KR102502829B1 - Liquid composition for gargle containing tea tree oil and aloe vera gel - Google Patents

Abstract

Provided is a liquid composition for gargle containing tea tree oil, aloe vera gel, a propolis extract, cetylpyridinium chloride, and sage extract. The liquid composition for gargle containing the tea tree oil and aloe vera gel according to the present invention has bad breath removing and breath freshening effects.

Description

Liquid composition for gargling containing tea tree oil and aloe vera gel {LIQUID COMPOSITION FOR GARGLE CONTAINING TEA TREE OIL AND ALOE VERA GEL}

The present invention relates to a liquid composition for gargling, and more particularly, to a concentrated liquid composition for gargling containing tea tree oil, and more particularly to tea tree oil, aloe vera gel, propolis extract, and cetylpyridinium chloride And it relates to a concentrated liquid composition for gargling containing sage extract.

BACKGROUND OF THE INVENTION [0002] The oral cavity is an entrance to the digestive and respiratory organs, and is composed of mucous membranes and is an organ in which the tongue, gums, teeth, and salivary glands are arranged. When food is put into the oral cavity, the food is pulverized through mastication, saliva secreted from the salivary gland is mixed with the pulverized food, and then the mixture moves to the esophagus after being connected to the oral cavity. In the oral environment where these functions are performed, residual debris generated after ingestion of various foods may not be completely removed, and as a result, it is exposed to negative changes such as bad breath, plaque formation, tooth decay, gum disease, pigmentation, and the like.

Tooth decay refers to a phenomenon in which teeth are damaged as the inorganic matter on the surface of the tooth is eliminated by acid generated by bacteria such as mutans, and the organic matter inside the tooth, which is minimized contact with the outside by the tooth surface, is dissolved. Plaque refers to a bacterial film formed mainly on the surface of teeth as bacteria present in the oral cavity proliferate.

Bad breath is an unpleasant odor caused by the decay of food residues or the metabolism of food residues by bacteria and fungi in the mouth as food residues are present in the oral cavity. In the case of eating the same food, strong bad breath may occur due to a specific ingredient unique to the food, or the time required for the process of naturally suppressing bad breath due to secretions such as saliva in the mouth may increase, In general, sulfur-containing gases, typically hydrogen sulfide (H ₂ S), methyl mercaptan (CH ₃ SH), and dimethyl sulfide (CH ₃ SCH ₃ ), are widely known as bad breath-inducing gases.

In order to prevent or suppress the problems related to oral hygiene as described above, it is common and recommended to hygienically manage the oral environment by removing residual food and plaque in the oral cavity through brushing with a toothbrush and toothpaste. Toothpaste typically contains a surfactant and an abrasive, and is used by a toothbrush, which is a physical cleaning tool, to perform a function of removing food and other plaques remaining in the oral cavity, in particular, adhered to teeth.

In addition, toothpastes containing various active ingredients such as fluoride and calculus removers have been developed to effectively control factors that negatively affect oral hygiene. However, brushing with a toothbrush and toothpaste that is commonly available may not be sufficient to hygienically change the oral environment to a desired level depending on the shape of the toothbrush, and to overcome this problem, an interdental toothbrush, Oral hygiene management through a liquid composition for flossing and/or gargling has been proposed.

Interdental brushes and dental floss are known to be effective in removing food remnants and the like located in spaces between teeth where a toothbrush cannot reach. However, oral hygiene management through interdental brushes and dental floss is limited in that it is generally performed after brushing teeth with a toothbrush, and there are temporal and spatial limitations for using the interdental brushes and dental floss.

Oral hygiene management through the liquid composition for gargling is, after brushing teeth with a toothbrush and toothpaste, after oral care using an interdental brush and / or dental floss, the toothbrush, interdental brush and / or dental floss can not reach the debris remaining in the oral space It is widely known as an effective means to remove or remove harmful germs or components that cause tooth decay, bad breath, and other oral diseases. Gargling is generally performed by keeping the liquid composition for gargling in the oral cavity and circulating it based on the fact that the composition for gargling is a liquid composition, and a liquid composition for gargling is provided for this purpose.

The liquid composition for gargling generally contains water, ethanol, antibacterial ingredients, and other various active ingredients for improving oral hygiene, and the water content in order to stably secure the advantages of the liquid composition for gargling based on the characteristics of liquid has this high quality.

For the above-described desirable oral hygiene management, after oral care using a toothbrush, toothpaste, interdental brush, and/or floss, a gargling step is required to remove remaining food and other microscopic contaminants. The step-by-step oral hygiene management as described above is usually performed after waking up in the morning and after breakfast for general modern people, and oral hygiene management is performed after meals or as needed in daily life.

However, despite the advantages provided by oral hygiene management through gargling, due to the nature of the liquid composition for gargling having a high water content, the volume of the liquid composition for sufficiently performing the gargling step is relatively large compared to, for example, toothpaste There are problems with being large and heavy. This is a major factor that makes the portability of the liquid composition for gargling low, especially compared to the portability of a toothbrush and toothpaste. This is practically required almost every day, and in certain cases, a situation in which gargling cannot be performed may also occur as supplementation is not made.

In addition, although a generally provided liquid composition for gargling uses a gargling method in which a certain amount of the composition is used for a certain period of time, gargling according to the gargling method according to the user's oral environment may It can provide more than necessary stimulation to the oral cavity of the user, which can negatively affect the user's oral environment, and when the user's oral environment is poor, the gargling method provides sufficient oral cooling effect and prevents plaque, tooth decay and various gum diseases There are also cases where the effect of cannot be obtained.

In addition, even when the gargling step is performed using the liquid composition for gargling, the conventional liquid composition for gargling performs the function of removing various contaminants through the fluid flow formed by the liquid composition in the oral cavity, that is, by physical means. In addition, based on the function of various active ingredients included in the composition, it provides the effect of refreshing the oral cavity and improving oral health, but conventionally used essential oil, cetylpyridinium chloride, fluorine and other active ingredients having similar purposes and functions There is also a problem that the effect of improving oral health and oral health is not sufficient.

Therefore, there is a need for a liquid composition for gargling that maximizes the beneficial effects of the active ingredients contained in the liquid composition for gargling and provides improved plaque removal and tooth decay prevention effects compared to conventional liquid gargling compositions.

Furthermore, as the liquid composition for gargling as described above is provided as a concentrated liquid composition for gargling, the concentration of the active ingredient contained in the liquid composition for gargling is diluted to suit the user. The liquid composition for gargling is easily obtained by the user Based on this, there is a need for a liquid composition for gargling that can respond variably according to the oral environment of modern people, which is changed by various factors.

The present invention provides a liquid composition for gargling containing sage extract and cetylpyridinium chloride, and liquid gargling containing tea tree oil and aloe vera gel in order to solve the problems of the conventional liquid composition for gargling. Provides a composition, and furthermore, provides a liquid composition for gargling that further includes a propolis extract, in particular, sage extract, tea tree oil, and aloe vera gel in a ratio of 0.1: 1: 1 based on the weight of each component Provided is a liquid composition for gargling.

In addition, the present invention provides a liquid composition for gargling in order to solve the problems of the conventional liquid composition for gargling. More specifically, while providing a concentrated liquid composition for gargling with a drastically reduced water content, the user can mix the concentrated liquid composition for gargling with water to obtain a liquid composition for gargling, and special in the mixing Provided is a concentrated liquid composition for gargling that is quickly and easily mixed with water so that no equipment or means are required.

The inventors of the present invention found that the liquid composition for gargling containing tea tree oil and aloe vera gel according to the present invention has an effect of removing bad breath and refreshing the mouth, and in particular, the tea tree oil and the aloe vera gel It was found that the liquid composition for gargling, which was included in a ratio of 1:1 based on the weight of each component, had an excellent effect on removing bad breath.

The inventors of the present invention found that the liquid composition for gargling containing tea tree oil and aloe vera gel according to the present invention has the effect of removing plaque and inhibiting tooth decay, and in particular, tea tree oil and aloe vera gel are It was found that the liquid composition for gargling, which is included in a ratio of 1:1 based on the weight of the components, exhibits excellent effects in removing plaque and inhibiting tooth decay.

In addition, the inventors of the present invention, while the liquid composition for gargling containing tea tree oil and aloe vera gel according to the present invention has the effect of removing plaque and inhibiting tooth decay, while propolis extract, tea tree oil and aloe vera gel It was found that the liquid composition for gargling contained together showed a more excellent effect in removing plaque and inhibiting tooth decay.

In addition, the inventors of the present invention found that the liquid composition for gargling containing cetylpyridinium chloride and sage extract according to the present invention has the effect of removing plaque and inhibiting tooth decay, and in particular, tea tree oil and aloe vera gel , And it was found that the liquid composition for gargling containing cetylpyridinium chloride and sage extract showed a more excellent effect in removing plaque and inhibiting tooth decay, and furthermore, sage extract, tea tree oil, and aloe vera gel were each component It was found that the liquid composition for gargling included in a ratio of 0.1: 1: 1 based on the weight of gargle had a particularly excellent effect in removing plaque and inhibiting tooth decay.

In addition, as the inventors of the present invention provide the liquid composition for gargling as a concentrated liquid composition for gargling, the user can mix a certain amount of the concentrated liquid composition for gargling with water to easily obtain a diluted liquid composition for gargling It can be obtained, and by directly adjusting the concentration of the active ingredient in the diluted liquid composition for gargling by the user, a diluted liquid composition for gargling of low concentration or high concentration is obtained as necessary, and conventionally diluted through use. It was found that it is possible to provide a liquid composition product for gargle with significantly improved portability and economy compared to liquid composition products for gargle distributed and sold.

1 is a flowchart schematically showing each step of preparing a liquid composition for gargling according to the present invention.

The technical terms used in the present invention are only used to describe the following embodiments, and are not intended to limit the scope of the present invention through the technical terms, and the technical terms are specifically used in the present invention. Unless the meaning is defined, it should be understood to convey the meaning commonly understood and used by a person skilled in the art (hereinafter referred to as "ordinary skill") to which the present invention belongs.

The present invention is not limitedly embodied by the means or forms described in this specification, and is easily substituted or modified by those skilled in the art within the principle of solving the technical problem to be solved by the present invention. It may be substituted or changed in a possible configuration, and it should be understood that a person skilled in the art can clearly recognize it based on the details described in this specification.

As used herein, the term 'and/or' is a term that includes each and every combination of one or more of the recited items. In addition, singular terms also include plural unless otherwise stated.

The terms 'comprising' and/or 'comprising' used in this specification are terms that do not exclude the presence or addition of other items other than the mentioned items.

In this specification, a numerical range expressed using the term 'to' indicates a numerical range including the values described before and after the term as the lower limit value and the upper limit value, respectively. When a plurality of numerical values are disclosed as the upper and lower limits of any numerical range, the numerical range disclosed in this specification includes any one of the plurality of lower limits and any one of the plurality of upper values, respectively. It can be understood as any numerical range with a lower limit and an upper limit.

As used herein, the terms 'about' or 'approximately', when used, mean a value or range of values that is within 10% of the value or range of values stated following the term.

Hereinafter, the present invention will be described in detail using the following examples.

In one embodiment of the present invention, the liquid composition for gargling according to the present invention is purified water; cetylpyridinium chloride; sage ex; concentrated glycerin; citric acid; sodium chloride; potassium sorbate; hydrogenated castor oil; sweetening agent; And it may be a concentrated liquid composition for gargling containing a flavoring agent.

In one embodiment of the present invention, the cetylpyridinium chloride contained in the liquid composition for gargling is 1.0 to 5.0% by weight, preferably 1.5 to 4.0% by weight, more preferably 2.0% by weight based on the weight of the total composition to 3.0% by weight, more preferably 2.1 to 2.5% by weight, and most preferably 2.2 to 2.4% by weight.

In one embodiment of the present invention, the liquid composition for gargling may further include papain, and when the papain is included, it may be included in an amount of 0.0005 to 0.002% by weight based on the weight of the total composition.

In one embodiment of the present invention, the liquid composition for gargling may further include pyridoxine hydrochloride, and when the pyridoxine hydrochloride is included, it may be included in an amount of 0.001 to 0.005% by weight based on the weight of the total composition.

In one embodiment of the present invention, the liquid composition for gargling may further include zinc oxide, and when the zinc oxide is included, it may be included in an amount of 0.01 to 1% by weight based on the weight of the total composition.

In one embodiment of the present invention, the sweetener included in the liquid composition for gargling may be a sweetener selected from the group including xylitol, sodium saccharin, various other sweeteners for improving the taste of the composition, and combinations thereof.

In one embodiment of the present invention, the flavoring agent included in the liquid composition for gargling may be a flavoring agent composed of a functional flavoring agent and a non-functional flavoring agent, and the functional flavoring agent is L-menthol, propolis extract, tea tree It may be a flavoring agent selected from the group comprising oils and combinations thereof, and the non-functional flavoring agent may include phytoncheat flavor, mint flavor, herb mint flavor, various non-functional flavorants for adding flavor to other compositions, and combinations thereof. It may be a flavoring agent selected from the group comprising

In a preferred embodiment of the present invention, the flavoring agent included in the liquid composition for gargling may be a flavoring agent composed of a functional flavoring agent and a non-functional flavoring agent, and the functional flavoring agent is L-menthol, propolis extract and tea It may be a functional flavoring agent composed of tree oil, and the non-functional flavoring agent may be a non-functional flavoring agent composed of phytoncite flavor, mint flavor, and herb mint flavor.

In a preferred embodiment of the present invention, the flavoring agent included in the liquid composition for gargling may be a functional flavoring agent and a non-functional flavoring agent, and the functional flavoring agent is L-menthol, citron extract, aloe vera It may be a functional flavoring agent composed of gel, propolis extract, and tea tree oil, and in particular, the tea tree oil and the aloe vera gel may be included in a ratio of 1:1 based on the weight of each component.

The tea tree oil is a kind of essential oil extracted from the tea tree, and has an antibacterial or antifungal effect against both gram-positive, gram-negative, and fungi, and exhibits particularly strong efficacy against tooth decay bacteria. It is a component known to have the characteristics of enhancing the effect and/or efficacy when used together with a polis extract.

The aloe vera gel is known to have an anti-inflammatory and/or antibacterial effect, a soothing effect when applied to the skin, etc., and an enhanced effect when used together with a propolis extract, It has the effect of improving symptoms such as oral lichen planus, oral submucosal fibrosis, recurrent aphthous stomatitis, alveolar osteitis, periodontitis, etc., and also strengthens the body's normal immune function, has the effect of preventing circulation disorders due to increased circulation, and has the effect of expanding blood vessels. It is a known ingredient.

The propolis extract is a component widely known to perform natural antibacterial, antifungal, antiviral and antioxidant functions, inhibits the growth of bacteria and / or bacteria in the oral cavity and has an excellent effect on removing bad breath, gums. It is known as a component having an effect of preventing diseases and removing and suppressing bacteria causing tooth decay, and contains vitamins A, B, E, and/or flavonoids, and the contained flavonoids attack the bacteria causing bad breath, It is an ingredient known to relieve bad breath.

The xylitol is a naturally-derived ingredient obtained from birch trees, and is known as a component that has a sweet taste and prevents various bacteria in the oral cavity that generate energy by ingesting sugar to eliminate energy.

The sage extract is known as a component that has an anti-inflammatory and/or antibacterial effect based on its excellent antioxidant effect, further suppresses and improves gum bleeding in the oral cavity, and improves immunity.

The zinc oxide performs the function of collecting bad breath gas that conveys bad breath, performs the function of removing bacteria that cause bad breath, has anti-inflammatory and / or antibacterial effects, inhibits and controls the formation of plaque in the oral cavity, , It is a component that suppresses the formation of calculus in the oral cavity, suppresses demineralization of the enamel constituting the tooth surface in the oral cavity and provides an effect of remineralization, suppresses and improves gum bleeding in the oral cavity, and improves immunity. It is known as a component that performs

The concentrated glycerin, as a humectant, is a component known to have a moisturizing effect and a moisture imparting effect by performing a function of suppressing the escape of moisture in the oral cavity, and the sodium chloride has an antibacterial effect, a gum disease preventive effect, and / or healing of oral ulcers It is a component known to perform the function of promoting.

The papain is a vegetable protease enzyme component extracted from papaya fruit, and is known to have an effect of removing plaque that causes tooth decay, while inhibiting tooth discoloration and improving whitening.

The phytoncite is a substance produced by plant species to counteract microorganisms, and is an organic substance having bactericidal and volatile properties, which removes bacteria that cause tooth decay and bacteria that cause gum disease or inhibits their reproduction. , It is a component known to have an effect of preventing the occurrence of plaque or inhibiting its formation.

Hereinafter, the present invention will be described in more detail using the following examples and comparative experimental examples.

Example : Preparation of the composition of Example 1

Purified water 852.69g, tea tree oil (CAS No. 68647-73-4) 1.0g, aloe vera gel 1.0g, cetylpyridinium chloride (CAS No. 6004-24-6), 22.96g, sage extract (CAS No. 8022-56-8) 0.1g, propolis extract (CAS No. 85665-41-4) 1.0g, papain (CAS No. 9001-73-4) 0.01g, pyridoxine hydrochloride (CAS No. 58-56-0 ) 0.04 g, concentrated glycerin (CAS No. 56-81-5) 50.0 g, citric acid (CAS No. 5949-27-1) 1.0 g, xylitol (CAS No. 87-99-0) 4.0 g, sodium saccharin ( CAS No. 6155-57-3) 12.0g, sodium chloride (CAS No. 7647-14-5) 1.0g, L-menthol (CAS No. 2216-51-5) 0.3g, phytoncite flavor (product name HF-6842, Obtained from Hanbit Perfume Co., Ltd.) 0.2g, mint flavor (product name: AH-F-2217, obtained from Hanbit Perfume Co.) 0.3g, herb mint flavor (product name: HF-6381, obtained from Hanbit Perfume Co.) 0.3g, potassium sorbate (CAS No. 24634-61-5) 3.0 g, and hydrogenated castor oil (CAS No. 61788-85-0) 50.0 g were weighed and prepared.

Each of the above components was put into a mixing tank and dissolved to form a mixture. The mixture was stirred at 2,800 to 2,300 RPM for 60 minutes while maintaining at 70 to 80 °C. Then, stirring was terminated and the stirred mixture was slowly cooled to 40° C. for 20 minutes. After confirming that the cooled composition was uniformly mixed in water and there was no precipitate, it was discharged into a storage container. The discharged composition was weighed in small portions of 50 g to prepare the composition of Example 1.

Comparative Experimental Example : Evaluation of Caries Inhibiting Effect

According to the KCL-FIR-1002:2021 method, an antibacterial test was conducted in an environment of 37.0 ± 0.2 ° C. The liquid Example 1 composition was used as a test sample. Streptococcus mutans (Streptococcus mutans) ATCC 25175 was used as the strain. The inoculum concentration was set at 1.8 x 10 ⁶ CFU/mL. When BLANK was applied, the initial strain concentration was defined as "A", when BLANK was applied, the strain concentration after 24 hours was defined as "B", and when the test sample was applied, the strain concentration after 24 hours was defined as "C". The bacteriostatic reduction rate (%) was calculated as [(BC)/B × 100], and the bactericidal reduction rate (%) was calculated as [(AC)/A × 100]. The evaluation results are shown in the following <Table 1>.

<Table 1>

According to the experimental results, the composition of Example 1 showed a bacteriostatic reduction rate of 99.9% and a sterilization reduction rate of 99.9% for mutans streptococci that cause tooth decay, compared to the case where the composition of Example 1 was not applied. It was confirmed that the bacteriostatic reduction rate and the sterilization reduction rate were exhibited, and thus it was confirmed that the composition of Example 1 had excellent efficacy in removing plaque and inhibiting cariogenic bacteria.

Claims (5)

A liquid composition for mouthwash containing purified water, tea tree oil, aloe vera gel, propolis extract, cetylpyridinium chloride and sage extract. The liquid composition for gargling according to claim 1, further comprising 0.0005 to 0.002% by weight of papain and 0.001 to 0.005% by weight of pyridoxine hydrochloride based on the weight of the total composition. The liquid composition for gargling according to claim 1 or 2, wherein the tea tree oil and the aloe vera gel are included in a ratio of 1:1 based on the weight of each component. The liquid composition for gargling according to claim 1 or 2, wherein the sage extract, the tea tree oil, and the aloe vera gel are included in a ratio of 0.1:1:1 based on the weight of each component. The liquid composition for gargling according to claim 1 or 2, wherein the cetylpyridinium chloride is contained in an amount of 1.0 to 5.0% by weight based on the weight of the total composition.

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