CN114159500A - Hyaluronic acid essential oil composition for nourishing and repairing oral cavity and application thereof - Google Patents
Hyaluronic acid essential oil composition for nourishing and repairing oral cavity and application thereof Download PDFInfo
- Publication number
- CN114159500A CN114159500A CN202111416101.3A CN202111416101A CN114159500A CN 114159500 A CN114159500 A CN 114159500A CN 202111416101 A CN202111416101 A CN 202111416101A CN 114159500 A CN114159500 A CN 114159500A
- Authority
- CN
- China
- Prior art keywords
- hyaluronic acid
- essential oil
- extract
- oral
- repairing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 title claims abstract description 104
- 229920002674 hyaluronan Polymers 0.000 title claims abstract description 104
- 229960003160 hyaluronic acid Drugs 0.000 title claims abstract description 104
- 239000000341 volatile oil Substances 0.000 title claims abstract description 56
- 210000000214 mouth Anatomy 0.000 title claims abstract description 48
- 239000000203 mixture Substances 0.000 title claims abstract description 37
- 239000000284 extract Substances 0.000 claims abstract description 27
- 235000009008 Eriobotrya japonica Nutrition 0.000 claims abstract description 21
- LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 claims abstract description 12
- 235000006200 Glycyrrhiza glabra Nutrition 0.000 claims abstract description 11
- VTAJIXDZFCRWBR-UHFFFAOYSA-N Licoricesaponin B2 Natural products C1C(C2C(C3(CCC4(C)CCC(C)(CC4C3=CC2)C(O)=O)C)(C)CC2)(C)C2C(C)(C)CC1OC1OC(C(O)=O)C(O)C(O)C1OC1OC(C(O)=O)C(O)C(O)C1O VTAJIXDZFCRWBR-UHFFFAOYSA-N 0.000 claims abstract description 9
- LPLVUJXQOOQHMX-UHFFFAOYSA-N glycyrrhetinic acid glycoside Natural products C1CC(C2C(C3(CCC4(C)CCC(C)(CC4C3=CC2=O)C(O)=O)C)(C)CC2)(C)C2C(C)(C)C1OC1OC(C(O)=O)C(O)C(O)C1OC1OC(C(O)=O)C(O)C(O)C1O LPLVUJXQOOQHMX-UHFFFAOYSA-N 0.000 claims abstract description 9
- 239000001685 glycyrrhizic acid Substances 0.000 claims abstract description 9
- 229960004949 glycyrrhizic acid Drugs 0.000 claims abstract description 9
- UYRUBYNTXSDKQT-UHFFFAOYSA-N glycyrrhizic acid Natural products CC1(C)C(CCC2(C)C1CCC3(C)C2C(=O)C=C4C5CC(C)(CCC5(C)CCC34C)C(=O)O)OC6OC(C(O)C(O)C6OC7OC(O)C(O)C(O)C7C(=O)O)C(=O)O UYRUBYNTXSDKQT-UHFFFAOYSA-N 0.000 claims abstract description 9
- 235000019410 glycyrrhizin Nutrition 0.000 claims abstract description 9
- WYQVAPGDARQUBT-FGWHUCSPSA-N Madecassol Chemical compound O([C@@H]1[C@@H](CO)O[C@H]([C@@H]([C@H]1O)O)OC[C@H]1O[C@H]([C@@H]([C@@H](O)[C@@H]1O)O)OC(=O)[C@]12CC[C@H]([C@@H]([C@H]1C=1[C@@]([C@@]3(CC[C@H]4[C@](C)(CO)[C@@H](O)[C@H](O)C[C@]4(C)[C@H]3CC=1)C)(C)CC2)C)C)[C@@H]1O[C@@H](C)[C@H](O)[C@@H](O)[C@H]1O WYQVAPGDARQUBT-FGWHUCSPSA-N 0.000 claims abstract description 7
- WYQVAPGDARQUBT-XCWYDTOWSA-N asiaticoside Natural products O=C(O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO[C@H]2[C@H](O)[C@H](O)[C@H](O[C@H]3[C@H](O)[C@H](O)[C@@H](O)[C@H](C)O3)[C@@H](CO)O2)O1)[C@@]12[C@@H]([C@@H](C)[C@H](C)CC1)C=1[C@](C)([C@@]3(C)[C@@H]([C@@]4(C)[C@H]([C@@](CO)(C)[C@@H](O)[C@H](O)C4)CC3)CC=1)CC2 WYQVAPGDARQUBT-XCWYDTOWSA-N 0.000 claims abstract description 7
- 229940022757 asiaticoside Drugs 0.000 claims abstract description 7
- QCYLIQBVLZBPNK-UHFFFAOYSA-N asiaticoside A Natural products O1C(C(=O)C(C)C)=CC(C)C(C2(C(OC(C)=O)CC34C5)C)C1CC2(C)C3CCC(C1(C)C)C45CCC1OC1OCC(O)C(O)C1O QCYLIQBVLZBPNK-UHFFFAOYSA-N 0.000 claims abstract description 7
- 229930182470 glycoside Natural products 0.000 claims abstract description 6
- 150000002338 glycosides Chemical class 0.000 claims abstract description 6
- 244000061508 Eriobotrya japonica Species 0.000 claims abstract 7
- 239000000606 toothpaste Substances 0.000 claims description 34
- 229940034610 toothpaste Drugs 0.000 claims description 32
- 239000001649 glycyrrhiza glabra l. absolute Substances 0.000 claims description 15
- 235000020725 licorice root extract Nutrition 0.000 claims description 15
- 229940051810 licorice root extract Drugs 0.000 claims description 15
- 230000008439 repair process Effects 0.000 claims description 14
- 241000167550 Centella Species 0.000 claims description 11
- 229940059958 centella asiatica extract Drugs 0.000 claims description 10
- 239000013588 oral product Substances 0.000 claims description 9
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 9
- 241000202807 Glycyrrhiza Species 0.000 claims description 7
- 235000001453 Glycyrrhiza echinata Nutrition 0.000 claims description 7
- 235000017382 Glycyrrhiza lepidota Nutrition 0.000 claims description 7
- -1 glycyrrhiza polysaccharide Chemical class 0.000 claims description 7
- 229940010454 licorice Drugs 0.000 claims description 7
- 229940023486 oral product Drugs 0.000 claims description 7
- 229920001282 polysaccharide Polymers 0.000 claims description 7
- 239000005017 polysaccharide Substances 0.000 claims description 7
- 229930194248 Licoflavone Natural products 0.000 claims description 6
- MEHHCBRCXIDGKZ-UHFFFAOYSA-N Licoflavone C Natural products CC(C)=CCC1=C(O)C=C(O)C(C(C=2)=O)=C1OC=2C1=CC=C(O)C=C1 MEHHCBRCXIDGKZ-UHFFFAOYSA-N 0.000 claims description 6
- 240000007436 Cananga odorata Species 0.000 claims description 4
- 235000007866 Chamaemelum nobile Nutrition 0.000 claims description 4
- 244000042664 Matricaria chamomilla Species 0.000 claims description 4
- 235000007232 Matricaria chamomilla Nutrition 0.000 claims description 4
- 238000002360 preparation method Methods 0.000 claims description 4
- 239000002324 mouth wash Substances 0.000 claims description 3
- 229940051866 mouthwash Drugs 0.000 claims description 3
- 239000008213 purified water Substances 0.000 claims description 3
- 235000007571 Cananga odorata Nutrition 0.000 claims description 2
- 239000007921 spray Substances 0.000 claims description 2
- 239000011324 bead Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 16
- 244000303040 Glycyrrhiza glabra Species 0.000 abstract description 10
- 244000146462 Centella asiatica Species 0.000 abstract description 4
- 235000004032 Centella asiatica Nutrition 0.000 abstract description 4
- 239000000419 plant extract Substances 0.000 abstract description 4
- 150000003254 radicals Chemical class 0.000 abstract description 3
- 235000018142 Hedysarum alpinum var americanum Nutrition 0.000 abstract description 2
- 240000006461 Hedysarum alpinum var. americanum Species 0.000 abstract description 2
- 238000012377 drug delivery Methods 0.000 abstract description 2
- 230000002045 lasting effect Effects 0.000 abstract description 2
- 235000017443 Hedysarum boreale Nutrition 0.000 abstract 1
- 235000007858 Hedysarum occidentale Nutrition 0.000 abstract 1
- 239000001947 glycyrrhiza glabra rhizome/root Substances 0.000 abstract 1
- 230000003647 oxidation Effects 0.000 abstract 1
- 238000007254 oxidation reaction Methods 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 description 29
- 230000000052 comparative effect Effects 0.000 description 18
- 241001092070 Eriobotrya Species 0.000 description 14
- 230000003110 anti-inflammatory effect Effects 0.000 description 11
- 238000012360 testing method Methods 0.000 description 11
- 108090001005 Interleukin-6 Proteins 0.000 description 9
- 230000036541 health Effects 0.000 description 9
- 239000000047 product Substances 0.000 description 9
- 239000003814 drug Substances 0.000 description 8
- 230000000844 anti-bacterial effect Effects 0.000 description 7
- 238000004140 cleaning Methods 0.000 description 7
- 238000001514 detection method Methods 0.000 description 6
- 230000006870 function Effects 0.000 description 6
- 239000013642 negative control Substances 0.000 description 6
- 238000004458 analytical method Methods 0.000 description 5
- 229940079593 drug Drugs 0.000 description 5
- 239000006072 paste Substances 0.000 description 5
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 4
- 230000003385 bacteriostatic effect Effects 0.000 description 4
- 230000000975 bioactive effect Effects 0.000 description 4
- 239000002537 cosmetic Substances 0.000 description 4
- 230000003020 moisturizing effect Effects 0.000 description 4
- 210000004400 mucous membrane Anatomy 0.000 description 4
- 238000011160 research Methods 0.000 description 4
- 210000003296 saliva Anatomy 0.000 description 4
- 230000028327 secretion Effects 0.000 description 4
- 239000000725 suspension Substances 0.000 description 4
- 208000024891 symptom Diseases 0.000 description 4
- 230000008901 benefit Effects 0.000 description 3
- 150000001875 compounds Chemical class 0.000 description 3
- UREBDLICKHMUKA-CXSFZGCWSA-N dexamethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O UREBDLICKHMUKA-CXSFZGCWSA-N 0.000 description 3
- 229960003957 dexamethasone Drugs 0.000 description 3
- 238000011156 evaluation Methods 0.000 description 3
- 238000007689 inspection Methods 0.000 description 3
- 235000011477 liquorice Nutrition 0.000 description 3
- 230000004060 metabolic process Effects 0.000 description 3
- 210000002200 mouth mucosa Anatomy 0.000 description 3
- 150000003839 salts Chemical class 0.000 description 3
- 230000000638 stimulation Effects 0.000 description 3
- 230000002195 synergetic effect Effects 0.000 description 3
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
- 229920002683 Glycosaminoglycan Polymers 0.000 description 2
- 206010020751 Hypersensitivity Diseases 0.000 description 2
- 206010061218 Inflammation Diseases 0.000 description 2
- 208000026935 allergic disease Diseases 0.000 description 2
- 239000003242 anti bacterial agent Substances 0.000 description 2
- 230000003266 anti-allergic effect Effects 0.000 description 2
- 230000005549 barrier dysfunction Effects 0.000 description 2
- 230000004888 barrier function Effects 0.000 description 2
- 230000000740 bleeding effect Effects 0.000 description 2
- 238000013329 compounding Methods 0.000 description 2
- 230000007547 defect Effects 0.000 description 2
- 210000002919 epithelial cell Anatomy 0.000 description 2
- 235000013305 food Nutrition 0.000 description 2
- 239000003906 humectant Substances 0.000 description 2
- 230000006872 improvement Effects 0.000 description 2
- 238000000338 in vitro Methods 0.000 description 2
- 230000004054 inflammatory process Effects 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 235000016709 nutrition Nutrition 0.000 description 2
- 230000035764 nutrition Effects 0.000 description 2
- 239000012466 permeate Substances 0.000 description 2
- 230000002265 prevention Effects 0.000 description 2
- 239000006041 probiotic Substances 0.000 description 2
- 235000018291 probiotics Nutrition 0.000 description 2
- 230000001737 promoting effect Effects 0.000 description 2
- 235000017557 sodium bicarbonate Nutrition 0.000 description 2
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 2
- 239000002689 soil Substances 0.000 description 2
- 206010006326 Breath odour Diseases 0.000 description 1
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 description 1
- 208000034619 Gingival inflammation Diseases 0.000 description 1
- 208000032139 Halitosis Diseases 0.000 description 1
- 206010019233 Headaches Diseases 0.000 description 1
- 241000590002 Helicobacter pylori Species 0.000 description 1
- 208000032843 Hemorrhage Diseases 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- OVRNDRQMDRJTHS-UHFFFAOYSA-N N-acelyl-D-glucosamine Natural products CC(=O)NC1C(O)OC(CO)C(O)C1O OVRNDRQMDRJTHS-UHFFFAOYSA-N 0.000 description 1
- OVRNDRQMDRJTHS-FMDGEEDCSA-N N-acetyl-beta-D-glucosamine Chemical group CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O OVRNDRQMDRJTHS-FMDGEEDCSA-N 0.000 description 1
- MBLBDJOUHNCFQT-LXGUWJNJSA-N N-acetylglucosamine Natural products CC(=O)N[C@@H](C=O)[C@@H](O)[C@H](O)[C@H](O)CO MBLBDJOUHNCFQT-LXGUWJNJSA-N 0.000 description 1
- 241000605862 Porphyromonas gingivalis Species 0.000 description 1
- 230000002292 Radical scavenging effect Effects 0.000 description 1
- GAMYVSCDDLXAQW-AOIWZFSPSA-N Thermopsosid Natural products O(C)c1c(O)ccc(C=2Oc3c(c(O)cc(O[C@H]4[C@H](O)[C@@H](O)[C@H](O)[C@H](CO)O4)c3)C(=O)C=2)c1 GAMYVSCDDLXAQW-AOIWZFSPSA-N 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 230000007815 allergy Effects 0.000 description 1
- 210000003484 anatomy Anatomy 0.000 description 1
- 230000003501 anti-edematous effect Effects 0.000 description 1
- 230000002924 anti-infective effect Effects 0.000 description 1
- 230000003064 anti-oxidating effect Effects 0.000 description 1
- 239000011668 ascorbic acid Substances 0.000 description 1
- 229960005070 ascorbic acid Drugs 0.000 description 1
- 235000010323 ascorbic acid Nutrition 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 244000052616 bacterial pathogen Species 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 229910002056 binary alloy Inorganic materials 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 208000034158 bleeding Diseases 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 230000001680 brushing effect Effects 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 230000005779 cell damage Effects 0.000 description 1
- 208000037887 cell injury Diseases 0.000 description 1
- 230000003833 cell viability Effects 0.000 description 1
- 238000003570 cell viability assay Methods 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 239000012459 cleaning agent Substances 0.000 description 1
- 235000009508 confectionery Nutrition 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 208000002925 dental caries Diseases 0.000 description 1
- 210000003298 dental enamel Anatomy 0.000 description 1
- 210000004207 dermis Anatomy 0.000 description 1
- 238000000586 desensitisation Methods 0.000 description 1
- 230000000249 desinfective effect Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- MGJZITXUQXWAKY-UHFFFAOYSA-N diphenyl-(2,4,6-trinitrophenyl)iminoazanium Chemical compound [O-][N+](=O)C1=CC([N+](=O)[O-])=CC([N+]([O-])=O)=C1N=[N+](C=1C=CC=CC=1)C1=CC=CC=C1 MGJZITXUQXWAKY-UHFFFAOYSA-N 0.000 description 1
- HHEAADYXPMHMCT-UHFFFAOYSA-N dpph Chemical compound [O-][N+](=O)C1=CC([N+](=O)[O-])=CC([N+]([O-])=O)=C1[N]N(C=1C=CC=CC=1)C1=CC=CC=C1 HHEAADYXPMHMCT-UHFFFAOYSA-N 0.000 description 1
- 206010013781 dry mouth Diseases 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 229930003944 flavone Natural products 0.000 description 1
- 150000002212 flavone derivatives Chemical class 0.000 description 1
- 235000011949 flavones Nutrition 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 229910052731 fluorine Inorganic materials 0.000 description 1
- 239000011737 fluorine Substances 0.000 description 1
- 239000006260 foam Substances 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 208000007565 gingivitis Diseases 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 235000011187 glycerol Nutrition 0.000 description 1
- 231100000869 headache Toxicity 0.000 description 1
- 229940037467 helicobacter pylori Drugs 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 230000002757 inflammatory effect Effects 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 230000005923 long-lasting effect Effects 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 230000001050 lubricating effect Effects 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000000813 microbial effect Effects 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 210000004877 mucosa Anatomy 0.000 description 1
- 210000003550 mucous cell Anatomy 0.000 description 1
- 229950006780 n-acetylglucosamine Drugs 0.000 description 1
- 210000003300 oropharynx Anatomy 0.000 description 1
- 230000003204 osmotic effect Effects 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 230000003239 periodontal effect Effects 0.000 description 1
- 201000001245 periodontitis Diseases 0.000 description 1
- 230000035790 physiological processes and functions Effects 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 239000013641 positive control Substances 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 238000004445 quantitative analysis Methods 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 210000003491 skin Anatomy 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 208000003265 stomatitis Diseases 0.000 description 1
- 238000005728 strengthening Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 230000004083 survival effect Effects 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 230000007838 tissue remodeling Effects 0.000 description 1
- 208000004371 toothache Diseases 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- WGIWBXUNRXCYRA-UHFFFAOYSA-H trizinc;2-hydroxypropane-1,2,3-tricarboxylate Chemical compound [Zn+2].[Zn+2].[Zn+2].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O WGIWBXUNRXCYRA-UHFFFAOYSA-H 0.000 description 1
- 238000012795 verification Methods 0.000 description 1
- VHBFFQKBGNRLFZ-UHFFFAOYSA-N vitamin p Natural products O1C2=CC=CC=C2C(=O)C=C1C1=CC=CC=C1 VHBFFQKBGNRLFZ-UHFFFAOYSA-N 0.000 description 1
- 230000002087 whitening effect Effects 0.000 description 1
- 230000029663 wound healing Effects 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
- 239000011746 zinc citrate Substances 0.000 description 1
- 235000006076 zinc citrate Nutrition 0.000 description 1
- 229940068475 zinc citrate Drugs 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Alternative & Traditional Medicine (AREA)
- Medical Informatics (AREA)
- Birds (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Inorganic Chemistry (AREA)
- Cosmetics (AREA)
Abstract
The invention discloses a hyaluronic acid essential oil composition for nourishing and repairing oral cavity and application thereof; the composition comprises hyaluronic acid, essential oil, licorice root, loquat leaf and centella asiatica extracts, wherein the hyaluronic acid is hyaluronic acid with the mass ratio of 1: 4-5: 3-4 and above 120kDa, hyaluronic acid with the mass ratio of 80-120kDa and hyaluronic acid with the mass ratio of 1-80 kDa. The composition is used for preparing oral cavity repairing product. The invention selects hyaluronic acid with proper molecular weight and plant extracts of hyaluronic acid, liquorice root, asiatic pennywort herb and the like with scientific proportion to be extracted; more importantly, the HA is used as a carrier for drug delivery, multiple target points of glycyrrhizic acid, loquat leaf glycoside, asiaticoside and the like are promoted to act on cells and cells, and the effects of oxidation resistance, free radical resistance, cell nourishing, repairing and the like are achieved; thereby creating a good and lasting microenvironment for the oral cavity.
Description
Technical Field
The invention relates to a hyaluronic acid essential oil composition for nourishing and repairing oral cavity and application thereof.
Background
With the improvement of living standard, people pay more and more attention to oral hygiene, oral health care and oral health, and have relied on toothpaste as a cleaning product in daily life. Toothpaste can remove stains and bacterial plaques on the surfaces of teeth, has no stimulation and toxicity on oral mucosa, and is very important for oral cavity cleaning and oral cavity health care, but only the toothpaste is used. The root of common oral problems such as gingivitis, oropharynx, oral mucositis and the like is the restoration of oral micro-damage after a long time. To address these oral problems, an oral care product must be selected that is effective in repairing the micro-lesions of the oral cavity. Most of the toothpaste in the current market is mainly clean, and other health-care toothpastes with different efficacies are: the traditional Chinese medicine composition has the advantages of preventing caries by adding fluorine, resisting allergy by adding zinc, stopping bleeding by adding a white medicine, disinfecting and resisting bacteria, treating headache, mainly treating symptoms by applying medicines according to symptoms, being difficult to persist and fundamentally determining.
Most toothpaste formulations today are generally only concerned with cleaning alone, or with problems with the teeth alone; but ignores: toothache, bleeding, halitosis, periodontitis and other symptoms are not only problems of teeth, but also problems of oral barrier and mucosal cell damage and defects. If compare the tooth and the tree, the oral cavity is soil and is taken down earth greatly promptly. Trees need to be kept branches and cleaned, but more importantly, the teeth and the trees have the same effect of absorbing various nutrition and growth and development factors from soil. The microenvironment of the oral cavity is poor, so that the probability of a series of problems of the teeth is certainly greatly improved. Therefore, the invention provides a moisturizing and cleaning binary system formula of oral products such as toothpaste, mouthwash and the like, which comprises the following components in parts by weight: a scheme for strengthening body resistance to eliminate pathogenic factors, protecting good micro-ecology of the oral cavity and repairing micro-damage of the oral cavity; moisturizing is performed from each cell in the oral cavity; the flow of water among cells is accelerated, nutrition is conveyed, information is transmitted, metabolism is promoted, the self-repairing capability of the cells is promoted, the creation and repair of the mouth microenvironment are enhanced by the healthy and active cells, and the problems of the mouth and teeth can be avoided fundamentally by the healthy and active cells.
Hyaluronic Acid (HA) is an acidic mucopolysaccharide, an unbranched macromolecular glycosaminoglycan composed of repeating units of N-acetylglucosamine and D-glucuronosyl, present in the stroma of animal tissues and in the capsule of certain bacteria. Hyaluronic acid is widely used in the fields of medicines, cosmetics, foods and the like. Hyaluronic acid has a number of physiological functions, such as anti-inflammatory, anti-infective, anti-edema, tissue remodeling and wound healing, in addition to its functions of retaining water, lubricating, regulating osmotic pressure, etc. With the intensive research and the accumulation of clinical experience, HA HAs many new application fields, wherein the application of HA in the oral cavity field HAs been gradually noticed.
In the prior art, oral care products containing much hyaluronic acid are available, for example, CN 106420493 a discloses a hyaluronic acid toothpaste with anti-inflammatory and antibacterial effects and a preparation method thereof, which utilizes the anti-inflammatory and antibacterial effects of hyaluronic acid, and ascorbic acid and composition fluid extract which have synergistic, anti-inflammatory and antibacterial effects with hyaluronic acid, so as to have better anti-inflammatory and antibacterial effects. CN 104666112 a discloses a bioactive hyaluronic acid toothpaste; the toothpaste accessory thickener sorbitol and the bioactive hyaluronic acid synergistically enhance the anti-inflammatory effect of the bioactive hyaluronic acid. CN107536725A discloses a multi-effect oral composition containing a hyaluronic acid mixture and an application thereof, the invention compounds hyaluronic acid with low molecular weight and hyaluronic acid with high molecular weight to form a mixture, and the mixture has a function compounding effect, the hyaluronic acid with low molecular weight has a good mucous membrane repairing effect, the hyaluronic acid with high molecular weight has a good mucous membrane anti-inflammatory effect, and the hyaluronic acid mixture and zinc citrate are compounded to play a synergistic bacteriostasis effect, inhibit oral pathogenic bacteria and achieve the effect of maintaining oral health. The patent technologies all utilize the anti-inflammatory and bacteriostatic effects of hyaluronic acid. For another example, CN112618389A discloses a baking soda whitening toothpaste containing hyaluronic acid and a preparation method thereof, wherein the compound hyaluronic acid or salt thereof is formed by compounding high and medium molecular weight and oligomeric hyaluronic acid or salt thereof, and the compound hyaluronic acid or salt thereof can alleviate the adverse effects of enamel damage, gingival inflammation and the like caused by long-term use of the baking soda toothpaste, and reduce the formation of sensitive teeth.
The survival period of the human oral cells is only 14 days, and the cells are updated at a speed of about 7 percent per day, so that the cells can provide good habitat for the new cells and repair the new cells in time, and the cells are key to oral health. However, neither the above-mentioned patent techniques nor the prior art relate to nor enable the creation of a good microenvironment of the mouth.
Disclosure of Invention
Aiming at the defects in the prior art, the invention provides a hyaluronic acid essential oil composition for nourishing and repairing the oral cavity and application thereof. The invention selects hyaluronic acid with proper molecular weight and plant extracts of hyaluronic acid, liquorice root, loquat leaf, asiatic pennywort herb and the like with scientific proportion to be extracted; the HA not only utilizes the moisturizing, anti-inflammatory and bacteriostatic effects, but also plays a more important role in drug delivery by taking the HA as a carrier, so that the drugs permeate into the dermis, multiple target points of glycyrrhizic acid, loquat leaf glycoside, asiaticoside and the like are promoted to act between cells, the effects of antioxidation, free radical resistance, cell repair and the like are fully played, the hyaluronic acid and plant extract advantages are mutually supplemented, the synergistic effect is achieved, and a good and lasting oral microenvironment is further created.
The purpose of the invention is realized by the following technical scheme:
the invention provides a hyaluronic acid essential oil oral care composition, which contains hyaluronic acid, essential oil, a licorice root extract, a loquat leaf extract and a centella extract.
The hyaluronic acid, the licorice root extract, the loquat leaf extract and the centella asiatica extract in the composition are all food grade, and the mass ratio of the hyaluronic acid, the licorice root extract, the loquat leaf extract and the centella asiatica extract is (0.01-1): (0.01-0.5): (0.01-0.3). Preferably 0.2:0.25:0.1: 0.05.
According to one embodiment of the invention, the hyaluronic acid is selected from high molecular weight hyaluronic acid, medium molecular weight hyaluronic acid and low molecular weight hyaluronic acid with a mass ratio of 1: 4-5: 3-4.
The molecular weight of the high molecular weight hyaluronic acid is more than 120 kDa.
The molecular weight of the hyaluronic acid with the medium molecular weight is 80-120 kDa.
The molecular weight of the low molecular weight hyaluronic acid is 1-80 kDa.
As one embodiment of the present invention, the glycyrrhizic acid content in the licorice root extract is 55-75%; the content of asiaticoside in the centella extract is 50-70%; the content of loquat glycoside in the loquat leaf extract is 20-50%. In some embodiments, the centella asiatica extract contains 60% of centella asiatica sweet.
As an embodiment of the present invention, the licorice root extract further contains licoflavone and glycyrrhiza polysaccharide. The Glycyrrhrizae radix extract contains 2-5% of licoflavone and 8-12% of Glycyrrhiza polysaccharide. In some embodiments, the licorice root extract has a glycyrrhizic acid content of 65%, a licorice flavone content of 3%, and a licorice polysaccharide content of 10%.
As an embodiment of the present invention, the mass ratio of the essential oil to the hyaluronic acid is: (0.03-0.6):(0.01-1).
As an embodiment of the present invention, the essential oil is a combination of multiple of licorice essential oil, centella essential oil, chamomile essential oil, ylang-ylang essential oil. The licorice essential oil can also be derived from licorice root extract; the centella essential oil can be derived from centella asiatica extract.
The invention also relates to application of the hyaluronic acid essential oil nourishing and repairing composition for the oral cavity in preparation of an oral product.
As an embodiment of the present invention, the oral product has hyaluronic acid content of 0.01-1 wt%, licorice root extract content of 0.01-1 wt%, loquat leaf extract content of 0.01-0.5 wt%, and centella asiatica extract content of 0.01-0.3 wt%.
As an embodiment of the invention, the content of essential oils in the oral product is 0.03-0.6 wt%. Preferably 0.3 to 0.6 wt%.
As an embodiment of the present invention, the oral product comprises a restorative toothpaste, mouthwash, mouth restorative gel, mouth spray, mouth freshener, or pop sugar.
The invention also relates to hyaluronic acid essential oil nourishing and repairing toothpaste which comprises the following components in percentage by weight:
and the balance purified water. In some embodiments, the purified water is present in the toothpaste in an amount of 20 to 50 wt%, preferably 24% to 45%.
As an embodiment of the present invention, the essential oil is a combination of multiple of licorice essential oil, centella essential oil, chamomile essential oil, ylang-ylang essential oil. Preferably 0.3 wt% essential oil. The preferred essential oil composition is in a mass ratio of 1:1:0.5: 0.5. The oral cavity is a habitat with higher flowing frequency, and the essential oil in the proportion is favorable for fast adsorption and permeation into gum and mucosal tissues, so that the efficacy of the essential oil is exerted persistently and effectively.
Three basic elements of oral hygiene: cleaning, moisturizing, nourishing and repairing. The human oral cavity has its own system of cleaning and moisture preservation, relating to the theory of anatomy, oral biology and human immunology. The oral cavity is an important inlet and outlet channel of a human body, and the oral cavity micro-ecology is formed by the human body and microorganisms, so that each cell of the oral cavity can be normally metabolized and moved, and the health of the oral cavity is maintained. Oral health maintenance requires less employment of agents such as antibacterial agents, and relies on the powerful repair capabilities of cells and probiotics themselves. While clean, moist, fresh breath are oral health signs.
Compared with the prior art, the invention has the following beneficial effects:
1) different from glycerin, hyaluronic acid is a substance of a human body, and is reasonably applied to supplement the blank that the secretion of the human body is reduced along with the age, oral epithelial cells and skin need hyaluronic acid to absorb water and preserve moisture, the metabolism of the cells is kept, the moistening of oral mucosa is kept, and the repair function of an oral barrier is protected; after being applied for a few days, the oral cavity sub-health symptoms such as dry mouth, greasy mouth, breath and the like are obviously relieved and disappeared, the oral mucosa of the gum is ruddy, semitransparent and elastic, and the breath is fresh and long-lasting.
2) The invention has no antibacterial agent component, and aims to protect probiotics and maintain oral micro-ecology; by means of the function of HA as a carrier for transferring drugs, factors such as liquorice, centella and the like enter a cell basal layer through epithelial cells, and the functions are better played. In addition, the liquorice has the function of promoting the secretion of saliva by promoting the production of body fluid and removing blood stasis; saliva is rich in HA, peptide, enzyme and the like, and is the best cleaning humectant for human bodies; before the application of the product: the mouth cleaning agent can be used for brushing dry teeth, toothpaste paste dry bodies and dry oral cavities without mouth rinsing, after teeth are brushed for several seconds, people feel that a large amount of saliva is secreted, the whole oral cavity is filled with foams, namely, the liquorice promotes the secretion of saliva and promotes metabolism, the hyaluronic acid locks moisture, and the plant extract is accompanied with micromolecular HA to enter various mucous membranes and cells of the oral cavity to repair the micro-damage of the oral cavity; the cells are healthy, the oral cavity is also healthy, the gum, the periodontal and the teeth are healthier, and a green oral ecology is created.
3) The invention provides a new choice for multi-target repairing oral cell and oral health by using the humectant and bioactive components aiming at oral micro-injury, such as immunity, microbial balance and the like; the oral cavity barrier dysfunction and the oral cavity sub-health state can be solved from different angles, and the oral cavity barrier dysfunction prevention method belongs to the field of good oral cavity prevention learning prospect.
Drawings
Other features, objects and advantages of the invention will become more apparent upon reading of the detailed description of non-limiting embodiments with reference to the following drawings:
FIG. 1 is a schematic diagram showing the analysis of the cell viability assay results of the product of example 5; wherein, (a) is a data list, and (b) is a histogram;
FIG. 2 is the raw data of IL-6 content measurement of the product of example 5;
FIG. 3 is a standard curve graph;
FIG. 4 is a graphical representation of the effect of toothpaste of example 5 on IL-6 levels.
Detailed Description
The present invention will be described in detail with reference to examples. The following examples will assist those skilled in the art in further understanding the invention, but are not intended to limit the invention in any way. It should be noted that it would be apparent to those skilled in the art that several modifications and improvements can be made without departing from the inventive concept. All falling within the scope of the present invention.
In the hyaluronic acid essential oil repairing oral composition, the mass ratio of hyaluronic acid to licorice root extract to loquat leaf extract to centella asiatica extract is (0.01-1) to (0.01-1): (0.01-0.5): (0.01-0.3). The composition is specifically applied to oral products, and comprises 0.01-1 wt% of hyaluronic acid, 0.01-1 wt% of licorice root extract, 0.01-0.5 wt% of loquat leaf extract, 0.01-0.3 wt% of centella asiatica extract and 0.1-0.6 wt% of essential oil. The invention realizes the construction of good mouth microenvironment by hyaluronic acid with proper molecular weight and hyaluronic acid, glycyrrhizic acid and asiaticoside with scientific proportion. Wherein the hyaluronic acid is selected from 120kDa hyaluronic acid, 80-100kDa hyaluronic acid and 1-60kDa hyaluronic acid with the mass ratio of 1: 4-5: 3-4. The polymer HA covers the cells, locks water and preserves moisture, forms a warm-wet effect for the cells under mucosa, and the medium and small molecular HA can permeate into different layers and different depths to play a role in transferring carrier drugs and promote glycyrrhizic acid, loquat leaf glycoside, asiaticoside and the like to fully play a role in the cells.
The specific application is detailed in the following examples:
examples 1 to 5
Examples 1 to 5 relate to hyaluronic acid essential oil repair toothpaste, the composition of which is shown in table 1; wherein the Glycyrrhrizae radix extract contains glycyrrhizic acid, licoflavone and Glycyrrhiza polysaccharide, and wherein glycyrrhizic acid content is 65%, licoflavone content is 3%, and Glycyrrhiza polysaccharide content is 12%; the content of asiaticoside in the centella extract is 60%; the content of loquat glycoside in the loquat leaf extract is 40%. The essential oil comprises licorice essential oil, centella essential oil, chamomile essential oil and cananga odorata essential oil in a mass ratio of 1:1:0.5: 0.5.
Comparative example 1
Comparative example 1 relates to a repair toothpaste having the composition shown in table 1; it differs from example 5 only in that: the oral care composition is free of hyaluronic acid essential oil, and is free of hyaluronic acid, essential oil, Glycyrrhrizae radix extract, folium Eriobotryae extract and herba Centellae extract.
Comparative example 2
Comparative example 2 relates to a hyaluronic acid essential oil repair toothpaste, the composition of which is shown in table 1; it differs from example 5 only in that: it does not contain Glycyrrhrizae radix extract.
Comparative example 3
Comparative example 3 relates to a hyaluronic acid essential oil repair toothpaste, the composition of which is shown in table 1; it differs from example 5 only in that: it does not contain centella asiatica extract.
Comparative example 4
Comparative example 4 relates to a hyaluronic acid essential oil repair toothpaste, the composition of which is shown in table 1; it differs from example 5 only in that: it does not contain loquat leaf extract.
Comparative example 5
Comparative example 5 relates to a hyaluronic acid essential oil repair toothpaste, the composition of which is shown in table 1; it differs from example 5 in that: all hyaluronic acid was selected as 100kDa HA.
TABLE 1
Verification example
1. Water retention detection
The products of each example and comparative example are sent to the cosmetic technology center of the Chinese inspection and quarantine scientific research institute for water retention rate detection. The raw weights of the toothpastes of the examples and comparative examples were measured and the corresponding weights were recorded after 2, 4, 6, 8, 10, 12, 24, 36, 48, 72, 96 hours, converted to water retention rates of the examples and comparative examples, as shown in table 2 below:
results analysis of relative Water Retention (%) for samples of Table 2, examples and comparative examples
As can be seen from the analysis of the relative water retention results in Table 2, the water retention time of the product in example 5 is obviously increased by 103% from 29.8% to 60.7% compared with that in comparative example 1 after 8 hours; increased by 251% in 10 hours; the increase was 23.8 times for 12 hours. In addition, comparative example 5 HAs HA, but the moisture-keeping effect is not good when the mixture ratio is not proper.
2. Antibacterial testing (suspension quantitative method)
The products of each embodiment and the comparative example are sent to the cosmetic technical center of China inspection and quarantine scientific research institute for antibacterial detection, and the detection and evaluation are based on WS/T650-plus 2019 antibacterial and bacteriostatic effect evaluation method; the test was repeated three times under the test conditions; the 40% concentration sample toothpaste (suspension) acted on porphyromonas gingivalis for 3min (the 40% concentration suspension is prepared from toothpaste paste and water 1: 2, the proportion of the paste is 1.15, the concentration is 39.8%), the average value of each bacteriostasis rate is shown in the following table 2: the test is repeated three times under the condition of 20 +/-1 ℃; the 40% sample toothpaste (suspension) acts on helicobacter pylori for 3min, and the average value of each bacteriostasis rate is shown in the following table 3 (more than 90%, the toothpaste is judged to have strong bacteriostasis):
bacteriostatic ratio (%)
3. Anti-free radical test: the effect of obviously removing DPPH free radicals is achieved when the test concentration of each example and each comparative example is more than 12.5 percent according to the condition that the paste is 100 percent; the results are given in table 4 below:
TABLE 4 DPPH radical scavenging test
In table 4, the control refers to a blank, i.e., a commercial toothpaste of ten dollars or less.
4. Anti-inflammatory and anti-allergic efficacy was evaluated in vitro (IL-6), and dexamethasone was used as a negative control.
The example 5 is sent to the cosmetic technology center of the Chinese inspection and quarantine science research institute for in vitro anti-inflammatory and allergy-relieving efficacy evaluation experiment, and the analysis of the cell viability detection result (action 24h) is shown in figure 1; wherein, the HA concentration of the paste is 100 percent, and the concentration is converted into the test concentration; example 5 toothpaste containing 0.8% hyaluronic acid, i.e. 1g of toothpaste containing 8mg HA, was diluted with water to HA concentrations as shown in FIG. 1(a), respectively.
FIG. 2 is the raw data of IL-6 content measurement, the standard curve is shown in FIG. 3, and the analysis of the test results is shown in FIG. 4:
considering that the control group and the test group are separately arranged for biological cell detection, the control component is negative control, namely no stimulation and no medicine addition are carried out, and the model control makes the negative control cells have inflammation stimulation. Positive control negative control cells were stimulated for inflammation and dexamethasone was added. The comparison shows that the sample group is superior to the positive group, and the effect is better than that of dexamethasone.
FIG. 4 is a graph of the effect of toothpaste of example 5 on IL-6 levels, # # vs. negative control, p < 0.01; comparing with model control, p is less than 0.01. Compared with a negative control group, the secretion level of the inflammatory factor IL-6 of the model control group is obviously increased (p is less than 0.01), which indicates that the modeling is successful, and the model can be used for evaluating the desensitization effect of the test object. Compared with a model control group, the IL-6 release amount is not reduced after the HOEC cells act on the samples with the concentration of 0.16mg/ml and 0.31 mg/ml; the samples at a concentration of 0.08mg/ml had a statistically significant (p < 0.01) decrease in IL-6 release after HOEC cells were treated. Example 5 at a concentration of 0.08mg/ml, the release amount of IL-6 secreted by HOEC cells induced by IFN-y and LPS together can be remarkably reduced, and the slow repair effect on mucosal cells is shown.
The foregoing description of specific embodiments of the present invention has been presented. It is to be understood that the present invention is not limited to the specific embodiments described above, and that various changes and modifications may be made by one skilled in the art within the scope of the appended claims without departing from the spirit of the invention.
Claims (10)
1. A hyaluronic acid essential oil composition for nourishing and repairing oral cavity, which is characterized by comprising hyaluronic acid, essential oil, licorice root extract, loquat leaf extract and centella extract.
2. The hyaluronic acid essential oil nourishment and restoration oral composition according to claim 1, wherein the mass ratio of hyaluronic acid, licorice root extract, loquat leaf extract and centella asiatica extract in the composition is (0.01-1) to (0.01-1): (0.01-0.5): (0.01-0.3).
3. The hyaluronic acid essential oil nourishing and repairing composition for the oral cavity as claimed in claim 1, wherein the hyaluronic acid is hyaluronic acid with a mass ratio of 1: 4-5: 3-4 and above 120kDa, hyaluronic acid with a mass ratio of 80-120kDa and hyaluronic acid with a mass ratio of 1-80 kDa.
4. The hyaluronic acid essential oil nourishment and restoration oral composition according to claim 1, wherein the glycyrrhizic acid content in the licorice root extract is 55-75%; the content of asiaticoside in the centella extract is 50-70%; the content of loquat glycoside in the loquat leaf extract is 20-50%.
5. The hyaluronic acid essential oil nourishment and restoration oral composition according to claim 4, wherein the licorice root extract further comprises licoflavone and glycyrrhiza polysaccharide; the Glycyrrhrizae radix extract contains 2-5% of licoflavone and 8-12% of Glycyrrhiza polysaccharide.
6. The hyaluronic acid essential oil nourishing and restoring oral composition as defined in claim 1, wherein the mass ratio of hyaluronic acid to hyaluronic acid is (0.03-0.6): (0.01-1); the essential oil is a combination of multiple of licorice essential oil, centella essential oil, chamomile essential oil and cananga odorata essential oil.
7. Use of a hyaluronic acid essential oil trophy-repairing oral composition according to any of claims 1-6, for the preparation of an oral product.
8. Use according to claim 7, characterized in that the content of hyaluronic acid in the oral product is between 0.01 and 1 wt%, the content of licorice root extract is between 0.01 and 1 wt%, the content of loquat leaf extract is between 0.01 and 0.5 wt% and the content of centella asiatica extract is between 0.01 and 0.3 wt%.
9. The use of claim 7, wherein the oral product comprises a restorative toothpaste, a mouthwash, a mouth repair gel, a mouth spray, a mouth freshener, or an exploding bead.
10. The hyaluronic acid essential oil nourishing and repairing toothpaste is characterized by comprising the following components in percentage by weight:
and the balance purified water.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202111416101.3A CN114159500A (en) | 2021-11-25 | 2021-11-25 | Hyaluronic acid essential oil composition for nourishing and repairing oral cavity and application thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202111416101.3A CN114159500A (en) | 2021-11-25 | 2021-11-25 | Hyaluronic acid essential oil composition for nourishing and repairing oral cavity and application thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN114159500A true CN114159500A (en) | 2022-03-11 |
Family
ID=80480821
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202111416101.3A Pending CN114159500A (en) | 2021-11-25 | 2021-11-25 | Hyaluronic acid essential oil composition for nourishing and repairing oral cavity and application thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN114159500A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114983872A (en) * | 2022-05-30 | 2022-09-02 | 浙江大学 | Swallowable bead-blasting mouth wash with excellent blood compatibility and preparation method thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20190076497A1 (en) * | 2017-09-11 | 2019-03-14 | Kenneth Davin Fine | Oral and intestinal health products |
| CN110585062A (en) * | 2019-09-30 | 2019-12-20 | 华熙生物科技股份有限公司 | Hyaluronic acid oral care composition and preparation method and application thereof |
| CN111557877A (en) * | 2020-06-24 | 2020-08-21 | 三椒口腔健康股份有限公司 | Toothpaste containing centella extract and preparation method thereof |
-
2021
- 2021-11-25 CN CN202111416101.3A patent/CN114159500A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20190076497A1 (en) * | 2017-09-11 | 2019-03-14 | Kenneth Davin Fine | Oral and intestinal health products |
| CN110585062A (en) * | 2019-09-30 | 2019-12-20 | 华熙生物科技股份有限公司 | Hyaluronic acid oral care composition and preparation method and application thereof |
| CN111557877A (en) * | 2020-06-24 | 2020-08-21 | 三椒口腔健康股份有限公司 | Toothpaste containing centella extract and preparation method thereof |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114983872A (en) * | 2022-05-30 | 2022-09-02 | 浙江大学 | Swallowable bead-blasting mouth wash with excellent blood compatibility and preparation method thereof |
| CN114983872B (en) * | 2022-05-30 | 2023-11-28 | 浙江大学 | Swallowing bead-bursting mouthwash with excellent blood compatibility and preparation method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN107281013B (en) | Toothpaste for removing tooth stain and inhibiting dental plaque | |
| US20090269288A1 (en) | Black pearl toothpaste | |
| CN107468553B (en) | Dental caries prevention toothpaste | |
| CN107595750B (en) | Active anti-inflammation toothpaste | |
| EP2155222A2 (en) | Extract of trigonella foenum-graecum | |
| CN107184476A (en) | A kind of antibacterial mouthwash and preparation method thereof | |
| CN107811890A (en) | A kind of oral cavity caring toothpaste composition | |
| JP7463429B2 (en) | Oral Composition | |
| CN110946778A (en) | Toothpaste with anti-inflammation and bacteriostasis functions | |
| CN114159500A (en) | Hyaluronic acid essential oil composition for nourishing and repairing oral cavity and application thereof | |
| CN112426376B (en) | Mouthwash and preparation method thereof | |
| CN107485584B (en) | Oral care composition | |
| CN113318057B (en) | Old people nursing toothpaste and preparation method and application thereof | |
| CN107320368B (en) | A kind of adult toothpaste and preparation method thereof grey containing Chinese mugwort | |
| CN110151915A (en) | A kind of propolis oral nursing liquid and preparation method thereof | |
| Öznurhan et al. | Antimicrobial efficacy of chlorhexidine and licorice mouthwashes in children | |
| CN108403544A (en) | A kind of Pediatric Oral Emergency care composition and preparation method thereof | |
| CN107362112B (en) | Gum-protecting and healing toothpaste | |
| KR100519477B1 (en) | Periodontal disease prevention and treatment composition containing trichromic acid, urodessoxycholine acid derivative and milky skin extract | |
| KR101660467B1 (en) | Oral composition containing fermentative extract of lycii fructus as active ingredient | |
| CN112137928A (en) | Multi-effect toothpaste and preparation method thereof | |
| KR101910716B1 (en) | Mouthwash containing green tea | |
| CN106714791A (en) | Inhibition of maturation of dental biofilm and cariogenic properties | |
| CN113577243B (en) | Active polypeptide-PDRN composition and application thereof in preparation of nursing products | |
| CN114404522B (en) | Chinese herbal medicine composition, gargle and preparation method |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20220311 |
|
| RJ01 | Rejection of invention patent application after publication |