CN108849971A - A kind of preparation and its application method using acidulous hypochlorous acid's type thimerosal - Google Patents
A kind of preparation and its application method using acidulous hypochlorous acid's type thimerosal Download PDFInfo
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- CN108849971A CN108849971A CN201810808968.5A CN201810808968A CN108849971A CN 108849971 A CN108849971 A CN 108849971A CN 201810808968 A CN201810808968 A CN 201810808968A CN 108849971 A CN108849971 A CN 108849971A
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- hypochlorous acid
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N59/00—Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/20—Elemental chlorine; Inorganic compounds releasing chlorine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/20—Halogens; Compounds thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/10—Washing or bathing preparations
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- Pest Control & Pesticides (AREA)
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Abstract
The invention belongs to field of medical technology, and in particular to a kind of preparation and its application method using acidulous hypochlorous acid's type thimerosal.The preparation method using acidulous hypochlorous acid's type thimerosal is, prepares the uniform continuous automatic generator of hypochlorite using a kind of, by automatically controlling, not only safety but also has been capable of the quality of sterilized water needed for strict control, but also can largely prepare；Due to the neutral small molecule that hypochlorous acid molecule is strong oxidizing property, so being extremely easy to contact and enter the inside of bacterium or virus, destroy the inside gene of bacterium or virus and the biological enzyme of living necessities, it causes it to lose its activity, various bacterial micro-organisms can be killed, there is the antivirus action of strength, can be killed to Bacillus；The weak acid water is highly-safe since the pH value of pH value and human skin is close, can be directly used on skin, and non-stimulated to skin, and will not aggravate the pain sense when for wound, and the burden of patient is reduced in the treatment of burn.
Description
Technical field
The invention belongs to field of medical technology, and in particular to a kind of preparation using acidulous hypochlorous acid's type thimerosal and
Its application method.
Background technique
In 1079233358 A of patent No. CN, a kind of thimerosal, including dichloro cresols, potassium hydroxide, penta 2 are disclosed
Aldehyde, isopropanol, potassium iodide, iodine, neopelex and purified water, the invention by iodine molecule activation for effectively sterilization because
Son, although avoiding the waste of iodine in this way, the use of a large amount of iodines can generate counter productive to human body.
In 104351276 A of patent No. CN, a kind of thimerosal is disclosed, is mixed by the ingredient of following weight percents
Composition：0.4%~0.6% bamboo vinegar powder 3% of kefir milk element；Calgon 4%；N-Propyl Bromide 4%；Olive oil 4%；Trichlorine
New 0.2%；Polyoxyethylene alkylphenyl ether 2%；Glyceride citrate 0.35%；Aloe powder 0.25%；Chlorhexidine hydrochloride 15%；Alkane
Base Glycinates 0.6%；Deionized water surplus；Though the invention formulation cost is low but bactericidal effect is to be improved.
Hypochlorous acid can make to provide the ferment group of the life energy for bacterium, and cell membrane and nucleus acidification make it lose work
Property；Hypochlorous acid can be the protein, ferment and its RNA, DNA acidification of inside of virus surface, cause it to lose its activity；Due to it
Sterilizing mechanisms are different from other antibiotic drugs, and hypochlorous acid will not make bacterium and virus develop drug resistance.So if can be reasonable
Use javelle water, the production space in thimerosal field will be widened.
Summary of the invention
In order to achieve the purpose that in background technique, the present invention proposes a kind of matching using acidulous hypochlorous acid's type thimerosal
System and its application method, the weak acid hypochloric acid water are a kind of sterilized waters that pH value is 5.0-6.5, can kill the micro- life of various bacteriums
Object has the antivirus action of strength, can kill to Bacillus；PH value of the weak acid water due to pH value and human skin
It is close, it is highly-safe, it can be directly used on skin, and non-stimulated to skin, will not aggravate the pain sense when for wound,
The burden of patient is reduced in the treatment of burn.This acidulous hypochlorous acid is by deionized water, hypochlorous acid, micro sodium chloride group
At.The weak acid hypochloric acid water can be used for directly cleaning affected part, while playing the role of cooling and sterilizing；Trouble can also directly be rinsed
Place, plays the role of cleaning and disinfection, and also have facilitation to the healing of wound；Spraying device, which can be added, simultaneously makes
With, carry out disinfection to environment, improve environment in humidity, cambium involves bring pain when alleviating burn wound healing
Sense.The slightly acidic water will not generate drug resistance to bacterium and virus, free from environmental pollution, can deodorization, fresh air.
The present invention realizes by the following technical solutions：
A kind of preparation and its application method using acidulous hypochlorous acid's type thimerosal, which is characterized in that the utilization
The preparation method of acidulous hypochlorous acid's type thimerosal is to prepare the uniform continuous automatic generator of hypochlorite using a kind of,
By automatically controlling, not only safety but also the quality of sterilized water needed for strict control had been capable of it, but also can largely prepare.
Further, the effective chlorine density 50mg/L.
Further, described is to adjust pH value by using hydrochloric acid using acidulous hypochlorous acid's type thimerosal, makes its PH
Value reaches 5.0-6.5, and due to close with the pH value of human skin, safety is considerably improved.
Further, the product is a kind of slightly acidic water solution, and appearance colorless is transparent, and ingredient is deionized water, secondary
Chloric acid, micro sodium chloride, belong to a kind of chlorine-containing disinfectant.
Further, the application method is that weak acid hypochloric acid water can be used for directly cleaning affected part, at the same have it is cooling and
The effect of disinfection；Affected part can also be directly rinsed, cleaning and disinfection are played the role of, while spraying device use can be added,
It carries out disinfection to environment, improves the humidity in environment, cambium involves bring feeling of pain when alleviating burn wound healing.
Beneficial to benefit
1, thimerosal prepared by the present invention, weak acid hypochloric acid water are a kind of sterilized waters that pH value is 5.0-6.5, can be killed each
Kind bacterial micro-organism, has strong antivirus action, can kill to Bacillus, and due to its pH value and human skin
PH value it is close, it is highly-safe, can be directly used on skin, it is non-stimulated to skin, will not aggravate the pain when for wound
Sense reduces the burden of patient in the treatment of burn；
2, the operation principle of the present invention is that hypochlorous acid can make to provide the ferment group of the life energy for bacterium, cell membrane and thin
Karyon acidification, causes it to lose its activity；Hypochlorous acid can be the protein, ferment and its RNA, DNA acidification of inside of virus surface,
It causes it to lose its activity；Since its sterilizing mechanisms is different from other antibiotic drugs, hypochlorous acid will not make bacterium and virus generate anti-medicine
Property.
3, the product that uses of the present invention is a kind of slightly acidic water solution, and appearance colorless is transparent, and ingredient is deionized water, secondary
Chloric acid, micro sodium chloride, belong to a kind of chlorine-containing disinfectant, due to the neutral small molecule that hypochlorous acid molecule is strong oxidizing property, so
It is extremely easy to contact and enter the inside of bacterium or virus, destroys the inside gene of bacterium or virus and the life of living necessities
Object enzyme, causes it to lose its activity.
4, a kind of acidulous hypochlorous acid can be directly used on skin, and stingless to skin since its is highly-safe
Swash, will not aggravate the pain sense when for wound, and also have facilitation to the healing of wound；It can subtract in the treatment of burn
The burden of few patient.
Specific embodiment
In order to keep the purpose of the present invention, technical scheme and beneficial effects clearer, below in conjunction with experimental data, to this
The preferred embodiment of invention is described in detail, to facilitate the technical staff to understand.
Embodiment 1
It is a kind of to be included the following steps using the preparation and its application method of acidulous hypochlorous acid's type thimerosal：
58 years old, male was poured down by boiled water from head, caused above the waist 45% scalding area, and scald depth has erythema, bubble
And erosion, there is strong feeling of pain, is accredited as II degree scald.Therapeutic scheme is：Fully use acidulous hypochlorous acid (PH
Value 5.5, effective chlorine density 50ml/L), carry out local cleaning, cooling and disinfection；After 3 days, 10 liters of faintly acid hypochlorous acid are used
Water is slowly rinsed from head, and whole body is made fully to be cleaned and be sterilized；Carry out such rinse three-times-weekly later；10 after wound
It when, due to patient say injury it is tight pain, just use acidulous hypochlorous acid's atomising device, persistently make patient in atomization space
In.
Experimental analysis：
1, bactericidal effect
The bactericidal effect of acidulous hypochlorous acid's type thimerosal is as shown in the table：
2, product of the present invention is to results of animal：
Intact skin stimulate the reaction scoring of rabbit
Note：Integral mean value is the integral of the stimulate the reaction of average every animal；(most to intact skin stimulation of rabbit
It is high) integral mean value is 0, belongs to nonirritant.
Chmice acute Oral toxicity test result
Note：The equal > 5000mg/kg of the LD50 of male and female mouse, the true nontoxic grade in border.
Rabbit eyes stimulate the reaction integral
Note：Rabbits with Acute Eye irritation average score cornea or iris=0 point are 3.Conjunctival congestion or oedema=0 point are
3, belong to nonirritant.Average score refer to for 24 hours, 48h, 72h scoring the sum of divided by time hop counts 3.
3, slightly acidic water is clinically to the therapeutic effect of burn
From 1 clinical practice of embodiment using evaluation of patient in terms of, the use of acidulous hypochlorous acid can be very good treatment scald
Wound is made patient almost in a kind of environment of sterilizing, is reduced the machine of infection using the method directly rinsed with room spray
Meeting, while the tight bring pain in wound is also mitigated, wound is not adhered, and healed surface is floated very much
It is bright.
Finally, it is stated that preferred embodiment above is only used to illustrate the technical scheme of the present invention rather than limits, although logical
It crosses above preferred embodiment the present invention is described in detail, however, those skilled in the art should understand that, can be
Various changes are made to it in form and in details, without departing from defined by claims of the present invention.
Claims (5)
1. a kind of preparation and its application method using acidulous hypochlorous acid's type thimerosal, which is characterized in that described using weak
The preparation method of acid hypochlorous acid water type thimerosal is to prepare the uniform continuous automatic generator of hypochlorite using a kind of, lead to
Automatic control is crossed, not only safety but also has been capable of the quality of sterilized water needed for strict control, but also can largely prepare.
2. a kind of preparation and its application method using acidulous hypochlorous acid's type thimerosal according to claim 1,
It is characterized in that, the effective chlorine density 50mg/L.
3. a kind of preparation and its application method using acidulous hypochlorous acid's type thimerosal according to claim 1,
It is characterized in that, described is to adjust pH value by using hydrochloric acid using acidulous hypochlorous acid's type thimerosal, reaches its pH value
5.0-6.5, due to close with the pH value of human skin, safety is considerably improved.
4. a kind of preparation and its application method using acidulous hypochlorous acid's type thimerosal according to claim 1,
It is characterized in that, the product is a kind of slightly acidic water solution, and appearance colorless is transparent, and ingredient is deionized water, hypochlorous acid, micro-
Sodium chloride is measured, a kind of chlorine-containing disinfectant is belonged to.
5. a kind of preparation and its application method using acidulous hypochlorous acid's type thimerosal according to claim 1,
It is characterized in that, the application method is that weak acid hypochloric acid water can be used for directly cleaning affected part, while have cooling and disinfection
Effect；Affected part can also be directly rinsed, cleaning and disinfection are played the role of, while spraying device use can be added, to environment
It carries out disinfection, improves the humidity in environment, cambium involves bring feeling of pain when alleviating burn wound healing.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201810808968.5A CN108849971A (en) | 2018-07-15 | 2018-07-15 | A kind of preparation and its application method using acidulous hypochlorous acid's type thimerosal |
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| CN201810808968.5A CN108849971A (en) | 2018-07-15 | 2018-07-15 | A kind of preparation and its application method using acidulous hypochlorous acid's type thimerosal |
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Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110123834A (en) * | 2019-05-08 | 2019-08-16 | 山东消博士消毒科技股份有限公司 | A kind of hypochlorous acid thimerosal and preparation method thereof |
| CN110885127A (en) * | 2019-09-23 | 2020-03-17 | 昆山阳澄蓝谷环境研究所有限公司 | Wastewater treatment method using molecular weakly acidic HOCl water |
| CN111150778A (en) * | 2020-02-26 | 2020-05-15 | 广州市白云区天芳化妆品厂 | A sterilizing disinfectant with high safety and high efficiency for oral mucosa, skin and general articles, and its preparation method |
| CN111481723A (en) * | 2020-04-17 | 2020-08-04 | 重庆有艾生物科技有限公司 | Integrated technology and method for dynamically disinfecting air in gathering place by using weak-acid hypochlorous acid disinfectant |
| CN111972432A (en) * | 2020-09-17 | 2020-11-24 | 武汉市格勒特新材料有限公司 | Sodium hyaluronate/hypochlorous acid mixed disinfectant and preparation method thereof |
| CN113244264A (en) * | 2021-06-07 | 2021-08-13 | 青岛威巴克生物技术有限公司 | Novel protective agent for promoting healing of ulcer surface |
| CN115317649A (en) * | 2022-08-09 | 2022-11-11 | 中科产业服务中心(广州)有限公司 | Portable virus protection method and device |
| CN115770254A (en) * | 2022-12-15 | 2023-03-10 | 山东舒达生物科技有限公司 | Preparation method of burn cleaning solution |
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Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110123834A (en) * | 2019-05-08 | 2019-08-16 | 山东消博士消毒科技股份有限公司 | A kind of hypochlorous acid thimerosal and preparation method thereof |
| CN110885127A (en) * | 2019-09-23 | 2020-03-17 | 昆山阳澄蓝谷环境研究所有限公司 | Wastewater treatment method using molecular weakly acidic HOCl water |
| CN111150778A (en) * | 2020-02-26 | 2020-05-15 | 广州市白云区天芳化妆品厂 | A sterilizing disinfectant with high safety and high efficiency for oral mucosa, skin and general articles, and its preparation method |
| CN111481723A (en) * | 2020-04-17 | 2020-08-04 | 重庆有艾生物科技有限公司 | Integrated technology and method for dynamically disinfecting air in gathering place by using weak-acid hypochlorous acid disinfectant |
| CN111972432A (en) * | 2020-09-17 | 2020-11-24 | 武汉市格勒特新材料有限公司 | Sodium hyaluronate/hypochlorous acid mixed disinfectant and preparation method thereof |
| CN113244264A (en) * | 2021-06-07 | 2021-08-13 | 青岛威巴克生物技术有限公司 | Novel protective agent for promoting healing of ulcer surface |
| CN115317649A (en) * | 2022-08-09 | 2022-11-11 | 中科产业服务中心(广州)有限公司 | Portable virus protection method and device |
| CN115770254A (en) * | 2022-12-15 | 2023-03-10 | 山东舒达生物科技有限公司 | Preparation method of burn cleaning solution |
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