JPH10152426A - Sanitary agent for oral cavity containing chinese medicine - Google Patents

Abstract

PROBLEM TO BE SOLVED: To prepare a sanitary agent for an oral cavity capable of manifesting excellent effects unrecognized in each crude drug along such as an improvement in the amount of salivary secretion or salivary buffer ability by including Magnolia officinalis Rehd. Et Wils. in combination with Zedoariae and Artemisia capillaris Thunb. therein. SOLUTION: This sanitary agent for an oral cavity is prepared by formulating (A) Magnolia officinalis Rehd. Et Wils (crude drug name: Magnolia Cortex) with (B) Zedoariae (crude drug name: Zedoariae Rhizoma) and (C) Artemisia capillaris Thunb. at 1:(0.5-1.5):(0.06-0.1) weight ratio and, as necessary, adding (D) Stellaria media Vill. at 1:(0.15-0.3) weight ratio based on the ingredient A, Cinnamomum loureirii Nees at 1:(0.01-0.02) weight ratio based on the ingredient A and a salt at 1:(0.6-0.7) weight ratio based on the ingredient A thereto. The agent is directly utilized or mixed with a suitable carrier or an excipient and utilized as a dentifrice, a gargling, a mouthwash, a denture cleaning agent, a pharmaceutical composition, etc.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to an oral hygiene agent containing a Chinese medicine as an active ingredient, more specifically, a dentifrice, a mouthwash, an anti-inflammatory agent in the oral cavity, an antibacterial agent in the oral cavity, and the like.

2. Description of the Related Art Various bacteriostatic substances are known in which a crude drug is blended in a dentifrice, a mouthwash and the like, and the anti-inflammatory action of the crude drug is utilized. It has also been reported that some crude drugs have bactericidal and bacteriostatic activities against cariogenic bacteria.

[0003] For example, it has been reported that the Japanese cypress (Phoenix) and the Japanese sagebrush (Inchinko) used in the present invention are effective in preventing tooth decay (Showa 56,
Japanese Society of Pharmaceutical Sciences).

Further, it has been reported that gajutsu (jujutsu) used in the present invention is effective for treating periodontal disease (Fukawa dentist, magazine "Wakasa", May 1996).

[0005] However, to the knowledge of the present inventors, there is no example in which a specific herbal component is combined and applied to the oral cavity, for example, as a dentifrice, and findings that disclose or suggest a specific combination of traditional Chinese medicines according to the present invention. Has not been reported.

[0006]

SUMMARY OF THE INVENTION The present inventors have now found that by combining specific crude drug components, it is possible to obtain an oral hygiene agent having an excellent effect which cannot be obtained with each crude drug alone. The present invention is based on this finding.

Accordingly, an object of the present invention is to provide an excellent oral hygiene agent, particularly an oral hygiene agent preferably used in the form of a dentifrice and the like.

[0008] The oral hygiene agent according to the present invention comprises a Japanese sage, a citrus, and a mugwort as active ingredients.

Further, according to the present invention, dentifrices, gargles, mouthwashes, denture cleansers, and pharmaceutical compositions (for example, oral anti-inflammatory agents, oral antibacterials) comprising the above oral hygiene agents. Further, a food additive comprising the oral care agent and a food comprising the same, for example, chewing gum,
Food products such as candies, confectionery, bread, mineral water, drinks, and soft drinks are provided.

Further, according to the present invention, there are provided an oral hygiene agent for animals and an animal feed containing the above oral hygiene agent.

[0011]

DETAILED DESCRIPTION OF THE INVENTION A crude drug component as used herein means a crude drug component generally referred to by the name used herein. That is, its place of origin,
Even if the source is different, it is called by the name used in the present specification, and any crude drug within a range that can be evaluated as equivalent means that it can be used in the present invention. For example, Japanese and Chinese medicine encyclopedia I and II (Tsuneo Namba)
Author, Kikuyosha, 1993 and 1994), Chinese herbal medicine dictionary (Shanghai Science and Technology Publishing, Shogakkan, 1990) and the like.

[0012] The oral hygiene agent according to the present invention basically comprises a Japanese citrus, citrus, and a mugwort as active ingredients. The meaning of these crude drug components is as described above, and the names and specific examples of crude drug components of these crude drug components are as follows.

The name of the Japanese herb is "koboku" (which may be either Japanese or Chinese), and its specific source is Magnoliaceae magnolia.
Magnolia officinalis Rehd. Et Wils. Dried stem bark and root bark.

[0014] In addition, gajutsu is a herbal medicine name is "shajutsu", and as a specific example, the base is Zingibaceae.
eraceae azajutsu Curcuma zedoaria Rosc.

[0015] Furthermore, the name of the mugwort is "Inchinko", a specific example of which is that
mpositae Inchen Artemisia capillaris Thunb. And dried young seedlings.

The amounts of the above three components may be appropriately determined within the range in which the effects of the present invention described below are obtained.
For example, Japanese sage, savory mugwort, and Japanese sagebrush can be added in a weight ratio of about 1: 0.5 to 1.5: 0.06 to 0.1.

Further according to a preferred embodiment of the present invention, the oral hygiene composition according to the present invention preferably further comprises chickweed. Here, the chickweed is, for example, a chickweed Stellaria media of Caryophyllaceae.
(L.) Dried whole grass of Villars. The amount of the chickweed added was 1: 0.15 in terms of weight ratio based on honoki in the mixing ratio of the above three components.
It can be added in an amount of about 0.3.

[0018] According to a preferred embodiment of the present invention, the oral hygiene composition according to the present invention preferably further comprises Nikkei. Here, Nikkei is the name of the crude drug “Ninkei or Cinnamon”, and as a specific example,
It includes dried bark of Laura ceae's Kay Cinamomum cassia Blume and other congeners. The Nikkei is also generally called “cinnamon”, and any name can be used in the present invention. The amount of this Nikkei can be further added in an amount of about 1: 0.01 to 0.02 in terms of a weight ratio based on honoki in the mixing ratio of the above three components.

According to a further preferred embodiment of the present invention, the oral hygiene composition according to the present invention preferably contains a salt. Since salt has a hemostatic effect, it is effective when there is bleeding in the oral cavity or works effectively to prevent bleeding. The amount of the salt to be added may be appropriately determined, and may be added in an amount of about 1: 0.6 to 0.7 by weight based on honoki.

The following effects can be obtained by applying the oral hygiene agent of the present invention to the oral cavity.

First, by applying the oral hygiene agent of the present invention to the oral cavity, the amount of saliva secreted can be increased, and the salivary buffer capacity can be further improved.

Saliva protects the oral cavity, including the teeth,
There are a wide variety of defense mechanisms. Normal secretion of saliva plays an important role both in protecting teeth and in maintaining broad oral health. Therefore,
Increasing this amount of saliva is extremely advantageous in oral hygiene. Furthermore, as for the salivary buffer capacity described later, it is expected that the greater the amount of saliva secreted, the higher its effect will be.

It is considered that dental caries is a phenomenon in which the pH produced in the oral cavity decreases due to the acid produced by the dental caries pathogen in the dental plaque, and the mineral crystals dissolve from the teeth. Therefore, it is expected that the onset and progress of dental caries will be effectively prevented if saliva is less likely to cause a change in pH, that is, has a high buffering capacity. That is, in the present invention, the salivary buffer ability means the ability of saliva to resist fluctuations in pH in the oral cavity. By improving the saliva buffer capacity, the pH in the oral cavity is kept stable, and the pH in the oral cavity does not substantially change even when, for example, a sour food or a rapidly fermentable carbohydrate is ingested. By the way, those who have high salivary buffer capacity are mutansstreptococci
It is known that the caries incidence rate is low even when there are many carious pathogens such as Lactobacillus and cariogenic bacteria.

The above-mentioned improvements in salivary secretion and its buffer capacity are phenomena that are not observed with the herbal medicine alone as an active ingredient of the oral hygiene agent of the present invention. Therefore, it can be said that this effect is a synergistic effect of the herbal medicine combined in the present invention.

According to the oral hygiene agent of the present invention,
Mutans streptococci and Lactobacil in the oral cavity
The breeding of lus can be suppressed. mutans streptoco
cci is said to play a central role in the early development of caries in its strong adhesion and pathogenicity. Furthermore, although Lactobacillus has low fixation to the tooth surface, it is frequently detected from deep inside of carious lesions, such as pits and softened dentin, which have been found. It is believed to play an important role. The oral hygiene agent according to the present invention is thought to play an important role in the occurrence and progression of these caries
It is extremely effective in preventing caries because it suppresses the growth of mutans streptococci and Lactobacillus.

Furthermore, the oral hygiene agent according to the present invention can suppress the propagation of Candida in the oral cavity. Cand
Ida is a fungus, and yeasts make a significant contribution to human diet. However, only a very limited number of fungi are pathogenic to humans. In general, Candida is pathogenic and presents with clinical symptoms when Candida has grown significantly locally and as an opportunistic infection. The majority of oral candidiasis is caused by Candida albicans, with denture stomatitis and thrush being the main ones. It is said that as the age increases, the immune function declines and Candida increases in the oral cavity of the elderly, and Candida has a particularly high ability to adhere to resins,
It is said to adhere stubbornly to dentures. Therefore, the oral hygiene agent according to the present invention is effective for preventing or treating stomatitis, especially denture stomatitis. Furthermore, it can also be used as a denture cleaner.

Further, the oral hygiene agent according to the present invention is effective for preventing or treating periodontal disease. Periodontal disease is an infectious inflammatory disease caused and progressed by certain bacteria in plaque. When the tooth-gingival attachment mechanism is destroyed and a periodontal pocket is formed, plaque on the gingival margin is formed along the tooth surface so as to extend below the gingival margin. Bacteria in the subgingival plaque are thought to damage gingival tissue. According to the oral hygiene agent of the present invention, periodontal disease can be effectively prevented or treated. The mechanism of action is unclear, but Porphyromonas gingivalis, Treponema dent, which is said to be the main pathogen of adult periodontitis
It is thought to be due to suppression of reproduction of icola and Bacteroides forsythus.

Furthermore, the oral hygiene agent according to the present invention significantly suppresses the formation of dental plaque. Caries and periodontal disease are caused by dental plaque bacteria and are believed to progress. It is said that calculus is a substance in which minerals such as calcium and phosphorus are accumulated by bacteria in the plaque, and the plaque is sequentially calcified. Thus, so-called plaque control is said to be a particularly important factor in dental hygiene. The oral hygiene agent according to the present invention not only suppresses the growth of bacteria causing caries and periodontal disease, but also suppresses the formation of plaque, and thus works extremely effectively for maintaining dental hygiene.

Further, the oral hygiene agent according to the present invention improves appearance of periodontal disease symptoms such as swelling, bleeding, drainage, bad breath and tooth sway, improves gingival color, and reduces the depth of periodontal pockets. Decrease,
Clinical effects such as suppression of calculus deposition have been confirmed.

More interestingly, the oral hygiene agent of the present invention is used as a mouthwash after periodontal pocket curettage, gingival resection, flap surgery, etc., to promote wound healing and further reduce postoperative pain. Was observed.

Further, after the toothbrush or mouthwash is performed with the oral hygiene agent according to the present invention, an effect that a refreshing feeling is obtained in the mouth can be obtained. The oral hygiene agent according to the present invention has 300 kinds or more.
It is predicted that it will have a broad spectrum inhibitory effect on over 400 species of oral bacteria.

Further, the oral hygiene agent according to the present invention has an effect of alleviating the symptoms of pharyngitis. In the early stage of pharyngitis such as upper respiratory inflammation and tonsillitis, the use of the oral hygiene agent according to the present invention as a gargle relieves inflammatory symptoms such as redness, swelling and pain.

The oral hygiene agent according to the present invention having the above-mentioned action is used as a dentifrice, gargle, mouthwash, denture cleaner as the above-mentioned active ingredient or as a mixture with a suitable carrier or excipient. , A pharmaceutical composition such as an oral anti-inflammatory agent,
It is used in a form such as an oral antibacterial agent.

For example, in the case of a dentifrice, it may be provided as a powder by mixing the above crude drug components, as a powder, or in the form of a toothpaste containing a known abrasive. The amount of the mixture of the above crude drugs, which is an active ingredient, may be appropriately determined within the range where the above-mentioned effects can be obtained.
It is preferable to add it in an amount of about 0 to 200 mg.

In the case of gargles and mouth washes, they may be provided in the form of a solution in which the above-mentioned active ingredient is dispensed with a Chinese herb together with a suitable flavor, or a dispersant dispersed using a suitable dispersant. The amount of the mixture of the crude drug as an active ingredient may be appropriately determined within the range where the above effects are obtained, but is preferably added so as to be about 500 to 700 mg per gargle or mouthwash. .

[0036] In the case of a denture cleanser, it may be provided as a solution or a dispersant like a mouthwash or a mouthwash, or may be provided as a powder for a toothpaste.
The amount of the mixture of the crude drug as an active ingredient may be appropriately determined within the range where the above effects can be obtained, but is preferably added so as to be about 500 to 700 mg per washing.

Further, in the case of a pharmaceutical composition, the above crude drug component and a pharmaceutically acceptable carrier are mixed, and a suitable dosage form, for example, tablet, granule, powder, pill, fine granule, troche It may be an oral preparation such as a tablet.

The dose may be appropriately determined depending on the individual case in consideration of the symptoms, age, sex, etc. Usually, about 700 to 1000 mg, preferably about 700 to 1000 mg of the active ingredient per adult per day is used. It is preferred to apply it to the oral cavity once or several times a day.

Further, the oral hygiene agent according to the present invention is a food additive which is added to food as a food additive and has a favorable effect on the oral cavity.
In particular, it may be used in the form of a health food. For example, by adding the oral hygiene agent according to the present invention to chewing gum, candy, confectionery, bread, mineral water, drinks, or soft drinks, it is possible to obtain a food that is less likely to cause dental caries.

The oral hygiene agent according to the present invention can be applied not only to humans but also to the oral cavity of animals. Specifically, as an animal dentifrice, an animal mouthwash, an animal drug composition (for example, an oral anti-inflammatory agent or an oral antibacterial agent),
Furthermore, it can be used by mixing it with animal feed. Specifically, these animal oral hygiene agents and animal feeds may be produced according to the description of the specific form of the human oral hygiene agent described above. Since artificially raised animals or pets often require dental hygiene management (for example, caries) compared to wild animals, the oral hygiene agent according to the present invention is extremely useful in animals. It is expected to be something.

[0041]

EXAMPLE Preparation of oral hygiene agent 31 parts by weight of Japanese cypress, 31 parts by weight of gajutsu, 3 parts by weight of Japanese sagebrush, and 7% by weight of chickweed were mixed, and the mixture was 0.1%
It was pulverized into a powder having a size of about mm. Further, 21 parts by weight of a salt was mixed to obtain an oral hygiene agent.

Clinical test Using the above-mentioned oral hygiene agent as a dentifrice, subjects were allowed to perform toothbrushing under the following conditions for a certain period of time. Specifically, three times a day after each meal, about 100 mg of the oral hygiene agent was applied to a toothbrush wetted with water, and the toothbrush was executed. Before and after this test, the effects of the oral care agent of the present invention were evaluated for the following test items.

Test 1 : Evaluation of caries-related factors (1) Measurement of salivary secretion The salivary secretion of a subject was determined as follows. First, the subject was sat upright, given paraffin and chewed. Saliva was swallowed once after 30 seconds, and immediately after that, saliva was exhaled through a funnel into a graduated test tube while chewing for 5 minutes continuously, and the amount of saliva secreted for 5 minutes was measured. Saliva secretion (ml) before and after the practice of brushing according to the invention
/ 5 min) was as shown in the following table. In the effect section in the table, ++ means that an increase of 30% or more was observed, and + means that an increase of less than 30% was observed.

[0044]

[Table 1]

(2) Measurement of Salivary Buffer Capacity The measurement was performed using a Dentobuff Strip (manufactured by Morimura Co., Ltd.) capable of measuring salivary buffer capacity. According to Dentobuff Strip, salivary buffer capacity can be evaluated in four steps. For specific measurement, first, a saliva sample was taken with a pipette, dropped on a strip, and after 5 minutes, the color of the strip and the color chart were compared. In this kit, the buffer capacity of saliva is classified into immediate blue, blue, green, and yellow levels in descending order.

The results were as shown in the following table. In the table, ← indicates the color before the test, ○ indicates the color after the test, and ◎
Indicates that there was no change before and after the test. Further, ++, +, 0, and-in the effect section mean that the color classification has been improved by two levels, one level, zero level, and -1 level, respectively.

[0047]

[Table 2]

(3) Measurement of the number of bacteria of mutans streptococci The number of bacteria of mutans streptococci in the oral cavity was measured using a Dentocult-SM kit (manufactured by Morimura Co., Ltd.). here,
Dentocult-SM is a test medium capable of examining the number of mutans streptococci in saliva. First, the strip rotated on the tongue was put into the culture solution containing the bacitracin tablet in the kit, and cultured at 37 ° C. for 2 days. mutans
The streptococci appeared as blue colonies on the strip, and the number of the bacteria was determined by comparing the density of the colonies on the strip with the model chart.

The results were as described in the following table. In the table, 0, 1, 2, and 3 in the results section indicate saliva 1
The number of bacteria in each ml is about 0, 100,000, 500,000, and 1,000,000, respectively. ← indicates the number of bacteria before the test, は indicates the number of bacteria after the test, and は indicates the number of bacteria after the test. This shows that there was no change before and after. In addition, +
+, +, 0, and-mean that the number of bacteria was improved by 2, 1, 0, and -1 levels, respectively.

[0050]

[Table 3]

(4) Measurement of the number of Lactobacillus bacteria The number of Lactobacillus bacteria in the oral cavity was measured using a Dentocult-LB kit (Morimura Co., Ltd.). here,
Dentocult-LB is a test medium capable of examining the number of Lactobacillus in saliva. First, let the saliva sample flow on both sides of the slide with the medium impregnated in the kit.
The cells were cultured at 7 ° C for 4 days. Lactobacillus appeared as white colonies on the slide, and the number of bacteria was determined by comparing the density of the colonies on the slide with the model chart.

The results were as described in the following table. In the table, 0, 1, 2, and 3 in the results section indicate saliva 1
about 1000, 10,000, 1
Meaning of each level of 100,000 and 1,000,000, ← indicates the number of bacteria before the test, ○ indicates the number of bacteria after the test, and ◎ indicates that there was no change before and after the test. In addition, +
+, +, 0, and-mean that the number of bacteria was improved by 2, 1, 0, and -1 levels, respectively.

[0053]

[Table 4]

Test 2: Measurement of Oral Bacterial Candida The number of Candida in the oral cavity was examined using Oricult-N (Morimura Co., Ltd.). The saliva samples collected on both sides of the slide to which the Nickerson medium was applied were flowed, and 37 ° C.
And cultured for 2 days. Candida appeared as a brown colony on the slide, and the bacterial count was determined by comparing the density of the colony on the slide with the model chart.

The results were as shown in the following table. In the table, 0, 1, 2, and 3 in the results section indicate saliva 1
about 1000, 10,000, 1
Meaning of each level of 100,000 and 1,000,000, ← indicates the number of bacteria before the test, ○ indicates the number of bacteria after the test, and ◎ indicates that there was no change before and after the test. In addition, +
+, +, 0, and-mean that the number of bacteria was improved by 2, 1, 0, and -1 levels, respectively.

[0056]

[Table 5]

Test 3: Evaluation of factors related to periodontal disease Porphyromonas, which is said to be the main pathogen of adult periodontitis
gingivalis, Treponema denticola, and Bacteroide
s forsythus was examined by a periodontal pathogen test (Periocheck, manufactured by Sunstar Co., Ltd.), which specifically detects the enzyme produced by S. forsythus. First, a paper point inserted into the deepest part of the periodontal pocket for 30 seconds was directly charged into the vial containing the substrate and the chromogen, and the enzyme solution was added.
After incubating at 37 ° C. for 15 minutes, the degree of blue change was compared with a standard color tone (color sample) to measure the peptidase activity from these periodontopathogens.

The results were as described in the following table. In the table, (-) in the results section is negative, (+) is positive,
(++) means strong positive, ← means results before the test, ○ means results after the test, and ◎ means no change before and after the test. Further, ++, +, 0, and-in the effect section mean that the level is improved by two levels, one level, zero level, and -1 level, respectively.

[0059]

[Table 6]

Test 4: Measurement of Plaque Adhesion Amount of plaque adhesion of the subject was determined by quick impression, and evaluated by classifying the following four scores.
The basis of plaque removal is brushing,
In order to obtain an objective evaluation, brushing instruction was not performed, and the subject's conventional brushing method was followed. -Score 0: excellent mouth cleaning, no plaque. Score 1: good oral cleansing, plaque at the border of the gingiva, such as a thin film. It looks like it is raked with a dentist's probe. -Score 2: Medium oral cleansing, plaque is visible along the gingival border. Not between teeth. Score 3: unacceptable oral cleansing, numerous plaques along the gingival border. There are many plaques between teeth.

The results were as shown in the following table. The number in the result column means the score. Further, ++, +, 0, and-in the effect section mean that the level is improved by two levels, one level, zero level, and -1 level, respectively.

[0062]

[Table 7]

Test 5: Other In addition, the following clinical effects were observed by clinical observation.

(1) Improvement of external periodontal disease symptoms External periodontal disease symptoms such as swelling, bleeding, drainage, bad breath, and tooth sway were remarkably improved. Swelling associated with periodontal disease,
Symptoms such as bleeding, drainage, bad breath, and tooth sway are as early as a few days, usually about a week to 10 days, and late as 1
It was confirmed that it would be improved in about a month.

(2) Improvement of gingival color The gingival color varies from individual to individual depending on the degree of physiological deposition of melanin pigment and the thickness of the epithelial mucosa. doing. When gums become unhealthy due to periodontal disease, the gums become reddish,
Although it darkens, as a result of this test, it was confirmed that the color was improved to pink in about 1 week at the earliest, usually about 1 month. At the same time, it was confirmed that the gums became firmer.

(3) Decrease in the depth of the periodontal pocket As periodontal disease progresses, the periodontal ligament is destroyed, the gingiva and the root are peeled off, and a periodontal pocket is formed. It was confirmed that even if the depth of the periodontal pocket was 5 mm or more, which was evaluated as serious, it gradually decreased.

(4) Inhibition of calculus deposition In the case of using the oral hygiene agent according to the present invention for a long time,
It was confirmed that there was little calculus deposition.

(5) Improvement of the post-operative course After the periodontal pocket curettage, gingival resection, flap surgery, etc., if the mouth washes with the oral hygiene agent of the present invention, the post-operative course such as gingival adhesion, gingival regeneration, etc. Was confirmed to be favorable. In addition, an effect of relieving postoperative pain was observed.

(6) Improvement of Oral Hygiene Environment After brushing with the dentifrice according to the present invention, many people felt a refreshing feeling in the mouth.

(7) Alleviation of Symptoms of Pharyngitis In the early stage of pharyngitis such as upper respiratory inflammation and tonsillitis, if the oral hygiene agent according to the present invention is used as a mouthwash, redness, swelling,
It was confirmed that inflammatory symptoms such as pain were alleviated.

Claims (12)

[Claims] (1) An oral hygiene composition comprising a Japanese radish, a maggot and a sagebrush as active ingredients. 2. The oral hygiene agent according to claim 1, further comprising chickweed. 3. The oral hygiene agent according to claim 1, which further comprises Nikkei. 4. The oral hygiene agent according to any one of claims 1 to 3, which has a property of being hardly carious and / or having periodontal disease. 5. The oral hygiene agent according to any one of claims 1 to 4, further comprising a salt. 6. The method according to claim 1, which is in the form of a dentifrice, gargle, mouthwash, denture cleanser, pharmaceutical composition, oral anti-inflammatory agent, or oral antibacterial agent. The oral hygiene agent as described. 7. A food additive comprising the oral hygiene agent according to any one of claims 1 to 5. 8. A food comprising the food additive according to claim 7. 9. The food according to claim 8, which is in the form of chewing gum, candy, confectionery, bread, mineral water, a drink, or a soft drink. 10. An oral hygiene agent for animals, comprising the oral hygiene agent according to any one of claims 1 to 5. 11. The oral hygiene agent according to claim 10, which is in the form of an animal dentifrice, a mouthwash, an oral anti-inflammatory agent or an oral antibacterial agent. 12. An animal feed comprising the oral care agent according to any one of claims 1 to 5.