CN110123834A - A kind of hypochlorous acid thimerosal and preparation method thereof - Google Patents
A kind of hypochlorous acid thimerosal and preparation method thereof Download PDFInfo
- Publication number
- CN110123834A CN110123834A CN201910400263.4A CN201910400263A CN110123834A CN 110123834 A CN110123834 A CN 110123834A CN 201910400263 A CN201910400263 A CN 201910400263A CN 110123834 A CN110123834 A CN 110123834A
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- Prior art keywords
- hypochlorous acid
- parts
- thimerosal
- acid thimerosal
- stabilizer
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/20—Elemental chlorine; Inorganic compounds releasing chlorine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/02—Local antiseptics
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- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Dermatology (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Inorganic Chemistry (AREA)
- Communicable Diseases (AREA)
Abstract
The present invention relates to a kind of hypochlorous acid thimerosal and preparation method thereof, hypochlorous acid thimerosal includes following each component according to parts by weight: 70-95 parts of hypochlorous acid；1-15 parts of stabilizer；0.1-16 parts of moisturizer；1-5 parts of dispersing agent；0.5-1 parts of chelating agent；Preparation method is that hypochlorous acid, stabilizer, moisturizer, dispersing agent, chelating are added in reactor respectively, is built into a kind of recipe ingredient to reactor every time and stirs 10-20 minute, final acquisition hypochlorous acid thimerosal；The hypochlorous acid thimerosal that the technical program provides not only has the function of sterilization, disinfection, and sterilizes fastly, and nontoxic non-stimulated, stability is good, long shelf-life, natural environmental-protective, moreover it is possible to which opponent has the function of preserving moisture and protecting skin, and product system is stablized, and shelf-life durations are long.
Description
Technical field
The present invention relates to thimerosal technical field more particularly to a kind of hypochlorous acid thimerosal used for hand and its systems
Preparation Method.
Background technique
In daily activities, hand constantly contacts various things to people.And in these things, mostly containing a large amount of micro- life
Object, wherein being no lack of containing there are many pathogenic bacteria.Simultaneously with the continuous development of market economy, the social interaction of people also increasingly increases
It is more.Many pathogeny bacterium can be infected by the contact of hand.
Washing-free antibacterial hand sanitizer is a kind of novel sterile products, such product is because of its easy to use, antibacterial spy such as effectively
The deep favor by vast consumption of point, sales volume is very big always in recent years.The main component of non-water hand cleanser include sterilizability ingredient and
Volatile component, is usually added into some low-boiling alcohols solvents, and principle is that the antibacterial activities factor such as " alcohols " can be effectively
The cell wall of bacterium is destroyed, to make bacterial death, and there is bacteriolysis.But there is very in use for alcohol disinfectant
More problems.First, there is a minority can be to alcohol intolerance；Second, alcohol disinfectant is long-term or high-frequency uses, and is easy to cause
There is drying, itch and red and swollen situation in hand；Third, ethyl alcohol of the alcohol disinfectant due to using high concentration, evaporation rate is fast,
It there is a problem that waste and usage amount are larger when use；4th, the alcohol disinfectant of high concentration, alcohol smell is larger, stimulation
Human body, use feeling are poor.
Hypochlorous acid is a kind of from killing by the generation of myeloperoxidase enzymatic moment in human immune system's sterilization process
Bacteria factor (molecule) is just run so far in immune system from that time for mammal occur, and the substance itself does not have poison
Property, do not have cytotoxicity yet, water noresidue is reduced into after effect.Belong to high-effective disinfecting scope, it being capable of moment dissipation bacterial disease
Malicious brood body, but hypochlorous acid thimerosal stability on the market is poor and bigger by such environmental effects, the holding time is short.
Summary of the invention
In view of the foregoing deficiencies of prior art, the purpose of the present invention is to provide a kind of hypochlorous acid thimerosal and its systems
Preparation Method.
The technical solution adopted by the present invention to solve the technical problems is:
A kind of hypochlorous acid thimerosal, which is characterized in that including following each component according to parts by weight:
70-95 parts of hypochlorous acid；
1-15 parts of stabilizer；
0.1-16 parts of moisturizer；
1-5 parts of dispersing agent；
0.5-1 parts of chelating agent.
The mixing match content of the hypochlorous acid thimerosal and water is that the hypochlorous acid thimerosal in every kilogram of water is 95-105
Milligram.
The pH value of the hypochlorous acid thimerosal is between 4.5-6.5.
The moisturizer includes one of collagen, hyaluronic acid, ceramide, propylene glycol, Vitamin C or several
Kind.
The stabilizer is the Dequest6004 in Dequest brand Dequest6000 series, Gattefoss é company
It providesOne or both of.
The dispersing agent is hexylene glycol.
The chelating agent is one or more of gluconic acid, tartaric acid, ethylenediamine tetra-acetic acid.
A kind of preparation method of hypochlorous acid thimerosal, it is characterised in that: respectively by hypochlorous acid, stabilizer, moisturizer, dispersion
Agent, chelating agent are added in reactor, are built into a kind of recipe ingredient to reactor every time and are stirred 10-20 minutes, finally obtain
Obtain hypochlorous acid thimerosal.
In conclusion the invention has the following advantages: the hypochlorous acid thimerosal that the technical program provides not only has
Sterilization, the effect sterilized, and sterilize fastly, nontoxic non-stimulated, stability is good, long shelf-life, natural environmental-protective, moreover it is possible to opponent's tool
There is preserving moisture and protecting skin, product system is stablized, and shelf-life durations are long.
Specific embodiment
Embodiments of the present invention are illustrated by particular specific embodiment below, those skilled in the art can be by this explanation
Content disclosed by book is understood other advantages and efficacy of the present invention easily.
The present invention provides a kind of hypochlorous acid thimerosals, which is characterized in that including following each component according to parts by weight:
80 parts of hypochlorous acid；
What Gattefoss é company provided8 parts；
4 parts of Dequest6004 in Dequest brand Dequest6000 series；
8 parts of hyaluronic acid；
3 parts of propylene glycol；
0.5 part of Vitamin C；
3 parts of hexylene glycol；
1 part of gluconic acid.
The preparation method of above-mentioned hypochlorous acid thimerosal a kind of the following steps are included:
Hypochlorous acid is added in reaction vessel, then propylene glycol is added in reactor by turn on agitator, stirring is equal
It is even, mixing time 10 minutes；
It willIt is added in reactor, mixing time 10 minutes；
Dequest6004 is added in reactor, mixing time 10 minutes；
Hyaluronic acid is added in reaction vessel, mixing time 10 minutes；
Vitamin C is added in reaction vessel, mixing time 20 minutes；
Hexylene glycol, gluconic acid are added in reactor, mixing time 10 minutes, obtain and sterilized for the hypochlorous acid of hand
Liquid.
The mixing match content of above-mentioned hypochlorous acid thimerosal and water is that the hypochlorous acid thimerosal in every kilogram of water is 100 millis
Gram.
The pH value of above-mentioned hypochlorous acid thimerosal is between 5.6.
The above description is only a preferred embodiment of the present invention, as long as achieving the object of the present invention skill with essentially identical means
Art scheme, belongs within protection scope of the present invention.
Claims (8)
1. a kind of hypochlorous acid thimerosal, which is characterized in that including following each component according to parts by weight:
70-95 parts of hypochlorous acid；
1-15 parts of stabilizer；
0.1-16 parts of moisturizer；
1-5 parts of dispersing agent；
0.5-1 parts of chelating agent.
2. hypochlorous acid thimerosal according to claim 1, it is characterised in that: the mixing of the hypochlorous acid thimerosal and water is matched
It is hypochlorous acid thimerosal in every kilogram of water than content is 95-105 milligrams.
3. hypochlorous acid thimerosal according to claim 1, it is characterised in that: the pH value of the hypochlorous acid thimerosal is in 4.5-
Between 6.5.
4. hypochlorous acid thimerosal according to claim 1, it is characterised in that: the moisturizer includes collagen, transparent
One or more of matter acid, ceramide, propylene glycol, Vitamin C.
5. hypochlorous acid thimerosal according to claim 1, it is characterised in that: the stabilizer is Dequest brand
Dequest6004, Gattefoss é company in Dequest6000 series are providedOne of or two
Kind.
6. hypochlorous acid thimerosal according to claim 1, it is characterised in that: the dispersing agent is hexylene glycol.
7. hypochlorous acid thimerosal according to claim 1, it is characterised in that: the chelating agent be gluconic acid, tartaric acid,
One or more of ethylenediamine tetra-acetic acid.
8. a kind of preparation method of hypochlorous acid thimerosal, it is characterised in that: respectively by hypochlorous acid, stabilizer, moisturizer, dispersion
Agent, chelating agent are added in reactor, are built into a kind of recipe ingredient to reactor every time and are stirred 10-20 minutes, finally obtain
Obtain hypochlorous acid thimerosal.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910400263.4A CN110123834A (en) | 2019-05-08 | 2019-05-08 | A kind of hypochlorous acid thimerosal and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201910400263.4A CN110123834A (en) | 2019-05-08 | 2019-05-08 | A kind of hypochlorous acid thimerosal and preparation method thereof |
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111150778A (en) * | 2020-02-26 | 2020-05-15 | 广州市白云区天芳化妆品厂 | A sterilizing disinfectant with high safety and high efficiency for oral mucosa, skin and general articles, and its preparation method |
| CN111358731A (en) * | 2020-03-19 | 2020-07-03 | 上海国兴医疗器械有限公司 | Novel washing-free disinfectant and use method thereof |
| CN111972432A (en) * | 2020-09-17 | 2020-11-24 | 武汉市格勒特新材料有限公司 | Sodium hyaluronate/hypochlorous acid mixed disinfectant and preparation method thereof |
| CN112042667A (en) * | 2020-08-21 | 2020-12-08 | 山东知能环保科技有限公司 | Stable hypochlorous acid disinfectant and preparation method thereof |
| CN112336641A (en) * | 2020-11-24 | 2021-02-09 | 山东消博士消毒科技股份有限公司 | Hypochlorous acid hand-washing-free disinfectant and preparation method thereof |
| CN113694082A (en) * | 2020-05-21 | 2021-11-26 | 四川净入环境工程有限公司 | Hypochlorous acid disinfectant and preparation method thereof |
| CN113940946A (en) * | 2020-07-17 | 2022-01-18 | 广州大明联合橡胶制品有限公司 | Aqueous solution and preparation method and application thereof |
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111150778A (en) * | 2020-02-26 | 2020-05-15 | 广州市白云区天芳化妆品厂 | A sterilizing disinfectant with high safety and high efficiency for oral mucosa, skin and general articles, and its preparation method |
| CN111358731A (en) * | 2020-03-19 | 2020-07-03 | 上海国兴医疗器械有限公司 | Novel washing-free disinfectant and use method thereof |
| CN113694082A (en) * | 2020-05-21 | 2021-11-26 | 四川净入环境工程有限公司 | Hypochlorous acid disinfectant and preparation method thereof |
| CN113940946A (en) * | 2020-07-17 | 2022-01-18 | 广州大明联合橡胶制品有限公司 | Aqueous solution and preparation method and application thereof |
| CN112042667A (en) * | 2020-08-21 | 2020-12-08 | 山东知能环保科技有限公司 | Stable hypochlorous acid disinfectant and preparation method thereof |
| CN111972432A (en) * | 2020-09-17 | 2020-11-24 | 武汉市格勒特新材料有限公司 | Sodium hyaluronate/hypochlorous acid mixed disinfectant and preparation method thereof |
| CN112336641A (en) * | 2020-11-24 | 2021-02-09 | 山东消博士消毒科技股份有限公司 | Hypochlorous acid hand-washing-free disinfectant and preparation method thereof |
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Application publication date: 20190816 |