CN112717076A - Ointment for treating onychomycosis and preparation method thereof - Google Patents
Ointment for treating onychomycosis and preparation method thereof Download PDFInfo
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8962—Allium, e.g. garden onion, leek, garlic or chives
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
- A61K35/64—Insects, e.g. bees, wasps or fleas
- A61K35/644—Beeswax; Propolis; Royal jelly; Honey
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/482—Cassia, e.g. golden shower tree
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/488—Pueraria (kudzu)
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/61—Myrtaceae (Myrtle family), e.g. teatree or eucalyptus
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
- A61K36/714—Aconitum (monkshood)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/19—Preparation or pretreatment of starting material involving fermentation using yeast, bacteria or both; enzymatic treatment
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
Abstract
The invention provides an ointment for treating onychomycosis and a preparation method thereof, and belongs to the technical field of traditional Chinese medicines. The invention provides an ointment for treating onychomycosis, which is prepared by mixing traditional Chinese medicine components and pharmaceutic adjuvants; the medicinal auxiliary materials comprise vaseline and bean dregs; the traditional Chinese medicine components are prepared from the following materials: garlic, black beans, clove, liquorice, loquat leaves, monkshood, kudzu root, cassia seeds, honey and rice bran. The invention takes garlic, clove, liquorice, loquat leaves, monkshood, kudzu root, cassia seed and the like as main raw materials, Chinese medicinal components are prepared by vinegar soaking, fermentation or extraction and other modes, and the ointment for treating onychomycosis is prepared after auxiliary materials are added. The invention takes natural Chinese herbal medicines as the basis, has low cost, no toxic or side effect, can realize the rapid treatment of the onychomycosis, and can be widely applied to various patients.
Description
Technical Field
The invention relates to the technical field of traditional Chinese medicines, in particular to an ointment for treating onychomycosis and a preparation method thereof.
Background
Onychomycosis, commonly known as onychomycosis, refers to a disease caused by dermatophytes invading the nail plate or under the nail. Onychomycosis is an infection of the nail caused by fungi such as dermatophytes, yeasts and non-dermatophytes. Onychomycosis is common: the fungal onychomycosis (superficial onychomycosis) is limited to one or the top of the onychomycosis; secondly, the onychomycosis is classified into distal lateral type, proximal onychomycosis type and superficial white type, and the lesions start from both sides or distal end of the nail and then infect under the nail plate. Onychomycosis is usually caused by various fungi such as trichophyton rubrum, trichophyton mentagrophytes, and epidermophyton floccosum. A few of them are caused by other filamentous fungi, yeast-like bacteria and yeasts, and occasionally by sporozoites, fusarium and aspergillus terreus, and most of them are found in dystrophic nails.
The prior treatment technologies mainly comprise three types of operation removal, oral administration of medicines and external treatment. Surgical removal is not suitable for patients with heart disease, hypertension, diabetes and the like, and mainly involves large wound surface, bleeding and easy recurrence. The requirement of oral medicines on medicines is high, the medicines can play an antibacterial role only by reaching the deck where fungi are parasitized, the dosage is large, the time is long, and adverse reactions of the medicines can exist. The external therapy is relatively safe and wide in application range, and according to different medicaments, the methods of local medicine application, package cutting treatment and the like are included, the improvement of the self resistance of a patient is also a great factor in the process, and the ringworm of the nails can be cured only by the repeated effect of shoulder burden prevention and treatment.
The garlic soaked by vinegar is a folk prescription which has medical effects of softening the calcium of the onychomycosis and inhibiting and killing fungi causing the onychomycosis, but the garlic is spicy, cannot be tolerated by users, and easily causes relapse if not cleaned in time.
Therefore, there is a need for an ointment for treating onychomycosis and a preparation method thereof.
Disclosure of Invention
In order to solve the technical problems, the invention provides an ointment for treating onychomycosis and a preparation method thereof. The invention takes natural Chinese herbal medicines as the basis, has low cost, no toxic or side effect, can realize the rapid treatment of the onychomycosis, and can be widely applied to various patients.
In order to achieve the purpose, the invention provides the following technical scheme:
on the one hand, the invention provides an ointment for treating onychomycosis, which is prepared by mixing traditional Chinese medicine components and pharmaceutic adjuvants.
Further, the pharmaceutic adjuvant comprises vaseline and bean dregs. Further, the medicinal auxiliary materials comprise 100-350 parts of vaseline and 10-40 parts of bean dregs in parts by weight.
Further, the traditional Chinese medicine component comprises the following materials: garlic, black beans, clove, liquorice, loquat leaves, monkshood, kudzu root, cassia seeds, honey and rice bran.
Further, the traditional Chinese medicine components comprise the following materials in parts by weight: 20-50 parts of garlic, 1-10 parts of black beans, 1-10 parts of clove, 1-10 parts of liquorice, 1-5 parts of loquat leaves, 1-5 parts of monkshood, 1-5 parts of kudzu roots, 1-10 parts of cassia seeds, 10-50 parts of rice bran and 10-20 parts of honey.
Further, the preparation process of the fermentation liquor of the traditional Chinese medicine is as follows:
1) peeling fresh Bulbus Allii, mashing, adding old vinegar, and soaking to obtain vinegar-processed Bulbus Allii solution;
2) inoculating black bean, radix Puerariae, testa oryzae and Mel with zymocyte, mixing, and fermenting to obtain pre-fermented solution;
3) extracting flos Caryophylli, Glycyrrhrizae radix, folium Eriobotryae, radix Aconiti and semen Cassiae with ethanol water solution, and concentrating to obtain crude extract;
4) mixing the pre-fermented solution, vinegar-processed garlic solution and the crude extract sufficiently to obtain the traditional Chinese medicine component.
Further, the preparation process of the vinegar garlic liquid is as follows: peeling fresh Bulbus Allii, mashing, adding old vinegar, soaking, fermenting at 0-10 deg.C for 1 month, stirring, adding old vinegar, and fermenting for 1 month.
Further, the preparation process of the pre-fermentation liquid is as follows: pulverizing semen Sojae Atricolor, radix Puerariae and testa oryzae, steam sterilizing under 0.1MPa for 20-30min, adding Mel, inoculating zymocyte, mixing, keeping fermentation temperature at 23-37 deg.C, continuously fermenting for 2 months, stirring and adding zymocyte every 7 days until fermentation is complete, filtering to obtain filtrate, and sterilizing at 75-90 deg.C for 4-10min to obtain pre-fermentation solution. Inoculation of the fermentation tubes can be accomplished using techniques conventional in the art.
Further, the zymocyte is selected from: one or more of lactobacillus, yeast, Bacillus bifidus, Aspergillus niger, Acetobacter, Aspergillus oryzae, Lactobacillus lactis, and Lactobacillus rhamnosus.
Further, the preparation process of the crude extract is as follows: decocting flos Caryophylli, Glycyrrhrizae radix, folium Eriobotryae, radix Aconiti and semen Cassiae with 2 times volume of ethanol water solution for 2-3 times, each time for 15-20 min, mixing extractive solutions, and vacuum concentrating. The ethanol content in the ethanol water solution is 50-80%.
Further, the traditional Chinese medicine components and the pharmaceutic adjuvant are fully mixed to prepare the ointment for treating the onychomycosis.
When the ointment is used, the ointment is smeared on the surface of the skin of the onychomycosis to form a drug storage film, so that the drug continuously penetrates through the horny layer and enters the active tissue of the skin to exert the drug effect, the volatilization of the drug can be reduced, and the drug can be exerted for a long time. By applying the ointment of the invention, the speed of entering skin active tissues through the horny layer is higher, so that the medicine can quickly exert the effect, the influence of oral medicines on intestines and stomach and other side effects is solved, and the defects of the existing external preparation can be overcome. The ointment can be uniformly administered only by applying the ointment on the affected part.
Compared with the prior art, the technical scheme provided by the invention has the following beneficial effects:
1) according to the invention, garlic is fermented to prepare the enzyme, and the enzyme is matched with various nutritional components in the traditional Chinese medicine, wherein the components are all from natural medicines, so that the safety is high, the garlic enzyme has an obvious antifungal effect, and can supplement nutrition of the diseased skin in time, and improve the resistance of the organism under the condition of ensuring complete removal of fungi.
2) The ferment prepared by fermenting the black beans, the kudzuvine roots, the rice bran and the honey can effectively cover up the smell of the garlic ferment, improve the proportion of the nutrient components in the paste and be beneficial to improving the resistance of the sick skin organism. The honey and rice bran provide nutrition for the zymophyte and improve the activity of the zymophyte.
3) The clove, the liquorice, the loquat leaves, the radix aconiti and the cassia seed are extracted from the nutrient components by ethanol, so that the nutrient components in the traditional Chinese medicine components can be retained to the maximum extent, and the potential medicinal values of oxidation resistance, antibiosis and the like in the paste can be improved.
4) The traditional Chinese medicine auxiliary materials can enable the prepared paste to have proper viscosity, and meanwhile, the bean dregs can support the paste and can supplement nutrients of organisms, and the paste is not easy to flow after being coated and dried, so that the medicine can be ensured to quickly and durably exert the medicine effect on the affected part.
5) The invention has simple preparation process, low manufacturing cost, quick effect, high cure rate, no relapse, no toxic or side effect and simple and convenient use, and is suitable for all people of all ages and both sexes.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention more apparent, the present invention is further described in detail with reference to the following embodiments. It should be understood that the description is intended to be exemplary only, and is not intended to limit the scope of the present invention. Moreover, in the following description, descriptions of well-known structures and techniques are omitted so as to not unnecessarily obscure the concepts of the present invention.
Example 1
The embodiment provides an ointment for treating onychomycosis, which is prepared by mixing traditional Chinese medicine components and pharmaceutic adjuvants:
the medicinal auxiliary materials comprise 100 parts of vaseline and 10 parts of bean dregs in parts by weight;
the traditional Chinese medicine component is prepared from the following materials in parts by weight: 20 parts of garlic, 1 part of black beans, 1 part of clove, 1 part of liquorice, 1 part of loquat leaves, 1 part of monkshood, 1 part of kudzu root, 1 part of cassia seeds, 10 parts of rice bran and 10 parts of honey.
The preparation process of the traditional Chinese medicine components is as follows:
1) peeling fresh Bulbus Allii, mashing, adding old vinegar, soaking, fermenting at 0-10 deg.C for 1 month, stirring, adding old vinegar, fermenting for 1 month, and soaking to obtain vinegar-Bulbus Allii solution;
2) pulverizing semen Sojae Atricolor, radix Puerariae and testa oryzae, steam sterilizing under 0.1MPa for 20-30min, adding Mel, inoculating zymocyte, mixing, keeping fermentation temperature at 23-37 deg.C, continuously fermenting for 2 months, stirring and adding zymocyte every 7 days until fermentation is complete, filtering to obtain filtrate, sterilizing at 75-90 deg.C for 4-10min to obtain pre-fermentation solution;
3) decocting flos Caryophylli, Glycyrrhrizae radix, folium Eriobotryae, radix Aconiti and semen Cassiae with 2 times volume of ethanol water solution for 2-3 times, each time for 15-20 min, mixing extractive solutions, and vacuum concentrating to obtain crude extract;
4) mixing the pre-fermented solution, vinegar-processed garlic solution and the crude extract sufficiently to obtain the traditional Chinese medicine components;
5) the traditional Chinese medicine components and the pharmaceutic adjuvant are fully mixed to prepare the ointment for treating the onychomycosis.
Further, the zymocyte is selected from: the mass ratio of the mixed strains of the lactobacillus and the microzyme is 1: 1. The inoculation amount of the zymophyte is 1 percent of the weight of the fermentation component.
Example 2
The embodiment provides an ointment for treating onychomycosis, which is prepared by mixing traditional Chinese medicine components and pharmaceutic adjuvants:
according to the weight parts of the ointment, the pharmaceutic adjuvant comprises 350 parts of vaseline and 10-40 parts of bean dregs;
the traditional Chinese medicine component is prepared from the following materials in parts by weight: 50 parts of garlic, 10 parts of black beans, 10 parts of clove, 1 part of liquorice, 5 parts of loquat leaves, 5 parts of monkshood, 5 parts of kudzu root, 10 parts of cassia seeds, 50 parts of rice bran and 10 parts of honey.
The preparation process of the traditional Chinese medicine components is as follows:
1) peeling fresh Bulbus Allii, mashing, adding old vinegar, soaking, fermenting at 0-10 deg.C for 1 month, stirring, adding old vinegar, fermenting for 1 month, and soaking to obtain vinegar-Bulbus Allii solution;
2) pulverizing semen Sojae Atricolor, radix Puerariae and testa oryzae, steam sterilizing under 0.1MPa for 20-30min, adding Mel, inoculating zymocyte, mixing, keeping fermentation temperature at 23-37 deg.C, continuously fermenting for 2 months, stirring and adding zymocyte every 7 days until fermentation is complete, filtering to obtain filtrate, sterilizing at 75-90 deg.C for 4-10min to obtain pre-fermentation solution;
3) decocting flos Caryophylli, Glycyrrhrizae radix, folium Eriobotryae, radix Aconiti and semen Cassiae with 2 times volume of ethanol water solution for 2-3 times, each time for 15-20 min, mixing extractive solutions, and vacuum concentrating to obtain crude extract;
4) mixing the pre-fermented solution, vinegar-processed garlic solution and the crude extract sufficiently to obtain the traditional Chinese medicine components;
5) the traditional Chinese medicine components and the pharmaceutic adjuvant are fully mixed to prepare the ointment for treating the onychomycosis.
Further, the zymocyte is selected from: the inoculation amount of the yeast is 1 percent of the weight of the fermentation component.
Example 3
The embodiment provides an ointment for treating onychomycosis, which is prepared by mixing traditional Chinese medicine components and pharmaceutic adjuvants:
the medicinal auxiliary materials comprise 200 parts of vaseline and 30 parts of bean dregs in parts by weight;
the traditional Chinese medicine component is prepared from the following materials in parts by weight: 30 parts of garlic, 5 parts of black beans, 1 part of clove, 5 parts of liquorice, 2 parts of loquat leaves, 2 parts of monkshood, 5 parts of kudzu root, 3 parts of cassia seeds, 16 parts of rice bran and 20 parts of honey.
The preparation process of the traditional Chinese medicine components is as follows:
1) peeling fresh Bulbus Allii, mashing, adding old vinegar, soaking, fermenting at 0-10 deg.C for 1 month, stirring, adding old vinegar, fermenting for 1 month, and soaking to obtain vinegar-Bulbus Allii solution;
2) pulverizing semen Sojae Atricolor, radix Puerariae and testa oryzae, steam sterilizing under 0.1MPa for 20-30min, adding Mel, inoculating zymocyte, mixing, keeping fermentation temperature at 23-37 deg.C, continuously fermenting for 2 months, stirring and adding zymocyte every 7 days until fermentation is complete, filtering to obtain filtrate, sterilizing at 75-90 deg.C for 4-10min to obtain pre-fermentation solution;
3) decocting flos Caryophylli, Glycyrrhrizae radix, folium Eriobotryae, radix Aconiti and semen Cassiae with 2 times volume of ethanol water solution for 2-3 times, each time for 15-20 min, mixing extractive solutions, and vacuum concentrating to obtain crude extract;
4) mixing the pre-fermented solution, vinegar-processed garlic solution and the crude extract sufficiently to obtain the traditional Chinese medicine components;
5) the traditional Chinese medicine components and the pharmaceutic adjuvant are fully mixed to prepare the ointment for treating the onychomycosis.
Further, the zymocyte is selected from: the mass ratio of the mixed strains of the lactobacillus and the lactobacillus lactis is 1: 1. The inoculation amount of the zymophyte is 5 percent of the weight of the fermentation component.
Example 4
The embodiment provides an ointment for treating onychomycosis, which is prepared by mixing traditional Chinese medicine components and pharmaceutic adjuvants:
according to the weight part of the ointment, the pharmaceutic adjuvant comprises 350 parts of vaseline and 10 parts of bean dregs;
the traditional Chinese medicine component is prepared from the following materials in parts by weight: 50 parts of garlic, 1 part of black beans, 10 parts of clove, 10 parts of liquorice, 5 parts of loquat leaves, 1 part of monkshood, 5 parts of kudzu root, 1 part of cassia seeds, 50 parts of rice bran and 10 parts of honey.
The preparation process of the traditional Chinese medicine components is as follows:
1) peeling fresh Bulbus Allii, mashing, adding old vinegar, soaking, fermenting at 0-10 deg.C for 1 month, stirring, adding old vinegar, fermenting for 1 month, and soaking to obtain vinegar-Bulbus Allii solution;
2) pulverizing semen Sojae Atricolor, radix Puerariae and testa oryzae, steam sterilizing under 0.1MPa for 20-30min, adding Mel, inoculating zymocyte, mixing, keeping fermentation temperature at 23-37 deg.C, continuously fermenting for 2 months, stirring and adding zymocyte every 7 days until fermentation is complete, filtering to obtain filtrate, sterilizing at 75-90 deg.C for 4-10min to obtain pre-fermentation solution;
3) decocting flos Caryophylli, Glycyrrhrizae radix, folium Eriobotryae, radix Aconiti and semen Cassiae with 2 times volume of ethanol water solution for 2-3 times, each time for 15-20 min, mixing extractive solutions, and vacuum concentrating to obtain crude extract;
4) mixing the pre-fermented solution, vinegar-processed garlic solution and the crude extract sufficiently to obtain the traditional Chinese medicine components;
5) the traditional Chinese medicine components and the pharmaceutic adjuvant are fully mixed to prepare the ointment for treating the onychomycosis.
Further, the zymocyte is selected from: bifidobacterium, the inoculum size of the zymocyte is 10% of the weight of the zymocyte.
Example 5
The ointment prepared by the invention is applied to the affected part, the application thickness is about 5mm, after the surface is dried, the affected part is wrapped by gauze, every 1-2 days, the gauze is opened to remove the ointment on the surface and remove the softened onychomycosis, the softened onychomycosis can be quickly removed, and meanwhile, the medicine can be ensured to effectively permeate into the dermis of the affected part for sterilization and nutrition supplementation, the body resistance is improved, and the onychomycosis is removed. Can be removed in 14 days.
The embodiments of the present invention have been described in detail above, but they are merely exemplary, and the present invention is not equivalent to the above described embodiments. Any equivalent modifications and substitutions to those skilled in the art are also within the scope of the present invention. Accordingly, it is intended that all equivalent alterations and modifications be included within the scope of the invention, without departing from the spirit and scope of the invention.
Claims (10)
1. An ointment for treating onychomycosis is characterized by being prepared by mixing traditional Chinese medicine components and pharmaceutic adjuvants;
the traditional Chinese medicine components are prepared from the following materials: garlic, black beans, clove, liquorice, loquat leaves, monkshood, kudzu root, cassia seeds, honey and rice bran.
2. The ointment for treating onychomycosis according to claim 1, wherein the pharmaceutical excipients comprise vaseline and bean dregs.
3. The ointment for treating onychomycosis according to claim 1, wherein the pharmaceutic adjuvant comprises 100-350 parts by weight of vaseline and 10-40 parts by weight of bean dregs.
4. The ointment for treating onychomycosis according to claim 1, wherein the traditional Chinese medicine components comprise the following materials in parts by weight: 20-50 parts of garlic, 1-10 parts of black beans, 1-10 parts of clove, 1-10 parts of liquorice, 1-5 parts of loquat leaves, 1-5 parts of monkshood, 1-5 parts of kudzu roots, 1-10 parts of cassia seeds, 10-50 parts of rice bran and 10-20 parts of honey.
5. The ointment for treating onychomycosis according to claim 1, wherein the preparation process of the traditional Chinese medicine components is as follows:
1) peeling fresh Bulbus Allii, mashing, adding old vinegar, and soaking to obtain vinegar-processed Bulbus Allii solution;
2) inoculating black bean, radix Puerariae, testa oryzae and Mel with zymocyte, mixing, and fermenting to obtain pre-fermented solution;
3) extracting flos Caryophylli, Glycyrrhrizae radix, folium Eriobotryae, radix Aconiti and semen Cassiae with ethanol water solution, and concentrating to obtain crude extract;
4) mixing the pre-fermented solution, vinegar-processed garlic solution and the crude extract.
6. The ointment for treating onychomycosis according to claim 5, wherein the vinegar garlic solution is prepared by the following steps: peeling fresh Bulbus Allii, mashing, adding old vinegar, soaking, fermenting at 0-10 deg.C for 1 month, stirring, adding old vinegar, and fermenting for 1 month.
7. The ointment for treating onychomycosis according to claim 5, wherein the pre-fermentation solution is prepared by the following process: pulverizing semen Sojae Atricolor, radix Puerariae and testa oryzae, steam sterilizing under 0.1MPa for 20-30min, adding Mel, inoculating zymocyte, mixing, keeping fermentation temperature at 23-37 deg.C, continuously fermenting for 2 months, stirring and adding zymocyte every 7 days until fermentation is complete, filtering to obtain filtrate, and sterilizing at 75-90 deg.C for 4-10min to obtain pre-fermentation solution.
8. The ointment for treating onychomycosis according to claim 7, wherein the fermentation tubes are selected from the group consisting of: one or more of lactobacillus, yeast, Bacillus bifidus, Aspergillus niger, Acetobacter, Aspergillus oryzae, Lactobacillus lactis, and Lactobacillus rhamnosus.
9. The ointment for treating onychomycosis according to claim 5, wherein the crude extract is prepared by the following steps: decocting flos Caryophylli, Glycyrrhrizae radix, folium Eriobotryae, radix Aconiti and semen Cassiae with 2 times volume of ethanol water solution for 2-3 times, each time for 15-20 min, mixing extractive solutions, and vacuum concentrating.
10. The preparation method of the ointment for treating the onychomycosis is characterized by comprising the following specific steps of:
1) peeling fresh Bulbus Allii, mashing, adding old vinegar, and soaking to obtain vinegar-processed Bulbus Allii solution;
2) inoculating black bean, radix Puerariae, testa oryzae and Mel with zymocyte, mixing, and fermenting to obtain pre-fermented solution;
3) extracting flos Caryophylli, Glycyrrhrizae radix, folium Eriobotryae, radix Aconiti and semen Cassiae with ethanol water solution, and concentrating to obtain crude extract;
4) mixing the pre-fermented solution, vinegar-processed garlic solution and the crude extract sufficiently to obtain the traditional Chinese medicine components;
5) the traditional Chinese medicine components and the pharmaceutic adjuvant are fully mixed to prepare the ointment for treating the onychomycosis.
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| CN113995826A (en) * | 2021-11-22 | 2022-02-01 | 石彬 | External use infusion for treating onychomycosis by traditional Chinese medicine combination and preparation method thereof |
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