hemorrhage area progressively reduces, and fragrant fish starts progressively to recover to ingest simultaneously, and ingestion frequency improves.In addition, the present invention uses safer, little to fragrant fish damage; after using the powder for the treatment of fragrant fish hemorrhagic disease of the present invention; fragrant fish Health restoration is fast, medication 3-6 days, and fragrant fish eyeball blood stasis protrusion phenomenon disappears; the gill cover recovers normal; veutro petechial hemorrhage phenomenon disappears, and the red and swollen phenomenon of anus disappears, and fragrant fish recovers normal activity completely; idle fund is strong and vigorous, ingests completely normal.In addition, the powder of control fragrant fish hemorrhagic disease of the present invention effectively can also prevent the generation of fragrant fish hemorrhagic disease.
Compared with prior art, the invention has the beneficial effects as follows:
(1) in each component of the present invention, Resina Liquidambaris is monarch drug, and Resina Liquidambaris is put down, acrid in the mouth, micro-hardship.Return lung meridian, spleen channel, can promoting blood circulation and stopping pain, removing toxic substances, granulation promoting, removing heat from blood, belong to medicine for removing toxic substances and promoting tissue regeneration, with controlling traumatic injury, ulcer sore pain, haematemesis, traumatic hemorrhage etc.
Rhizoma Dryopteris Crassirhizomatis is the rhizome of Dryopteridaceae plant dryopteris crassirhizoma, cold nature, bitter in the mouth, returns Liver Channel, stomach warp, anthelmintic, hemostasis, heat-clearing and toxic substances removing, belongs to anthelmintic, and treatment abdominal pain due to worm stagnation, pathopyretic ulcer, mumps swell and ache, metrorrhagia and prevent and treat influenza etc.Spina Gleditsiae is the dry Spina jujubae of leguminous plant Fructus Gleditsia, has detumescence poison holding, evacuation of pus, effect of parasite killing, be usually used in carbuncle from the beginning of or difficulty in discharging of pus; External treatment scabies leprosy.Fructus Cnidii is warm in nature, bitter in the mouth, and energy warming the kidney to invigorate YANG, dampness, dispels the wind, parasite killing.For sexual impotence, cold womb, cold-damp leukorrhagia, arthralgia chiefly caused by damp pathogen lumbago; External treatment vulval eczema, married woman's pudendal pruritus, trichomonal vaginitis.Herba Epimeredis Indicae feeble QI, lightly seasoned micro-hardship, dispels the wind, dehumidifying, detoxifies, energy pain relieving, strengthening bone and muscle, and pathogenic wind expelling dispels the heat, detoxification skin ulcer, and except bones and muscles pain, the people that suffers from a deficiency of the kidney gets its infusing drugs in wine drink, wind-damp dispelling, strengthening bone and muscle, and crow palpus, improving eyesight, washes hemorrhoid, washes infantile malnutrition, goes to swell.Rhizoma Dryopteris Crassirhizomatis, Spina Gleditsiae, Fructus Cnidii and Herba Epimeredis Indicae are ministerial drug.
Periostracum Cicadae, Radix aconiti gymnandri, Resina Toxicodendri, Folium Mori, RADIX PEUCEDANI, Radix Ophiopogonis, Radix Oryzae Glutinosae, Fructus Momordicae charantiae, Herba Portulacae, Radix Inulae, bamboo salt, hyaluronic acid, conch meal, Oleum menthae and xanthan gum are adjuvant drug.Periostracum Cicadae energy dispelling wind-heat, rash sore-throat relieving, removing nebula to improve visual acuity, to expelling wind and relieving convulsion.Radix aconiti gymnandri is the dry aerial parts of labiate lycopus lucidus or hair leaf lycopus lucidus, gather in summer, Qiu Liangji, extract aerial parts, cutting is dried, it is warm in nature, bitter in the mouth, pungent, there is effect of promoting blood circulation to restore menstrual flow, inducing diuresis to remove edema, the diseases such as menoxenia, amenorrhea, dysmenorrhea, edema, postnatal blood stasis stomachache can be treated.Resina Toxicodendri acrid in the mouth, warm in nature; Poisonous, return liver, spleen channel; Energy removing blood stasis with potent drugs blood, removing food stagnancy, parasite killing, for women's amenorrhea, blood stasis lump in the abdomen, abdominal pain due to worm stagnation.Folium Mori gas is light, cold in nature, sweet in the mouth, hardship, has effect of dispelling wind and heat pathogens, clearing away lung-heat and moistening for dryness, liver heat removing and eyesight improving, can treat anemopyretic cold, lung-heat type cough, dizziness headache, the disease that conjunctival congestion is dim-sighted.RADIX PEUCEDANI has spasmolytic of eliminating the phlegm, antiplatelet aggregation and antiinflammatory action, and the metabolism and growth effect of anticancer.Radix Ophiopogonis sweet in the mouth, micro-hardship, be slightly cold, lung moistening clear away heart-fire, purge heat promote the production of body fluid, reduce phlegm preventing or arresting vomiting.Radix Oryzae Glutinosae sweet in the mouth, property is put down, yin nourishing, hidroschesis, stomach invigorating, for spontaneous perspiration, night sweat, hepatitis, chyluria.Fructus Momordicae charantiae bitter cold is nontoxic, falls pathogenic heat, separates tired, and clear away heart-fire improving eyesight, and QI invigorating tonifying YANG, has spleen benefiting and stimulating the appetite, and heat clearing away is driven away summer heat, improving eyesight dysentery relieving, the effect of removing pathogenic heat from blood and toxic substance from the body.Herba Portulacae energy heat-clearing and toxic substances removing, loose blood detumescence, controls hematodiarrhoea pus and blood, pyretic stranguria, stranguria with blood, leukorrhagia, carbuncle malignant boil, erysipelas, trace scrofula, for damp and hot caused diarrhoea, dysentery, often join Rhizoma Coptidis, the Radix Aucklandiae, for oral administration or smash juice external application, control carbuncle, also for having blood in stool, metrorrhagia, have anastalsis.Radix Inulae has invigorating the spleen and regulating the stomach, promoting the flow of QI for relieving the stagnancy, effect that pain relieving is antiabortive, and for the breast side of body, abdominal distention, vomiting dysentery, the breast side of body is dampened, and feels a pain in the chest when breathing and has a pain, frequent fetal movement.Bamboo salt can bactericidal.Hyaluronic acid can improve skin-nourishing metabolism, and make that skin is tender, smooth, wrinkle removing, increase elasticity, prevent aging, be again good Percutaneous absorption enhancer while moisturizing.Not only containing a large amount of calcium in conch meal, but also containing necessary trace element in poultry body: phosphorus, manganese, zinc, copper, ferrum, potassium, magnesium etc.Oleum menthae light weight a surname is loose, has dispelling wind and heat pathogens, has the merit declaring malicious rash, can be used for measles without adequate eruption, rubella pruritus.Add xanthan gum and can improve the stability of powder of the present invention in water, reduce the pollution of powder of the present invention to water body environment.
Cortex Moutan, Radix Sophorae Flavescentis, Rhizoma Phragmitis, Herba Astragali Melilotoidis (Herba Astragali Sinici), phellodendron bark, Rhizoma Kaempferiae, Herba Houttuyniae, Herba Plantaginis and Bulbus Allii are for making medicine.Cortex Moutan is the dry root bark of ranunculaceae peony, and bitter, pungent, be slightly cold, GUIXIN, liver, kidney channel, have the effects such as clearing away heat and cooling blood, activating blood circulation to dissipate blood stasis, reducing the asthenic fever.Radix Sophorae Flavescentis is used for hematodiarrhoea, has blood in stool, jaundice urine retention, leucorrhea with red and white discharge, swelling of the vulva pudendal pruritus, eczema, eczema, skin pruritus, scabies leprosy, external treatment trichomonal vaginitis.Rhizoma Phragmitis can be used for calentura excessive thirst, gastropyretic vomiting, cough due to lung-heat, lung abscess vomiting pus, the puckery pain of pyretic stranguria.Herba Astragali Melilotoidis (Herba Astragali Sinici) has dispelling pathogenic wind for improving eyesight, invigorating the spleen and benefiting QI, the effect of removing toxic substances pain relieving.Phellodendron bark bitter in the mouth, cold in nature, return kidney, urinary bladder channel, can heat clearing and damp drying, pathogenic fire purging is except steaming, and detoxification sore treatment, for damp-heat dysentery, jaundice, leukorrhagia, pyretic stranguria, beriberi, flaccidity { is warded off }, hectic fever due to YIN-deficiency consumptive fever, night sweat, seminal emission, sore swollen toxin, eczema pruritus.Rhizoma Kaempferiae energy warming middle-JIAO for eliminating dampness, promoting the circulation of QI to relieve pain.Cure mainly acute gastroenteritis, dyspepsia, cold syndrome of the stomach pain, toothache, rheumatic arthritis, traumatic injury.Herba Houttuyniae acrid in the mouth, cold, return lung meridian, energy heat-clearing and toxic substances removing, detumescence treat skin ulcer, promoting urination to remove dampness, clearing away heat to cure dysentery, invigorating the stomach and promoting digestion, with controlling excess-heat, pyretic toxicity, damp, disease heat is the lung abscess, sore swollen toxin, hemorrhoidal hemorrhage, retention of heat in the spleen and stomach etc. suffered from, modern pharmacology experiment shows, this product has the effect such as antibacterial, antiviral, raising immunity of organisms, diuresis.Herba Plantaginis is the drying of Plantaginaceae plant Herba Plantaginis or Plantago depressa Willd or fresh herb, and sweet in the mouth is cold in nature, heat clearing away, and diuresis, eliminates the phlegm, removing heat from blood, removing toxic substances, for edema oliguria, and the puckery pain of pyretic stranguria, heat-damp in summer dysentery, phlegm-heat cough, hematemesis and epistaxis, carbuncle sore tumefacting virus.Bulbus Allii can separate hundred poison, and in Bulbus Allii, sulfur-containing compound has strong antibacterial and anti-inflammation functions, and all having suppression and killing action to multiple coccus, bacillus, fungus and virus etc., is the one that in the natural plants of current discovery, antibacterial action is the strongest.
(2) powder of control fragrant fish hemorrhagic disease of the present invention, is the Chinese herbal medicine selected according to the etiopathogenesis of hemorrhagic disease, and is organically combined, have significant cooperative synergism effect, played the function of each component to greatest extent.
(3) pathogen of powder to fragrant fish hemorrhagic disease of control fragrant fish hemorrhagic disease of the present invention has good inhibition.
(4) component of the powder of control fragrant fish hemorrhagic disease of the present invention is environmental protection raw material, nontoxic to environment, without chemical drugs or antibiotic, the healthy of people can not be affected after edible fragrant fish of having cured, and the powder of control fragrant fish hemorrhagic disease of the present invention is very little to fragrant fish damage, after using the powder of control fragrant fish hemorrhagic disease of the present invention, fragrant fish Health restoration is fast.In addition, the powder of control fragrant fish hemorrhagic disease of the present invention is easy to use, will not pull rear medicine-feeding out by sick fish, decrease the injury to sick fish in operating process.
(5), in preparation method, the effect of extracting after Resina Liquidambaris, Rhizoma Dryopteris Crassirhizomatis and Spina Gleditsiae being pulverized is conducive to the effective ingredient in Resina Liquidambaris, Rhizoma Dryopteris Crassirhizomatis and Spina Gleditsiae fully to extract; By purified to Fructus Cnidii, Herba Epimeredis Indicae, Folium Mori, RADIX PEUCEDANI, Radix Ophiopogonis, Radix Oryzae Glutinosae, Fructus Momordicae charantiae, Rhizoma Phragmitis, Herba Astragali Melilotoidis (Herba Astragali Sinici), Herba Houttuyniae, Herba Plantaginis and Bulbus Allii water soaking a period of time, medical material deliquescing, cell expansion, effective ingredient is easily fried, and medical material contains starch, protein, after soaking, prevent when decocting, the starch gelatinization on medical material surface, protein coagulating, the capillary channel on blocking medical material surface, makes the moisture when decocting enter not go, effective ingredient is not easily fried, affects curative effect of medication; Decoction can change the irritation effect of medicine, relatively mildly acts on fragrant fish, promotes that fragrant fish is to the absorption of medicine; By Periostracum Cicadae, Radix aconiti gymnandri, Resina Toxicodendri, Herba Portulacae, Radix Inulae, Cortex Moutan, Radix Sophorae Flavescentis, phellodendron bark with Rhizoma Kaempferiae grinding can make the starch in medical material, protein separates out more fully at subsequent step; Supercritical extraction step can retain the effective ingredient of each component in the present invention to greatest extent.Crushing of Ultrafine is the emission and absorption being conducive to effective ingredient to the object of mean diameter less than 50 μm.
Detailed description of the invention
Following embodiment is convenient to understand the present invention better, but does not limit the present invention.Experimental technique in following embodiment, if no special instructions, is conventional method.
Embodiment 1
A kind of powder preventing and treating fragrant fish hemorrhagic disease, be made up of each component of following masses number: Resina Liquidambaris 42 parts, Rhizoma Dryopteris Crassirhizomatis 34 parts, Spina Gleditsiae 34 parts, Fructus Cnidii 32 parts, Herba Epimeredis Indicae 33 parts, Periostracum Cicadae 15 parts, Radix aconiti gymnandri 30 parts, Resina Toxicodendri 30 parts, 27 parts, Folium Mori, RADIX PEUCEDANI 26 parts, Radix Ophiopogonis 28 parts, Radix Oryzae Glutinosae 28 parts, 28 parts, Fructus Momordicae charantiae, Herba Portulacae 27 parts, Radix Inulae 26 parts, Cortex Moutan 26 parts, Radix Sophorae Flavescentis 25 parts, Rhizoma Phragmitis 25 parts, Herba Astragali Melilotoidis (Herba Astragali Sinici) 21 parts, phellodendron bark 20 parts, Rhizoma Kaempferiae 20 parts, Herba Houttuyniae 18 parts, Herba Plantaginis 17 parts, 14 parts, Bulbus Allii, bamboo salt 16 parts, hyaluronic acid 5 parts, conch meal 9 parts, Oleum menthae 13 parts, xanthan gum 5 parts.
The preparation method of the powder of above-mentioned control fragrant fish hemorrhagic disease comprises the following steps:
(1) take Resina Liquidambaris, Rhizoma Dryopteris Crassirhizomatis and Spina Gleditsiae according to proportioning, pulverize putting into pulverizer after Resina Liquidambaris, Rhizoma Dryopteris Crassirhizomatis and Spina Gleditsiae mix homogeneously and cross 100 mesh sieves, obtaining comminuted powder;
(2) by mass concentration be 50% ethanol add in Chinese medicine extracting tank, ethanol consumption is 10 times of the comminuted powder weight of step (1) gained, open and stir, the comminuted powder of step (1) gained is added in Chinese medicine extracting tank, temperature of charge in Chinese medicine extracting tank is warming up to 75-80 DEG C of constant temperature and extracts 30-40min, 100 orders cross leaching filtrate, and filtering residue returns in Chinese medicine extracting tank and repeats to extract once, 100 orders cross leaching filtrate, merge twice gained filtrate;
(3) Fructus Cnidii, Herba Epimeredis Indicae, Folium Mori, RADIX PEUCEDANI, Radix Ophiopogonis, Radix Oryzae Glutinosae, Fructus Momordicae charantiae, Rhizoma Phragmitis, Herba Astragali Melilotoidis (Herba Astragali Sinici), Herba Houttuyniae, Herba Plantaginis and Bulbus Allii is taken according to proportioning, gross weight is designated as 1 part, add 8 parts of purified water, 20-30 DEG C is soaked 6-9h, obtains soak;
(4) boil 2h after the soak that step (3) obtains being heated to boiling, be separated and take out fried liquid, continue the purified water adding 4 parts in medical material, continue to boil 1h after being heated to boiling, merge twice fried liquid and be extracting solution;
(5) take Periostracum Cicadae, Radix aconiti gymnandri, Resina Toxicodendri, Herba Portulacae, Radix Inulae, Cortex Moutan, Radix Sophorae Flavescentis, phellodendron bark and Rhizoma Kaempferiae respectively according to proportioning, load ball mill grinding 2h, cross 80 mesh sieves, obtain grounds travel;
(6) grounds travel that extracting solution step (4) obtained and step (5) obtain is positioned in the extraction kettle in supercritical extraction instrument, carbon dioxide is utilized to extract as medium, extraction kettle pressure is 40Mpa, extraction temperature is 45 DEG C, separator pressure 12Mpa, separator temperature is 70 DEG C, extracts 2 hours, is extracted liquid;
(7) bamboo salt, hyaluronic acid, conch meal, Oleum menthae and xanthan gum is taken according to proportioning, and mix homogeneously with the filtrate of step (2) gained, the extract of step (6) gained, by mixed liquor pressure be-0.06 ~-0.08Mpa, temperature is concentrated into thick viscous solution under being 40 ~ 45 DEG C of conditions, when the relative density of viscous solution is 45 DEG C 1.15 ~ 1.24;
(8) drying of the viscous solution of step (7) gained is removed moisture until moisture is less than 5%, Crushing of Ultrafine, to mean diameter less than 50 μm, obtains object.
Embodiment 2
A kind of powder preventing and treating fragrant fish hemorrhagic disease, be made up of each component of following masses number: Resina Liquidambaris 44 parts, Rhizoma Dryopteris Crassirhizomatis 36 parts, Spina Gleditsiae 36 parts, Fructus Cnidii 35 parts, Herba Epimeredis Indicae 32 parts, Periostracum Cicadae 13 parts, Radix aconiti gymnandri 28 parts, Resina Toxicodendri 28 parts, 30 parts, Folium Mori, RADIX PEUCEDANI 29 parts, Radix Ophiopogonis 25 parts, Radix Oryzae Glutinosae 25 parts, 25 parts, Fructus Momordicae charantiae, Herba Portulacae 24 parts, Radix Inulae 23 parts, Cortex Moutan 22 parts, Radix Sophorae Flavescentis 21 parts, Rhizoma Phragmitis 21 parts, Herba Astragali Melilotoidis (Herba Astragali Sinici) 18 parts, phellodendron bark 21 parts, Rhizoma Kaempferiae 17 parts, Herba Houttuyniae 15 parts, Herba Plantaginis 14 parts, 15 parts, Bulbus Allii, bamboo salt 18 parts, hyaluronic acid 4 parts, conch meal 8 parts, Oleum menthae 12 parts, xanthan gum 5 parts.
The preparation method of the powder of the control fragrant fish hemorrhagic disease of the present embodiment is with embodiment 1.
Embodiment 3
A kind of powder preventing and treating fragrant fish hemorrhagic disease, Resina Liquidambaris 39 parts is formed by each component of following masses number, Rhizoma Dryopteris Crassirhizomatis 30 parts, Spina Gleditsiae 33 parts, Fructus Cnidii 32 parts, Herba Epimeredis Indicae 30 parts, Periostracum Cicadae 11 parts, Radix aconiti gymnandri 25 parts, Resina Toxicodendri 25 parts, 25 parts, Folium Mori, RADIX PEUCEDANI 24 parts, Radix Ophiopogonis 23 parts, Radix Oryzae Glutinosae 23 parts, 21 parts, Fructus Momordicae charantiae, Herba Portulacae 22 parts, Radix Inulae 20 parts, Cortex Moutan 20 parts, Radix Sophorae Flavescentis 20 parts, Rhizoma Phragmitis 18 parts, Herba Astragali Melilotoidis (Herba Astragali Sinici) 17 parts, phellodendron bark 18 parts, Rhizoma Kaempferiae 16 parts, Herba Houttuyniae 14 parts, Herba Plantaginis 13 parts, 12 parts, Bulbus Allii, bamboo salt 15 parts, hyaluronic acid 4 parts, conch meal 7 parts, Oleum menthae 9 parts, xanthan gum 4 parts.
The preparation method of the powder of the control fragrant fish hemorrhagic disease of the present embodiment is with embodiment 1.
Embodiment 4
A kind of powder preventing and treating fragrant fish hemorrhagic disease, be made up of each component of following masses number: Resina Liquidambaris 37 parts, Rhizoma Dryopteris Crassirhizomatis 28 parts, Spina Gleditsiae 31 parts, Fructus Cnidii 30 parts, Herba Epimeredis Indicae 29 parts, Periostracum Cicadae 9 parts, Radix aconiti gymnandri 23 parts, Resina Toxicodendri 23 parts, 22 parts, Folium Mori, RADIX PEUCEDANI 21 parts, Radix Ophiopogonis 20 parts, Radix Oryzae Glutinosae 20 parts, 18 parts, Fructus Momordicae charantiae, Herba Portulacae 19 parts, Radix Inulae 17 parts, Cortex Moutan 16 parts, Radix Sophorae Flavescentis 16 parts, Rhizoma Phragmitis 14 parts, Herba Astragali Melilotoidis (Herba Astragali Sinici) 14 parts, phellodendron bark 13 parts, Rhizoma Kaempferiae 12 parts, Herba Houttuyniae 11 parts, Herba Plantaginis 12 parts, 11 parts, Bulbus Allii, bamboo salt 13 parts, hyaluronic acid 3 parts, conch meal 6 parts, Oleum menthae 9 parts, xanthan gum 3 parts.
The preparation method of the powder of the control fragrant fish hemorrhagic disease of the present embodiment is with embodiment 1.
Embodiment 5
A kind of powder preventing and treating fragrant fish hemorrhagic disease, be made up of each component of following masses number: Resina Liquidambaris 40 parts, Rhizoma Dryopteris Crassirhizomatis 30 parts, Spina Gleditsiae 28 parts, Fructus Cnidii 27 parts, Herba Epimeredis Indicae 27 parts, Periostracum Cicadae 9 parts, Radix aconiti gymnandri 24 parts, Resina Toxicodendri 23 parts, 22 parts, Folium Mori, RADIX PEUCEDANI 21 parts, Radix Ophiopogonis 20 parts, Radix Oryzae Glutinosae 20 parts, 18 parts, Fructus Momordicae charantiae, Herba Portulacae 19 parts, Radix Inulae 17 parts, Cortex Moutan 16 parts, Radix Sophorae Flavescentis 16 parts, Rhizoma Phragmitis 15 parts, Herba Astragali Melilotoidis (Herba Astragali Sinici) 14 parts, phellodendron bark 15 parts, Rhizoma Kaempferiae 15 parts, Herba Houttuyniae 12 parts, Herba Plantaginis 10 parts, 7 parts, Bulbus Allii, bamboo salt 10 parts, hyaluronic acid 2 parts, conch meal 5 parts, Oleum menthae 6 parts, xanthan gum 3 parts.
The preparation method of the powder of the control fragrant fish hemorrhagic disease of the present embodiment is with embodiment 1.
Embodiment 6
A kind of powder preventing and treating fragrant fish hemorrhagic disease, be made up of each component of following masses number: Resina Liquidambaris 40 parts, Rhizoma Dryopteris Crassirhizomatis 32 parts, Spina Gleditsiae 32 parts, Fructus Cnidii 31 parts, Herba Epimeredis Indicae 30 parts, Periostracum Cicadae 12 parts, Radix aconiti gymnandri 27 parts, Resina Toxicodendri 27 parts, 26 parts, Folium Mori, RADIX PEUCEDANI 25 parts, Radix Ophiopogonis 24 parts, Radix Oryzae Glutinosae 24 parts, 23 parts, Fructus Momordicae charantiae, Herba Portulacae 23 parts, Radix Inulae 22 parts, Cortex Moutan 21 parts, Radix Sophorae Flavescentis 20 parts, Rhizoma Phragmitis 20 parts, Herba Astragali Melilotoidis (Herba Astragali Sinici) 18 parts, phellodendron bark 17 parts, Rhizoma Kaempferiae 16 parts, Herba Houttuyniae 15 parts, Herba Plantaginis 13 parts, 11 parts, Bulbus Allii, bamboo salt 14 parts, hyaluronic acid 4 parts, conch meal 7 parts, Oleum menthae 10 parts, xanthan gum 4 parts.
The preparation method of the powder of the control fragrant fish hemorrhagic disease of the present embodiment is with embodiment 1.
Experimental result
Contrast experiment 1
Test site is selected in fishing ground, Qingdao, in order to verify therapeutic effect of the present invention, is testing the fragrant fish suffering from hemorrhagic disease:
The process of matched group is as follows: to splash pond, disease fish place all over pond with the erythromycin of 0.4-1ppm, every day 1-2 time, use continuously until sick fish is fully recovered.
The process of experiment A group is as follows: the powder evenly throwing in the control fragrant fish hemorrhagic disease of the 50g embodiment of the present invention 1 in water body per ton, once a day, until the recovery from illness of sick fish.
The process of experiment B group is as follows: the powder evenly throwing in the control fragrant fish hemorrhagic disease of the 50g embodiment of the present invention 2 in water body per ton, once a day, until the recovery from illness of sick fish.
The process of experiment C group is as follows: the powder evenly throwing in the control fragrant fish hemorrhagic disease of the 50g embodiment of the present invention 3 in water body per ton, once a day, until the recovery from illness of sick fish.
The process of experiment D group is as follows: the powder evenly throwing in the control fragrant fish hemorrhagic disease of the 50g embodiment of the present invention 4 in water body per ton, once a day, until the recovery from illness of sick fish.
The process of experiment E group is as follows: the powder evenly throwing in the control fragrant fish hemorrhagic disease of the 50g embodiment of the present invention 5 in water body per ton, once a day, until the recovery from illness of sick fish.
The process of experiment F group is as follows: the powder evenly throwing in the control fragrant fish hemorrhagic disease of the 50g embodiment of the present invention 6 in water body per ton, once a day, until the recovery from illness of sick fish.
Experimental result is in table 1:
The powder therapeutic effect of table 1 control of the present invention fragrant fish hemorrhagic disease
Experimental result shows: the powder of control fragrant fish hemorrhagic disease of the present invention is the etiopathogenesis according to hemorrhagic disease, the suitable component of selection, and is organically combined, and has significant cooperative synergism effect, plays the function of each component to greatest extent.The component of the powder of control fragrant fish hemorrhagic disease of the present invention is environmental protection raw material, nontoxic to environment, be conducive to the sustainable health development of fragrant fish cultivation industry, the healthy of people can not be affected after edible fragrant fish of having cured, and powder of the present invention is good to the curative effect of fragrant fish hemorrhagic disease, cure rate is high, make the survival rate of ill fragrant fish to more than 90%, after medication 1-3 days, fragrant fish veutro petechial hemorrhage phenomenon is inhibited, veutro petechial hemorrhage area progressively reduces, and fragrant fish starts progressively to recover to ingest simultaneously, and ingestion frequency improves.In addition, the present invention uses safer, little to fragrant fish damage; after using the powder for the treatment of fragrant fish hemorrhagic disease of the present invention; fragrant fish Health restoration is fast, medication 3-6 days, and fragrant fish eyeball blood stasis protrusion phenomenon disappears; the gill cover recovers normal; veutro petechial hemorrhage phenomenon disappears, and the red and swollen phenomenon of anus disappears, and fragrant fish recovers normal activity completely; idle fund is strong and vigorous, ingests completely normal.
Contrast experiment 2
Normally to raise group for blank group.Experimental group process is as follows:
Experiment a group: the powder evenly throwing in the control fragrant fish hemorrhagic disease of the 30g embodiment of the present invention 1 in water body per ton, once a day.
Experiment b group: the powder evenly throwing in the control fragrant fish hemorrhagic disease of the 30g embodiment of the present invention 2 in water body per ton, once a day.
Experiment c group: the powder evenly throwing in the control fragrant fish hemorrhagic disease of the 30g embodiment of the present invention 3 in water body per ton, once a day.
Experiment d group: the powder evenly throwing in the control fragrant fish hemorrhagic disease of the 30g embodiment of the present invention 4 in water body per ton, once a day.
Experiment e group: the powder evenly throwing in the control fragrant fish hemorrhagic disease of the 30g embodiment of the present invention 5 in water body per ton, once a day.
Experiment f group: the powder evenly throwing in the control fragrant fish hemorrhagic disease of the 30g embodiment of the present invention 6 in water body per ton, once a day.
When experiment starts, each processed group puts into healthy fragrant fish 10, after raising 20 days, adds the fragrant fish that 1 is suffered from hemorrhagic disease in each processed group by above-mentioned process, observes and records infection state after one week.The results are shown in Table 2:
The effect of the powder prevention hemorrhagic disease of table 2 control of the present invention fragrant fish hemorrhagic disease
From table 2, the powder of control fragrant fish hemorrhagic disease of the present invention effectively can reduce the incidence rate of fragrant fish hemorrhagic disease, can improve the immunity of fragrant fish, has good preventive effect to hemorrhagic disease.
Bacteriostatic test checks
With erythromycin as matched group, the powder of the control fragrant fish hemorrhagic disease of embodiment of the present invention 1-embodiment 6 is that experimental group carries out antibacterial inspection.
Culture medium: LB culture medium.
Strain is: streptococcus.
Matched group antibacterial liquid is prepared: be dissolved in by erythromycin in sterile deionized water, concentration is 1ppm.
Experimental group antibacterial liquid is prepared: be dissolved in respectively in sterile deionized water by the powder of the control fragrant fish hemorrhagic disease of embodiment of the present invention 1-embodiment 6, liquor strength being diluted to concentration is 1ppm.
Observe and record experimental result:
Represent with "-" without inhibition zone;
Antibacterial circle diameter < 10mm is slightly antibacterial, represents with "+";
Antibacterial circle diameter 10 ~ 14mm is that moderate is antibacterial, represents with " ++ ";
Antibacterial circle diameter > 14mm is highly antibacterial, represents with " +++ "; To streptococcic fungistatic effect in table 3:
The bactericidal and bacteriostatic effect of the powder of table 3 control of the present invention fragrant fish hemorrhagic disease
From table 3, the pathogen streptococcus of powder to hemorrhagic disease of control fragrant fish hemorrhagic disease of the present invention has good bactericidal and bacteriostatic effect.
The above is only the preferred embodiment of the present invention, is noted that for those skilled in the art, and under the premise without departing from the principles of the invention, can also make some improvement, these improvement should be considered as protection scope of the present invention.

Claims (4)

1. prevent and treat the powder of fragrant fish hemorrhagic disease for one kind, it is characterized in that: be made up of each component of following masses number: Resina Liquidambaris 37-44 part, Rhizoma Dryopteris Crassirhizomatis 28-36 part, Spina Gleditsiae 28-36 part, Fructus Cnidii 27-35 part, Herba Epimeredis Indicae 27-33 part, Periostracum Cicadae 9-15 part, Radix aconiti gymnandri 23-30 part, Resina Toxicodendri 23-30 part, Folium Mori 22-30 part, RADIX PEUCEDANI 21-29 part, Radix Ophiopogonis 20-28 part, Radix Oryzae Glutinosae 20-28 part, Fructus Momordicae charantiae 18-28 part, Herba Portulacae 19-27 part, Radix Inulae 17-26 part, Cortex Moutan 16-26 part, Radix Sophorae Flavescentis 16-25 part, Rhizoma Phragmitis 14-25 part, Herba Astragali Melilotoidis (Herba Astragali Sinici) 14-21 part, phellodendron bark 13-21 part, Rhizoma Kaempferiae 12-20 part, Herba Houttuyniae 11-18 part, Herba Plantaginis 10-17 part, Bulbus Allii 7-15 part, bamboo salt 10-18 part, hyaluronic acid 2-5 part, conch meal 5-9 part, Oleum menthae 6-13 part, xanthan gum 3-5 part.
2. the powder of control fragrant fish hemorrhagic disease according to claim 1, it is characterized in that: the powder of described control fragrant fish hemorrhagic disease, be made up of each component of following masses number: Resina Liquidambaris 39-42 part, Rhizoma Dryopteris Crassirhizomatis 30-34 part, Spina Gleditsiae 31-33 part, Fructus Cnidii 30-32 part, Herba Epimeredis Indicae 29-30 part, Periostracum Cicadae 11-13 part, Radix aconiti gymnandri 25-28 part, Resina Toxicodendri 25-28 part, Folium Mori 25-27 part, RADIX PEUCEDANI 24-26 part, Radix Ophiopogonis 23-25 part, Radix Oryzae Glutinosae 23-25 part, Fructus Momordicae charantiae 21-25 part, Herba Portulacae 22-24 part, Radix Inulae 20-23 part, Cortex Moutan 20-22 part, Radix Sophorae Flavescentis 20-21 part, Rhizoma Phragmitis 18-21 part, Herba Astragali Melilotoidis (Herba Astragali Sinici) 17-18 part, phellodendron bark 15-18 part, Rhizoma Kaempferiae 15-17 part, Herba Houttuyniae 14-15 part, Herba Plantaginis 13-14 part, Bulbus Allii 11-12 part, bamboo salt 13-15 part, hyaluronic acid 3-4 part, conch meal 6-8 part, Oleum menthae 9-12 part, xanthan gum 3-5 part.
3. the powder of control fragrant fish hemorrhagic disease according to claim 1, it is characterized in that: the powder of described control fragrant fish hemorrhagic disease, be made up of each component of following masses number: Resina Liquidambaris 40 parts, Rhizoma Dryopteris Crassirhizomatis 32 parts, Spina Gleditsiae 32 parts, Fructus Cnidii 31 parts, Herba Epimeredis Indicae 30 parts, Periostracum Cicadae 12 parts, Radix aconiti gymnandri 27 parts, Resina Toxicodendri 27 parts, 26 parts, Folium Mori, RADIX PEUCEDANI 25 parts, Radix Ophiopogonis 24 parts, Radix Oryzae Glutinosae 24 parts, 23 parts, Fructus Momordicae charantiae, Herba Portulacae 23 parts, Radix Inulae 22 parts, Cortex Moutan 21 parts, Radix Sophorae Flavescentis 20 parts, Rhizoma Phragmitis 20 parts, Herba Astragali Melilotoidis (Herba Astragali Sinici) 18 parts, phellodendron bark 17 parts, Rhizoma Kaempferiae 16 parts, Herba Houttuyniae 15 parts, Herba Plantaginis 13 parts, 11 parts, Bulbus Allii, bamboo salt 14 parts, hyaluronic acid 4 parts, conch meal 7 parts, Oleum menthae 10 parts, xanthan gum 4 parts.
4. a preparation method for the powder of the control fragrant fish hemorrhagic disease according to any one of claim 1-3, is characterized in that: comprise the following steps:
(1) take Resina Liquidambaris, Rhizoma Dryopteris Crassirhizomatis and Spina Gleditsiae according to proportioning, pulverize putting into pulverizer after Resina Liquidambaris, Rhizoma Dryopteris Crassirhizomatis and Spina Gleditsiae mix homogeneously and cross 100 mesh sieves, obtaining comminuted powder;
(2) by mass concentration be 50% ethanol add in Chinese medicine extracting tank, ethanol consumption is 10 times of the comminuted powder weight of step (1) gained, open and stir, the comminuted powder of step (1) gained is added in Chinese medicine extracting tank, temperature of charge in Chinese medicine extracting tank is warming up to 75-80 DEG C of constant temperature and extracts 30-40min, 100 orders cross leaching filtrate, and filtering residue returns in Chinese medicine extracting tank and repeats to extract once, 100 orders cross leaching filtrate, merge twice gained filtrate;
(3) Fructus Cnidii, Herba Epimeredis Indicae, Folium Mori, RADIX PEUCEDANI, Radix Ophiopogonis, Radix Oryzae Glutinosae, Fructus Momordicae charantiae, Rhizoma Phragmitis, Herba Astragali Melilotoidis (Herba Astragali Sinici), Herba Houttuyniae, Herba Plantaginis and Bulbus Allii is taken according to proportioning, gross weight is designated as 1 part, add 8 parts of purified water, 20-30 DEG C is soaked 6-9h, obtains soak;
(4) boil 2h after the soak that step (3) obtains being heated to boiling, be separated and take out fried liquid, continue the purified water adding 4 parts in medical material, continue to boil 1h after being heated to boiling, merge twice fried liquid and be extracting solution;
(5) take Periostracum Cicadae, Radix aconiti gymnandri, Resina Toxicodendri, Herba Portulacae, Radix Inulae, Cortex Moutan, Radix Sophorae Flavescentis, phellodendron bark and Rhizoma Kaempferiae respectively according to proportioning, load ball mill grinding 2h, cross 80 mesh sieves, obtain grounds travel;
(6) grounds travel that extracting solution step (4) obtained and step (5) obtain is positioned in the extraction kettle in supercritical extraction instrument, carbon dioxide is utilized to extract as medium, extraction kettle pressure is 40Mpa, extraction temperature is 45 DEG C, separator pressure 12Mpa, separator temperature is 70 DEG C, extracts 2 hours, is extracted liquid;
(7) bamboo salt, hyaluronic acid, conch meal, Oleum menthae and xanthan gum is taken according to proportioning, and mix homogeneously with the filtrate of step (2) gained, the extract of step (6) gained, by mixed liquor pressure be-0.06 ~-0.08Mpa, temperature is concentrated into thick viscous solution under being 40 ~ 45 DEG C of conditions, when the relative density of viscous solution is 45 DEG C 1.15 ~ 1.24;
(8) drying of the viscous solution of step (7) gained is removed moisture until moisture is less than 5%, Crushing of Ultrafine, to mean diameter less than 50 μm, obtains object.
CN201510970877.8A 2015-12-22 2015-12-22 Powder for preventing and treating plecoglossus altivelis hemorrhagic disease and preparation method thereof Withdrawn CN105381356A (en)

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CN112370512A (en) * 2020-09-02 2021-02-19 湖南康大生物药品有限责任公司 Powder for preventing and treating hemorrhagic disease of plecoglossus altivelis and preparation method thereof

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CN104208453A (en) * 2013-09-30 2014-12-17 郑州后羿制药有限公司 Traditional Chinese medicine composition for preventing grass carp hemorrhagic disease and preparation method thereof
CN104435594A (en) * 2014-11-04 2015-03-25 占水秀 Medicine for treating viral hemorrhagic disease of trionyx sinensis
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Publication number Priority date Publication date Assignee Title
CN102526207A (en) * 2010-12-15 2012-07-04 戚冬梅 Prescription for treating fish hemorrhagic disease
CN102908342A (en) * 2012-11-20 2013-02-06 上海海洋大学 Medicine for preventing hemorrhagic disease of grass carps
CN104208453A (en) * 2013-09-30 2014-12-17 郑州后羿制药有限公司 Traditional Chinese medicine composition for preventing grass carp hemorrhagic disease and preparation method thereof
CN104435594A (en) * 2014-11-04 2015-03-25 占水秀 Medicine for treating viral hemorrhagic disease of trionyx sinensis
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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112370512A (en) * 2020-09-02 2021-02-19 湖南康大生物药品有限责任公司 Powder for preventing and treating hemorrhagic disease of plecoglossus altivelis and preparation method thereof

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Application publication date: 20160309