CN108403544A - A kind of Pediatric Oral Emergency care composition and preparation method thereof - Google Patents
A kind of Pediatric Oral Emergency care composition and preparation method thereof Download PDFInfo
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- A61K8/00—Cosmetics or similar toiletry preparations
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- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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Abstract
The invention discloses a kind of Pediatric Oral Emergency care compositions and preparation method thereof.The Pediatric Oral Emergency care composition, by weight percentage, including the following raw material：Moisturizer 2~10%, foaming agent 1~5%, sweetener 0.05~2%, metal salt 0.1~7%, keratolytic 0.01~5%, sodium phytate 1~5%, licorice 1~5%, peace east Folium Aloe extract 0.5~2%, ring conopsea extraction 1~3%, Faeces Passeris extract 3~8%, mint extract 0.5~2%, multi-vitamins 0.5~4%, yeast polypeptides 0.3~2%, cationic surfactant 3~8%, preservative 0.5~3%, poloxamer 2~7%, essence 1~2%, water surplus.The effect of Pediatric Oral Emergency care composition provided by the present invention includes plant extracts and sterilization shield gum ingredient, mouthfeel is naturally pure, have the function of significant sterilization, fall fire anti-inflammatory, pain easing and hemostasis, is suitble to common oral care, can effectively clear up oral cavity and firm tooth；It is notable to the therapeutic effect of canker sore, bleeding gums, periodontosis, saprodontia；The preparation method of the present invention is easy, is suitable for large-scale production, high financial profit.
Description
Technical field
The present invention relates to oral care techniques field, more particularly to a kind of Pediatric Oral Emergency care composition and its preparation side
Method.
Background technology
Common mouth disease includes canker sore, periodontosis, saprodontia.Clinically, canker sore is commonly called as " aphtha ", is one
The common ulcerative damages illness for betiding mucous membrane of mouth of kind, is divided into Catarrhal, aphthous, blister, phlegmonous, puppet
Film property, exedens and types, the incidence such as papular are up to 70%~90%.Its common clinical symptoms all show as salivation,
Loss of appetite or feeding slowly, oral malodor, mucous membrane of mouth flush, heat, swelling, pain.Periodontosis refer mainly to gingivitis and
Periodontitis；Gingivitis refers to acute, the chronic inflammation for being happened at gingiva tissue, and common manifestation is bleeding gums, redness, distending pain,
The recurrent exerbation of canker sore is also resulted in, the two can also interact, and form vicious circle, if without effectively treating,
It is possible that lead to periodontitis to Deep Development, the problem for causing tooth mobility, loss of tooth etc. more serious.Periodontitis is to invade tooth
The chronic inflammation of gum and periodontium is a kind of destructive disease, mostly because bacterial plaque, dental calculus, caulked in kind, ill fitting prosthesis,
It stings wound etc. and causes various focusing depths represented swelling, while being that bacterial plaque accumulation aggravates, and is prolonged by expanding under gingivally on gum.Due to Tiny ecosystem under gum
The characteristics of environment, grows the larger Periodontal Pathogens of this large amount of virulence in subgingival plaque, as gum bacteroid, intermediate bacteroid,
Conveyor screw etc., makes the increased inflammation of gum and expansion is prolonged, and leads to the absorption of alveolar bone of periodontal bag formation, causes periodontitis, so tooth
Caused by the main inducing of Zhou Yan is also due to the accumulation of plaque.
Currently, canker sore can be used to treat and the Chinese herbal medicine of periodontosis to be more, Chinese Traditional Medicine is raw materials used to be mostly
Plant or mineralogical composition.Wherein, plant is generally the extracts such as its root, stem and leaf, by practice and screening in 1,100, is included in《In
State's pharmacopeia》Medicinal herb components with its unique medical value and safety be the rarity of the Chinese nation.With scientific and technological level
Continuous improvement, have nearly 3800 kinds of raw materials can use its clear active constituent of analysis method, be carried out at the same time qualitative or quantitative inspection
It surveys.The effect of active constituent, is also constantly confirming.The oral-cavity articles such as exploitation and development Chinese herbal toothpaste treatment canker sore and tooth
All diseases also become the new issue of research in recent years.It is no lack of Chinese herbal toothpaste or other oral-cavity articles in commercial product, but is treating
The effect is unsatisfactory in terms of canker sore, gingivitis, and most of existing oral-cavity article is just for oral cleaning and transience
Fresh breath, can't there is the improvement on essential meaning, some even can damage enamel, facing to oral care so that
Tooth is fragile, while can also stimulate and further damage mucous membrane of mouth, is unfavorable for oral health, and be not particularly well suited for children.
Invention content
The technical problem to be solved in the present invention is to provide a kind of Pediatric Oral Emergency care compositions and preparation method thereof.The present invention
Pediatric Oral Emergency care composition mouthfeel it is naturally pure, have the function of significant sterilization, fall fire anti-inflammatory, pain easing and hemostasis, it is suitable
Common oral care is closed, can effectively clear up oral cavity, firm tooth, and have to canker sore, bleeding gums, periodontosis, saprodontia
Significant therapeutic effect；The preparation method of the present invention is easy, easily operated, is suitable for large-scale production, high financial profit.
In order to solve the above-mentioned technical problem, the technical scheme is that：
In a first aspect, a kind of Pediatric Oral Emergency care composition provided by the invention, by weight percentage, including it is following former
Material：Moisturizer 2~10%, foaming agent 1~5%, sweetener 0.05~2%, metal salt 0.1~7%, keratolytic 0.01~
5%, sodium phytate 1~5%, licorice 1~5%, the eastern Folium Aloe extract 0.5~2% of peace, ring conopsea extraction 1~
3%, Faeces Passeris extract 3~8%, mint extract 0.5~2%, multi-vitamins 0.5~4%, yeast polypeptides 0.3~
2%, cationic surfactant 3~8%, preservative 0.5~3%, poloxamer 2~7%, essence 1~2%, water surplus.It is excellent
Choosing, the licorice, peace east Folium Aloe extract, ring conopsea extraction, Faeces Passeris extract, mint extract are powder
Shape, medicinal extract or extracting solution.
Preferably, the moisturizer is one or more in propylene glycol, sorbierite, glycerine.
Preferably, the foaming agent is in lauroyl glutamate disodium, sodium lauroyl sarcosine, lauryl sodium sulfate
It is one or more.
Preferably, the sweetener be selected from xylitol, glycyrrhizin, Aspartame, neotame, sodium cyclohexylsulfamate,
It is one or more in L-aspartyl-L-phenylalanine methylester alitame, Sucralose.
Preferably, the metal salt is one or more in zinc salt, mantoquita, tin salt, sylvite.
Preferably, the keratolytic is allantoin.
Preferably, the multi-vitamins be selected from VitAVitE, vitamin C, biotin, folic acid, cyanocobalamin,
Vitamin B3, pantothenic acid, vitamin B6, vitamin B2, vitamin B1In it is one or more.
Preferably, the cationic surfactant is one or more in Cetylpyridinium Chloride, Chlorhexidine, Domiphen bromide.
Preferably, the preservative is one or more in sodium benzoate, parabens, potassium sorbate.
Second aspect, the method provided by the invention for preparing Pediatric Oral Emergency care composition as described in relation to the first aspect, including
Following steps：
(1) by sweetener, metal salt, keratolytic, sodium phytate, licorice, the eastern Folium Aloe extract of peace, ring
After conopsea extraction, Faeces Passeris extract, mint extract, multi-vitamins, yeast polypeptides, cationic surfactant mixing,
Water is added, mixture A is obtained after being uniformly mixed；
(2) after mixing poloxamer, essence, moisturizer is added, is stirred to obtain mixture B；
(3) mixture A is added in the mixture B obtained by step (2), is stirred to obtain mixture C；
(4) foaming agent is added in the mixture C obtained by step (3), is stirred to obtain mixture D；
(5) preservative is added in the mixture D obtained by step (4), is stirred to obtain Pediatric Oral Emergency nursing combination
Object.
Compared with prior art, the beneficial effects of the present invention are：
The effect of Pediatric Oral Emergency care composition provided by the present invention includes plant extracts and sterilization shield gum ingredient, mouth
Sense is natural pure, has the function of significant sterilization, fall fire anti-inflammatory, pain easing and hemostasis, is suitble to common oral care, can effectively clear up
Oral cavity and firm tooth；All kinds of raw materials of the present invention, which reach, to be complementary to one another, cooperates with each other, and prevention and treatment oral cavity is played
Ulcer, periodontitis, sensitivity of tooth, the bleeding of gum redness, the effect of saprodontia；The preparation method of the present invention is easy, easily operated, fits
In large-scale production, high financial profit.
Specific implementation mode
The specific implementation mode of the present invention is described further below.It should be noted that for these implementations
The explanation of mode is used to help understand the present invention, but does not constitute limitation of the invention.In addition, invention described below
Involved technical characteristic can be combined with each other as long as they do not conflict with each other in each embodiment.
In a first aspect, a kind of Pediatric Oral Emergency care composition provided by the invention, by weight percentage, including it is following former
Material：Moisturizer 2~10%, foaming agent 1~5%, sweetener 0.05~2%, metal salt 0.1~7%, keratolytic 0.01~
5%, sodium phytate 1~5%, licorice 1~5%, the eastern Folium Aloe extract 0.5~2% of peace, ring conopsea extraction 1~
3%, Faeces Passeris extract 3~8%, mint extract 0.5~2%, multi-vitamins 0.5~4%, yeast polypeptides 0.3~
2%, cationic surfactant 3~8%, preservative 0.5~3%, poloxamer 2~7%, essence 1~2%, water surplus.
In an embodiment of the present invention, weight percent of the moisturizer in the Pediatric Oral Emergency care composition is 3.5
~7%.
In an embodiment of the present invention, the moisturizer is one or more in propylene glycol, sorbierite, glycerine.
Further, in this embodiment, the moisturizer includes propylene glycol, sorbierite, wherein the propylene glycol exists
Weight percent in the Pediatric Oral Emergency care composition is 3~5%, and the sorbierite is nursed in the Pediatric Oral Emergency and combined
Weight percent in object is 0.5~2%.
In an embodiment of the present invention, the foaming agent is selected from lauroyl glutamate disodium, sodium lauroyl sarcosine, ten
It is one or more in sodium dialkyl sulfate.
Further, in this embodiment, the foaming agent is lauroyl glutamate disodium.
In the present invention, the lauroyl glutamate disodium can be stopped dental caries with antibacterial, improve calcium, phosphorus content, energy in enamel
Enough change the acid-base property of enamel surface, enhance its capacity antacid, and it can also effectively extend the guarantor of oral cavity nursing agent
The matter phase prevents the generation for having precipitation in oral cavity nursing agent.
In an embodiment of the present invention, the sweetener is selected from xylitol, glycyrrhizin, Aspartame, neotame, hexamethylene
It is one or more in base sulfamic acid sodium, L-aspartyl-L-phenylalanine methylester alitame, Sucralose.
Further, in this embodiment, the sweetener includes xylitol and glycyrrhizin, wherein the xylose
Weight percent of the alcohol in the Pediatric Oral Emergency care composition is 0.05~0.5%, and the glycyrrhizin is in the children
Weight percent in oral care composition is 0.1~1%.
In the present invention, the xylitol and glycyrrhizin are pure natural sweetener, have the high and low thermal energy of sugariness,
Safe and non-toxic and stronger medicinal health care function can also avoid the sweeteners such as Sucralose from inducing the diseases such as hypertension, diabetes
The drawback of disease, while having the effects that anti-inflammatory, antiallergy and protection membrane structure.
In an embodiment of the present invention, weight percent of the metal salt in the Pediatric Oral Emergency care composition
It is 1.5~4%.
In an embodiment of the present invention, the one kind or more of the metal salt in zinc salt, mantoquita, tin salt, sylvite
Kind.
Further, in this embodiment, the metal salt includes mantoquita, zinc salt, wherein the mantoquita is in the youngster
Weight percent in virgin oral care composition is 1~2%；Weight of the zinc salt in the Pediatric Oral Emergency care composition
It is 0.5~2% to measure percentage.
Further, in this embodiment, the mantoquita is selected from copper chlorophyll, copper fluoride, copper chloride, cupric iodide, chlorine
It is one or more in copper fluoride, copper acetate, hexafluoro zirconium acid copper, copper sulphate, copper lactate, copper citrate.
Further, in this embodiment, the mantoquita is copper chlorophyll.
Further, in this embodiment, the zinc salt is selected from glycine zine, zinc fluoride, zinc chloride, zinc iodide, chlorine
Zinc fluoride, zinc acetate, hexafluoro zirconium acid zinc, zinc sulfate, zinc lactate, zinc tartrate, zinc gluconate, zinc citrate, zinc malate
In it is one or more.
Further, in this embodiment, the zinc salt is glycine zine.
In an embodiment of the present invention, the keratolytic is allantoin.
Further, in this embodiment, weight hundred of the allantoin in the Pediatric Oral Emergency care composition
Divide than being 0.1~2%.
In the present invention, the allantoin is used for mouth skin surface, and skin keratin is made to soften, and promotes organization healing, can
Enhance the bactericidal effect of antiseptic, while there is certain itching-relieving action.
In the present invention, a kind of important fully natural green additive of the sodium phytate, most significant feature are and metal
Ion has extremely strong chelating effect, stronger inoxidizability and color protection；And on facing color spot or be deposited on facing
Alkaline bacterial plaque play good complexing agent dissolution, tooth stain is removed in help makes conditioning liquid during use, although not having
The mechanical friction for playing the role of toothbrush can also reach certain cleaning plaque.
It is the licorice, peace east Folium Aloe extract, ring conopsea extraction, white in an embodiment of the present invention
Flos Caryophylli extract, mint extract are powdery, medicinal extract or extracting solution.
It is the eastern Folium Aloe extract of licorice that the present invention uses, peace, ring conopsea extraction, Faeces Passeris extract, thin
Lotus extract is traditional Chinese medicine ingredients safe efficient, pure natural, without incompatibility；The present invention creatively carries these four Chinese medicines
It takes object to combine, acts synergistically, wherein the licorice contains glycyrrhizin, enoxolone, a variety of flavonoids
Object is closed, has the function of clearing heat and detoxicating, relieving spasm to stop pain, coordinating the drug actions of a prescription；The main component of the ring conopsea extraction is saponin(e, also
Containing ingredients such as abundant amino acid, polysaccharide, a small amount of volatile oil, panax japonicus saponin can activate the protective factors of mucous membrane of mouth,
Mucous membrane of mouth oxygen radical, lipid peroxide are removed, has the function of swelling and pain relieving, antiulcer；The Faeces Passeris extract
Rich in volatile oil, main component is eugenol, carypohyllene, has effects that anti-inflammatory, sterilization, analgesia；The eastern Chinese aloe leaf of the peace carries
Take object that there is anti-inflammation and sterilization, clearing heat for detumescence, softening skin, guarantor rich in Aloin A, wound hormone and glycan peptide sweet dew (Ke-2) etc.
The function of cell viability is held, curdlan is combined also with traumatic acid has healing wounds activity；The mint extract contains thin
Lotus alcohol, menthones, menthyl acetate etc. have the effects that Xiaofeng San heat, pharynx-clearing throat-benefiting, anti-inflammatory analgetic, sterilizing and itch-relieving.
In an embodiment of the present invention, the multi-vitamins are selected from VitAVitE, vitamin C, vitamin
H, folic acid, cyanocobalamin, vitamin B3, pantothenic acid, vitamin B6, vitamin B2, vitamin B1In it is one or more.
In the present invention, the multi-vitamins have the synthesis for promoting collagen, prevent the effect of bleeding gums.
In the present invention, the yeast polypeptides easily disperse, are dissolved in the water, and thermal stability is strong, and Pediatric Oral Emergency both can be changed
Care composition and quality, flavor, can also enhance functionality；Organic peptide is mainly with micromolecule active polypeptide in the yeast polypeptides
Form exist, avoid the anaphylaxis of macro-molecular protein, containing amino acid in needed by human 8, amino acid classes are complete；
Also contain folic acid, vitamin B3, pantothenic acid, vitamin B6, vitamin B2, vitamin B1, minerals, the physiological activity object such as nucleotide
Matter, and fat content is then well below 1%.
In an embodiment of the present invention, the cationic surfactant is in Cetylpyridinium Chloride, Chlorhexidine, Domiphen bromide
It is one or more.
Further, in this embodiment, the cationic surfactant includes Cetylpyridinium Chloride, Chlorhexidine, degree rice
It is fragrant, wherein weight percent of the Cetylpyridinium Chloride in the Pediatric Oral Emergency care composition is 1~2%, the Chlorhexidine
Weight percent in the Pediatric Oral Emergency care composition is 0.5~1.5%, and the Domiphen bromide is protected in the Pediatric Oral Emergency
It is 1.5~4.5% to manage the weight percent in composition.
In the present invention, the effect of the Cetylpyridinium Chloride is sterilization, mainly for anaerobic bacteria.
In the present invention, the Chlorhexidine also known as chlorohexidene, the entitled chlorhexidine of chemistry have great wide
Antibacterial, bactericidal effect is composed, is a kind of preferable sterilizing medicine；Its band positive electricity, oral cavity are negatively charged containing being adsorbed on when gargling
Patch and oral mucosal surface, the drug then adsorbed are gradually precipitated from these position disperses and generate lasting effect, until 24
Concentration reduces in saliva after hour, and this product is adsorbed on the permeability barrier of bacterial cytoplasm film, cellular content is made to leak out, low concentration
When be in bacteriostasis, be in bactericidal effect when high concentration.Even if still valid in the presence ofs having serum, blood etc.；But to gemma, anti-
Acidfast bacilli, fungi and virus are invalid.
In the present invention, the Domiphen bromide also known as domiphen, Dumet is fragrant, domiphen, Anaprox；White or yellowish knot
Crystalline substance, odorless or micro-strip special smell, mildly bitter flavor and with scent, there is broad-spectrum bactericidal action, acting in alkalinity enhances.
In an embodiment of the present invention, the preservative in sodium benzoate, parabens, potassium sorbate one
Kind is a variety of.
Further, in this embodiment, the preservative is potassium sorbate.
In an embodiment of the present invention, the poloxamer is selected from PLURONICS F87, poloxamer 237, poloxamer
401 and poloxamer188.
The poloxamer of the present invention is two connect by the central hydrophobic chain and side of polyoxypropylene (poly- (propylene oxide))
The nonionic triblock copolymer of the hydrophilic chain composition of polyoxyethylene (poly- (ethylene oxide)).
Further, in this embodiment, the poloxamer is poloxamer188 (by BASF conducts
PluronicTM F127 are supplied by Croda as SynperonicTM PE/F 127), poloxamer188 has than other
The water solubility that poloxamer improves and the emulsibility improved.
Second aspect, the method provided by the invention for preparing Pediatric Oral Emergency care composition as described in relation to the first aspect, including
Following steps：
(1) by sweetener, metal salt, keratolytic, sodium phytate, licorice, the eastern Folium Aloe extract of peace, ring
After conopsea extraction, Faeces Passeris extract, mint extract, multi-vitamins, yeast polypeptides, cationic surfactant mixing,
Water is added, mixture A is obtained after being uniformly mixed；
(2) after mixing poloxamer, essence, moisturizer is added, is stirred to obtain mixture B；
(3) mixture A is added in the mixture B obtained by step (2), is stirred to obtain mixture C；
(4) foaming agent is added in the mixture C obtained by step (3), is stirred to obtain mixture D；
(5) preservative is added in the mixture D obtained by step (4), is stirred to obtain Pediatric Oral Emergency nursing combination
Object.
In following embodiment and comparative example, the eastern Folium Aloe extract of licorice, peace, ring conopsea extraction, white lilac
Extract, mint extract are medicinal extract.
Embodiment 1
A kind of preparation method of Pediatric Oral Emergency care composition provided in an embodiment of the present invention, includes the following steps：
(1) following raw materials by weight percentage are taken：Propylene glycol 3%, sorbierite 0.5%, lauroyl glutamate disodium
1%, xylitol 0.5%, glycyrrhizin 1%, copper chlorophyll 2%, glycine zine 0.5%, allantoin 5%, sodium phytate 5%, sweet
The eastern Folium Aloe extract 0.5% of careless extract 1%, peace, ring conopsea extraction 1%, Faeces Passeris extract 3%, mint extract
0.5%, multi-vitamins 0.9% (vitamin C, biotin, folic acid, cyanocobalamin, vitamin B3, pantothenic acid, vitamin B6, dimension life
Plain B2, vitamin B1Dosage be 0.1%), yeast polypeptides 0.3%, Domiphen bromide 1.5%, chlorhexidine 1.5%, Cetylpyridinium Chloride
2%, lauroyl glutamate disodium 3%, poloxamer188 7%, essence 2%, water surplus；
(2) by xylitol, glycyrrhizin, copper chlorophyll, glycine zine, allantoin, sodium phytate, licorice, An Dong
Folium Aloe extract, ring conopsea extraction, Faeces Passeris extract, mint extract, multi-vitamins, yeast polypeptides, Domiphen bromide,
After chlorhexidine, Cetylpyridinium Chloride mixing, 45 DEG C of distilled water is added, mixture A is obtained after being uniformly mixed；
(3) after mixing poloxamer188 407, essence, propylene glycol, sorbierite are stirred to obtain mixture B；
(4) mixture A is added in mixture B, is stirred to obtain mixture C；
(5) lauroyl glutamate disodium is added in mixture C, is stirred to obtain mixture D；
(6) potassium sorbate is added in mixture D, is stirred to obtain Pediatric Oral Emergency care composition.
Embodiment 2
A kind of preparation method of Pediatric Oral Emergency care composition provided in an embodiment of the present invention, includes the following steps：
(1) following raw materials by weight percentage are taken：Propylene glycol 5%, sorbierite 2%, lauroyl glutamate disodium
5%, xylitol 0.05%, glycyrrhizin 1%, copper chlorophyll 1%, glycine zine 2%, allantoin 0.01%, sodium phytate 1%,
The eastern Folium Aloe extract 2% of licorice 5%, peace, ring conopsea extraction 3%, Faeces Passeris extract 8%, mint extract
2%, multi-vitamins 3.6% (vitamin C, biotin, folic acid, cyanocobalamin, vitamin B3, pantothenic acid, vitamin B6, vitamin
B2, vitamin B1Dosage be 0.4%), yeast polypeptides 2%, Domiphen bromide 4%, chlorhexidine 0.5%, Cetylpyridinium Chloride 1%, bay
Acyl disodium glutamate 0.5%, poloxamer188 2%, essence 1%, water surplus；
(2) by xylitol, glycyrrhizin, copper chlorophyll, glycine zine, allantoin, sodium phytate, licorice, An Dong
Folium Aloe extract, ring conopsea extraction, Faeces Passeris extract, mint extract, multi-vitamins, yeast polypeptides, Domiphen bromide,
After chlorhexidine, Cetylpyridinium Chloride mixing, 45 DEG C of distilled water is added, mixture A is obtained after being uniformly mixed；
(3) after mixing poloxamer188 407, essence, propylene glycol, sorbierite are stirred to obtain mixture B；
(4) mixture A is added in mixture B, is stirred to obtain mixture C；
(5) lauroyl glutamate disodium is added in mixture C, is stirred to obtain mixture D；
(6) potassium sorbate is added in mixture D, is stirred to obtain Pediatric Oral Emergency care composition.
Embodiment 3
A kind of preparation method of Pediatric Oral Emergency care composition provided in an embodiment of the present invention, includes the following steps：
(1) following raw materials by weight percentage are taken：Propylene glycol 4%, sorbierite 1%, lauroyl glutamate disodium
3%, xylitol 0.2%, glycyrrhizin 0.8%, copper chlorophyll 1.4%, glycine zine 1.6%, allantoin 2%, sodium phytate
3%, the eastern Folium Aloe extract 1% of licorice 2%, peace, ring conopsea extraction 2%, Faeces Passeris extract 4%, peppermint carry
Take object 1.5%, multi-vitamins 1.8% (vitamin C, biotin, folic acid, cyanocobalamin, vitamin B3, pantothenic acid, vitamin B6、
Vitamin B2, vitamin B1Dosage be 0.2%), yeast polypeptides 1%, Domiphen bromide 2%, chlorhexidine 1%, Cetylpyridinium Chloride
1.4%, lauroyl glutamate disodium 2%, poloxamer188 4%, essence 1.5%, water surplus；
(2) by xylitol, glycyrrhizin, copper chlorophyll, glycine zine, allantoin, sodium phytate, licorice, An Dong
Folium Aloe extract, ring conopsea extraction, Faeces Passeris extract, mint extract, multi-vitamins, yeast polypeptides, Domiphen bromide,
After chlorhexidine, Cetylpyridinium Chloride mixing, 45 DEG C of distilled water is added, mixture A is obtained after being uniformly mixed；
(3) after mixing poloxamer188 407, essence, propylene glycol, sorbierite are stirred to obtain mixture B；
(4) mixture A is added in mixture B, is stirred to obtain mixture C；
(5) lauroyl glutamate disodium is added in mixture C, is stirred to obtain mixture D；
(6) potassium sorbate is added in mixture D, is stirred to obtain Pediatric Oral Emergency care composition.
Embodiment 4
A kind of preparation method of Pediatric Oral Emergency care composition provided in an embodiment of the present invention, includes the following steps：
(1) following raw materials by weight percentage are taken：Propylene glycol 3.5%, sorbierite 1.5%, lauroyl glutamate two
Sodium 2.5%, xylitol 0.4%, glycyrrhizin 0.3%, copper chlorophyll 1.6%, glycine zine 1%, allantoin 2%, sodium phytate
3%, the eastern Folium Aloe extract 1.5% of licorice 3%, peace, ring conopsea extraction 2%, Faeces Passeris extract 4%, peppermint
Extract 1%, multi-vitamins 1.8% (vitamin C, biotin, folic acid, cyanocobalamin, vitamin B3, pantothenic acid, vitamin B6、
Vitamin B2, vitamin B1Dosage be 0.2%), yeast polypeptides 0.8%, Domiphen bromide 3%, chlorhexidine 0.8%, Cetylpyridinium Chloride
1.6%, lauroyl glutamate disodium 2%, poloxamer188 3%, essence 1.2%, water surplus；
(2) by xylitol, glycyrrhizin, copper chlorophyll, glycine zine, allantoin, sodium phytate, licorice, An Dong
Folium Aloe extract, ring conopsea extraction, Faeces Passeris extract, mint extract, multi-vitamins, yeast polypeptides, Domiphen bromide,
After chlorhexidine, Cetylpyridinium Chloride mixing, 45 DEG C of distilled water is added, mixture A is obtained after being uniformly mixed；
(3) after mixing poloxamer188 407, essence, propylene glycol, sorbierite are stirred to obtain mixture B；
(4) mixture A is added in mixture B, is stirred to obtain mixture C；
(5) lauroyl glutamate disodium is added in mixture C, is stirred to obtain mixture D；
(6) potassium sorbate is added in mixture D, is stirred to obtain Pediatric Oral Emergency care composition.
Embodiment 5
A kind of preparation method of Pediatric Oral Emergency care composition provided in an embodiment of the present invention, includes the following steps：
(1) following raw materials by weight percentage are taken：Propylene glycol 4%, sorbierite 1.5%, lauroyl glutamate disodium
4%, xylitol 0.4%, glycyrrhizin 0.5%, copper chlorophyll 1.5%, glycine zine 1.2%, allantoin 4%, sodium phytate
2%, licorice 2%, the eastern Folium Aloe extract 1.5% of peace, ring conopsea extraction 2.5%, Faeces Passeris extract 6%, thin
Lotus extract 1.5%, multi-vitamins 2.7% (vitamin C, biotin, folic acid, cyanocobalamin, vitamin B3, pantothenic acid, dimension life
Plain B6, vitamin B2, vitamin B1Dosage be 0.3%), yeast polypeptides 1.8%, Domiphen bromide 2.5%, chlorhexidine 1.2%,
Cetylpyridinium Chloride 1.8%, lauroyl glutamate disodium 2%, poloxamer188 3%, essence 1%, water surplus；
(2) by xylitol, glycyrrhizin, copper chlorophyll, glycine zine, allantoin, sodium phytate, licorice, An Dong
Folium Aloe extract, ring conopsea extraction, Faeces Passeris extract, mint extract, multi-vitamins, yeast polypeptides, Domiphen bromide,
After chlorhexidine, Cetylpyridinium Chloride mixing, 45 DEG C of distilled water is added, mixture A is obtained after being uniformly mixed；
(3) after mixing poloxamer188 407, essence, propylene glycol, sorbierite are stirred to obtain mixture B；
(4) mixture A is added in mixture B, is stirred to obtain mixture C；
(5) lauroyl glutamate disodium is added in mixture C, is stirred to obtain mixture D；
(6) potassium sorbate is added in mixture D, is stirred to obtain Pediatric Oral Emergency care composition.
Embodiment 6
A kind of preparation method of Pediatric Oral Emergency care composition provided in an embodiment of the present invention, includes the following steps：
(1) following raw materials by weight percentage are taken：Propylene glycol 4.5%, sorbierite 1%, lauroyl glutamate disodium
3%, xylitol 0.3%, glycyrrhizin 0.5%, copper chlorophyll 1.5%, glycine zine 1.5%, allantoin 4%, sodium phytate
2%, licorice 3%, the eastern Folium Aloe extract 1.5% of peace, ring conopsea extraction 1.5%, Faeces Passeris extract 4.5%,
Mint extract 0.75%, multi-vitamins 1.8% (vitamin C, biotin, folic acid, cyanocobalamin, vitamin B3, pantothenic acid, dimension
Raw element B6, vitamin B2, vitamin B1Dosage be 0.2%), yeast polypeptides 1.2%, Domiphen bromide 2.4%, chlorhexidine
0.8%, Cetylpyridinium Chloride 1.2%, lauroyl glutamate disodium 0.8%, poloxamer188 3%, essence 1.2%, water surplus；
(2) by xylitol, glycyrrhizin, copper chlorophyll, glycine zine, allantoin, sodium phytate, licorice, An Dong
Folium Aloe extract, ring conopsea extraction, Faeces Passeris extract, mint extract, multi-vitamins, yeast polypeptides, Domiphen bromide,
After chlorhexidine, Cetylpyridinium Chloride mixing, 45 DEG C of distilled water is added, mixture A is obtained after being uniformly mixed；
(3) after mixing poloxamer188, essence, propylene glycol, sorbierite are stirred to obtain mixture B；
(4) mixture A is added in mixture B, is stirred to obtain mixture C；
(5) lauroyl glutamate disodium is added in mixture C, is stirred to obtain mixture D；
(6) potassium sorbate is added in mixture D, is stirred to obtain Pediatric Oral Emergency care composition.
Comparative example 1
A kind of preparation method for Pediatric Oral Emergency care composition that comparative example of the present invention provides, includes the following steps：
(1) following raw materials by weight percentage are taken：Propylene glycol 4.5%, sorbierite 1%, lauroyl glutamate disodium
3%, xylitol 0.3%, glycyrrhizin 0.5%, copper chlorophyll 1.5%, glycine zine 1.5%, allantoin 4%, sodium phytate
2%, licorice 3%, the eastern Folium Aloe extract 1.5% of peace, ring conopsea extraction 1.5%, mint extract 0.75%, multiple
Close vitamin 1.8% (vitamin C, biotin, folic acid, cyanocobalamin, vitamin B3, pantothenic acid, vitamin B6, vitamin B2, dimension life
Plain B1Dosage be 0.2%), yeast polypeptides 1.2%, Domiphen bromide 2.4%, chlorhexidine 0.8%, Cetylpyridinium Chloride 1.2%, sorb
Sour potassium 0.8%, poloxamer188 3%, essence 1.2%, water surplus；
(2) by xylitol, glycyrrhizin, copper chlorophyll, glycine zine, allantoin, sodium phytate, licorice, An Dong
Folium Aloe extract, ring conopsea extraction, mint extract, multi-vitamins, yeast polypeptides, Domiphen bromide, chlorhexidine, western pyrrole chlorine
After ammonium mixing, 45 DEG C of distilled water is added, mixture A is obtained after being uniformly mixed；
(3) after mixing poloxamer188, essence, propylene glycol, sorbierite are stirred to obtain mixture B；
(4) mixture A is added in mixture B, is stirred to obtain mixture C；
(5) lauroyl glutamate disodium is added in mixture C, is stirred to obtain mixture D；
(6) potassium sorbate is added in mixture D, is stirred to obtain Pediatric Oral Emergency care composition.
Comparative example 2
A kind of preparation method for Pediatric Oral Emergency care composition that comparative example of the present invention provides, includes the following steps：
(1) following raw materials by weight percentage are taken：Propylene glycol 4.5%, sorbierite 1%, lauroyl glutamate disodium
3%, xylitol 0.3%, glycyrrhizin 0.5%, copper chlorophyll 1.5%, glycine zine 1.5%, allantoin 4%, sodium phytate
2%, licorice 3%, Faeces Passeris extract 4.5%, mint extract 0.75%, multi-vitamins 1.8% (vitamin C,
Biotin, folic acid, cyanocobalamin, vitamin B3, pantothenic acid, vitamin B6, vitamin B2, vitamin B1Dosage be 0.2%),
Yeast polypeptides 1.2%, Domiphen bromide 2.4%, chlorhexidine 0.8%, Cetylpyridinium Chloride 1.2%, lauroyl glutamate disodium 0.8%, pool
Luo Shamu 4073%, essence 1.2%, water surplus；
(2) by xylitol, glycyrrhizin, copper chlorophyll, glycine zine, allantoin, sodium phytate, licorice, illiterate person
After fragrant extract, mint extract, multi-vitamins, yeast polypeptides, Domiphen bromide, chlorhexidine, Cetylpyridinium Chloride mixing, it is added 45 DEG C
Distilled water, mixture A is obtained after being uniformly mixed；
(3) after mixing poloxamer188, essence, propylene glycol, sorbierite are stirred to obtain mixture B；
(4) mixture A is added in mixture B, is stirred to obtain mixture C；
(5) lauroyl glutamate disodium is added in mixture C, is stirred to obtain mixture D；
(6) potassium sorbate is added in mixture D, is stirred to obtain Pediatric Oral Emergency care composition.
Comparative example 3
A kind of preparation method for Pediatric Oral Emergency care composition that comparative example of the present invention provides, includes the following steps：
(1) following raw materials by weight percentage are taken：Propylene glycol 4.5%, sorbierite 1%, lauroyl glutamate disodium
3%, xylitol 0.3%, glycyrrhizin 0.5%, copper chlorophyll 1.5%, glycine zine 1.5%, allantoin 4%, sodium phytate
2%, pacify eastern Folium Aloe extract 1.5%, Faeces Passeris extract 4.5%, mint extract 0.75%, multi-vitamins 1.8%
(vitamin C, biotin, folic acid, cyanocobalamin, vitamin B3, pantothenic acid, vitamin B6, vitamin B2, vitamin B1Dosage it is equal
For 0.2%), yeast polypeptides 1.2%, Domiphen bromide 2.4%, chlorhexidine 0.8%, Cetylpyridinium Chloride 1.2%, lauroyl glutamate disodium
0.8%, poloxamer188 3%, essence 1.2%, water surplus；
(2) by xylitol, glycyrrhizin, copper chlorophyll, glycine zine, allantoin, sodium phytate, the eastern Chinese aloe leaf extraction of peace
After object, Faeces Passeris extract, mint extract, multi-vitamins, yeast polypeptides, Domiphen bromide, chlorhexidine, Cetylpyridinium Chloride mixing,
45 DEG C of distilled water is added, mixture A is obtained after being uniformly mixed；
(3) after mixing poloxamer188, essence, propylene glycol, sorbierite are stirred to obtain mixture B；
(4) mixture A is added in mixture B, is stirred to obtain mixture C；
(5) lauroyl glutamate disodium is added in mixture C, is stirred to obtain mixture D；
(6) potassium sorbate is added in mixture D, is stirred to obtain Pediatric Oral Emergency care composition.
Comparative example 4
A kind of preparation method for Pediatric Oral Emergency care composition that comparative example of the present invention provides, includes the following steps：
(1) following raw materials by weight percentage are taken：Propylene glycol 4.5%, sorbierite 1%, lauroyl glutamate disodium
3%, xylitol 0.3%, glycyrrhizin 0.5%, copper chlorophyll 1.5%, glycine zine 1.5%, allantoin 4%, sodium phytate
2%, licorice 3%, the eastern Folium Aloe extract 1.5% of peace, ring conopsea extraction 1.5%, Faeces Passeris extract 4.5%,
Mint extract 0.75%, multi-vitamins 1.8% (vitamin C, biotin, folic acid, cyanocobalamin, vitamin B3, pantothenic acid, dimension
Raw element B6, vitamin B2, vitamin B1Dosage be 0.2%), yeast polypeptides 1.2%, lauroyl glutamate disodium 0.8%,
Poloxamer188 3%, essence 1.2%, water surplus；
(2) by xylitol, glycyrrhizin, copper chlorophyll, glycine zine, allantoin, sodium phytate, licorice, An Dong
After Folium Aloe extract, ring conopsea extraction, Faeces Passeris extract, mint extract, multi-vitamins, yeast polypeptides, mixing,
45 DEG C of distilled water is added, mixture A is obtained after being uniformly mixed；
(3) after mixing poloxamer188, essence, propylene glycol, sorbierite are stirred to obtain mixture B；
(4) mixture A is added in mixture B, is stirred to obtain mixture C；
(5) lauroyl glutamate disodium is added in mixture C, is stirred to obtain mixture D；
(6) potassium sorbate is added in mixture D, is stirred to obtain Pediatric Oral Emergency care composition.
Effect example 1
Advantageous effect in order to further illustrate the present invention, to the youngster of 1~4 gained of the embodiment of the present invention 1~6 and comparative example
Virgin oral care composition carries out clinical oral test, chooses the patient 100 with sensitivity of tooth, canker sore, wherein man
50, female 50,20~60 years old age, at no distant date all cases do not take antibiotic；Ten groups are randomly divided into, is given respectively by group
Corresponding gargle physiological saline 200ml, the Pediatric Oral Emergency nursing combination of 1~4 gained of the embodiment of the present invention 1~6 and comparative example
Object 25g；Physiological saline takes 10-15ml every time, contains gargle 2-3 minutes every time；Twice daily：It is respectively used once after brushing teeth sooner or later,
Each 1min is finished in 7 days, inquires subjective symptoms, clinical test results are referring to table 1.
The clinical oral test of the Pediatric Oral Emergency care composition of 1~4 gained of 1 embodiment of the present invention 1~6 of table and comparative example
As a result
From the results shown in Table 1, the treatment effect of the Pediatric Oral Emergency care composition of 1~6 gained of the embodiment of the present invention
Pediatric Oral Emergency care composition of the fruit significantly better than 1~4 gained of comparative example, wherein the Pediatric Oral Emergency of 6 gained of the embodiment of the present invention
The therapeutic effect of care composition is best, followed by the Pediatric Oral Emergency care composition of 5 gained of the embodiment of the present invention.Comparative example 1
Raw material used by~4 and the raw material of the embodiment of the present invention 1~6 only have the difference of only a few, but therapeutic effect but differs very
Far, this illustrates that the proportioning of each raw material of the present invention is not arranged arbitrarily, but has the effect of synergy, and each component only has
With the use of when, best results, especially traditional Chinese medicinal components (licorice, the eastern Folium Aloe extract of peace, panax japonicus extraction
Object, Faeces Passeris extract, mint extract), matching between cationic surfactant (Domiphen bromide, chlorhexidine, Cetylpyridinium Chloride)
It closes.
In addition, through stability test, each raw material is found in the weight percentage ranges of the embodiment of the present invention 4~6, children
The optimal stability of oral care composition.
Effect example 2
Advantageous effect in order to further illustrate the present invention, the present invention also choose the oral cavities such as 100 saprodontia, halitosis, ulcer
9~12 years old child patient of problem nurses combination using the Pediatric Oral Emergency of 1~4 gained of the embodiment of the present invention 1~6 and comparative example
Then object 15 days is tested tested patient 2 times a day, specific testing procedure is as follows：
It acquires 100 child patients respectively with sterile test tube and 1~4 gained of the embodiment of the present invention 1~6 and comparative example is not used
Pediatric Oral Emergency care composition saliva, and use Examples 1 to 6 and the Pediatric Oral Emergency nursing group of the gained of comparative example 1~4
Saliva of the object after 15 days is closed, by saliva sample respectively with after sterile PBS solution suitably dilution, takes 0.2mL to be coated on BHI agar flat
In plate, after 37 DEG C of Anaerobic culturel 72h, BHI agar plates is eluted with the sterile PBS solutions of 2mL, collect eluent.
Blank control group：The Pediatric Oral Emergency of 1~4 gained of the unused embodiment of the present invention 1~6 and comparative example is nursed into combination
The saliva of object obtains eluent through aforesaid operations, and 1 × 10 is diluted to again with sterile PBS solution 10-6~5 × 10-6Mol/L is obtained
Then bacteria suspension draws 37 DEG C of Anaerobic culturel 72h after the suitably dilution of 1mL bacteria suspensions, then calculates clump count.
Test group：The Pediatric Oral Emergency of 1~4 gained of the embodiment of the present invention 1~6 and comparative example will have been used to nurse combination respectively
The eluent that saliva of the object after 15 days obtains aforesaid operations, 1 × 10 is diluted to sterile PBS solution 10 again-6~5 × 10- 6Mol/L obtains bacteria suspension, then draws 37 DEG C of Anaerobic culturel 72h after the suitably dilution of 1mL bacteria suspensions, then calculates clump count.
Sterilizing rate is calculated according to the following formula：
2 each group sterilizing rate statistical result of table
| Grouping | Product | Sterilizing rate (%) |
| Test group 1 | The Pediatric Oral Emergency care composition of 1 gained of embodiment | 88.78 |
| Test group 2 | The Pediatric Oral Emergency care composition of 2 gained of embodiment | 91.14 |
| Test group 3 | The Pediatric Oral Emergency care composition of 3 gained of embodiment | 93.74 |
| Test group 4 | The Pediatric Oral Emergency care composition of 4 gained of embodiment | 96.48 |
| Test group 5 | The Pediatric Oral Emergency care composition of 5 gained of embodiment | 98.24 |
| Test group 6 | The Pediatric Oral Emergency care composition of 6 gained of embodiment | 99.81 |
| Test group 7 | The Pediatric Oral Emergency care composition of 1 gained of comparative example | 54.21 |
| Test group 8 | The Pediatric Oral Emergency care composition of 2 gained of comparative example | 61.11 |
| Test group 9 | The Pediatric Oral Emergency care composition of 3 gained of comparative example | 52.37 |
| Test group 10 | The Pediatric Oral Emergency care composition of 4 gained of comparative example | 42.32 |
After the above results show the Pediatric Oral Emergency care composition 15 days using the embodiment of the present invention 1~6, Pediatric Oral Emergency
Bacterial number in saliva is significantly suppressed, wherein the Pediatric Oral Emergency care composition of the gained of the embodiment of the present invention 6 to saliva
The inhibition of anaerobic bacteria is best in liquid, followed by the Pediatric Oral Emergency care composition of 4~5 gained of the embodiment of the present invention.Comparison
Raw material used by example 1~4 and the raw material of the embodiment of the present invention 1~6 only have the difference of only a few, but bactericidal effect but differs
Very remote, this illustrates that the proportioning of each raw material of the present invention is not arranged arbitrarily, but has the effect of synergy, and each component is only
Have with the use of when, bactericidal effect is best, especially traditional Chinese medicinal components (licorice, the eastern Folium Aloe extract of peace, panax japonicus
Extract, Faeces Passeris extract, mint extract), between cationic surfactant (Domiphen bromide, chlorhexidine, Cetylpyridinium Chloride)
Cooperation.In conclusion the Pediatric Oral Emergency care composition of the embodiment of the present invention 1~6 can effectively pre- anti-caries, prevent periodontal
Scorching, ulcer, rinses the mouth, firm tooth.
Embodiments of the present invention are explained in detail above, but the present invention is not limited to described embodiments.It is right
For those skilled in the art, in the case where not departing from the principle of the invention and spirit, these embodiments are carried out more
Kind change, modification, replacement and modification, still fall in protection scope of the present invention.
Claims (10)
1. a kind of Pediatric Oral Emergency care composition, it is characterised in that：By weight percentage, including the following raw material：Moisturizer 2~
10%, foaming agent 1~5%, sweetener 0.05~2%, metal salt 0.1~7%, keratolytic 0.01~5%, sodium phytate 1
~5%, the eastern Folium Aloe extract 0.5~2% of licorice 1~5%, peace, ring conopsea extraction 1~3%, white lilac extraction
Object 3~8%, mint extract 0.5~2%, multi-vitamins 0.5~4%, yeast polypeptides 0.3~2%, cationic surface are lived
Property agent 3~8%, preservative 0.5~3%, poloxamer 2~7%, essence 1~2%, water surplus.
2. Pediatric Oral Emergency care composition according to claim 1, it is characterised in that：The licorice, An Donglu
Luxuriant growth leaf extract, ring conopsea extraction, Faeces Passeris extract, mint extract are powdery, medicinal extract or extracting solution.
3. Pediatric Oral Emergency care composition according to claim 1, it is characterised in that：The moisturizer be selected from propylene glycol,
It is one or more in sorbierite, glycerine.
4. Pediatric Oral Emergency care composition according to claim 1, it is characterised in that：The foaming agent is selected from lauroyl paddy
It is one or more in propylhomoserin disodium, sodium lauroyl sarcosine, lauryl sodium sulfate.
5. Pediatric Oral Emergency care composition according to claim 1, it is characterised in that：The sweetener be selected from xylitol,
In glycyrrhizin, Aspartame, neotame, sodium cyclohexylsulfamate, L-aspartyl-L-phenylalanine methylester alitame, Sucralose
It is one or more.
6. Pediatric Oral Emergency care composition according to claim 1, it is characterised in that：The metal salt is selected from zinc salt, copper
It is one or more in salt, tin salt, sylvite.
7. Pediatric Oral Emergency care composition according to claim 1, it is characterised in that：The keratolytic is allantois
Element.
8. Pediatric Oral Emergency care composition according to claim 1, it is characterised in that：The multi-vitamins are selected from dimension and give birth to
Plain A, vitamin E, vitamin C, biotin, folic acid, cyanocobalamin, vitamin B3, pantothenic acid, vitamin B6, vitamin B2, vitamin
B1In it is one or more.
9. Pediatric Oral Emergency care composition according to claim 1, it is characterised in that：The cationic surfactant choosing
From one or more in Cetylpyridinium Chloride, Chlorhexidine, Domiphen bromide.
10. a kind of method preparing claim 1~9 any one of them Pediatric Oral Emergency care composition, it is characterised in that：Packet
Include following steps：
(1) sweetener, metal salt, keratolytic, sodium phytate, licorice, the eastern Folium Aloe extract of peace, panax japonicus are carried
After taking object, Faeces Passeris extract, mint extract, multi-vitamins, yeast polypeptides, cationic surfactant mixing, it is added
Water obtains mixture A after being uniformly mixed；
(2) after mixing poloxamer, essence, moisturizer is added, is stirred to obtain mixture B；
(3) mixture A is added in the mixture B obtained by step (2), is stirred to obtain mixture C；
(4) foaming agent is added in the mixture C obtained by step (3), is stirred to obtain mixture D；
(5) preservative is added in the mixture D obtained by step (4), is stirred to obtain Pediatric Oral Emergency care composition.
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