CN105595336A - Preparation method of radix ginseng rubra and fructus lycii cell-wall breaking ultra-fine powder - Google Patents
Preparation method of radix ginseng rubra and fructus lycii cell-wall breaking ultra-fine powder Download PDFInfo
- Publication number
- CN105595336A CN105595336A CN201610000596.4A CN201610000596A CN105595336A CN 105595336 A CN105595336 A CN 105595336A CN 201610000596 A CN201610000596 A CN 201610000596A CN 105595336 A CN105595336 A CN 105595336A
- Authority
- CN
- China
- Prior art keywords
- powder
- red ginseng
- korean red
- breaking
- cell
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000843 powder Substances 0.000 title claims abstract description 97
- 235000008434 ginseng Nutrition 0.000 title claims abstract description 55
- 235000003140 Panax quinquefolius Nutrition 0.000 title claims abstract description 50
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 title claims abstract description 49
- 241000208340 Araliaceae Species 0.000 title claims abstract description 12
- 238000002360 preparation method Methods 0.000 title claims abstract description 10
- 210000002421 cell wall Anatomy 0.000 title abstract description 14
- 238000000034 method Methods 0.000 claims abstract description 11
- 108091005804 Peptidases Proteins 0.000 claims abstract description 5
- 239000004365 Protease Substances 0.000 claims abstract description 5
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 claims abstract description 5
- 235000002789 Panax ginseng Nutrition 0.000 claims description 113
- 235000013399 edible fruits Nutrition 0.000 claims description 40
- 244000241872 Lycium chinense Species 0.000 claims description 38
- 235000015468 Lycium chinense Nutrition 0.000 claims description 38
- 240000001811 Dioscorea oppositifolia Species 0.000 claims description 29
- 235000002722 Dioscorea batatas Nutrition 0.000 claims description 28
- 235000006536 Dioscorea esculenta Nutrition 0.000 claims description 28
- 235000003416 Dioscorea oppositifolia Nutrition 0.000 claims description 28
- 239000011265 semifinished product Substances 0.000 claims description 24
- 239000000203 mixture Substances 0.000 claims description 18
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 17
- 239000002245 particle Substances 0.000 claims description 16
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 11
- 235000002791 Panax Nutrition 0.000 claims description 8
- 241000208343 Panax Species 0.000 claims description 8
- 239000012141 concentrate Substances 0.000 claims description 8
- 238000007599 discharging Methods 0.000 claims description 8
- 238000001035 drying Methods 0.000 claims description 8
- 239000011521 glass Substances 0.000 claims description 8
- 238000003801 milling Methods 0.000 claims description 8
- 238000000227 grinding Methods 0.000 claims description 7
- 238000010298 pulverizing process Methods 0.000 claims description 6
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 5
- 238000004806 packaging method and process Methods 0.000 claims description 5
- 238000010025 steaming Methods 0.000 claims description 5
- 238000001816 cooling Methods 0.000 claims description 4
- 239000008103 glucose Substances 0.000 claims description 4
- 239000008187 granular material Substances 0.000 claims description 4
- 239000002994 raw material Substances 0.000 claims description 4
- 239000011122 softwood Substances 0.000 claims description 4
- 235000020985 whole grains Nutrition 0.000 claims description 4
- 230000000694 effects Effects 0.000 abstract description 26
- 235000013305 food Nutrition 0.000 abstract description 22
- 239000008280 blood Substances 0.000 abstract description 9
- 210000004369 blood Anatomy 0.000 abstract description 9
- 230000036039 immunity Effects 0.000 abstract description 8
- 206010028980 Neoplasm Diseases 0.000 abstract description 5
- 201000011510 cancer Diseases 0.000 abstract description 5
- 102000016943 Muramidase Human genes 0.000 abstract description 3
- 108010014251 Muramidase Proteins 0.000 abstract description 3
- 108010062010 N-Acetylmuramoyl-L-alanine Amidase Proteins 0.000 abstract description 3
- 235000010335 lysozyme Nutrition 0.000 abstract description 3
- 239000004325 lysozyme Substances 0.000 abstract description 3
- 229960000274 lysozyme Drugs 0.000 abstract description 3
- 238000012827 research and development Methods 0.000 abstract description 2
- 244000281702 Dioscorea villosa Species 0.000 abstract 2
- 238000007908 dry granulation Methods 0.000 abstract 1
- 238000000855 fermentation Methods 0.000 abstract 1
- 230000004151 fermentation Effects 0.000 abstract 1
- 230000003647 oxidation Effects 0.000 abstract 1
- 238000007254 oxidation reaction Methods 0.000 abstract 1
- 238000005550 wet granulation Methods 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 description 50
- 240000004371 Panax ginseng Species 0.000 description 44
- 239000003814 drug Substances 0.000 description 40
- 230000012010 growth Effects 0.000 description 12
- 238000005516 engineering process Methods 0.000 description 11
- 239000000463 material Substances 0.000 description 11
- 230000001093 anti-cancer Effects 0.000 description 10
- 210000000952 spleen Anatomy 0.000 description 9
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 8
- 244000241838 Lycium barbarum Species 0.000 description 8
- 235000015459 Lycium barbarum Nutrition 0.000 description 8
- 230000009286 beneficial effect Effects 0.000 description 8
- 230000036541 health Effects 0.000 description 8
- 239000000047 product Substances 0.000 description 8
- 201000010099 disease Diseases 0.000 description 7
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 7
- 230000006870 function Effects 0.000 description 6
- 210000003734 kidney Anatomy 0.000 description 6
- 210000004185 liver Anatomy 0.000 description 6
- 238000011161 development Methods 0.000 description 5
- 230000018109 developmental process Effects 0.000 description 5
- 206010012601 diabetes mellitus Diseases 0.000 description 5
- 229940079593 drug Drugs 0.000 description 5
- 210000004072 lung Anatomy 0.000 description 5
- 235000016709 nutrition Nutrition 0.000 description 5
- 230000005180 public health Effects 0.000 description 5
- 230000035922 thirst Effects 0.000 description 5
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 4
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 4
- 150000001413 amino acids Chemical class 0.000 description 4
- 230000003712 anti-aging effect Effects 0.000 description 4
- 230000008901 benefit Effects 0.000 description 4
- 235000009508 confectionery Nutrition 0.000 description 4
- 239000000470 constituent Substances 0.000 description 4
- 230000035622 drinking Effects 0.000 description 4
- 230000000857 drug effect Effects 0.000 description 4
- 235000008216 herbs Nutrition 0.000 description 4
- 239000004615 ingredient Substances 0.000 description 4
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 4
- 230000010354 integration Effects 0.000 description 4
- 229910052742 iron Inorganic materials 0.000 description 4
- 238000002372 labelling Methods 0.000 description 4
- 239000001397 quillaja saponaria molina bark Substances 0.000 description 4
- 229930182490 saponin Natural products 0.000 description 4
- 150000007949 saponins Chemical class 0.000 description 4
- 208000024891 symptom Diseases 0.000 description 4
- 206010011224 Cough Diseases 0.000 description 3
- 238000010521 absorption reaction Methods 0.000 description 3
- 208000007502 anemia Diseases 0.000 description 3
- 239000003963 antioxidant agent Substances 0.000 description 3
- 230000003078 antioxidant effect Effects 0.000 description 3
- 235000006708 antioxidants Nutrition 0.000 description 3
- 230000007812 deficiency Effects 0.000 description 3
- 235000004879 dioscorea Nutrition 0.000 description 3
- 230000002496 gastric effect Effects 0.000 description 3
- 229910052500 inorganic mineral Inorganic materials 0.000 description 3
- 238000007726 management method Methods 0.000 description 3
- 239000011707 mineral Substances 0.000 description 3
- 235000010755 mineral Nutrition 0.000 description 3
- 230000002265 prevention Effects 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- 238000010791 quenching Methods 0.000 description 3
- 238000011160 research Methods 0.000 description 3
- 239000011435 rock Substances 0.000 description 3
- 210000002784 stomach Anatomy 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 2
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 description 2
- 241000196324 Embryophyta Species 0.000 description 2
- 102000004877 Insulin Human genes 0.000 description 2
- 108090001061 Insulin Proteins 0.000 description 2
- 241001106041 Lycium Species 0.000 description 2
- MWUXSHHQAYIFBG-UHFFFAOYSA-N Nitric oxide Chemical compound O=[N] MWUXSHHQAYIFBG-UHFFFAOYSA-N 0.000 description 2
- 229930003268 Vitamin C Natural products 0.000 description 2
- 229930003427 Vitamin E Natural products 0.000 description 2
- POJWUDADGALRAB-UHFFFAOYSA-N allantoin Chemical compound NC(=O)NC1NC(=O)NC1=O POJWUDADGALRAB-UHFFFAOYSA-N 0.000 description 2
- 206010003549 asthenia Diseases 0.000 description 2
- 230000003796 beauty Effects 0.000 description 2
- 230000033228 biological regulation Effects 0.000 description 2
- 210000000988 bone and bone Anatomy 0.000 description 2
- 239000011575 calcium Substances 0.000 description 2
- 229910052791 calcium Inorganic materials 0.000 description 2
- 230000007969 cellular immunity Effects 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- 230000002708 enhancing effect Effects 0.000 description 2
- 230000003203 everyday effect Effects 0.000 description 2
- 230000004438 eyesight Effects 0.000 description 2
- 239000004744 fabric Substances 0.000 description 2
- 238000001914 filtration Methods 0.000 description 2
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 2
- 235000013402 health food Nutrition 0.000 description 2
- 201000001881 impotence Diseases 0.000 description 2
- 229940125396 insulin Drugs 0.000 description 2
- 230000007774 longterm Effects 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 230000005906 menstruation Effects 0.000 description 2
- 238000012545 processing Methods 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 230000003014 reinforcing effect Effects 0.000 description 2
- 239000000523 sample Substances 0.000 description 2
- 230000001568 sexual effect Effects 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- 238000005728 strengthening Methods 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 230000002936 tranquilizing effect Effects 0.000 description 2
- 235000019154 vitamin C Nutrition 0.000 description 2
- 239000011718 vitamin C Substances 0.000 description 2
- 235000019165 vitamin E Nutrition 0.000 description 2
- 239000011709 vitamin E Substances 0.000 description 2
- 229940046009 vitamin E Drugs 0.000 description 2
- 235000014101 wine Nutrition 0.000 description 2
- 206010049865 Achromotrichia acquired Diseases 0.000 description 1
- POJWUDADGALRAB-PVQJCKRUSA-N Allantoin Natural products NC(=O)N[C@@H]1NC(=O)NC1=O POJWUDADGALRAB-PVQJCKRUSA-N 0.000 description 1
- 102000040350 B family Human genes 0.000 description 1
- 108091072128 B family Proteins 0.000 description 1
- KWIUHFFTVRNATP-UHFFFAOYSA-N Betaine Natural products C[N+](C)(C)CC([O-])=O KWIUHFFTVRNATP-UHFFFAOYSA-N 0.000 description 1
- 201000006474 Brain Ischemia Diseases 0.000 description 1
- 206010008120 Cerebral ischaemia Diseases 0.000 description 1
- 208000010445 Chilblains Diseases 0.000 description 1
- 206010008528 Chillblains Diseases 0.000 description 1
- 235000019750 Crude protein Nutrition 0.000 description 1
- JPVYNHNXODAKFH-UHFFFAOYSA-N Cu2+ Chemical compound [Cu+2] JPVYNHNXODAKFH-UHFFFAOYSA-N 0.000 description 1
- AUNGANRZJHBGPY-UHFFFAOYSA-N D-Lyxoflavin Natural products OCC(O)C(O)C(O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-UHFFFAOYSA-N 0.000 description 1
- 206010012735 Diarrhoea Diseases 0.000 description 1
- 206010013082 Discomfort Diseases 0.000 description 1
- 206010013786 Dry skin Diseases 0.000 description 1
- 102000002322 Egg Proteins Human genes 0.000 description 1
- 108010000912 Egg Proteins Proteins 0.000 description 1
- 208000010228 Erectile Dysfunction Diseases 0.000 description 1
- 208000036119 Frailty Diseases 0.000 description 1
- 208000007882 Gastritis Diseases 0.000 description 1
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 1
- 206010061598 Immunodeficiency Diseases 0.000 description 1
- 206010062717 Increased upper airway secretion Diseases 0.000 description 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
- 208000002720 Malnutrition Diseases 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 229930192392 Mitomycin Natural products 0.000 description 1
- 206010028034 Mouth ulceration Diseases 0.000 description 1
- NWIBSHFKIJFRCO-WUDYKRTCSA-N Mytomycin Chemical compound C1N2C(C(C(C)=C(N)C3=O)=O)=C3[C@@H](COC(N)=O)[C@@]2(OC)[C@@H]2[C@H]1N2 NWIBSHFKIJFRCO-WUDYKRTCSA-N 0.000 description 1
- KWIUHFFTVRNATP-UHFFFAOYSA-O N,N,N-trimethylglycinium Chemical compound C[N+](C)(C)CC(O)=O KWIUHFFTVRNATP-UHFFFAOYSA-O 0.000 description 1
- 208000006595 Necrotizing Ulcerative Gingivitis Diseases 0.000 description 1
- 208000001132 Osteoporosis Diseases 0.000 description 1
- 240000007930 Oxalis acetosella Species 0.000 description 1
- 235000008098 Oxalis acetosella Nutrition 0.000 description 1
- 240000005373 Panax quinquefolius Species 0.000 description 1
- 235000010240 Paullinia pinnata Nutrition 0.000 description 1
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 1
- 206010037660 Pyrexia Diseases 0.000 description 1
- AUNGANRZJHBGPY-SCRDCRAPSA-N Riboflavin Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-SCRDCRAPSA-N 0.000 description 1
- 208000034189 Sclerosis Diseases 0.000 description 1
- BUGBHKTXTAQXES-UHFFFAOYSA-N Selenium Chemical compound [Se] BUGBHKTXTAQXES-UHFFFAOYSA-N 0.000 description 1
- 229930003451 Vitamin B1 Natural products 0.000 description 1
- 229930003471 Vitamin B2 Natural products 0.000 description 1
- 229930003316 Vitamin D Natural products 0.000 description 1
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 241000607479 Yersinia pestis Species 0.000 description 1
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 1
- LPQOADBMXVRBNX-UHFFFAOYSA-N ac1ldcw0 Chemical compound Cl.C1CN(C)CCN1C1=C(F)C=C2C(=O)C(C(O)=O)=CN3CCSC1=C32 LPQOADBMXVRBNX-UHFFFAOYSA-N 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 125000001931 aliphatic group Chemical group 0.000 description 1
- 229960000458 allantoin Drugs 0.000 description 1
- 230000036592 analgesia Effects 0.000 description 1
- 230000002929 anti-fatigue Effects 0.000 description 1
- 210000001367 artery Anatomy 0.000 description 1
- 229960003237 betaine Drugs 0.000 description 1
- 235000013361 beverage Nutrition 0.000 description 1
- 210000000941 bile Anatomy 0.000 description 1
- 230000000975 bioactive effect Effects 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 230000036772 blood pressure Effects 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 210000004556 brain Anatomy 0.000 description 1
- 210000000481 breast Anatomy 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 210000000170 cell membrane Anatomy 0.000 description 1
- 206010008118 cerebral infarction Diseases 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 238000002512 chemotherapy Methods 0.000 description 1
- 230000006835 compression Effects 0.000 description 1
- 238000007906 compression Methods 0.000 description 1
- 210000002808 connective tissue Anatomy 0.000 description 1
- 229910001431 copper ion Inorganic materials 0.000 description 1
- 230000002354 daily effect Effects 0.000 description 1
- 230000008021 deposition Effects 0.000 description 1
- 230000029087 digestion Effects 0.000 description 1
- 208000017574 dry cough Diseases 0.000 description 1
- 230000037336 dry skin Effects 0.000 description 1
- 230000004064 dysfunction Effects 0.000 description 1
- 201000006549 dyspepsia Diseases 0.000 description 1
- 230000002526 effect on cardiovascular system Effects 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 235000020776 essential amino acid Nutrition 0.000 description 1
- 239000003797 essential amino acid Substances 0.000 description 1
- 239000012259 ether extract Substances 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 235000013373 food additive Nutrition 0.000 description 1
- 239000002778 food additive Substances 0.000 description 1
- 235000012055 fruits and vegetables Nutrition 0.000 description 1
- 235000013376 functional food Nutrition 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 235000001497 healthy food Nutrition 0.000 description 1
- 208000006454 hepatitis Diseases 0.000 description 1
- 231100000283 hepatitis Toxicity 0.000 description 1
- 241000411851 herbal medicine Species 0.000 description 1
- 208000013403 hyperactivity Diseases 0.000 description 1
- 201000001421 hyperglycemia Diseases 0.000 description 1
- 230000001077 hypotensive effect Effects 0.000 description 1
- 230000007688 immunotoxicity Effects 0.000 description 1
- 231100000386 immunotoxicity Toxicity 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 238000009776 industrial production Methods 0.000 description 1
- 208000000509 infertility Diseases 0.000 description 1
- 230000036512 infertility Effects 0.000 description 1
- 231100000535 infertility Toxicity 0.000 description 1
- 230000008595 infiltration Effects 0.000 description 1
- 238000001764 infiltration Methods 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 239000002198 insoluble material Substances 0.000 description 1
- 230000003914 insulin secretion Effects 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 210000000936 intestine Anatomy 0.000 description 1
- 230000003834 intracellular effect Effects 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 210000003127 knee Anatomy 0.000 description 1
- 230000003859 lipid peroxidation Effects 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 238000003754 machining Methods 0.000 description 1
- 239000011777 magnesium Substances 0.000 description 1
- 229910052749 magnesium Inorganic materials 0.000 description 1
- 230000001071 malnutrition Effects 0.000 description 1
- 235000000824 malnutrition Nutrition 0.000 description 1
- WPBNNNQJVZRUHP-UHFFFAOYSA-L manganese(2+);methyl n-[[2-(methoxycarbonylcarbamothioylamino)phenyl]carbamothioyl]carbamate;n-[2-(sulfidocarbothioylamino)ethyl]carbamodithioate Chemical compound [Mn+2].[S-]C(=S)NCCNC([S-])=S.COC(=O)NC(=S)NC1=CC=CC=C1NC(=S)NC(=O)OC WPBNNNQJVZRUHP-UHFFFAOYSA-L 0.000 description 1
- 235000013372 meat Nutrition 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 230000009245 menopause Effects 0.000 description 1
- 230000003340 mental effect Effects 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- 229960004857 mitomycin Drugs 0.000 description 1
- 210000004877 mucosa Anatomy 0.000 description 1
- 230000035772 mutation Effects 0.000 description 1
- 210000002569 neuron Anatomy 0.000 description 1
- 230000035764 nutrition Effects 0.000 description 1
- 208000015380 nutritional deficiency disease Diseases 0.000 description 1
- 230000008520 organization Effects 0.000 description 1
- 210000004681 ovum Anatomy 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 230000036407 pain Effects 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 208000026435 phlegm Diseases 0.000 description 1
- 229910052698 phosphorus Inorganic materials 0.000 description 1
- 239000011574 phosphorus Substances 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 208000008128 pulmonary tuberculosis Diseases 0.000 description 1
- 230000000171 quenching effect Effects 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 238000007670 refining Methods 0.000 description 1
- 230000008929 regeneration Effects 0.000 description 1
- 238000011069 regeneration method Methods 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 229960002477 riboflavin Drugs 0.000 description 1
- 210000003296 saliva Anatomy 0.000 description 1
- 239000013049 sediment Substances 0.000 description 1
- 229910052711 selenium Inorganic materials 0.000 description 1
- 239000011669 selenium Substances 0.000 description 1
- 230000035946 sexual desire Effects 0.000 description 1
- 239000002893 slag Substances 0.000 description 1
- 239000000344 soap Substances 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 229910052717 sulfur Inorganic materials 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 229960003495 thiamine Drugs 0.000 description 1
- DPJRMOMPQZCRJU-UHFFFAOYSA-M thiamine hydrochloride Chemical compound Cl.[Cl-].CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N DPJRMOMPQZCRJU-UHFFFAOYSA-M 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 235000015961 tonic Nutrition 0.000 description 1
- 230000001256 tonic effect Effects 0.000 description 1
- 229960000716 tonics Drugs 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 239000003440 toxic substance Substances 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 239000011573 trace mineral Substances 0.000 description 1
- 235000013619 trace mineral Nutrition 0.000 description 1
- 230000001228 trophic effect Effects 0.000 description 1
- 230000004614 tumor growth Effects 0.000 description 1
- 201000008587 ulcerative stomatitis Diseases 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
- 210000003556 vascular endothelial cell Anatomy 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 235000010374 vitamin B1 Nutrition 0.000 description 1
- 239000011691 vitamin B1 Substances 0.000 description 1
- 235000019164 vitamin B2 Nutrition 0.000 description 1
- 239000011716 vitamin B2 Substances 0.000 description 1
- 235000019166 vitamin D Nutrition 0.000 description 1
- 239000011710 vitamin D Substances 0.000 description 1
- 150000003710 vitamin D derivatives Chemical class 0.000 description 1
- 229940046008 vitamin d Drugs 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
- 239000011800 void material Substances 0.000 description 1
- 235000020097 white wine Nutrition 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A40/00—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production
- Y02A40/90—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production in food processing or handling, e.g. food conservation
Abstract
The invention belongs to the technical field of food and health-care food research and development, and relates to a preparation method of radix ginseng rubra and fructus lycii cell-wall breaking ultra-fine powder. The method comprises the steps that fresh ginseng is processed into radix ginseng rubra, the radix ginseng rubra is smashed into powder through an ordinary pulverizer, the powder is smashed into cell-wall breaking ultra-fine powder through an air-current mill or a vibration mill, lysozyme beta-1.3-glucanase or protease is added for fermentation, and fermented radix ginseng rubra cell-wall breaking ultra-fine powder is obtained; fructus lycii and common yam rhizomes are mixed and smashed into cell-wall breaking ultra-fine powder; the radix ginseng rubra cell-wall breaking ultra-fine powder or the fermented radix ginseng rubra cell-wall breaking ultra-fine powder is mixed with the fructus lycii and common yam rhizome cell-wall breaking ultra-fine powder to be uniform, dry granulation or wet granulation is conducted, and the radix ginseng rubra and fructus lycii cell-wall breaking ultra-fine powder is obtained. The radix ginseng rubra and fructus lycii cell-wall breaking ultra-fine powder has the effects of tonifying qi, enriching essence, nourishing blood, resisting oxidation, cancer and senility and improving memory and immunity.
Description
Technical field
Food and health food research and development technical field under the present invention. The present invention relates to a kind of Korean red ginseng fruit of Chinese wolfberryThe preparation method of breaking-wall cell Ultramicro-powder. Product of the present invention has tonifying Qi, beneficial intensive culture blood, anti-oxidant, anticancer, anti-ageing, raisingThe function of memory, raising immunity.
Background technology
Ginseng
Ginseng is the root and rhizome of Araliaceae Araliaeeae perennial plant PanaxginsengC.A.Meyer.. Ginseng quiltBe called " king of Chinese medicine ", have the good reputation of " national treasure ". Ginseng medical value is very high, the strengthening by means of tonics effect to human body and to multipleThe prevention effect of disease is very remarkable, in motherland's traditional Chinese medicine, have " ginseng taste is sweet, reinforces vital energy, tonifying spleen, beneficial gas, the intelligence development of allaying excitement,Slake thirst and help produce saliva, menstruation regulating nourishing the stomach, promote longevity " effect, research in recent years achievement shows: ginseng have anti-oxidant, anticancer, anti-ageing,Improve memory, improve the functions such as immunity.
Ginseng belongs to traditional Chinese medicine, for Chinese medicine and healthy food material. 2009, Codex Alimentary Commission(CAC) " ginseng food " international standard has been approved in the 32nd conference, and regulation artificial growth ginseng can be used for food. China's JiLin Sheng is ginseng main producing region, and the culture of ginseng gross area is basicly stable 3,500 ten thousand square metres of left and right in recent years, year finished product ginseng4000 tons of left and right, ginseng output has accounted for 80% of the whole nation, accounts for 70% left and right of global output.
For developing the ginseng resource of China's abundant, the suggestion of government of Jilin Province is included ginseng in bread and cheese management. LuckyWoods Department of Public Health of Shanxi Province organizes scientific research institution to carry out the long-term edible safety appraisal of artificial growth ginseng, and result of study shows,In rated condition and dosage range, artificial growth ginseng is to animal free of toxic effects, and healthy population eats artificial growth ginsengSafe. To this, my portion carries out together with multidisciplinary experts of Departmental organization such as the Ministry of Agriculture, Administration of Food and Drug, Department of HealthThe relevant demonstration of artificial growth ginseng.
Year, ginseng " integration of drinking and medicinal herbs " pilot that government of Jilin Province carries out, and promulgated new " Ginseng In Jilin Province Management OfficeMethod ", wherein clearly specify, " ginseng can be for food, medicine, health food, food additives and daily chemicals, techniqueThe production of the products such as product ", the ginseng here refers to artificial growth ginseng, this way came into effect on March 1st, 2011.
Year, the Ministry of Public Health receives after the application of artificial growth ginseng as new resource food, through organize medical science, Chinese medicine, agricultural,Security, activity and nutritional labeling, the discomforts of aspect expert to artificial growth ginseng such as food, nutrition, toxicity, pharmacology and techniqueAudit the aspects such as pleasant group, thinks that healthy population is safe according to the edible artificial growth ginseng of edible limitation. 2012 3Month, it is that new resource food is solicited relevant department's suggestion that the Ministry of Public Health just ratifies artificial growth ginseng, openly solicits meaning to society simultaneouslySee.
According to artificial growth ginseng edible safety assessment result, Ministry of Public Health's bulletin 2012 No. 17, according to " middle ChinesePeople republic the law of food safety " and the regulation of " new resource food management method ", Ministry of Public Health's official approval 5 years and 5 years are with servantThe ginseng that work post is planted is new resource food. This means, following in China, artificial growth ginseng can be with right titles and proper words as foodProduct are edible. This measure is significant, will further promote Chinese ginseng industry development, takes part in international competition better. Due to vastConsumer is the understanding to red ginseng drug effect and health care gradually. Make red ginseng and series of products deeply be subject to consumers in general's welcome, cityField capacity rises year by year. China increases the demand of ginseng, and international demand does not subtract, and following this industrial prospect is wide.
Huan Cui building Korean red ginseng is by the limited public affairs of fresh garden ginsent You Huancui building, the Koryo of originating from Korea S red ginseng biotechnology shareDepartment introduces Korea S's Korean red ginseng processing technology and domestic red ginseng advanced machining technology processes.
Korean red ginseng system is processed through steaming, toasting by the fresh ginseng in the Koryo of originating from Korea S, in processing Korean red ginseng processIn, there is new anticancer active constituent to produce. Korean red ginseng is not cool not warm yet, belongs to warm nature; Though Korean ginseng is warm in nature, benefit property is strong, benefitGas helps fire. Korean ginseng divides again white ginseng and red ginseng, and insufficiency of the spleen hyperactivity of fire person should use white ginseng, because of " raw use gas is cool, micro-bitter tonifying yin "; Insufficiency of the spleen lung is timidPerson should use red ginseng, " ripe in temperature, the sweet yang-tonifying of taste ". On the whole, Korean ginseng is more suitable for the frank people of the old deficiency of vital energy and takes,The strong physique of energy, strengthens immunity.
Effect of Korean red ginseng:
(1) brain healthy: the people that failure of memory and sports coordination ability are declined and be on the drink or contact zones ethanol becomesPoint food, the people of medicine, Korean red ginseng has and improves mental working ability, strengthens memory and improve cerebral ischemia obstacleEffect.
(2) analgesia: some experts are by doing sensing nerve cell test discovery, and Korean ginseng to the various pain symptoms of health allHelpful.
(3) anti-cancer and anticancer: the saponin constituent of Korean red ginseng and non-saponin constituent have the propagation that suppresses multiple cancer cell to liveProperty, also can shift by inhibition cancer cell simultaneously. In addition, Korean red ginseng and anticancer are with taking, and it is anti-that anticancer effect is better than independent useCancer agent (mitomycin). This is that Korean red ginseng and anticancer, with taking, strengthen because cancer cell easily forms tolerance in chemotherapy of tumorsLethality to cancer cell, the side effect that alleviates anticancer.
(4) strengthen immunity: the anticancer that Korean red ginseng extract can recover to have because of taking immunotoxicity (thread splits mouldElement) and the cellular immunity declining reacts, especially ether extract can activate or strengthen cellular immunity, and NKActivity, to improve immunity have very large effect.
(5) control diabetes: Korean red ginseng contains the material that promotes insulin secretion and similar insulin action, Qi ZhongrenGinseng saponin(e can improve hyperglycaemia, effectively controls the generation of diabetes.
(6) strong liver: have antihepatitic activity in Korean ginseng composition, there is removing toxic substances, protection liver and promotion liver regeneration, recoveryEffect. In addition, Korean red ginseng relieves the effect of alcohol, eliminates the effect of being still drank after a night in addition.
(7) regulate blood pressure: Korean red ginseng has hemangiectasis effect, can improve blood circulation, saponin constituent is wherein logicalCross promotion vascular endothelial cell and discharge nitric oxide, can reach hypotensive activity.
(8) antifatigue and resistance to compression: find after deliberation, continue to take Korean red ginseng and can improve locomitivity and alleviate tiredLabor, has very great help to the recovery and the prevention exercise induced anemia that promote player's fatigue accumulation; In addition, Korean red ginseng can also increaseTolerance to adverse environments such as low temperature (5 DEG C, O DEG C ,-10 DEG C) and high temperature (35 DEG C) by force, by entering pressure or environmental changeThe exquisite adjusting of row, improves anti-pressure ability, maintains organism stability.
(9) improve Menopause obstacle: according to investigations, there is the women of climacteric obstacle symptom taking after Korean red ginseng,After having 80% people to admit to take Korean red ginseng, symptom is obviously improved. Expert claims, these women are as adjusted consumption according to symptom,Also can improve curative effect.
(10) improve male sexual disfunction: Korean red ginseng can prevent the male sexual disfunction causing because of pressure. Through facingBed test, erectile dysfunction patient (90 people) takes after Korean red ginseng, all changes to some extent at aspects such as the degree of erection, sexual desire and satisfactionsKind.
(11) anti-oxidant and anti-ageing: Korean red ginseng has and suppresses increasing and the antioxygen of lipid peroxidation of harmful active oxygenChange effect.
Fruit of Chinese wolfberry matrimony vine is the plant of Solanaceae Lycium (Lycium), and fruit claims the fruit of Chinese wolfberry, and frequent species is matrimony vine, and main medicinal kind is lycium barbarum (LyciumbarbarumL.) (LyciumchinenseMiller).
The sweet property of fruit of Chinese wolfberry taste is flat, returns liver, kidney channel. It has nourishing liver and kidney, beneficial intensive culture blood, and the improving eyesight screen that disappears, moistens the lung and relieve the coughEffect. Cure mainly the atrophic debility of bones of suffering from a deficiency of the kidney, impotence and seminal emission, infertility for a long time, senilism early ageing, poliosis, the deficiency of blood is sallow, and postpartum, breast was few, and order is darkNot clear, interior external opculopathy eye, interior heat is quenched one's thirst, the hot hectic fever due to yin of labor, consumptive disease cough, the diseases such as the few phlegm of dry cough. It should be noted that because of matrimony vine energyNourshing Yin and drynsessmoistening prescription, so insufficiency of the spleen just rotten person should not use. The fruit of Chinese wolfberry contains abundant following material: LBP-X, monose, betaine,Aliphatic acid, proteins and peptides, vitamin B1, vitamin B2, vitamin C, 18 seed amino acids (containing 8 kinds of essential amino acids), micro-Secondary element (calcium, zinc, magnesium, iron, manganese, phosphorus etc.). In addition, record carrotene in matrimony vine according to the Chinese composition table of foods of up-to-date publicationContent is significantly higher than fruit and vegetable, also contains the compositions such as vitamin E, vitamin D, phosphatide and selenium.
Pharmaceutical research confirms, the adjustable body's immunity of the fruit of Chinese wolfberry, can effectively suppress tumor growth and cell mutation,Have delay senility, the effect of the aspect such as AFL, adjusting blood fat and blood sugar. Therefore, the fruit of Chinese wolfberry is to diabetes, dyslipidemiaDisease, dysfunction of liver, gastritis etc. have certain therapeutic action. Conventional prescription and herbal cuisine side's treatment anaemia, malnutrition: sun-driedJoin 20 grams, 350 grams of matrimony vines, 100 grams, cultivated land, 400 grams, rock sugar, 1000 grams of white wine. Sun-dried ginseng sheet, matrimony vine are loaded onto with gauze bagTying is for subsequent use. Rock sugar is put into pot, is heated to boil by suitable quantity of water, removes slag while hot for subsequent use while refining to look Huang by filtered through gauze. White winePack in wine jar, the cloth bag that sun-dried ginseng, matrimony vine are housed is put into wine covered and enclosed and soak 10~15 days, stir bubble every day 1 timeTo the greatest extent light to flavour of a drug, take out medicine bag, with fine cloth filtering sediment, add rock sugar, stir evenly, then leave standstill filtration, clear and bright. Every day 10~20 grams, can be strong anti-ageing, tonifying yin blood, black beard and hair, strong waist knee, strong eyesight, activating blood to promote menstruation, be applicable to after being ill body void and anaemia,The malnutritive patients that waits, anosis normal drink, also has the merit building up one's health and prolong one's life.
Chinese yam is the dry rhizome of Dioscoreaceae plant Chinese yam Dioscoreaopposita
" book on Chinese herbal medicine is looked for the truth ": " enter in drugs for nourishing yin and should give birth to use, entering tonifying spleen lung medicine should use by stir-bake to yellowish. " " this genus food, though gas is warm and flat,For the moon of tonifying spleen lung. Can moisten fur, longue meat, taste is sweet double salty, again can kidney-nourishing reinforcing yin essence. "
(1) tonifying middle-Jiao and Qi: iron rod yam is planted trace element because being rich in 18 seed amino acids and more than 10, and other mineral matter, so haveStrengthening the spleen and stomach, tonifying lung kidney, tonifying middle-Jiao and Qi, invigorating the spleen qi-restoratives, the effects such as beneficial essence, beneficial heart and tranquilizing mind of reinforcing the kidney, have in Li Shizhen (1518-1593 A.D.) Compendium of Material MedicaSaying of " all kinds of diseases and ailments are reinforced the kidney, controlled to invigorating the spleen help, taste essence, treats general debility ".
(2) quench one's thirst and promote the production of body fluid: this Chinese yam has effect of the life of quenching one's thirst: Chinese traditional treatment consumptive disease quench one's thirst (diabetes) prescription in often have mountainPrescription taste uses, or share with other medicines, and effect is better.
(3) health care: because fresh Chinese yam is rich in multivitamin, amino acid and mineral matter, can prevent and treat Human Lipid MetabolismExtremely, and artery sclerosis, to safeguarding that insulin normal function also has certain effect, there is enhancing body immunity, beneficial heart and tranquilizing mind,Rather cough Dingchuan, the health-care effect such as delay senility.
(4) beauty treatment: Yuan Dynasty taste expert Li Gao says: " control dry skin and moisten it with this thing. " Li Shizhen (1518-1593 A.D.) is write: " Chinese yam energyProfit fur. " Chinese yam is to nourishes rough skin, and vigorous and graceful beauty treatment has unique curative effect.
(5) iron rod yam special pharmacological function: the copper ion in Chinese yam and connective tissue have very big help to human development,Vascular system disease is had to obvious curative effects, and the calcium in iron rod yam, damages bone, osteoporosis to the injury of the tissues, and loss of tooth has highCurative effect, to pernio, diabetes, hepatitis, children's's diarrhea, enruesis, baby's indigestion, ulcerative stomatitis, pulmonary tuberculosis, womenThe inferior patient of sanitary towel also has good curative effect, with can be clear-headed and clear-sighted, promotes longevity for a long time.
(6) control feed desire: in Chinese yam, be rich in a large amount of protein, B family vitamin, vitamin C, vitamin E, grapeSugar, crude protein amino acid, bile alkaline, allantoin etc.; Wherein important nutritional labeling Chinese yam soap is the elder generation of synthetic estrogenDrive material, nourishment for vitality, strengthen metabolic effect; And the mucilaginous substance of the GL-PP composition containing in fresh tuber, disappearChange ferment etc., can prevent cardiovascular fat deposition, contribute to digestion and the absorption of stomach and intestine.
Breaking-wall cell is a kind of superfine powder process technology, if Chinese medicine adopt usual manner pulverize, its single particle often bySeveral or dozens of forms, and the sporoderm-broken rate of cell is extremely low. Chinese medicine breaking-wall cell ultramicro grinding process technology can be medicinal materialActive ingredient fully discharges. After breaking-wall cell, intracellular moisture content oil content is moved out, and particulate surface is presented half moisteningState, can form stable particle cluster, the traditional Chinese medicine ingredients that each particle cluster comprises same ratio between particle and particle. This grainThe physical arrangement of son group is not with each composition HLB value (hydrophilic, lipophilic balance value), ductility, brokenness, proportion etc. in component on the same groupClose with different interactions and difference. This structure is conducive to absorption and the utilization of human body to Chinese medicine. The fat-soluble enhancing of Chinese medicine,Through adipose membrane, can put forward rapidly the blood concentration in human body easily, reach the object of healing. Adopt cell wall breaking technology, first,Can increase the absorptivity of medicine and food, improve its bioavilability. Chinese medicine is after ultra micro is processed, and medicine can divide preferablyFall apart, be dissolved in gastro-intestinal Fluid, and increase with the contact area of gastrointestinal mucosa, more easily by gastrointestinal absorption, thereby greatly improvedBioavilability. For mineral substance medicinal material, be equivalent to a part for water-insoluble materials, after ultra micro is processed, due to its granularityGreatly reduce, can accelerate its dissolving, infiltration rate in vivo, improve its uptake. Secondly, be conducive to retains biological activityPoint, improve drug effect, be conducive to retain bioactive ingredients and the various nutritional labeling of non-refractory, thereby improve drug effect. Finally,Conservation, is convenient to application. Chinese medicine is after ultramicro grinding, and available smaller dose, obtains original prescription curative effect.
What China was to having " doctor's food homology, integration of drinking and medicinal herbs " says, integration of drinking and medicinal herbs is early on the books in history. " dietotherapy " is health careMarrow in theory. Nowadays people's self health consciousness, day by day strengthening, has had stronger for promoting longevity, remaining youthful foreverHope, this ancient concept of " doctor food homology, integration of drinking and medicinal herbs ", another has been given people and has pursued go back to nature newImplication. Along with China's medical model is changed to prevention, treatment, rehabilitation, health care comprehensive model by simple treatment, can be by certainThe Chinese medicine of a little medicine-food two-purposes is processed into micropowders, makes various functional foods, serves the whole mankind. Applying this technology producesProduct there are six large features: the firstth, after Chinese medicine breaking-wall cell, good absorbability that it has, dissolubility, chemistry are livedThe advantages such as property, biologically active, have fabulous value to human body. The secondth, after Chinese medicine breaking-wall cell, traditional Chinese medicine is existedOn producing, treat, innovate, using, there is revolutionary variation. The 3rd is to have solved Chinese medicine to perplex for a long time related industry developmentA difficult problem---use complicated, time-consuming and inconvenient. Utilize this technology can be made into and exempt to decoct Chinese medicine, easy to use,Reduce again dosage. The 4th is to have reduced the medicament residue in body, can also improve medicine quality, is beneficial to the mankind strongHealth, for these industry product export earnings good condition. The 5th can improve the hygienic quality of Chinese medicine, and Chinese medicine is being carried out carefullyWhen born of the same parents' broken wall ultramicro grinding, the worm's ovum suitable with cell yardstick also can be killed, thereby alleviated the dirt of disease and pest to Chinese medicineDye and infringement, make ultra micro Chinese medicine there is pure natural property, ensured integrality and the security of traditional Chinese medicine ingredients. The 6th is to be beneficial to ringGuarantor, greening and vegetation protection, played great function to the long-term and sustainable development of Chinese Medicine Industry. Cell wall breaking technology can saveAbout Chinese medicine 40% ~ 60%, indivedual Chinese medicine can improve the drug effect of 4 times, and therefore, it is huge that Chinese medicine cell wall breaking technology will make industrial production promoteLarge economic benefit and social benefit. Technique can be widely used in health products, non-staple food, food, medicine, beverage, cosmeticThe industry such as product, herding, market prospects and development space are very wide.
The preparation of Korean red ginseng powder and micron, adopts cell wall breaking technology, impels effective active matter stripping in cell, is easy toAbsorbed by human body, the property of medicine is gentle, temperature and not dry, tonify without causing stagnation comprehensively, is especially applicable to having a delicate constitution and immunocompromised person takes.
Powder and micron refers to the powder of yardstick in micron level, has the dispersivity of height and large specific surface, thereby makes itThere is unique physics and chemistry characteristic. Raw-food material is ground into and both keeps original natural feeding habits, there is again micron order chiThe raw-food material powder of degree, has ensured that micron order raw-food material powder and former raw-food material key property are consistent substantially, itsHow broken cell membrane is, and its nutritional labeling is more easily absorbed by the body, and its trophic function can be brought into play better. ForBe convenient to packaging, carry and take, can adopt dry method or wet method by micron order raw-food material powder make 0.2-3.0mmGrain.
Summary of the invention
A preparation method for Korean red ginseng fruit of Chinese wolfberry breaking-wall cell Ultramicro-powder, its feature is as follows:
(1) raw material weight is that Korea S produces the raw fresh garden ginsent 100-400g in Koryo of 4-5, fruit of Chinese wolfberry 450-490g, Chinese yam 450-490g;
(2) by the fresh garden ginsent in Korea S Koryo in (1), place in intelligent steaming ginseng cabinet, control 60-95 DEG C of needs 0.5-of heat temperature raising1h; Control 95-98 DEG C and continue to steam 2-2.5h; Control cooling 98-66 DEG C, after 1-1.5h, take out, room temperature is placed 3.5-4h, becomesKorean red ginseng semi-finished product;
(3) the Korean red ginseng semi-finished product in (2) are put into intelligent drying chamber, automatically control 60-70 DEG C by 5 temp probesDry 8-10h, and automatically control every 0.5-1h air blast humidity discharging 1 time, lower palpus taken out;
(4) the Korean red ginseng semi-finished product after lower palpus in (3) are put into distilled panax water concentrate and flood 5-6h;
(5) by (4) through the impregnated Korean red ginseng semi-finished product of distilled panax water concentrate, in glass room, place 42-45h night;Daytime is airing 27-30h in glass room;
(6) the Korean red ginseng semi-finished product of airing in (5) are put into intelligent drying chamber, automatically control by 5 temp probes51-55 DEG C is dry, and automatically controls every 0.5-2h air blast humidity discharging 1 time, reach below 12% to Korean red ginseng semi-finished product moisture,Become Korean red ginseng;
(7) get moisture in (6) and reach the Korean red ginseng below 12%, at 100,000 grades of clean areas, be crushed into Ordinary pulverization machine10-60 order powder;
(8) by Korean red ginseng 10-60 order powder in (7), at 100,000 grades of clean areas, with airflow milling or the subzero 10-of vibromill control20 DEG C are crushed into 10-200 powder and micron, are Korean red ginseng breaking-wall cell Ultramicro-powder;
(9) or by Korean red ginseng 10-60 order powder in (7), at 100,000 grades of clean areas, subzero by airflow milling or vibromill control10-20 DEG C is crushed into 10-200 powder and micron, and every gram of red ginseng powder and micron add water 0.5-0.8g, glucose 0.5-0.8g, addLysozyme β-1.3-dextranase 10-20mg or protease 10-20mg, mix, and controls temperature 40-45 DEG C, and pH5-5.5 keeps72-96h, is Korean red ginseng breaking-wall cell Ultramicro-powder;
(10), by fruit of Chinese wolfberry 450-490g, Chinese yam 450-490g in (1), be 10-200 micron according to method co-grinding in (8)Powder, is the fruit of Chinese wolfberry, Chinese yam breaking-wall cell Ultramicro-powder;
(11) middle to Korean red ginseng breaking-wall cell Ultramicro-powder in (8) or (9) and (10) fruit of Chinese wolfberry, Chinese yam breaking-wall cell Ultramicro-powder are mixedEven, at 100,000 grades of clean areas, put into vaporium and suck steam, mix, compressing tablet, pulverizes this compressing tablet for 0.2-3.0mm particle,Be Korean red ginseng fruit of Chinese wolfberry breaking-wall cell Ultramicro-powder; Or by Korean red ginseng breaking-wall cell Ultramicro-powder in (8) or (9) and (10)The fruit of Chinese wolfberry, Chinese yam breaking-wall cell Ultramicro-powder mix, and compressing tablet pulverizes this compressing tablet for 0.2-3.0mm particle, is Korean red ginseng Chinese hollyMatrimony vine breaking-wall cell Ultramicro-powder; Or add 5-45% water or the ethanol softwood processed of breaking-wall cell Ultramicro-powder weight, and granulate, dry, wholeGrain is 0.2-3.0mm particle, is Korean red ginseng fruit of Chinese wolfberry breaking-wall cell Ultramicro-powder, packaging.
Percentage composition of the present invention is weight percentage.
Detailed description of the invention
The preparation method who relates to a kind of Korean red ginseng fruit of Chinese wolfberry breaking-wall cell Ultramicro-powder of the present invention comprises following examples,The following examples can further illustrate the present invention, but do not limit the present invention in any way.
Embodiment 1:
1. a preparation method for Korean red ginseng fruit of Chinese wolfberry breaking-wall cell Ultramicro-powder, its feature is as follows:
(1) raw material weight is that Korea S produces 4 years raw fresh garden ginsent 100g in Koryo, fruit of Chinese wolfberry 490g, Chinese yam 490g;
(2) by the fresh garden ginsent in Korea S Koryo in (1), place in intelligent steaming ginseng cabinet, control 60-95 DEG C of needs 0.5h of heat temperature raising;Control 95 DEG C and continue to steam 2.5h; Control cooling 98-66 DEG C, after 1h, take out, room temperature is placed 3.5h, becomes Korean red ginseng semi-finished product;
(3) the Korean red ginseng semi-finished product in (2) are put into intelligent drying chamber, automatically control 60 DEG C by 5 temp probes and doDry 10h, and automatically control every 0.5h air blast humidity discharging 1 time, lower palpus taken out;
(4) the Korean red ginseng semi-finished product after lower palpus in (3) are put into distilled panax water concentrate and flood 5h;
(5) by (4) through the impregnated Korean red ginseng semi-finished product of distilled panax water concentrate, in night glass room, place 42h; Exist daytimeAiring 30h in glass room;
(6) the Korean red ginseng semi-finished product of airing in (5) are put into intelligent drying chamber, automatically control by 5 temp probes51 DEG C dry, and automatically control every 0.5h air blast humidity discharging 1 time, reaches below 12% to Korean red ginseng semi-finished product moisture, becomesKorean red ginseng;
(7) get moisture in (6) and reach the Korean red ginseng below 12%, at 100,000 grades of clean areas, be crushed into Ordinary pulverization machine10 order powder;
(8) by Korean red ginseng 10 order powder in (7), at 100,000 grades of clean areas, with airflow milling or the subzero 10 DEG C of generals of vibromill controlIts pulverizing is 200 powder and micron, is Korean red ginseng breaking-wall cell Ultramicro-powder;
(9) or by Korean red ginseng 10 order powder in (7), at 100,000 grades of clean areas, with subzero 10 DEG C of airflow milling or vibromill controlBe crushed into 10 powder and micron, every gram of red ginseng powder and micron add water 0.5g, glucose 0.5g, add lysozyme β-1.3-dextranase10mg or protease 10mg, mix, and controls 40 DEG C of temperature, and pH5 keeps 96h, is Korean red ginseng breaking-wall cell Ultramicro-powder;
(10) by fruit of Chinese wolfberry 490g, Chinese yam 490g in (1), be 10 powder and micron according to method co-grinding in (8), be matrimony vineSon, Chinese yam breaking-wall cell Ultramicro-powder;
(11) middle to Korean red ginseng breaking-wall cell Ultramicro-powder in (8) or (9) and (10) fruit of Chinese wolfberry, Chinese yam breaking-wall cell Ultramicro-powder are mixedEven, at 100,000 grades of clean areas, put into vaporium and suck steam, mix, compressing tablet, pulverizes this compressing tablet for 0.2mm particle, isKorean red ginseng fruit of Chinese wolfberry breaking-wall cell Ultramicro-powder; Or by middle to Korean red ginseng breaking-wall cell Ultramicro-powder in (8) or (9) and (10) matrimony vineSon, Chinese yam breaking-wall cell Ultramicro-powder mix, and compressing tablet pulverizes this compressing tablet for 0.2mm particle, is Korean red ginseng fruit of Chinese wolfberry cellBroken wall Ultramicro-powder; Or add 5 water or the ethanol softwood processed of breaking-wall cell Ultramicro-powder weight, and granulate, to dry, whole grain is 0.2-3.0mm particle, is Korean red ginseng fruit of Chinese wolfberry breaking-wall cell Ultramicro-powder, packaging.
Embodiment 2:
1. a preparation method for Korean red ginseng fruit of Chinese wolfberry breaking-wall cell Ultramicro-powder, its feature is as follows:
(1) raw material weight is that Korea S produces 5 years raw fresh garden ginsent 400g in Koryo, fruit of Chinese wolfberry 450g, Chinese yam 450g;
(2) by the fresh garden ginsent in Korea S Koryo in (1), place in intelligent steaming ginseng cabinet, control 60-95 DEG C of needs 1h of heat temperature raising; ControlMake 98 DEG C and continue to steam 2h; Control cooling 98-66 DEG C, after 1.5h, take out, room temperature is placed 4h, becomes Korean red ginseng semi-finished product;
(3) the Korean red ginseng semi-finished product in (2) are put into intelligent drying chamber, automatically control 70 DEG C by 5 temp probes and doDry 8h, and automatically control every 1h air blast humidity discharging 1 time, lower palpus taken out;
(4) the Korean red ginseng semi-finished product after lower palpus in (3) are put into distilled panax water concentrate and flood 6h;
(5) by (4) through the impregnated Korean red ginseng semi-finished product of distilled panax water concentrate, in night glass room, place 45h; Exist daytimeAiring 27h in glass room;
(6) the Korean red ginseng semi-finished product of airing in (5) are put into intelligent drying chamber, automatically control by 5 temp probes55 DEG C dry, and automatically control every 2h air blast humidity discharging 1 time, reaches below 12% to Korean red ginseng semi-finished product moisture, becomes heightBeautiful red ginseng;
(7) get moisture in (6) and reach the Korean red ginseng below 12%, at 100,000 grades of clean areas, be crushed into Ordinary pulverization machine60 order powder;
(8) by Korean red ginseng 60 order powder in (7), at 100,000 grades of clean areas, with airflow milling or the subzero 20 DEG C of generals of vibromill controlIts pulverizing is 200 powder and micron, is Korean red ginseng breaking-wall cell Ultramicro-powder;
(9) or by Korean red ginseng 60 order powder in (7), at 100,000 grades of clean areas, with subzero 20 DEG C of airflow milling or vibromill controlBe crushed into 200 powder and micron, every gram of red ginseng powder and micron add water 0.8g, glucose 0.8g, add lysozyme β-1.3-glucanEnzyme 20mg or protease 20mg, mix, and controls temperature 45 C, and pH5.5 keeps 72h, is Korean red ginseng breaking-wall cell ultra microPowder;
(10) by fruit of Chinese wolfberry 450g, Chinese yam 450g in (1), be 200 powder and micron according to method co-grinding in (8), be matrimony vineSon, Chinese yam breaking-wall cell Ultramicro-powder;
(11) middle to Korean red ginseng breaking-wall cell Ultramicro-powder in (8) or (9) and (10) fruit of Chinese wolfberry, Chinese yam breaking-wall cell Ultramicro-powder are mixedEven, at 100,000 grades of clean areas, put into vaporium and suck steam, mix, compressing tablet, pulverizes this compressing tablet for 3.0mm particle, isKorean red ginseng fruit of Chinese wolfberry breaking-wall cell Ultramicro-powder; Or by middle to Korean red ginseng breaking-wall cell Ultramicro-powder in (8) or (9) and (10) matrimony vineSon, Chinese yam breaking-wall cell Ultramicro-powder mix, and compressing tablet pulverizes this compressing tablet for 3.0mm particle, is Korean red ginseng fruit of Chinese wolfberry cellBroken wall Ultramicro-powder; Or add 45% water or the ethanol softwood processed of breaking-wall cell Ultramicro-powder weight, and granulate, to dry, whole grain is 3.0mmParticle, is Korean red ginseng fruit of Chinese wolfberry breaking-wall cell Ultramicro-powder, packaging.
Claims (1)
1. a preparation method for Korean red ginseng fruit of Chinese wolfberry breaking-wall cell Ultramicro-powder, its feature is as follows:
(1) raw material weight is that Korea S produces the raw fresh garden ginsent 100-400g in Koryo of 4-5, fruit of Chinese wolfberry 450-490g, Chinese yam 450-490g;
(2) by the fresh garden ginsent in Korea S Koryo in (1), place in intelligent steaming ginseng cabinet, control 60-95 DEG C of needs 0.5-of heat temperature raising1h; Control 95-98 DEG C and continue to steam 2-2.5h; Control cooling 98-66 DEG C, after 1-1.5h, take out, room temperature is placed 3.5-4h, becomesKorean red ginseng semi-finished product;
(3) the Korean red ginseng semi-finished product in (2) are put into intelligent drying chamber, automatically control 60-70 DEG C by 5 temp probesDry 8-10h, and automatically control every 0.5-1h air blast humidity discharging 1 time, lower palpus taken out;
(4) the Korean red ginseng semi-finished product after lower palpus in (3) are put into distilled panax water concentrate and flood 5-6h;
(5) by (4) through the impregnated Korean red ginseng semi-finished product of distilled panax water concentrate, in glass room, place 42-45h night;Daytime is airing 27-30h in glass room;
(6) the Korean red ginseng semi-finished product of airing in (5) are put into intelligent drying chamber, automatically control by 5 temp probes51-55 DEG C is dry, and automatically controls every 0.5-2h air blast humidity discharging 1 time, reach below 12% to Korean red ginseng semi-finished product moisture,Become Korean red ginseng;
(7) get moisture in (6) and reach the Korean red ginseng below 12%, at 100,000 grades of clean areas, be crushed into Ordinary pulverization machine10-60 order powder;
(8) by Korean red ginseng 10-60 order powder in (7), at 100,000 grades of clean areas, with airflow milling or the subzero 10-of vibromill control20 DEG C are crushed into 10-200 powder and micron, are Korean red ginseng breaking-wall cell Ultramicro-powder;
(9) or by Korean red ginseng 10-60 order powder in (7), at 100,000 grades of clean areas, subzero by airflow milling or vibromill control10-20 DEG C is crushed into 10-200 powder and micron, and every gram of red ginseng powder and micron add water 0.5-0.8g, glucose 0.5-0.8g, addLysozyme β-1.3-dextranase 10-20mg or protease 10-20mg, mix, and controls temperature 40-45 DEG C, and pH5-5.5 keeps72-96h, is Korean red ginseng breaking-wall cell Ultramicro-powder;
(10), by fruit of Chinese wolfberry 450-490g, Chinese yam 450-490g in (1), be 10-200 micron according to method co-grinding in (8)Powder, is the fruit of Chinese wolfberry, Chinese yam breaking-wall cell Ultramicro-powder;
(11) middle to Korean red ginseng breaking-wall cell Ultramicro-powder in (8) or (9) and (10) fruit of Chinese wolfberry, Chinese yam breaking-wall cell Ultramicro-powder are mixedEven, at 100,000 grades of clean areas, put into vaporium and suck steam, mix, compressing tablet, pulverizes this compressing tablet for 0.2-3.0mm particle,Be Korean red ginseng fruit of Chinese wolfberry breaking-wall cell Ultramicro-powder; Or by Korean red ginseng breaking-wall cell Ultramicro-powder in (8) or (9) and (10)The fruit of Chinese wolfberry, Chinese yam breaking-wall cell Ultramicro-powder mix, and compressing tablet pulverizes this compressing tablet for 0.2-3.0mm particle, is Korean red ginseng Chinese hollyMatrimony vine breaking-wall cell Ultramicro-powder; Or add 5-45% water or the ethanol softwood processed of breaking-wall cell Ultramicro-powder weight, and granulate, dry, wholeGrain is 0.2-3.0mm particle, is Korean red ginseng fruit of Chinese wolfberry breaking-wall cell Ultramicro-powder, packaging.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201610000596.4A CN105595336A (en) | 2016-01-04 | 2016-01-04 | Preparation method of radix ginseng rubra and fructus lycii cell-wall breaking ultra-fine powder |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201610000596.4A CN105595336A (en) | 2016-01-04 | 2016-01-04 | Preparation method of radix ginseng rubra and fructus lycii cell-wall breaking ultra-fine powder |
Publications (1)
Publication Number | Publication Date |
---|---|
CN105595336A true CN105595336A (en) | 2016-05-25 |
Family
ID=55976138
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201610000596.4A Pending CN105595336A (en) | 2016-01-04 | 2016-01-04 | Preparation method of radix ginseng rubra and fructus lycii cell-wall breaking ultra-fine powder |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN105595336A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105942068A (en) * | 2016-05-28 | 2016-09-21 | 环翠楼红参生物科技股份有限公司 | Preparation method of Korean red ginseng soup |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104783162A (en) * | 2015-04-27 | 2015-07-22 | 威海环翠楼红参科技有限公司 | Preparation method of novel resource food Korean red ginseng wall-broken micron particles |
CN104783163A (en) * | 2015-04-27 | 2015-07-22 | 威海环翠楼红参科技有限公司 | Preparation method of novel resource food Korean red ginseng wall-broken micron particles |
CN104824657A (en) * | 2015-06-05 | 2015-08-12 | 威海环翠楼红参科技有限公司 | Method for preparing new resource food-Korean red ginseng wall-breaking powder |
CN104856037A (en) * | 2015-06-05 | 2015-08-26 | 威海环翠楼红参科技有限公司 | Preparing method of novel-resource food that is Korean red ginseng wall-broken powder preparation |
-
2016
- 2016-01-04 CN CN201610000596.4A patent/CN105595336A/en active Pending
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104783162A (en) * | 2015-04-27 | 2015-07-22 | 威海环翠楼红参科技有限公司 | Preparation method of novel resource food Korean red ginseng wall-broken micron particles |
CN104783163A (en) * | 2015-04-27 | 2015-07-22 | 威海环翠楼红参科技有限公司 | Preparation method of novel resource food Korean red ginseng wall-broken micron particles |
CN104824657A (en) * | 2015-06-05 | 2015-08-12 | 威海环翠楼红参科技有限公司 | Method for preparing new resource food-Korean red ginseng wall-breaking powder |
CN104856037A (en) * | 2015-06-05 | 2015-08-26 | 威海环翠楼红参科技有限公司 | Preparing method of novel-resource food that is Korean red ginseng wall-broken powder preparation |
Non-Patent Citations (1)
Title |
---|
王晓利: "《生物化学技术》", 30 September 2014, 中国轻工业出版社 * |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105942068A (en) * | 2016-05-28 | 2016-09-21 | 环翠楼红参生物科技股份有限公司 | Preparation method of Korean red ginseng soup |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN107296949A (en) | Integration of drinking and medicinal herbs compound formulation and its preparation method and application | |
CN103416625B (en) | Barley piglet feed and preparation method thereof | |
CN102524408A (en) | Nutritious soybean milk and preparation method thereof | |
CN102823653A (en) | Series compound health-care medicated food milk tablets and preparation method thereof | |
CN101773595B (en) | Herbal tea for clearing liver and improving eyesight | |
CN109966417A (en) | A kind of solid beverage for diabetic population | |
CN103859378A (en) | Formula and preparation method of life cultivation and health preservation food helpful for reducing blood sugar | |
CN103609992B (en) | Preparation method of Korean red ginseng cream | |
CN103027155A (en) | Mulberry leaf lipid-reducing pressure-reducing health-care tea and preparation method thereof | |
CN105495602A (en) | Preparation method for radix ginseng rubra cell-wall breaking superfine powder particles | |
CN105454576A (en) | Jasmine-flower-comprising assorted Chinese herbal tea and preparation method thereof | |
CN108991078A (en) | A kind of mulberry leaf food of prevention and control rich people's disease and preparation method thereof | |
CN102940219B (en) | Potato cake and making method thereof | |
CN106962922A (en) | A kind of health composition for nourishing beauty treatment, beverage and preparation method thereof | |
CN108813501A (en) | With the relieving cough and reducing sputum health honey paste relievingd asthma and adjust function of human body of clearing heat and moistening lung | |
CN104798950A (en) | Immune kungfu tea and preparation method thereof | |
CN107412345A (en) | A kind of passion fruit seed oil lozenge and preparation method thereof | |
CN105495603A (en) | Preparation method for radix ginseng rubra-fructus crataegi cell-wall breaking superfine powder | |
CN103798434A (en) | Health care tea bag as well as preparation method thereof | |
CN103749827A (en) | Preparation method of red ginseng/fig tea | |
CN105559078A (en) | Composition having blood replenishing efficacy and preparation method thereof | |
CN101889685B (en) | Natural plant health care product and preparation method thereof | |
KR102480311B1 (en) | The manufacturing method of making healthcare food composition for costitutional group | |
CN105595336A (en) | Preparation method of radix ginseng rubra and fructus lycii cell-wall breaking ultra-fine powder | |
CN103461565A (en) | Winter health preserving early tea teabag |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
RJ01 | Rejection of invention patent application after publication | ||
RJ01 | Rejection of invention patent application after publication |
Application publication date: 20160525 |