CN104800132A - Preparing method of clove compound mouthwash - Google Patents
Preparing method of clove compound mouthwash Download PDFInfo
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- CN104800132A CN104800132A CN201510249966.3A CN201510249966A CN104800132A CN 104800132 A CN104800132 A CN 104800132A CN 201510249966 A CN201510249966 A CN 201510249966A CN 104800132 A CN104800132 A CN 104800132A
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Abstract
The invention provides a preparing method of clove compound mouthwash. The method comprises the following steps that sweetening agents, sour agents and essence are stirred to a dissolution state in water; then, moisture preservation agents and edible antiseptics are added into sterile water, and the materials are stirred into a clear transparent and uniformly scattered water solution; eugenol mother liquid is prepared; tea polyphenol mother liquid is prepared; pseudo-ginseng mother liquid is prepared; sodium fluoride mother liquid is prepared; the four kinds of mother liquids are mixed, in addition, PEG-40 is added, and active ingredient mother liquid in the mouthwash is obtained; in a stirring state, the water solution is slowly added into the active ingredient mother liquid; the stirring is stopped; the still standing is carried out over the night; filtering is carried out; finished products are obtained after asepsis processing. The preparing method has the advantages of simplicity and high operability, and is applicable to industrialized production.
Description
Technical field
The present invention relates to a kind of with the preparation method of Flos Caryophylli, tea polyphenols, the Radix Notoginseng multifunctional pure natural mouthwash that is primary raw material and purposes, belong to collutory field.
Background technology
Along with improving constantly of society living standard, also changing gradually again of people's dietary habit, adds living habit bad at ordinary times, emerges many oral problem thus, as periodontitis, dental caries, halitosis, oral ulcer etc.Collutory is the novel product of Technology Times, the pharmaceutical compositions of multiple treatment oral cavity, laryngopharyngeal diseases matches and develops and can directly act on site of disease by researcher, also can remove because of mouth disease, the collutory eating the halitosis that peculiar smell foodstuff, dyssomnia, psychentonia, dyspepsia etc. cause.Traditional collutory contains more ethanol, has certain harm to oral cavity, and portioned product, for reaching ideal effect, is not stinted and added chemosynthesis reagent, to improve the effect of collutory, and this way, concerning user, there is very large potential safety hazard.Plants essential oil class collutory composition novel is at present natural, have strong, the non-specific sterilization of permeability, effect is fast, the feature that effective acting time is long, side effect is little, and oral care product field is widely used at home.In addition natural Chinese medicine composition has other some biological activitys, can strengthen body immunity, has the effect of prevention and therapy cancer.
The domestic development to this kind of collutory containing natural Chinese medicinal herb composition is little at present, and existing Patents, some composition is too single, and some lacks corresponding experiment, can not ensure the safety of collutory.
Summary of the invention
The object of the present invention is to provide a kind of preparation method of Flos Caryophylli compound recipe collutory.
A preparation method for Flos Caryophylli compound recipe collutory, comprises the following steps:
1) sweeting agent, acidic flavoring agent and essence are stirred to dissolving in water, then wetting agent and food antiseptics are joined in sterilized water, stir to clarify transparent finely dispersed aqueous solution;
The weight ratio of described sweeting agent, acidic flavoring agent, essence, wetting agent, food antiseptics is 0.01 ~ 1:0.02 ~ 1:0.5 ~ 1:2 ~ 10:0.01 ~ 0.4;
2) prepare eugenol mother solution: in eugenol, add sterilized water, be heated to 30-50 DEG C, add PEG-40, stirring and dissolving is to clarification; Obtain the eugenol mother solution of 40mg/mL;
Tea blend polyphenol mother solution: add sterilized water in tea polyphenols, stirring and dissolving is to clarification; Be prepared into the tea polyphenol mother solution that ultimate density is 40mg/mL;
Preparation Radix Notoginseng mother solution: add sterilized water in Radix Notoginseng extract (20:1), stirring and dissolving is to clarification; Be prepared into the Radix Notoginseng extract mother solution that ultimate density is 20mg/mL;
The preparation of sodium fluoride mother solution: get sodium fluoride and be dissolved in sterilized water, is prepared into the sodium fluoride mother solution that ultimate density is 10mg/mL;
3) above-mentioned four kinds of mother solutions are mixed, and add PEG-40, obtain active component mother solution in collutory;
In described active component mother solution, the weight ratio of tea polyphenols, eugenol, Radix Notoginseng extract, fluoride, PEG-40 is: 0.2 ~ 0.4:0.5 ~ 1:0.17 ~ 0.2:0.05:3 ~ 6;
Under stirring, by step 1) in aqueous solution slowly join step 2) in configuration active component mother solution in, stop stir, after overnight stand, filter, obtain finished product after aseptic process.Wherein, the weight ratio of tea polyphenols and sweeting agent is 0.2 ~ 0.4:0.01 ~ 1, and the concentration of tea polyphenols is 2 ~ 8mg/mL.
Further, in technique scheme, described sweeting agent is selected from one or more in saccharin sodium, Sorbitol, xylitol, fructose, stevioside.
Further, in technique scheme, described acidic flavoring agent is selected from the one in malic acid, citric acid or tartaric acid.
Further, in technique scheme, described wetting agent adopts glycerol or sorbitol; Described essence adopts peafowl essence, menthol.
Further, in technique scheme, described essence adopts peafowl essence, menthol.
Further, in technique scheme, described food antiseptics for Buddhist nun moor second gold ester.
The invention provides the purposes of above-mentioned collutory, this collutory can be used for the oral disease such as treatment or pre-preventing parodontitis, dental caries, halitosis, oral ulcer, has the effect brightening, be good for tooth, clearing heat for detumescence, prophylaxis of cancer.
The using method of this collutory: get this product in right amount, about 10-20ml, rinsing the mouth is about 2-3min, spues.
Invention beneficial effect
Eugenol in the present invention has inhibitory action to malignant bacteria and fungus, also there is antioxidation and certain antitumaous effect, and abnormal smells from the patient is unique, tea polyphenols antibacterial, antioxidant effect is also very good, be widely used in toothpaste, Radix Notoginseng has stronger anti inflammatory blood quickening effect, has fine inhibitory action to the main harmful bacteria that oral cavity is resided in bacterium.Multiple components combines by the present invention, except the function of cleaning oral cavity with different collutory, also has the oral disease such as treatment or pre-preventing parodontitis, dental caries, halitosis, oral ulcer, brighten, is good for effect of tooth, clearing heat for detumescence, prophylaxis of cancer.There is multiple effect of preventing and treating oral disease.This collutory adopts natural plant composition, has better safety than the collutory on existing market.The inventive method is simple, strong operability, is suitable for industrialization and produces.
Accompanying drawing explanation
Fig. 1 is that embodiment 1 collutory is to the inhibition figure of staphylococcus aureus, escherichia coli, bacillus subtilis, Candida albicans;
Fig. 2 is the inhibition figure a of embodiment 1 collutory to Oral Bacteria;
Fig. 3 is the inhibition figure b of embodiment 1 collutory to Oral Bacteria.
Detailed description of the invention
Following nonlimiting examples can make the present invention of those of ordinary skill in the art's comprehend, but does not limit the present invention in any way.Eugenol, is purchased from Jiangxi Cedrus deoclar (Roxb.) G. Don natural medicinal plant oil company limited, density 1.063-1.068g/ml; Tea polyphenols, is purchased from Xuancheng BAICAO plant Trade Co., Ltd.; Radix Notoginseng extract (20:1) is purchased from bright biological development corporation, Ltd. of Baoji side.
Embodiment 1
Preparation method, the production for 100ml:
(1) preparation of effective ingredient mother solution,
The preparation of eugenol mother solution: get 3.756ml eugenol (ρ=1.063 ~ 1.068g/ml), first add a small amount of sterilized water, put into magnetic stirring apparatus to heat while stirring, heating-up temperature is 40 DEG C, add PEG-40 (6 ~ 10ml) gradually to solution clarification, then supplement distilled water to 100ml.Be prepared into the eugenol mother solution that ultimate density is 40mg/mL.
The preparation of tea polyphenol mother solution: get 4g tea polyphenols and be dissolved in 100ml sterilized water, is prepared into the tea polyphenol mother solution that ultimate density is 40mg/mL.
The preparation of Radix Notoginseng extract mother solution: get 2 Radix Notoginseng extracts (20:1) and be dissolved in 100ml sterilized water, is prepared into the Radix Notoginseng extract mother solution that ultimate density is 20mg/mL.
The preparation of sodium fluoride mother solution: get 1g sodium fluoride and be dissolved in 100ml sterilized water, is prepared into the sodium fluoride mother solution that ultimate density is 10mg/mL.
(2) get above-mentioned eugenol mother solution 25ml, tea polyphenol mother solution 5ml, Radix Notoginseng extract mother solution 8.33ml, fluoridize mother solution 5ml, add PEG-401ml gradually and clarify to solution, available ultrasonic dissolution, obtain effective ingredient mother solution mixed liquor;
(3) get 55.67ml sterilized water and add glycerol 5g, K120.5g, Sorbitol 0.01g, malic acid 0.02g, menthol 0.5g, Nipagin ester 0.1g, limit edged stirs to clarify transparent finely dispersed aqueous solution;
(4) under stirring, by step 1) in aqueous solution slowly join step 2) in configuration active component mother solution in, after mix homogeneously, stop stir, after overnight stand, filter, obtain finished product after aseptic process.
Antibacterial test 1
The fungistatic effect of active component in collutory is represented by the growth curve measuring antibacterial, method is: sterile working, adopt the Flos Caryophylli compound recipe collutory obtaining liq culture medium obtained in embodiment 1, do not add the fluid medium of effective ingredient together, take blank cultures as contrast, under 600nm, measure initial OD values.Get the bacterium liquid 3ml of cultivation 8 ~ 12h again, join in aforesaid liquid culture medium, survey an OD value again, as the OD value of 0h, measure an OD value every 2h later, survey again once after surveying 8h, 24h, the OD value in each moment obtained deducts initial absorbance value, does with these numerical value the growth curve that a curve is antibacterial.
To the inhibition of staphylococcus aureus, escherichia coli, bacillus subtilis, Candida albicans in table 1 and Fig. 1:
In table 1 Flos Caryophylli compound recipe collutory, active component is to the inhibition of different bacteria growing
Fig. 2, Fig. 3 are shown in the inhibition of Oral Bacteria: Fig. 2 is the inhibition of collutory to bacterium in certain female oral cavity, Fig. 3 is the inhibition of collutory to bacterium in certain male oral cavity, and wherein negative control is the growing state of Oral Bacteria in the fluid medium containing equal volume normal saline.
Claims (6)
1. a preparation method for Flos Caryophylli compound recipe collutory, is characterized in that comprising the following steps:
1) sweeting agent, acidic flavoring agent and essence are stirred to dissolving in water, then wetting agent and food antiseptics are joined in sterilized water, stir to clarify transparent finely dispersed aqueous solution;
The weight ratio of described sweeting agent, acidic flavoring agent, essence, wetting agent, food antiseptics is 0.01 ~ 1:0.02 ~ 1:0.5 ~ 1:2 ~ 10:0.01 ~ 0.4;
2) prepare eugenol mother solution: in eugenol, add sterilized water, be heated to 30-50 DEG C, add PEG-40, stirring and dissolving is to clarification;
Tea blend polyphenol mother solution: add sterilized water in tea polyphenols, stirring and dissolving is to clarification;
Preparation Radix Notoginseng mother solution: add sterilized water in Radix Notoginseng extract, stirring and dissolving is to clarification;
The preparation of sodium fluoride mother solution: get sodium fluoride and be dissolved in sterilized water;
3) above-mentioned four kinds of mother solutions are mixed, and add PEG-40, obtain active component mother solution in collutory;
In described active component mother solution, the weight ratio of tea polyphenols, eugenol, Radix Notoginseng extract, fluoride, PEG-40 is: 0.2 ~ 0.4:0.5 ~ 1:0.17 ~ 0.2:0.05:3 ~ 6;
Under stirring, by step 1) in aqueous solution slowly join step 2) in configuration active component mother solution in, stop stir, after overnight stand, filter, obtain finished product after aseptic process.Wherein, the weight ratio of tea polyphenols and sweeting agent is 0.2 ~ 0.4:0.01 ~ 1, and the concentration of tea polyphenols is 2 ~ 8mg/mL.
2. preparation method according to claim 1, is characterized in that: described sweeting agent is selected from one or more in saccharin sodium, Sorbitol, xylitol, fructose, stevioside.
3. preparation method according to claim 1, is characterized in that: described acidic flavoring agent is selected from the one in malic acid, citric acid or tartaric acid.
4. preparation method according to claim 1, is characterized in that: described wetting agent adopts glycerol or sorbitol.
5. preparation method according to claim 1, is characterized in that: described essence adopts peafowl essence, menthol.
6. preparation method according to claim 1, is characterized in that: described food antiseptics moors second gold ester for Buddhist nun.
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Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105616324A (en) * | 2016-01-27 | 2016-06-01 | 珠海迈润实业有限公司 | Mouthwash containing plant formula and preparation method thereof |
| CN108014070A (en) * | 2018-02-10 | 2018-05-11 | 广州市九科精细化工有限公司 | Visualization propolis acidity mouthwash of hemostasis and anti-inflammation and preparation method thereof |
| CN108014024A (en) * | 2018-02-10 | 2018-05-11 | 广州市九科精细化工有限公司 | A kind of deep layer removes mouthwash of crock tea stain and preparation method thereof |
| CN108042383A (en) * | 2018-02-10 | 2018-05-18 | 广州市九科精细化工有限公司 | A kind of anti-inflammatory, antibacterial Domiphen bromide mouthwash and preparation method thereof |
| CN108066167A (en) * | 2018-02-10 | 2018-05-25 | 广州市九科精细化工有限公司 | A kind of antibacterial whitening acidity mouthwash of visualization and preparation method thereof |
| CN108066166A (en) * | 2018-02-10 | 2018-05-25 | 广州市九科精细化工有限公司 | Remove acid mouthwash of calculus dentalis and preparation method thereof |
| CN108096047A (en) * | 2018-02-10 | 2018-06-01 | 广州市九科精细化工有限公司 | Domiphen bromide xylitol combination of acidic mouthwash and preparation method thereof |
| CN108186441A (en) * | 2018-02-10 | 2018-06-22 | 广州市九科精细化工有限公司 | A kind of antianaphylactic compound herbal mouthwash of hemostasis and preparation method thereof |
| CN108403544A (en) * | 2018-03-26 | 2018-08-17 | 长沙循源医学科技有限公司 | A kind of Pediatric Oral Emergency care composition and preparation method thereof |
| CN108464965A (en) * | 2018-06-15 | 2018-08-31 | 沈阳药科大学 | A kind of propolis mouthwash and preparation method thereof containing active skull cap components |
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Cited By (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105616324A (en) * | 2016-01-27 | 2016-06-01 | 珠海迈润实业有限公司 | Mouthwash containing plant formula and preparation method thereof |
| CN108014070A (en) * | 2018-02-10 | 2018-05-11 | 广州市九科精细化工有限公司 | Visualization propolis acidity mouthwash of hemostasis and anti-inflammation and preparation method thereof |
| CN108014024A (en) * | 2018-02-10 | 2018-05-11 | 广州市九科精细化工有限公司 | A kind of deep layer removes mouthwash of crock tea stain and preparation method thereof |
| CN108042383A (en) * | 2018-02-10 | 2018-05-18 | 广州市九科精细化工有限公司 | A kind of anti-inflammatory, antibacterial Domiphen bromide mouthwash and preparation method thereof |
| CN108066167A (en) * | 2018-02-10 | 2018-05-25 | 广州市九科精细化工有限公司 | A kind of antibacterial whitening acidity mouthwash of visualization and preparation method thereof |
| CN108066166A (en) * | 2018-02-10 | 2018-05-25 | 广州市九科精细化工有限公司 | Remove acid mouthwash of calculus dentalis and preparation method thereof |
| CN108096047A (en) * | 2018-02-10 | 2018-06-01 | 广州市九科精细化工有限公司 | Domiphen bromide xylitol combination of acidic mouthwash and preparation method thereof |
| CN108186441A (en) * | 2018-02-10 | 2018-06-22 | 广州市九科精细化工有限公司 | A kind of antianaphylactic compound herbal mouthwash of hemostasis and preparation method thereof |
| CN108403544A (en) * | 2018-03-26 | 2018-08-17 | 长沙循源医学科技有限公司 | A kind of Pediatric Oral Emergency care composition and preparation method thereof |
| CN108403544B (en) * | 2018-03-26 | 2021-09-17 | 长沙循源医学科技有限公司 | Oral care composition for children and preparation method thereof |
| CN108464965A (en) * | 2018-06-15 | 2018-08-31 | 沈阳药科大学 | A kind of propolis mouthwash and preparation method thereof containing active skull cap components |
| CN108464965B (en) * | 2018-06-15 | 2021-07-23 | 沈阳药科大学 | Propolis mouthwash containing natural active ingredients and preparation method thereof |
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