CN113499272A - Chlorhexidine gluconate-containing mouthwash and preparation method thereof - Google Patents
Chlorhexidine gluconate-containing mouthwash and preparation method thereof Download PDFInfo
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- CN113499272A CN113499272A CN202111034672.0A CN202111034672A CN113499272A CN 113499272 A CN113499272 A CN 113499272A CN 202111034672 A CN202111034672 A CN 202111034672A CN 113499272 A CN113499272 A CN 113499272A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/43—Guanidines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/89—Polysiloxanes
- A61K8/896—Polysiloxanes containing atoms other than silicon, carbon, oxygen and hydrogen, e.g. dimethicone copolyol phosphate
- A61K8/898—Polysiloxanes containing atoms other than silicon, carbon, oxygen and hydrogen, e.g. dimethicone copolyol phosphate containing nitrogen, e.g. amodimethicone, trimethyl silyl amodimethicone or dimethicone propyl PG-betaine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
- A61K8/987—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of species other than mammals or birds
- A61K8/988—Honey; Royal jelly, Propolis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
Abstract
The invention discloses a mouthwash containing chlorhexidine gluconate and a preparation method thereof, the mouthwash comprises chlorhexidine gluconate solution (0.1-0.3% by mass percent, the same below), natural propolis extract (0.04-2.0%), cocamidopropyl betaine (0.05-2.0%), hydrogenated castor oil PEG-40 (0.02-2.4%), food-grade spearmint essence (0.01-0.2%), xylitol (0.02-0.4%), mint extract (0.05-2.0%) and polysiloxane quaternary ammonium salt (0.01-0.4%) bacteriostatic agent, and deionized water is used as a solvent, alcohol (ethanol) is not added absolutely, so that violation and danger of drunk driving and drunk driving of a user are avoided. The oral liquid is characterized in that chlorhexidine gluconate and natural propolis extract components are innovatively added in the materials, and the chlorhexidine gluconate and the natural propolis extract components can provide the mouthwash with the auxiliary function of relieving the oral problems of gingivitis, oral ulcer and pharyngitis; the mouthwash is endowed with the functions of keeping breath fresh and inhibiting oral peculiar smell by being matched with the spearmint essence, the xylitol sweetener, the mint extract cooling agent and the polysiloxane quaternary ammonium salt bacteriostatic agent.
Description
Technical Field
The invention belongs to the technical field of daily chemical industry, and relates to effective utilization of functional raw materials for maintaining the comfort and health of human bodies, wherein target products have obvious effects on cleaning oral cavities, refreshing breath and the like.
Technical Field
Tooth brushing is a daily hygiene habit of modern residents, and is also an effective method for keeping the oral cavity clean and relieving halitosis and gum related problems. However, except for preschool children and people who are in leisure homes (such as free employees or retirees), more people read books, work and play outside, the rhythm of life is fast, and the people are inconvenient to carry the tooth brush toothpaste and clean the oral cavity in time; however, sometimes people want to remove the discomfort of breath in the mouth improvingly. Thus, a number of commercial mouthwashes (or sprays, the same below) have been available in foreign markets over 20 years ago to meet the aforementioned diverse needs of the consumer population.
The standards of the light industry of the people's republic of China QB/T2945 + 2012 for oral cleaning care solution classify various oral cleaning and care liquid products such as mouthwash, oral spray and the like suitable for oral application as oral cleaning care solution, the requirements of the used raw materials should meet the GB 22115 + 2008 specification for raw materials for toothpaste, and the sensory physicochemical indexes, the sanitary indexes, the package appearance and other technical requirements are specified in detail. Under the normative guidance of the standards, a plurality of similar products are produced in China for the people to choose and carry about.
By searching and looking up related technical documents (including patent data), the main functional raw materials added into the mouthwash in the current market are lysozyme, licoflavone, agastache rugosus, lonicera confusa, radix zanthoxyli, pseudo-ginseng, mint and other traditional Chinese medicine combined extracts. The producers declare that the introduction of the raw materials can supplement the bacteriolysis capability in saliva, promote the repair of damaged tissues of the oral cavity, balance the flora of the oral cavity and restore the health state of the oral cavity; cleaning tartar, reducing oral bacteria and protecting oral cavity and gum health; has the functions of diminishing inflammation, inhibiting bacteria, effectively removing food residues and soft dirt remained in the oral cavity and simultaneously quickly relieving gum pain.
The invention relates to a chlorhexidine gluconate-containing mouthwash and a preparation method thereof, which completely comply with the technical requirements of QB/T2945-. In order to provide the remarkable effects of cleaning the oral cavity and refreshing and freshening breath, chlorhexidine gluconate solution with auxiliary curative effect on gingivitis, oral ulcer and pharyngitis and natural propolis active extract are particularly added into the raw materials of the formula, so that the mouthwash (or spray) capable of keeping the oral cavity clean, improving the peculiar smell of the oral cavity and refreshing and freshening breath is obtained.
Disclosure of Invention
The invention provides a chlorhexidine gluconate-containing mouthwash and a preparation method thereof, aiming at solving the problem of 'breath halitosis' which is particularly common and unpleasant for citizens at present, and the chlorhexidine gluconate solution and the active extract of natural propolis are added, so that after a consumer uses the mouthwash (sprayed or gargled), the breath freshness can be effectively kept for more than 1 hour.
The present invention adopts the following solutions to solve the above technical problems, including but not limited to the following process measures. Based on years of toothpaste production experience, the formula design technical key points of the mouthwash are determined to be as follows from the comprehensive requirements of the public on the impromptu fresh breath: provides auxiliary functionality for relieving oral problems of gingivitis, oral ulcer and pharyngitis, and gives the sweet fragrance of refreshing the lung, retains the slightly sweet taste of the tongue, keeps fresh and comfortable cool feeling, and ensures the sustained and effective antibacterial effect. Chlorhexidine gluconate and natural propolis are innovatively added in the aspect of materials, classic spearmint essence is selected, a xylitol sweetening agent suitable for diabetics is added, a cool taste is provided by a mint extract, and polysiloxane quaternary ammonium salt is used as a bacteriostatic agent to comprehensively control the generation of oral peculiar smell.
The invention has the following beneficial effects:
1. chlorhexidine gluconate and natural propolis components provide auxiliary functionality for relieving oral problems of gingivitis, canker sore, pharyngitis;
2. the classic food-grade spearmint type essence is adopted to endow the mouthwash with an initial refreshing smell;
3. xylitol is added as a sweetening agent, so that a user can enjoy the slightly sweet taste of the compatible tongue coating, and the xylitol is also suitable for diabetes patients;
4. the mint extract is natural, and the retained cool feeling is natural and comfortable;
5. the polysiloxane quaternary ammonium salt bactericide is a liquid preparation which is easy to dissolve in water, so that the potential danger of micromolecule bactericides such as potassium sorbate, sodium benzoate, nipagin ester and the like to human health is avoided, and the sustained and effective antibacterial effect is ensured.
Description of the drawings:
FIG. 1 is a photograph showing a lipstick type package of a push-type spray type mouth wash, and a photograph showing a conventional flip-up bottle is not shown.
The specific implementation mode is as follows:
the technical solution of the present invention is further illustrated by the following examples.
Example 1
The formulation of the mouthwash of this example (in weight%) comprises the following raw materials: chlorhexidine gluconate solution (0.28%, by mass, the same below), natural propolis extract 0.5%, cocamidopropyl betaine 1.8%, hydrogenated castor oil PEG-40 1.5%, xylitol 0.28%, peppermint extract 1.5%, silicone quaternary ammonium salt-18 0.2%, food-grade spearmint essence 0.16%, and deionized water (balance).
The preparation process comprises the following steps: (1) weighing the components according to the formula amount; (2) sequentially adding 1/2 total amount of deionized water, chlorhexidine gluconate solution, and natural propolis extract into a stirring kettle, and stirring to dissolve and disperse uniformly; then adding cocamidopropyl betaine, hydrogenated castor oil PEG-40, xylitol, mint extract and polysiloxane quaternary ammonium salt in sequence while stirring. Stirring for 30 minutes continuously, dissolving completely and uniformly, slowly adding the spearmint essence for blending, adding the rest deionized water, stirring uniformly, standing and aging for 2 hours, and simultaneously starting an ultraviolet lamp on a kettle cover for sterilization treatment. Sampling, carrying out quality detection according to QB/T2945 and 2012 'oral cavity cleaning care solution', wrapping the outlet of the emptying valve by using 180-mesh filter screen cloth to filter after the oral cavity cleaning care solution is qualified, discharging and filling.
Example 2
The formulation of the mouthwash of this example (in weight%) comprises the following raw materials: chlorhexidine gluconate solution (0.22%, by mass, the same below), natural propolis extract 1.4%, cocamidopropyl betaine 1.8%, hydrogenated castor oil PEG-40 1.5%, xylitol 0.35%, peppermint extract 1.8%, silicone quaternary ammonium salt-18 0.2%, food-grade spearmint essence 0.18%, and deionized water (balance).
The preparation process is the same as above: (1) weighing the components according to the formula amount; (2) sequentially adding 1/2 total amount of deionized water, chlorhexidine gluconate solution, and natural propolis extract into a stirring kettle, and stirring to dissolve and disperse uniformly; then adding cocamidopropyl betaine, hydrogenated castor oil PEG-40, xylitol, mint extract and polysiloxane quaternary ammonium salt in sequence while stirring. Stirring for 30 minutes continuously, dissolving completely and uniformly, slowly adding the spearmint essence for blending, adding the rest deionized water, stirring uniformly, standing and aging for 2 hours, and simultaneously starting an ultraviolet lamp on a kettle cover for sterilization treatment. Sampling, carrying out quality detection according to QB/T2945 and 2012 'oral cavity cleaning care solution', wrapping the outlet of the emptying valve by using 180-mesh filter screen cloth to filter after the oral cavity cleaning care solution is qualified, discharging and filling.
Comparative example
The comparative example is prepared according to example 1 in the Chinese invention patent 2019100548860 'Compound traditional Chinese medicine mouthwash and the preparation method thereof', and comprises the following raw materials in parts by weight: 12% of traditional Chinese medicine composition extract, 0.01% of sucralose, 0.02% of malic acid, 2% of glycerol, 0.01% of methyl paraben, 0.5% of menthol and the balance of water, wherein the raw material medicines of the traditional Chinese medicine extract comprise: 20 parts of wrinkled gianthyssop herb, 12 parts of lonicera confusa and 2 parts of pseudo-ginseng. The preparation method comprises the following steps: weighing herba Agastaches, flos Lonicerae and Notoginseng radix according to a certain proportion, mixing to obtain a Chinese medicinal mixture, adding 15 times of water into the Chinese medicinal mixture, boiling and extracting for 2 times, 2 hr for the first time, 1.5 hr for the second time, mixing the filtrates obtained by 2 times of extraction, concentrating under reduced pressure to obtain a concentrated solution (the specific gravity at 80 deg.C is 1.05), adding 95% edible alcohol into the concentrated solution to make the alcohol content in the solution 60%, stirring, standing for 24 hr, filtering to remove precipitate to obtain an alcohol precipitation filtrate, and concentrating the alcohol precipitation filtrate to obtain a Chinese medicinal extract (the specific gravity at 80 deg.C is 1.07); and then fully mixing the traditional Chinese medicine composition extract, sucralose, malic acid, glycerol, methyl paraben, menthol and water, sampling for detection according to QB/T2945-.
The results of the quality tests of the products of the two examples and comparative examples are summarized and compared in the following table 1.
TABLE 1 comparison of sample test data for examples and comparative examples
Comparing the technical data of the 2 embodiments and the comparative example, it can be seen that the mouth wash containing chlorhexidine gluconate obtained by the technical scheme of the invention has the effects of maintaining the fresh feeling in the oral cavity, assisting in relieving gingivitis, canker sore and pharyngitis discomfort and obviously reducing the odor of the breath with the more popular compound traditional Chinese medicine mouth wash on the market.
Finally, it should be noted that: the above examples are only intended to illustrate the technical solution of the present invention, but not to limit it; although the present invention has been described in detail with reference to the foregoing embodiments, it will be understood by those of ordinary skill in the art that: the technical solutions described in the foregoing embodiments may still be modified, or some technical features may be equivalently replaced; such modifications and substitutions do not affect the spirit and scope of the present disclosure.
Claims (10)
1. A mouth wash containing chlorhexidine gluconate and natural propolis extract are innovatively added in materials, and cocamidopropyl betaine and hydrogenated castor oil PEG-40 are used as system stabilizers, spearmint essence, xylitol sweetening agents, mint extract cooling agents and polysiloxane quaternary ammonium salt bacteriostatic agents are used for comprehensively inhibiting the generation of oral peculiar smell.
2. The chlorhexidine gluconate-containing mouthwash according to claim 1, wherein the chlorhexidine gluconate-containing mouthwash comprises a chlorhexidine gluconate solution (0.1% to 0.3%, by weight, the same below), and the ingredient can provide the mouthwash with an auxiliary function of alleviating the problems of gingivitis, canker sores, pharyngitis and oral cavity.
3. The chlorhexidine gluconate-containing mouth wash and the preparation method thereof as claimed in claim 1, wherein the mouth wash contains natural propolis extract (0.04% -2.0%), which can relieve discomfort such as oral gingivitis, ulcer, pharyngitis, etc.
4. The chlorhexidine gluconate-containing mouthwash and the preparation method thereof according to claim 1, wherein the mouthwash comprises 0.05% to 2.0% of cocamidopropyl betaine and 0.02% to 2.4% of hydrogenated castor oil PEG-40, so that the mouthwash system is more stable.
5. The chlorhexidine gluconate-containing mouthwash and the preparation method thereof according to claim 1, wherein the mouthwash contains 0.01-0.2% of food-grade spearmint essence, which can endow the mouthwash with refreshing smell.
6. The chlorhexidine gluconate-containing mouthwash according to claim 1, wherein the chlorhexidine gluconate-containing mouthwash contains 0.02% to 0.4% of xylitol, which provides a slightly sweet and pleasant taste to the user and is also suitable for diabetics.
7. The chlorhexidine gluconate-containing mouthwash according to claim 1, wherein the mint extract is added in an amount of 0.05% to 2.0% to provide a comfortable and natural cooling feeling to the user.
8. The chlorhexidine gluconate-containing mouth wash and the preparation method thereof as claimed in claim 1, wherein 0.01% -0.4% of polysiloxane quaternary ammonium salt bacteriostatic agent is added, so as to avoid the potential danger of potassium sorbate, sodium benzoate, paraben and other micromolecular bacteriostatic agents to human health and ensure sustained and effective bacteriostatic effect.
9. The chlorhexidine gluconate-containing mouth wash and the preparation method thereof as claimed in claim 1, wherein deionized water (balance) is used as the solvent, and alcohol (ethanol) is not added absolutely, so as to avoid violation and danger hidden trouble of "drunk driving" and "drunk driving" of users.
10. The chlorhexidine gluconate-containing mouthwash according to claim 1, wherein the preparation process comprises the following steps: (1) weighing the components according to the formula amount; (2) sequentially adding 1/2 total amount of deionized water, chlorhexidine gluconate solution, and natural propolis extract into a stirring kettle, and stirring to dissolve and disperse uniformly; then adding xylitol, mint extract and polysiloxane quaternary ammonium salt in sequence while stirring. Stirring for 30 minutes continuously, dissolving completely and uniformly, slowly adding the spearmint essence for blending, adding the rest deionized water, stirring uniformly, standing and aging for 2 hours, and simultaneously starting an ultraviolet lamp on a kettle cover for sterilization treatment. Sampling, carrying out quality detection according to QB/T2945 and 2012 'oral cavity cleaning care solution', wrapping the outlet of the emptying valve by using 180-mesh filter screen cloth to filter after the oral cavity cleaning care solution is qualified, discharging and filling.
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| Application Number | Priority Date | Filing Date | Title |
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| CN202111034672.0A CN113499272A (en) | 2021-09-05 | 2021-09-05 | Chlorhexidine gluconate-containing mouthwash and preparation method thereof |
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| CN202111034672.0A CN113499272A (en) | 2021-09-05 | 2021-09-05 | Chlorhexidine gluconate-containing mouthwash and preparation method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN115463080A (en) * | 2022-10-14 | 2022-12-13 | 广州市润研基因科技有限公司 | Method for producing natural fresh mouth wash |
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2021
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| CN115463080A (en) * | 2022-10-14 | 2022-12-13 | 广州市润研基因科技有限公司 | Method for producing natural fresh mouth wash |
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