KR102469323B1 - Liquid composition for gargle containing clove oil - Google Patents

Abstract

Provided is a liquid composition for gargling containing clove oil, rosemary oil, cetylpyridinium chloride and zinc oxide. The liquid composition for gargling of the present invention has significantly improved portability and economic feasibility compared to liquid composition products for gargling conventionally distributed and sold in a diluted state.

Description

Liquid composition for gargling containing clove oil {LIQUID COMPOSITION FOR GARGLE CONTAINING CLOVE OIL}

The present invention relates to a liquid composition for gargling, and more particularly, to a concentrated liquid composition for gargling containing clove oil, and more particularly, to a gargle containing clove oil, rosemary oil, cetylpyridinium chloride and zinc oxide. It relates to a concentrated liquid composition for

BACKGROUND OF THE INVENTION [0002] The oral cavity is an entrance to the digestive and respiratory organs, and is composed of mucous membranes and is an organ in which the tongue, gums, teeth, and salivary glands are arranged. When food is introduced into the oral cavity, the food is pulverized through mastication, saliva secreted from the salivary gland is mixed with the pulverized food, and then the mixture moves to the esophagus after being connected to the oral cavity. In the oral environment where these functions are performed, residual debris generated after ingestion of various foods may not be completely removed, and as a result, it is exposed to negative changes such as bad breath, plaque formation, tooth decay, gum disease, pigmentation, and the like.

Bad breath is an unpleasant odor caused by the decay of food residues or the metabolism of food residues by bacteria and fungi in the mouth as food residues are present in the oral cavity. In the case of eating the same food, strong bad breath may occur due to a specific ingredient unique to the food, or the time required for the process of naturally suppressing bad breath due to secretions such as saliva in the mouth may increase, In general, sulfur-containing gases, typically hydrogen sulfide (H ₂ S), methyl mercaptan (CH ₃ SH), and dimethyl sulfide (CH ₃ SCH ₃ ), are widely known as bad breath-inducing gases.

In order to prevent or suppress the problems related to oral hygiene as described above, it is common and recommended to hygienically manage the oral environment by removing residual food and plaque in the oral cavity through brushing with a toothbrush and toothpaste. Toothpaste typically contains a surfactant and an abrasive, and is used by a toothbrush, which is a physical cleaning tool, to perform a function of removing food and other plaques remaining in the oral cavity, in particular, adhered to teeth.

In addition, toothpastes containing various active ingredients such as fluoride and calculus removers have been developed to effectively control factors that negatively affect oral hygiene. However, brushing with a toothbrush and toothpaste that is commonly available may not be sufficient to hygienically change the oral environment to a desired level depending on the shape of the toothbrush, and to overcome this problem, an interdental toothbrush, Oral hygiene management through a liquid composition for flossing and/or gargling has been proposed.

Interdental brushes and dental floss are known to be effective in removing food remnants and the like located in spaces between teeth where a toothbrush cannot reach. However, oral hygiene management through interdental brushes and dental floss is limited in that it is generally performed after brushing teeth with a toothbrush, and there are temporal and spatial limitations for using the interdental brushes and dental floss.

Oral hygiene management through the liquid composition for gargling is, after brushing teeth with a toothbrush and toothpaste, after oral care using an interdental brush and / or dental floss, the toothbrush, interdental brush and / or dental floss can not reach the debris remaining in the oral space It is widely known as an effective means to remove or remove harmful germs or components that cause tooth decay, bad breath, and other oral diseases. Gargling is generally performed by keeping the liquid composition for gargling in the oral cavity and circulating it based on the fact that the composition for gargling is a liquid composition, and a liquid composition for gargling is provided for this purpose.

The liquid composition for gargling generally contains water, ethanol, antibacterial ingredients, and other various active ingredients for improving oral hygiene, and the water content in order to stably secure the advantages of the liquid composition for gargling based on the characteristics of liquid has this high quality.

For the above-described desirable oral hygiene management, after oral care using a toothbrush, toothpaste, interdental brush, and/or floss, a gargling step is required to remove remaining food and other microscopic contaminants. The step-by-step oral hygiene management as described above is usually performed after waking up in the morning and after breakfast for general modern people, and oral hygiene management is performed after meals or as needed in daily life.

However, despite the advantages provided by oral hygiene management through gargling, due to the nature of the liquid composition for gargling having a high water content, the volume of the liquid composition for sufficiently performing the gargling step is relatively large compared to, for example, toothpaste There are problems with being large and heavy. This is a major factor that makes the portability of the liquid composition for gargling low, especially compared to the portability of a toothbrush and toothpaste. This practically is required almost every day, and in certain cases, a situation in which gargling cannot be performed may also occur as supplementation is not made.

In addition, although a generally provided liquid composition for gargling uses a gargling method in which a certain amount of the composition is used for a certain period of time, gargling according to the gargling method according to the user's oral environment may It can provide more than necessary stimulation to the oral cavity of the user, which can negatively affect the user's oral environment, and when the user's oral environment is poor, the gargling method can provide sufficient mouth freshness and the effect of preventing tooth decay and various gum diseases. There are also cases where it cannot be obtained.

In addition, even when the gargling step is performed using the liquid composition for gargling, the conventional liquid composition for gargling performs the function of removing various contaminants through the fluid flow formed by the liquid composition in the oral cavity, that is, by physical means. In addition, based on the function of various active ingredients included in the composition, it provides the effect of refreshing the oral cavity and improving oral health, but conventionally used essential oil, cetylpyridinium chloride, fluorine and other active ingredients having similar purposes and functions There is also a problem that the effect of improving oral health and oral health is not sufficient.

Therefore, by maximizing the beneficial effects of the active ingredients contained in the liquid composition for gargling, the function of removing and suppressing harmful factors such as bacteria and fungi in the oral cavity, which is improved compared to the conventional liquid composition for gargling, and the user's bad breath removal A liquid composition for gargling that performs the function is required.

Furthermore, as the liquid composition for gargling as described above is provided as a concentrated liquid composition for gargling, the concentration of the active ingredient contained in the liquid composition for gargling is diluted to suit the user. The liquid composition for gargling is easily obtained by the user Based on this, there is a need for a liquid composition for gargling that can respond variably according to the oral environment of modern people, which is changed by various factors.

The present invention provides a liquid composition for gargling containing zinc oxide and cetylpyridinium chloride, and a liquid composition for gargling containing clove oil and rosemary oil in order to solve the problems of the conventional liquid composition for gargling described above. In particular, it provides a liquid composition for gargling containing the clove oil and the rosemary oil in a ratio of 3:1 based on the weight of each component.

In addition, the present invention provides a liquid composition for gargling in order to solve the problems of the conventional liquid composition for gargling. More specifically, while providing a concentrated liquid composition for gargling with a drastically reduced water content, the user can mix the concentrated liquid composition for gargling with water to obtain a liquid composition for gargling, and special in the mixing Provided is a concentrated liquid composition for gargling that is quickly and easily mixed with water so that no equipment or means are required.

The inventors of the present invention have found that the liquid composition for gargling containing clove oil and rosemary oil according to the present invention has an effect of removing bad breath and refreshing the mouth, and in particular, the clove oil and the rosemary oil have the weight of each component It was found that the liquid composition for gargling included in a ratio of 3: 1 based on has an excellent effect on removing bad breath.

In addition, the inventors of the present invention found that the liquid composition for gargling containing cetylpyridinium chloride and zinc oxide according to the present invention has an effect of removing bad breath and refreshing the mouth, and in particular, the liquid composition for gargling contains clove oil And rosemary oil was found to have a more excellent bad breath removal and mouth freshening effect, and furthermore, the clove oil and the rosemary oil were included in a ratio of 3: 1 based on the weight of each component. It was found that the solution composition had an excellent effect on removing bad breath.

In addition, as the inventors of the present invention provide the liquid composition for gargling as a concentrated liquid composition for gargling, the user can mix a certain amount of the concentrated liquid composition for gargling with water to easily obtain a diluted liquid composition for gargling It can be obtained, and by directly adjusting the concentration of the active ingredient in the diluted liquid composition for gargling by the user, a diluted liquid composition for gargling of low concentration or high concentration is obtained as necessary, and conventionally diluted through use. It was found that it is possible to provide a liquid composition product for gargle with significantly improved portability and economy compared to liquid composition products for gargle distributed and sold.

1 is a flowchart schematically showing each step of preparing a liquid composition for gargling according to the present invention.

The technical terms used in the present invention are only used to describe the following embodiments, and are not intended to limit the scope of the present invention through the technical terms, and the technical terms are specifically used in the present invention. Unless the meaning is defined, it should be understood to convey the meaning commonly understood and used by a person skilled in the art (hereinafter referred to as "ordinary skill") to which the present invention belongs.

The present invention is not limitedly embodied by the means or forms described in this specification, and is easily substituted or modified by those skilled in the art within the principle of solving the technical problem to be solved by the present invention. It may be substituted or changed in a possible configuration, and it should be understood that a person skilled in the art can clearly recognize it based on the details described in this specification.

As used herein, the term 'and/or' is a term that includes each and every combination of one or more of the recited items. In addition, singular terms also include plural unless otherwise stated.

The terms 'comprising' and/or 'comprising' used in this specification are terms that do not exclude the presence or addition of other items other than the mentioned items.

In this specification, a numerical range expressed using the term 'to' indicates a numerical range including the values described before and after the term as the lower limit value and the upper limit value, respectively. When a plurality of numerical values are disclosed as the upper and lower limits of any numerical range, the numerical range disclosed in this specification includes any one of the plurality of lower limits and any one of the plurality of upper values, respectively. It can be understood as any numerical range with a lower limit and an upper limit.

As used herein, the terms 'about' or 'approximately', when used, mean a value or range of values that is within 10% of the value or range of values stated following the term.

Hereinafter, the present invention will be described in detail using the following examples.

In one embodiment of the present invention, the liquid composition for gargling according to the present invention is purified water; cetylpyridinium chloride; zinc oxide; concentrated glycerin; citric acid; sodium chloride; potassium sorbate; hydrogenated castor oil; sweetening agent; And it may be a concentrated liquid composition for gargling containing a flavoring agent.

In one embodiment of the present invention, the cetylpyridinium chloride contained in the liquid composition for gargling is 1.0 to 5.0% by weight, preferably 1.5 to 4.0% by weight, more preferably 2.0% by weight based on the weight of the total composition to 3.0% by weight, more preferably 2.1 to 2.5% by weight, and most preferably 2.2 to 2.4% by weight.

In one embodiment of the present invention, the sweetener included in the liquid composition for gargling may be a sweetener selected from the group including xylitol, sodium saccharin, various other sweeteners for improving the taste of the composition, and combinations thereof.

In one embodiment of the present invention, the flavoring agent included in the liquid composition for gargling may be a flavoring agent composed of a functional flavoring agent and a non-functional flavoring agent, and the functional flavoring agent is L-menthol, citron extract, or rosemary oil. It may be a flavoring agent selected from the group comprising rosemary extract, propolis extract, clove oil, and combinations thereof, and the non-functional flavoring agent may be red wine flavor, mint flavor, herb mint flavor, and various other flavors for adding flavor to the composition. It may be a flavoring agent selected from the group comprising non-functional flavoring agents and combinations thereof.

In a preferred embodiment of the present invention, the flavoring agent included in the liquid composition for gargling may be a flavoring agent composed of a functional flavoring agent and a non-functional flavoring agent, and the functional flavoring agent is L-menthol, citron extract, rosemary oil It may be a functional flavoring agent composed of rosemary extract, propolis extract, and clove oil, and the non-functional flavoring agent may be a non-functional flavoring agent composed of red wine extract, mint flavor, and herb mint flavor as red wine flavor.

In a preferred embodiment of the present invention, the flavoring agent included in the liquid composition for gargling may be a flavoring agent composed of a functional flavoring agent and a non-functional flavoring agent, and the functional flavoring agent is L-menthol, citron extract, rosemary oil As may be a functional flavoring agent consisting of rosemary extract, propolis extract and clove oil, in particular, the clove oil and the rosemary extract may be included in a ratio of 3: 1 based on the weight of each component.

The clove oil is a kind of essential oil extracted from the clove tree, has a light yellow color, and is an antibacterial agent with excellent sterilizing effect against bacteria. It is a component and is known to be an effective component in preventing tooth decay.

The rosemary oil or rosemary extract plays a role in inhibiting the growth of bacteria and fungi, can be used as a mild analgesic if necessary, and is a component known to have a preventive effect of circulatory disorders and a vasodilator effect due to increased circulation. .

The propolis or propolis extract is a component widely known to perform naturally-derived antibacterial, antifungal, antiviral and antioxidant functions, inhibiting the growth of bacteria and/or bacteria in the oral cavity and having an excellent effect on removing bad breath. It is known as a component having a preventive effect on gum disease and removal and suppression of bacteria causing tooth decay, and contains vitamins A, B, E, and/or flavonoids, and the contained flavonoid components cause bad breath. It is an ingredient known to relieve bad breath by attacking

The xylitol is a naturally-derived ingredient obtained from birch trees, and is known as a component that has a sweet taste and prevents various bacteria in the oral cavity that generate energy by ingesting sugar to eliminate energy.

The citron extract is a flavoring agent, a natural preservative extracted from yuzu, a non-toxic and non-metallic natural antibacterial agent, and a component that performs the function of supplying vitamin C and antioxidant function to prevent rancidity of fat. .

The red wine extract has anti-inflammatory and / or antibacterial effects, and is a component that performs an antioxidant function by the polyphenol component contained in the red wine extract, and may be a functional flavoring agent or a non-functional flavoring agent depending on the content. .

The zinc oxide performs the function of collecting bad breath gas that conveys bad breath, performs the function of removing bacteria that cause bad breath, has anti-inflammatory and / or antibacterial effects, inhibits and controls the formation of plaque in the oral cavity, , It is a component that suppresses the formation of calculus in the oral cavity, suppresses demineralization of the enamel constituting the tooth surface in the oral cavity and provides an effect of remineralization, suppresses and improves gum bleeding in the oral cavity, and improves immunity. It is known as a component that performs

The concentrated glycerin, as a humectant, is a component known to have a moisturizing effect and a moisture imparting effect by performing a function of suppressing the escape of moisture in the oral cavity, and the sodium chloride has an antibacterial effect, a gum disease preventive effect, and / or healing of oral ulcers It is a component known to perform the function of promoting.

Hereinafter, the present invention will be described in more detail using the following examples.

Example 1 : Preparation of the composition of Example 1

As described in Table 1 below, 865.7 g of purified water, cetylpyridinium chloride (CAS No. 6004-24-6), 22.96 g, zinc oxide (CAS No. 1314-13-2) 0.01 g, concentrated glycerin ( CAS No. 56-81-5) 50.0 g, citric acid (CAS No. 5949-27-1) 1.0 g, sodium chloride (CAS No. 7647-14-5) 1.0 g, potassium sorbate (CAS No. 24634-61- 5) 3.0g, Hydrogenated Castor Oil (CAS No. 61788-85-0) 40.0g, Xylitol (CAS No. 87-99-0) 2.0g, Saccharin Sodium (CAS No. 6155-57-3) 10.0 g, L-menthol (CAS No. 2216-51-5) 0.2g, red wine flavor (product name HF-6267, obtained from Hanbit Fragrance Co.) 0.2g, mint flavor (product name AH-F-2217, obtained from Hanbit Fragrance Co., Ltd.) Obtained) 0.2g, herb mint flavor (product name HF-6381, obtained from Hanbit Fragrance Co.) 0.4g, clove oil (CAS No. 8000-34-8) 1.0g, citron extract (product name Yuzunos, obtained from Biospectrum) ) 0.1 g, rosemary extract (CAS No. 84604-14-8) 0.3 g, and propolis extract (CAS No. 85665-41-4) 1.0 g were prepared by weighing.

Each of the above components was put into a mixing tank and dissolved to form a mixture. The mixture was stirred at 2,800 to 2,300 RPM for 60 minutes while maintaining at 70 to 80 °C. Then, stirring was terminated and the stirred mixture was slowly cooled to 40° C. for 20 minutes. After confirming that the cooled composition was uniformly mixed in water and there was no precipitate, it was discharged into a storage container. The discharged composition was weighed in small portions of 50 g to prepare the composition of Example 1.

Comparative Examples 1 to 7 : Preparation of Comparative Compositions 1 to 7

Comparative Compositions 1 to 7 were prepared by weighing 50 g each in subdivisions according to the manufacturing method described in Example 1, except that each component was prepared by weighing as described in <Table 1> and <Table 2> below.

<Table 1>

<Table 2>

Comparative Experimental Example 1 : Assessment of bad breath inhibition after garlic intake

40 male and female experimenters between the ages of 15 and 63 were randomly selected, and 300 g of one food selected from the group consisting of kimchi stew, soybean paste stew, pork cutlet, stir-fried pork cutlet, galbitang, gamjatang, and stir-fried squid was served as daily food. They were randomly selected and consumed. Thereafter, brushing was performed for 3 minutes, and 500 ml of water was consumed at intervals of 60 minutes to wait for 180 minutes.

The waiting experimenters were randomly divided into 8 groups of 5 people each, and each ingested 5 cloves of garlic at the same time. After 20 minutes, the exhaled breath of the experimenter who ingested the garlic was collected, and the contents of hydrogen sulfide, methyl mercaptan, and dimethyl sulfide, which are gases that cause bad breath, were analyzed using OralChroma (CHM-2). The results are shown in <Table 3>.

100 ml of water was provided to each of the experimenters whose exhaled breath was collected and gargled 5 times. After gargling with water was completed, 30 ml of the composition of Example 1 and Comparative Examples 1 to 7 diluted 10 times was provided to the experimenters to gargle for 30 seconds and gargle with 100 ml of water for 10 seconds. The exhaled breath of the experimenter after gargling was completed was collected and the contents of hydrogen sulfide, methyl mercaptan, and dimethyl sulfide were analyzed using Oral Chroma (CHM-2). The results are shown in <Table 3>.

Comparative Experimental Example 2 : Assessment of bad breath inhibition after daily meal intake

On the day after the measurement according to Comparative Experimental Example 1, 40 male and female experimenters aged 15 to 63 randomly selected in Comparative Experimental Example 1 were subjected to kimchi stew, soybean paste stew, pork cutlet, stir-fried pork ribs, galbitang, and potato soup , 300 g of one food selected from the group consisting of stir-fried squid and 200 g of rice were randomly selected and consumed as daily meals. Thereafter, brushing was performed for 3 minutes, and 500 ml of water was consumed at intervals of 60 minutes to wait for 180 minutes.

The waiting experimenters were randomly divided into 8 groups of 5 people each, and at the same time, 300 g of one food selected from the group consisting of kimchi stew, soybean paste stew, pork cutlet, pork stir-fry, galbitang, gamjatang, and stir-fried squid was served with 200 g of rice. They were randomly selected and ingested with common sense. After 20 minutes, the exhaled breath of the experimenter who consumed the daily diet was collected, and the contents of hydrogen sulfide, methyl mercaptan, and dimethyl sulfide were analyzed using Oral Chroma (CHM-2). The results are shown in <Table 4>.

100 ml of water was provided to each of the experimenters whose exhaled breath was collected and gargled 5 times. After gargling with water, 30 ml of the composition of Example 1 and Comparative Examples 1 to 7 diluted 10 times was provided to the experimenters who had completed gargling with water, and gargled first for 30 seconds and gargled with 100 ml of water for 10 seconds. The exhaled breath of the experimenter after gargling was completed was collected and the contents of hydrogen sulfide, methyl mercaptan, and dimethyl sulfide were analyzed using Oral Chroma (CHM-2). The results are shown in <Table 4>.

Four people from each group of experimenters who completed the first gargling with Comparative Compositions 1 to 3 were randomly selected, and then, 2 of the groups that first gargled with Comparative Composition 1 were designated as A1 and the other two as B1, and the same The groups gargled first with Comparative Compositions 2 and 3 were divided into 6 groups, A2, A3, B2 and B3, and waited for 60 minutes. Groups A1 to A3 were gargled with 30 ml of the composition according to Example 1 diluted 10 times for 30 seconds and gargled with 100 ml of water for 10 seconds. Groups B1 to B3 were gargled with 30 ml of the same composition as the first gargle for 30 seconds and gargled with 100 ml of water for 10 seconds. The exhaled breath of the experimenter after gargling was completed was collected and the contents of hydrogen sulfide, methyl mercaptan, and dimethyl sulfide were analyzed using Oral Chroma (CHM-2). The results are shown in <Table 5>.

<Table 3>

<Table 4>

<Table 5>

Based on the 40 experimenters, the cognitive limit values measured for each of hydrogen sulfide, methyl mercaptan, and dimethyl sulfide were measured, and then the respective averages were derived as 112 ppb, 26 ppb, and 8 ppb.

According to the experimental results, the concentrations of hydrogen sulfide, methyl mercaptan, and dimethyl sulfide contained in the exhaled breath of the experimenter who gargled with the composition diluted with the composition of Example 1 were compared to before gargling when garlic was consumed and daily food was consumed. significantly decreased, it was confirmed that the composition of Example 1 had excellent efficacy in removing bad breath.

In addition, according to the experimental results, compared to the composition of Example 1, hydrogen sulfide, methyl The concentrations of mercaptan and dimethyl sulfide were decreased compared to before gargling, but decreased to a significantly smaller extent compared to the case of using the composition of Example 1 and Comparative Examples 2 to 7, confirming that the effect of removing bad breath was poor.

In addition, according to the experimental results, the concentrations of hydrogen sulfide, methyl mercaptan and dimethyl sulfide contained in the exhaled breath of the experimenter who gargled with a diluted composition of Comparative Composition 2 without clove oil and rosemary extract compared to the composition of Example 1 were gargle Although it was reduced compared to before, it was reduced to a small extent compared to the case of using the composition of Example 1, and it was confirmed that the effect of removing bad breath was not sufficient, and compared to the composition of Example 1, cetylpyridinium chloride and zinc oxide were absent. The concentration of the gas contained in the exhaled breath of the experimenter who gargled with a composition diluted with Comparative Composition 3 was reduced compared to before gargling, but decreased to a small extent compared to the case of using the composition of Example 1, so the effect of removing bad breath was not sufficient. It was confirmed that no

In addition, according to the experimental results, the concentrations of hydrogen sulfide, methyl mercaptan, and dimethyl sulfide contained in the exhaled breath of the experimenter who gargled with a diluted composition of Comparative Composition 4 without zinc oxide compared to the composition of Example 1 were compared with before gargling. However, it was observed that it was reduced to a small extent compared to the case of using the composition of Example 1 and to a large extent compared to the case of using Comparative Composition 3, and compared to the composition of Example 1, cetylpyridinium chloride was absent. The concentration of the gas contained in the exhaled breath of the experimenter who gargled with a composition diluted with Comparative Composition 5 was reduced compared to before gargling, but decreased to a small extent compared to the case of using the composition of Example 1, and in the case of using Comparative Composition 3 It was observed that the liquid composition for gargling containing cetylpyridinium chloride and zinc oxide had an excellent effect on removing bad breath compared to the liquid composition for gargling containing cetylpyridinium chloride or zinc oxide. .

In addition, according to the experimental results, compared to the composition of Example 1, clove oil and rosemary extract were diluted with a composition diluted with comparative composition 6 containing clove oil and rosemary extract in a ratio of 1: 1 based on the weight of the clove oil and rosemary extract. The concentrations of hydrogen sulfide, methyl mercaptan, and dimethyl sulfide contained in the exhaled breath were reduced compared to before gargling, but decreased to a small extent compared to the case of using the composition of Example 1, and significantly reduced compared to the case of using Comparative Composition 1 It was observed that, compared to the composition of Example 1, clove oil and rosemary extract were gargled with a composition diluted with comparative composition 6 containing the clove oil and rosemary extract in a ratio of 5: 1 based on the weight of the clove oil and rosemary extract. The concentration of the gas contained in the exhaled breath was reduced compared to before gargling, but decreased to a small extent compared to the case of using the composition of Example 1, and significantly decreased compared to the case of using Comparative Compositions 1 and 6. Observed , It was confirmed that the bad breath removal effect was the best when the composition ratio of clove oil and rosemary oil included in the liquid composition for gargling was 3:1 based on the weight of each ingredient.

In addition, according to the experimental results, as a result of performing the second gargling on the experimenters who first gargled with Comparative Compositions 1 to 3, the concentrations of hydrogen sulfide, methyl mercaptan, and dimethyl sulfide contained in the experimenter's exhaled breath were generally lower than before gargling. However, in the case of the A1 to A3 groups gargled with the liquid composition for gargling diluted with the composition of Example 1, a significant decrease was observed compared to the case of the B1 to B3 groups using Comparative Compositions 1 to 3, especially in comparison In the case of B1 to B3 groups using Compositions 1 to 3, compared to the case of the first gargling using the composition of Example 1, the decrease was smaller compared to before gargling, and in the case of dimethyl sulfide, the second gargling was completed B1 and B3 It was observed that the cognitive limit value was exceeded in the group, and it was confirmed that cetylpyridinium, zinc oxide, clove oil, and rosemary oil included in the liquid composition for gargling had excellent effects on removing bad breath.

Claims (6)

A liquid composition for gargling containing purified water, clove oil, rosemary oil, xylitol, sodium saccharin, propolis extract, hydrogenated castor oil, citron extract, cetylpyridinium chloride and zinc oxide,
The clove oil and the rosemary oil are included in a ratio of 3:1 based on the weight of each component;
The xylitol is included in 0.2% by weight based on the weight of the total composition;
The saccharin sodium is included in 1.0% by weight based on the weight of the total composition;
The propolis extract is included in 0.1% by weight based on the weight of the total composition;
The hydrogenated castor oil is included in 4.0% by weight based on the weight of the total composition;
The citron extract is included in 0.1% by weight based on the weight of the total composition;
The cetylpyridinium chloride is included in 1.0 to 5.0% by weight based on the weight of the total composition;
The zinc oxide is included in 0.001% by weight based on the weight of the total composition,
A liquid composition for gargling. According to claim 1,
The liquid composition for gargling further comprises concentrated glycerin, citric acid, sodium chloride, and potassium sorbate,
The sodium chloride is included in 0.1% by weight based on the weight of the total composition;
The potassium sorbate is contained in 0.3% by weight based on the weight of the total composition,
A liquid composition for gargling. delete delete delete delete

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