CN105709071A - Medicine for treating postnatal constipation and preparation method of medicine - Google Patents

Medicine for treating postnatal constipation and preparation method of medicine Download PDF

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Publication number
CN105709071A
CN105709071A CN201610231143.2A CN201610231143A CN105709071A CN 105709071 A CN105709071 A CN 105709071A CN 201610231143 A CN201610231143 A CN 201610231143A CN 105709071 A CN105709071 A CN 105709071A
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weight portion
radix
medicine
fructus
herba
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白娜
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Yantai Minwang Electromechanical Technology Co Ltd
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Yantai Minwang Electromechanical Technology Co Ltd
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/34—Campanulaceae (Bellflower family)
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    • A61K35/644—Beeswax; Propolis; Royal jelly; Honey
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Abstract

The invention discloses a medicine for treating postnatal constipation and a preparation method of the medicine. The medicine is prepared from raw materials as follows: pilose asiabell roots, milkvetch roots, Chinese red dates, manyprickle acanthopanax roots, roots of kirilow rhodiola, fructus hippophae, honey, prepared rehmannia roots, white peony roots, coastal glehnia roots, lilies, dwarf lilyturf tubers, herba dendrobii, fragrant solomonseal rhizomes, herba ecliptae, fructus ligustri lucidi, mulberries, black sesame, senna leaves, aloes, pine nuts, herba pyrolae, fruits of Fiveleaf Akebia, Chinese angelica, herba cynomorii, common russianthistle herbs and hericium erinaceus. The medicine has the benefits as follows: the medicine accords with the traditional Chinese medicine theories, mainly has the functions of replenishing blood, promoting secretion of body fluids, moistening intestines and relaxing bowels and has the advantages of fast effect, definite curative effect, high safety, no toxic and side effect and impossibility of relapse when used for treating postnatal constipation.

Description

For medicine treating puerperal constipation and preparation method thereof
This case is divisional application, and the denomination of invention of original application is: for pharmaceutical composition treating puerperal constipation and preparation method thereof, the applying date of original application is: 2014-05-05, and the application number of original application is: 201410185302.0.
Technical field
The present invention relates to pharmaceutical technology, particularly relate to a kind of medicine for treating puerperal constipation and preparation method.
Background technology
Puerperal constipation refers to puerpera defecates puerperal to be stranded in the enteral time excessively of a specified duration, causes constipation obstructed, and defecation time extends, though or have awareness of defecation difficult defecation, be clinical obstetrics common disease, be again difficult disease, be new produce one of three diseases.The general diet of primary disease is as usual, sees without card companions such as stomachache, vomitings.Different with the constipation that other diseases causes, it brings great misery to puerpera on body & mind.
The cause of disease that primary disease produces is mainly thin fluid injury in puerperal, and intestinal loses profit；Or the element official report deficiency of vital energy, more to hinder because producing yang-energy, the deficiency of vital energy is unable pushes stool, just in colon, stops up under stagnant difficulty.The reason of puerperal constipation can be divided into following 4 kinds of situations: 1, owing to gastrointestinal function in puerperal weakens, and enterokinesia is slow, and intestinal contents is long in the enteral time of staying, makes moisture absorption cause constipation with dry stool.2, through gestation abdominal part excessive expansion, abdominal muscles and pelvic floor tissue is made to relax, defecation diminished strength.3, human body in puerperal weakness defecation diminished strength.So often there is constipation phenomenon in puerperal.4, dietary structure is unreasonable, and veterinary antibiotics eats like a bird.5, out-of-bed activity inconvenience, many puerperas are uncomfortable again uses bedpan defecation in bed.
At present, clinical treatment doctor trained in Western medicine many employings glycerin, its mechanism of action is the height concentration and the hypertonicity that utilize glycerol or sorbitol, allowing more moisture penetrate into enteric cavity, thus softening stool, stimulating intestinal mucosa, reflexive ground stimulates enterokinesia, causes defecation to react, and allows more moisture penetrate into enteric cavity, thus softening stool, stimulating intestinal mucosa, reflexive ground stimulates enterokinesia, causes defecation to react, add and there is lubrication, make stool be easily drained external.But these effects of glycerin are only cured the symptoms, not the disease, if life-time service, even if escalated dose also can become do not have effect, increase the weight of constipation on the contrary.Puerpera's thin fluid injury in puerperal, deficiency of qi and blood, simple use physical stimulation is often difficult to reach ideal effect, and uses puerperal medicine for external use easily human body to be caused damage, uses inconvenience, and compliance is poor；For above-mentioned drawback, people thirst for finding the ideal medicament of a kind of determined curative effect, toxic and side effects treatment puerperal constipation little, easy to use.
Summary of the invention
The technical problem to be solved is in that, a kind of medicine treating puerperal constipation and preparation method thereof is provided, this pharmaceutical composition is based on enriching blood and promoting secretion of body fluid, loosening bowel to relieve constipation, and treatment puerperal constipation has rapid-action, determined curative effect, safety is high, the advantage that has no side effect and not easily recur.
In order to solve above-mentioned technical problem, the invention provides a kind of medicine for treating puerperal constipation, wherein, including following raw medicinal material: Radix Codonopsis, the Radix Astragali, Fructus Jujubae, Radix Et Caulis Acanthopanacis Senticosi, Radix Rhodiolae, Fructus Hippophae, Mel, Radix Rehmanniae Preparata, the Radix Paeoniae Alba, Radix Glehniae, Bulbus Lilii, Radix Ophiopogonis, Herba Dendrobii, Rhizoma Polygonati Odorati, Herba Ecliptae, Fructus Ligustri Lucidi, Fructus Mori, Semen Sesami Nigrum, Folium Sennae, Aloe and Semen pini koraiensis.
In described pharmaceutical composition, the parts by weight of each raw medicinal material are preferably: Radix Codonopsis 15-25 weight portion, Radix Astragali 10-20 weight portion, Fructus Jujubae 10-25 weight portion, Radix Et Caulis Acanthopanacis Senticosi 10-20 weight portion, Radix Rhodiolae 15-20 weight portion, Fructus Hippophae 10-20 weight portion, Mel 1-5 weight portion, Radix Rehmanniae Preparata 10-20 weight portion, Radix Paeoniae Alba 15-25 weight portion, Radix Glehniae 10-20 weight portion, Bulbus Lilii 10-20 weight portion, Radix Ophiopogonis 15-20 weight portion, Herba Dendrobii 10-15 weight portion, Rhizoma Polygonati Odorati 5-15 weight portion, Herba Ecliptae 5-10 weight portion, Fructus Ligustri Lucidi 10-20 weight portion, Fructus Mori 15-25 weight portion, Semen Sesami Nigrum 15-25 weight portion, Folium Sennae 10-20 weight portion, Aloe 10-20 weight portion and Semen pini koraiensis 10-20 weight portion.
In described pharmaceutical composition, the parts by weight of each raw medicinal material can also be preferably: Radix Codonopsis 19 weight portion, the Radix Astragali 15 weight portion, Fructus Jujubae 17 weight portion, Radix Et Caulis Acanthopanacis Senticosi 15 weight portion, Radix Rhodiolae 17 weight portion, Fructus Hippophae 15 weight portion, Mel 3 weight portion, Radix Rehmanniae Preparata 15 weight portion, the Radix Paeoniae Alba 21 weight portion, Radix Glehniae 15 weight portion, Bulbus Lilii 15 weight portion, Radix Ophiopogonis 17 weight portion, Herba Dendrobii 12 weight portion, Rhizoma Polygonati Odorati 10 weight portion, Herba Ecliptae 8 weight portion, Fructus Ligustri Lucidi 15 weight portion, Fructus Mori 20 weight portion, Semen Sesami Nigrum 19 weight portion, Folium Sennae 15 weight portion, Aloe 15 weight portion and Semen pini koraiensis 15 weight portion.
Described pharmaceutical composition also includes: Herba Pyrolae, Fructus Akebiae, Radix Angelicae Sinensis, Herba Cynomorii, Herba Salsolae Collinae and Hericium erinaceus (Bull. Ex Fr.) Pers..
In described pharmaceutical composition, the parts by weight of each raw medicinal material are preferably: Radix Codonopsis 15-25 weight portion, Radix Astragali 10-20 weight portion, Fructus Jujubae 10-25 weight portion, Radix Et Caulis Acanthopanacis Senticosi 10-20 weight portion, Radix Rhodiolae 15-20 weight portion, Fructus Hippophae 10-20 weight portion, Mel 1-5 weight portion, Radix Rehmanniae Preparata 10-20 weight portion, Radix Paeoniae Alba 15-25 weight portion, Radix Glehniae 10-20 weight portion, Bulbus Lilii 10-20 weight portion, Radix Ophiopogonis 15-20 weight portion, Herba Dendrobii 10-15 weight portion, Rhizoma Polygonati Odorati 5-15 weight portion, Herba Ecliptae 5-10 weight portion, Fructus Ligustri Lucidi 10-20 weight portion, Fructus Mori 15-25 weight portion, Semen Sesami Nigrum 15-25 weight portion, Folium Sennae 10-20 weight portion, Aloe 10-20 weight portion, Semen pini koraiensis 10-20 weight portion, Herba Pyrolae 10-20 weight portion, Fructus Akebiae 15-25 weight portion, Radix Angelicae Sinensis 10-20 weight portion, Herba Cynomorii 15-20 weight portion, Herba Salsolae Collinae 10-15 weight portion and Hericium erinaceus (Bull. Ex Fr.) Pers. 10-25 weight portion.
In described pharmaceutical composition, the parts by weight of each raw medicinal material can also be preferably: Radix Codonopsis 19 weight portion, the Radix Astragali 15 weight portion, Fructus Jujubae 17 weight portion, Radix Et Caulis Acanthopanacis Senticosi 15 weight portion, Radix Rhodiolae 17 weight portion, Fructus Hippophae 15 weight portion, Mel 2 weight portion, Radix Rehmanniae Preparata 15 weight portion, the Radix Paeoniae Alba 21 weight portion, Radix Glehniae 15 weight portion, Bulbus Lilii 15 weight portion, Radix Ophiopogonis 17 weight portion, Herba Dendrobii 12 weight portion, Rhizoma Polygonati Odorati 10 weight portion, Herba Ecliptae 8 weight portion, Fructus Ligustri Lucidi 15 weight portion, Fructus Mori 20 weight portion, Semen Sesami Nigrum 19 weight portion, Folium Sennae 15 weight portion, Aloe 15 weight portion, Semen pini koraiensis 15 weight portion, Herba Pyrolae 15 weight portion, Fructus Akebiae 21 weight portion, Radix Angelicae Sinensis 15 weight portion, Herba Cynomorii 17 weight portion, Herba Salsolae Collinae 12 weight portion and Hericium erinaceus (Bull. Ex Fr.) Pers. 17 weight portion.
In order to better realize foregoing invention purpose, the invention provides a kind of medicine for treating puerperal constipation, the dosage form of described medicine is tablet, and its preparation method comprises the following steps:
The first step, is mixed in proportion each for described Chinese medicine raw medicinal material, adds the ethanol that determining alcohol is 85%～90% relative to mixture quality 4～5 times, is heated to reflux 2～4 hours, extracts, and filters and obtains the first extracting solution；Filter the medicinal residues obtained and add the ethanol that determining alcohol is 90%～95% relative to described medicinal residues quality 2～3 times, be heated to reflux 1～3 hour, extract, filter and obtain the second extracting solution；First extracting solution and the second extracting solution being merged, concentrating under reduced pressure removes alcohol solvent, dry, it is thus achieved that dry cream；
Second step, is placed in super micron mill by the dry cream that the first step obtains and pulverizes 2～3 hours, pulverizes, sieves, it is thus achieved that the micropowders of 300 order～400 orders；
3rd step, the micropowders that second step is obtained, add relative to the microcrystalline Cellulose of its quality 0.1～0.3 times, 0.15～0.3 times of lactose, the starch of 0.2～0.35 times, sieve, mix homogeneously, granulate, dry, add relative to 0.025～0.04 times of magnesium stearate of micropowders quality, granulate, tabletting, makes.
The dosage form of described medicine is oral solutions, and its preparation method comprises the following steps:
The first step, Radix Codonopsis, the Radix Astragali and Radix Et Caulis Acanthopanacis Senticosi are mixed in proportion, with the methanol that determining alcohol is 70%～80% as solvent, adopt percolation with the speed slowly percolation of 1～3ml per minute, collecting percolate, concentrating under reduced pressure also dries, it is thus achieved that dry cream, being ground into powder, the quality of affiliated methanol is 3～5 times of first step mixture quality；
Second step, is mixed in proportion Fructus Jujubae, Radix Rhodiolae, Fructus Hippophae, Radix Rehmanniae Preparata, the Radix Paeoniae Alba, Radix Glehniae, Bulbus Lilii, Radix Ophiopogonis, Herba Dendrobii, Rhizoma Polygonati Odorati, Herba Ecliptae, Fructus Ligustri Lucidi, Fructus Mori, Semen Sesami Nigrum, Folium Sennae, Aloe and Semen pini koraiensis, is ground into powder；
3rd step, adds the distilled water of the powder quality 3～6 times obtained relative to second step, decocts 2～4 hours, filters, it is thus achieved that the first filtrate；Filtering residue is added the distilled water relative to its quality 2～4 times, decocts 1～2 hour, filter, it is thus achieved that the second filtrate；Merging the first filtrate and the second filtrate, concentrate away the water of 2/3～3/4 volume, adding determining alcohol is the ethanol of 90～95%, makes determining alcohol reach 70%～80%, stands 12～24 hours, filters, concentrating under reduced pressure, dry, it is thus achieved that dry cream, is ground into powder；
4th step, the powder mixing that the first step and the 3rd step are obtained, add the distilled water relative to powder mixing quality 3～5 times amount, the Mel of described weight portion, and the sodium benzoate of powder mixing quality 0.01～0.02 times, stirring, boil, cooling, filtering, subpackage, namely sterilizing obtains oral liquid.
The dosage form of described medicine is enema, and its preparation method comprises the following steps: all described raw medicinal materials add the water soaking 30 minutes to 1 hour of 2-5 times, heated and boiled 30～40 minutes, and filtration, filtrate is standby；Filtering residue adds the water of filtering residue 2-4 times, second time heated and boiled 30～40 minutes, filters, and filtrate is standby；Filtering residue adds the water of filtering residue 2-4 times, third time heated and boiled 30～40 minutes, filters；Three filtrates being combined, heating is concentrated into pasty state medicinal liquid.
The technical scheme that the embodiment of the present invention provides has the benefit that drug utilization China Traditional Chinese medical theory of the present invention, based on enriching blood and promoting secretion of body fluid, loosening bowel to relieve constipation, treatment puerperal constipation has rapid-action, determined curative effect, safety is high, the advantage that has no side effect and not easily recur.
Detailed description of the invention
The invention provides a kind of medicine for treating puerperal constipation, including Radix Codonopsis, the Radix Astragali, Fructus Jujubae, Radix Et Caulis Acanthopanacis Senticosi, Radix Rhodiolae, Fructus Hippophae, Mel, Radix Rehmanniae Preparata, the Radix Paeoniae Alba, Radix Glehniae, Bulbus Lilii, Radix Ophiopogonis, Herba Dendrobii, Rhizoma Polygonati Odorati, Herba Ecliptae, Fructus Ligustri Lucidi, Fructus Mori, Semen Sesami Nigrum, Folium Sennae, Aloe and Semen pini koraiensis；Preferably, pharmaceutical composition also includes: Herba Pyrolae, Fructus Akebiae, Radix Angelicae Sinensis, Herba Cynomorii, Herba Salsolae Collinae and Hericium erinaceus (Bull. Ex Fr.) Pers..
The pharmacological property of above-mentioned raw materials medical material is as follows:
Radix Codonopsis: property is put down, sweet in the mouth, micro-acid；Return spleen, lung meridian.Invigorating the spleen and replenishing QI, spleen invigorating lung benefiting.For deficiency of the spleen and lung, cardiopalmus of breathing hard, anorexia and loose stool, dyspnea due to deficiency is coughed, and interior-heat is quenched one's thirst.These product are clinical conventional Qi-tonifying drug, and function invigorating the spleen to benefit the lung, effect person of modern times joins and is more weak, it is adaptable to various deficiency of vital energy deficiency persons.Human body multi viscera is had strong effect in various degree by contained saponin, inulin, Alkaloid, starch etc., can improve the adaptability of human body.Having antiulcer, can increase intestinal tension force, regulate stomach motion, reuse the intestines and stomach regulation of mental activities agent of Radix Codonopsis to chronic diarrhea, ulcerative colitis, antral gastritis in the intestines and stomach coordinating preparation, chronic atrophic gastritis etc. quite has effect.Additionally, these product are also normal and the eliminating evil medicine compatibility such as diaphoretic medicine, cathartic drug, the card that the dominations of pathogen such as deficiency of qi and blood are weakened body resistance for deficiency of vital energy diseases caused by exogenous pathogenic factor or interior-excess accumulation of heat, with strengthening vital QI to eliminate pathogenic factors, make to attack heresy and healthy energy is not hindered.
The Radix Astragali: sweet, tepor；Return lung, spleen, liver, kidney channel.Essentials of Matea Medica: " lossless energy is sent out for the Radix Astragali, life consolidating superficial resistance, has antiperspirant to stop；Process with invigorating middle warmer, benefit vigour, strong taste.Hemopoietic, granulation promoting, evacuation of pus expelling the toxic substance from the body with tonic, carbuncle sore panacea.Variola does not rise, and yang deficiency should it without hot person." " book on Chinese herbal medicine justice ": " all middle gas is depressed, and spleen soil is weak for the Radix Astragali, soil, replenishing vital QI with drugs of warm nature taste in tonification, and sagging person is the most suitable for clearing heat in QI system.The skin table muscle of the through people of its skin, solid protection defends sun, and substantial table divides, and is its speciality, so all diseases of exterior deficiency, the most god's agent." function consolidating superficial resistance arresting sweating, inducing diuresis to remove edema, holds in the palm skin ulcer evacuation of pus, regulating fluid apssage.The Radix Astragali makes contractile ability strengthen, and can improve the blood circulation of whole body, can coronary artery dilator, Renal vascular and Rhizoma Bistortae peripheral vessel, make cutaneous circulation vigorous；The nonspecific immunity power of body can be improved, protect the liver and drop hypoglycemic effect, staphylococcus, blood dissolubility streptococcus, Diplococcus pneumoniae, dysentery bacterium etc. are had inhibitory action.The Radix Astragali can appreciable impact splenocyte Information Conduction, it is achieved immunoregulation effect.Can be used for hypertension, ischemic heart desease, acute glomerulonephritis, gastric ulcer, psoriasis, diabetes, osteoporosis." Bencao Jingshu ": " function reality table, person does not use pathogenic factor in the exterior；Helping gas, QI excess person does not use；Interior filling in, tonifying for the deficiency, chest and diaphragm is gas-tight asks, the intestines and stomach has stagnant person not use；Energy YANG invigorating, overabundance of YANG leading to deficiency of YIN person avoids it；Part of the body cavity above the diaphragm housing the heart and lungs intenseness of heat, part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels deficiency and coldness person avoids it；The many anger of patient, disharmony in liver-QI person do not take；Variola blood system heat notably disables."
Fructus Jujubae: sweet in the mouth, warm in nature, enter spleen, stomach warp.There is the effect of air making-up and spleen enlivening, nourishing blood to tranquillize the mind, harmonizing yingfen and weifen, the mitigation property of medicine, for weakness of the spleen and stomach, fatigue and asthenia, anorexia and loose stool, insufficiency of vital energy and blood, have a headache and fever, sweating hot blasts etc. are demonstrate,proved, and Fructus Jujubae has the effect of muscle strength reinforcing, have increase total serum protein and albuminous function.Cyclic adenosine monophosphate contained by Fructus Jujubae, is the required composition of human body cell energy metabolism, it is possible to muscle strength reinforcing, allaying tiredness, expansion blood vessel, increases myocardial contraction, improve myocardial nutrition, and preventing and treating cardiovascular system diseases is had good effect；The diseases such as chronic hepatitis, liver cirrhosis, anemia, anaphylactoid purpura are had good therapeutic effect by Fructus Jujubae；Fructus Jujubae contains triterpenoid compound and cyclic adenosine monophosphate, has stronger anticancer, anti-allergic effects.Fructus Jujubae can moisten cardiopulmonary, cough-relieving, tonifying five ZANG-organs, it is deficient to control, except the intestines and stomach addiction gas, moreover it is possible to regulating the spleen and stomach supports spleen, flat gastric qi, logical nine orifices, help 12 through etc..
Radix Et Caulis Acanthopanacis Senticosi: acrid in the mouth, hardship, micro-sweet, warm in nature, enter spleen, kidney, heart channel, there is replenishing QI to invigorate the spleen, tonifying the kidney for tranquilization, effect of expelling wind and removing dampness, demonstrate,prove for anemofrigid-damp arthralgia, lumbocrural pain, muscles and bones flaccidity is soft, be slow in action, body weakness with emaciation is weak, traumatic injury, fracture, edema, beriberi, uncontrolled urination are itched etc..The sweet A of Radix Et Caulis Acanthopanacis Senticosi is carotene, also containing this constituents in people.The excretion of cholesterol can be promoted in human body, the too high disease of blood cholesterol level can be prevented and treated.The sweet B of Radix Et Caulis Acanthopanacis Senticosi is Syringa oblata Lindl. element (Syringin), is the main strong composition of Radix Et Caulis Acanthopanacis Senticosi, has short gonad, radioprotective, fatigue-resisting function, has the physiologically active similar to people Saponin.Radix Et Caulis Acanthopanacis Senticosi is containing super oxidation disproportionation ferment SOD (Superoxidedimutase) complex, SOD has good anti-oxidation function, human immunity and the effect of opposing free radical attack can be strengthened, there is antioxidation, body immunity can be strengthened, prevent aging and promote health.
Radix Rhodiolae: sweet, bitter, flat；Return lung, heart channel.Radix Rhodiolae is dry root and the rhizome of crassulaceae plants Radix Rhodiolae, effect of Radix Rhodiolae and effect be can the kidney invigorating, regulate the flow of vital energy and nourish blood, have promoting blood circulation and hemostasis, clearing away lung-heat to relieve cough, antipyretic, and the effect under leukorrhagia stopping, the side effect of Radix Rhodiolae does not temporarily find.Radix Rhodiolae can improve sleep, detumescence is become silted up in blood-enriching and blood-promoting circulation, anti-cerebral anoxia, resisting fatigue, promoting blood circulation and hemostasis, clearing away lung-heat to relieve cough, change, antipyretic bring down a fever, nourishes the effects such as vigour；It is used for outward treating traumatic injury and burn and scald.Research points out that Oxidation is in a lot of advancing of disease processes, plays highly important role, for instance cancer, cardiovascular diseases, diabetes, nerve degeneration and rheumatoid arthritis etc..In traditional medicine, Radix Rhodiolae is also for treating diabetes.Relevant experiment utilizes mouse to make object, and test Radix Rhodiolae is movable to controlling the glycemic index of type-II diabetes, ferment and some antioxidative.
Fructus Hippophae: Fructus Hippophae and oil have significantly high medical value, it is possible to decrease cholesterol, and allevating angina pectoris shows effect, and also have the effect preventing and treating coronary atherosclerotic heart disease；Have and eliminate the phlegm, cough-relieving, relieving asthma and treat the effect of chronic tracheitis；Gastric duodenal ulcer and dyspepsia etc. can be treated, the diseases such as chronic superficial gastritis, atrophic gastritis, colitis is evident in efficacy；To burn, scald, cutter burns, cold injury has good therapeutical effect；Cervical erosion is had good therapeutic effect.Containing 7 kinds of Endospermum chinense Benth. materials such as isorhamnetin and glucoside, Quercetin, nimbecetin in sea buckthorn fruit, there is cough-relieving, relieving asthma and eliminate the phlegm, expand coronary vasodilator, reduce the usefulness of cholesterol, be usually used in treatment ischemic heart desease, treatment angina pectoris effective percentage is reached 94%.In Fructus Hippophae, SOD active component enriches, and every gram of sea-buchthorn fresh fruit SOD content reaches 2746.0 enzyme units, and its content is 4 times of Radix Ginseng.It can block the free radical because substance in vivo peroxidating produces, and this free radical is closely related with the generation of human senility, disease.
Mel: sweet in the mouth, property are flat.Spleen, stomach, lung, large intestine channel.Some chronic disease is also had certain curative effect by Mel.Informal dress Mel has good medical assistance effect for heart disease, hypertension, pneumonopathy, oculopathy, hepatopathy, dysentery, constipation, anemia, nervous system disease, gastric duodenal ulcer disease etc..The several years at room temperature placed by high-quality Mel will not be corrupt, it was shown that its antisepsis is extremely strong.It is experimentally confirmed that the gram positive bacterias such as streptococcus, staphylococcus, diphtheria are had stronger inhibitory action by Mel.Research proves, gastrointestinal function is had adjustment effect by Mel, and gastric acid secretion can be made normal.Zoopery confirms, Mel has the effect strengthening enterokinesia, can significantly shorten defecation time.
Radix Rehmanniae Preparata: sweet in the mouth, slightly warm in nature, enter liver, kidney channel, Compendium of Material Medica: " fill out bone marrow, longue meat, promoting generation of vital essence and blood.Tonifying five ZANG-organs internal injury is not enough, promoting blood circulation, and profit knowledge, black beard and hair, man's five kinds of strain and seven kinds of impairment, woman's damaging the spleen and stomach threatened abortion, irregular menorrhea, tire produces all kinds of diseases and ailments." there is YIN nourishing of enriching blood, benefit essence fills out the effect of marrow, for blood deficiency and yellow complexion；Dizziness, cardiopalmus, insomnia, menoxenia, collapse more than；Hepatic and renal YIN deficiency, night sweat, foot knee joint pain, soreness of the waist and knees, Hiccough and deaf, the cards such as the head is dim-sighted, sexual impotence of passing out semen, infertility, menoxenia, metrostaxis, and early whitening of beard and hair is quenched one's thirst, dyspnea with rapid and short breath of suffering from a deficiency of the kidney.This product character is sticky, and relatively Radix Rehmanniae is more very, hinders digestion, and all stagnation of QI abundant expectoration, abdominal distention, anorexia and loose stool person avoid clothes.Reuse for a long time clothes should with Pericarpium Citri Reticulatae, fry core and be equal to use, it is prevented that sticky hinder stomach.Radix Rehmanniae Preparata decoct treatment hypertension, blood pressure, serum cholesterol and triglyceride all have decline, and rheoencephalogram and electrocardiogram also make moderate progress.Radix Rehmanniae Preparata can significantly inhibit liver hemorrhagic necrosis stove and simple necrosis.Wine Radix Rehmanniae Preparata and cook Radix Rehmanniae and have a significant hypotensive effect, shrinks pressure and diastolic pressure is all remarkably decreased.
The Radix Paeoniae Alba: bitter in the mouth, acid, cold nature, enters liver, spleen channel, joint venture of nourishing blood, easing the affected liver to relieve pain, and the effect of suppressing liver-YANG is mainly used in deficiecny of liver-YIN, the headache feeling of fullness in the head of excessive rising of liver-YANG, vertigo and tinnitus, irritable；Deficiency of liver-blood, battalion defends the menoxenia of inanition, metrorrhagia and metrostaxis；The dysmenorrhea of deficiency of the liver stasis dampness；Disharmony of nutrient QI with defensive QI, the cloudy outer inducing vomiting spontaneous sweating of battalion；The gastral cavity abdomen pain over the hypochondriac region of depression of liver-QI, dysentery is suffered from abdominal pain；Deficiency and exhaustion of liver-YIN, passages through which vital energy circulates loses the card such as carpopedal spasm pain supported, and paeoniflorin has antibacterial, antipyretic, antiinflammatory, increase coronary flow, improves myocardial nutritional flow, expansion blood vessel, antagonism acute myocardial ischemia, suppress the effect of platelet aggregation, calmness, analgesia, spasmolytic, antiulcer, adjustment blood glucose.There are antithrombus formation and hepatoprotective effect, dysentery bacterium, Bacillus typhi, blood dissolubility streptococcus, Diplococcus pneumoniae, bacillus pyocyaneus, staphylococcus aureus are had inhibitory action.
Radix Glehniae: cold nature, sweet in the mouth, micro-hardship.Nourishing YIN and clearing away lung-heat, reinforcing stomach reg fluid.Thirsty for lung-heat type cough, chronic cough expectorant blood, calentura Tianjin wound.The compositions such as Radix Glehniae contains volatile oil, coumarin, starch, alkaloid, triterpenic acid, stigmasterol, each sterol, Radix Adenophorae (Radix Glehniae) element.It is demonstrated experimentally that Radix Glehniae can improve T cell ratio, improve lymhocyte transformation rate, leukocyte increasing, strengthen macrophage function, extend antibody and there is the time, improve B cell, promote immunologic function.Radix Glehniae can strengthen healthy energy, reduces disease, the generation of prophylaxis of cancer.
Bulbus Lilii: Bulbus Lilii is except containing protein 21.29%, fat 12.43%, reducing sugar 11.47%, starch 1.61%, and calcium, phosphorus, ferrum, every hectogram containing nutrients such as 1.443 milligrams of vitamin Bs, 21.2 milligrams of vitamin Cs outside, possibly together with the nutritional labeling that some are special, such as multiple alkaloids such as colchicine.These composition comprehensive functions, in human body, not only have the merit of good nutritious tonifying, but also multiple Seasonal diseases that is dry in autumn and that cause are had certain preventive and therapeutic effect.The traditional Chinese medical science being said, fresh Bulbus Lilii has tranquilizing by nourishing the heart, effect of nourishing the lung to arrest cough, weakling after being ill is highly profitable.
Radix Ophiopogonis: property hardship sweet, micro-, it is slightly cold；GUIXIN, lung, stomach warp.There is YIN nourishing and the production of body fluid promoting, effect that lung moistening clears away heart-fire, can be used for sore throat pharyngalgia, Tianjin wound is thirsty, and interior-heat is quenched one's thirst, vexed insomnia, dryness of the intestine constipation etc..Clear the moon supporting lung stomach goes heart use more, and YIN nourishing clears away heart-fire the use that connects with the heart more.These product are sweet cold clear and rich, kind control deficiency of stomach-Yin, and dry tongue is thirsty, the indigestion and loss of appetite card such as not hungry.Deficiency of YIN dryness of the intestine is controlled, constipation person additionally, can also be used with.Modern study shows, can improve immunologic function Radix Ophiopogonis, various bacteria has inhibitory action, can strengthen pituitary adrenal system function, improve organism adaptation ability.The diseases such as joining Radix Adenophorae (Radix Glehniae) Radix Ophiopogonis, lung stomach is ruled together, and has the cool stomach of lung heat clearing, the good effectiveness of YIN nourishing and the production of body fluid promoting, the few expectorant of the dry cough caused by lung-dryness syndrome due to deficiency of YIN or thermal burn lung yin, dry laryngopharynx.
Herba Dendrobii: cold nature, sweet in the mouth, return stomach, kidney channel, there is reinforcing stomach reg fluid, effect of nourishing YIN and clearing away heat.Cure mainly cloudy impairment of body fluid to lose, xerostomia excessive thirst, the cards such as lack of appetite is retched, deficiency-heat after being ill, poor vision.Herba Dendrobii can significantly improve superoxides discrimination China enzyme (SOD) level, reduces lipid peroxide (LPO), regulates brain monoaminergic transmitters level, it is suppressed that similar monoamine oxidase, MAO (MAO), plays the effect of slow down aging.Herba Dendrobii contains lactone component, has the effects such as blood circulation promoting and blood stasis dispelling, expansion blood vessel and antiplatelet condense, and treatment embolic occlusion pulse tube is scorching, cerebral thrombosis, arteriosclerotic obliteration.The luxuriant and rich with fragrance class extracted in Herba Dendrobii and bibenzyl material, have the effect of anti-lung cancer, adenocarcinoma ovaries and promyelocitic leukemia.Intestinal tube is had excitation by Herba Dendrobii, and shrinkage amplitude can be made to increase.Pharmacological testing shows, oral Herba Dendrobii decoct can promote gastric secretion, helps digest.
Rhizoma Polygonati Odorati: sweet in the mouth, property is put down；Attach to the lung and stomach meridians." property of medicine opinion ": " disease cold and heat time main, interior tonifying for the deficiency, remove asthenia exopathogenic heat, headache uneasiness, add and with good." " Japan hanako materia medica ": " relieving restlessness is vexed, quenches the thirst, and moistens cardiopulmonary, mends five kinds of strain and seven kinds of impairment, deficient, and waist foot pain pain, sky row is fanatical." Compendium of Material Medica: " main air temperature spontaneous perspiration is scorching hot, and malaria with general debility cold and heat, taste void is weary, man's frequent micturition, and consumption of essence, all are deficient." Rhizoma Polygonati Odorati sweet in the mouth greasiness, matter is soft and moistens, and is the good medicine of YIN nourishing and the production of body fluid promoting simply.. the steroid glycoside that Rhizoma Polygonati Odorati contains, the effect of cardiac muscle is similar with Herba Convallariae preparation.Isolated frog heart is had cardiotonic by Rhizoma Polygonati Odorati glycocide, and the effect of Rhizoma Polygonati Odorati decoct is similar with Rhizoma Polygonati Odorati glycocide.Rhizoma Polygonati Odorati extractum lumbar injection, can strengthen burned mice Peritoneal macrophages Phagocytosis, improves Hemolysin level, improves the splenocyte breeder reaction to ConA.These product have promotion laboratory animal antibody tormation, improve phagocytic percentage and the phagocytic index of macrophage, promote interferon synthesis, it is suppressed that growth of bacillus tubercle, blood sugar lowering, blood fat reducing, alleviates atherosclerotic plaque and is formed, make peripheral blood vessel and coronary dilation, extend hypoxia endurance time, heart tonifying, antioxidation, the anti-ageing effect of waiting for a long time.
Herba Ecliptae: cool in nature, sweet in the mouth acid.Tang Materia Medica: " main dysentery.Acupuncture skin ulcer is sent out, and flood blood the person of stopping can not apply it；Juice is coated with sends out an eyebrow, raw speed and numerous." " classifying herbal ": " hemostasis, the kidney invigorating, annealing, detumescence.Control pouring, collapse." there is effect of cooling blood for hemostasis, the kidney invigorating and essence nourishing, it is usually used in treatment haematemesis, epistaxis, hematuria, has blood in stool, the disease such as dysentery, knife injury are hemorrhage, early whitening of beard and hair, diphtheria, stranguria with turbid discharge, leukorrhagia, pudendum pruritus due to damp pathogen.Apply hemorrhage place with Fructus seu radix camptothecae acuminatae (Fructus Camptothecae Acuminatae) blade of grass powder and oppress a little, having good haemostatic effect.The acute liver damage of Carbon Tetrachloride Induced is had significant protective effect by the Female guinea pigs giving Herba Ecliptae extract in advance.Herba Ecliptae has the effect increasing guinea pig isolated heart coronary flow, makes ECG T wave improve.Herba Ecliptae can improve the survival rate of mice in hypobaric hypoxia situation；Also the life of mice in normobaric hypoxia situation can be obviously prolonged.
Fructus Ligustri Lucidi: sweet in the mouth, hardship, is slightly cold, and enters liver, kidney channel, has strong liver kidney tonifying, the effect of clearing away heat to improve acuity of vision, is mainly used in treatment hepatic and renal YIN deficiency, the symptoms such as the head loses foster giddy tinnitus, yin asthenia generating intrinsic heat.This product energy tonifying liver kidney yin, but the efficacy of a drug is gentle, must slowly take effect.Controlling poor vision, often join Radix Rehmanniae Preparata, Semen Cuscutae, Fructus Lycii is equal to use, controls early whitening of beard and hair, often joins Herba Ecliptae, and Fructus Mori are equal to use, control fever due to yin deficiency, often joins Cortex Lycii, and Radix Rehmanniae is equivalent to be used.Compendium of Material Medica is recorded: " it is verdant that winter insulted by this wood, has the behaviour that chastity is kept, therefore with Fructus Ligustri Lucidi shape it ... to put wax insect time near, therefore be commonly called as wax tree." Fructus Ligustri Lucidi can promote leukocyte, strengthens effect of immunologic function, staphylococcus aureus, dysentery bacterium are had stronger inhibitory action.Modern medicine study proves, Fructus Ligustri Lucidi includes ursolic acid, mannitol, glucose, fat wet goods, has heart tonifying, diuresis and hepatoprotective effect, the leukopenia quantity caused because of chemotherapy can be made to raise, and staphylococcus aureus, escherichia coli are had inhibitory action.
Fructus Mori: sweet, flat are nontoxic.Qi-restoratives QI invigorating, anhydrate gas.Folium Mori blood pressure lowering, liver heat removing and eyesight improving.RAMULUS MORI curing rheumatism, controls brachialgia.Cortex Mori diuresis, cough-relieving, control edema.Fatty acid in Fructus Mori has reducing fat, reduces blood fat, it is prevented that sclerosis of blood vessels etc. act on.Fructus Mori contains black hair element, and what can make that hair becomes is black and glossy.Fructus Mori has improves skin blood supply, nutrition skin, and make skin delicate and black hair etc. acts on, and can slow down aging.Fructus Mori has immunologic enhancement, it is possible to cancer-resisting.Fructus Mori is apt to nourishing YIN and benefiting blood, promotes the production of body fluid and moisturize, the disease such as be suitable to Liver and kidney deficiency of YIN-blood and body fluid deficiency is quenched one's thirst, dryness of the intestine.Often food Fructus Mori can improving eyesight, the symptom that relieving eye strain is dry and astringent.Ramulus Mori decocts juice, gives animal and is administered orally, it was demonstrated that making blood pressure drops effect, Cortex Mori also has hypotensive activity, but root and young sprout leaf are without hypotensive effect.
Semen Sesami Nigrum: sweet, flat.Return liver, kidney, large intestine channel.Invigorating the liver and kidney, benefiting essence-blood, intestine moistening is dry.For dizziness and blurred vision, Hiccough and deaf, early whitening of beard and hair, post disease alopecia, dryness of the intestine constipation.The multiple essential amino acid that Semen Sesami Nigrum contains, under the effect of vitamin E and vitamin B1 participates in, can accelerate the metabolic function of human body；Ferrum and vitamin E that Semen Sesami Nigrum contains are the important component preventing anemia, activating brain cell, elimination blood vessel cholesterol；The fat that Semen Sesami Nigrum contains is mostly unsaturated fatty acid, has the effect of life lengthening.Chinese medicine theory is thought, Semen Sesami Nigrum has invigorating the liver and kidney, moistening five ZANG-organs, physical strength profiting, longue meat, fills out the effect of brains, can be used for treating dizziness, early whitening of beard and hair, alopecia, soreness of the waist and knees, limbs fatigue caused by Liver and kidney asthenia of essence and blood, walk with difficulty, the dry dried and withered hairs of deficient five internal organs, skin, the disease such as dryness of the intestine constipation, effect in blacking hair and nourishing face, celebrated especially.
Folium Sennae: sweet, bitter, cold.Return large intestine channel.Cure mainly the row that purges heat stagnant, relieving constipation, diuretic.Stagnating for accumulation of heat, constipation is suffered from abdominal pain, edema distension.These product contain Sennoside A and Sennoside B, and containing Herba Alii fistulosi ketone derivatives: aloe-emodin, chrysophanol, chrysophanic acid etc..Having Folium Sennae and can make medicinal discharge function and antibacterial action, Folium Sennae also has curariform action mask.Being sprayed on gastrorrhagia place under gastroscope with this product infusion, direct-view has anastalsis at once as seen.
Aloe: bitter in the mouth is cold in nature, removing heat from the liver, relieving constipation, parasite killing；Additionally be used for having a headache, constipation, pediatric epilepsy scared, infantile malnutrition infections furuncle and phyma, burn and scald, tinea skin ulcer, hemorrhoid, atrophic rhinitis, scrofula, hepatitis, Biliary Calculi, exudative dermatitis etc..Containing having more than 200 kinds of compounds in the blade of Aloe, in the middle of include 20 kinds of mineral, 18 seed amino acids, 12 kinds of vitamin and other various different nutrients, including multiple mucopolysaccharide, fatty acid, Anthraquinones and flavone compound, sugar, organized enzyme etc..Anthraquinones has another name called Anthraquinone Complex, has effect of disinfection, is primarily present in juice.
Semen pini koraiensis: sweet, temperature.Lung moistening, laxation.For xeropulmonary cough, chronic constipation.Semen Pini has effect nourshing Yin and drynsessmoistening prescription, righting qi-restoratives, is particularly suitable for the patients such as body void, constipation, cough and eats.What is particularly worth mentioning is that, the defecating feces excretion of Semen Pini is gentle, thus be particularly suitable for getting old and weak, after being ill, the constipation person in puerperal eats.As desirable Semen pini koraiensis 20 grams pulverizes, cooking congee with Semen oryzae sativae 100 grams, a point morning and evening takes.Semen Pini is the high-quality supplementary of brain, is particularly suitable for brain overwork crowd and eats.Unsaturated fatty acid contained in Semen Pini has enhancing brain cell metabolism, safeguards the effect of function of brain cell and function of nervous system.Content of glutamic acid is up to 16.3%, and glutamic acid has good brain strengthening function, can memory reinforcing.Righting qi-restoratives, loosening bowel to relieve constipation, be best suitable for body void, constipation person eat.
Herba Pyrolae: sweet, bitter, temperature.Return liver, kidney channel.Function cures mainly: wind-damp dispelling, bone and muscle strengthening, hemostasis.For rheumatic arthralgia, weakness of the waist and knees, menorrhagia, chronic cough due to asthenia of viscera.
Fructus Akebiae: micro-hardship, property is put down.Return liver, stomach, bladder warp.Dispersing the stagnated liver-QI for regulating the stomach, promoting blood circulation and stopping pain, hard masses softening and resolving, diuresis.Main stagnation of liver-QI and stomach-QI, gastral cavity abdomen, the side of body help distending pain, and diet does not disappear, and dysentery is just let out, hernia pain, lumbago, amenorrhea dysmenorrhea, goiter scrofula, malignant tumor.
Radix Angelicae Sinensis: sweet, acrid, warm.Return liver, the heart, spleen channel.Replenishing and activating blood, menstruction regulating and pain relieving, loosening bowel to relieve constipation.For blood deficiency and yellow complexion, dizziness cardiopalmus, menoxenia, amenorrhea dysmenorrhea, asthenia cold abdominalgia, dryness of the intestine constipation, rheumatic arthralgia, injury from falling down, ulcer sores.Radix Angelicae Sinensis (processed with wine) promoting blood circulation to restore menstrual flow.For amenorrhea dysmenorrhea, rheumatic arthralgia, injury from falling down.
Herba Cynomorii: sweet, temperature.Return spleen, kidney, large intestine channel.Function cures mainly: kidney-replenishing, benefiting essence-blood, loosening bowel to relieve constipation.Soft for waist knee joint flaccidity, sexual impotence spermatorrhea, dryness of the intestine constipation.
Herba Salsolae Collinae: light；Cool in nature.Return Liver Channel.Function cures mainly: suppressing the hyperactive liver and subsiding YANG；Loosening bowel to relieve constipation.Main hypertension；How sick；Dizziness；Insomnia；Dryness of the intestine constipation
Hericium erinaceus (Bull. Ex Fr.) Pers.: sweet, flat.Function cures mainly: profit the five internal organs, aid digestion.Cure mainly dyspepsia, neurasthenia, physical weakness.
In described pharmaceutical composition, the parts by weight of each raw medicinal material are preferably: Radix Codonopsis 15-25 weight portion, Radix Astragali 10-20 weight portion, Fructus Jujubae 10-25 weight portion, Radix Et Caulis Acanthopanacis Senticosi 10-20 weight portion, Radix Rhodiolae 15-20 weight portion, Fructus Hippophae 10-20 weight portion, Mel 1-5 weight portion, Radix Rehmanniae Preparata 10-20 weight portion, Radix Paeoniae Alba 15-25 weight portion, Radix Glehniae 10-20 weight portion, Bulbus Lilii 10-20 weight portion, Radix Ophiopogonis 15-20 weight portion, Herba Dendrobii 10-15 weight portion, Rhizoma Polygonati Odorati 5-15 weight portion, Herba Ecliptae 5-10 weight portion, Fructus Ligustri Lucidi 10-20 weight portion, Fructus Mori 15-25 weight portion, Semen Sesami Nigrum 15-25 weight portion, Folium Sennae 10-20 weight portion, Aloe 10-20 weight portion and Semen pini koraiensis 10-20 weight portion.
In described pharmaceutical composition, the parts by weight of each raw medicinal material can also be preferably: Radix Codonopsis 19 weight portion, the Radix Astragali 15 weight portion, Fructus Jujubae 17 weight portion, Radix Et Caulis Acanthopanacis Senticosi 15 weight portion, Radix Rhodiolae 17 weight portion, Fructus Hippophae 15 weight portion, Mel 3 weight portion, Radix Rehmanniae Preparata 15 weight portion, the Radix Paeoniae Alba 21 weight portion, Radix Glehniae 15 weight portion, Bulbus Lilii 15 weight portion, Radix Ophiopogonis 17 weight portion, Herba Dendrobii 12 weight portion, Rhizoma Polygonati Odorati 10 weight portion, Herba Ecliptae 8 weight portion, Fructus Ligustri Lucidi 15 weight portion, Fructus Mori 20 weight portion, Semen Sesami Nigrum 19 weight portion, Folium Sennae 15 weight portion, Aloe 15 weight portion and Semen pini koraiensis 15 weight portion.
In described pharmaceutical composition, the parts by weight of each raw medicinal material are preferably: Radix Codonopsis 15-25 weight portion, Radix Astragali 10-20 weight portion, Fructus Jujubae 10-25 weight portion, Radix Et Caulis Acanthopanacis Senticosi 10-20 weight portion, Radix Rhodiolae 15-20 weight portion, Fructus Hippophae 10-20 weight portion, Mel 1-5 weight portion, Radix Rehmanniae Preparata 10-20 weight portion, Radix Paeoniae Alba 15-25 weight portion, Radix Glehniae 10-20 weight portion, Bulbus Lilii 10-20 weight portion, Radix Ophiopogonis 15-20 weight portion, Herba Dendrobii 10-15 weight portion, Rhizoma Polygonati Odorati 5-15 weight portion, Herba Ecliptae 5-10 weight portion, Fructus Ligustri Lucidi 10-20 weight portion, Fructus Mori 15-25 weight portion, Semen Sesami Nigrum 15-25 weight portion, Folium Sennae 10-20 weight portion, Aloe 10-20 weight portion, Semen pini koraiensis 10-20 weight portion, Herba Pyrolae 10-20 weight portion, Fructus Akebiae 15-25 weight portion, Radix Angelicae Sinensis 10-20 weight portion, Herba Cynomorii 15-20 weight portion, Herba Salsolae Collinae 10-15 weight portion and Hericium erinaceus (Bull. Ex Fr.) Pers. 10-25 weight portion.
In described pharmaceutical composition, the parts by weight of each raw medicinal material can also be preferably: Radix Codonopsis 19 weight portion, the Radix Astragali 15 weight portion, Fructus Jujubae 17 weight portion, Radix Et Caulis Acanthopanacis Senticosi 15 weight portion, Radix Rhodiolae 17 weight portion, Fructus Hippophae 15 weight portion, Mel 2 weight portion, Radix Rehmanniae Preparata 15 weight portion, the Radix Paeoniae Alba 21 weight portion, Radix Glehniae 15 weight portion, Bulbus Lilii 15 weight portion, Radix Ophiopogonis 17 weight portion, Herba Dendrobii 12 weight portion, Rhizoma Polygonati Odorati 10 weight portion, Herba Ecliptae 8 weight portion, Fructus Ligustri Lucidi 15 weight portion, Fructus Mori 20 weight portion, Semen Sesami Nigrum 19 weight portion, Folium Sennae 15 weight portion, Aloe 15 weight portion, Semen pini koraiensis 15 weight portion, Herba Pyrolae 15 weight portion, Fructus Akebiae 21 weight portion, Radix Angelicae Sinensis 15 weight portion, Herba Cynomorii 17 weight portion, Herba Salsolae Collinae 12 weight portion and Hericium erinaceus (Bull. Ex Fr.) Pers. 17 weight portion.
When the dosage form of pharmaceutical composition is tablet, its preparation method comprises the following steps:
The first step, is mixed in proportion each for described Chinese medicine raw medicinal material, adds the ethanol that determining alcohol is 85%～90% relative to mixture quality 4～5 times, is heated to reflux 2～4 hours, extracts, and filters and obtains the first extracting solution；Filter the medicinal residues obtained and add the ethanol that determining alcohol is 90%～95% relative to described medicinal residues quality 2～3 times, be heated to reflux 1～3 hour, extract, filter and obtain the second extracting solution；First extracting solution and the second extracting solution being merged, concentrating under reduced pressure removes alcohol solvent, dry, it is thus achieved that dry cream；
Second step, is placed in super micron mill by the dry cream that the first step obtains and pulverizes 2～3 hours, pulverizes, sieves, it is thus achieved that the micropowders of 300 order～400 orders；
3rd step, the micropowders that second step is obtained, add relative to the microcrystalline Cellulose of its quality 0.1～0.3 times, 0.15～0.3 times of lactose, the starch of 0.2～0.35 times, sieve, mix homogeneously, granulate, dry, add relative to 0.025～0.04 times of magnesium stearate of micropowders quality, granulate, tabletting, makes.
When the dosage form of pharmaceutical composition is oral solutions, its preparation method comprises the following steps:
The first step, Radix Codonopsis, the Radix Astragali and Radix Et Caulis Acanthopanacis Senticosi are mixed in proportion, with the methanol that determining alcohol is 70%～80% as solvent, adopt percolation with the speed slowly percolation of 1～3ml per minute, collecting percolate, concentrating under reduced pressure also dries, it is thus achieved that dry cream, being ground into powder, the quality of affiliated methanol is 3～5 times of first step mixture quality；
Second step, is mixed in proportion Fructus Jujubae, Radix Rhodiolae, Fructus Hippophae, Radix Rehmanniae Preparata, the Radix Paeoniae Alba, Radix Glehniae, Bulbus Lilii, Radix Ophiopogonis, Herba Dendrobii, Rhizoma Polygonati Odorati, Herba Ecliptae, Fructus Ligustri Lucidi, Fructus Mori, Semen Sesami Nigrum, Folium Sennae, Aloe and Semen pini koraiensis, is ground into powder；
3rd step, adds the distilled water of the powder quality 3～6 times obtained relative to second step, decocts 2～4 hours, filters, it is thus achieved that the first filtrate；Filtering residue is added the distilled water relative to its quality 2～4 times, decocts 1～2 hour, filter, it is thus achieved that the second filtrate；Merging the first filtrate and the second filtrate, concentrate away the water of 2/3～3/4 volume, adding determining alcohol is the ethanol of 90～95%, makes determining alcohol reach 70%～80%, stands 12～24 hours, filters, concentrating under reduced pressure, dry, it is thus achieved that dry cream, is ground into powder；
4th step, the powder mixing that the first step and the 3rd step are obtained, add the distilled water relative to powder mixing quality 3～5 times amount, the Mel of described weight portion, and the sodium benzoate of powder mixing quality 0.01～0.02 times, stirring, boil, cooling, filtering, subpackage, namely sterilizing obtains oral liquid.
When the dosage form of pharmaceutical composition is enema, its preparation method comprises the following steps: all described raw medicinal materials add the water soaking 30 minutes to 1 hour of 2-5 times, heated and boiled 30～40 minutes, and filtration, filtrate is standby；Filtering residue adds the water of filtering residue 2-4 times, second time heated and boiled 30～40 minutes, filters, and filtrate is standby；Filtering residue adds the water of filtering residue 2-4 times, third time heated and boiled 30～40 minutes, filters；Three filtrates being combined, heating is concentrated into pasty state medicinal liquid.
Embodiment 1 tablet
Embodiments provide a kind of pharmaceutical composition for treating puerperal constipation, the parts by weight of its raw medicinal material are: Radix Codonopsis 19 weight portion, the Radix Astragali 15 weight portion, Fructus Jujubae 17 weight portion, Radix Et Caulis Acanthopanacis Senticosi 15 weight portion, Radix Rhodiolae 17 weight portion, Fructus Hippophae 15 weight portion, Mel 3 weight portion, Radix Rehmanniae Preparata 15 weight portion, the Radix Paeoniae Alba 21 weight portion, Radix Glehniae 15 weight portion, Bulbus Lilii 15 weight portion, Radix Ophiopogonis 17 weight portion, Herba Dendrobii 12 weight portion, Rhizoma Polygonati Odorati 10 weight portion, Herba Ecliptae 8 weight portion, Fructus Ligustri Lucidi 15 weight portion, Fructus Mori 20 weight portion, Semen Sesami Nigrum 19 weight portion, Folium Sennae 15 weight portion, Aloe 15 weight portion and Semen pini koraiensis 15 weight portion.
Its preparation method comprises the following steps:
The first step, is mixed in proportion each for described Chinese medicine raw medicinal material, adds the ethanol that determining alcohol is 85% relative to mixture quality 5 times, is heated to reflux 3 hours, extracts, and filters and obtains the first extracting solution；Filter the medicinal residues obtained and add the ethanol that determining alcohol is 90% relative to described medicinal residues quality 2 times, be heated to reflux 2 hours, extract, filter and obtain the second extracting solution；First extracting solution and the second extracting solution being merged, concentrating under reduced pressure removes alcohol solvent, dry, it is thus achieved that dry cream；
Second step, is placed in super micron mill by the dry cream that the first step obtains and pulverizes 2 hours, pulverizes, sieves, it is thus achieved that the micropowders of 350 orders；
3rd step, the micropowders that second step is obtained, add relative to the microcrystalline Cellulose of its quality 0.2 times, 0.2 times of lactose, the starch of 0.3 times, sieve, mix homogeneously, granulates, dry, adds relative to 0.03 times of magnesium stearate of micropowders quality, granulate, tabletting, make.
Embodiment 2 oral solutions
Embodiments provide a kind of pharmaceutical composition for treating puerperal constipation, the parts by weight of its raw medicinal material are: Radix Codonopsis 19 weight portion, the Radix Astragali 15 weight portion, Fructus Jujubae 17 weight portion, Radix Et Caulis Acanthopanacis Senticosi 15 weight portion, Radix Rhodiolae 17 weight portion, Fructus Hippophae 15 weight portion, Mel 2 weight portion, Radix Rehmanniae Preparata 15 weight portion, the Radix Paeoniae Alba 21 weight portion, Radix Glehniae 15 weight portion, Bulbus Lilii 15 weight portion, Radix Ophiopogonis 17 weight portion, Herba Dendrobii 12 weight portion, Rhizoma Polygonati Odorati 10 weight portion, Herba Ecliptae 8 weight portion, Fructus Ligustri Lucidi 15 weight portion, Fructus Mori 20 weight portion, Semen Sesami Nigrum 19 weight portion, Folium Sennae 15 weight portion, Aloe 15 weight portion, Semen pini koraiensis 15 weight portion, Herba Pyrolae 15 weight portion, Fructus Akebiae 21 weight portion, Radix Angelicae Sinensis 15 weight portion, Herba Cynomorii 17 weight portion, Herba Salsolae Collinae 12 weight portion and Hericium erinaceus (Bull. Ex Fr.) Pers. 17 weight portion.
Its preparation method comprises the following steps:
The first step, Radix Codonopsis, the Radix Astragali and Radix Et Caulis Acanthopanacis Senticosi are mixed in proportion, with the methanol that determining alcohol is 75% as solvent, adopt percolation with the speed slowly percolation of 2ml per minute, collecting percolate, concentrating under reduced pressure also dries, it is thus achieved that dry cream, being ground into powder, the quality of affiliated methanol is 4 times of first step mixture quality；
Second step, is mixed in proportion Fructus Jujubae, Radix Rhodiolae, Fructus Hippophae, Radix Rehmanniae Preparata, the Radix Paeoniae Alba, Radix Glehniae, Bulbus Lilii, Radix Ophiopogonis, Herba Dendrobii, Rhizoma Polygonati Odorati, Herba Ecliptae, Fructus Ligustri Lucidi, Fructus Mori, Semen Sesami Nigrum, Folium Sennae, Aloe and Semen pini koraiensis, is ground into powder；
3rd step, adds the distilled water of the powder quality 4 times obtained relative to second step, decocts 3 hours, filters, it is thus achieved that the first filtrate；Filtering residue is added the distilled water relative to its quality 3 times, decocts 1 hour, filter, it is thus achieved that the second filtrate；Merging the first filtrate and the second filtrate, concentrate away the water of 2/3 volume, adding determining alcohol is the ethanol of 90%, makes determining alcohol reach 70%, stands 18 hours, filters, concentrating under reduced pressure, dry, it is thus achieved that dry cream, is ground into powder；
4th step, the powder mixing that the first step and the 3rd step are obtained, add the distilled water relative to powder mixing quality 4 times amount, the Mel of described weight portion, and the sodium benzoate of powder mixing quality 0.015 times, stirring, boil, cooling, filtering, subpackage, namely sterilizing obtains oral liquid.
Embodiment 3 enema
Embodiments provide a kind of pharmaceutical composition for treating puerperal constipation, the parts by weight of its raw medicinal material are: Radix Codonopsis 25 weight portion, the Radix Astragali 10 weight portion, Fructus Jujubae 10 weight portion, Radix Et Caulis Acanthopanacis Senticosi 10 weight portion, Radix Rhodiolae 15 weight portion, Fructus Hippophae 10 weight portion, Mel 1 weight portion, Radix Rehmanniae Preparata 10 weight portion, the Radix Paeoniae Alba 25 weight portion, Radix Glehniae 20 weight portion, Bulbus Lilii 10 weight portion, Radix Ophiopogonis 20 weight portion, Herba Dendrobii 10 weight portion, Rhizoma Polygonati Odorati 5 weight portion, Herba Ecliptae 10 weight portion, Fructus Ligustri Lucidi 10 weight portion, Fructus Mori 15 weight portion, Semen Sesami Nigrum 15 weight portion, Folium Sennae 10 weight portion, Aloe 10 weight portion and Semen pini koraiensis 10 weight portion.
Its preparation method comprises the following steps: all described raw medicinal materials adding the water soaking 50 minutes of 4 times, heated and boiled 35 minutes, filters, filtrate is standby；Filtering residue adds the water of filtering residue 3 times, second time heated and boiled 35 minutes, filters, and filtrate is standby；Filtering residue adds the water of filtering residue 3 times, third time heated and boiled 35 minutes, filters；Three filtrates being combined, heating is concentrated into pasty state medicinal liquid.
Toxicity test
Acute toxicity test: application NIH mice 60, SPF level, male and female half and half, body weight 17～24g, carries out acute toxicity test.Mice is randomly divided into two groups, often group 20, i.e. matched group and administration group, fasting 12 hours before experiment；The tablet dissolved prepared by embodiments of the invention 1 is in water, (concentration is 5.74g crude drug/ml, maximum concentration) gavage, gavage volume is 5ml/kg(and unit dosage form is 28.7 crude drugs/kg), matched group gives normal saline, within one day, is administered 2 times, delivery time 6 hours, Continuous Observation 14 days after administration, and record mice toxic reaction and death toll.Test result indicate that: compare with matched group, after administration, mice has no notable difference, and experiment Continuous Observation 14 days, mouse systemic situation, diet, drinking-water, body weight increase all normal.Tablet LD50 > 28.7 crude drugs/the kg of the Mouse oral gavage present invention, every day, maximum dosage-feeding was 57.4 crude drugs/kg/ day.The Chinese medicine clinical application amount of the present invention be 4.6g crude drug/day/people, adult body weight in 60KG, average dosage is 0.077g crude drug/kg/ day.By weighing machine: 745 times that the dosis tolerata of the Chinese medicine of mice (average weight with 21g) the oral administration gavage present invention is quantity.Therefore the pharmaceutical composition acute toxicity of the present invention is low, clinical drug safety.
Long term toxicity test: by the oral solutions of the embodiment of the present invention 2 to mice by 6.43,15.72 and 36.41g crude drug/kg continuous use 16 weeks (1.0ml/100g body weight, every day 2 times) and drug withdrawal 4 weeks after, result shows: the indexs such as the hair of mice, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat are all had no significant effect by Chinese medicine preparation of the present invention, internal organs naked eyes do not find that difference change and histological indications show, after medication 16 weeks and drug withdrawal 4 weeks, Organs of Mice is all without substantially changing.Illustrate that pharmaceutical composition of the present invention is little to toxicity after mice long-term prescription, react also without difference after drug withdrawal, application safety.
Clinical trial
Case selection: fetch and come from the court's department of obstetrics and gynecology without medical history of haemorrhoids, without puerpera 160 example of serious organic disease, age 25-35 year, it is randomly divided into four groups, often organize 40 examples, respectively embodiment group 1, embodiment group 2, embodiment group 3 and matched group, often group patient is at no significant difference such as age, parity, childbirth options.
Therapeutic Method:
Embodiment group 1: take the tablet of the embodiment of the present invention 1 preparation, every day twice, each 3, take continuously 2-4 days；
Embodiment group 2: take the oral solutions of the embodiment of the present invention 2 preparation, every day twice, each 20ml, take continuously 2-4 days；
Embodiment group 3: use the enema of the embodiment of the present invention 3 preparation, every day 1 time, use 2-4 days continuously；
Matched group: use glycerin, every day 1 time, use 2-4 days continuously.
The standard of curative effect evaluation: cure: in 2 days can normal defecation 1 time, just matter turns profit, unobstructed during solution, treats in latter 7 days without recurrence；Take a turn for the better: in 3 days can normal defecation 1 time, just matter turns profit, and defecation owes smooth, treats in latter 7 days without recurrence；Invalid: after treating 4 days symptom still without improve, though or take a favorable turn but treat in latter 7 days recur；Wherein, effective percentage is cure rate and improvement rate sum.
Therapeutic outcome:
Referring to table 1 it can be seen that adopt the medicine composite for curing puerperal constipation of the present invention, relative to Chinese patent medicine on therapeutic effect, have and be markedly improved.
Table 1 each experimental group therapeutic effect synopsis example
Group Sum Recovery from illness Take a turn for the better Invalid Effective percentage
Embodiment group 1 40 31 8 1 97.5%
Embodiment group 2 40 35 5 0 100%
Embodiment group 3 40 30 8 2 95%
Matched group 40 17 13 10 75%
According to the clinical statistics in above table it can be seen that pharmaceutical composition provided by the invention have rapid-action, effective percentage is high, determined curative effect, safety is high, the advantage that has no side effect.
Model case: Wang, 28 years old, cesarean, inject antibiotics, caused that intestinal flora production environment changes, and puerperal does not get enough athletic exercise, cause constipation, use the oral solutions of the embodiment of the present invention 2 to treat, every day twice, each 20ml, fully recover after taking continuously 2 days, follow up a case by regular visits to 7 days and do not recur, completely can normal defecation, just matter turns profit, unobstructed during solution.
The foregoing is only presently preferred embodiments of the present invention, not in order to limit the present invention, all within the spirit and principles in the present invention, any amendment of making, equivalent replacement, improvement etc., should be included within protection scope of the present invention.

Claims (6)

1. for treating the medicine of puerperal constipation, it is characterized in that, described medicine includes following raw medicinal material: Radix Codonopsis, the Radix Astragali, Fructus Jujubae, Radix Et Caulis Acanthopanacis Senticosi, Radix Rhodiolae, Fructus Hippophae, Mel, Radix Rehmanniae Preparata, the Radix Paeoniae Alba, Radix Glehniae, Bulbus Lilii, Radix Ophiopogonis, Herba Dendrobii, Rhizoma Polygonati Odorati, Herba Ecliptae, Fructus Ligustri Lucidi, Fructus Mori, Semen Sesami Nigrum, Folium Sennae, Aloe, Semen pini koraiensis, Herba Pyrolae, Fructus Akebiae, Radix Angelicae Sinensis, Herba Cynomorii, Herba Salsolae Collinae and Hericium erinaceus (Bull. Ex Fr.) Pers..
2. the medicine for treating puerperal constipation according to claim 1, it is characterized in that, in described medicine, the parts by weight of each raw medicinal material are: Radix Codonopsis 15-25 weight portion, Radix Astragali 10-20 weight portion, Fructus Jujubae 10-25 weight portion, Radix Et Caulis Acanthopanacis Senticosi 10-20 weight portion, Radix Rhodiolae 15-20 weight portion, Fructus Hippophae 10-20 weight portion, Mel 1-5 weight portion, Radix Rehmanniae Preparata 10-20 weight portion, Radix Paeoniae Alba 15-25 weight portion, Radix Glehniae 10-20 weight portion, Bulbus Lilii 10-20 weight portion, Radix Ophiopogonis 15-20 weight portion, Herba Dendrobii 10-15 weight portion, Rhizoma Polygonati Odorati 5-15 weight portion, Herba Ecliptae 5-10 weight portion, Fructus Ligustri Lucidi 10-20 weight portion, Fructus Mori 15-25 weight portion, Semen Sesami Nigrum 15-25 weight portion, Folium Sennae 10-20 weight portion, Aloe 10-20 weight portion, Semen pini koraiensis 10-20 weight portion, Herba Pyrolae 10-20 weight portion, Fructus Akebiae 15-25 weight portion, Radix Angelicae Sinensis 10-20 weight portion, Herba Cynomorii 15-20 weight portion, Herba Salsolae Collinae 10-15 weight portion and Hericium erinaceus (Bull. Ex Fr.) Pers. 10-25 weight portion.
3. the medicine for treating puerperal constipation according to claim 1 and 2, it is characterized in that, in described medicine, the parts by weight of each raw medicinal material are: Radix Codonopsis 19 weight portion, the Radix Astragali 15 weight portion, Fructus Jujubae 17 weight portion, Radix Et Caulis Acanthopanacis Senticosi 15 weight portion, Radix Rhodiolae 17 weight portion, Fructus Hippophae 15 weight portion, Mel 2 weight portion, Radix Rehmanniae Preparata 15 weight portion, the Radix Paeoniae Alba 21 weight portion, Radix Glehniae 15 weight portion, Bulbus Lilii 15 weight portion, Radix Ophiopogonis 17 weight portion, Herba Dendrobii 12 weight portion, Rhizoma Polygonati Odorati 10 weight portion, Herba Ecliptae 8 weight portion, Fructus Ligustri Lucidi 15 weight portion, Fructus Mori 20 weight portion, Semen Sesami Nigrum 19 weight portion, Folium Sennae 15 weight portion, Aloe 15 weight portion, Semen pini koraiensis 15 weight portion, Herba Pyrolae 15 weight portion, Fructus Akebiae 21 weight portion, Radix Angelicae Sinensis 15 weight portion, Herba Cynomorii 17 weight portion, Herba Salsolae Collinae 12 weight portion and Hericium erinaceus (Bull. Ex Fr.) Pers. 17 weight portion.
4. the medicine for treating puerperal constipation as described in any one of claim 1-3, it is characterised in that the dosage form of described pharmaceutical composition is tablet, and its preparation method comprises the following steps:
The first step, is mixed in proportion each for described Chinese medicine raw medicinal material, adds the ethanol that determining alcohol is 85%～90% relative to mixture quality 4～5 times, is heated to reflux 2～4 hours, extracts, and filters and obtains the first extracting solution；Filter the medicinal residues obtained and add the ethanol that determining alcohol is 90%～95% relative to described medicinal residues quality 2～3 times, be heated to reflux 1～3 hour, extract, filter and obtain the second extracting solution；First extracting solution and the second extracting solution being merged, concentrating under reduced pressure removes alcohol solvent, dry, it is thus achieved that dry cream；
Second step, is placed in super micron mill by the dry cream that the first step obtains and pulverizes 2～3 hours, pulverizes, sieves, it is thus achieved that the micropowders of 300 order～400 orders；
3rd step, the micropowders that second step is obtained, add relative to the microcrystalline Cellulose of its quality 0.1～0.3 times, 0.15～0.3 times of lactose, the starch of 0.2～0.35 times, sieve, mix homogeneously, granulate, dry, add relative to 0.025～0.04 times of magnesium stearate of micropowders quality, granulate, tabletting, makes.
5. the medicine for treating puerperal constipation as described in any one of claim 1-3, it is characterised in that the dosage form of described pharmaceutical composition is oral solutions, and its preparation method comprises the following steps:
The first step, Radix Codonopsis, the Radix Astragali and Radix Et Caulis Acanthopanacis Senticosi are mixed in proportion, with the methanol that determining alcohol is 70%～80% as solvent, adopt percolation with the speed slowly percolation of 1～3ml per minute, collecting percolate, concentrating under reduced pressure also dries, it is thus achieved that dry cream, being ground into powder, the quality of affiliated methanol is 3～5 times of first step mixture quality；
Second step, is mixed in proportion Fructus Jujubae, Radix Rhodiolae, Fructus Hippophae, Radix Rehmanniae Preparata, the Radix Paeoniae Alba, Radix Glehniae, Bulbus Lilii, Radix Ophiopogonis, Herba Dendrobii, Rhizoma Polygonati Odorati, Herba Ecliptae, Fructus Ligustri Lucidi, Fructus Mori, Semen Sesami Nigrum, Folium Sennae, Aloe and Semen pini koraiensis, is ground into powder；
3rd step, adds the distilled water of the powder quality 3～6 times obtained relative to second step, decocts 2～4 hours, filters, it is thus achieved that the first filtrate；Filtering residue is added the distilled water relative to its quality 2～4 times, decocts 1～2 hour, filter, it is thus achieved that the second filtrate；Merging the first filtrate and the second filtrate, concentrate away the water of 2/3～3/4 volume, adding determining alcohol is the ethanol of 90～95%, makes determining alcohol reach 70%～80%, stands 12～24 hours, filters, concentrating under reduced pressure, dry, it is thus achieved that dry cream, is ground into powder；
4th step, the powder mixing that the first step and the 3rd step are obtained, add the distilled water relative to powder mixing quality 3～5 times amount, the Mel of described weight portion, and the sodium benzoate of powder mixing quality 0.01～0.02 times, stirring, boil, cooling, filtering, subpackage, namely sterilizing obtains oral liquid.
6. the medicine for treating puerperal constipation as described in any one of claim 1-5, it is characterized in that, the dosage form of described pharmaceutical composition is enema, its preparation method comprises the following steps: all described raw medicinal materials add the water soaking 30 minutes to 1 hour of 2-5 times, heated and boiled 30～40 minutes, filtering, filtrate is standby；Filtering residue adds the water of filtering residue 2-4 times, second time heated and boiled 30～40 minutes, filters, and filtrate is standby；Filtering residue adds the water of filtering residue 2-4 times, third time heated and boiled 30～40 minutes, filters；Three filtrates being combined, heating is concentrated into pasty state medicinal liquid.
CN201610231143.2A 2014-05-05 2014-05-05 Medicine for treating postnatal constipation and preparation method of medicine Withdrawn CN105709071A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110151740A (en) * 2019-07-09 2019-08-23 遵义医科大学 Bibenzyl compound promotees the application in enterogastric peristalsis drug in preparation

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102178769A (en) * 2011-05-02 2011-09-14 许从玉 Medical composition for preventing or treating postpartum constipation of puerpera

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102178769A (en) * 2011-05-02 2011-09-14 许从玉 Medical composition for preventing or treating postpartum constipation of puerpera

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110151740A (en) * 2019-07-09 2019-08-23 遵义医科大学 Bibenzyl compound promotees the application in enterogastric peristalsis drug in preparation
CN110151740B (en) * 2019-07-09 2022-01-25 遵义医科大学 Application of bibenzyl compound in preparation of medicine for promoting gastrointestinal peristalsis

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