KR102612967B1 - Liquid compositions for oral use containing bifidus-ex - Google Patents
Liquid compositions for oral use containing bifidus-ex Download PDFInfo
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- KR102612967B1 KR102612967B1 KR1020230081684A KR20230081684A KR102612967B1 KR 102612967 B1 KR102612967 B1 KR 102612967B1 KR 1020230081684 A KR1020230081684 A KR 1020230081684A KR 20230081684 A KR20230081684 A KR 20230081684A KR 102612967 B1 KR102612967 B1 KR 102612967B1
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- oral
- present
- liquid composition
- extract
- composition
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Classifications
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
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Abstract
본 발명은 서울특별시 서울기술연구원 2022년도 캠퍼스타운 기술매칭 지원 사업 "교정 환자의 충치 예방 및 플라그 제거 등을 위한 구강 스프레이액 조성물"을 통해 개발된 기술이다.
본 발명은, 비피두스엑스, 클로브 오일, 로즈마리엑스, 산화아연, 및 세틸피리디늄염화물을 포함하는, 구강용 액상 조성물이 제공된다. 본 발명에 의하면 비피두스엑스를 포함하는 것을 통해 구강 내 이익균 성장에 유용하고 구취제거 효과가 우수한 구강용 액상 조성물이 제공될 수 있다.This invention is a technology developed through the 2022 Campus Town Technology Matching Support Project of the Seoul Research Institute of Technology in Seoul, “Oral spray composition for preventing cavities and removing plaque in orthodontic patients.”
The present invention provides a liquid composition for oral use containing bifidus extract, clove oil, rosemary extract, zinc oxide, and cetylpyridinium chloride. According to the present invention, an oral liquid composition that is useful for the growth of beneficial bacteria in the oral cavity and has an excellent bad breath removal effect can be provided by containing Bifidus Ex.
Description
본 발명은 구강용 액상 조성물에 관한 것으로, 보다 상세하게는 비피두스엑스를 포함하는 구강용 액상 조성물에 관한 것이고, 특히 에어로졸 형태로 분사될 수 있는 구강용 액상 조성물에 관한 것이다.The present invention relates to a liquid composition for oral use, and more specifically, to a liquid composition for oral use containing Bifidus Ex, and particularly to a liquid composition for oral use that can be sprayed in the form of an aerosol.
본 발명은 서울특별시 서울기술연구원 2022년도 캠퍼스타운 기술매칭 지원 사업 "교정 환자의 충치 예방 및 플라그 제거 등을 위한 구강 스프레이액 조성물"을 통해 개발된 기술이다.
구강은 소화기관 및 호흡기관의 입구로, 내부는 점막으로 이루어져 있고 혀와 잇몸, 치아 및 침샘 등이 배치된 기관이다. 구강에 음식물이 투입되면 저작을 통하여 음식물이 잘게 분쇄되고, 침샘에서 분비된 침이 상기 잘게 분쇄된 음식물과 혼합된 다음, 구강에 연결된 이후의 식도로 상기 혼합물이 이동한다. 이와 같은 기능이 수행되는 구강의 환경은, 각종 음식물 섭취 후 발생한 잔여 찌꺼기가 완전히 제거되지 않을 수 있고, 이로 인하여 구취, 플라그 생성, 충치, 잇몸 질환, 색소 침착 등과 같은 부정적인 변화에 노출된다.This invention is a technology developed through the 2022 Campus Town Technology Matching Support Project of the Seoul Research Institute of Technology in Seoul, “Oral spray composition for preventing cavities and removing plaque in orthodontic patients.”
The oral cavity is the entrance to the digestive and respiratory organs, and is an organ made up of mucous membranes and equipped with the tongue, gums, teeth, and salivary glands. When food is introduced into the oral cavity, the food is ground into fine pieces through mastication, saliva secreted from the salivary glands is mixed with the finely ground food, and then the mixture moves into the esophagus connected to the oral cavity. In the oral environment where such functions are performed, residual waste generated after consuming various foods may not be completely removed, resulting in exposure to negative changes such as bad breath, plaque production, cavities, gum disease, pigmentation, etc.
구취는 음식물 섭취 후 발생하는 잔여 음식물이 구강 내에 존재함에 따라, 상기 잔여 음식물의 부패나 구강 내 박테리아 및 곰팡이 등에 의한 상기 잔여 음식물의 대사에 의해 발생하는 불쾌한 냄새이며, 특정 음식물, 예를 들어 마늘과 같은 음식물을 섭취하는 경우, 해당 음식물에 특유하게 포함된 특정 성분에 의해 강한 구취가 발생하거나, 발생 후 구강 내 침과 같은 분비물에 의해 구취가 자연스럽게 억제되는 과정에 요구되는 시간이 증대될 수 있고, 일반적으로 황을 포함하는 기체, 대표적으로는 황화수소(H2S), 메틸메르캅탄(CH3SH) 및 디메틸설파이드(CH3SCH3) 등이 구취 유발 가스로 널리 알려져 있다.Bad breath is an unpleasant odor that occurs after food intake, as residual food exists in the oral cavity, and is caused by decay of the remaining food or metabolism of the remaining food by bacteria and mold in the oral cavity, and is caused by certain foods, such as garlic and When consuming the same food, strong bad breath may occur due to certain ingredients unique to the food, or the time required for the process of naturally suppressing bad breath after occurrence may increase due to secretions such as saliva in the mouth. In general, gases containing sulfur, such as hydrogen sulfide (H 2 S), methyl mercaptan (CH 3 SH), and dimethyl sulfide (CH 3 SCH 3 ), are widely known as gases that cause bad breath.
상기와 같은 구강 위생에 관한 문제점을 방지하거나 억제하기 위하여, 칫솔과 치약을 통한 양치를 통해 구강 내의 잔존 음식물 및 플라그 등을 제거하여, 구강 내의 환경을 위생적으로 관리하는 것이 일반적이며, 권고되고 있다. 치약은 통상적으로 계면활성제 및 연마제 등을 포함하며, 물리적 세척도구인 칫솔에 의해 사용됨으로써 구강 내, 특히 치아에 점착되어 잔존하는 음식물 및 기타 플라그 등을 제거하는 기능을 수행하게 된다.In order to prevent or suppress the problems related to oral hygiene as described above, it is generally recommended and recommended to maintain the oral environment hygienically by removing remaining food and plaque in the oral cavity by brushing the teeth with a toothbrush and toothpaste. Toothpaste typically contains surfactants and abrasives, and is used with a toothbrush, which is a physical cleaning tool, to remove food and other plaque that remains in the oral cavity, especially on teeth.
또한, 불소 및 치석 제거제 등의 다양한 활성성분을 함유한 치약이 개발되어 구강 위생에 부정적인 영향을 미치는 인자들을 효과적으로 제어하고 있다. 그러나, 보편적으로 입수할 수 있는 칫솔과 치약을 통한 양치는, 상기 칫솔의 형태에 따라 요망되는 수준으로 구강 내의 환경을 위생적으로 변화시키기에 충분하지 않을 수 있으며, 이러한 문제점을 극복하기 위해 치간칫솔, 치실 및/또는 가글용 액상 조성물을 통한 구강 위생 관리가 제안되고 있다.In addition, toothpastes containing various active ingredients such as fluoride and tartar removers have been developed to effectively control factors that negatively affect oral hygiene. However, brushing teeth with a commonly available toothbrush and toothpaste may not be sufficient to hygienically change the oral environment to the desired level depending on the type of toothbrush. To overcome this problem, an interdental brush, Oral hygiene management through dental floss and/or liquid compositions for gargling has been proposed.
치간칫솔 및 치실은, 칫솔이 닿지 못하는 부분의 치아 사이 공간 등에 위치한 음식물 찌꺼기 등을 제거하는 데에 효과적인 것으로 알려져 있다. 그러나, 치간칫솔 및 치실을 통한 구강 위생 관리는 일반적으로 칫솔을 통한 양치 후 진행되며, 상기 치간칫솔 및 치실을 사용하기 위한 시공간적 제약이 존재한다는 점에서 제한적이다.Interdental brushes and dental floss are known to be effective in removing food residue, etc. located in spaces between teeth in areas that a toothbrush cannot reach. However, oral hygiene management using an interdental brush and dental floss is generally carried out after brushing teeth with a toothbrush, and is limited in that there are spatial and temporal constraints for using the interdental brush and dental floss.
구강 스프레이를 통한 구강 위생 관리는, 칫솔 및 치약을 통한 양치 후, 치간칫솔 및/또는 치실을 사용한 구강 관리 후에, 또는 이와 같은 수단을 사용한 구강 관리가 이루어지지 않은 환경에서 구강 내 악취를 제거하고 구강 내 유해균의 번식을 억제함에 있어 효율적인 수단이다. 그러나, 종래의 구강 스프레이는 사용자의 구강 내에 분사되는 경우 단순히 사용자에게 청량감을 제공하는 효과만을 가지거나, 구강 스프레이용 액상 조성물에 포함된 향료 또는 향을 갖는 성분 고유의 향으로 구취를 감각하지 못하도록 하는 일시적인 효과만을 가진다는 문제점이 있었다.Oral hygiene management using oral spray removes bad odors in the oral cavity and cleans the oral cavity after brushing teeth with a toothbrush and toothpaste, after oral care using an interdental brush and/or dental floss, or in an environment where oral care using such means is not performed. It is an efficient means of suppressing the growth of harmful bacteria. However, the conventional oral spray simply has the effect of providing a refreshing feeling to the user when sprayed into the user's mouth, or prevents the user from feeling bad breath due to the inherent scent of the fragrance or scented ingredient contained in the liquid composition for oral spray. The problem was that it only had a temporary effect.
또한, 구강 내에 에어로졸 형태로 분사되는 구강 스프레이의 경우, 그 성분에 따라 구강 내의 수분 균형에 부정적인 영향을 미칠 수 있고, 이에 따라 전반적인 구강 건강에도 부정적인 영향을 미칠 수 있다는 문제점이 있었다.In addition, in the case of oral sprays sprayed in the form of aerosols in the oral cavity, there is a problem that depending on the ingredients, it may have a negative effect on the moisture balance in the oral cavity, which may also have a negative impact on overall oral health.
따라서, 구강용 액상 조성물로서 구강 스프레이를 통한 분사가 이루어지는 경우, 즉 에어로졸 형태로 분사되는 경우 구취 제거 효과를 가지면서도 구강 건강을 증진시킬 수 있는 효과를 갖는 구강용 액상 조성물이 요구되는 실정이다.Therefore, when a liquid composition for oral use is sprayed through an oral spray, that is, when sprayed in the form of an aerosol, there is a need for a liquid composition for oral use that has the effect of eliminating bad breath and improving oral health.
또한, 구강용 액상 조성물에 함유된 활성 성분의 유리한 효과를 극대화시켜, 종래의 구강용 액상 조성물에 비해 개선된 구강 내 박테리아 및 곰팡이 등의 유해인자의 제거 및 억제의 기능, 및 사용자의 구취 제거의 기능을 수행하는 구강용 액상 조성물이 요구된다.In addition, by maximizing the beneficial effects of the active ingredients contained in the oral liquid composition, the function of removing and suppressing harmful factors such as oral bacteria and mold is improved compared to conventional oral liquid compositions, and the user's bad breath removal function is improved compared to conventional oral liquid compositions. There is a need for an oral liquid composition that performs its function.
본 발명은 비피두스엑스를 포함하는 구강용 액상 조성물을 제공하여, 구취 제거에 효과적이고 구강 건강을 증진시킬 수 있는 조성물을 제공하고자 한다.The present invention seeks to provide a liquid composition for oral use containing Bifidus Ex, which is effective in removing bad breath and promoting oral health.
또한, 본 발명은 비피두스엑스, 비타민 C, 비타민 E, 구취제거 유효성분, 감미 성분, 및 기타 성분을 포함하는 구강용 액상 조성물을 제공하여, 구취 제거에 효과적이고 구강 건강을 증진시킬 수 있는 조성물을 제공하고자 한다.In addition, the present invention provides a liquid composition for oral use containing bifidus extract, vitamin C, vitamin E, bad breath removal active ingredients, sweetening ingredients, and other ingredients, and is effective in removing bad breath and promoting oral health. We would like to provide.
또한, 본 발명은 구취제거 유효성분으로서 레몬추출물, 모과추출물, 자일리톨, 및 효소처리스테비아를 포함하는 성분을 포함하는 구강용 액상 조성물을 제공하여, 자연스러운 구강 내 침 분비 유도로 구취를 제거하고 및 구강건조를 억제하는 조성물을 제공하고자 한다.In addition, the present invention provides an oral liquid composition containing ingredients including lemon extract, quince extract, xylitol, and enzyme-treated stevia as active ingredients for removing bad breath, and removes bad breath by inducing natural saliva secretion in the oral cavity. An object is to provide a composition that inhibits drying.
또한, 본 발명은 감미 성분으로서 클로브 오일 및 로즈마리엑스를 포함하는 구강용 액상 조성물로서, 상기 클로브 오일 및 상기 로즈마리엑스가 각 성분의 중량을 기준으로 2~3:1~2의 비율로 포함된 조성물을 제공하여, 구취 제거에 효과적이면서도 우수한 관능성을 갖는 조성물을 제공하고자 한다.In addition, the present invention is a liquid composition for oral use containing clove oil and rosemary extract as sweet ingredients, wherein the clove oil and rosemary extract are contained in a ratio of 2 to 3: 1 to 2 based on the weight of each component. The aim is to provide a composition that is effective in removing bad breath and has excellent sensory properties.
또한, 본 발명은 기타 성분으로서 산화아연 및 세틸피리디늄염화물을 포함하는 구강용 액상 조성물을 제공하여, 구취 제거에 효과적이면서도 우수한 관능성을 갖는 조성물을 제공하고자 한다.In addition, the present invention seeks to provide a liquid composition for oral use containing zinc oxide and cetylpyridinium chloride as other ingredients, and to provide a composition that is effective in removing bad breath and has excellent sensory properties.
또한, 본 발명은 감미 성분으로서 클로브 오일 및 로즈마리엑스를 포함하고, 기타 성분으로서 산화아연 및 세틸피리디늄염화물을 포함하는 구강용 액상 조성물을 제공하여, 구취 제거에 효과적이면서도 우수한 구취유발 가스 제거 효과를 갖는 조성물을 제공하고자 한다.In addition, the present invention provides an oral liquid composition containing clove oil and rosemary extract as sweetening ingredients and zinc oxide and cetylpyridinium chloride as other ingredients, which is effective in removing bad breath and has an excellent effect of removing gases that cause bad breath. The object is to provide a composition having the following.
또한, 본 발명은 알코올 성분을 포함하지 않는 것을 통해 구강건조를 예방하고 기타 성분으로서 알로에베라겔 성분을 포함하는 것을 통해 구강 수분감을 증진시킬 수 있는 조성물을 제공하고자 한다.In addition, the present invention seeks to provide a composition that prevents dry mouth by not containing alcohol and improves oral moisture by containing aloe vera gel as another ingredient.
또한, 본 발명은 에어로졸 형태로 분사될 수 있는 구강용 액상 조성물로서, 스프레이를 통해 분사될 수 있는 조성물을 제공하고자 한다.In addition, the present invention seeks to provide a liquid composition for oral use that can be sprayed in the form of an aerosol, and a composition that can be sprayed through a spray.
본 발명이 해결하고자 하는 과제들은 이상에서 언급한 과제로 제한되는 것은 아니며, 언급되지 않은 본 발명이 해결하고자 하는 과제들은 아래의 기재로부터 본 발명이 속하는 기술분야에서 보통의 지식을 가진 자("통상의 기술자")에게 명확하게 이해될 수 있을 것이다.The problems to be solved by the present invention are not limited to the problems mentioned above, and the problems to be solved by the present invention that are not mentioned above can be understood from the description below by anyone with ordinary knowledge in the technical field to which the present invention pertains. It will be clearly understandable to "technologists").
전술한 바와 같은 기술적 과제를 달성하기 위하여 제공되는 본 발명에 따른 구강용 액상 조성물은, 비피두스엑스, 비타민 C, 비타민 E, 구취제거 유효성분, 감미 성분, 및 기타 성분을 포함하는 구강용 액상 조성물일 수 있다.The oral liquid composition according to the present invention provided to achieve the technical problems described above is an oral liquid composition containing Bifidus Ex, Vitamin C, Vitamin E, a bad breath removal active ingredient, a sweetening ingredient, and other ingredients. It can be.
또한, 전술한 바와 같은 기술적 과제를 달성하기 위하여 제공되는 본 발명에 따른 구강용 액상 조성물은, 비피두스엑스, 비타민 C, 비타민 E, 레몬추출물, 모과추출물, 자일리톨, 효소처리스테비아, 감미 성분 및 기타 성분을 포함하는 구강용 액상 조성물일 수 있다.In addition, the oral liquid composition according to the present invention provided to achieve the technical problems described above includes bifidus extract, vitamin C, vitamin E, lemon extract, quince extract, xylitol, enzyme-treated stevia, sweetener ingredients and other ingredients. It may be an oral liquid composition containing ingredients.
또한, 전술한 바와 같은 기술적 과제를 달성하기 위하여 제공되는 본 발명에 따른 구강용 액상 조성물은, 비피두스엑스, 비타민 C, 비타민 E, 레몬추출물, 모과추출물, 자일리톨, 효소처리스테비아, 클로브 오일, 로즈마리엑스, 및 기타 성분을 포함하는 구강용 액상 조성물일 수 있다.In addition, the oral liquid composition according to the present invention provided to achieve the technical problems described above includes bifidus extract, vitamin C, vitamin E, lemon extract, quince extract, xylitol, enzyme-treated stevia, clove oil, and rosemary. It may be an oral liquid composition containing extract, and other ingredients.
또한, 전술한 바와 같은 기술적 과제를 달성하기 위하여 제공되는 본 발명에 따른 구강용 액상 조성물은, 비피두스엑스, 비타민 C, 비타민 E, 레몬추출물, 모과추출물, 자일리톨, 효소처리스테비아, 클로브 오일, 로즈마리엑스, 산화아연, 및 세틸피리디늄염화물을 포함하는 구강용 액상 조성물일 수 있다.In addition, the oral liquid composition according to the present invention provided to achieve the technical problems described above includes bifidus extract, vitamin C, vitamin E, lemon extract, quince extract, xylitol, enzyme-treated stevia, clove oil, and rosemary. It may be an oral liquid composition containing extract, zinc oxide, and cetylpyridinium chloride.
또한, 전술한 바와 같은 기술적 과제를 달성하기 위하여 제공되는 본 발명에 따른 구강용 액상 조성물은, 비피두스엑스, 비타민 C, 비타민 E, 레몬추출물, 모과추출물, 자일리톨, 효소처리스테비아, 클로브 오일, 로즈마리엑스, 산화아연, 세틸피리디늄염화물, 및 알로에베라겔 성분을 포함하는 구강용 액상 조성물일 수 있다.In addition, the oral liquid composition according to the present invention provided to achieve the technical problems described above includes bifidus extract, vitamin C, vitamin E, lemon extract, quince extract, xylitol, enzyme-treated stevia, clove oil, and rosemary. It may be an oral liquid composition containing extract, zinc oxide, cetylpyridinium chloride, and aloe vera gel.
또한, 전술한 바와 같은 기술적 과제를 달성하기 위하여 제공되는 본 발명에 따른 구강용 액상 조성물은, 알코올 성분을 포함하지 않는 구강용 액상 조성물일 수 있다. In addition, the oral liquid composition according to the present invention provided to achieve the above-mentioned technical problem may be an oral liquid composition that does not contain an alcohol component.
또한, 전술한 바와 같은 기술적 과제를 달성하기 위해 제공되는 본 발명에 따른 구강용 액상 조성물은, 인공색소를 포함하지 않는 것을 통해 치아에 대한 착색을 방지할 수 있는 구강용 액상 조성물일 수 있다.In addition, the liquid composition for oral use according to the present invention provided to achieve the technical problem described above may be a liquid composition for oral use that can prevent staining of teeth by not containing artificial pigments.
또한, 전술한 바와 같은 기술적 과제를 달성하기 위하여 제공되는 본 발명에 따른 구강용 액상 조성물은, 에어로졸 형태로 분사될 수 있는 구강용 액상 조성물로서, 스프레이를 통해 분사될 수 있는 구강용 액상 조성물일 수 있다.In addition, the oral liquid composition according to the present invention provided to achieve the technical problem described above is an oral liquid composition that can be sprayed in the form of an aerosol, and may be an oral liquid composition that can be sprayed through a spray. there is.
본 발명에 의하면 비피두스엑스를 포함하는 것을 통해 구강 내 이익균 성장에 유용하고 구취제거 효과가 우수한 구강용 액상 조성물이 제공될 수 있다.According to the present invention, an oral liquid composition that is useful for the growth of beneficial bacteria in the oral cavity and has an excellent bad breath removal effect can be provided by containing Bifidus Ex.
또한, 본 발명에 의하면 레몬추출물, 모과추출물, 자일리톨, 및 효소처리스테비아를 포함하는 것을 통해 신맛과 단맛의 균형을 통한 자연스러운 침 분비 유도로 구취제거 효과 및 구강건조 방지 효과가 우수한 구강용 액상 조성물이 제공될 수 있다.In addition, according to the present invention, an oral liquid composition containing lemon extract, quince extract, xylitol, and enzyme-treated stevia is excellent in removing bad breath and preventing dry mouth by inducing natural salivation through the balance of sourness and sweetness. can be provided.
또한, 본 발명에 의하면 클로브 오일 및 로즈마리엑스를 포함하고 상기 클로브 오일 및 상기 로즈마리엑스가 각 성분의 중량을 기준으로 2~3:1~2의 비율로 포함된 조성물을 제공하여, 효과적으로 구취를 제거하면서도 뛰어난 구중청량 효과를 제공하고 우수한 항균 효과를 갖는 구강용 액상 조성물이 제공될 수 있다.In addition, according to the present invention, a composition containing clove oil and rosemary extract is provided in a ratio of 2 to 3: 1 to 2 based on the weight of each component, effectively eliminating bad breath. A liquid composition for oral use can be provided that provides an excellent mouth-refreshing effect and has an excellent antibacterial effect.
또한, 본 발명에 의하면 산화아연 및 세틸피리디늄염화물을 포함하는 것을 통해 구취 제거에 효과적이면서도 우수한 항균 효과를 갖는 구강용 액상 조성물이 제공될 수 있다.In addition, according to the present invention, an oral liquid composition can be provided that is effective in removing bad breath and has an excellent antibacterial effect by containing zinc oxide and cetylpyridinium chloride.
또한, 본 발명에 의하면 클로브 오일 및 로즈마리엑스를 포함하고, 산화아연 및 세틸피리디늄염화물을 포함하는 것을 통해 더욱 우수한 구취 제거 효과 및 구중청량 효과를 갖는 구강용 액상 조성물이 제공될 수 있다.In addition, according to the present invention, an oral liquid composition containing clove oil and rosemary extract, and zinc oxide and cetylpyridinium chloride, can be provided, which has a better bad breath removal effect and breath freshening effect.
또한, 본 발명에 의하면 알코올 성분을 포함하지 않는 것을 통해 구강건조를 방지할 수 있는 구강용 액상 조성물이 제공될 수 있고, 알로에베라겔 성분을 포함하는 것을 통해 구강 수분감을 증진시킬 수 있는 구강용 액상 조성물이 제공될 수 있다.In addition, according to the present invention, a liquid composition for oral use can be provided that can prevent dry mouth by not containing an alcohol component, and can improve oral moisture by containing an aloe vera gel component. This can be provided.
또한, 본 발명에 의하면 인공색소를 포함하지 않는 것을 통해 치아에 대한 착색을 방지할 수 있는 구강용 액상 조성물이 제공될 수 있다.In addition, according to the present invention, an oral liquid composition that can prevent staining of teeth by not containing artificial pigments can be provided.
또한, 본 발명에 의하면 에어로졸 형태로 분사될 수 있고, 스프레이를 통해 분사될 수 있는 조성물을 제공하여 편리하게 구취제거 및 구중청량 효과를 제공할 수 있는 구강용 액상 조성물이 제공될 수 있다.In addition, according to the present invention, a liquid composition for oral use can be provided that can conveniently remove bad breath and provide a breath-refreshing effect by providing a composition that can be sprayed in the form of an aerosol or sprayed.
본 발명에 따른 우수한 및/또는 유용한 효과는 상기한 본 발명의 효과로 제한되는 것이 아니고, 통상의 기술자는 본 명세서의 개시를 바탕으로 본 명세서에 명시적으로 개시되지 않은 본 발명의 우수한 및/또는 유용한 효과를 또한 자명하게 인식할 수 있을 것이며, 이는 본 명세서가 의도적으로 개시하는 것으로서, 본 개시의 범위에 자명하게 포함됨이 이해되어야 한다.The excellent and/or useful effects according to the present invention are not limited to the above-described effects of the present invention, and those skilled in the art can recognize the excellent and/or useful effects of the present invention not explicitly disclosed herein based on the disclosure of the present specification. Useful effects will also be readily apparent, and it should be understood that this is intentionally disclosed by this specification and is clearly included within the scope of the present disclosure.
도 1은 본 발명에 따른 가글용 액상 조성물의 항균력 평가 결과를 나타낸 도이다.Figure 1 is a diagram showing the results of evaluating the antibacterial activity of the liquid composition for gargling according to the present invention.
이하, 본 발명에 대하여 상세히 설명한다.Hereinafter, the present invention will be described in detail.
본 명세서 및 특허청구범위에 사용된 용어 또는 단어는 통용되는 사전적 의미로 한정하여 해석되도록 의도된 것이 아니며, 본 발명이 속하는 기술분야에서 보통의 지식을 가진 자는 상기 용어 또는 단어를 본 명세서 및 특허청구범위가 자명하게 전달하고자 하는 관념을 표현하는 범위 내에서 본 발명이 의미하는 바를 전달하기 위한 범위의 의미로 사용된 것으로 명확하게 이해할 수 있을 것이다.The terms or words used in this specification and patent claims are not intended to be construed as limited to their commonly used dictionary meanings, and those of ordinary skill in the technical field to which the present invention pertains should not use the terms or words in this specification and patent claims. It can be clearly understood that the claims are used in the sense of a scope for conveying the meaning of the present invention within the scope of expressing the idea that is clearly intended to be conveyed.
또한, 본 명세서에 기재된 실시예 및 상기 실시예에 기재된 구성들은 통상의 기술자에게 본 발명이 이해되고 또 이를 재현할 수 있도록 하기 위해 단지 예시로 제시된 바람직한 실시예에 불과할 뿐이고, 본 발명을 이에 한정시키고자 하는 의도가 아님을 통상의 기술자는 명확하게 이해할 수 있을 것이다.In addition, the embodiments described in this specification and the configurations described in the above embodiments are merely preferred embodiments presented as examples to enable those skilled in the art to understand and reproduce the present invention, and the present invention is limited thereto. A person skilled in the art will be able to clearly understand that this is not the intention.
또한, 본 명세서에서 기술되는 각각의 구성에 관한 설명 및 구체적인 실시 양태는 각각의 다른 설명 및 실시 양태에도 자명하게 적용될 수 있다. 즉, 본 명세서에서 개시되는 다양한 구성과 구체적인 실시 양태의 모든 조합은 본 발명이 개시하는 범위에 속하는 것으로 통상의 기술자는 명확하게 이해할 수 있을 것이다.In addition, the description and specific implementation aspects of each configuration described in this specification can be obviously applied to each other description and implementation aspect. That is, those skilled in the art will clearly understand that all combinations of various configurations and specific embodiments disclosed in this specification fall within the scope disclosed by the present invention.
본 명세서에서 사용되는 용어 '및/또는'은, 언급된 항목들의 각각 및 하나 이상의 모든 조합을 포함하는 용어이다. 또한, 단수형 용어는 별도로 언급되지 않는 한 복수형도 포함한다.The term 'and/or' used in this specification is a term that includes each and all combinations of one or more of the mentioned items. Additionally, singular terms also include plural terms unless otherwise noted.
본 명세서에서 사용하는 '포함한다(comprising)' 및/또는 '포함하는(comprising)'의 용어는 언급된 항목들 외의 다른 항목의 존재 또는 추가를 배제하지 않는 용어이다.The terms 'comprising' and/or 'comprising' used in this specification are terms that do not exclude the presence or addition of items other than the mentioned items.
본 명세서에서 용어 '내지'를 사용하여 나타낸 수치의 범위는, 상기 용어의 앞과 뒤에 기재된 값을 각각 하한 값과 상한 값으로써 포함하는 수치의 범위를 나타낸다. 임의의 수치 범위의 상한과 하한으로서의 수치 값이 각각 복수 개로 개시된 경우, 본 명세서에서 개시하는 수치의 범위는 복수의 하한 값 중 임의의 하나의 값 및 복수의 상한 값 중 임의의 하나의 값을 각각 하한 값 및 상한 값으로 하는 임의의 수치의 범위로 이해될 수 있다.The range of values expressed using the term 'to' in this specification refers to the range of values that include the values described before and after the term as the lower limit and upper limit, respectively. When a plurality of numerical values as the upper and lower limits of an arbitrary numerical range are disclosed, the numerical range disclosed in this specification includes any one value among the plurality of lower limit values and any one value among the plurality of upper limit values, respectively. It can be understood as a range of arbitrary values with a lower limit and an upper limit.
본 명세서에서 사용되는 용어 '약' 또는 '대략'은, 사용되는 경우, 상기 용어의 뒤에 기재된 값 또는 수치 범위의 10% 이내의 값 또는 수치 범위를 의미한다.As used herein, the term 'about' or 'approximately', when used, means a value or numerical range within 10% of the value or numerical range stated after the term.
본 명세서 및 특허청구범위에 사용된 용어 또는 단어는 통상적인 사전적인 의미로 한정해서 해석되어서는 안 되며, 발명자는 그 자신의 발명을 가장 최선의 방법으로 설명하기 위해 용어의 개념을 적절하게 정의할 수 있다는 원칙에 입각하여 본 발명의 기술적 사상에 부합하는 의미와 개념으로 해석되어야 한다. 따라서, 본 명세서에 기재된 실시예에 기재된 구성은 본 발명의 가장 바람직한 일 실시예에 불과할 뿐이고, 본 발명의 기술적 사상을 모두 대변하는 것은 아니므로, 본 출원시점에 있어서 이들을 대체할 수 있는 다양한 균등물과 변형예들이 있을 수 있음을 이해하여야 한다. Terms or words used in this specification and claims should not be construed as limited to their ordinary dictionary meanings, and the inventor may appropriately define the concept of terms in order to explain his or her invention in the best way. It should be interpreted with meaning and concept consistent with the technical idea of the present invention based on the principle that it can be done. Therefore, the configuration described in the embodiments described in this specification is only one of the most preferred embodiments of the present invention, and does not represent the entire technical idea of the present invention, so various equivalents can be substituted for them at the time of filing the present application. It should be understood that there may be variations.
한편, 본 명세서에서 개시된 각각의 설명 및 실시형태는 각각의 다른 설명 및 실시 양태에도 적용될 수 있다. 즉, 본 명세서에서 개시된 다양한 요소들의 모든 조합이 본 발명의 범주에 속하고, 일 구현예에서 생략된 기재는 다른 구현예에서 기재된 바와 같은 방식으로 해석될 수 있다. 또한, 하기 기술된 구체적인 서술에 의하여 본 발명의 범주가 제한된다고 볼 수 없다.Meanwhile, each description and embodiment disclosed in this specification may also be applied to each other description and embodiment. That is, all combinations of various elements disclosed in this specification fall within the scope of the present invention, and descriptions omitted in one embodiment may be interpreted in the same way as described in other embodiments. Additionally, the scope of the present invention cannot be considered limited by the specific description described below.
본 발명의 일 측면에 따르면, 본 발명에 따른 구강용 액상 조성물은 비피두스엑스, 비타민 C, 비타민 E, 구취제거 유효성분, 감미 성분, 및 기타 성분을 포함하는 구강용 액상 조성물일 수 있다.According to one aspect of the present invention, the oral liquid composition according to the present invention may be an oral liquid composition containing bifidus extract, vitamin C, vitamin E, a bad breath removal active ingredient, a sweetening ingredient, and other ingredients.
상기 비피두스엑스는, 파라프로바이오틱스로서 비피더스균(Bifidobacterium bifidum)로부터 얻은 추출물로, 구강이익균을 성장시키고, 플라그 감소 효과, 잇몸 출혈 감소 효과, 잇몸 질환 억제 효과, 구강내 유해세균 감소 효과, 및 구취 원인균 감소 효과를 제공할 수 있는 성분으로, 본 발명에 따른 조성물에 포함됨에 따라 본 발명에 따른 조성물은 잇몸질환균 및 입냄새균 감소 효과와 전반적인 구강 건강 증진 효과를 제공할 수 있다.The Bifidus As an ingredient that can provide a reducing effect, when included in the composition according to the present invention, the composition according to the present invention can provide the effect of reducing gum disease bacteria and bad breath bacteria and improving overall oral health.
상기 비피두스엑스는, 전체 조성물을 기준으로 500 내지 1500ppm으로 포함될 수 있다. 상기 비피두스엑스가 전체 조성물을 기준으로 500ppm 미만으로 포함되는 경우, 조성물이 제공됨에 따른 구취제거 및 구중청량 효과가 충분하지 않다는 문제점이 있고, 상기 비피두스엑스가 전체 조성물을 기준으로 1500ppm 초과로 포함되는 경우, 구강 내 각종 균의 균형이 무너질 수 있다는 문제점이 있으므로, 상기 비피두스엑스의 함량은 상기 수치범위를 만족하는 것이 바람직하다.The Bifidus Ex may be included in an amount of 500 to 1500 ppm based on the total composition. If the Bifidus Ex is contained in an amount of less than 500ppm based on the entire composition, there is a problem that the bad breath removal and breath-refreshing effects provided by the composition are not sufficient, and the Bifidus Ex is contained in an amount of more than 1500ppm based on the entire composition. In this case, there is a problem that the balance of various bacteria in the oral cavity may be disrupted, so it is preferable that the content of Bifidus Ex satisfies the above numerical range.
상기 비타민 C는, 아스코르브산나트륨일 수 있고, 구강 세포의 면역을 활성화할 수 있는 성분일 수 있으며, 상처 치유, 감염에 대한 저항을 통한 구강조직의 건강 증진, 및 콜라겐 합성 촉진을 통한 구강조직의 재생 개선의 효과를 제공할 수 있다.The vitamin C may be sodium ascorbate, and may be an ingredient that can activate the immunity of oral cells, promote oral tissue health through wound healing and resistance to infection, and promote collagen synthesis. It can provide the effect of improving playback.
상기 비타민 C가 본 발명에 따른 조성물에 포함됨에 따라, 본 발명에 따른 조성물은 비타민C에 의한 충치균 억제 효과, 구취 유발 세균 증식 억제 효과, 치아 구조 지지 효과, 치아 재광화 유도 효과, 어린이 이차 우식 발병 감소 효과를 제공할 수 있고, 비타민C에 의한 잇몸출혈 감소, 치석침착 억제, 항염증 효과, 항산화 및 상처 치유 촉진 효과를 제공할 수 있다.As the vitamin C is included in the composition according to the present invention, the composition according to the present invention has an effect of suppressing caries bacteria due to vitamin C, an effect of suppressing the growth of bacteria causing bad breath, an effect of supporting tooth structure, an effect of inducing tooth remineralization, and the development of secondary caries in children. It can provide a reduction effect, reduce gum bleeding due to vitamin C, suppress tartar deposition, anti-inflammatory effect, antioxidant, and promote wound healing.
상기 비타민 E는, 토코페롤아세테이트일 수 있고, 구강 내 혈액순환을 촉진시키고, 염증 억제 및 구강 내 치유 효과를 제공할 수 있으며, 강력한 항산화 효과를 제공하고, 구강 세포막의 견고성을 향상시킬 수 있다.The vitamin E may be tocopherol acetate and can promote blood circulation in the oral cavity, suppress inflammation and provide oral healing effects, provide a strong antioxidant effect, and improve the robustness of oral cell membranes.
본 발명의 일 실시예에 따르면, 상기 구취제거 유효성분은 레몬추출물, 모과추출물, 자일리톨, 및 효소처리스테비아를 포함할 수 있다.According to one embodiment of the present invention, the active ingredient for removing bad breath may include lemon extract, quince extract, xylitol, and enzyme-treated stevia.
상기 레몬추출물은, Streptococcus mutans , Prevotella intermedia , Porphyromonas gingivalis 에 대한 항균 효과를 나타내는 것으로 알려져 있고, 타액 유속 증가 등의 효과를 제공하여 침분비를 활성화시켜 구강건조를 방지할 수 있다.The lemon extract is known to have an antibacterial effect against Streptococcus mutans, Prevotella intermedia, and Porphyromonas gingivalis, and can prevent dry mouth by activating salivary secretion by providing effects such as increasing saliva flow rate.
상기 자일리톨은, 자작나무에서 얻어지는 자연 유래 내지는 천연 유래 성분으로, 단맛을 내는 성분이고, 구취를 발생시키는 원인균이 당을 섭취하지 못하도록 하여 사멸하도록 하는 효과를 가지는 것으로 알려져 있다.The xylitol is a natural or natural ingredient obtained from birch trees, is a sweetening ingredient, and is known to have the effect of preventing bacteria that cause bad breath from ingesting sugar and causing them to die.
상기 효소처리스테비아는, 스테비아에서 얻어지는 자연 유래 내지는 천연 유래 성분으로, 단맛을 내는 성분이고, 구취를 발생시키는 원인균이 당을 섭취하지 못하도록 하여 사멸하도록 하는 효과를 가지는 것으로 알려져 있으며, 단맛을 제공하여 자연스러운 침분비를 유도하는 것을 통해 구강건조를 방지할 수 있다.The enzyme-treated stevia is a natural or naturally derived ingredient obtained from stevia, and is an ingredient that gives a sweet taste. It is known to have the effect of preventing bacteria that cause bad breath from ingesting sugar and causing them to die, and it provides a natural taste by providing a sweet taste. Dry mouth can be prevented by inducing saliva secretion.
본 발명의 일 실시예에 의하면, 상기 감미 성분은 클로브 오일 및 로즈마리엑스를 포함할 수 있다.According to one embodiment of the present invention, the sweet ingredient may include clove oil and rosemary extract.
상기 클로브 오일은, 정향 나무에서 추출한 에센셜 오일로, 연한 노란색을 나타내고, 항균제로 사용되며, 치통에 대한 진통제로 사용되고, 특히 다양한 균류의 성장을 저해하는 효과를 가지는 성분이고, 치아의 부식을 예방함에 있어 효과적인 성분이다.The clove oil is an essential oil extracted from the clove tree, has a light yellow color, is used as an antibacterial agent, and an analgesic for toothache. In particular, it is an ingredient that has the effect of inhibiting the growth of various fungi and prevents tooth decay. It is an effective ingredient.
상기 로즈마리엑스는, 세균 및 곰팡이의 성장을 저해하는 역할을 수행하며, 필요에 따라 약한 진통제로 사용될 수 있고, 순환 증가에 따른 순환 장애의 예방 효과 및 혈관 확장 효과를 가지는 것으로 알려진 성분이다.The rosemary extract plays a role in inhibiting the growth of bacteria and mold, can be used as a mild painkiller if necessary, and is an ingredient known to have a vasodilating effect and prevent circulatory disorders due to increased circulation.
상기 클로브 오일 및 상기 로즈마리엑스는 각 성분의 중량을 기준으로 (2.5~3.5):(1.5~0.5)의 비율로 포함될 수 있다. 상기 클로브 오일 및 상기 로즈마리엑스의 비율이 상기 수치범위를 만족하는 경우, 본 발명에 따른 구강용 액상 조성물이 제공됨에 따른 구취제거 효과 및 구중청량 효과가 뛰어날 수 있고, 특히 클로브 오일 및 로즈마리엑스가 각각 제공되는 경우와 비교하였을 때 현저히 우수한 구취제거 효과가 제공될 수 있다.The clove oil and rosemary extract may be included in a ratio of (2.5 to 3.5):(1.5 to 0.5) based on the weight of each ingredient. When the ratio of the clove oil and the rosemary extract satisfies the above numerical range, the oral liquid composition according to the present invention can provide excellent bad breath removal and mouth refreshing effects, and in particular, clove oil and rosemary extract are each Compared to the case where it is provided, a significantly superior bad breath removal effect can be provided.
본 발명의 일 실시예에 의하면, 상기 감미 성분은 프로폴리스 및 로얄젤리를 추가로 포함할 수 있다.According to one embodiment of the present invention, the sweet ingredient may further include propolis and royal jelly.
상기 프로폴리스는, 자연 유래 항박테리아, 항진균, 항바이러스 및 항산화 기능을 수행하는 것으로 널리 알려진 성분으로, 구강 내 박테리아 및/또는 세균의 번식을 억제하고 구취 제거에 탁월한 효과를 가지는 성분이며, 잇몸 질환의 예방 효과 및 충치 원인세균의 제거 및 억제 효과를 가지는 성분으로 알려져 있고, 비타민 A, B, E, 및/또는 플라보노이드를 함유하고 있으며, 상기 함유된 플라보노이드 성분이 구취를 유발하는 원인균을 공격하여 구취를 완화하는 것으로 알려진 성분이다.The propolis is a widely known ingredient that performs natural antibacterial, antifungal, antiviral and antioxidant functions, and is an ingredient that inhibits the growth of bacteria and/or bacteria in the oral cavity and has an excellent effect in eliminating bad breath and gum disease. It is known as an ingredient that has a preventive effect and an effect of removing and suppressing bacteria that cause tooth decay, and contains vitamins A, B, E, and/or flavonoids, and the flavonoids contained above attack the bacteria that cause bad breath, reducing bad breath. It is an ingredient known to relieve.
상기 로얄젤리는, 꿀벌 중 여왕벌이 될 벌이 알에서 깨어나서 여왕벌이 될 때까지 섭취하는 성분으로, 구강 내 적혈구 생성 및 내당능 개선에 효과적이며, 구강 점막염 감소에 효과적인 성분이다.The royal jelly is an ingredient that bees consume when they hatch from eggs until they become queen bees. It is effective in improving oral red blood cell production and glucose tolerance, and is an effective ingredient in reducing oral mucositis.
본 발명의 일 실시예에 의하면, 상기 기타 성분은 산화아연 및 세틸피리디늄염화물을 포함할 수 있다.According to one embodiment of the present invention, the other ingredients may include zinc oxide and cetylpyridinium chloride.
상기 세틸피리디늄염화물은, 충치, 각종 잇몸병의 원인균을 제거하는 데에 효과적인 성분으로, 항염 및 항균 효과를 가지고, 구취를 유발하는 원인세균의 번식을 억제할 수 있는 성분이다.The cetylpyridinium chloride is an effective ingredient in removing bacteria that cause cavities and various gum diseases, has anti-inflammatory and antibacterial effects, and is an ingredient that can inhibit the growth of bacteria that cause bad breath.
상기 세틸피리디늄염화물은, 전체 조성물의 중량을 기준으로 1.0 내지 5.0중량%, 바람직하게는 1.5 내지 4.0중량%, 보다 바람직하게는 2.0 내지 3.0중량%, 더욱 바람직하게는 2.1 내지 2.5중량%, 가장 바람직하게는 2.2 내지 2.4중량%로 포함될 수 있다.The cetylpyridinium chloride is contained in an amount of 1.0 to 5.0% by weight, preferably 1.5 to 4.0% by weight, more preferably 2.0 to 3.0% by weight, even more preferably 2.1 to 2.5% by weight, based on the weight of the total composition. Preferably, it may be included in 2.2 to 2.4% by weight.
상기 산화아연은, 구취를 전달하는 구취 가스를 포집하는 기능을 수행하며, 구취를 발생시키는 세균을 제거하는 기능을 수행하고, 항염 및/또는 항균 효과를 가지며, 구강 내 플라그의 형성을 억제 및 제어하고, 구강 내 치석의 형성을 억제하는 성분으로, 구강 내의 치아 표면을 구성하는 법랑질의 탈회를 억제하고 재광화하는 효과를 제공하는 성분이고, 구강 내의 잇몸 출혈을 억제 및 개선하며, 면역력을 향상시키는 기능을 수행하는 성분으로 알려져 있다.The zinc oxide performs the function of collecting bad breath gas that transmits bad breath, removes bacteria that cause bad breath, has anti-inflammatory and/or antibacterial effects, and inhibits and controls the formation of plaque in the oral cavity. It is an ingredient that suppresses the formation of tartar in the oral cavity, suppresses demineralization and remineralizes the enamel that makes up the surface of teeth in the oral cavity, suppresses and improves gum bleeding in the oral cavity, and improves immunity. It is known as an ingredient that performs a function.
본 발명의 일 실시예에 의하면, 상기 기타 성분은 알로에베라겔 성분을 추가로 포함할 수 있다.According to one embodiment of the present invention, the other ingredients may further include an aloe vera gel ingredient.
상기 알로에베라겔 성분은, 알로에의 한 품종 중 하나인 알로에베라에서 추출한 에센셜 성분으로, 프로폴리스와 함께 포함되는 경우 상승효과를 나타내어 구강세균의 제거 및 성장 억제에 효과적이며, 항염증, 항균, 및 진정 효과를 제공하고, 성분에 포함된 안트라퀴논 성분을 통해 구강질환의 발생을 방지하고, 구취를 유발하는 세균을 억제함에 있어 효과적인 성분이며, 나아가 구강 편평태선, 구강점막하 섬유증, 재발성 아프타 구내염, 치조골염, 치주염 등 각종 구강 질환에 효과적인 성분이다.The aloe vera gel component is an essential ingredient extracted from aloe vera, one of the varieties of aloe. When included with propolis, it has a synergistic effect and is effective in removing and inhibiting the growth of oral bacteria, and has anti-inflammatory, antibacterial, and soothing properties. It is an effective ingredient in preventing the occurrence of oral diseases and suppressing bacteria that cause bad breath through the anthraquinone contained in the ingredient, and furthermore, oral lichen planus, oral submucosal fibrosis, recurrent aphthous stomatitis, and alveolar osteitis. It is an effective ingredient for various oral diseases such as periodontitis.
본 발명의 일 실시예에 의하면, 상기 기타 성분은 농글리세린 성분을 추가로 포함할 수 있다.According to one embodiment of the present invention, the other ingredients may additionally include concentrated glycerin.
상기 농글리세린은 습윤제로서, 구강 내의 수분의 이탈을 억제하는 기능을 수행하여 보습 효과 및 습윤 부여 효과를 가지는 것으로 알려져 있는 성분이고, 상기 염화나트륨은 항균 효과, 잇몸 질환 예방 효과 및/또는 구강 궤양의 치유를 촉진하는 기능을 수행하는 것으로 알려져 있는 성분이다.The concentrated glycerin is a humectant and is known to have a moisturizing effect and a moisturizing effect by performing the function of suppressing the escape of moisture in the oral cavity, and the sodium chloride has an antibacterial effect, a gum disease prevention effect, and/or an oral ulcer healing effect. It is an ingredient known to perform the function of promoting .
본 발명의 일 실시예에 의하면, 본 발명에 따른 조성물은 알코올 성분을 포함하지 않을 수 있다.According to one embodiment of the present invention, the composition according to the present invention may not contain an alcohol component.
상기 알코올 성분은 유기 알코올 성분으로서, 예를 들어 에틸알코올 및 프로필알코올과 같은 알코올기를 갖는 성분일 수 있다. 상기 알코올 성분이 포함되지 않는 것을 통해, 본 발명에 따른 조성물은 구강에 적용되는 경우 구강건조의 발생을 방지할 수 있다.The alcohol component may be an organic alcohol component, for example, a component having an alcohol group such as ethyl alcohol and propyl alcohol. By not containing the alcohol component, the composition according to the present invention can prevent the occurrence of dry mouth when applied to the oral cavity.
본 발명의 일 실시예에 의하면, 본 발명에 따른 조성물은 착향제를 추가로 포함할 수 있다.According to one embodiment of the present invention, the composition according to the present invention may further include a flavoring agent.
상기 착향제는 레드와인향, 민트향, 허브민트향, 기타 조성물에 향을 부가하기 위한 다양한 비기능성 착향제 및 이들의 조합을 포함하는 군으로부터 선택된 착향제일 수 있다.The flavoring agent may be a flavoring agent selected from the group including red wine flavor, mint flavor, herb mint flavor, various non-functional flavoring agents for adding flavor to other compositions, and combinations thereof.
상기 레드와인추출물은, 항염 및/또는 항균 효과를 가지며, 상기 레드와인추출물에 함유된 폴리페놀 성분에 의한 항산화 기능을 수행하는 성분으로, 함량에 따라 기능성 착향제 또는 비기능성 착향제일 수 있는 성분이다. The red wine extract is an ingredient that has anti-inflammatory and/or antibacterial effects and performs an antioxidant function due to the polyphenol component contained in the red wine extract, and may be a functional flavoring agent or a non-functional flavoring agent depending on the content. .
이하, 본 발명을 하기 실시예를 사용하여 더욱 상세하게 설명한다.Hereinafter, the present invention will be explained in more detail using the following examples.
실시예 1: 실시예 1 조성물의 제조Example 1: Preparation of Example 1 Composition
하기 [표 1]에 기재된 바와 같이, 정제수, 비피두스엑스(전체 조성물에 대해 1000ppm), 레몬추출물, 모과추출물, 아스코르브산나트륨, 토코페롤아세테이트, 클로브 오일(CAS No. 8000-34-8), 로즈마리엑스(CAS No. 84604-14-8), 자일리톨(CAS No. 87-99-0), 효소처리스테비아, 산화아연(CAS No. 1314-13-2), 세틸피리디늄염화물(CAS No. 6004-24-6), 알로에베라겔, 프로폴리스추출물(CAS No. 85665-41-4), 로얄젤리추출물, 농글리세린(CAS No. 56-81-5), 구연산(CAS No. 5949-27-1), 탄산수소나트륨, 레몬민트향(제품명 HF-6381, 한빛향료사로부터 입수), 민트향(제품명 AH-F-2217, 한빛향료사로부터 입수), 하이드로제네이티드캐스터오일(CAS No. 61788-85-0), 소르빈산칼륨(CAS No. 24634-61-5)를 준비하였다.As shown in [Table 1] below, purified water, bifidus extract (1000 ppm for the total composition), lemon extract, quince extract, sodium ascorbate, tocopherol acetate, clove oil (CAS No. 8000-34-8), rosemary Extract (CAS No. 84604-14-8), xylitol (CAS No. 87-99-0), enzyme-treated stevia, zinc oxide (CAS No. 1314-13-2), cetylpyridinium chloride (CAS No. 6004) -24-6), aloe vera gel, propolis extract (CAS No. 85665-41-4), royal jelly extract, concentrated glycerin (CAS No. 56-81-5), citric acid (CAS No. 5949-27-1) ), sodium bicarbonate, lemon mint flavor (product name HF-6381, obtained from Hanbit Fragrance), mint flavor (product name AH-F-2217, obtained from Hanbit Fragrance), hydrogenated castor oil (CAS No. 61788- 85-0) and potassium sorbate (CAS No. 24634-61-5) were prepared.
상기 각 성분을 혼합탱크에 투입하고 용해하여 혼합물을 형성하였다. 상기 혼합물을 70 내지 80℃로 유지하며 2,800 내지 2,300RPM으로 60분 동안 교반하였다. 이후 교반을 종료하고 상기 교반된 혼합물을 20분 동안 천천히 40℃까지 냉각하였다. 냉각된 조성물이 물 중 균일하게 혼합되어 침전물이 없음을 확인한 다음 저장통에 배출하였다. 배출된 조성물을 50g으로 소분 계량하여 실시예 1 조성물로 준비하였다.Each of the above components was added to a mixing tank and dissolved to form a mixture. The mixture was maintained at 70 to 80°C and stirred at 2,800 to 2,300 RPM for 60 minutes. Afterwards, stirring was terminated and the stirred mixture was slowly cooled to 40°C for 20 minutes. After confirming that the cooled composition was uniformly mixed in water and that there was no precipitate, it was discharged into a storage tank. The discharged composition was weighed into 50g portions and prepared as the composition of Example 1.
비교 실시예 1 내지 4: 비교 조성물 1 내지 4의 제조Comparative Examples 1 to 4: Preparation of Comparative Compositions 1 to 4
하기 [표 1]에 기재된 바와 같이 각 성분을 계량하여 준비한 것을 제외하고는 상기 실시예 1에 기재된 제조 방법에 따라 비교 조성물 1 내지 4를 50g씩 소분 계량하여 준비하였다.Comparative compositions 1 to 4 were prepared in small portions of 50 g according to the manufacturing method described in Example 1, except that each component was measured and prepared as shown in [Table 1] below.
비교 실험예 1: 음식 섭취 후 구취평가Comparative Experiment Example 1: Bad breath evaluation after food intake
15세 내지 63세 남성 및 여성 실험자 40명을 무작위하게 선정하고, 김치찌개, 된장찌개, 돈까스, 제육볶음, 갈비탕, 감자탕, 오징어볶음으로 이루어진 군으로부터 선택된 1개의 음식 300g 및 쌀밥 200g을 일상식으로 무작위 선정하여 섭취시켰다. 이후 60분 간격으로 물 150ml를 섭취하도록 하여 300분간 대기시켰다. 이후 각 실험자의 날숨을 각각 포집하여 황화수소, 메틸메르캅탄 및 디메틸설파이드의 함량을 오랄크로마(CHM-2)를 사용하여 분석하였다.40 male and female subjects aged 15 to 63 were randomly selected and given 300g of one food selected from the group consisting of kimchi stew, soybean paste stew, pork cutlet, stir-fried pork, galbitang, gamjatang, and stir-fried squid, and 200g of rice as their daily diet. They were randomly selected and consumed. Afterwards, the subjects were allowed to drink 150ml of water every 60 minutes and waited for 300 minutes. Afterwards, each experimenter's exhaled breath was collected and the contents of hydrogen sulfide, methyl mercaptan, and dimethyl sulfide were analyzed using Oral Chroma (CHM-2).
상기 날숨이 포집된 실험자 각각에게 물 100ml를 제공하고 10초간 5회 가글하도록 하였다. 물에 의한 가글이 완료된 실험자들에게 실시예 1 조성물 및 비교 실시예 1 내지 4 조성물을 스프레이를 사용하여 구강 내에 3ml씩 3회 분사한 다음 유지시켰다. 5분 후 실험자의 날숨을 각각 포집하여 황화수소, 메틸메르캅탄 및 디메틸설파이드의 함량을 오랄크로마(CHM-2)를 사용하여 분석하였다. 5시간 후 동일하게 조성물을 구강 내에 분사한 다음 유지시켰다. 5분 후 실험자의 날숨을 각각 포집하여 황화수소, 메틸메르캅탄 및 디메틸설파이드의 함량을 오랄크로마(CHM-2)를 사용하여 분석하였다 분석결과를 비교하여 감소율을 %로 도출하였다. 결과를 [표 2] 내지 [표 6]에 도시하였다.Each experimenter whose exhaled breath was collected was provided with 100ml of water and asked to gargle 5 times for 10 seconds. After gargling with water was completed, the composition of Example 1 and the compositions of Comparative Examples 1 to 4 were sprayed into the oral cavity three times at 3 ml each using a spray and then maintained. After 5 minutes, each experimenter's exhaled breath was collected and the contents of hydrogen sulfide, methyl mercaptan, and dimethyl sulfide were analyzed using Oral Chroma (CHM-2). After 5 hours, the same composition was sprayed into the oral cavity and maintained. After 5 minutes, each experimenter's exhaled breath was collected and the contents of hydrogen sulfide, methyl mercaptan, and dimethyl sulfide were analyzed using Oral Chroma (CHM-2). The analysis results were compared to derive the reduction rate in %. The results are shown in [Table 2] to [Table 6].
비교 실험예 2: 흡연 후 구취평가Comparative Experimental Example 2: Bad breath evaluation after smoking
30세 내지 50세의 흡연자인 남성 및 여성 실험자 10명을 무작위하게 선정하고 연초 1개피를 흡연하게 하였다. 이후 3분간 양치를 수행시키고 60분 간격으로 물 500ml를 섭취하도록 하여 180분간 대기시켰다. 상기 대기한 실험자를 동일한 시각에 각각 연초 1개피를 흡연하게 하였다. 30분 후 각 실험자의 날숨을 포집하여 황화수소, 메틸메르캅탄 및 디메틸설파이드의 함량을 오랄크로마를 사용하여 분석하였다.Ten male and female smokers aged 30 to 50 were randomly selected and asked to smoke one cigarette. Afterwards, the subjects brushed their teeth for 3 minutes, drank 500ml of water every 60 minutes, and waited for 180 minutes. The waiting experimenters each smoked one cigarette at the same time. After 30 minutes, each experimenter's exhaled breath was collected and the contents of hydrogen sulfide, methyl mercaptan, and dimethyl sulfide were analyzed using Oralchroma.
상기 날숨이 포집된 실험자 각각에게 물 100ml를 제공하고 5회 가글하도록 하였다. 물에 의한 가글이 완료된 실험자들에게 실시예 1 조성물 및 비교 실시예 1 내지 4 조성물을 스프레이를 사용하여 구강 내에 3ml씩 3회 분사한 다음 유지시켰다. 5분 후 각 실험자들의 날숨을 포집하여 황화수소, 메틸메르캅탄 및 디메틸설파이드의 함량을 오랄크로마를 사용하여 분석하였다. 분석결과를 비교하여 감소율을 %로 도출하였다. 결과를 [표 2] 내지 [표 6]에 도시하였다.Each experimenter whose exhaled breath was collected was provided with 100ml of water and asked to gargle 5 times. After gargling with water was completed, the composition of Example 1 and the compositions of Comparative Examples 1 to 4 were sprayed into the oral cavity three times at 3 ml each using a spray and then maintained. After 5 minutes, each experimenter's exhaled breath was collected and the contents of hydrogen sulfide, methyl mercaptan, and dimethyl sulfide were analyzed using Oralchroma. By comparing the analysis results, the reduction rate was derived as a percentage. The results are shown in [Table 2] to [Table 6].
비교 실험예 3: 기상 후 구취평가Comparative Experimental Example 3: Bad breath evaluation after waking up
30세 내지 50세의 비흡연자인 남성 및 여성 실험자 10명을 무작위하게 선정하고 D-1일 23:00 취침하도록 하고 D+0일 7시에 기상시킨 다음 기상 직후 날숨을 포집하여 황화수소, 메틸메르캅탄 및 디메틸설파이드의 함량을 오랄크로마를 사용하여 분석하였다.Ten male and female experimenters who were 30 to 50 years old and non-smokers were randomly selected. They were asked to go to bed at 23:00 on D-1 and woke up at 7:00 on D+0. Their exhaled breath was collected immediately after waking up and exposed to hydrogen sulfide and methyl mer. The contents of captan and dimethyl sulfide were analyzed using Oralchroma.
상기 날숨이 포집된 실험자 각각에게 물 100ml를 제공하고 5회 가글하도록 하였다. 물에 의한 가글이 완료된 실험자들에게 실시예 1 조성물 및 비교 실시예 1 내지 4 조성물을 스프레이를 사용하여 구강 내에 3ml씩 3회 분사한 다음 유지시켰다. 이후 각 실험자들의 날숨을 포집하여 황화수소, 메틸메르캅탄 및 디메틸설파이드의 함량을 오랄크로마를 사용하여 분석하였다. 분석결과를 비교하여 감소율을 %로 도출하였다. 결과를 [표 2] 내지 [표 6]에 도시하였다.Each experimenter whose exhaled breath was collected was provided with 100ml of water and asked to gargle 5 times. After gargling with water was completed, the compositions of Example 1 and Comparative Examples 1 to 4 were sprayed into the oral cavity three times at 3 ml each using a spray and then maintained. Afterwards, the exhaled breath of each experimenter was collected and the contents of hydrogen sulfide, methyl mercaptan, and dimethyl sulfide were analyzed using Oralchroma. By comparing the analysis results, the reduction rate was derived as a percentage. The results are shown in [Table 2] to [Table 6].
상기 [표 2] 내지 [표 6]에서 확인되는 바와 같이, 본 발명에 따른 실시예 1 조성물은 비교예 1 내지 4 조성물에 비해 우수한 구취 유발 기체 제거 효과를 나타내는 것으로 확인되어, 본 발명에 따른 조성물의 구성, 및 각 성분의 함량 및 그 비율이 본 발명에 따른 조성물에 우수한 효능을 부여하는 것으로 확인되었다.As confirmed in [Table 2] to [Table 6], the composition of Example 1 according to the present invention was confirmed to exhibit an excellent effect of removing bad breath-causing gases compared to the compositions of Comparative Examples 1 to 4, and the composition according to the present invention It was confirmed that the composition, and the content and ratio of each component provide excellent efficacy to the composition according to the present invention.
비교 실험예 4: 항균평가Comparative Experimental Example 4: Antibacterial Evaluation
실시예 1 조성물을 외용소독제(의약외품) 효력평가법 가이드라인(식품의약품안전평가원, 2014)에 따라 항균력을 평가하였다. 균수를 조정한 균액을 시험구와 대조구(펩톤수)에 첨가한 후 10초간 격렬하게 교반시킨 후 실온에서 30분 방치하였다. 이후 13000rpm으로 2분간 원심분리하여 상등액을 제거한 후 PBS를 첨가하여 2회 세척하였다. 이후 원액을 단계적으로 희석하여 배지에 접종하고 CFU를 계수하여 균 감소율(%)을 [(접종수-시간 경과 후 균수)/접종수] x 100으로 측정하였다. 노출시간은 30분이었다. 결과를 [표 7]에 도시하였다.Example 1 The antibacterial activity of the composition was evaluated according to the guidelines for efficacy evaluation of external disinfectants (quasi-drugs) (Korea Food and Drug Safety Evaluation Institute, 2014). The bacterial solution with the adjusted number of bacteria was added to the test group and the control group (peptone water), stirred vigorously for 10 seconds, and left at room temperature for 30 minutes. Afterwards, the supernatant was removed by centrifugation at 13000 rpm for 2 minutes, and then washed twice by adding PBS. Afterwards, the stock solution was diluted step by step and inoculated into the medium, CFU was counted, and the bacterial reduction rate (%) was measured as [(number of inoculums - number of bacteria after time)/number of inoculum] x 100. Exposure time was 30 minutes. The results are shown in [Table 7].
ATCC 25586(균주 1)ATCC 25586 (strain 1)
ATCC 25611(균주 2)ATCC 25611 (strain 2)
ATCC 33277(균주 3)ATCC 33277 (strain 3)
ATCC 43037(균주 1)ATCC 43037 (strain 1)
각 균주는 37도씨에서 배양되었고, Anaerobic 에서 대기되었으며, 균주 1 및 2는 4일간, 균주 3은 15일간, 균주 4는 11일간 배양되었다. 균주 1의 배지는 RF, 균주 2 및 3의 배지는 5% Blood TSA + H/M, 균주 4의 배지는 NAM medium이었다.Each strain was cultured at 37 degrees Celsius and stored in Anaerobic. Strains 1 and 2 were cultured for 4 days, strain 3 for 15 days, and strain 4 for 11 days. The medium for strain 1 was RF, the medium for strains 2 and 3 was 5% Blood TSA + H/M, and the medium for strain 4 was NAM medium.
상기 [표 7] 에서 확인되는 바와 같이, 본 발명에 따른 실시예 1 조성물은 우수한 항균 내지는 살균 효과를 나타내는 것으로 확인되어, 본 발명에 따른 조성물의 구성, 및 각 성분의 함량 및 그 비율이 본 발명에 따른 조성물에 우수한 효능을 부여하는 것으로 확인되었다.As confirmed in [Table 7], the composition of Example 1 according to the present invention was confirmed to exhibit excellent antibacterial or bactericidal effects, and the composition of the composition according to the present invention and the content and ratio of each component are as described in the present invention. It was confirmed that it gave excellent efficacy to the composition according to.
이상에서 본 발명의 바람직한 실시예들에 대하여 상세하게 설명하였지만 본 발명의 권리 범위는 이에 한정되는 것은 아니고 다음의 청구범위에서 정의하고 있는 본 발명의 기본 개념을 이용한 당업자의 여러 변형 및 개량 형태 또한 본 발명의 권리범위에 속하는 것이다.Although the preferred embodiments of the present invention have been described in detail above, the scope of the present invention is not limited thereto, and various modifications and improvements can be made by those skilled in the art using the basic concept of the present invention defined in the following claims. It falls within the scope of invention rights.
Claims (8)
상기 비피두스엑스는, 전체 조성물을 기준으로 500 내지 1500ppm으로 포함되고,
상기 클로브 오일 및 상기 로즈마리엑스는 각 성분의 중량을 기준으로 (2.5~3.5):(1.5~0.5)의 비율로 포함되는, 구강용 액상 조성물.Contains bifidus extract, clove oil, rosemary extract, zinc oxide, cetylpyridinium chloride, vitamin C, vitamin E, lemon extract and quince extract,
The Bifidus Ex is contained at 500 to 1500 ppm based on the total composition,
The clove oil and the rosemary extract are included in a ratio of (2.5 to 3.5):(1.5 to 0.5) based on the weight of each component.
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| PCT/KR2023/015777 WO2025005348A1 (en) | 2023-06-26 | 2023-10-12 | Oral liquid composition comprising bifidobacterium extract |
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| KR20160090708A (en) * | 2015-01-22 | 2016-08-01 | 조선대학교산학협력단 | Composition for mouth comprising camellia japonica l leaf extract and manufacturing method thereof |
| KR20180053405A (en) | 2015-11-18 | 2018-05-21 | 가부시키가이샤 상기 | Oral composition |
| KR20210097298A (en) * | 2020-01-30 | 2021-08-09 | 동아대학교 산학협력단 | Oral spray composition for removing halitosis or preventing oral disease and its preparing method |
| KR102383734B1 (en) | 2020-02-28 | 2022-04-07 | 주식회사 바른 | Ingestible Tablet or Powder Type Oral Cleaning Composition |
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