CN108235684B - Traditional Chinese medicine patch for softening scars - Google Patents
Traditional Chinese medicine patch for softening scars Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/618—Molluscs, e.g. fresh-water molluscs, oysters, clams, squids, octopus, cuttlefish, snails or slugs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/11—Pteridophyta or Filicophyta (ferns)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/483—Gleditsia (locust)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/49—Fagaceae (Beech family), e.g. oak or chestnut
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/60—Moraceae (Mulberry family), e.g. breadfruit or fig
- A61K36/605—Morus (mulberry)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/752—Citrus, e.g. lime, orange or lemon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
Abstract
A traditional Chinese medicine patch for softening scars comprises the following raw material components in parts by weight: 10-20 parts of orange peel; 10-15 parts of lycopodium clavatum; 10-15 parts of eggplant peel; 5-12 parts of mulberry twigs; 5-12 parts of chestnut leaves; 3-10 parts of polyethyl; 3-8 parts of abalone shell; 1.5-5 parts of fructus gleditsiae; 1.5-5 parts of calcined oyster; 1-3 parts of shrubalthea bark. The traditional Chinese medicine patch for softening scars provided by the invention can enable active ingredients of traditional Chinese medicines to smoothly penetrate through a skin barrier layer and be led into a skin deep layer, so that the effects of softening scars, dredging qi and blood, expelling turbid urine and correcting damaged parts of skin of the traditional Chinese medicine patch are fully exerted.
Description
Technical Field
The invention belongs to the field of traditional Chinese medicines, relates to a traditional Chinese medicine patch and a preparation method thereof, and particularly relates to a traditional Chinese medicine patch for softening scars.
Background
When the deep layer of human skin is wounded, the stress reaction and the inflammatory reaction of the wound surface lead to the growth factors of abnormal increase of matrix layers, induce the degeneration and transformation of matrix cells (fibroblasts and myofibroblasts) in the deep layer of the skin into scar cells, and generate scars. Moreover, although the scar cells do not have the division and proliferation capability and can die along with the metabolism of the scar cells, the scar tissues are maintained and abnormal proliferation can occur because the cell growth factors continuously induce the matrix cells to be transformed into the scar cells and supplement the scar cells which continuously die in the metabolism.
The repair process of scars is based on the normal exertion of various relevant cellular biological functions and depends on the interaction between cells, extracellular matrix and soluble mediators including growth factors and cytokines. In the existing scar repair treatment medicines, although the treatment technology of western medicines is updated all the time, the treatment effect is not good all the time in the long-term treatment process due to the single action mechanism. Because the cause of scar diseases is complex, the mechanism characteristics are variable, the advantages of the traditional Chinese medicine are obvious, and especially, the traditional Chinese medicine has made a remarkable breakthrough in the aspect of a transdermal drug delivery system. The transdermal drug delivery system has no first pass effect of liver, is not damaged by digestive enzymes of gastrointestinal tract, and has the advantages of maintaining long action time, reducing toxic and side effects and adverse reactions of the drug, and maintaining stable and lasting blood concentration, thereby improving the curative effect. However, most drugs have low speed and efficiency of penetrating the skin, so that the therapeutic effect of the transdermal absorption drugs in the clinical dermatology is not ideal. At present, the reasonable compatibility of Chinese herbs and how to enhance the transdermal absorption of the herbs are the focus of research.
Disclosure of Invention
In view of the above disadvantages, the present invention aims to provide a Chinese medicine patch for softening scars, which can enable effective ingredients of Chinese medicines to smoothly penetrate through a skin barrier layer and be guided into a skin deep layer, so as to fully exert the functions of softening scars, dredging qi and blood, expelling turbid urine and correcting damaged parts of skin.
The technical scheme of the invention is summarized as follows:
a traditional Chinese medicine patch for softening scars comprises the following raw material medicines:
the traditional Chinese medicine patch also comprises 2-6 parts by weight of transdermal enhancer for promoting the effective components of the traditional Chinese medicine to penetrate the skin and repair scars. The transdermal enhancer comprises 40-60 wt% of wintergreen oil, 30-50 wt% of eucalyptus oil, 3-7 wt% of glycerin and 2-5 wt% of tetradecanol, and the four substances are used in a matching manner, so that the transdermal enhancer can effectively permeate into scar keratin tissue by exerting a synergistic effect, and the effective components of the traditional Chinese medicine patch are promoted to exert.
In the formula of the traditional Chinese medicine patch for softening the scars, the orange peel, the lycopodium clavatum and the eggplant peel are monarch drugs, and have the functions of chiseling the swelling, softening the scars and dredging local venation and vein vessels of the wound surface; ramulus mori, chestnut leaves, lavender and concha haliotidis are used as ministerial drugs, so that the effects of removing blood stasis, promoting tissue regeneration and promoting skin repair are achieved; fructus Gleditsiae Abnormalis and Concha Ostreae preparata as adjuvant drugs, and has effects of eliminating muscle and removing food stagnation, and discharging turbid; the shrubalthea bark has the functions of cooling blood and relieving itching, and can effectively relieve itching symptoms in the process of softening scars and repairing injured skin.
Preferably, the raw material components are ground into powder, and then are soaked in ethanol, extracted and filtered to prepare the scar softening patch.
Preferably, the particle size of the powder is 100-500 μm, the extraction is dynamic extraction, in the application document, the particle size of the raw material powder does not need to be too fine, the extraction of the effective components can be realized with the particle size of 100-500 μm, the crushing cost is reduced, and the too high dynamic extraction pressure caused by the too fine powder is avoided.
Preferably, the powder is dynamically extracted by 90 wt% ethanol, so that the dissolution speed of the active ingredients is high and the dissolution efficiency is high.
Preferably, in the dynamic extraction process, the 90 wt% ethanol is 5-8 times of the powder volume, so as to ensure sufficient extraction of the effective components of the traditional Chinese medicine.
The invention has the beneficial effects that: the traditional Chinese medicine patch for softening scars provided by the invention can soften and degrade scar tissues, further repair and regenerate the injured skin at the scar positions, fade and repair scars, particularly old scars, and has an obvious effect, wherein the old scars are close to normal skin color.
Detailed Description
The present invention is further described in detail below with reference to examples so that those skilled in the art can practice the invention with reference to the description.
Example 1
A traditional Chinese medicine patch for softening scars comprises the following raw material components in parts by weight: 10 parts of orange peel; 10 parts of common clubmoss herb; 10 parts of eggplant peel; 5 parts of mulberry twigs; 5 parts of chestnut leaves; 3 parts of Doypro; 3 parts of abalone shell; 1.5 parts of fructus gleditsiae; calcined oyster 1.5 parts; 1 part of shrubalthea bark and 2 parts of transdermal enhancer.
Wherein the skin penetration enhancer comprises wintergreen oil 40 wt%, eucalyptus oil 50 wt%, glycerin 7 wt% and tetradecanol 3 wt%.
The raw material components are ground into powder with the particle size of 100 mu m, and then the softened scar patch is prepared after ethanol impregnation, extraction and filtration.
In the scheme, the powder is dynamically extracted by adopting 90 wt% of ethanol, and the volume of the 90 wt% of ethanol is 5 times that of the powder.
Example 2
A traditional Chinese medicine patch for softening scars comprises the following raw material components in parts by weight: 20 parts of orange peel; 15 parts of common clubmoss herb; 15 parts of eggplant peel; 12 parts of mulberry twigs; 12 parts of chestnut leaves; 10 portions of Doypyru; 8 parts of abalone shell; 5 parts of fructus gleditsiae; 5 parts of calcined oyster; 3 parts of shrubalthea bark and 6 parts of transdermal enhancer.
Wherein the skin penetration enhancer comprises 60 wt% of wintergreen oil, 35 wt% of eucalyptus oil, 3 wt% of glycerin and 2 wt% of tetradecanol.
The raw material components are ground into powder with the particle size of 500 mu m, and then the softened scar patch is prepared after ethanol impregnation, extraction and filtration.
In the scheme, the powder is dynamically extracted by adopting 90 wt% of ethanol, and the volume of the 90 wt% of ethanol is 8 times that of the powder.
Example 3
A traditional Chinese medicine patch for softening scars comprises the following raw material components in parts by weight: 15 parts of orange peel; 12 parts of common clubmoss herb; 12 parts of eggplant peel; 9 parts of mulberry twigs; 9 parts of chestnut leaves; 7 parts of polyethyl; 5 parts of abalone shell; 3 parts of fructus gleditsiae; 3 parts of calcined oyster; 2 parts of shrubalthea bark and 4 parts of transdermal enhancer.
Wherein the skin penetration enhancer comprises 50 wt% of wintergreen oil, 42 wt% of eucalyptus oil, 5 wt% of glycerin and 3 wt% of tetradecanol.
The raw material components are ground into powder with the particle size of 300 mu m, and then the softened scar patch is prepared after ethanol impregnation, extraction and filtration.
In the scheme, the powder is dynamically extracted by adopting 90 wt% of ethanol, and the volume of the 90 wt% of ethanol is 6 times that of the powder.
Example 4
A traditional Chinese medicine patch for softening scars comprises the following raw material components in parts by weight: 12 parts of orange peel; 11 parts of common clubmoss herb; 11 parts of eggplant peel; 10 parts of mulberry twigs; 10 parts of chestnut leaves; 8 parts of Doypyr; 7 parts of abalone shell; 4 parts of fructus gleditsiae; 4 parts of calcined oyster; 2.5 parts of shrubalthea bark and 3 parts of transdermal enhancer.
Wherein the skin penetration enhancer comprises 45 wt% of wintergreen oil, 45 wt% of eucalyptus oil, 6 wt% of glycerin and 4 wt% of tetradecanol.
The raw material components are ground into powder with the particle size of 200 mu m, and then the softened scar patch is prepared after ethanol impregnation, extraction and filtration.
In the scheme, the powder is dynamically extracted by adopting 90 wt% of ethanol, and the volume of the 90 wt% of ethanol is 7 times that of the powder.
Example 5
A traditional Chinese medicine patch for softening scars comprises the following raw material components in parts by weight: 18 parts of orange peel; 14 parts of common clubmoss herb; 14 parts of eggplant peel; 6 parts of mulberry twigs; 6 parts of chestnut leaves; 5 parts of polyethyl; 5 parts of abalone shell; 2 parts of fructus gleditsiae; 2 parts of calcined oyster; 1.5 parts of shrubalthea bark and 5 parts of transdermal enhancer.
Wherein the skin penetration enhancer comprises 55 wt% of wintergreen oil, 35 wt% of eucalyptus oil, 6 wt% of glycerin and 4 wt% of tetradecanol.
The raw material components are ground into powder with the particle size of 400 mu m, and then the softened scar patch is prepared after ethanol impregnation, extraction and filtration.
In the scheme, the powder is dynamically extracted by adopting 90 wt% of ethanol, and the volume of the 90 wt% of ethanol is 7 times that of the powder.
To illustrate the effects of the present invention, the inventors provide comparative experiments as follows:
< comparative example 1>
When the traditional Chinese medicine patch for softening scars is prepared, a transdermal enhancer is not added, the rest parameters are completely the same as those in the example 2, and the process is also completely the same.
< comparative example 2>
In the preparation of the traditional Chinese medicine patch for softening scars, tetradecanol is not added, the rest parameters are completely the same as those in the example 3, and the process is also completely the same.
The treatment trials were performed on a nude mouse scar model using the above examples and comparative examples:
35 nude mouse scar models were selected and randomly divided into 7 groups, and the change of the wound surface area was observed after administration of the scar-softening Chinese medicinal patches prepared in the above examples and comparative examples, respectively. See table 1 for specific results.
TABLE 1 treatment results of the example and comparative nude mouse scar models
Comparative example 1 compared with the examples, the formulation of the traditional Chinese medicine patch does not contain a transdermal enhancer, and effective treatment concentration and treatment effect of the active ingredients of the traditional Chinese medicine which reach the body through the skin are difficult to achieve due to the resistance of the skin cuticle.
Compared with the example, in the formula of the traditional Chinese medicine patch, the tetradecanol is not added, so that the effect of softening and repairing scars of the prepared traditional Chinese medicine patch is obviously poor, and the tetradecanol can effectively promote the absorption of effective components of traditional Chinese medicines for softening scars.
The traditional Chinese medicine patch for softening scars provided by the invention can soften and degrade scar tissues, further repair and regenerate the injured skin at the scar positions, fade and repair scars, particularly old scars, and has an obvious effect, wherein the old scars are close to normal skin color.
While embodiments of the invention have been disclosed above, it is not limited to the applications listed in the description and the embodiments, which are fully applicable in all kinds of fields of application of the invention, and further modifications may readily be effected by those skilled in the art, so that the invention is not limited to the specific details without departing from the general concept defined by the claims and the scope of equivalents.
Claims (5)
1. A traditional Chinese medicine patch for softening scars is characterized in that the raw material medicines are as follows:
also comprises 2-6 parts of transdermal enhancer; the transdermal enhancer comprises wintergreen oil 40-60 wt%, eucalyptus oil 30-50 wt%, glycerin 3-7 wt% and tetradecanol 2-5 wt%.
2. The traditional Chinese medicine patch for softening scars as claimed in claim 1, wherein the raw material components are ground into powder, and then subjected to ethanol dipping, extraction and filtration to prepare the scar softening patch.
3. The traditional Chinese medicine patch for softening scars as claimed in claim 2, wherein the particle size of said powder is 100 to 500 μm, and said extraction is dynamic extraction.
4. The scar-softening traditional Chinese medicine patch according to claim 3 wherein the powder is dynamically extracted with 90 wt% ethanol.
5. The scar-softening traditional Chinese medicine patch according to claim 4, wherein in the dynamic extraction process, the 90 wt% ethanol is 5-8 times the volume of the powder.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/CN2017/108109 WO2019080114A1 (en) | 2017-10-27 | 2017-10-27 | Tcm patch for softening scars |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN108235684A CN108235684A (en) | 2018-06-29 |
| CN108235684B true CN108235684B (en) | 2021-04-09 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201780001811.5A Active CN108235684B (en) | 2017-10-27 | 2017-10-27 | Traditional Chinese medicine patch for softening scars |
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| Country | Link |
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| CN (1) | CN108235684B (en) |
| WO (1) | WO2019080114A1 (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113476343A (en) * | 2021-07-19 | 2021-10-08 | 丹东欣时代生物医药科技有限公司 | Scar repairing silicone cream |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1296056C (en) * | 2004-04-09 | 2007-01-24 | 吕佰明 | Scar-free brun medicinal agent |
| CN100350918C (en) * | 2004-05-24 | 2007-11-28 | 秦世朴 | Medicinal liquor for treating burns, scalds and skin disease |
| CN1294933C (en) * | 2004-08-04 | 2007-01-17 | 肖建勋 | Liquid for cleaning burn wound and its preparation process |
| CN101134053B (en) * | 2006-08-29 | 2011-04-27 | 黄斌 | Pharmaceutical composition capable of treating scald |
| CN101422585B (en) * | 2008-07-28 | 2010-05-12 | 海南碧凯药业有限公司 | Pharmaceutical use of medicine composition containing zedoary turmeric oil |
| CN101332249A (en) * | 2008-08-06 | 2008-12-31 | 鹿守芝 | Liquor for treating scalding and burning |
| CN102048839A (en) * | 2009-11-05 | 2011-05-11 | 天津太平洋制药有限公司 | External Chinese medicinal preparation for treating scald and burn and preparation method thereof |
| CN102389529B (en) * | 2011-11-22 | 2013-06-05 | 孟利生 | Medicament used for treating burns and scalds |
| CN103127340A (en) * | 2011-11-24 | 2013-06-05 | 湖北爱民制药有限公司 | Ointment for curing scald and burn |
| CN107158358A (en) * | 2017-07-10 | 2017-09-15 | 东北林业大学 | A kind of anti-trick rhagadia cream of hazelnut oil and preparation method thereof |
-
2017
- 2017-10-27 WO PCT/CN2017/108109 patent/WO2019080114A1/en active Application Filing
- 2017-10-27 CN CN201780001811.5A patent/CN108235684B/en active Active
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| WO2019080114A1 (en) | 2019-05-02 |
| CN108235684A (en) | 2018-06-29 |
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