CN108014070A - Visualization propolis acidity mouthwash of hemostasis and anti-inflammation and preparation method thereof - Google Patents
Visualization propolis acidity mouthwash of hemostasis and anti-inflammation and preparation method thereof Download PDFInfo
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- CN108014070A CN108014070A CN201810137169.XA CN201810137169A CN108014070A CN 108014070 A CN108014070 A CN 108014070A CN 201810137169 A CN201810137169 A CN 201810137169A CN 108014070 A CN108014070 A CN 108014070A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
- A61K8/987—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of species other than mammals or birds
- A61K8/988—Honey; Royal jelly, Propolis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4993—Derivatives containing from 2 to 10 oxyalkylene groups
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/49—Solubiliser, Solubilising system
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Abstract
The invention discloses a kind of visualization propolis acidity mouthwash of hemostasis and anti-inflammation, component：Sweetener 0.003% ~ 0.1%；Acid 0.01%~0.3%；Moisturizer 2%~15%；Essence 0.05%~0.5%；Activating agent 0.1%~2%；Solubilizer 0.5%~2.5%；Bacteriostatic agent 0.02%~0.05%；Preservative 0.1%~0.4%；Deionized water surplus；The PH of mouthrinse product is 3~5.6th, preparation method includes：Sweetener and acid are added into stirring and dissolving in water deionization, then moisturizer is added in aqueous solution, is stirred evenly；Solubilizer, essence are stirred to form uniform oily solution；Oily solution is added in water miscible clarified solution, is uniformly mixed；Activating agent, bacteriostatic agent, preservative are added in aqueous solution, are mixed evenly；Stand 24 it is small when, filtering, after aseptic process PH be 3~5 mouthwash finished product.To oral cleaning, dispel implication and antibacterial hemostatic function while, repair oral cavity, dispel oral cavity and hemostasis and anti-inflammation one-time-reach-place.
Description
Technical field
A kind of visualization propolis acidity the present invention relates to oral care product technical field, more particularly to hemostasis and anti-inflammation is gargled
Saliva and preparation method thereof.
Background technology
With the improvement of living standards, people increasingly improve the attention rate of oral health, common oral care is also no longer
It is confined to brush teeth twice sooner or later, the species and form demand to oral care product tend to diversification and fashion-orientation.Mouthwash is
Through into the necessity in for people's lives, it is easy to use, and effect can be equal to toothpaste, and use is more convenient than toothpaste, but mesh
The mouthwash of preceding market often act on it is single, and for a long time use protective effect is not had to tooth.It is also, existing at present
The acid-base value of mouthwash be generally neutrality, main function include antibacterial bacteriostatic, improve oral peculiar smell, anti-inflammatory, cleaning oral cavity it is thin
Bacterium and tartar etc., species include Chinese medicine draft class, natural plant extracts class and drug ingedient composite class.
105687083 A of CN disclose a kind of antibacterial hemostasis mouthwash and preparation method thereof, and the mouthwash is by following weight
Raw material be made：0.5~1 part of activated calcium powder, 0.1~2 part of Honegsukle flower P.E, 0.1~1.5 part of propolis, Paeonol 0.2
~0.5 part, 0.1~2 part of deep sea salt, 0.1~0.5 part of mint extract, 0.5~3 part of stevioside, 0.5~1 part of loguat leaf, eucalyptus
0.1~0.3 part of tree oil, 2~3 parts of old tea liquid, 90~95 parts of pure water.Old tea is added in mouthwash of the present invention, it contains abundant
Acid element, capillary hemorrhage can be prevented.There is obvious therapeutic effect to suffering from stomatitis, glossanthrax, eczema, bleeding gums etc..
A kind of Chinese medicine mouth washs of 104688850 A of CN, raw material of the present invention consist predominantly of radix scutellariae, honeysuckle,
The coptis, Fructus Forsythiae, xylitol, 95% ethanol, the ratio of selected raw material use radix scutellariae：Honeysuckle：The coptis：Fructus Forsythiae：Xylitol is 1：
1：0.8：0.8 ：1, extract four kinds of selected Chinese medicines, obtain the extracting solution of radix scutellariae, honeysuckle, the coptis, Fructus Forsythiae, to extracting solution into
Row sterilization treatment, adds xylitol according to ratio and is allocated, be finally made mouthwash.The present invention chooses Chinese herbal medicine and makees
For the raw material of mouthwash, the tradition that mouthwash is prepared using irritation chemicals is breached, quintessence of Chinese culture Chinese medicine has been played and has existed
Unique effects in terms of antibacterial, clearing heat and removing internal heat, and its safety, it is gentle the advantages of.
A kind of long-acting bacteriostatic type mouthwashes of 106038389 A of CN, it at least adds using deionized water as main component
Added with the combination of phellodendron extract, capillary extract, Andrographis Paniculata and Herba Verbenae.This case is extracted using Cortex Phellodendri
The mode that thing, capillary extract, Andrographis Paniculata and Herba Verbenae are used in combination, can play quickly prevents gum from going out
The effect of blood, long-acting suppression oral bacteria, achieve the purpose that to treat both principal and secondary aspect of disease.
105769718 A of CN are a kind of to be used to clean the Chinese medicine mouth wash in oral cavity, is by following weight in the Chinese medicine mouth wash
The Chinese medicine material composition of part proportioning：40~60 parts of kuh-seng, 80~110 parts of Radix Isatidis, 20~40 parts of honeysuckle, rhizoma atractylodis 30~50
Part, 30~40 parts of Verbena officinalis, 30~40 parts of Schisandra chinensis, 15~25 parts of peppermint.This Chinese medicine mouth wash has clearing away heat,cooling blood and removing toxin, resists
The effect of bacterium anti-inflammatory analgesic, is cleaned suitable for mouth cavity daily, while suitable for that can lack of proper care because of bacterium, the position such as oral cavity, throat, tonsillotome
By bacterium, virogenetic infection, and swelling and aching of gum, canker sore, halitosis etc., can make oral cavity thoroughly it is fragrant, clean it is refreshing, comfortable, naturally,
Can long-time service.
Various mouthwashes described in above-mentioned patent, although play the antibacterial anti-inflammatory to tooth and oral cavity, cleaning oral cavity and
Tooth and the effect for being effectively improved oral peculiar smell, but it is substantially neutrality, cleans the effect of tartar and oral foreign body
And unobvious, and oral cavity cannot be repaired, dispel oral cavity and hemostasis and anti-inflammation one-time-reach-place, how effectively, quickly, thoroughly realize
The removing of the adhesion and staining of tooth, while repair oral cavity, dispel oral cavity and hemostasis and anti-inflammation one-time-reach-place, it is to restrict
One problem of the industry of mouth cavity daily nursing at present, and the mouthwash of pure Chinese medicine component primarily serves the effect of reparation, anti-inflammatory,
And the Chinese medicine effect for acting on outside is often slow, for the effect and unobvious of bacteriostasis antibiosis and hemostasis.
The content of the invention
In view of the deficienciess of the prior art, the technical problem to be solved by the invention is to provide it is a kind of to oral cleaning,
While dispelling implication and antibacterial hemostatic function, repair oral cavity, dispel the hemostasis and anti-inflammation of oral cavity and hemostasis and anti-inflammation one-time-reach-place
Visualize propolis acidity mouthwash and preparation method thereof.
In order to solve the above technical problems, the technical solution used in the present invention is：A kind of visualization propolis of hemostasis and anti-inflammation
Acid mouthwash, is made of the component of following percentage by weight：
Sweetener 0.003% ~ 0.1%；
Acid 0.01%~0.3%；
Moisturizer 2%~15%；
Essence 0.05%~0.5%；
Activating agent 0.1%~2%；
Solubilizer 0.5%~2.5%；
Bacteriostatic agent 0.02%~0.05%；
Preservative 0.1%~0.4%；
Deionized water surplus；
The PH of the mouthrinse product is 3~5.
The visualization propolis acidity mouthwash of above-mentioned hemostasis and anti-inflammation, is made of the component of following percentage by weight：
Sweetener 0.05%；；
Acid 0.1%；
Moisturizer 8%；
Essence 0.3%；
Activating agent 1%；
Solubilizer 1.5%；
Bacteriostatic agent 0.03%；
Preservative 0.2%；
Deionized water surplus；
The PH of the mouthrinse product is 4.
The visualization propolis acidity mouthwash of above-mentioned hemostasis and anti-inflammation, the sweetener is saccharin sodium, D-sorbite, trichlorine
One or more in sucrose, acid are citric acid or malic acid, and moisturizer is glycerine, one kind in sorbierite, propane diols
Or it is several, essence is polysorbas20 or PEG-40 hydrogenated castors for the fruit such as green tea, spearmint, honey peach perfume or the fragrance of a flower, solubilizer
Oil, activating agent are the one or more in tea polyphenols, propolis, pseudo-ginseng, and preservative is potassium sorbate, sodium benzoate, methyl hydroxybenzoate
In one or more, bacteriostatic agent uses Domiphen bromide, western pyrrole chloramines or chlorohexidene.
The visualization propolis acidity mouthwash of above-mentioned hemostasis and anti-inflammation, the mouthwash are also added with percentage by weight
0.5% coolant agent.
The visualization propolis acidity mouthwash of above-mentioned hemostasis and anti-inflammation, the coolant agent are menthol.
A kind of method for the visualization propolis acidity mouthwash for preparing hemostasis and anti-inflammation, includes the following steps：
（1）, sweetener and acid are added to stirring and dissolving in water deionization, then moisturizer is added in aqueous solution, stirring is equal
It is even and form finely dispersed water miscible clarified solution；
（2）, solubilizer, essence stirred to form uniform oily solution；
（3）, in the state of stirring, oily solution is slowly added into water miscible clarified solution, be uniformly mixed；
（4）, by activating agent, bacteriostatic agent, preservative add step（3）In the aqueous solution of acquisition, it is mixed evenly；
（5）, stop stirring, stand 24 it is small when, filtering, after aseptic process PH be 3~5 mouthwash finished product.
The preparation method of the visualization propolis acidity mouthwash of above-mentioned hemostasis and anti-inflammation, the step（2）Middle addition weight
Percentage is 0.5% coolant agent.
The preparation method of the visualization propolis acidity mouthwash of above-mentioned hemostasis and anti-inflammation, the sweetener is saccharin sodium, mountain
One or more in pears sugar alcohol, Sucralose, acid are citric acid or malic acid, moisturizer is glycerine, sorbierite, the third two
One or more in alcohol, essence are polysorbas20 or PEG- for the fruit such as green tea, spearmint, honey peach perfume or the fragrance of a flower, solubilizer
40 rilanit specials, activating agent are the one or more in tea polyphenols, propolis, pseudo-ginseng, and preservative is potassium sorbate, benzoic acid
One or more in sodium, methyl hydroxybenzoate, bacteriostatic agent use Domiphen bromide, western pyrrole chloramines or chlorohexidene.
The preparation method of the visualization propolis acidity mouthwash of above-mentioned hemostasis and anti-inflammation, the coolant agent is menthol.
The advantages of visualization propolis acidity mouthwash of hemostasis and anti-inflammation of the present invention and preparation method thereof is：Addition it is acid into
Point, to oral cleaning, dispel implication and antibacterial hemostatic function while, repair oral cavity, dispel oral cavity and hemostasis and anti-inflammation once arrives
Position.Mouthwash of the present invention is applied widely, easy to use, has the function that cleaning, antibacterial, anti-caries and fresh breath, and nothing is appointed
What toxic side effect；Meanwhile, it is capable to promote the calcification of tooth, bleeding gums are prevented.Tea polyphenols, propolis, pseudo-ginseng are added, hair can be prevented
Thin angiorrbagia.There is obvious therapeutic effect to suffering from stomatitis, glossanthrax, eczema, bleeding gums etc..Tea polyphenols, propolis, pseudo-ginseng,
The effect of mode that solubilizer is used in combination, can play quickly prevents bleeding gums, long-acting suppression oral bacteria, reaches sample
The simultaneous purpose controlled.The component of this mouthwash is green and healthy raw material, and formula is unique, fastidious, manufacture method is simple, through excessive
Secondary clinical research, there is uniqueness to resist the oral inflammation caused by the pathogenic bacteria such as Candida albicans, staphylococcus aureus
Bacterium anti-inflammatory, analgesic promoting muscle growth functions, can effectively suppress the formation of oral inflammation, maintain Oral Bacteria state balance, moment cleaning oral cavity, prevents
It is good to control effect.
Embodiment
The present invention is described in further details with reference to specific embodiment；
Embodiment 1：
A kind of visualization propolis acidity mouthwash of hemostasis and anti-inflammation, is made of the component of following percentage by weight：Sweetener
0.003%；Acid 0.01%；Moisturizer 2%；Essence 0.05%；Activating agent 0.1%；Solubilizer 0.5%；Bacteriostatic agent 0.02%；It is anti-
Rotten agent 0.1%；Deionized water surplus；The PH of the mouthrinse product is 5.Wherein, sweetener for saccharin sodium, D-sorbite, tart flavour
Agent is citric acid, and moisturizer is glycerine, sorbierite, and essence is green tea, the fragrance of a flower, and solubilizer is polysorbas20, activating agent is tea polyphenols,
Propolis, preservative is potassium sorbate, sodium benzoate, and bacteriostatic agent uses Domiphen bromide.The mouthwash is also added with percentage by weight
For 0.5% coolant agent.In the present embodiment, coolant agent is menthol.
The method that the present invention prepares the visualization propolis acidity mouthwash of hemostasis and anti-inflammation, includes the following steps：
（1）, sweetener and acid are added to stirring and dissolving in water deionization, then moisturizer is added in aqueous solution, stirring is equal
It is even and form finely dispersed water miscible clarified solution；
（2）, solubilizer, essence, 0.5% coolant agent stirred to form uniform oily solution；
（3）, in the state of stirring, oily solution is slowly added into water miscible clarified solution, be uniformly mixed；
（4）, by activating agent, bacteriostatic agent, preservative add step（3）In the aqueous solution of acquisition, it is mixed evenly；
（5）, stop stirring, stand 24 it is small when, filtering, after aseptic process PH be 5 mouthwash finished product.
The sweetener is saccharin sodium, D-sorbite, and acid is citric acid, and moisturizer is glycerine, sorbierite, and essence is
Green tea, the fragrance of a flower, solubilizer are polysorbas20, and activating agent is tea polyphenols, propolis, and preservative is potassium sorbate, sodium benzoate, bacteriostatic agent
Using Domiphen bromide.The mouthwash is also added with the coolant agent that percentage by weight is 0.5%.In the present embodiment, coolant agent is peppermint
Alcohol.
Embodiment 2：
A kind of visualization propolis acidity mouthwash of hemostasis and anti-inflammation, is made of the component of following percentage by weight：Sweetener
0.05%；Acid 0.1%；Moisturizer 8%；Essence 0.3%；Activating agent 1%；Solubilizer 1.5%；Bacteriostatic agent 0.03%；Preservative
0.2%；Deionized water surplus；The PH of the mouthrinse product is 4.Wherein, sweetener for D-sorbite, Sucralose, acid
For malic acid, moisturizer is sorbierite, propane diols, and essence is the spearmint fragrance of a flower, and solubilizer is Cremophor RH40, activity
Agent is propolis, in pseudo-ginseng, and preservative is sodium benzoate, methyl hydroxybenzoate, and bacteriostatic agent uses western pyrrole chloramines.Mouthwash is also added with weight
Percentage is measured as 0.5% coolant agent, in the present embodiment, coolant agent is menthol.
The method that the present invention prepares the visualization propolis acidity mouthwash of hemostasis and anti-inflammation, includes the following steps：
（1）, sweetener and acid are added to stirring and dissolving in water deionization, then moisturizer is added in aqueous solution, stirring is equal
It is even and form finely dispersed water miscible clarified solution；
（2）, solubilizer, essence, 0.5% coolant agent stirred to form uniform oily solution；
（3）, in the state of stirring, oily solution is slowly added into water miscible clarified solution, be uniformly mixed；
（4）, by activating agent, bacteriostatic agent, preservative add step（3）In the aqueous solution of acquisition, it is mixed evenly；
（5）, stop stirring, stand 24 it is small when, filtering, after aseptic process PH be 4 mouthwash finished product.
Wherein, sweetener is D-sorbite, Sucralose, and acid is malic acid, and moisturizer is sorbierite, propane diols,
Essence is the spearmint fragrance of a flower, and solubilizer is Cremophor RH40, and activating agent is propolis, in pseudo-ginseng, and preservative is benzoic acid
Sodium, methyl hydroxybenzoate, bacteriostatic agent use western pyrrole chloramines.Mouthwash is also added with the coolant agent that percentage by weight is 0.5%, this implementation
In example, coolant agent is menthol.
Embodiment 3：
A kind of visualization propolis acidity mouthwash of hemostasis and anti-inflammation, is made of the component of following percentage by weight：Sweetener 0.1%；
Acid 0.3%；Moisturizer 15%；Essence 0.5%；Activating agent 2%；Solubilizer 2.5%；Bacteriostatic agent 0.05%；Preservative 0.4%；Go
Ion water surplus；The PH of the mouthrinse product is 3.Wherein, sweetener is saccharin sodium, Sucralose, and acid is citric acid,
Moisturizer is glycerine, propane diols, and essence is fragrant for honey peach fruit, and solubilizer is polysorbas20, and activating agent is tea polyphenols, pseudo-ginseng, is prevented
Rotten agent is potassium sorbate, methyl hydroxybenzoate, and bacteriostatic agent uses chlorohexidene.Mouthrinse components are also added with weight percent in the present embodiment
Than the coolant agent for 0.5%, the coolant agent is menthol.
The method that the present invention prepares the visualization propolis acidity mouthwash of hemostasis and anti-inflammation, includes the following steps：
（1）, sweetener and acid are added to stirring and dissolving in water deionization, then moisturizer is added in aqueous solution, stirring is equal
It is even and form finely dispersed water miscible clarified solution；
（2）, solubilizer, essence, 0.5% coolant agent stirred to form uniform oily solution；
（3）, in the state of stirring, oily solution is slowly added into water miscible clarified solution, be uniformly mixed；
（4）, by activating agent, bacteriostatic agent, preservative add step（3）In the aqueous solution of acquisition, it is mixed evenly；
（5）, stop stirring, stand 24 it is small when, filtering, after aseptic process PH be 3 mouthwash finished product.
Wherein, sweetener is saccharin sodium, Sucralose, and acid is citric acid, and moisturizer is glycerine, propane diols, essence
Fragrant for honey peach fruit, solubilizer is polysorbas20, and activating agent is tea polyphenols, pseudo-ginseng, and preservative is potassium sorbate, methyl hydroxybenzoate,
Bacteriostatic agent uses chlorohexidene.Mouthrinse components are described cool also added with the coolant agent that percentage by weight is 0.5% in the present embodiment
Taste agent is menthol.
Certainly, it is limitation of the present invention that described above, which is not, and the present invention is also not limited to the example above, the art
Those of ordinary skill, in the essential scope of the present invention, the variations, modifications, additions or substitutions made, should all belong to the present invention
Protection domain.
Claims (9)
1. the visualization propolis acidity mouthwash of a kind of hemostasis and anti-inflammation, it is characterised in that by the component group of following percentage by weight
Into：
Sweetener 0.003% ~ 0.1%；
Acid 0.01%~0.3%；
Moisturizer 2%~15%；
Essence 0.05%~0.5%；
Activating agent 0.1%~2%；
Solubilizer 0.5%~2.5%；
Bacteriostatic agent 0.02%~0.05%；
Preservative 0.1%~0.4%；
Deionized water surplus；
The PH of the mouthrinse product is 3~5.
2. the visualization propolis acidity mouthwash of hemostasis and anti-inflammation according to claim 1, it is characterized in that, by following weight hundred
Divide the component composition of ratio：
Sweetener 0.05%；
Acid 0.1%；
Moisturizer 8%；
Essence 0.3%；
Activating agent 1%；
Solubilizer 1.5%；
Bacteriostatic agent 0.03%；
Preservative 0.2%；
Deionized water surplus；
The PH of the mouthrinse product is 4.
3. the visualization propolis acidity mouthwash of hemostasis and anti-inflammation according to claim 1, it is characterized in that：The sweetener is
One or more in saccharin sodium, D-sorbite, Sucralose, acid are citric acid or malic acid, and moisturizer is glycerine, mountain
One or more in pears alcohol, propane diols, essence are tween for the fruit such as green tea, spearmint, honey peach perfume or the fragrance of a flower, solubilizer
20 or Cremophor RH40, activating agent is tea polyphenols, propolis, the one or more in pseudo-ginseng, preservative is potassium sorbate,
One or more in sodium benzoate, methyl hydroxybenzoate, bacteriostatic agent use Domiphen bromide, western pyrrole chloramines or chlorohexidene.
4. the visualization propolis acidity mouthwash of hemostasis and anti-inflammation according to claim 1, it is characterized in that：The mouthwash is also
Added with the coolant agent that percentage by weight is 0.5%.
5. the visualization propolis acidity mouthwash of hemostasis and anti-inflammation according to claim 4, it is characterized in that：The coolant agent is
Menthol.
A kind of 6. method for the visualization propolis acidity mouthwash for preparing hemostasis and anti-inflammation, it is characterised in that include the following steps：
（1）, sweetener and acid are added to stirring and dissolving in water deionization, then moisturizer is added in aqueous solution, stirring is equal
It is even and form finely dispersed water miscible clarified solution；
（2）, solubilizer, essence stirred to form uniform oily solution；
（3）, in the state of stirring, oily solution is slowly added into water miscible clarified solution, be uniformly mixed；
（4）, by activating agent, bacteriostatic agent, preservative add step（3）In the aqueous solution of acquisition, it is mixed evenly；
（5）, stop stirring, stand 24 it is small when, filtering, after aseptic process PH be 3~5 mouthwash finished product.
7. the preparation method of the visualization propolis acidity mouthwash of hemostasis and anti-inflammation according to claim 6, it is characterized in that：Institute
State step（2）The coolant agent that middle addition percentage by weight is 0.5%.
8. the preparation method of the visualization propolis acidity mouthwash of hemostasis and anti-inflammation according to claim 6, it is characterized in that：Institute
Sweetener is stated as saccharin sodium, D-sorbite, the one or more in Sucralose, acid is citric acid or malic acid, moisturizing
Agent is glycerine, sorbierite, the one or more in propane diols, essence for the fruit such as green tea, spearmint, honey peach are fragrant or the fragrance of a flower,
Solubilizer is polysorbas20 or Cremophor RH40, and activating agent is tea polyphenols, propolis, the one or more in pseudo-ginseng, anti-corrosion
Agent is potassium sorbate, sodium benzoate, the one or more in methyl hydroxybenzoate, and bacteriostatic agent is using Domiphen bromide, western pyrrole chloramines or wash must
It is safe.
9. the preparation method of the visualization propolis acidity mouthwash of hemostasis and anti-inflammation according to claim 7, it is characterized in that：Institute
It is menthol to state coolant agent.
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| CN201810137169.XA CN108014070A (en) | 2018-02-10 | 2018-02-10 | Visualization propolis acidity mouthwash of hemostasis and anti-inflammation and preparation method thereof |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108464965A (en) * | 2018-06-15 | 2018-08-31 | 沈阳药科大学 | A kind of propolis mouthwash and preparation method thereof containing active skull cap components |
| CN109620743A (en) * | 2019-01-17 | 2019-04-16 | 威莱(广州)日用品有限公司 | A kind of mouthwash and preparation method thereof containing acid fungicide |
| CN113499272A (en) * | 2021-09-05 | 2021-10-15 | 广州市九叶化妆品有限公司 | Chlorhexidine gluconate-containing mouthwash and preparation method thereof |
| WO2022088724A1 (en) * | 2020-10-28 | 2022-05-05 | 南京中科游子生物技术研究院有限公司 | Green tea active substance mouthwash composition and preparation method therefor |
| CN114917320A (en) * | 2022-04-18 | 2022-08-19 | 重庆功存科技有限公司 | Oral bacteriostatic spray synthesized by panax notoginseng saponins and tea polyphenol |
| WO2024016109A1 (en) * | 2022-07-18 | 2024-01-25 | 南京中科游子生物技术研究院有限公司 | Oral care composition of tea active substance and method for preparing same |
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108464965A (en) * | 2018-06-15 | 2018-08-31 | 沈阳药科大学 | A kind of propolis mouthwash and preparation method thereof containing active skull cap components |
| CN108464965B (en) * | 2018-06-15 | 2021-07-23 | 沈阳药科大学 | Propolis mouthwash containing natural active ingredients and preparation method thereof |
| CN109620743A (en) * | 2019-01-17 | 2019-04-16 | 威莱(广州)日用品有限公司 | A kind of mouthwash and preparation method thereof containing acid fungicide |
| WO2022088724A1 (en) * | 2020-10-28 | 2022-05-05 | 南京中科游子生物技术研究院有限公司 | Green tea active substance mouthwash composition and preparation method therefor |
| CN113499272A (en) * | 2021-09-05 | 2021-10-15 | 广州市九叶化妆品有限公司 | Chlorhexidine gluconate-containing mouthwash and preparation method thereof |
| CN114917320A (en) * | 2022-04-18 | 2022-08-19 | 重庆功存科技有限公司 | Oral bacteriostatic spray synthesized by panax notoginseng saponins and tea polyphenol |
| WO2024016109A1 (en) * | 2022-07-18 | 2024-01-25 | 南京中科游子生物技术研究院有限公司 | Oral care composition of tea active substance and method for preparing same |
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