KR20100134913A - Functional toothpaste composition for removal of oral odor - Google Patents

Abstract

PURPOSE: A functional toothpaste composition for removing bad breath containing Yuzu and Artemisia Princeps extract is provided to suppress methyl mercaptan without side effect to human body. CONSTITUTION: A functional toothpaste composition for removing bad breath contains Yuzu and Artemisia Princeps extract isolated from Artemisia keiskeana, seashore wormwood, Tarragon(Artemisia iwayomogi Kitamura, artemisiae capillaries herba), santonin wormwood, silk wormwood, and Artemisia Scoparia. The content of Yuzu and Artemisia Princeps extract is 0.005~5.0 weight% and 0.01~2.0 weight% each. The toothpaste composition further contains polishing agent having 2-20 weight% of hydrous silicon dioxide and/or 2-40 weight% of precipitated calcium carbonate and 10-70 weight% of wetting agent containing D-sorbitol liquid, concentrated glycerin, propylene glycol or PEG-75.

Description

Functional Toothpaste Composition for Removal of Oral Odor

The present invention relates to a functional toothpaste composition for removing bad breath containing citron extract and mugwort extract, and more specifically, by using an extract extracted from one or two or more of the mugwort of Yuzawa and various species of mugwort. It has an excellent inhibitory effect on methylmercaptan and is a natural ingredient, so it is related to a functional toothpaste composition that is environmentally friendly and has no side effects on the human body.

In general, bad breath is caused by acquired systemic diseases, or by decomposing enzymes or amino enzymes in amino acids produced by decomposition of proteins and food residues in saliva by microorganisms to produce odor-inducing substances. Among them, bad breath caused by decomposition of sulfides contained in substances such as garlic and red pepper is known to be very disgusting.

Representative constituents of bad breath include volatile sulfides (Volatile Sulfide Compounds; hereinafter abbreviated as VSC). These volatile sulfides include hydrogen sulfide (H2S), methyl mercaptan (CH3SH), and dimethyl. Dimethyl mercaptan (CH3) 2S], and in particular methylmercaptan is known as the main component of the disgusting smell during bad breath. In addition, in the case of fish, as the freshness decreases, trimethylamine (CH3) 3N or δ-aminovaleric acid, which is fishy fishy fish, is formed, and these volatile amine compounds, in particular, trimethylamine It forms a major part of this odor component. Other bad breath causing agents include aldehydes, fatty acids, ammonia or pyridine.

Conventionally, the toothpaste composition is used to remove foreign substances in the oral cavity by brushing the teeth by removing the bad breath, or using a fluorine compound such as sodium fluoride, sodium monofluorophosphate, oral antibacterial agents such as triclosan or chlorohexadine hydrochloride to cause bad breath. It has been used to prevent or suppress bad breath. However, the method of removing foreign substances in the oral cavity by brushing using a general toothpaste composition can prevent and suppress bad breath in the short term, but it cannot sustain long-term effects, and trichloroic acid and chlorohexadine hydrochloride, sodium fluoride and monofluorophosphate. Sodium is a chemically synthesized product and cannot be said to be environmentally friendly. In addition, when excessive use of fluorine compounds such as sodium fluoride and sodium fluoride phosphate has side effects such as normal values, the KFDA regulates the amount of fluorine that can be contained in the toothpaste composition to 1000 ppm or less.

In addition, bad breath removal components applied to the oral cavity can be introduced into the living body or flow into the gastrointestinal tract through the oral mucosa, it is particularly necessary to use a material harmless to the human body.

The present invention is devised to solve the above conventional problems, by using an extract extracted from one or two or more of the mugwort of the yuja and many species of wormwood, an excellent inhibitory effect on methylmercaptan which is the main cause of disgusting odor during bad breath Since it is a natural ingredient has no side effects to the human body and to provide an environmentally friendly functional toothpaste composition.

The present invention for achieving the above object is clear bamboo mugwort (open firewood, soybean), sea wormwood, evergreen mugwort (heat keeper, Injin), mountain mugwort, santonin mugwort (Marie maize), Sina mugwort (Siemensina), silk mugwort, mugwort, For removing bad breath containing mugwort extract and citron extract from one or more of mugwort, mugwort The object is achieved by providing a functional toothpaste composition.

In addition, the functional toothpaste composition for removing bad breath, the citron extract is 0.005 to 5.0% by weight, the mugwort extract is preferably 0.01 to 2.0% by weight.

In addition, the functional toothpaste composition for removing bad breath, the citron extract is 0.01 to 1.5% by weight, the mugwort extract is preferably 0.05 to 0.5% by weight.

In addition, the functional toothpaste composition for removing bad breath, the abrasive comprising alternatively or together using 2 to 20% by weight of hydrous silicon dioxide and 2 to 40% by weight of precipitated calcium carbonate; It is preferably configured to include; 10 to 70% by weight of a humectant mixed with one or two or more of D-sorbitol liquid, concentrated glycerin, propylene glycol or Fiji-75.

In addition, the functional toothpaste composition for removing bad breath, the abrasive comprising alternatively or together using 2 to 20% by weight of hydrous silicon dioxide and 2 to 40% by weight of precipitated calcium carbonate; It is preferably configured to include; 10 to 70% by weight of a humectant mixed with one or two or more of D-sorbitol liquid, concentrated glycerin, propylene glycol or Fiji-75.

The effects of the present invention are as follows.

By using the extract extracted from one or two or more of the wormwood and various kinds of mugwort, it has an excellent inhibitory effect on methylmercaptan, which is the main cause of disgusting odor during bad breath, and it is a natural ingredient. It is a very useful invention that can be provided.

The present invention provides a functional toothpaste composition that can effectively suppress the representative methylmercaptan among environmentally friendly and odor-causing substances using natural extracts extracted from citron and wormwood.

Citron extract and mugwort extract from citron fruit and mugwort can be obtained by steam distillation or by using polar and nonpolar organic solvents such as alcohol and butylene glycol, and the yield is usually about 70%.

Yuzu is a plant of the herbaceous herb and used for the treatment of GUNDA GUNDAM as a substitute for tanza in Chinese medicine and in private. Vitamin C contains three times more vitamin C than lemon, which is good for colds and skin care, and contains many organic acids that prevent aging and fatigue. In addition, vitamin B and glycoproteins are more than other citrus fruits, and hesperidin protects capillaries, which prevents cerebrovascular disorders and wind. In addition, drainage (排膿) and excretion effect is to send out the waste accumulated in the body.

Mugwort has about 200 species in the northern hemisphere and 38 species in Korea. It is a perennial herb of the dicotyledon plant Lantern Asteraceae, a plant belonging to the Asteraceae.

The types of mugwort are clear bamboo, mugwort, sand mugwort, heat mugwort, heat mugwort, san mugwort, santonin mugwort (mariti mugwort), syna mugwort (siemensina), silk mugwort, mugwort, mugwort, mugwort (Dungwormwood, Chogo, Hyanggo), Greater evergreen wormwood (Earth evergreen wormwood, Greater evergreen wormwood), there is a mugwort mugwort, yellow wormwood, white wormwood, etc., in the present invention is used wormwood extract from one or two or more of the wormwood.

The main components of mugwort include essence (59%), essential oils, and minerals such as iron, calcium, phosphorus, niacin, and fiber, and vitamin A, vitamin B1, vitamin B2, vitamin C and a large amount of Has chlorophyll

The effects of mugwort are deodorizing effect (eliminates bad smell), gastrointestinal strengthening effect, blood circulation effect, immune function enhancement, detoxification effect, abdominal pain, earth and sand, it is used as a hemostatic agent, insomnia effect, body waste removal effect.

As described above, the citron and mugwort exhibit various effects on the human body when drinking. As a result of manufacturing the toothpaste composition containing the extract thereof, the present inventors can effectively suppress and remove the malodor-causing substances in the oral cavity. It confirmed through the experimental example and the Example.

(Extraction example 1)

1.0 kg of citron fruit shell was washed cleanly, 5.0 kg of purified water and 5.0 kg of butylene glycol were added thereto, and extracted at 50 ° C. for 24 hours, followed by filtration to obtain about 9.0 kg of extract.

Extraction Example 2

Except for using wormwood instead of citron fruit peel it is carried out in the same manner as in Extraction Example 1.

Experimental Example 1 Evaluation of Bad Breath Inhibitory Effect of Citron Extract and Mugwort Extract

In order to measure the inhibitory effect of the citron and mugwort extracts obtained by the above-mentioned method on methylmercaptan, which is the main ingredient of bad breath, the degree of bad breath inhibition was measured using a Halimeter. Dilute methylmercaptan standard solution (1 μg / μl in benzene) in 0.2 M potassium phosphate buffer (pH 7.5) until the Halimeter reading is 500-600 ppb Used as. Citron extract and mugwort extract were dissolved in 0.2M potassium phosphate buffer solution (pH 7.5) to make 1% solution. As a control, 500 μl of buffer solution and 500 μl of bad breath source solution were added to a test tube with a lid, and 500 μl of extract solution and 500 μl of bad breath source solution were added to the experimental group, respectively. Each test tube was allowed to stand in a 36.5 ° C. water bath for 5 minutes, and the amount of sulfur compound in the head-space of the test tube was measured using a Halimeter. The experiments of the control group and the experimental group were repeated four times, respectively, and averaged for each halitometer measurement. The degree of inhibition of bad breath components for 1% solution of each active ingredient is shown in Table 1 below.

Table 1. Inhibition degree of bad breath of experimental bacteria compared to control group (%)

collection Control Citron Extract Mugwort extract One 331 122 139 2 329 122 139 3 330 121 139 4 330 122 139 Sum 1,320 487 556 Average 330.00 121.75 139.00

Referring to Table 1, it can be seen that citron extract and mugwort extract have very strong bad breath inhibitory effects, corresponding to 63.10% and 57.88%, respectively, for methylmercaptan, the main component of bad breath, when compared to the control group.

Hereinafter, the present invention will be described in more detail, but the present invention is not limited thereto.

Hereinafter, the present invention will be described in detail through preferred embodiments. However, the present embodiments should be understood to explain the present invention in a better understanding, and should not be construed as limiting the present invention thereto.

(Examples 1 to 6 and Comparative Example 1)

Toothpaste compositions were prepared using the ingredients and contents shown in Table 2 below.

Table 2.

In general, abrasives of toothpaste include silicon dioxide, hydrous silicon dioxide, dental type silica, colloidal silicon dioxide, precipitated calcium carbonate, calcium hydrogen phosphate, and the like.

In the present invention, 2 to 20% by weight of hydrous silicon dioxide and 2 to 40% by weight of precipitated calcium carbonate are used selectively or together. The water-containing silicon dioxide and precipitated calcium carbonate have less polishing effect than less than 2% by weight, and the removal effect of plaque is less, 20% or more by weight of hydrous silicon dioxide and 40% or more by weight of precipitated calcium carbonate can damage the teeth and gums. Can be.

As a humectant, D-sorbitol liquid, glycerin, concentrated glycerin, propylene glycol, butylene glycol, Fiji-4, Fiji-6, Fiji-8, Fiji-20, Fiji-75, Fiji-150, etc. There is this.

In the present invention, 10 to 70% by weight of the dentifrice composition is preferably mixed with one or two or more of D-sorbitol solution, concentrated glycerin, propylene glycol, and Fiji-75.

Examples of gum disease and periodontal disease prevention include sodium chloride, tocopherol acetate, pyridoxine hydrochloride, aminocaproic acid, allantoin, allantoin chlorohydroxyaluminum, and the like. Sodium pyrophosphate is used for prevention of tartar deposition, sodium lauryl sulfate as foaming agent, methyl paraoxybenzoate, preservative propyl paraoxybenzoate, sodium benzoate, and sweeteners such as saccharin sodium, stevioside, xylitol, Licorice extract is used. As the binder, carboxymethyl cellulose sodium, carrageenan, xanthan gum, guar gum and the like are used.

In order to verify the inhibitory effect on the smell of garlic with the compositions of Examples 1 to 6 and Comparative Example 1, the following experiment was carried out.

(Comparative experiment on garlic odor inhibiting effect)

In this experiment, 20 men and women who did not have dental caries were selected and subjected to a cross-over test.

Commercial garlic powder was dispersed in water, left to stand for 24 hours, and then diluted to obtain 350-450 ppb of the Halimeter. The diluted solution was used as a source of bad breath caused by food. 500 mg of the product of Examples 1 to 6 and 500 μl of the garlic powder diluent were mixed in the experimental group, and the product of the Comparative Example 1 and the garlic powder diluent were mixed in the same manner as the control group. The mixed solution was placed in the mouth and applied with the tongue for 60 seconds in the oral cavity, and then measured by a halimeter. For 1 minute before the measurement, the mouth was shut and breathed only through the nose. During the measurement, the straw was kept in the mouth for about 15 cm for about 15 seconds. At this time, the straw did not touch the tongue, the lips were kept about 3-4mm wide, and the breathing was only nose.

Table 3. (Unit: garlic smell level (ppb))

division 1 minute after brushing Comparative Example 1 329.15 Example 1 320.00 Example 2 213.60 Example 3 173.50 Example 4 130.65 Example 5 117.65 Example 6 112.30

Referring to Table 3, after using the product of Example and the product of Comparative Example by the above method, the result of measuring by Halimeter shows that Comparative Example 1 shows similar value to Example 1, but shows a big difference from other Examples. It was. Example 6 shows a similar value to Example 5. Therefore, to make the composition by adding more than the content of citron extract and mugwort extract added in Example 6 can not expect a distinct effect as increasing content.

(Evaluation of the feeling of toothpaste composition)

In this experiment, a cross-over test was performed on 20 products of male and female who did not have dental caries in order to determine the feeling of use of the toothpaste composition according to the present invention. Based on blinding, taste, taste, and overall feeling of use were evaluated on a 100-point scale. Evaluation performed relative evaluation which made Comparative Example 1 the 0 point. The evaluation results are shown in Table 4 below.

Table 4. Evaluation of feeling of improvement based on Comparative Example 1 (%)

division Taste (%) Taste (%) Overall experience (%) Comparative Example 1 0 0 0 Example 1 12.00 11.25 13.25 Example 2 72.25 74.75 73.50 Example 3 82.00 84.50 83.00 Example 4 70.00 68.25 68.50 Example 5 16.00 17.75 17.00 Example 6 10.75 10.50 11.00

Referring to Table 4, Example 1 and Example 6 was not significantly different from Comparative Example 1, it was shown that Examples 2, 3, 4 as a good taste, taste and overall feeling of use.

The present invention is not limited to the above-described specific preferred embodiments, and various modifications can be made by any person having ordinary skill in the art without departing from the gist of the present invention claimed in the claims. Of course, such changes will fall within the scope of the claims.

The effects of the present invention that can be expected by the configuration and action as described above are as follows.

By using the extract extracted from one or two or more of the wormwood and various kinds of mugwort, it has an excellent inhibitory effect on methylmercaptan, which is the main cause of disgusting odor during bad breath, and it is a natural ingredient. It is a very useful invention that can be provided.

Claims (5)

Clear mugwort (Ginseng mugwort, Gumyeom), sea mugwort, cedar mugwort (heat keeper, Injin), wild mugwort, santonin mugwort (mariti mugwort), Sina mugwort (Siemensina), silk mugwort, mugwort, mugwort, leaflet mugwort , Hyanggo), large flower wormwood (Earth wormwood, large wormwood), ulsan mugwort, yellow wormwood or mugwort mugwort extract functional toothpaste composition characterized in that it contains wormwood extract and citron extract extracted from one or two or more species. The method of claim 1, The citron extract is 0.005 to 5.0% by weight, the wormwood extract is functional toothpaste composition for removing bad breath, characterized in that 0.01 to 2.0% by weight. The method of claim 2, The citron extract is 0.01 to 1.5% by weight, the wormwood extract is functional toothpaste composition for removing bad breath, characterized in that 0.05 to 0.5% by weight. The method of claim 2, Functional toothpaste composition for removing bad breath, An abrasive using alternatively or together 2 to 20% by weight of hydrous silicon dioxide and 2 to 40% by weight of precipitated calcium carbonate; Functional dentifrice composition for removing bad breath, characterized in that it comprises a; D-sorbitol solution, concentrated glycerin, propylene glycol or 10-70% by weight of wetting agent mixed with two or more of 75. The method of claim 3, wherein Functional toothpaste composition for removing bad breath, An abrasive using alternatively or together 2 to 20% by weight of hydrous silicon dioxide and 2 to 40% by weight of precipitated calcium carbonate; Functional dentifrice composition for removing bad breath, characterized in that it comprises a; D-sorbitol solution, concentrated glycerin, propylene glycol or 10-70% by weight of wetting agent mixed with two or more of 75.