CN109620743A - A kind of mouthwash and preparation method thereof containing acid fungicide - Google Patents
A kind of mouthwash and preparation method thereof containing acid fungicide Download PDFInfo
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- CN109620743A CN109620743A CN201910046403.2A CN201910046403A CN109620743A CN 109620743 A CN109620743 A CN 109620743A CN 201910046403 A CN201910046403 A CN 201910046403A CN 109620743 A CN109620743 A CN 109620743A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/20—Halogens; Compounds thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/02—Local antiseptics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
The invention belongs to daily chemical product technical fields, and in particular to a kind of mouthwash and preparation method thereof containing acid fungicide.Mouthwash of this life containing acid fungicide includes that following parts by weight meter prepares raw material: 75~86 parts of hypochloric acid water solution, 0.5~3.0 part of edible ethanol, 0.5~2.5 part of moisturizer, 0.5~3.0 part of surfactant, 2.0~3.0 parts of sweetener, 1~5 part of pulullan polysaccharide, 0.1~0.5 part of edible pigment and 6~10 parts of water.Mouthwash of the present invention contains this acid fungicide of chloric acid aqueous solution, has excellent bactericidal property, can kill the pathogenic bacteria such as Escherichia coli, Candida albicans, keeps oral cleaning health, while nontoxic, non-stimulated, stable system, safety can be used for a long time.
Description
Technical field
The invention belongs to daily chemical product technical fields, and in particular to a kind of mouthwash and its preparation side containing acid fungicide
Method.
Background technique
Hypochloric acid water solution also known as hypochlorous acid electrolysis water are developed the 1990s by Japan, are one kind with secondary
Chloric acid be main sterilization component acidic aqueous solution, have sterilizing ability is strong, bactericidal range is wide, pollution-free, noresidue, safety,
Reliably, non-toxic to humans, do not stimulate skin, produce conveniently, lower-price characteristic.It begins with scholar within 1997 and studies it
Bactericidal effect and safety etc., 2002, hypochlorous acid electrolysis water was designated as food bactericide in Japan, later its food,
It comes into operation in the fields such as herding, agricultural.
Hypochlorous acid electrolysis water generating principle be the dilute hydrochloric acid of appropriate low concentration and (or) sodium chloride solution have been added to every
In film or undivided cell, by electrolysis, chlorine and hydrogen ion are generated in anode, hydrogen ion, which is dissolved in water, makes water in acidity, chlorine
Gas is reacted with water generates hydrochloric acid and hypochlorous acid, and cathode generates hydrogen.Chloric acid electrolysis water is divided into highly acid hypochlorous acid according to pH value again
Electrolysis water (pH is 2.0~3.0) and subacidity hypochlorous acid electrolysis water (pH is 5.0~6.5).Highly acid hypochlorous acid electrolysis water is killed
Bacterium has excellent performance, smaller on human and environment influence, can be used for the disinfection of surgical instrument and scope, but because of its highly acid, to gold
Accessory has corrosiveness and can make sclerous tissues' demineralization in oral cavity, limits it in the application in oral cavity field.And subacidity hypochlorous acid
Electrolysis water pH value has higher-security close to neutrality, small to carrying capacity of environment, has applications well prospect in oral cavity field.
Currently, existing research carries out oral cleaning to dental patients using subacidity hypochlorous acid electrolysis water, after finding use
The sterilizing rate of the pathogenic bacteria such as dental patients oral cavity enterococcus faecalis and Streptococcus mutans is obviously improved.But on the one hand
The stability of subacidity hypochlorous acid electrolysis water is poor, is easy to be illuminated by the light, air, time and contact impurity etc. influence, and sterilization is caused to be imitated
Fruit declines or is difficult to persistently, it is therefore desirable to using be protected from light, container storage made of closed herd polyvinyl chloride material, and use
Process need to reduce number of uncapping；Another aspect subacidity hypochlorous acid electrolysis water has certain corrosivity to metals such as aluminium, copper, can give
The routine use of people makes troubles.Therefore, subacidity hypochlorous acid electrolysis water focuses primarily upon clinical application at present, rarely seen to have
The dental care products such as mouthwash are converted in market circulation, this constrains the production of subacidity hypochlorous acid electrolysis water oral care significantly
The application and popularization of product.
Therefore, in order to promote subacidity hypochlorous acid electrolysis water oral care product application and promote, it is necessary to compound out
The suitable aqueous systems of gargling of one kind maintain its excellent bactericidal effect, together to improve the stability of subacidity hypochlorous acid electrolysis water
When reduce its corrosivity, be convenient for people's routine use.
In order to make mouthwash that there is good appearance, promote people's consumption, it will usually use transparent wrapper bottle, and gargle
Pigment is added in saliva.Existing food grade colorant includes synthetic dyestuff and natural pigment, and natural pigment is highly-safe, but is existed steady
Qualitative difference, to light, thermo-responsive disadvantage, and mouthwash is substantially and is packed using transparent plastic bottle, so fresh in mouthwash
See the application for having natural food colour.Gardenia Yellow (No. CAS is 94238-00-3) is using cape jasmine fruit as raw material, by mentioning
Natural food colour made of taking, separate, being concentrated, drying is mainly used as food color, and dieing activity is good, bright in colour.Through
Retrieval, it is not yet found that Gardenia Yellow is applied to the research in mouthwash as pigment.
Summary of the invention
In order to solve the problems in the existing technology (as follows the stability of chloric acid aqueous solution is poor, there is no containing hypochlorous acid
The mouthrinse product etc. of aqueous solution), the present invention provides a kind of mouthwash, which contains chloric acid aqueous solution this acidity and kills
Microbial inoculum, and the light of chloric acid aqueous solution, thermal stability are significantly improved, maintain killing to oral cavity pathogen for chloric acid aqueous solution
Bacterium effect, and appearance luster is bright-coloured, stable system, safety.
Mouthwash provided by the invention containing acid fungicide prepares raw material including following parts by weight meter: hypochloric acid water
75~86 parts of solution, 0.5~3.0 part of edible ethanol, 0.5~2.5 part of moisturizer, 0.5~3.0 part of surfactant, sweetener
2.0~3.0 parts, 1~5 part of pulullan polysaccharide, 0.1~0.5 part of edible pigment and 6~10 parts of water.
Preferably, mouthwash of the present invention further includes that following parts by weight meter prepares raw material: 0.05~0.15 part of sodium fluoride.
Preferably, mouthwash of the present invention further includes that following parts by weight meter prepares raw material: 0.5~1.0 part of edible essence.
Preferably, the moisturizer is glycerol.
Preferably, the surfactant is Tween-20.
Preferably, the sweetener is xylitol.
Preferably, the edible pigment is Gardenia Yellow.
Preferably, the hypochloric acid water solution is subacidity hypochlorous acid electrolysis water, and effective chlorine density is 40~200mg/L,
PH value is 4.5~6.5, Yangization Hai original electricity Wei≤600mV.
Correspondingly, the present invention also provides the preparation methods of the above-mentioned mouthwash containing acid fungicide, comprising the following steps:
S1, moisturizer, surfactant and the sweetener that formula ratio is added into the ethyl alcohol of formula ratio, stir evenly, make
Obtain solution A；
S2, the pulullan polysaccharide and edible pigment that formula ratio is added into the water of formula ratio, stir evenly, obtained solution B；
S3, the hypochloric acid water solution of formula ratio is mixed with solution A, solution B, is stirred evenly, is made containing acid fungicide
Mouthwash.
It further, further include 0.05~0.15 part of sodium fluoride be added in parts by weight in the step S1.
It further, further include 0.5~1.0 part of edible essence be added in parts by weight in the step S1.
In order to improve the stability of hypochloric acid water solution, mouthrinse product is converted it into, inventor is on mouthwash basis
Pulullan polysaccharide is introduced in formula, it has unexpectedly been found that pulullan polysaccharide can significantly improve the stability of chloric acid aqueous solution, make it
Dental care products are suitable as to circulate on the market.Speculate the long-chain macromolecule knot this is because pulullan polysaccharide high-sequential
Structure, the molecules such as cooperation moisturizer, surfactant form cross network structure, enable hypochlorous acid small molecule in reticular structure
It keeps stablizing, slows down electrolysis and decomposition reaction, maintain bactericidal effect, while reducing to corrosion of metal.But pulullan polysaccharide
Additive amount should not be excessive, and aqueous systems of otherwise gargling are sticky, is not easy to pour out use.
But found in carrying out exposure experiments to light, the mouthrinse product is unstable to illumination, and shading is needed to save or use
Coloured plastics material bottle packaging, this can leverage the desire to purchase of consumer, and also be unfavorable for routine use.Gardenia Yellow
Aqueous solution be in yellow, tone is hardly influenced by environmental pH variation, light, thermal stability under neutral and alkaline condition
Preferably, but in acid condition light, thermal stability are deteriorated, easy brown stain.Inventor is made an addition in mouthwash basic components, then
Hypochloric acid water solution is added, under illumination condition, which has occurred brown stain, and muddiness occurs, and adds Propiram
After polysaccharide, light, the thermal stability of mouthwash all obtain significant raising.Therefore, pulullan polysaccharide is cooperateed with Gardenia Yellow,
The stability of the mouthwash containing hypochloric acid water solution is improved jointly, and it is made to obtain bright-coloured yellow coloration.
Therefore, compared with prior art, present invention has an advantage that
(1) the present invention provides a kind of new mouthrinse products, and containing chloric acid aqueous solution, this acid fungicide, has
Excellent bactericidal property can kill the pathogenic bacteria such as Escherichia coli, Candida albicans, staphylococcus aureus, pseudomonas aeruginosa,
Oral cleaning health is kept, while nontoxic, non-stimulated, can be used for a long time.
(2) formula system of the mouthwash of the invention containing acid fungicide is stablized, and is convenient for storage and transport, and appearance luster is fresh
It is gorgeous, while preparation method is simple, process stabilizing, it is at low cost, environmentally protective, there are good market prospects.
Specific embodiment
The following describes the present invention further through the description of specific embodiments.
The mouthwash and preparation method thereof of embodiment, the present invention containing acid fungicide
The formula of mouthwash of the embodiment of the present invention 1~5 containing acid fungicide is as shown in table 1 below.
Table 1
Above-mentioned hypochloric acid water solution is subacidity hypochlorous acid electrolysis water, and effective chlorine density is 40~200mg/L, and pH value is
4.5~6.5, Yangization Hai original electricity Wei≤600mV.
The preparation method of mouthwash of the embodiment of the present invention 1~5 containing acid fungicide, comprising the following steps:
S1, glycerol, Tween-20, xylitol, sodium fluoride, the edible essence that formula ratio is added into the ethyl alcohol of formula ratio, are stirred
It mixes uniformly, obtained solution A；
S2, the pulullan polysaccharide and Gardenia Yellow that formula ratio is added into the water of formula ratio, stir evenly, obtained solution
B；
S3, the hypochloric acid water solution of formula ratio is mixed with solution A, solution B, is stirred evenly, is made containing acid fungicide
Mouthwash.
The effective chlorine density and pH value of mouthwash of the Examples 1 to 5 containing acid fungicide are as shown in table 2 below.
Table 2
| Project | Embodiment 1 | Embodiment 2 | Embodiment 3 | Embodiment 4 | Embodiment 5 |
| Effective chlorine density | 80mg/L | 40mg/L | 100mg/L | 140mg/L | 120mg/L |
| PH value | 5.5 | 6.5 | 6.0 | 5.0 | 6.0 |
The formula of 1~4 mouthwash of comparative example is as shown in table 3 below.
Table 3
| Raw material | Comparative example 1 | Comparative example 2 | Comparative example 3 | Comparative example 4 |
| Hypochloric acid water solution | 81.4kg | 80.4kg | 81.1kg | 80.1kg |
| Edible ethanol | 2.0kg | 2.0kg | 2.0kg | 5.0kg |
| Glycerol | 2.0kg | 2.0kg | 2.0kg | 4.0kg |
| Tween-20 | 1.5kg | 1.5kg | 1.5kg | 1.5kg |
| Xylitol | 2.5kg | 2.5kg | 2.5kg | 2.5kg |
| Pulullan polysaccharide | / | 3kg | / | 3kg |
| Gardenia Yellow | / | / | 0.3kg | 0.3kg |
| Water | 10kg | 8kg | 10kg | 3kg |
| Edible essence | 0.6kg | 0.6kg | 0.6kg | 0.6kg |
| Effective chlorine density | 100mg/L | 100mg/L | 100mg/L | 100mg/L |
| PH value | 6.0 | 6.0 | 6.0 | 6.0 |
The preparation method reference implementation example of comparative example mouthwash.
The bactericidal effect test of test example one, the mouthwash of the invention containing acid fungicide
1, test material: Escherichia coli (8099), Candida albicans (ATCC 10231), staphylococcus aureus
(ATCC6538), pseudomonas aeruginosa (ATCC 15442), bacillus subtilis black variety gemma (ATCC 9372), neutralizer
(physiological saline of 0.1% tween), phosphate buffer (0.03mol/L, pH value 7.2), bovine serum albumin(BSA) (BSA), pancreas egg
White old soy agar culture medium, sabouraud culture medium, nutrient agar etc..
2, test method: use hypochloric acid water solution (effective chlorine density 100mg/L, pH value 6.0) as control, root
According to " disinfection technology standard " suspension method, the bactericidal effect of testing example 3,5 mouthwash of embodiment and hypochloric acid water solution.
3, result is as shown in table 4 below.
Table 4
By upper table 4 it is found that mouthwash of the present invention containing acid fungicide is to Escherichia coli, Candida albicans, golden yellow Portugal
The pathogenic bacteria such as grape coccus, pseudomonas aeruginosa, bacillus subtilis black variety gemma have ideal killing effect, and it is sterilized
Effect is suitable with the hypochloric acid water solution of identical effective chlorine density, and the auxiliary material of mouthwash of the present invention is prompted to imitate hypochlorous sterilization
Fruit is substantially without influence.
The toxicology test of test example two, the mouthwash of the invention containing acid fungicide
Examples 1 to 5 mouthwash is surveyed according to the test of " disinfection technology standard " acute oral poison, Skin Irritation Test
Examination carries out overall merit with tested material animal LD50 and an intact skin irritant test, observes its toxic effect.
Show through toxicology test:
The acute oral poison test result of Examples 1 to 5 mouthwash are as follows: practical nontoxic grade, LD50 >=5000mg/kg；
Intact skin irritant test result of Examples 1 to 5 mouthwash: 0~< of skin irritation index 0.5 belongs to nothing
Irritation rank.
Therefore, mouthwash of the present invention containing acid fungicide is nontoxic, nonirritant, and various people is suitble to use.
The erosion test of test example three, the mouthwash of the invention containing acid fungicide
1, material: round, diameter 24.0mm, thick 1.0mm, wearing a diameter is 2.0mm aperture, and surface area total value is about
9.80cm2(including upper and lower, periphery surface and aperture side), finish 6.Raw material is as follows: (specification is shown in GB/T700- to carbon steel
65)；Aluminium (specification is shown in GB/T 1173-74).
2, it test method: is tested by " disinfection technology standard " metal protection, in the detergent for having surface-active action
10min is impregnated, is sufficiently deoiled, is cleaned；By highest, using concentration test preparation sample, (Examples 1 to 4 and comparative example 3~4 are gargled
The hypochloric acid water solution that saliva, effective chlorine density 100mg/L, pH value are 6.0), to soak test print.When immersion, often
One sheet metal need to be immersed in the oxide layer for grinding off sheet metal two sides and periphery surface in 200ml sample with No. 120 granularity waterproof abrasive papers,
It is washed down again with tap water.Measure diameter, the thickness, aperture (being accurate to 0.1mm) of piece.It is taken off again with anhydrous propanone or dehydrated alcohol
Rouge.Dry 1h in 50 DEG C of insulating boxs is set, is cooled to room temperature weighing to its temperature, every sheet metal is weighed 3 times after balance returns to zero, essence
Really to 0.1mg, take its average value as weight before testing.When weighing, cleaning gloves should be worn, print is not contacted directly with hand.
3, test result is as follows shown in table 5.
Table 5
From upper table 5: compared with hypochloric acid water solution and comparative example 3 (not pullulan-containing), the present invention is containing acid
Property fungicide mouthwash the corrosivity of aluminium flake, carbon steel coupon is substantially reduced, prompt pulullan polysaccharide can subtract to a certain extent
Delay hypochlorous acid to corrosions of metal such as aluminium, carbon steels.Comparative example 4 changes the content of part material, and as a result it is to aluminium flake, carbon steel coupon
Corrosivity increase, prompt other raw materials and content that can have an impact to the corrosion inhibition of pulullan polysaccharide.
The stability test of test example four, the mouthwash of the invention containing acid fungicide
Thermal stability accelerated test: the accelerated test in reference " disinfection technology standard " sterile products Stability Determination,
The sample (1~4 mouthwash of Examples 1 to 5 and comparative example) for taking commercially available back good, is placed in 37 DEG C of insulating boxs and is protected from light 3 months.In
It places and forward and backward measures available chlorine content respectively.Each test sample is three batches, and sample repeats to survey 2 times, takes its average value.
Photostability accelerated test: the sample (1~4 mouthwash of Examples 1 to 5 and comparative example) for taking commercially available back good is placed in
It in lighting box, places 10 days under conditions of illumination is 4500lx, temperature is 20 DEG C, is observed every sampling in 2 days, record appearance becomes
Change situation, and in the 10th day measurement available chlorine content.
Effective chlorine test method is according to " disinfection technology standard " 4.3.4.2.1.Available chlorine content rate of descent=[(experiment opening
Available chlorine content when available chlorine content-off-test when the beginning)/on-test when available chlorine content] × 100%.As a result such as the following table 6
It is shown.
Table 6
From upper table 6:
(1) mouthwash of the embodiment of the present invention 1~5 containing acid fungicide accelerates examination by thermal stability and photostability
It tests, shows excellent stability, bactericidal active ingredient hypochlorous acid content rate of descent is lower than 10%, and appearance is normal, no layering,
The bad phenomenons such as precipitating, muddiness, and bright-coloured yellow is kept, can estimate its shelf-life is 2 years.
(2) compared with Example 3, comparative example 1 does not contain pulullan polysaccharide and Gardenia Yellow, is colourless transparent liquid,
As a result after overheat and acceleration by light test, hypochlorous acid content declines to a great extent, and system becomes white opacity solution.With comparative example
1 compares, and comparative example 2 is added to pulullan polysaccharide, and thermal stability significantly improves, but photostability is poor；And comparative example 3 is added to
Gardenia Yellow, in the case where not adding pulullan polysaccharide, stability is no different with comparative example 1；Comparative example 4 changes part
The content of raw material, hypochlorous acid content are decreased obviously, and system yellow brown stain；Prompt is in inventive formulation system, Pu Lu
Blue polysaccharide can not only improve hypochlorous stability, can also improve the stability of Gardenia Yellow, to reinforce the light of mouthwash
Stability.
The above is only the preferred embodiment of the present invention, it is noted that above-mentioned preferred embodiment is not construed as pair
Limitation of the invention, protection scope of the present invention should be defined by the scope defined by the claims..For the art
For those of ordinary skill, without departing from the spirit and scope of the present invention, several improvements and modifications can also be made, these change
It also should be regarded as protection scope of the present invention into retouching.
Claims (10)
1. a kind of mouthwash containing acid fungicide, which is characterized in that prepare raw material including following parts by weight meter: hypochloric acid water
75~86 parts of solution, 0.5~3.0 part of edible ethanol, 0.5~2.5 part of moisturizer, 0.5~3.0 part of surfactant, sweetener
2.0~3.0 parts, 1~5 part of pulullan polysaccharide, 0.1~0.5 part of edible pigment and 6~10 parts of water.
2. the mouthwash according to claim 1 containing acid fungicide, which is characterized in that further include the system of following parts by weight meter
Standby raw material: 0.05~0.15 part of sodium fluoride.
3. the mouthwash according to claim 1 containing acid fungicide, which is characterized in that further include the system of following parts by weight meter
Standby raw material: 0.5~1.0 part of edible essence.
4. the mouthwash according to claim 1 containing acid fungicide, which is characterized in that the moisturizer is glycerol.
5. the mouthwash according to claim 1 containing acid fungicide, which is characterized in that the surfactant is tween-
20。
6. the mouthwash according to claim 1 containing acid fungicide, which is characterized in that the sweetener is xylitol.
7. the mouthwash according to claim 1 containing acid fungicide, which is characterized in that the edible pigment is cape jasmine yellow
Element.
8. the mouthwash according to claim 1 containing acid fungicide, which is characterized in that the hypochloric acid water solution is slightly sour
Property hypochlorous acid electrolysis water, effective chlorine density be 40~200mg/L, pH value be 4.5~6.5, Yangization Hai original electricity Wei≤600mV.
9. a kind of preparation method of the mouthwash containing acid fungicide any according to claim 1~8, which is characterized in that
The following steps are included:
S1, moisturizer, surfactant and the sweetener that formula ratio is added into the ethyl alcohol of formula ratio, stir evenly, are made molten
Liquid A；
S2, the pulullan polysaccharide and edible pigment that formula ratio is added into the water of formula ratio, stir evenly, obtained solution B；
S3, the hypochloric acid water solution of formula ratio is mixed with solution A, solution B, is stirred evenly, gargling containing acid fungicide is made
Saliva.
10. the preparation method of the mouthwash according to claim 8 containing acid fungicide, which is characterized in that the step S1
In further include that 0.05~0.15 part of sodium fluoride in parts by weight and 0.5~1.0 part of edible essence is added.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN110123834A (en) * | 2019-05-08 | 2019-08-16 | 山东消博士消毒科技股份有限公司 | A kind of hypochlorous acid thimerosal and preparation method thereof |
| CN112603928A (en) * | 2020-12-15 | 2021-04-06 | 上海安法生物科技有限公司 | Disinfectant and detergent co-production method and disinfectant |
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| CN106798659A (en) * | 2017-03-13 | 2017-06-06 | 广州欧诺洁个人护理用品有限公司 | A kind of tooth whitening products without hydrogen peroxide |
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| CN108066166A (en) * | 2018-02-10 | 2018-05-25 | 广州市九科精细化工有限公司 | Remove acid mouthwash of calculus dentalis and preparation method thereof |
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| CN112603928A (en) * | 2020-12-15 | 2021-04-06 | 上海安法生物科技有限公司 | Disinfectant and detergent co-production method and disinfectant |
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